Traditional Chinese medicine hot compress formula for treating qi stagnation and blood stasis type lumbar intervertebral disc protrusion

Abstract

The invention discloses a traditional Chinese medicine hot compress formula for treating qi stagnation and blood stasis type lumbar intervertebral disc protrusion, and belongs to the technical field of traditional Chinese medicine compounds. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicines: deer sinew, cissus pteroclada hayata, bauhinia championii, kadsura coccinea, cassia twig, radix clematidis The traditional Chinese medicines are ground into coarse powder, mixed with a proper amount of halite and bagged to obtain the hot pack. According to the traditional Chinese medicine hot compress formula, deer sinew is used as a monarch drug for tonifying kidney yang, strengthening muscles and bones, nourishing blood and dredging collaterals, and generating essence and benefiting marrow; cissus pteroclada hayata, bauhinia championii and kadsura coccinea are used as ministerial drugs to dispel wind, eliminate dampness, activate Radix aconiti preparata, radix aconiti kusnezoffii preparata, cassia twig and dragon's blood have the effects of warming the interior, dispelling cold, promoting blood circulation, dredging collaterals and relieving pain and are Radix clematidis, radix cyathulae, notopterygium root and lycopodium clavatum are used as adjuvant drugs to dredge collaterals, joints and expel wind Divaricate Saposhnikovia Root is an adjuvant drug to prevent exogenous evil from entering Camphor and borneol are used as conductant drugs to introduce the drugs into the body; halite conducts heat and transfers heat. The traditional Chinese medicine composition has the effects of promoting blood circulation to remove blood stasis and promoting qi circulation to relieve pain through a large number of pungent-divergent and warm-dredging medicines, and has a good treatment effect on qi stagnation and blood stasis type lumbar intervertebral disc protrusion.

Description

Technical Field

[0001] The present invention belongs to the technical field of traditional Chinese medicine compound, and specifically relates to a traditional Chinese medicine hot compress formula for treating lumbar disc herniation of qi stagnation and blood stasis type. Background Art

[0002] Qi stagnation and blood stasis syndrome refers to the pathological state in which qi stagnation and blood stasis exist simultaneously. Generally, it is often caused by the unsmooth flow of qi in the human body first, and then the stasis of blood circulation. The main clinical manifestations are local distension or pain symptoms. Prolonged qi stagnation can cause blood stasis, forming qi stagnation and blood stasis, which intensifies the local pain. Due to the different causes of diseases, the same symptom can also be caused by different reasons. The diseases caused by qi stagnation and blood stasis are called qi stagnation and blood stasis type diseases.

