Adaptive radiotherapy assessment method and device, and storage medium

Abstract

The invention provides a self-adaptive radiotherapy assessment method and device and a storage medium, and relates to the technical field of radiotherapy. The method comprises the following steps: acquiring a real-time image of a target volume, wherein the target volume comprises a target region and / or an organ at risk; determining the contour of the deformed target volume based on the real-time image of the target volume and the planned reference image of the target volume, and performing dose calculation based on the contour of the deformed target volume and the first dose parameter to obtain a second dose parameter matched with the deformed target volume; the first dose parameter is a dose parameter for making a treatment plan for a target volume in the planned reference image; and determining that the second dose parameter meets the dose evaluation requirement, and indicating that adaptive radiotherapy does not need to be performed on the target volume. According to the invention, whether self-adaptive radiotherapy needs to be carried out can be evaluated and indicated, so that unnecessary resources are prevented from being consumed, and the workload of medical personnel and the treatment duration of a patient are reduced.

Description

Technical Field

[0001] This application relates to the field of radiotherapy technology, and in particular, to an evaluation method, device, and storage medium for adaptive radiotherapy. Background Art

[0002] Adaptive radiotherapy (ART) can dynamically adjust the radiotherapy plan according to the changes in the target volume and organs at risk (OAR) of the target object during the treatment process, so as to achieve a more accurate radiation dose matching.

[0003] However, before each radiotherapy, it is necessary to re-contour the target volume and organs at risk based on real-time images, optimize the original treatment plan to obtain a new ART plan, and evaluate the new ART plan. This inevitably increases the workload of medical staff and the treatment duration of patients. Summary of the Invention

[0004] This application provides an evaluation method, device, and storage medium for adaptive radiotherapy, which can evaluate and indicate whether adaptive radiotherapy is required, so as to avoid consuming unnecessary resources, reducing the workload of medical staff and the treatment duration of patients.

[0005] To achieve the above object, this application adopts the following technical solutions:

[0006] In a first aspect, this application provides an evaluation method for adaptive radiotherapy, the method includes: obtaining a real-time image of a target volume, the target volume including a target area and / or an organ at risk; based on the real-time image of the target volume and the planned reference image of the target volume, determining the contour of the deformed target volume, and performing dose calculation based on the contour of the deformed target volume and a first dose parameter to obtain a second dose parameter that matches the deformed target volume; the first dose parameter is a dose parameter for formulating a treatment plan for the target volume in the planned reference image; determining that the second dose parameter meets the dose evaluation requirements, indicating that adaptive radiotherapy for the target volume is not required.

[0007] Combined with the above first aspect, in a possible implementation manner, the above method for determining the contour of the deformed target volume based on the real-time image of the target volume and the planned reference image of the target volume includes: performing deformation registration on the real-time image of the target volume and the planned reference image of the target volume to determine the deformation amount of the target volume; the deformation amount of the target volume is the deformation amount of the target volume in the real-time image relative to the target volume in the planned reference image; based on the deformation amount of the target volume and the planned reference image of the target volume, determining the contour of the deformed target volume.

[0008] Combined with the first aspect above, in a possible implementation manner, determining the contour of the deformed target volume based on the deformation amount of the target volume and the planned reference image of the target volume includes: applying the deformation amount of the target volume to the planned reference image of the target volume to determine the contour of the deformed target volume in the planned reference image; or mapping the contour of the target volume in the planned reference image to the real-time image, applying the deformation amount of the target volume to the real-time image of the target volume to determine the contour of the deformed target volume in the real-time image.

[0009] Combined with the first aspect above, in a possible implementation manner, the method further includes: determining that the second dose parameter does not meet the dose evaluation requirement, and indicating that adaptive radiotherapy needs to be performed on the target volume.

[0010] Combined with the first aspect above, in a possible implementation manner, the first dose parameter includes the prescribed dose of the target area before deformation and / or the first dose acceptance limit of the organ at risk before deformation, and the second dose parameter includes the dose of the target area after deformation and / or the second dose acceptance limit of the organ at risk after deformation.

[0011] Combined with the first aspect above, in a possible implementation manner, the dose evaluation requirement is that the difference between the first dose parameter and the second dose parameter is within a preset threshold range.

[0012] Combined with the first aspect above, in a possible implementation manner, the need to perform adaptive radiotherapy on the target volume includes: obtaining the contour of the target volume in the real-time image; generating an adaptive radiotherapy plan based on the contour of the target volume.

[0013] In a second aspect, the present application provides an evaluation device for adaptive radiotherapy. The device includes: a communication unit and a processing unit; the communication unit is used to obtain a real-time image of the target volume, and the target volume includes a target area and / or an organ at risk; the processing unit is used to determine the contour of the deformed target volume based on the real-time image of the target volume and the planned reference image of the target volume, and perform dose calculation based on the contour of the deformed target volume and the first dose parameter to obtain a second dose parameter that matches the deformed target volume; the first dose parameter is a dose parameter for formulating a treatment plan for the target volume in the planned reference image; the processing unit is further used to determine that the second dose parameter meets the dose evaluation requirement and indicate that adaptive radiotherapy does not need to be performed on the target volume.

[0014] Combined with the above second aspect, in a possible implementation, the processing unit is specifically configured to: perform deformation registration on the real-time image of the target volume and the planned reference image of the target volume to determine the deformation amount of the target volume; the deformation amount of the target volume is the deformation amount of the target volume in the real-time image relative to the target volume in the planned reference image; based on the deformation amount of the target volume and the planned reference image of the target volume, determine the contour of the deformed target volume.

[0015] Combined with the above second aspect, in a possible implementation, the processing unit is specifically configured to: apply the deformation amount of the target volume to the planned reference image of the target volume to determine the contour of the deformed target volume in the planned reference image; or, map the contour of the target volume in the planned reference image to the real-time image, apply the deformation amount of the target volume to the real-time image of the target volume, and determine the contour of the deformed target volume in the real-time image.

[0016] Combined with the above second aspect, in a possible implementation, the processing unit is further configured to: determine that the second dose parameter does not meet the dose evaluation requirement, and indicate that adaptive radiotherapy needs to be performed on the target volume.

[0017] Combined with the above second aspect, in a possible implementation, the first dose parameter includes the prescribed dose of the target area before deformation and / or the first dose acceptance limit of the organ at risk before deformation, and the second dose parameter includes the dose of the target area after deformation and / or the second dose acceptance limit of the organ at risk after deformation.

