Emodin monomethyl ether suspending agent and preparation method thereof

Abstract

The invention relates to the field of biological agriculture, and particularly discloses an emodin monomethyl ether suspending agent and a preparation method of the emodin monomethyl ether suspending agent. The suspending agent is prepared from the following raw materials in parts by weight: 2.8 to 3.2 parts of a physcion composite material, 1 to 1.5 parts of a dispersing agent, 0.5 to 1 part of a stabilizing agent, 1 to 2 parts of a wetting agent, 0.5 to 1 part of a defoaming agent, 350 to 400 parts of water, 0.5 to 1 part of high-fat pectin particles and 0.2 to 0.5 part of a nano whisker mixture, the preparation method comprises the following steps: S1, weighing the physcion composite material, the dispersing agent, the high-fat pectin particles and the water, and uniformly mixing and stirring to obtain a primary mixture; s2, adding a stabilizer, a wetting agent, a defoaming agent and a nano-whisker mixture into the primary mixture, and continuously mixing and uniformly stirring to obtain a suspending agent; meanwhile, the composition has the advantages of good stability and high active ingredient activity, thereby ensuring healthy growth of crops and improving the quality of agricultural products.

Description

Technical Field

[0001] The present application relates to the field of biological agriculture, and more specifically, to a physcion methyl ether suspension concentrate and a preparation method thereof. Background Art

[0002] At present, as the concept of sustainable agricultural development has become more and more popular, botanical pesticides have received more and more attention due to their eco-friendliness. Among them, rhubarb rhizomes are a traditional Chinese medicinal material, and the physcion methyl ether extract of rhubarb rhizomes has been found to have good bioactive substances in agricultural production. It can effectively enhance the stress resistance of crops and reduce the occurrence of diseases. However, how to stably apply its active ingredients to crop spraying has always been a difficulty.

[0003] Currently, physcion preparations on the market generally have problems such as poor stability, poor dispersibility, and slow release of efficacy, which directly affect their application effect in actual farmland.

[0004] In the existing technology, most physcion preparations are in the form of emulsifiable concentrates, but they are prone to precipitation during storage and easy to cause drug liquid separation when diluted for use, resulting in unstable efficacy. In addition, due to the lack of effective synergistic ingredients, the biological activity of physcion cannot be fully demonstrated, limiting its promotion and use in modern agricultural production.

[0005] Therefore, how to prepare a new suspension concentrate that has the advantages of good stability and high activity of effective ingredients, so as to ensure the healthy growth of crops and improve the quality of agricultural products, is a problem to be solved. Summary of the Invention

[0006] In order to prepare a new physcion methyl ether suspension concentrate that has the advantages of good stability and high activity of effective ingredients, thereby ensuring the healthy growth of crops and improving the quality of agricultural products, the present application provides a physcion methyl ether suspension concentrate and a preparation method thereof.

[0007] In the first aspect, the present application provides a physcion methyl ether suspension concentrate, which adopts the following technical solution: A physcion methyl ether suspension comprises the following raw materials in parts by weight: 2.8-3.2 parts of physcion methyl ether compound, 1-1.5 parts of dispersant, 0.5-1 part of stabilizer, 1-2 parts of wetting agent, 0.5-1 part of defoamer, 350-400 parts of water, 0.5-1 part of high-fat pectin particles, and 0.2-0.5 part of nano whisker mixture.

[0008] By adopting the above technical solution, the physcion methyl ether composite material has a good dispersion and suspension effect under the action of the dispersant and the stabilizer; when the suspending agent is sprayed onto the surface of crop leaves, the whiskers in the nano whisker mixture have a piercing effect and act on the surface of the crop leaves, thereby improving the contact and adhesion effect between the crop leaf surface and the physcion methyl ether composite material in the suspending agent; the wetting agent and high-fat pectin particles are combined, the hydrophilic effect of the high-fat pectin particles is combined, and the hydroxyl groups in the physcion methyl ether are combined to facilitate the adsorption of physcion methyl ether by the high-fat pectin particles; the stable dispersion effect and adhesion effect of the high-fat pectin particles are combined, and the long-lasting wetting effect of the wetting agent is combined, so that the physcion methyl ether is stably attached to the surface of the crop leaves and exerts its effect for a long time, thereby improving the stability and effective biological activity of the physcion methyl ether on the surface of the crop leaves, preventing and controlling powdery mildew and viral diseases of the crops, thereby ensuring the healthy growth of the crops and improving the quality of agricultural products.

