Hyaluronic acid shampoo and preparation method thereof

Abstract

The invention provides hyaluronic acid shampoo and a preparation method thereof, and relates to the field of daily chemical products. The component A1 comprises the following raw materials in percentage by mass: 0.05%-0.15% of EDTA (Ethylene Diamine Tetraacetic Acid) disodium, 0.01%-0.2% of 8D hyaluronic acid, 0.2%-0.45% of polyquaternium-10, 12%-16% of a sodium laureth sulfate aqueous solution, 1%-2.5% of sodium lauryl sulfate and 0.5%-1.5% of a cocamidomethyl / glycerol mixture; a component A2: 8-12% of water, 0.1-0.3% of piroctone olamine salt, and 4-6% of a cocamidopropyl betaine / sodium chloride mixture; the component B is prepared from the following components in percentage by weight: 0.8 to 1.2 percent of sodium chloride, 0.23 percent of citric acid monohydrate and 0.8 to 1.2 percent of polyquaternium-7 / sodium benzoate mixture; the component C is prepared from the following components in percentage by weight: 0.2 to 0.4 percent of sodium benzoate, 0.3 to 0.7 percent of PPG-3 octyl ether and 0.05 to 0.15 percent of panthenol; a component D: 0.01-0.2% of a water silk / silk amino acid mixture, 0.5-0.7% of phenoxyethanol and 1-1.5% of essence; and a component E: 0.01% of water and 0.000255% of a coloring agent. Hyaluronic acid is used as a core raw material and is mixed with piroctone olamine, hydrolyzed silk and silk amino acid, so that the dandruff removing and anti-dropping effects are obviously improved.

Description

Technical Field

[0001] The present invention relates to the field of daily chemical products, and in particular to a hyaluronic acid shampoo and a preparation method thereof. Background Art

[0002] Dandruff is a natural product of the metabolism of keratinocytes on the surface of the scalp. Under normal circumstances, keratinocytes shed periodically, forming tiny flakes that are barely noticeable to the naked eye. However, when the scalp's ecological balance is disrupted, the dandruff problem becomes significantly more severe. Modern medical research shows that excessive dandruff production is closely related to the following three factors:

[0003] Microbial imbalance: The scalp is home to a diverse microbial community, among which Malassezia is widely recognized as a key cause of dandruff. This fungus breaks down sebum to produce free fatty acids, which trigger metabolic abnormalities in the scalp's stratum corneum, leading to excessive keratinocyte proliferation and the formation of large, visible flakes of dandruff.

[0004] Abnormal sebum secretion: Both excessive and insufficient sebum secretion from the sebaceous glands can cause dandruff. Excessive sebum provides a nutrient source for Malassezia fungi, accelerating their growth; insufficient sebum secretion, on the other hand, leads to dry scalp and stimulates abnormal shedding of keratinocytes.

[0005] Damage to the scalp barrier function: Physical damage (such as excessive cleaning), chemical stimulation (such as hair dye), environmental stress (such as ultraviolet rays, pollution) and other factors can destroy the scalp stratum corneum structure, reduce its moisturizing and defense capabilities, and aggravate dandruff formation.

[0006] Anti-dandruff shampoo is a product that helps to reduce dandruff and helps to reduce the amount of dandruff attached to the scalp and hair. However, the anti-dandruff products currently on the market have poor hair softness and poor long-term low-temperature stability. Summary of the Invention

[0007] The purpose of the present invention is to provide a hyaluronic acid shampoo, which uses 8 types of hyaluronic acid and piroctone olamine salt as core raw materials, and is mixed with hydrolyzed silk and silk amino acids to significantly improve the anti-dandruff and anti-hair loss effects. By controlling the mass ratio of each component, the softness of the product can be significantly improved.

[0008] Another object of the present invention is to provide a method for preparing hyaluronic acid shampoo, and the shampoo prepared by this method has excellent dandruff removal and anti-hair loss effects.

[0009] The present invention solves the technical problem by adopting the following technical solutions.