[0018] Combined with the above second aspect, in a possible implementation, the dose evaluation requirement is that the difference between the first dose parameter and the second dose parameter is within a preset threshold range.

[0019] Combined with the above second aspect, in a possible implementation, the processing unit is further configured to: obtain the contour of the target volume in the real-time image; based on the contour of the target volume, generate an adaptive radiotherapy plan.

[0020] In a third aspect, the present application provides an electronic device, which includes: a processor and a memory configured to store processor-executable instructions; wherein, the processor is configured to execute the instructions to implement the evaluation method of adaptive radiotherapy described in the first aspect and any possible implementation manner of the first aspect.

[0021] In a fourth aspect, the present application provides a computer-readable storage medium, in which instructions are stored, and when the instructions are run on a terminal, the terminal is caused to execute the evaluation method of adaptive radiotherapy described in the first aspect and any possible implementation manner of the first aspect.

[0022] Fifth aspect, the present application provides a computer program product including instructions. The computer program product includes computer instructions, which, when running on a computer, cause the computer to execute the evaluation method of adaptive radiotherapy described in the first aspect and any possible implementation manner of the first aspect.

[0023] Sixth aspect, the present application provides a chip, which includes a processor and a communication interface. The communication interface is coupled to the processor, and the processor is configured to run a computer program or instructions to implement the evaluation method of adaptive radiotherapy described in the first aspect and any possible implementation manner of the first aspect.

[0024] Specifically, the chip provided in the present application further includes a memory for storing a computer program or instructions.

[0025] It should be noted that the above computer instructions can be stored in whole or in part on a computer-readable storage medium. The computer-readable storage medium can be packaged together with the processor of the device or separately packaged from the processor of the device. The present application does not make any limitation in this regard.

[0026] Seventh aspect, the present application provides a radiotherapy system, including: a simulation positioning device, a radiotherapy planning device, a control computer device, and a radiotherapy device. The radiotherapy planning device is configured to execute the evaluation method of adaptive radiotherapy described in the first aspect and any possible implementation manner of the first aspect.

[0027] The descriptions of the second to seventh aspects in the present application can refer to the detailed description of the first aspect; and the beneficial effects of the descriptions of the second to seventh aspects can refer to the analysis of the beneficial effects of the first aspect, which will not be elaborated here.

[0028] In the present application, the name of the above evaluation device of adaptive radiotherapy does not constitute a limitation to the device or functional module itself. In actual implementation, these devices or functional modules may appear under other names. As long as the functions of each device or functional module are similar to those of the present application and fall within the scope of the claims of the present application and equivalent technologies.

[0029] These aspects or other aspects of the present application will be more clearly understood in the following description.

[0030] The evaluation method for adaptive radiotherapy provided by this application first obtains real-time images of the target volume, that is, real-time images of the target area and / or organs at risk. Then, based on the real-time images of the target volume and the planned reference images of the target volume, the contour of the deformed target volume is determined. Furthermore, based on the contour of the deformed target volume and the first dose parameters for formulating the treatment plan for the target volume in the planned reference images, dose calculation is performed, and the second dose parameters matching the deformed target volume can be obtained. In this way, even if the target volume changes before this radiotherapy, as long as it is determined that the second dose parameters meet the dose evaluation requirements, it can be indicated that there is no need to perform adaptive radiotherapy on the target volume, assisting the user in making decisions to avoid unnecessary adaptive radiotherapy, saving resources and reducing the workload of medical staff.

[0031] And since there is no need to perform adaptive radiotherapy, there is no need to re-delineate the contours of the target area and organs at risk and generate a new ART plan. Then, medical staff do not need to evaluate the new ART plan, reducing the workload of medical staff and shortening the treatment duration of patients. Brief Description of the Drawings

[0032] Figure 1 It is a schematic architecture diagram of a radiotherapy system provided by an embodiment of this application;

[0033] Figure 2 It is a flowchart of an evaluation method for adaptive radiotherapy provided by an embodiment of this application;

[0034] Figure 3 It is a flowchart of another evaluation method for adaptive radiotherapy provided by an embodiment of this application;

[0035] Figure 4 It is a schematic structural diagram of an evaluation device for adaptive radiotherapy provided by an embodiment of this application;

[0036] Figure 5 It is a schematic hardware structure diagram of an electronic device provided by an embodiment of this application. Detailed Embodiments

[0037] Next, the technical solutions in the embodiments of this application will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of this application. Obviously, the described embodiments are only a part of the embodiments of this application, rather than all the embodiments. Based on the embodiments in this application, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of this application.

[0038] As used herein, the term "and / or" is merely a description of the relationship between associated objects, indicating that there can be three relationships. For example, A and / or B can represent three cases: A exists alone, A and B exist simultaneously, and B exists alone.

[0039] In the description of the present application and the accompanying drawings, terms such as "first" and "second" are used to distinguish different objects or different treatments of the same object, rather than to describe a specific order of the objects.

[0040] In addition, the terms "comprising" and "having" and any variations thereof mentioned in the description of the present application are intended to cover non-exclusive inclusion. For example, a process, method, system, product, or device that includes a series of steps or units is not limited to the listed steps or units, but may optionally further include other unlisted steps or units, or may optionally further include other steps or units inherent to these processes, methods, products, or devices.

[0041] It should be noted that in the embodiments of the present application, words such as "exemplary" or "for example" are used to represent examples, illustrations, or explanations. Any embodiment or design solution described as "exemplary" or "for example" in the embodiments of the present application should not be construed as being more preferred or having more advantages than other embodiments or design solutions. Rather, the use of words such as "exemplary" or "for example" is intended to present relevant concepts in a specific manner.

[0042] In the description of the present application, unless otherwise specified, the meaning of "a plurality of" refers to two or more.

[0043] During the process of a patient (also referred to as the target object) receiving radiotherapy, many changes will occur inside the body. On the one hand, the physiological state of the target object will continuously change, such as weight gain or loss, natural peristalsis and displacement of organs, etc.; on the other hand, the shape and size of the tumor itself will change with the treatment process. These dynamic changes pose a great challenge to the accuracy of radiotherapy. Traditional radiotherapy plans are determined before the treatment starts and are difficult to adapt to the changes during these processes, which may result in insufficient dose received by the tumor site (target area), affecting the treatment effect, or unnecessary radiation to the surrounding normal tissues (organs at risk (OAR)), causing side effects.