[0009] Preferably, the physcion composite material is composed of physcion and sustained-release physcion particles in a mass ratio of 1:0.2-0.5.

[0010] By adopting the above technical solution, a higher content of physcion is combined with a portion of slow-release physcion microparticles, and the directly dispersed physcion acts on the surface of crops to quickly exert its effect. The slow-release physcion microparticles can exert their effect on the surface of crop leaves for a long time, thereby extending the biological activity and stability of physcion on the surface of crop leaves.

[0011] Preferably, the sustained-release physcion microparticles are prepared from cellulose acetate microspheres, fucoidan solution, and physcion microparticles in a mass ratio of 1:0.2-0.3:0.2-0.4.

[0012] By adopting the above technical solution, the porous loading effect of cellulose acetate microspheres is utilized to facilitate the attachment of physcion methyl ether, and the bonding effect of fucoidan liquid is combined to further improve the attachment stability of physcion methyl ether on the surface of cellulose acetate microspheres; fucoidan has good hydrophilic stability, and combined with the hydrophilic but water-insoluble characteristics of cellulose acetate, the sustained-release physcion methyl ether microparticles are stably dispersed in the suspension and have a good adhesion effect on the surface of crop leaves; after the sustained-release physcion methyl ether microspheres are attached to the surface of crop leaves, the moisture absorption effect of fucoidan and cellulose acetate is utilized to further improve the long-term adhesion of the physcion methyl ether microspheres to the surface of the crop leaves, thereby improving the stability and biological activity of the suspension on the surface of the crop leaves.

[0013] Preferably, the fucoidan solution is prepared by mixing a fucoidan solution and sodium N-lauroyl sarcosinate in a mass ratio of 100:1-2.

[0014] By adopting the above technical solution, the fucoidan solution and sodium N-lauroyl sarcosinate are mixed, so that the viscosity of the fucoidan solution will not be too high to affect the spraying effect of the suspension on the surface of the crop leaves, and the fucoidan solution can be ensured to adhere to the surface of the crop leaves; the penetration and spreading effect of sodium N-lauroyl sarcosinate on the surface of the crop leaves is utilized to increase the contact area between physcion and the surface of the crop leaves, and the hygroscopic and adhesive effect of the fucoidan solution is combined to ensure that the physcion compound adheres to the crop leaves, thereby improving the stability and biological activity of physcion on the surface of the crop leaves.

[0015] Preferably, the high-fat pectin particles are prepared by cooling a high-fat pectin solution at 80-85°C to 30-32°C, breaking it up, and freeze-drying it; the high-fat pectin solution is prepared from high-fat pectin, white sugar, and 80-85°C water in a mass ratio of 1:3-4:100-120.

[0016] By adopting the above technical scheme, a high-fat pectin solution is prepared under the conditions of high-temperature water and white sugar. The high-fat pectin solution has good fluidity at 80-85°C. After cooling to about 30°C, the viscosity gradually increases to form a gel-like body. After being dispersed and freeze-dried, high-fat pectin particles with a porous structure are obtained. The attraction effect between the hydroxyl groups in the high-fat pectin particles and the hydroxyl groups in physcion methyl ether is combined with the porous adsorption effect of the high-fat pectin particles to further attract the physcion methyl ether in the suspending agent to adhere to the surface of the high-fat pectin particles. The hydrophilic stability of the high-fat pectin particles is utilized to further improve the dispersion stability of the physcion methyl ether in the suspending agent.