[0010] In one aspect, an embodiment of the present invention provides a hyaluronic acid shampoo comprising the following raw materials, calculated by mass percentage:

[0011] Component A1: Water as the balance, Disodium EDTA 0.05-0.15%, 8D Hyaluronic Acid 0.01-0.2%, Polyquaternium-10 0.2-0.45%, Sodium Laureth Sulfate Aqueous Solution 12-16%, Sodium Lauryl Sulfate 1-2.5%, Cocamidomethyl / Glycerin Mixture 0.5-1.5%;

[0012] Component A2: Water 8-12%, Piroctone Olamine Salt 0.1-0.3%, Cocamidopropyl Betaine / Sodium Chloride Mixture 4-6%;

[0013] Component B: sodium chloride 0.8-1.2%, citric acid monohydrate 0.23%, polyquaternium-7 / sodium benzoate mixture 0.8-1.2%;

[0014] Component C: Sodium Benzoate 0.2-0.4%, PPG-3 Octyl Ether 0.3-0.7%, Panthenol 0.05-0.15%;

[0015] Component D: water silk / silk amino acid mixture 0.01-0.2%, phenoxyethanol 0.5-0.7%, fragrance 1-1.5%;

[0016] Component E: water 0.01, colorant 0.000255%.

[0017] In some embodiments of the present invention, the 8D hyaluronic acid comprises, by mass fraction, 3% 1,2-hexanediol, 1.3% xanthan gum, 0.5% caprylyl glycol, 0.1% butylene glycol, 0.04% glucose, 0.02% sodium hyaluronate, 0.01% chondrus crispus extract, 0.002% hydroxypropyltrimonium chloride hyaluronic acid, 0.0002% hydrolyzed hyaluronic acid, 0.0002% acetylated sodium hyaluronate, 0.00005% hyaluronic acid, 0.00002% sodium hyaluronate cross-polymer, 0.00002% hydrolyzed sodium hyaluronate, 0.00001% potassium hyaluronate, and the balance is water.

[0018] In some embodiments of the present invention, the cocamide methyl / glycerol mixture comprises, by mass percentage, 90% cocamide methyl and 10% glycerol.

[0019] In some embodiments of the present invention, the cocamidopropyl betaine / sodium chloride mixture comprises, by mass percentage, 29.5% cocamidopropyl betaine, 4.5% sodium chloride, 65.5% water, and 0.5% sodium benzoate.

[0020] In some embodiments of the present invention, the polyquaternium-7 / sodium benzoate mixture comprises, by mass fraction, 89.9% water, 79.5% polyquaternium-7, and 0.6% sodium benzoate.

[0021] In some embodiments of the present invention, the water silk / silk amino acid mixture comprises, by mass fraction, 94% water, 3% hydrolyzed silk, 2% silk amino acids, 0.85% glycerol, 0.1% 1,2-hexanediol, and 0.05% lauroyl arginine ethyl ester hydrochloride.

[0022] On the other hand, an embodiment of the present invention provides a method for preparing hyaluronic acid shampoo, comprising the following steps:

[0023] S1, add component A1 into a stirring pot, homogenize and disperse evenly, heat to 82-85℃, and homogenize for 3-5 minutes;

[0024] S2, after defoaming at 82-85℃ for 30-40min, add component B and cool to 50-55℃;

[0025] S3, add component A2 and component C, homogenize for 2-5 minutes, and continue to cool to 40-45℃;

[0026] S4, add component D and component E and stir evenly;

[0027] S5, lowering the temperature to 35-38°C, and discharging the material to obtain the hyaluronic acid shampoo.

[0028] In some embodiments of the present invention, in step S1, the speed of homogenizing and stirring is 1000 rpm / min, and in step S3, the speed of homogenizing and stirring is 800 rpm / min.

[0029] Compared with the prior art, the embodiments of the present invention have at least the following advantages or beneficial effects:

[0030] The hyaluronic acid shampoo provided by the present invention uses eight types of hyaluronic acid as core raw materials, and synergistically enhances the dandruff removal and hair loss prevention effects of the shampoo with piroctone ethanolamine salt, hydrolyzed silk and silk amino acids. In addition, by controlling the specific components and mass ratio of the conditioner, the softness of the hair after use can be significantly improved. The shampoo has the advantage of good long-term low-temperature stability.

[0031] The preparation method provided by the present invention adds the components in batches to a stirring pot for homogenization according to their properties. High-speed homogenization is first performed at high temperature to ensure that the raw materials are fully mixed. As the temperature decreases, the remaining raw materials that are not resistant to high temperatures are added and stirred at low speed for uniformity. This effectively protects the active ingredients of the raw materials from decomposition and improves the utilization rate of the active ingredients of the raw materials. The shampoo prepared by this method has a high utilization rate of the active ingredients of the raw materials and has excellent anti-dandruff and anti-hair loss effects. BRIEF DESCRIPTION OF THE DRAWINGS

[0032] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the following briefly introduces the drawings required for use in the embodiments. It should be understood that the following drawings only illustrate certain embodiments of the present invention and therefore should not be regarded as limiting the scope. For ordinary technicians in this field, other relevant drawings can be obtained based on these drawings without paying any creative work.

