Traditional Chinese medicine formula for treating epilepsy

Abstract

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine formula for treating epilepsy, which is prepared from the following raw materials in parts by weight: 10-15 parts of lapis chloriti, 10-12 parts of bryozoatum, 8-10 parts of massa medicata fermentata fujianensis, 6-9 parts of acorus calamus, 9-12 parts of processed rhizoma pinelliae, 6-9 parts of processed rhizoma arisaematis, 3-6 parts of agilawood, 12-15 parts of radix rehmanniae, 12-15 parts of radix rehmanniae preparata, 3-6 parts of black semen pharbitidis and 3-6 parts of white semen pharbitidis. The preparation method comprises the following steps: step 1, pretreating the medicinal materials: calcining and quenching the lapis chloriti and the bryozoatum, and crushing into fine powder (passing through a 100-mesh sieve); cleaning the processed rhizoma pinelliae, the processed rhizoma arisaematis, the acorus calamus, the agilawood, the radix rehmanniae, the radix rehmanniae preparata and the massa medicata fermentata fujianensis, drying at 60-70 DEG C for 2 hours, and crushing into coarse powder; step 2, extracting and concentrating; step 3, mixing and forming; the traditional Chinese medicine formula for treating epilepsy provided by the invention has the beneficial effects that both symptoms and root causes are treated, the curative effect is remarkable, the preparation process is standardized, and the epileptic seizure symptom and physique basis are improved through accurate compatibility of products for reducing phlegm and inducing resuscitation, extinguishing wind and relieving convulsion, and nourishing yin and blood.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine, and specifically relates to a traditional Chinese medicine formula for treating epilepsy. Background Art

[0002] Epilepsy is a common chronic neurological disease, characterized by abnormal discharge of brain neurons leading to recurrent, paroxysmal and transient central nervous system dysfunction. At present, clinical treatment mainly relies on anti-epileptic drugs, but some patients have problems such as drug tolerance, obvious side effects or poor efficacy. Traditional Chinese medicine has the advantages of overall conditioning and relatively small side effects in the treatment of epilepsy. Traditional prescriptions such as Mengshi Guntan Pills and Wendan Decoction have certain curative effects on epilepsy with phlegm turbidity blocking the orifices, but there is still room for improvement in the targeted compatibility, efficacy optimization and preparation process standardization of existing formulas. Specifically, the following deficiencies exist:

[0003] 1. Traditional prescriptions mainly focus on resolving phlegm and calming wind, lacking comprehensive conditioning of the pathogenesis of "deficiency in origin and excess in superficiality".

[0004] 2. The preparation process is rough, and the dissolution rate of active ingredients is low, affecting the stability of drug efficacy.

[0005] 3. The personalized compatibility plan for different syndromes of epilepsy is not yet systematic. Summary of the Invention

[0006] To overcome the technical defects in the prior art and effectively solve the technical problems in the background art, the present invention provides the following technical solutions:

[0007] A traditional Chinese medicine formula for treating epilepsy, which is composed of the following raw materials in parts by weight: 10 - 15 parts of chlorite schist, 10 - 12 parts of pumice, 8 - 10 parts of Jianqu (medicated leaven), 6 - 9 parts of calamus, 9 - 12 parts of processed pinellia, 6 - 9 parts of processed arisaema, 3 - 6 parts of agarwood, 12 - 15 parts of raw rehmannia root, 12 - 15 parts of prepared rehmannia root, 3 - 6 parts of black morning glory seed, and 3 - 6 parts of white morning glory seed.

[0008] A preparation method of a traditional Chinese medicine formula for treating epilepsy, comprising the following steps:

[0009] Step 1: Pretreatment of medicinal materials;

[0010] Calcine and quench chlorite schist and pumice, and then pulverize them into fine powder (pass through a 100-mesh sieve); after cleaning and drying (at 60 - 70°C for 2 hours) processed pinellia, processed arisaema, calamus, agarwood, raw rehmannia root, prepared rehmannia root, and Jianqu (medicated leaven), pulverize them into coarse powder;

[0011] Step 2: Extraction and concentration;

[0012] Take the coarse powder of medicinal materials, add 8 - 10 times the amount of distilled water, decoct 2 times (1.5 hours each time), combine the decoction liquid, filter, and then concentrate under reduced pressure to a clear paste with a relative density of 1.15 - 1.20 (measured at 60°C);

[0013] Step 3: Mixing and Molding;

[0014] Mix the fine powder of lapis chloriti and pumice with the clear extract in a ratio of 1:1, add an appropriate amount of starch paste as a binder, granulate and then dry (at 50 - 60 °C), screen the granules, and prepare the required dosage form as needed.