[0017] After the suspension is sprayed onto the surface of crop leaves, the glucose in the high-fat pectin microparticles, the fucoidan in the slow-release physcion microparticles, and sodium N-lauroylsarcosine regulate the penetration effect on the crop leaf surface, thereby further promoting the adhesion of physcion and the slow-release physcion microparticles to the crop leaf surface; the hygroscopic effect of the high-fat pectin microparticles and cellulose acetate microspheres facilitates the adsorption of moisture in the external environment, forming a connecting composite film on the crop leaf surface, protecting the attachment of physcion to the crop leaf surface, and improving wettability, thereby ensuring that the suspension exerts its effect on the crop leaf surface for a long time, and making physcion have long-term stability and biological activity on the crop leaf surface, thereby ensuring crop growth and increasing crop yield.

[0018] Preferably, the nano whisker mixture consists of tetrapod-shaped zinc oxide whiskers and hydroxyapatite whiskers in a mass ratio of 1:0.5-1.

[0019] By adopting the above technical solution, the four-needle zinc oxide whiskers have a four-needle thorn structure, which is combined with the needle-like structure of the hydroxyapatite whiskers. When the nano whisker mixture is sprayed onto the surface of crop leaves, the four-needle whiskers combined with the needle-like whiskers have a scratching effect on the surface of the crop leaves, thereby increasing the contact area between the crop leaves and the physcion methyl ether complex, thereby improving the adhesion stability and biological activity of the physcion methyl ether complex on the surface of the crop leaves.

[0020] Tetrapod-shaped zinc oxide whiskers and hydroxyapatite whiskers have certain antibacterial effects, which can inhibit the growth and reproduction of pathogens and improve the health of crops. Zinc oxide itself is a trace element fertilizer that can further promote crop growth. Tetrapod-shaped zinc oxide whiskers use their four-needle structure to improve the utilization rate of zinc by crops, thereby further promoting the growth and development of crops. Combined with the phosphorus element in hydroxyapatite whiskers, they enrich the important nutrients required for crop growth, further ensuring crop health and increasing crop yields.

[0021] Preferably, the dispersant is composed of sodium lignin sulfonate and sucrose fatty acid ester in a mass ratio of 1:1-2.

[0022] By adopting the above technical solution, the hydroxyl groups in the sodium lignin sulfonate and the sucrose fatty acid ester can be attracted and connected with the hydroxyl groups in the physcion methyl ether compound, and the dispersing effects of the sodium lignin sulfonate and the sucrose fatty acid ester are combined to make the physcion methyl ether compound uniformly dispersed in the suspending agent. When the suspending agent is sprayed onto the surface of crop leaves, the sodium lignin sulfonate and the sucrose fatty acid ester are used to reduce the surface tension of the suspending agent on the crop leaves, making it easier for the suspending agent to spread evenly and adhere to the leaf surface, thereby helping the physcion methyl ether compound to penetrate and wet the crop leaf surface, thereby improving the adhesion stability and active utilization rate of the suspending agent.

[0023] Preferably, the stabilizer consists of sodium carboxymethyl cellulose and sodium alginate in a mass ratio of 1:0.5-1.

[0024] By adopting the above technical solution, sodium carboxymethyl cellulose and sodium alginate are combined to achieve a good thickening and suspending effect, thereby improving the stability of the suspending agent, so that the physcion methyl ether compound in the suspending agent is stably attached to the surface of crop leaves. In addition, the sodium alginate, the physcion methyl ether compound, the high-fat pectin particles and the stabilizer can further improve the film-forming effect, forming a thin film on the surface of the crop leaves, thereby protecting the suspending agent from being stably attached to the surface of the crop leaves, and also ensuring the biological activity of the physcion methyl ether mixture, prolonging the efficacy time, and promoting the growth and development of crops.

[0025] Preferably, the wetting agent consists of castor oil polyoxyethylene ether and glycerol in a mass ratio of 1:0.1-0.4.

[0026] By adopting the above technical solution, castor oil polyoxyethylene ether and glycerol have good hydrophilic wettability, ensuring that the suspending agent forms a thin film on the surface of crop leaves, so that the suspending agent can be stably attached to the surface of crop leaves and exert its medicinal effect for a long time.

[0027] In a second aspect, the present application provides a method for preparing a physcion suspension concentrate, which adopts the following technical solution: a method for preparing a physcion suspension concentrate, comprising the following steps: S1. Weigh the physcion methyl ether compound, dispersant, high-fat pectin particles, and water, mix and stir evenly to obtain a primary mixture; S2. Add stabilizer, wetting agent, defoamer and nano whisker mixture to the primary mixture, continue mixing and stirring to obtain a suspension.