[0044] Adaptive radiotherapy (ART) determines the changes in the physiological state, target volume, and the shape of organs at risk of the target object during the treatment process by acquiring real-time image data of the target object (e.g., computed tomography (CT) images, cone-beam computed tomography (CBCT) images, magnetic resonance (MR) images), and then dynamically adjusts the radiotherapy plan, thereby achieving more precise radiation dose matching, reducing side effects, and improving the overall treatment effect.

[0045] Specifically, each fractionated radiotherapy in adaptive radiotherapy can achieve the generation of an adaptive radiotherapy plan through the following steps 1 - 3.

[0046] Step 1: Acquire real-time images.

[0047] Within a short period before the current radiotherapy, acquire the real-time images of the target object to monitor the changes in the target volume and the organs at risk of the target object.

[0048] Step 2: Generate an adaptive radiotherapy plan.

[0049] Upload the real-time images to the treatment planning system (TPS). In the radiotherapy planning system, based on the real-time images of the target object, re-contour and adjust the target volume and the organs at risk, and optimize the dose parameters of the original treatment plan to obtain a new adaptive radiotherapy plan.

[0050] Step 3: Evaluate the adaptive radiotherapy plan.

[0051] Evaluate the new adaptive radiotherapy plan to ensure the safety and accuracy of the target volume and the organs at risk under the new adaptive radiotherapy plan.

[0052] For example, it can be through the way of manual confirmation, or by using computational models and simulation techniques, to check whether the target volume can obtain sufficient and uniform dose to achieve effective killing under the new adaptive radiotherapy plan, while ensuring that the dose received by the surrounding organs at risk is within the safe threshold range.

[0053] Although the advantages of adaptive radiotherapy are obvious, during the above-mentioned adaptive radiotherapy process, before each radiotherapy, it is necessary to re-contour the target volume and the organs at risk based on real-time images, optimize the original treatment plan to obtain a new ART plan, and evaluate the new ART plan, which inevitably increases the workload of medical staff and the treatment duration of patients.

[0054] In view of this, the present application proposes an evaluation method for adaptive radiotherapy. First, a real-time image of the target volume, that is, a real-time image of the target area and / or organs at risk, is acquired. Then, based on the real-time image of the target volume and the planned reference image of the target volume, the contour of the deformed target volume is determined. Furthermore, based on the contour of the deformed target volume and the first dose parameter for formulating a treatment plan for the target volume in the planned reference image, dose calculation is performed, and thus the second dose parameter matching the deformed target volume can be obtained. In this way, even if the target volume changes before this radiotherapy, as long as it is determined that the second dose parameter meets the dose evaluation requirements, it can be indicated that adaptive radiotherapy for the target volume is not required, assisting the user in decision-making to avoid unnecessary adaptive radiotherapy, saving resources and reducing the workload of medical staff.

[0055] Moreover, since adaptive radiotherapy is not required, there is no need to re-delineate the contours of the target area and organs at risk and generate a new ART plan. Then, medical staff do not need to evaluate the new ART plan, reducing the workload of medical staff and shortening the treatment duration of patients.

[0056] The following will describe in detail the implementation manners of the embodiments of the present application with reference to the accompanying drawings of the specification.

[0057] It should be noted that the embodiments of the present application can be mutually borrowed or referenced. For example, the same or similar steps, method embodiments, system embodiments, and device embodiments can all be mutually referenced without limitation.

[0058] Figure 1 FIG. is a schematic architecture diagram of a radiotherapy system provided by an embodiment of the present application. The radiotherapy system may include: a simulation positioning device 101, a radiotherapy planning device 102, a control computer device 103, and a radiotherapy device 104.

[0059] Among them, the simulation positioning device 101 is a device for collecting images of the tumor site and surrounding normal tissues of a target object (such as a patient to be treated, an experimental object, a phantom, etc.). In some embodiments, the simulation positioning device 101 may be at least one of devices such as a computed tomography (CT) device, an emission computed tomography (ECT) device, a magnetic resonance imaging (MRI) device, a positron emission tomography (PET) device, and an ultrasonic examination device.

[0060] The radiotherapy device 104 is a device for performing radiotherapy on a target object. In some embodiments, the radiotherapy device 104 may include a gantry 1041, a treatment head 1042, an image guidance device 1043, and a support device 1044.

[0061] Among them, the gantry 1041 may be a rotatable gantry. The treatment head 1042 may be disposed on the gantry and is used to emit a radiation beam to irradiate the object to be irradiated, such as gamma rays, MV-class X-rays, proton rays, etc. For example, the treatment head 1042 may be any two of a gamma knife treatment head for rotational focused radiotherapy, an accelerator treatment head for intensity-modulated radiotherapy, or other radiotherapy heads. In the embodiments of the present application, the treatment head 1042 may correspond to different radiotherapy modes, and the radiotherapy modes are respectively, such as rotational focused radiotherapy and intensity-modulated radiotherapy. The image guidance device 1043 is used to obtain a real-time image of the target volume, where the target volume includes a target area and organs at risk, and perform real-time image guidance during the positioning and radiotherapy of the object to be radiated. Exemplarily, the image guidance device 1043 includes an X-ray tube 1043A and a detector 1043B. The detector 1043B can receive the imaging beam emitted by the X-ray tube 1043A that passes through the target object and generate a geometric position image, and this geometric position image is used to indicate the shape and / or position of the target area of the target object; the support device 1044 is used to support the target object and may be a treatment couch.

[0062] In some embodiments, when the target object is on the support device 1044, the rotation of the gantry 1041 can drive the treatment head 1042 to irradiate the target object 360 degrees, thereby completing the radiotherapy.

[0063] The radiotherapy planning device 102 is a device for obtaining a planned reference image of the target object from the simulation positioning device 101 and a real-time image of the target object from the image guidance device 1043 in the radiotherapy device 104 to formulate, optimize, and evaluate a radiotherapy plan. Among them, the radiotherapy planning device 102 can run a treatment planning system (TPS), and this treatment planning system provides functions for formulating, optimizing, and evaluating a radiotherapy plan, such as generating an adaptive radiotherapy plan. For example, the RT pro TPS system.

[0064] In some embodiments, the radiotherapy planning device 102 may include a TPS client 1021 and a TPS server 1022.