[0015] Compared with the prior art, the beneficial effects of the present invention are as follows: 1. Therapeutic effect advantages:

[0016] Multi-target action: It targets both pathological factors such as phlegm, wind, and stasis, and regulates the functions of viscera such as the liver, kidney, and spleen, reducing the frequency and duration of epileptic seizures;

[0017] Clinical verification: Through 1000 cases of clinical observation, the total effective rate reached 85%, which was significantly better than the simple western medicine control group (P < 0.05).

[0018] 2. Process advantages:

[0019] (1) The calcination and quenching process improves the dissolution rate of the active ingredients of mineral drugs;

[0020] (2) Mixing water decoction concentration with solid powder takes into account the rapid effect of decoction and the portability of patent medicine;

[0021] (3) The dosage form can be flexibly adjusted according to the needs of patients, improving medication compliance.

[0022] In the present invention:

[0023] 1. The pharmacological effects of the traditional Chinese medicine formula composition:

[0024] Lapis chloriti: Draining phlegm and lowering qi, calming the liver and extinguishing wind;

[0025] Pumice: Clearing the lung and resolving phlegm, softening hardness and dissipating nodules;

[0026] Jianqu: Promoting digestion and resolving food stagnation, regulating the spleen and stomach;

[0027] Acorus tatarinowii: Opening orifices and resolving phlegm, awakening the mind and improving intelligence;

[0028] Pinellia ternata processed with ginger: Drying dampness and resolving phlegm, lowering adverse qi and stopping vomiting;

[0029] Arisaema heterophyllum processed with ginger: Dispelling wind and stopping convulsions, dissipating nodules and relieving swelling;

[0030] Aquilaria sinensis: Promoting qi circulation to relieve pain, warming the kidney and assisting inspiration;

[0031] Rehmannia glutinosa var. purpurea: Clearing heat and cooling blood, nourishing yin and promoting the production of body fluid;

[0032] Rehmannia glutinosa: Tonifying blood and nourishing yin, replenishing essence and marrow;

[0033] Pharbitis nil: Draining water and promoting defecation, eliminating phlegm and removing fluid retention;

[0034] White Falsenard Seed: It synergizes with Black Falsenard Seed to enhance the power of expelling water and eliminating phlegm.

[0035] 2. Compatibility Principle:

[0036] Treating the symptoms: Chlorite Schist, Pumice, Prepared Pinellia Rhizome, Prepared Jackinthepulpit Tuber together achieve the effects of eliminating stubborn phlegm and calming liver wind, targeting the core pathogenesis of "wind-phlegm blockage" during the seizure period of epilepsy; Acorus Calamus opens the orifices and awakens the mind, and Aquilaria Sinensis regulates qi and reduces adverse qi, promoting the smooth flow of qi to assist in resolving phlegm.

[0037] Treating the root cause: Rehmannia Root (Raw) and Rehmannia Root (Prepared) nourish yin and blood, filling the deficiency of liver and kidney yin; Medicated Leaven regulates the spleen and stomach, preventing excessive attack from damaging the acquired foundation; White Falsenard Seed and Black Falsenard Seed promote urination and defecation, enabling phlegm turbidity to be excreted through urine and feces, meaning that "the pathogen has a way out".

[0038] 3. Characteristics of the whole formula: It combines attacking and tonifying, resolving phlegm without damaging healthy qi, nourishing yin without hindering the pathogen, and is applicable to epilepsy patients with internal accumulation of phlegm turbidity and deficiency of liver and kidney yin, showing symptoms such as gurgling phlegm in the throat and unconsciousness during seizures, and dizziness, tinnitus, soreness and weakness of the waist and knees in normal times. Brief Description of the Drawings

[0039] Figure 1 It is the value of the average seizure times of mice in the present invention. Detailed Embodiments

[0040] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

[0041] Example 1: Preparation of Tablets

[0042] Raw materials:

[0043] Chlorite Schist 12g, Pumice 10g, Medicated Leaven 8g, Acorus Calamus 6g, Prepared Pinellia Rhizome 9g, Prepared Jackinthepulpit Tuber 6g, Aquilaria Sinensis 3g, Rehmannia Root (Raw) 12g, Rehmannia Root (Prepared) 12g, Black Falsenard Seed 3g, White Falsenard Seed 3g.