[0028] By adopting the above technical solution, the prepared suspension concentrate has good dispersion effect and stability during storage, is not prone to precipitation problems, and has good adhesion stability after being sprayed onto the surface of crop leaves. It can also ensure that the physcion methyl ether compound has high biological activity, so that the physcion methyl ether in the suspension concentrate can exert its effect for a long time, inhibit powdery mildew and viral diseases, and ensure the growth and development of crops.

[0029] In summary, this application has the following beneficial effects: 1. The physcion methyl ether compound has a good dispersion and suspension effect under the action of dispersants and stabilizers. When the suspension agent is sprayed onto the surface of crop leaves, the whiskers in the nano whisker mixture penetrate into the surface of the crop leaves, thereby improving the contact and adhesion effect between the crop leaf surface and the physcion methyl ether compound in the suspension agent. The wetting agent and high-fat pectin particles are combined with the hydrophilic effect of the high-fat pectin particles and the hydroxyl groups in the physcion methyl ether to facilitate the adsorption of physcion methyl ether by the high-fat pectin particles. The stable dispersion and adhesion effects of the high-fat pectin particles, combined with the long-lasting wetting effect of the wetting agent, facilitate the stable attachment of physcion methyl ether to the surface of the crop leaves and its long-lasting effect, thereby improving the stability and effective biological activity of physcion methyl ether on the surface of the crop leaves, preventing and controlling powdery mildew and viral diseases of the crops, thereby ensuring the healthy growth of crops and improving the quality of agricultural products.

[0030] 2. The porous loading effect of cellulose acetate microspheres is utilized to facilitate the attachment of physcion, and the bonding effect of fucoidan solution is combined to further improve the attachment stability of physcion on the surface of cellulose acetate microspheres. Fucoidan has good hydrophilic stability, and combined with the hydrophilic but water-insoluble characteristics of cellulose acetate, the sustained-release physcion particles are stably dispersed in the suspension and have good adhesion effect on the surface of crop leaves. After the sustained-release physcion microspheres are attached to the surface of crop leaves, the moisture absorption effect of fucoidan and cellulose acetate is utilized to further improve the long-term adhesion of physcion microspheres on the surface of crop leaves, thereby improving the stability and biological activity of the suspension on the surface of crop leaves.

[0031] 3. There is a wax layer on the surface of some crop leaves. The water-based suspension concentrate has poor adhesion to the wax layer on the surface of crop leaves. By utilizing the emulsification effect of nano whisker mixture, sodium N-lauroyl sarcosine, sucrose fatty acid ester, and castor oil polyoxyethylene ether on the fatty acids in the wax layer, the wax layer on the surface of crop leaves is treated, and the adhesion effect of physcion methyl ether to the surface of crop leaves is increased, thereby improving the adhesion stability and biological activity of the suspension concentrate on the surface of crop leaves and broadening the scope of use of the suspension concentrate. DETAILED DESCRIPTION

[0032] The present application is further described in detail below with reference to the embodiments.

[0033] Preparation Example of Sustained-Release Physcion Microparticles Among the following raw materials, sodium N-lauroyl sarcosinate was purchased from Shandong Guohua Chemical Co., Ltd.; fucoidan was purchased from Fufeng Sinuote Biotechnology Co., Ltd., 20%; other raw materials were commonly available on the market.

[0034] Preparation Example 1: Sustained-release physcion methyl ether microparticles were prepared by the following method: 1 kg of cellulose acetate microparticles having an average particle size of 5 μm, an average open porosity of 75%, and an average pore diameter of 300 nm were placed in 10 kg of water; 1 kg of physcion methyl ether having an average particle size of 80 nm was then added, and ultrasonic dispersion was performed at 20 kHz for 20 minutes. The cellulose acetate microparticles were then filtered out, freeze-dried, and dispersed to obtain cellulose acetate microspheres having an average particle size of 5-10 μm. 100 kg of fucoidan solution and 1 kg of sodium N-lauroyl sarcosinate were mixed and stirred uniformly to obtain a fucoidan solution; the fucoidan solution was a fucoidan aqueous solution with a mass fraction of 1%; 0.25 kg of fucoidan liquid was evenly sprayed on the surface of cellulose acetate microspheres, and then 0.3 kg of physcion microparticles were added. The average particle size of the physcion microparticles was 1 μm. After drying and dispersion, the finished product of sustained-release physcion microparticles was obtained. The average particle size of the sustained-release physcion microparticles was 10-20 μm.