[0003] Lumbar disc herniation of qi stagnation and blood stasis type is mainly manifested as stabbing pain in the waist, pain with a fixed location, refusal to press, and severe pain at night, etc. The treatment should be based on promoting blood circulation to remove blood stasis and dredging collaterals to relieve pain for syndrome differentiation and treatment. Chinese Patent Application CN 110638951A discloses a compound cataplasm for treating lumbar disc herniation of qi stagnation and blood stasis type and its preparation method. The compound cataplasm contains the following raw materials in parts by weight: 5 - 15 parts of cyperus rotundus, 10 - 20 parts of herba speranskiae tuberculatae, 5 - 15 parts of safflower, 5 - 15 parts of cyathula officinalis, 5 - 15 parts of rhizoma imperatae, 5 - 15 parts of lycopodium clavatum, 5 - 15 parts of angelica sinensis, 5 - 15 parts of sargentodoxa cuneata, 5 - 15 parts of cortex acanthopanacis gracilis, 5 - 15 parts of ground beetle, 5 - 15 parts of rhizoma corydalis, 5 - 15 parts of dipsacus asperoides, 5 - 15 parts of peach kernel, 5 - 15 parts of chuanxiong rhizome, 5 - 15 parts of sappanwood, 5 - 15 parts of dragon's blood, 5 - 15 parts of stone crab, 5 - 15 parts of angelica pubescens, 5 - 15 parts of frankincense and 5 - 15 parts of myrrh. The specification points out that this traditional Chinese medicine compound cataplasm has the effects of promoting blood circulation to remove blood stasis, anti - inflammation and pain relief, etc., and has remarkable curative effect on lumbar disc herniation of qi stagnation and blood stasis type. The compound cataplasm is convenient to use, safe, comfortable, painless, and the viscosity of the cataplasm is sufficient, and the plaster will not stain clothes. Chinese Patent Application CN 108578454A discloses a preparation method of a traditional Chinese medicine composition, traditional Chinese medicine preparation and decoction for treating lumbar disc herniation of wind - cold obstruction and qi stagnation and blood stasis type. The traditional Chinese medicine composition contains the following raw materials in parts: 5 - 50 parts of angelica pubescens, 5 - 50 parts of chuanxiong rhizome, 3 - 50 parts of bombyx batryticatus, 3 - 50 parts of pheretima aspergillum and 3 - 50 parts of ground beetle. The specification points out that this formula uses angelica pubescens as the monarch drug, chuanxiong rhizome as the minister drug, and bombyx batryticatus, pheretima aspergillum and ground beetle as the adjuvant drugs. By comprehensively utilizing the action advantages and mutual synergistic effects of the above traditional Chinese medicine raw materials, it has the effects of expelling wind and dampness, dispelling cold and relieving pain, removing dampness and relieving arthralgia, and promoting blood circulation to remove blood stasis, etc., and has remarkable curative effect on lumbar disc herniation of wind - cold obstruction and qi stagnation and blood stasis type.

[0004] According to traditional Chinese medicine syndrome differentiation and treatment, for diseases of qi stagnation and blood stasis type, selecting appropriate traditional Chinese medicines requires achieving the effects of promoting blood circulation to remove blood stasis and promoting qi flow to relieve pain. Traditional Chinese medicine hot compress therapy has the effects of dilating blood vessels, improving local blood circulation, and promoting local metabolism, which is beneficial to the recovery of diseases. Traditional Chinese medicine hot compress itself can also relieve muscle spasms, promote the absorption of inflammation and blood stasis. Traditional Chinese medicine hot compress can also enable the medicine to be absorbed locally, achieving the purpose of directly reaching the affected area, making the treatment more direct and effective.

[0005] In view of this, the present invention proposes a traditional Chinese medicine hot compress formula with the effects of promoting blood circulation to remove blood stasis and promoting qi flow to relieve pain, which can effectively treat lumbar disc herniation of qi stagnation and blood stasis type and has good treatment effects. Summary of the Invention

[0006] The technical problem to be solved by the present invention is to provide a traditional Chinese medicine hot compress formula for treating lumbar disc herniation of qi stagnation and blood stasis type. The combined use of various medicines can jointly achieve the effects of promoting blood circulation to remove blood stasis and promoting qi flow to relieve pain. Combining with traditional Chinese medicine hot compress can have good curative effects on lumbar disc herniation of qi stagnation and blood stasis type.

[0007] In order to achieve the above purpose, the technical solution adopted by the present invention is as follows:

[0008] A traditional Chinese medicine hot compress formula for treating lumbar disc herniation of qi stagnation and blood stasis type is composed of the following traditional Chinese medicine raw materials by weight:

[0009] Deer tendon 15 - 50g, Tetrastigma siamense 10 - 25g, Bauhinia championii 15 - 25g, Kadsura coccinea 10 - 25g, Cinnamon twig 10 - 20g, Clematis chinensis 12 - 16g, Saposhnikovia divaricata 12 - 18g, Radix Aconiti preparata 14 - 16g, Radix Aconiti Kusnezoffii preparata 14 - 16g, Cyathula officinalis 5 - 20g, Notopterygium incisum 10 - 20g, Lycopodium clavatum 10 - 20g, Dragon's blood 12 - 17g, Safflower 5 - 12g, Camphor 1 - 3g, Borneol 1 - 5g;

[0010] Grind each traditional Chinese medicine into coarse powder, and mix it with an appropriate amount of big green salt and pack it into a bag to obtain a hot compress package.