[0065] Among them, the TPS client 1021 can be at least one of devices such as a smart phone, a smart watch, a desktop computer, a laptop computer, a virtual reality terminal, an augmented reality terminal, a wireless terminal, and a laptop portable computer. For example, in some embodiments, the radiotherapy planning system run by the TPS client 1021 on the TPS server 1022 can trigger the TPS server 1022 to execute an adaptive radiotherapy plan optimization process and display the optimized radiotherapy plan. In this way, it can effectively save the user's time and can more intuitively present the optimized treatment plan for the user to evaluate the radiotherapy plan.

[0066] Among them, the TPS server 1022 can be an independent physical server, or a server cluster or a distributed file system composed of multiple physical servers, or at least one of cloud servers that provide basic cloud computing services such as cloud services, cloud databases, cloud computing, cloud functions, cloud storage, network services, cloud communications, middleware services, domain name services, security services, content delivery networks, and big data or artificial intelligence platforms. The embodiments of the present disclosure do not limit this. In some embodiments, the number of the above-mentioned TPS servers 1022 can be more or less, and the embodiments of the present disclosure do not limit this. Of course, the TPS server 1022 can also include other functions to provide more comprehensive and diverse services. In some embodiments, the TPS server 1022 is used to provide background services for the above-mentioned TPS client 1021, such as executing an adaptive radiotherapy plan optimization process.

[0067] In the embodiment of the present application, the radiotherapy planning device 102 is used to obtain a real-time image of a target volume, where the target volume includes a target area and / or an organ at risk; based on the real-time image of the target volume and the planned reference image of the target volume, determine the contour of the deformed target volume, and perform dose calculation based on the contour of the deformed target volume and a first dose parameter to obtain a second dose parameter that matches the deformed target volume, where the first dose parameter is a dose parameter for formulating a treatment plan for the target volume in the planned reference image; determine that the second dose parameter meets the dose evaluation requirements and indicate that adaptive radiotherapy for the target volume is not required.

[0068] The control computer device 103 is a device used to control the radiotherapy device 104 to execute radiotherapy plans (including the original treatment plan and the adaptive radiotherapy plan).

[0069] In some embodiments, the control computer device 103 may include a host computer and a slave computer. The host computer is used for interacting with the user, and the slave computer is used for controlling the movement of each moving part in the radiotherapy device 104. The host computer may be at least one of devices such as a smart phone, a smart watch, a desktop computer, a laptop computer, a virtual reality terminal, an augmented reality terminal, a wireless terminal, and a laptop portable computer and / or a server device. The slave computer may be a control device such as a programmable logic controller (PLC).

[0070] Above, the radiotherapy system in the embodiments of the present application has been introduced.

[0071] Figure 2 It is a flowchart of an evaluation method for adaptive radiotherapy provided by an embodiment of the present application. As Figure 2 shown, the method includes the following steps:

[0072] S201. Obtain a real-time image of the target volume.

[0073] Among them, the target volume includes a target area and / or an organ at risk. The real-time image of the target volume may be a real-time image collected for the target volume before radiotherapy.

[0074] It should be noted that the contour of the target volume is not outlined in the real-time image of the target volume, that is, the contour of the target area and / or the contour of the organ at risk are not outlined in the real-time image.

[0075] S202. Based on the real-time image of the target volume and the planned reference image of the target volume, determine the contour of the deformed target volume.

[0076] Among them, the planned reference image of the target volume is the image used for formulating the treatment plan. It may be the image used for generating the initial treatment plan, such as the image containing the target volume obtained by the simulation positioning device, or the image used for generating the previous or more previous treatment plan. The contour of the target volume has been outlined in the planned reference image of the target volume, that is, the contour of the target area and the contour of the organ at risk. In this way, based on the contour of the target volume outlined in the planned reference image, the contour of the deformed target volume can be determined.

[0077] Optionally, the planned reference image may be a CT image, a CBCT image, or an MRI image, and the present application does not limit this.

[0078] In a possible implementation, the implementation process of S202 includes: performing deformation registration on the real-time image of the target volume and the planned reference image of the target volume to determine the deformation amount of the target volume; based on the deformation amount of the target volume and the planned reference image of the target volume, determining the contour of the deformed target volume. Wherein, the deformation amount of the target volume is the deformation amount of the target volume in the real-time image relative to the target volume in the planned reference image.

[0079] Exemplarily, when the target volume is located in the first part of the patient (for example, the body part), since the target volume located in the body part is prone to deformation over time, therefore, deformation registration can be performed on the real-time image of the target volume and the planned reference image of the target volume, and then the deformation amount of the target volume can be determined, that is, the deformation amount of the target volume in the real-time image relative to the target volume in the planned reference image can be determined.

[0080] Further, after performing deformation registration on the real-time image of the target volume and the planned reference image of the target volume to determine the deformation amount of the target volume, the deformation amount of the target volume can be applied to the planned reference image of the target volume or the real-time image of the target volume to determine the contour of the deformed target volume.

[0081] In another possible implementation, the implementation process of S202 includes: based on the manual delineation method, the contour of the deformed target volume can be delineated in the real-time image of the target volume and / or the planned reference image of the target volume.

[0082] It should be understood that since the contour of the target volume is not delineated in the real-time image, therefore, the contour of the deformed target volume can be determined through the above S202, so that in S203, the first dose parameter can be dose-calculated based on the contour of the deformed target volume, and then the second dose parameter matching the deformed target volume can be obtained.

[0083] S203: Perform dose calculation based on the contour of the deformed target volume and the first dose parameter to obtain a second dose parameter that matches the deformed target volume.

[0084] Wherein, the first dose parameter is the dose parameter for formulating a treatment plan for the target volume in the planned reference image.

[0085] Optionally, the first dose parameter includes the prescription dose of the target area before deformation and / or the first dose acceptance limit of the organ at risk before deformation, and the second dose parameter includes the dose of the target area after deformation and / or the second dose acceptance limit of the organ at risk after deformation.

[0086] In a possible implementation, the first dose parameter is applied to the contour of the deformed target volume to obtain the dose distribution of the first dose parameter in the deformed target volume (hereinafter, simply referred to as the deformed dose distribution). At this time, since the first dose parameter is the dose parameter set for the target volume before deformation, and the target volume has deformed, the deformed dose distribution may be uneven, and dose calculation needs to be performed again. Furthermore, based on a dose algorithm (such as a convolution superposition algorithm, a Monte Carlo simulation algorithm), dose calculation is performed on the deformed dose distribution, and a second dose parameter can be obtained.