[0033] Figure 1 The figure is a schematic diagram of the process of preparing shampoo according to an embodiment of the present invention. DETAILED DESCRIPTION

[0034] To make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention are described clearly and completely below. Where specific conditions are not specified in the embodiments, conventional conditions or conditions recommended by the manufacturer are used. Where the manufacturer of the reagents or instruments is not specified, all are conventional products that can be purchased commercially.

[0035] It should be noted that, in the absence of conflict, the embodiments and features of the embodiments of the present invention can be combined with each other. The present invention will be described in detail below with reference to specific embodiments.

[0036] The embodiment of the present invention provides a hyaluronic acid shampoo, comprising the following raw materials, calculated by mass percentage, component A1: water as the balance, 0.05-0.15% disodium EDTA, 0.01-0.2% 8D hyaluronic acid, 0.2-0.45% polyquaternium-10, 12-16% sodium laureth sulfate aqueous solution, 1-2.5% sodium lauryl sulfate, and 0.5-1.5% cocamide methyl / glycerin mixture;

[0037] Component A2: Water 8-12%, Piroctone Olamine Salt 0.1-0.3%, Cocamidopropyl Betaine / Sodium Chloride Mixture 4-6%;

[0038] Component B: sodium chloride 0.8-1.2%, citric acid monohydrate 0.23%, polyquaternium-7 / sodium benzoate mixture 0.8-1.2%;

[0039] Component C: Sodium Benzoate 0.2-0.4%, PPG-3 Octyl Ether 0.3-0.7%, Panthenol 0.05-0.15%;

[0040] Component D: water silk / silk amino acid mixture 0.01-0.2%, phenoxyethanol 0.5-0.7%, fragrance 1-1.5%;

[0041] Component E: water 0.01, colorant 0.000255%.

[0042] Among them, 8D hyaluronic acid includes, by mass fraction: 1,2-hexanediol 3%, xanthan gum 1.3%, caprylyl glycol 0.5%, butylene glycol 0.1%, glucose 0.04%, sodium hyaluronate 0.02%, Chondrus crispus extract 0.01%, hydroxypropyltrimonium chloride hyaluronic acid 0.002%, hydrolyzed hyaluronic acid 0.0002%, acetylated sodium hyaluronate 0.0002%, hyaluronic acid 0.00005%, sodium hyaluronate crosspolymer 0.00002%, hydrolyzed sodium hyaluronate 0.00002%, potassium hyaluronate 0.00001%, and the balance is water.

[0043] Chondrus Crispus Extract is an active ingredient extracted from the natural seaweed Chondrus Crispus, which contains polysaccharides and various bioactive components. Preferably, in the embodiment of the present invention, 8D hyaluronic acid is a mixed raw material that can be purchased directly from the market. Its manufacturer is INTERCARE Co., Ltd.

[0044] The cocamide methyl / glycerol mixture comprises, by mass percentage, 90% cocamide methyl and 10% glycerol.

[0045] The cocamidopropyl betaine / sodium chloride mixture comprises, by mass percentage, 29.5% cocamidopropyl betaine, 4.5% sodium chloride, 65.5% water, and 0.5% sodium benzoate.

[0046] The polyquaternium-7 / sodium benzoate mixture comprises, by mass fraction, 89.9% water, 79.5% polyquaternium-7, and 0.6% sodium benzoate.

[0047] The water silk / silk amino acid mixture comprises, by mass, 94% water, 3% hydrolyzed silk, 2% silk amino acids, 0.85% glycerol, 0.1% 1,2-hexanediol, and 0.05% lauroyl arginine ethyl ester hydrochloride. Hydrolyzed silk is a product produced by hydrolyzing silk protein into small peptides. The hydrolyzed silk used in this embodiment is produced by Guangdong Simei Fanghua Biotechnology Co., Ltd. Silk amino acids are a type of mixed amino acids extracted from silk. The silk amino acids used in this embodiment are produced by Shaanxi Tianzhicheng Biotechnology Co., Ltd.

[0048] A method for preparing hyaluronic acid shampoo, comprising the following steps:

[0049] S1, add component A1 into a stirring pot, homogenize and disperse evenly at a speed of 1000 rpm / min, heat to 82-85℃, and homogenize for 3-5 minutes;

[0050] S2, after defoaming at 82-85℃ for 30-40min, add component B and cool to 50-55℃;

[0051] S3, add component A2 and component C, homogenize at low speed (800 rpm / min) for 2-5 minutes, and continue to cool to 40-45°C;

[0052] S4, add component D and component E and stir evenly;

[0053] S5, lowering the temperature to 35-38°C, and discharging the material to obtain the hyaluronic acid shampoo.