[0011] In this compound formula:

[0012] Deer tendon strengthens tendons and bones, nourishes blood and dredges collaterals, generates essence and marrow, and is mainly used for treating overstrain, continuous injury, strengthening tendons and bones greatly, and tonifying yang qi.

[0013] Tetrastigma siamense dispels wind and dampness, promotes blood circulation and dredges collaterals. It is mainly used for treating rheumatic arthralgia, lumbar muscle strain, limb paralysis, and traumatic injury.

[0014] Bauhinia championii dispels wind and dampness, promotes blood circulation and relieves pain. It has the effects and functions of clearing heat and detoxifying, relieving swelling and pain, promoting blood circulation to remove blood stasis, promoting diuresis and subsiding jaundice, and regulating immunity.

[0015] Kadsura coccinea promotes qi flow to relieve pain, disperses stasis and dredges collaterals. It has the effects of promoting qi flow to relieve pain and dispersing stasis and dredging collaterals.

[0016] Ramulus Cinnamomi induces sweating to relieve the exterior syndrome, warms and dredges the meridians, promotes yang qi transformation, and calms the surging qi. It is used for wind-cold common cold, cold pain in the epigastrium and abdomen, amenorrhea due to blood cold, arthralgia, phlegm retention, edema, palpitation, and rushing of qi.

[0017] Clematis Root dispels wind-dampness and dredges the meridians. It is used for wind-damp arthralgia, numbness of limbs, contraction of tendons and vessels, and difficulty in flexion and extension.

[0018] Ledebouriella Root has the functions of expelling wind and relieving the exterior syndrome, eliminating dampness and relieving pain, and stopping convulsions.

[0019] Prepared Aconitum Carmichaelii and Prepared Aconitum Kusnezoffii have the effects of promoting blood circulation to remove stasis, warming the meridians and dredging collaterals, and dispelling wind and cold. Although aconitine is highly toxic, in this formula, Prepared Aconitum Carmichaelii and Prepared Aconitum Kusnezoffii are administered by external hot compress, which has no irritation to intact skin. After multiple administrations, it has slight irritation to damaged skin, but the irritation disappears after medication, and there is no safety hazard.

[0020] Cyathula Root nourishes the liver and kidney, strengthens the tendons and bones, promotes blood circulation to remove stasis, induces diuresis and alleviates stranguria, and guides blood downward.

[0021] Notopterygium Root dispels wind and dampness, soothes the tendons and activates collaterals, relieves headache, has anti-inflammatory and analgesic effects, and improves the circulatory system

[0022] Lycopodium Herb dispels wind and cold, soothes the tendons and activates blood circulation, removes dampness and reduces swelling, has anti-inflammatory effects, and relieves cough and detoxifies.

[0023] Dragon's Blood promotes blood circulation to stop pain, dispels stasis and stops bleeding, and promotes granulation and heals sores. It is used for traumatic injury, heart and abdominal pain, external bleeding, and non-healing ulcers.

[0024] Safflower promotes blood circulation and dredges the meridians, dispels stasis and relieves pain. It is used for amenorrhea, dysmenorrhea, retention of lochia, abdominal mass, chest impediment pain, stasis abdominal pain, chest and hypochondrium stabbing pain, traumatic injury, and swelling and pain of sores and ulcers.

[0025] Camphor has the effects of expelling wind and cold, promoting blood circulation and relieving pain, relieving itching, and preventing and expelling insects

[0026] Borneol has the effects of relieving pain and preventing putrefaction, antibacterial and anti-inflammatory, clearing heat and relieving pain, removing nebula and improving eyesight, and soothing the skin.