[0035] Preparation Example 2: This preparation example differs from Preparation Example 1 in that: 100 kg of fucoidan solution and 1 kg of sodium N-lauroyl sarcosinate were mixed and stirred uniformly to obtain a fucoidan solution; the fucoidan solution was a fucoidan aqueous solution with a mass fraction of 1%; 0.2 kg of fucoidan liquid was evenly sprayed on the surface of cellulose acetate microspheres, and then 0.2 kg of physcion microparticles were added, the average particle size of the physcion microparticles was 1 μm, and after drying and dispersion, the finished product of sustained-release physcion microparticles was obtained, and the average particle size of the sustained-release physcion microparticles was 10-20 μm.

[0036] Preparation Example 3: This preparation example differs from Preparation Example 1 in that: 100 kg of fucoidan solution and 2 kg of sodium N-lauroyl sarcosinate were mixed and stirred uniformly to obtain a fucoidan solution; the fucoidan solution was a fucoidan aqueous solution with a mass fraction of 1%; 0.3 kg of fucoidan liquid was evenly sprayed on the surface of cellulose acetate microspheres, and then 0.4 kg of physcion microparticles were added, the average particle size of the physcion microparticles was 1 μm, and after drying and dispersion, the finished product of sustained-release physcion microparticles was obtained, the average particle size of the sustained-release physcion microparticles was 10-20 μm.

[0037] Preparation example of high-fat pectin microparticles Among the following raw materials, high-fat pectin was purchased from Shandong Huiheng Biotechnology Co., Ltd.; other raw materials were commercially available.

[0038] Preparation Example 4: High-fat pectin microparticles were prepared by the following method: 1 kg of high-fat pectin, 3.5 kg of white sugar and 110 kg of 85°C water were mixed and stirred until the high-fat pectin was completely dissolved to obtain a high-fat pectin solution; The high-fat pectin solution was cooled to 32° C., then broken up by a blender, freeze-dried, and finally crushed to obtain finished high-fat pectin microparticles. The average particle size of the high-fat pectin microparticles was 5 μm.

[0039] Preparation Example 5: This preparation example differs from Preparation Example 4 in that: 1 kg of high-fat pectin, 3 kg of white sugar and 100 kg of 80°C water were mixed and stirred until the high-fat pectin was completely dissolved to obtain a high-fat pectin solution; The high-fat pectin solution was cooled to 30° C., then broken up by a blender, freeze-dried, and finally crushed to obtain finished high-fat pectin microparticles. The average particle size of the high-fat pectin microparticles was 5 μm.

[0040] Preparation Example 6: This preparation example differs from Preparation Example 4 in that: 1 kg of high-fat pectin, 4 kg of white sugar and 120 kg of 85°C water were mixed and stirred until the high-fat pectin was completely dissolved to obtain a high-fat pectin solution; The high-fat pectin solution was cooled to 32° C., then broken up by a blender, freeze-dried, and finally crushed to obtain finished high-fat pectin microparticles. The average particle size of the high-fat pectin microparticles was 5 μm. Example

[0041] The following raw materials are all commercially available.