[0054] The features and performance of the present invention are further described in detail below with reference to the embodiments.

[0055] Examples 1-3

[0056] According to the ratio in Table 1, the raw materials of each group of shampoo were prepared. It should be noted that the raw materials in Table 1 were purchased directly from the market.

[0057] Table 1 Raw material ratio of each shampoo

[0058]

[0059]

[0060] The shampoos of Examples 1-3 and Comparative Examples 1-3 were prepared as follows:

[0061] S1, add component A1 into a stirring pot, homogenize and disperse evenly at a speed of 1000 rpm / min, heat to 85±1℃, and homogenize for 3 minutes;

[0062] S2, after defoaming at 85±1℃ for 30min, add component B and cool to 55±1℃;

[0063] S3, add component A2 and component C, homogenize at low speed (800 rpm / min) for 2 minutes, and continue to cool to 40±1℃;

[0064] S4, add component D and component E and stir evenly;

[0065] S5, lowering the temperature to 35±1°C and discharging the material to obtain the hyaluronic acid shampoo.

[0066] Experimental example

[0067] 1. Using Malassezia as an indicator bacteria, the diameter of the Malassezia inhibition ring of the test sample group and the blank control group was measured. If the inhibition ring of the test sample group was superior (larger) than that of the blank control group, and the inhibition ring diameter was ≥10 mm, the test sample was considered to have an anti-dandruff effect. The results are shown in Table 2.

[0068] Table 2

[0069]

[0070] From Table 2, can draw, the shampoo of embodiment 1-3, its antibacterial effect for Malassezia is better than comparison 1-3, namely the shampoo of embodiment 1-3 has certain antibacterial property, can suppress the dandruff caused by Malassezia, has anti-dandruff effect.In comparative example 1 and comparative example 2, piroctone olamine salt is not added, and its antibacterial property is all relatively poor.Compared to comparative example 2, the hyaluronic acid added in comparative example 1 is 0.01%, and the hyaluronic acid added in comparative example 2 is 0.1%, but the antibacterial property of comparative example 2 improves, in comparative example 3, hyaluronic acid is not added, and antibacterial property is worse than comparative example 1, can illustrate, piroctone olamine salt and 8D hyaluronic acid have the effect of synergistic enhancement, can act in conjunction, improve the antibacterial property of shampoo.And compared to embodiment 1-3, piroctone olamine salt, 8D hyaluronic acid also synergize with all the other raw materials, improve the antibacterial property of shampoo.

[0071] 2. 90 volunteers diagnosed with seborrheic alopecia in an outpatient clinic, aged 25 to 40 years, were randomly divided into 6 groups, each with 15 participants. Each group used the shampoo prepared in Examples 1 to 3 and Comparative Examples 1 to 3, respectively, and washed their hair once every other day, massaging their scalp with the shampoo for at least 3 minutes during washing. This was continued for 12 weeks. After 12 weeks, dandruff and itching were evaluated using a 1 to 10-point scale, with 1 indicating complete ineffectiveness and 10 indicating complete effectiveness. The evaluation results are shown in Table 3.

[0072] Table 3 Examples 1-3 and Comparative Examples 1-3 Shampoo Scores (Average Value)

[0073] Group Dandruff improvement Improvement of itchy scalp Combability Example 1 8.2 7.8 8.2 Example 2 8.4 8.1 8.3 Example 3 8.8 8.7 8.3 Comparative Example 1 6.8 6.5 7.5 Comparative Example 2 7.5 7.6 8.1 Comparative Example 3 6.6 6.3 7.2

[0074] From Table 3, can draw, the shampoo of embodiment 1-3 has excellent anti-dandruff, antipruritic effect for seborrheic alopecia, and hair is more compliant after use.In comparative example 1, piroctone olamine salt is not added, and its antibacterial property is the poorest, and shows as dandruff, itchy head and poor improvement effect.In comparative example 2, the content of hyaluronic acid increases 10 times, and the anti-dandruff, antipruritic and compliance of this shampoo all improve to some extent, and in comparative example 3, for adding hyaluronic acid, correspondingly, anti-dandruff, antipruritic and compliance all have decline.Can illustrate, piroctone olamine salt and 8D hyaluronic acid synergistic synergy improve the anti-dandruff and antipruritic effect of shampoo, and act in conjunction with all the other raw materials, improve the anti-dandruff and antipruritic, compliant effect of shampoo.