[0027] The traditional Chinese medicine hot compress formula (Wenyang Qingyan Hot Compress Pack) for treating lumbar intervertebral disc herniation of qi stagnation and blood stasis type proposed by the present invention highly values deer tendon, which is used as the monarch drug for tonifying kidney yang, strengthening tendons and bones, nourishing blood and dredging collaterals, and generating essence and marrow. Tetrastigma siamense, Bauhinia championii, and Kadsura coccinea are used as ministerial drugs to dispel wind and dampness, promote blood circulation, and activate qi and dredge collaterals. Prepared Aconitum Carmichaelii, Prepared Aconitum Kusnezoffii, Ramulus Cinnamomi, Dragon's Blood, and Safflower warm the interior and expel cold, promote blood circulation and dredge collaterals to relieve pain, and are used as ministerial drugs together; Clematis Root, Cyathula Root, Notopterygium Root, and Lycopodium Herb are used as adjuvant drugs to dredge joints and dispel wind-dampness. Ledebouriella Root is used as an adjuvant drug to prevent exogenous pathogens from entering the interior. Camphor and Borneol are used as guiding drugs to introduce all the drugs into the body; Big Blue Salt conducts heat and transfers heat. The whole formula uses a large number of pungent-dispersing and warm-dredging drugs to achieve the effects of promoting blood circulation to remove stasis and promoting qi movement to relieve pain.

[0028] As a preferred technical solution of the present invention, the traditional Chinese medicine hot compress formula for treating lumbar disc herniation of qi stagnation and blood stasis type is composed of traditional Chinese medicine raw materials with the following weights:

[0029] 30g of deer tendon, 20g of tetragonal rattan, 20g of nine-dragon rattan, 20g of kadsura coccinea, 15g of cinnamon twig, 15g of clematis root, 15g of ledebouriella root, 15g of prepared common monkshood mother root, 15g of prepared kusnezoff monkshood root, 15g of cyathula root, 15g of incised notopterygium root, 15g of lycopodium clavatum, 15g of dragon's blood, 10g of safflower, 2g of camphor, 2g of borneol;

[0030] The various traditional Chinese medicines are ground into coarse powder and mixed with 1000g of large green salt and packed into bags to obtain a hot compress package.

[0031] Before use, the hot compress package is heated in a microwave oven on medium heat and then applied to the affected area until the medicine package cools down. It is applied once in the morning and once in the evening every day, and each package can be continuously used for 15 days. Specific implementation mode

[0032] Example 1

[0033] Preparation of this traditional Chinese medicine hot compress formula (warming yang green salt hot compress package) for treating lumbar disc herniation of qi stagnation and blood stasis type:

[0034] Take 30g of deer tendon, 20g of tetragonal rattan, 20g of nine-dragon rattan, 20g of kadsura coccinea, 15g of cinnamon twig, 15g of clematis root, 15g of ledebouriella root, 15g of prepared common monkshood mother root, 15g of prepared kusnezoff monkshood root, 15g of cyathula root, 15g of incised notopterygium root, 15g of lycopodium clavatum, 15g of dragon's blood, 10g of safflower, 2g of camphor, 2g of borneol. The various traditional Chinese medicines are ground into coarse powder and mixed with 1000g of large green salt and packed into bags to obtain a hot compress package. Before use, the hot compress package is heated in a microwave oven on medium heat and then applied to the affected area until the medicine package cools down. It is applied once in the morning and once in the evening every day, and each package can be continuously used for 15 days.

[0035] Example 2

[0036] Clinical efficacy observation

[0037] 1. Clinical data

[0038] 1.1 General information: 58 patients with lumbar disc herniation of blood stasis and qi stagnation type who were hospitalized in Lu'an People's Hospital from January 2024 to December 2024 were selected as the research objects. They were randomly divided into a control group and a treatment group according to the random number table, with 29 cases in each group. The general information of the patients between the two groups, including age and gender, had no statistical difference (P>0.05), and they were comparable. This study has been reviewed and approved by the hospital ethics committee.