[0042] Example 1: A physcion methyl ether suspension: Physcion methyl ether composite material 3kg, dispersant 1.2kg, stabilizer 0.8kg, wetting agent 1.5kg, defoamer 0.8kg, water 380kg, high-fat pectin particles 0.8kg, nano whisker mixture 0.3kg; Physcion methyl ether composite material is composed of physcion methyl ether and slow-release physcion methyl ether particles prepared in Preparation Example 1 at a mass ratio of 1:0.4; dispersant is composed of sodium lignin sulfonate and sucrose fatty acid ester at a mass ratio of 1:2; stabilizer is composed of The invention relates to a nanostructured nanoparticle mixture comprising sodium carboxymethyl cellulose and sodium alginate in a mass ratio of 1:1; a wetting agent comprising castor oil polyoxyethylene ether and glycerol in a mass ratio of 1:0.25; a defoaming agent comprising a silicone defoaming agent; high-fat pectin particles comprising the high-fat pectin particles prepared in Preparation Example 4; and a nanowhisker mixture comprising tetrapod-shaped zinc oxide whiskers and hydroxyapatite whiskers in a mass ratio of 1:1, wherein the average particle size of the tetrapod-shaped zinc oxide whiskers is 20 μm, and the average particle size of the hydroxyapatite whiskers is 10 μm. The preparation method is as follows: S1. Weigh the physcion methyl ether compound, dispersant, high-fat pectin particles, and water, mix and stir evenly to obtain a primary mixture; S2. Add stabilizer, wetting agent, defoamer and nano whisker mixture to the primary mixture, continue mixing and stirring to obtain a suspension.

[0043] Example 2: This example differs from Example 1 in that: 2.8 kg of physalis methyl ether compound, 1 kg of dispersant, 0.5 kg of stabilizer, 1 kg of wetting agent, 0.5 kg of defoamer, 350 kg of water, 0.5 kg of high-fat pectin particles, and 0.2 kg of nanowhisker mixture; the physalis methyl ether compound consists of physalis methyl ether and the sustained-release physalis methyl ether particles prepared in Preparation Example 2 in a mass ratio of 1:0.2; the dispersant consists of sodium lignin sulfonate and sucrose fatty acid ester in a mass ratio of 1:1; the stabilizer consists of sodium carboxymethyl cellulose and sodium alginate in a mass ratio of 1:0.5; the wetting agent consists of castor oil polyoxyethylene ether and glycerol in a mass ratio of 1:0.1; the defoamer is an organosilicon defoamer; the high-fat pectin particles are the high-fat pectin particles prepared in Preparation Example 5, and the nanowhisker mixture consists of tetrapod-shaped zinc oxide whiskers and hydroxyapatite whiskers in a mass ratio of 1:0.5.

[0044] Example 3: This example differs from Example 1 in that: 3.2 kg of physalis methyl ether compound, 1.5 kg of dispersant, 1 kg of stabilizer, 2 kg of wetting agent, 1 kg of defoamer, 400 kg of water, 1 kg of high-fat pectin particles, and 0.5 kg of nanowhisker mixture; the physalis methyl ether compound consists of physalis methyl ether and the sustained-release physalis methyl ether particles prepared in Preparation Example 3 in a mass ratio of 1:0.5; the dispersant consists of sodium lignin sulfonate and sucrose fatty acid ester in a mass ratio of 1:2; the stabilizer consists of sodium carboxymethyl cellulose and sodium alginate in a mass ratio of 1:1; the wetting agent consists of castor oil polyoxyethylene ether and glycerol in a mass ratio of 1:0.4; the defoamer is an organosilicon defoamer; the high-fat pectin particles are the high-fat pectin particles prepared in Preparation Example 6, and the nanowhisker mixture consists of tetrapod-shaped zinc oxide whiskers and hydroxyapatite whiskers in a mass ratio of 1:1.

[0045] Example 4: This example differs from Example 1 in that: No cellulose acetate microspheres were added during the preparation of the sustained-release physcion methyl ether microparticles.

[0046] Example 5: This example differs from Example 1 in that: No fucoidan solution was added during the preparation of sustained-release physcion methyl ether microparticles.

[0047] Example 6: This example differs from Example 1 in that: No sodium N-lauroyl sarcosinate was added during the preparation of the fucoidan solution for sustained-release physcion methyl ether microparticles.

[0048] Example 7: This example differs from Example 1 in that: No tetrapod-shaped zinc oxide whiskers were added to the nanowhisker mixture.

[0049] Example 8: This example differs from Example 1 in that: No sucrose fatty acid ester was added to the dispersant.

[0050] Comparative Example Comparative Example 1: The difference between this comparative example and Example 1 is that: No high-fat pectin particles and nano whisker mixture are added to the raw materials.