[0075] In summary, the hyaluronic acid shampoo provided by the embodiment of the present invention uses 8 types of hyaluronic acid as core raw materials, and synergizes with piroctone ethanolamine salt, hydrolyzed silk and silk amino acids to significantly improve the anti-dandruff and anti-hair loss effects of the shampoo. By controlling the specific components and mass ratio of the conditioner, the softness of the hair after use can be significantly improved. The shampoo has the advantage of good long-term low-temperature stability.

[0076] The embodiments described above are some, but not all, of the embodiments of the present invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but rather merely represents selected embodiments of the present invention. All other embodiments derived by persons of ordinary skill in the art based on the embodiments of the present invention without inventive effort are also within the scope of protection of the present invention.

Claims

1. A hyaluronic acid shampoo, characterized in that: Calculated by mass percentage, including the following raw materials, Component A1: Water as the balance, Disodium EDTA 0.05-0.15%, 8D Hyaluronic Acid 0.01-0.2%, Polyquaternium-10 0.2-0.45%, Sodium Laureth Sulfate Aqueous Solution 12-16%, Sodium Lauryl Sulfate 1-2.5%, Cocamidomethyl / Glycerin Mixture 0.5-1.5%; Component A2: Water 8-12%, Piroctone Olamine Salt 0.1-0.3%, Cocamidopropyl Betaine / Sodium Chloride Mixture 4-6%; Component B: sodium chloride 0.8-1.2%, citric acid monohydrate 0.23%, polyquaternium-7 / sodium benzoate mixture 0.8-1.2%; Component C: Sodium Benzoate 0.2-0.4%, PPG-3 Octyl Ether 0.3-0.7%, Panthenol 0.05-0.15%; Component D: water silk / silk amino acid mixture 0.01-0.2%, phenoxyethanol 0.5-0.7%, fragrance 1-1.5%; Component E: water 0.01, colorant 0.000255%.

2. The hyaluronic acid shampoo according to claim 1, characterized in that The 8D hyaluronic acid comprises, by mass fraction, 3% 1,2-hexanediol, 1.3% xanthan gum, 0.5% caprylyl glycol, 0.1% butylene glycol, 0.04% glucose, 0.02% sodium hyaluronate, 0.01% Chondrus crispus extract, 0.002% hydroxypropyltrimonium chloride hyaluronic acid, 0.0002% hydrolyzed hyaluronic acid, 0.0002% acetylated sodium hyaluronate, 0.00005% hyaluronic acid, 0.00002% sodium hyaluronate crosspolymer, 0.00002% hydrolyzed sodium hyaluronate, 0.00001% potassium hyaluronate, and the balance is water.

3. The hyaluronic acid shampoo according to claim 1, characterized in that The cocamide methyl / glycerol mixture comprises, by mass percentage, 90% cocamide methyl and 10% glycerol.

4. The hyaluronic acid shampoo according to claim 1, characterized in that The cocamidopropyl betaine / sodium chloride mixture comprises, by mass percentage, 29.5% cocamidopropyl betaine, 4.5% sodium chloride, 65.5% water, and 0.5% sodium benzoate.

5. The hyaluronic acid shampoo according to claim 1, characterized in that The polyquaternium-7 / sodium benzoate mixture comprises, by mass fraction, 89.9% water, 79.5% polyquaternium-7, and 0.6% sodium benzoate.

6. The hyaluronic acid shampoo according to claim 1, characterized in that The water silk / silk amino acid mixture comprises, by mass fraction, 94% water, 3% hydrolyzed silk, 2% silk amino acids, 0.85% glycerol, 0.1% 1,2-hexanediol, and 0.05% lauroyl arginine ethyl ester hydrochloride.

7. A method for preparing the hyaluronic acid shampoo according to any one of claims 1 to 6, characterized in that: The following steps are involved: S1, add component A1 into a stirring pot, homogenize and disperse evenly, heat to 82-85℃, and homogenize for 3-5 minutes; S2, after defoaming at 82-85℃ for 30-40min, add component B and cool to 50-55℃; S3, add component A2 and component C, homogenize for 2-5 minutes, and continue to cool to 40-45℃; S4, add component D and component E and stir evenly; S5, lowering the temperature to 35-38°C, and discharging the material to obtain the hyaluronic acid shampoo.

8. The method for preparing hyaluronic acid shampoo according to claim 7, characterized in that: In the step S1, the speed of homogenizing and stirring is 1000 rpm / min, and in the step S3, the speed of homogenizing and stirring is 800 rpm / min.

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