[0039] 1.2 Inclusion and exclusion criteria:

[0040] 1.2.1 Inclusion criteria: (1) Meeting the diagnostic criteria for lumbar intervertebral disc herniation of qi stagnation and blood stasis type. The western medicine diagnostic criteria refer to the "Diagnosis and Treatment Guidelines for Lumbar Intervertebral Disc Herniation"; the TCM syndrome differentiation criteria for qi stagnation and blood stasis syndrome refer to the "TCM Clinical Diagnosis and Treatment Terms - Syndrome Part" of the National Standard of the People's Republic of China in 1997; (2) Aged between 18 and 60 years old; (3) Not having received hormone treatment or taken medications in the past 3 months; (4) Voluntarily participating in this study and signing the informed consent form for clinical research.

[0041] 1.2.2 Exclusion criteria: (1) Those who have received other local TCM and western medicine treatments 1 month before enrollment; (2) Those with other lumbar and lower limb diseases such as spinal canal stenosis, spondylolisthesis, and deformities; (3) Those with concurrent infections or malignant tumors; (4) Pregnant and lactating women; (5) Patients with a history of lumbar intervertebral disc herniation surgery; (6) Those who are receiving other relevant treatments and may affect the results of this study.

[0042] 1.2.3 Termination criteria: (1) Those who cannot cooperate with the treatment according to the course or request to withdraw by themselves; (2) Those who cannot cooperate with the follow-up evaluation; (3) Those who have adverse reactions such as skin allergies and burns during the treatment process.

[0043] 2. Treatment methods

[0044] (1) Control group: The control group was treated with non-steroidal anti-inflammatory drugs for pain relief. Oral celecoxib capsules (Qingdao Baiyang Pharmaceutical Co., Ltd., specification 0.2g×2 capsules) were taken, 1 capsule for adults once a day, and taken continuously for 2 weeks as 1 course. Before taking the medicine and 1 week after taking the medicine, liver and kidney functions were regularly rechecked, and the medicine was stopped immediately if there was any discomfort.

[0045] (2) Treatment group: The treatment site was the middle part of the waist. The traditional Chinese medicine hot compress package obtained in Example 1 was taken, heated with a 600W microwave oven for 2 minutes; the patient could lie flat or prone, and the traditional Chinese medicine hot compress package could be pressed under the body or spread on the waist. The affected skin could directly contact the traditional Chinese medicine package. If it was too hot, it could be separated by clothes or towels. When the back of the hand felt that the traditional Chinese medicine package was not hot, it was the best temperature, 2 times a day, 20 minutes each time. After applying the traditional Chinese medicine package, the used traditional Chinese medicine package was stored in a cool place, and each medicine package could be reused for 15 days as 1 course.

[0046] 3. Observation indicators

[0047] The following 3 clinical observation indicators of the patients were compared respectively to evaluate the treatment effect.

[0048] 3.1 Clinical efficacy: According to the "Diagnostic and Therapeutic Efficacy Criteria for TCM Diseases and Syndromes", it was divided into 4 grades. Cure: Symptoms and signs completely recovered, and the waist and leg activities were normal; Marked effect: Symptoms and signs improved, and the waist and leg activities were basically normal; Effective: Symptoms, signs and waist and leg activities improved compared with before; Ineffective: Symptoms, signs and waist and leg activities did not show obvious improvement.

[0049] Total effective rate = (cure rate + marked effective rate + effective rate) / total number of cases * 100%.

[0050] 3.2 Visual Analogue Scale (VAS) for pain: Before and after treatment, the low back and leg pain was evaluated using a calibrated scale marked from 0 to 10 from left to right. 0 indicates no pain, and 10 indicates the most severe pain. The higher the score, the more severe the pain.

[0051] 3.3 Oswestry Disability Index (ODI) of the lumbar spine: It is divided into 10 evaluations including pain level, self-care ability, weight bearing, walking, etc., with each item scored from 0 to 5 points, and the highest score is 50 points. Assessments were performed before and after treatment. ODI index = (score obtained / 50) / 100.

[0052] 4. In this study, SPSS 23.0 was used for between-group comparisons among samples. Parametric tests were used for data with normal distribution or approximately normal distribution after logarithmic transformation. The t-test was used for comparisons between two groups, and analysis of variance was used for comparisons among multiple groups, and post hoc tests were performed based on the Bonferroni method. Non-parametric tests were used for data with non-normal distribution. The t-test was used for comparisons, and P < 0.05 was considered statistically significant, while P > 0.05 was considered not statistically significant.