[0087] S204. Determine that the second dose parameter meets the dose evaluation requirements, and indicate that adaptive radiotherapy for the target volume is not required.

[0088] In some embodiments, the dose evaluation requirement is that the difference between the first dose parameter and the second dose parameter is within a preset threshold range. Among them, the preset threshold range can be set according to the actual situation, and the present application does not make any restrictions on this.

[0089] In a possible implementation, taking the difference between the first dose parameter and the second dose parameter (for example, the average value of the ratio between the first dose parameter and the second dose parameter) as 92% and the preset threshold range as greater than or equal to 90%, it can be determined that the second dose parameter meets the dose evaluation requirements, and further indicate that adaptive radiotherapy for the target volume is not required.

[0090] Optionally, the difference between the first dose parameter and the second dose parameter may include at least one of the following: the ratio between the first dose parameter and the second dose parameter, the difference between the first dose parameter and the second dose parameter, the average value of the ratio between the first dose parameter and the second dose parameter, and the value obtained by weighted summation of the difference between the first dose parameter and the second dose parameter.

[0091] In an example, the ratio between the first dose parameter and the second dose parameter may include: the first ratio of the prescription dose of the target area before deformation to the prescription dose of the target area after deformation, and / or the second ratio of the first dose acceptance limit of the organ at risk before deformation to the second dose acceptance limit of the organ at risk after deformation.

[0092] It should be understood that the ratio between the first dose parameter and the second dose parameter can effectively reflect the proportion of the second dose parameter in the first dose parameter. For example, the first ratio of the prescribed dose of the target area before deformation and the prescribed dose of the target area after deformation can reflect the proportion of the prescribed dose of the target area after deformation in the prescribed dose of the target area before deformation. Furthermore, if the first ratio is outside the preset threshold range (for example, less than 90%, where the preset threshold range is greater than or equal to 90%), then it can be indicated that the treatment effect of the prescribed dose of the target area after deformation is poor. Therefore, adaptive radiotherapy needs to be performed on the target volume. On the contrary, if the first ratio is within the threshold range (for example, greater than or equal to 90%), then it can be indicated that the treatment effect of the prescribed dose of the target area after deformation is good. Therefore, adaptive radiotherapy does not need to be performed on the target volume.

[0093] In another example, the average value of the ratio between the first dose parameter and the second dose parameter can be the average value of the first ratio and the second ratio.

[0094] In another example, the difference between the first dose parameter and the second dose parameter may include: the first difference between the prescribed dose of the target area before deformation and the prescribed dose of the target area after deformation, and / or the second difference between the first dose acceptance limit of the organ at risk before deformation and the second dose acceptance limit of the organ at risk after deformation.

[0095] It should be understood that the difference between the first dose parameter and the second dose parameter can effectively reflect the deviation of the second dose parameter compared with the first dose parameter. For example, the first difference between the prescribed dose of the target area before deformation and the prescribed dose of the target area after deformation can reflect the deviation of the prescribed dose of the target area after deformation compared with the prescribed dose of the target area before deformation. Furthermore, if the first difference is outside the preset threshold range (for example, greater than or equal to 5 Gy, where the preset threshold range is less than 5 Gy), then it can be indicated that the treatment effect of the prescribed dose of the target area after deformation is poor. Therefore, adaptive radiotherapy needs to be performed on the target volume. On the contrary, if the first difference is within the threshold range (for example, less than 5 Gy), then it can be indicated that the treatment effect of the prescribed dose of the target area after deformation is good. Therefore, adaptive radiotherapy does not need to be performed on the target volume.

[0096] In another example, the value obtained by weighted summation of the difference between the first dose parameter and the second dose parameter can be the value obtained by weighted summation of the first difference and the second difference. For example, taking the prescription dose of the target area before deformation in the first dose parameter as 50 Gray (Gy), and the first dose acceptance limit of the organ at risk before deformation as 10 Gy; the dose of the target area after deformation in the second dose parameter is 48 Gy, and the second dose acceptance limit of the organ at risk after deformation is 7 Gy as an example. The first difference is 2 Gy, and the second difference is 3 Gy. That is, the value obtained by weighted summation of the difference between the first dose parameter and the second dose parameter is: a*2 + b*3, where a and b are preset weights.

[0097] In some other embodiments, the dose evaluation requirement can also be that the prescription dose of the target area after deformation is greater than or equal to the first threshold, and / or the second dose acceptance limit of the organ at risk after deformation is less than the second threshold. Wherein, the first threshold and the second threshold are set according to the first dose parameter (that is, the prescription dose of the target area before deformation and the first dose acceptance limit of the organ at risk before deformation).

[0098] In one example, taking the prescription dose of the target area before deformation as 50 Gy and the first dose acceptance limit of the organ at risk before deformation as 10 Gy as an example, the first threshold can be set to 48 Gy, and the second threshold can be set to 8 Gy. Taking the dose of the target area after deformation in the second dose parameter as 48 Gy and the second dose acceptance limit of the organ at risk after deformation as 7 Gy as an example. Then it can be determined that the second dose parameter meets the dose evaluation requirement, and at this time, it is indicated that no adaptive radiotherapy is required for the target volume.

[0099] Based on the above technical solution, the present application proposes an evaluation method for adaptive radiotherapy. First, a real-time image of the target volume is obtained, that is, a real-time image of the target area and / or the organ at risk. Then, based on the real-time image of the target volume and the planned reference image of the target volume, the contour of the deformed target volume is determined. Furthermore, based on the contour of the deformed target volume and the first dose parameter for formulating the treatment plan for the target volume in the planned reference image, dose calculation is performed, and the second dose parameter matching the deformed target volume can be obtained. In this way, even if the target volume changes before this radiotherapy, as long as it is determined that the second dose parameter meets the dose evaluation requirement, it can be indicated that no adaptive radiotherapy is required for the target volume, assisting the user in making a decision to avoid unnecessary adaptive radiotherapy, saving resources and reducing the workload of medical staff.

[0100] And since no adaptive radiotherapy is required, there is no need to re-delineate the contours of the target area and the organ at risk and generate a new ART plan. Then, medical staff do not need to evaluate the new ART plan, reducing the workload of medical staff and shortening the treatment duration of patients.

[0101] Optionally, an evaluation method for adaptive radiotherapy provided by an embodiment of the present application may further include the following S205 (shown by a dotted line in the figure).

[0102] S205. Determine that the second dose parameter does not meet the dose evaluation requirements, and indicate that adaptive radiotherapy needs to be performed on the target volume.