[0044] Preparation:

[0045] Chlorite Schist and Pumice are calcined and quenched and then pulverized into fine powder; the remaining medicinal materials are decocted to obtain clear extract;

[0046] The fine powder and the clear extract are mixed, 20g of starch is added to make granules, and tablets are pressed after drying.

[0047] Example 2: Preparation of Capsules

[0048] Raw materials:

[0049] Lapis Chloriti 15g, Pumex 12g, Massa Fermentata Medicinalis 10g, Acorus tatarinowii 9g, Pinellia ternata preparata 12g, Arisaema heterophyllum preparata 9g, Aquilariae Lignum Resinatum 6g, Radix Rehmanniae 15g, Radix Rehmanniae Preparata 15g, Pharbitis niger 6g, Pharbitis alba 6g.

[0050] Preparation:

[0051] Pretreat the medicinal materials in the same way as in Example 1;

[0052] Dry the mixed materials and pulverize them into fine powder, then fill into capsules.

[0053] Experimental Example 1

[0054] Select 30 healthy adult mice of SPF - level BALB / c with uniform body weight, similar age and body fat percentage, and randomly divide them into 3 groups, with 10 mice in each group, namely Example 1 group, Example 2 group and Example 3 group. After inducing epileptic seizures in each group of mice (such as intraperitoneal injection of pentylenetetrazol, electrical stimulation, etc.), intragastric administration is given at a dose equivalent to 10g of crude drug per kilogram of body weight, and the administration is continued for 4 - 8 weeks; record the average number of epileptic seizures in each group of mice after administration (such as the average number of seizures within 24 hours), and compare with the control group to judge whether the drug can reduce the seizure frequency.

[0055] Result analysis: As Figure 1 shown, the number of epileptic seizures in the mice of Example 1 - 3 groups has decreased significantly. Among them, the number of epileptic seizures in the mice of Example 1 group is the least, followed by Example 2 group and Example 3 group.

[0056] Although the embodiments of the present invention have been shown and described, for those of ordinary skill in the art, it can be understood that various changes, modifications, substitutions and variations can be made to these embodiments without departing from the principles and spirit of the present invention. The scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A Chinese medicine formula for treating epilepsy, characterized in that: The invention is composed of the following raw materials in parts by weight: 10-15 parts of bluestone, 10-12 parts of pumice, 8-10 parts of Jianqu, 6-9 parts of calamus, 9-12 parts of processed pinellia, 6-9 parts of processed arisaema, 3-6 parts of agarwood, 12-15 parts of raw rehmannia, 12-15 parts of cooked rehmannia, 3-6 parts of black atractylodes and 3-6 parts of white atractylodes.

2. The method for preparing the Chinese medicine formula for treating epilepsy according to claim 1, characterized in that: The steps include: Step 1: Pretreatment of medicinal materials; Calcining and quenching the bluestone and pumice, and then crushing them into fine powder (passing through a 100-mesh sieve); drying the processed pinellia, processed arisaema, calamus, agarwood, raw rehmannia, cooked rehmannia, and jianqu (60-70°C, 2 hours), and then crushing them into coarse powder; Step 2: Extraction and concentration; Take the coarse powdered medicinal material, add 8-10 times the amount of distilled water, decoct twice (1.5 hours each time), combine the decoctions, filter and concentrate under reduced pressure to a clear paste with a relative density of 1.15-1.20 (measured at 60℃); Step 3: Mixing and molding; Mix bluestone, pumice powder and clear paste in a ratio of 1:1, add appropriate amount of starch paste as a binder, granulate and dry (50-60℃), granulate and make the required dosage form as needed.

3. The method for preparing the Chinese medicine formula for treating epilepsy according to claim 2, characterized in that: The dosage form prepared in step 3 is a tablet.

4. The method for preparing the Chinese medicine formula for treating epilepsy according to claim 2, characterized in that: The dosage form prepared in step 3 is a capsule.

5. The method for preparing the Chinese medicine formula for treating epilepsy according to claim 2, characterized in that: The dosage form prepared in step 3 is a granule.

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