[0053] 5. Results

[0054] Table 1 General conditions of two groups of patients

[0055]

[0056] Table 2 Comparison of clinical efficacy between two groups of patients

[0057]

[0058] Note: * Compared with the same group, P < 0.05

[0059] Table 3 VAS scores (X±s) of two groups of patients before and after treatment

[0060]

[0061] Note: * Compared with before and after treatment in the same group, P < 0.05

[0062] Table 4 ODI scores (X±s) of two groups of patients before and after treatment

[0063]

[0064] Note: * Compared with before and after treatment in the same group, P < 0.05

[0065] 6. Summary and Discussion

[0066] According to the observed clinical indicators, after 4 weeks of treatment, in terms of the VAS score, ODI score, and the effective rate of the patients in both groups, it can be seen that all indicators of the observation group and the treatment group have improved before and after treatment. However, the improvement indicators of the treatment group are significantly better than those of the observation group (P < 0.05), and the difference is statistically significant. Therefore, the experiment shows that the traditional Chinese medicine hot compress pack can relieve the pain of lumbar disc herniation, and the improvement effect is better than that of celecoxib, and the effect is more obvious.

[0067] The above content is only an example and explanation of the concept of the present invention. Those skilled in the art of the present technology can make various modifications or supplements to the specific embodiments described or use similar methods for substitution. As long as they do not deviate from the concept of the invention or exceed the scope defined by this claim book, they should belong to the protection scope of the present invention.

Claims

1. A traditional Chinese medicine hot compress formula for treating lumbar disc herniation of qi stagnation and blood stasis type, characterized in that, It is composed of traditional Chinese medicine raw materials with the following weights: Deer tendon 15 - 50 g, Tetrastigma siamense 10 - 25 g, Entada phaseoloides 15 - 25 g, Kadsura coccinea 10 - 25 g, Cinnamon twig 10 - 20 g, Clematis chinensis 12 - 16 g, Saposhnikovia divaricata 12 - 18 g, Radix Aconiti preparata 14 - 16 g, Radix Aconiti Kusnezoffii preparata 14 - 16 g, Cyathula officinalis 5 - 20 g, Notopterygium incisum 10 - 20 g, Lycopodium clavatum 10 - 20 g, Dragon's blood 12 - 17 g, Carthamus tinctorius 5 - 12 g, Borneol 1 - 3 g, Camphor 1 - 5 g; Coarsely powder each traditional Chinese medicine, mix it with an appropriate amount of halite and pack it into a bag to obtain a hot compress pack.

2. The traditional Chinese medicine hot compress prescription for treating lumbar disc herniation of qi stagnation and blood stasis type according to claim 1, wherein It is composed of traditional Chinese medicine raw materials with the following weights: Deer tendon 30 g, Tetrastigma siamense 20 g, Entada phaseoloides 20 g, Kadsura coccinea 20 g, Cinnamon twig 15 g, Clematis chinensis 15 g, Saposhnikovia divaricata 15 g, Radix Aconiti preparata 15 g, Radix Aconiti Kusnezoffii preparata 15 g, Cyathula officinalis 15 g, Notopterygium incisum 15 g, Lycopodium clavatum 15 g, Dragon's blood 15 g, Carthamus tinctorius 10 g, Borneol 2 g, Camphor 2 g; Coarsely powder each traditional Chinese medicine, mix it with 1000 g of halite and pack it into a bag to obtain a hot compress pack.

3. Use of the traditional Chinese medicine hot compress formula as claimed in claim 1 or 2 in the medicament for treating lumbar intervertebral disc herniation of qi stagnation and blood stasis type, characterized in that, Before use, put the hot compress pack into a microwave oven and heat it on medium heat, then apply it to the affected area until the medicine pack cools. Do this once in the morning and once in the evening every day, and each pack can be continuously used for 15 days.

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