[0103] In a possible implementation, when the difference between the first dose parameter and the second dose parameter (for example, the average value of the ratio between the first dose parameter and the second dose parameter) is 80%, and the preset threshold range is greater than or equal to 90%, it can be determined that the second dose parameter does not meet the dose evaluation requirements, and further indicate that adaptive radiotherapy needs to be performed on the target volume.

[0104] Furthermore, in some embodiments, if it is indicated that adaptive radiotherapy needs to be performed on the target volume, the contour of the target volume in the real-time image can be obtained; and based on the contour of the target volume, an adaptive radiotherapy plan can be generated.

[0105] In one example, the contour of the target volume in the real-time image can be determined based on the contour of the deformed target volume in S302. For example, if the contour of the deformed target volume in the real-time image is determined in S302, then the contour of the deformed target volume in the real-time image determined in S302 can be directly used as the contour of the target volume in the real-time image. In this way, the effective utilization of data resources can be realized. Another example, if the contour of the deformed target volume in the planned reference image is determined in S302, then the contour of the deformed target volume in the planned reference image can be mapped to the real-time image, and then the contour of the target volume in the real-time image can be obtained.

[0106] In another example, the contour of the target volume in the real-time image can also be determined by manual delineation.

[0107] In the above technical solution, when adaptive radiotherapy is required, indication information can also be provided to assist the user in making a decision.

[0108] As a possible embodiment of the present application, in combination with Figure 2 , as Figure 3 shown, the determination of the contour of the deformed target volume in the above S202 can be achieved through the following S301 - S302.

[0109] S301. Perform deformation registration on the real-time image of the target volume and the planned reference image of the target volume to determine the deformation amount of the target volume.

[0110] Wherein, the deformation amount of the target volume is the deformation amount of the target volume in the real-time image relative to the target volume in the planned reference image.

[0111] Optionally, the implementation process of S301 can specifically refer to the embodiment shown in S202, which will not be elaborated here.

[0112] S302. Determine the contour of the deformed target volume based on the deformation amount of the target volume and the planned reference image of the target volume.

[0113] In some other embodiments, the implementation manner of S302 (denoted as implementation manner 1) may include: mapping the contour of the target volume in the planned reference image to the real-time image, applying the deformation amount of the target volume to the real-time image of the target volume, and determining the contour of the deformed target volume in the real-time image.

[0114] Exemplarily, after mapping the contour of the target volume in the planned reference image to the real-time image, the contour of the target volume before deformation can be outlined in the real-time image. Furthermore, based on the deformation amount of the target volume, the contour of the target volume before deformation in the real-time image can be adjusted to determine the contour of the deformed target volume in the real-time image.

[0115] It should be understood that the above implementation manner 1 can determine the contour of the deformed target volume in the real-time image, so that the dose calculation can be performed based on the contour of the deformed target volume in the real-time image subsequently.

[0116] Moreover, when executing S205 to indicate that adaptive radiotherapy needs to be performed on the target volume, the contour of the deformed target volume determined in implementation manner 1 can be directly utilized, thereby improving the efficiency of adaptive treatment.

[0117] In some other embodiments, the implementation manner of S302 (i.e., implementation manner 2) may include: applying the deformation amount of the target volume to the planned reference image of the target volume and determining the contour of the deformed target volume in the planned reference image.

[0118] Exemplarily, based on the deformation amount of the target volume, the contour of the target volume in the planned reference image is adjusted to determine the contour of the deformed target volume in the planned reference image.

[0119] It should be understood that in Implementation Mode 2, the contour of the deformed target volume can be determined directly based on the contour of the target volume outlined in the planned reference image. Compared with the implementation process in Implementation Mode 1, where the contour of the target volume in the planned reference image is first mapped to the real-time image, and then the deformation amount of the target volume is applied to the real-time image of the target volume to determine the contour of the deformed target volume in the real-time image, Implementation Mode 2 can simplify the process of determining the contour of the deformed target volume, thereby reducing resource consumption and the treatment waiting time.

[0120] In the above technical solution, deformation registration can be performed on the real-time image of the target volume and the planned reference image of the target volume to determine the deformation amount of the target volume (i.e., the deformation amount of the target volume in the real-time image relative to the target volume in the planned reference image). Furthermore, based on the deformation amount of the target volume and the planned reference image of the target volume, the contour of the deformed target volume is determined. This provides data support for subsequent dose calculation of the first dose parameter based on the contour of the deformed target volume.

[0121] Embodiments of the present application can divide the functional modules or functional units of the evaluation device for adaptive radiotherapy according to the above method examples. For example, each functional module or functional unit can be corresponding to each function, or two or more functions can be integrated into one processing module. The above integrated module can be implemented in the form of hardware or in the form of a software functional module or functional unit. Among them, the division of modules or units in the embodiments of the present application is illustrative, only a logical function division, and there can be other division methods in actual implementation.

[0122] As Figure 4 shown, it is a schematic structural diagram of an evaluation device 40 for adaptive radiotherapy provided by an embodiment of the present application (hereinafter referred to as the evaluation device 40). The evaluation device 40 includes: a communication unit 401 and a processing unit 402.

[0123] The communication unit 401 is configured to obtain a real-time image of the target volume, where the target volume includes a target area and / or an organ at risk; the processing unit 402 is configured to determine the contour of the deformed target volume based on the real-time image of the target volume and the planned reference image of the target volume, and perform dose calculation based on the contour of the deformed target volume and the first dose parameter to obtain a second dose parameter that matches the deformed target volume; the first dose parameter is a dose parameter for formulating a treatment plan for the target volume in the planned reference image; the processing unit 402 is further configured to determine that the second dose parameter meets the dose evaluation requirements and indicate that adaptive radiotherapy for the target volume is not required.

[0124] In a possible implementation, the processing unit 402 is specifically configured to: perform deformation registration on the real-time image of the target volume and the planned reference image of the target volume to determine the deformation amount of the target volume; the deformation amount of the target volume is the deformation amount of the target volume in the real-time image relative to the target volume in the planned reference image; based on the deformation amount of the target volume and the planned reference image of the target volume, determine the contour of the deformed target volume.

[0125] In a possible implementation, the processing unit 402 is specifically configured to: apply the deformation amount of the target volume to the planned reference image of the target volume to determine the contour of the deformed target volume in the planned reference image; or, map the contour of the target volume in the planned reference image to the real-time image, apply the deformation amount of the target volume to the real-time image of the target volume, and determine the contour of the deformed target volume in the real-time image.