[0051] Comparative Example 2: This comparative example differs from Example 1 in that: The raw materials are replaced with physcion methyl ether composite material with the same mass of physcion methyl ether.

[0052] Comparative Example 3: This comparative example differs from Example 1 in that: No dispersants or stabilizers are added to the raw materials.

[0053] Performance testing 1. Stability testing The suspension concentrates were prepared using the methods of Examples 1-8 and Comparative Examples 1-3, 20 mL of each was placed in a 50 mL centrifuge tube, and centrifuged at 5000 rpm for 30 min. The centrifugal stability Sc was then calculated and the data recorded. The formula is: Sc = [1-(d1-d2) / d1]×100%; where d1 is the initial average particle size of the suspension, and d2 is the average particle size of the suspension after centrifugation.

[0054] 2. Prevention and control effect detection The suspension concentrate was prepared by the methods of Examples 1-8 and Comparative Examples 1-3, and 80 mL of the suspension concentrate was sprayed per acre. 80 mL of the suspension concentrate was diluted with 30 kg of water to obtain a sample. The sample was evenly sprayed on the surface of spinach leaves. The control effect on powdery mildew was recorded at 10 d and 45 d, and the data was recorded.

[0055] Table 1 Performance test table In combination with Examples 1-3 and Table 1, it can be seen that the suspension concentrate prepared in the present application has high stability during storage, is not prone to stratification and precipitation problems, and when the suspension concentrate is sprayed onto the surface of crop leaves, the control effect is good, and the suspension concentrate has a long action time, indicating that the suspension concentrate has good stability and biological activity on the surface of crop leaves, can protect crops for a long time, and increase crop yield.

[0056] Combining Example 1 and Examples 4-8 with Table 1, it can be seen that cellulose acetate microspheres were not added during the preparation of the sustained-release physcion microparticles in Example 4. Compared with Example 1, the centrifugal stability of the suspension prepared in Example 4 was worse than that in Example 1, and the control effect was worse than that in Example 1. This indicates that the addition of cellulose acetate microspheres can improve the stability of the suspension, and when the suspension acts on the surface of crop leaves, it can further promote the slow release of physcion, so that the suspension has good stability and biological activity on the surface of crop leaves, thereby enabling the suspension to control powdery mildew on spinach leaves for a long time.

[0057] No fucoidan liquid was added during the preparation of the sustained-release physcion microparticles in Example 5. Compared with Example 1, the centrifugal stability of the suspension prepared in Example 5 was worse than that in Example 1, and the control effect was worse than that in Example 1. This shows that the addition of fucoidan liquid can promote the slow release of physcion microparticles, and utilize the hygroscopic and adhesive effect of fucoidan to improve the adhesion stability of the suspension on the surface of crop leaves, thereby making the suspension have better stability and biological activity on the surface of crop leaves, and can prevent and control powdery mildew on the crop surface for a long time.

[0058] In the preparation process of the fucoidan solution for the sustained-release physcion ether microparticles in Example 6, sodium N-lauroyl sarcosinate was not added. Compared with Example 1, the centrifugal stability of the suspension prepared in Example 6 was worse than that in Example 1, and the control effect was worse than that in Example 1. This indicates that sodium N-lauroyl sarcosinate has a penetration and spreading effect on the surface of crop leaves, increases the contact area between physcion ether and the surface of crop leaves, and cooperates with the hygroscopic and adhesive effect of the fucoidan solution to ensure that the physcion ether composite material adheres to the crop leaves, thereby improving the stability and biological activity of physcion ether on the surface of crop leaves.

[0059] In Example 7, tetrapod-shaped zinc oxide whiskers were not added to the nanowhisker mixture. Compared with Example 1, the centrifugal stability of the suspension prepared in Example 7 was worse than that in Example 1, and the control effect was worse than that in Example 1. This indicates that the use of tetrapod-shaped whiskers in combination with needle-shaped whiskers to scratch the surface of crop leaves increases the contact area between the crop leaves and the physcion composite, thereby improving the adhesion stability and biological activity of the physcion composite on the surface of the crop leaves.