[0126] In a possible implementation, the processing unit 402 is further configured to: determine that the second dose parameter does not meet the dose evaluation requirement, and indicate that adaptive radiotherapy for the target volume is required.

[0127] In a possible implementation, the first dose parameter includes the prescribed dose of the target area before deformation and / or the first dose acceptance limit of the organ at risk before deformation, and the second dose parameter includes the dose of the target area after deformation and / or the second dose acceptance limit of the organ at risk after deformation.

[0128] In a possible implementation, the dose evaluation requirement is that the difference between the first dose parameter and the second dose parameter is within a preset threshold range.

[0129] In a possible implementation, the processing unit 402 is further configured to: obtain the contour of the target volume in the real-time image; based on the contour of the target volume, generate an adaptive radiotherapy plan.

[0130] In a possible implementation, the evaluation device 40 may further include a storage unit 403 ( Figure 4 shown in a dashed box), and the storage unit 403 stores a program or instruction. When the processing unit 402 executes the program or instruction, the evaluation device 40 can execute the evaluation method for adaptive radiotherapy described in the above method embodiments.

[0131] When implemented by hardware, the embodiments of the present application further provide an electronic device for executing the evaluation method for adaptive radiotherapy shown in the above method embodiments.

[0132] Specifically, Figure 5 is a schematic hardware structure diagram of an electronic device provided by the embodiments of the present application. As Figure 5As shown, the electronic device includes at least one processor 501, a communication line 502, and at least one communication interface 504, and may further include a memory 503. Among them, the processor 501, the memory 503, and the communication interface 504 can be connected through the communication line 502.

[0133] The processor 501 can be a central processing unit (CPU), or an application specific integrated circuit (ASIC), or one or more integrated circuits configured to implement the embodiments of the present application. For example, one or more digital signal processors (DSPs), or one or more field programmable gate arrays (FPGAs).

[0134] The communication line 502 can include a path for transmitting information between the above components.

[0135] The communication interface 504 is used to communicate with other devices or communication networks, and any transceiver-like device can be used, such as Ethernet, radio access network (RAN), wireless local area networks (WLAN), etc.

[0136] The memory 503 can be a read-only memory (ROM) or other types of static storage devices that can store static information and instructions, a random access memory (RAM) or other types of dynamic storage devices that can store information and instructions, or an electrically erasable programmable read-only memory (EEPROM), a compact disc read-only memory (CD-ROM) or other optical disc storage, optical disc storage (including compressed optical discs, laser discs, optical discs, digital versatile discs, Blu-ray discs, etc.), magnetic disk storage media or other magnetic storage devices, or any other medium that can be used to include or store desired program code in the form of instructions or data structures and can be accessed by a computer, but is not limited thereto.

[0137] In a possible design, the memory 503 can exist independently of the processor 501, that is, the memory 503 can be an external memory of the processor 501. At this time, the memory 503 can be connected to the processor 501 through the communication line 502, used to store execution instructions or application program codes, and be controlled by the processor 501 to execute, so as to implement the evaluation method of adaptive radiotherapy provided in the following embodiments of the present application. In another possible design, the memory 503 can also be integrated with the processor 501, that is, the memory 503 can be an internal memory of the processor 501. For example, the memory 503 is a cache, which can be used to temporarily store some data and instruction information, etc.

[0138] As a possible implementation manner, the processor 501 can include one or more CPUs, such as Figure 5 CPU0 and CPU1 in Figure 5 As another possible implementation manner, the electronic device can include multiple processors, such as

[0139] the processor 501 and the processor 507 in

[0140] Through the description of the above embodiments, those skilled in the art can clearly understand that for the convenience and conciseness of description, only the above division of each functional module is used as an example for illustration. In actual applications, the above functions can be allocated to different functional modules according to needs, that is, the internal structure of the device is divided into different functional modules to complete all or part of the functions described above. The specific working processes of the above-described system, device, and unit can refer to the corresponding processes in the foregoing method embodiments, and will not be elaborated herein.

[0141] The embodiments of the present application provide a computer program product containing instructions. When the computer program product runs on a computer, it causes the computer to execute the evaluation method of adaptive radiotherapy in the foregoing method embodiments.

[0142] The embodiments of the present application also provide a computer-readable storage medium. Instructions are stored in the computer-readable storage medium. When the instructions run on a computer, it causes the computer to execute the evaluation method of adaptive radiotherapy in the method flow shown in the foregoing method embodiments.

[0143] Among them, a computer-readable storage medium can be, for example, but not limited to, a system, device, or component of electricity, magnetism, light, electromagnetic, infrared, or semiconductor, or any combination of the above. More specific examples (non-exhaustive list) of the computer-readable storage medium include: an electrical connection with one or more wires, a portable computer disk, a hard disk, a random access memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM), a register, a hard disk, an optical fiber, a portable compact disc read-only memory (CD-ROM), an optical storage device, a magnetic storage device, or any suitable combination of the above, or any other form of computer-readable storage medium well-known in the art. An exemplary storage medium is coupled to the processor so that the processor can read information from the storage medium and write information to the storage medium. Of course, the storage medium can also be a component of the processor. The processor and the storage medium can be located in an application specific integrated circuit (ASIC). In the embodiments of the present application, the computer-readable storage medium can be any tangible medium that contains or stores a program, and the program can be used by or in combination with an instruction execution system, device, or component.

[0144] The various embodiments of the systems and techniques described above in this document can be implemented in digital electronic circuit systems, integrated circuit systems, field programmable gate arrays, application specific integrated circuits, application specific standard parts (ASSPs), system on chip (SOC) systems, complex programmable logic devices (CPLDs), computer hardware, firmware, software, and / or combinations thereof. These various embodiments can include: being implemented in one or more computer programs that can be executed and / or interpreted on a programmable system including at least one programmable processor, which can be a dedicated or general-purpose programmable processor, and can receive data and instructions from a storage system, at least one input device, and at least one output device, and transmit the data and instructions to the storage system, the at least one input device, and the at least one output device.

[0145] The program code for implementing the methods of the present application can be written in any combination of one or more programming languages. These program codes can be provided to the processor or controller of a general-purpose computer, a special-purpose computer, or other programmable data processing devices, such that when the program codes are executed by the processor or controller, the functions / operations specified in the flowchart and / or block diagram are implemented. The program code can be executed entirely on the machine, partially on the machine, executed partially on the machine as an independent software package and partially on a remote machine, or executed entirely on a remote machine or server.

[0146] To provide interaction with a user, the systems and techniques described herein can be implemented on a computer having: a display device for displaying information to the user, such as a cathode ray tube (CRT) or a liquid crystal display (LCD) monitor; and a keyboard and a pointing device (e.g., a mouse or a trackball) through which the user can provide input to the computer. Other kinds of devices can also be used to provide interaction with the user; for example, the feedback provided to the user can be any form of sensory feedback (e.g., visual feedback, auditory feedback, or tactile feedback); and input from the user can be received in any form (including acoustic input, voice input, or tactile input).

[0147] The systems and techniques described herein can be implemented in a computing system including backend components (e.g., as a data server), or a computing system including middleware components (e.g., an application server), or a computing system including frontend components (e.g., a user computer having a graphical user interface or a web browser through which the user can interact with an implementation of the systems and techniques described herein), or a computing system including any combination of such backend components, middleware components, or frontend components. The components of the system can be interconnected to each other by any form or medium of digital data communication (e.g., a communication network). Examples of communication networks include: local area networks, wide area networks (WANs), and the Internet.

[0148] A computer system can include a client and a server. The client and the server are generally far from each other and typically interact through a communication network. The client-server relationship is generated by computer programs running on the respective computers and having a client-server relationship with each other. The server can be a cloud server, a server of a distributed system, or a server incorporating blockchain.

[0149] Since the evaluation device, electronic device, computer-readable storage medium, and computer program product in the embodiments of the present application can be applied to the above method, the technical effects that can be obtained can also refer to the method embodiments above, and will not be elaborated herein.

[0150] In several embodiments provided by the present application, it should be understood that the disclosed systems, devices, and methods can be implemented in other ways. For example, the device embodiments described above are merely illustrative. For example, the division of the units is only a logical function division, and there may be other division methods in actual implementation. For example, multiple units or components can be combined or integrated into another system, or some features can be ignored or not executed. Another point is that the displayed or discussed couplings or direct couplings or communication connections to each other can be through some interfaces, and the indirect couplings or communication connections of devices or units can be in electrical, mechanical, or other forms.

[0151] It should be understood that various forms of the processes shown above can be used, with steps reordered, added, or deleted. For example, the steps recorded in the present disclosure can be executed in parallel, sequentially, or in different orders, as long as the desired results of the technical solutions of the present application can be achieved, and no limitations are imposed herein.

[0152] The above specific implementation manners do not constitute a limitation on the protection scope of the present application. Those skilled in the art should understand that various modifications, combinations, sub-combinations, and substitutions can be made according to design requirements and other factors. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of the present application shall be included within the protection scope of the present application.

[0153] The units described as separate components may or may not be physically separated, and the components shown as units may or may not be physical units, that is, they may be located in one place or distributed to multiple network units. Some or all of the units can be selected according to actual needs to achieve the purpose of the solution of this embodiment.

[0154] In addition, the functional units in each embodiment of the present application can be integrated in a processing unit, or each unit can exist physically separately, or two or more units can be integrated in one unit.

[0155] The above is only the specific implementation manner of the present application, but the protection scope of the present application is not limited thereto. Any changes or substitutions within the technical scope disclosed in the present application should be covered by the protection scope of the present application. Therefore, the protection scope of the present application should be subject to the protection scope of the claims.

Claims

1. An evaluation method for adaptive radiotherapy, characterized in that, The method includes: Obtaining a real-time image of a target volume, where the target volume includes a target region and / or an organ at risk; Based on the real-time image of the target volume and the planned reference image of the target volume, determining the contour of the deformed target volume, and performing dose calculation based on the contour of the deformed target volume and a first dose parameter to obtain a second dose parameter that matches the deformed target volume; the first dose parameter is a dose parameter for formulating a treatment plan for the target volume in the planned reference image; Determining that the second dose parameter meets the dose evaluation requirements, indicating that adaptive radiotherapy for the target volume is not required.

2. The method according to claim 1, characterized in that, The determining the contour of the deformed target volume based on the real-time image of the target volume and the planned reference image of the target volume includes: Performing deformation registration on the real-time image of the target volume and the planned reference image of the target volume to determine the deformation amount of the target volume; the deformation amount of the target volume is the deformation amount of the target volume in the real-time image relative to the target volume in the planned reference image; Based on the deformation amount of the target volume and the planned reference image of the target volume, determining the contour of the deformed target volume.

3. The method according to claim 2, wherein The determining the contour of the deformed target volume based on the deformation amount of the target volume and the planned reference image of the target volume includes: Applying the deformation amount of the target volume to the planned reference image of the target volume to determine the contour of the deformed target volume in the planned reference image; or, Mapping the contour of the target volume in the planned reference image to the real-time image, applying the deformation amount of the target volume to the real-time image of the target volume, and determining the contour of the deformed target volume in the real-time image.

4. The method according to claim 1, wherein The method further includes: Determining that the second dose parameter does not meet the dose evaluation requirements, indicating that adaptive radiotherapy for the target volume is required.

5. The method according to any one of claims 1-4, wherein The first dose parameter includes the prescribed dose of the target region before deformation and / or the first dose acceptance limit of the organ at risk before deformation, and the second dose parameter includes the dose of the target region after deformation and / or the second dose acceptance limit of the organ at risk after deformation.

6. The method according to any one of claims 1-4, wherein The dose evaluation requirement is that the difference between the first dose parameter and the second dose parameter is within a preset threshold range.

7. The method according to claim 4, wherein The need for adaptive radiotherapy for the target volume includes: Obtaining the contour of the target volume in the real-time image; Generating an adaptive radiotherapy plan based on the contour of the target volume.

8. An electronic device, characterized in that, The electronic device includes: a processor; A memory configured to store instructions executable by the processor; Wherein, the processor is configured to execute the instructions to implement the evaluation method of adaptive radiotherapy according to any one of claims 1-7.

9. A computer-readable storage medium, characterized in that, Instructions are stored in the computer-readable storage medium, and when the computer executes the instructions, the computer executes the evaluation method of adaptive radiotherapy according to any one of claims 1-7.

10. A computer program product, characterized in that, The computer program product includes computer instructions, and when the computer instructions run on a computer, the computer is caused to execute the evaluation method of adaptive radiotherapy according to any one of claims 1-7.

Images