[0060] No sucrose fatty acid ester was added to the dispersant of Example 8. Compared with Example 1, the centrifugal stability of the suspension prepared in Example 8 was worse than that in Example 1, and the control effect was worse than that in Example 1. This shows that sucrose fatty acid ester can improve the stability of the suspension, and when the suspension acts on the surface of crop leaves, it can improve the adhesion stability of physcion on the surface of crop leaves, thereby having the advantage of long-term control of powdery mildew.

[0061] Combining Example 1 and Comparative Examples 1-3 with Table 1, it can be seen that high-fat pectin particles and nanowhisker mixture are not added to the raw materials of Comparative Example 1. Compared with Example 1, the centrifugal stability of the suspension prepared in Comparative Example 1 is worse than that of Example 1, and the control effect is worse than that of Example 1. This shows that the combination of high-fat pectin particles and nanowhisker mixture can improve the dispersion stability of the suspension, protect the slow release of physcion, and prolong the control effect of the suspension on the surface of crop leaves.

[0062] In Comparative Example 2, the raw materials were replaced with physcion methyl ether composite materials of equal mass. Compared with Example 1, the centrifugal stability of the suspension prepared in Comparative Example 2 was worse than that in Example 1, and the control effect was worse than that in Example 1. This shows that the addition of slow-release physcion methyl ether particles can further prolong the control time of the suspension, thereby having the advantage of long-term control of powdery mildew.

[0063] No dispersant and stabilizer were added to the raw materials of Comparative Example 3. Compared with Example 1, the centrifugal stability of the suspension prepared in Comparative Example 3 was worse than that in Example 1, and the control effect was worse than that in Example 1. This shows that the addition of dispersants and stabilizers can improve the dispersion uniformity and stability of the suspension during storage, and after acting on the surface of crop leaves, it can stably adhere to the surface of the leaves, thereby improving the release effect of the suspension on the surface of the crop leaves.

[0064] This specific embodiment is merely an explanation of the present application and is not a limitation of the present application. After reading this specification, those skilled in the art may make non-creative modifications to the present embodiment as needed, but as long as they are within the scope of the claims of the present application, they are protected by the patent law.

Claims

1. A physcion methyl ether suspension concentrate, characterized in that, The suspending agent comprises the following raw materials in parts by weight: 2.8-3.2 parts of physcion methyl ether compound, 1-1.5 parts of dispersant, 0.5-1 part of stabilizer, 1-2 parts of wetting agent, 0.5-1 part of defoamer, 350-400 parts of water, 0.5-1 part of high-fat pectin particles, and 0.2-0.5 part of nano whisker mixture.

2. A physcion methyl ether suspension concentrate according to claim 1, characterized in that: The physcion methyl ether composite material consists of physcion methyl ether and slow-release physcion methyl ether particles in a mass ratio of 1:0.2-0.

5.

3. A physcion methyl ether suspension concentrate according to claim 2, characterized in that, The sustained-release physcion methyl ether microparticles are prepared from cellulose acetate microspheres, fucoidan solution and physcion methyl ether microparticles in a mass ratio of 1:0.2-0.3:0.2-0.

4.

4. A physcion methyl ether suspension concentrate according to claim 3, characterized in that, The fucoidan solution is prepared by mixing a fucoidan solution and sodium N-lauroyl sarcosinate in a mass ratio of 100:1-2.

5. A physcion methyl ether suspension concentrate according to claim 1, characterized in that, The high-fat pectin particles are prepared by cooling a high-fat pectin solution at 80-85° C. to 30-32° C., breaking it up, and freeze-drying it. The high-fat pectin solution is prepared from high-fat pectin, white sugar, and 80-85° C. water in a mass ratio of 1:3-4:100-120.

6. A physcion methyl ether suspension concentrate according to claim 1, characterized in that, The nano whisker mixture consists of four-needle zinc oxide whiskers and hydroxyapatite whiskers in a mass ratio of 1:0.5-1.

7. A physcion methyl ether suspension concentrate according to claim 1, characterized in that, The dispersant consists of sodium lignin sulfonate and sucrose fatty acid ester in a mass ratio of 1:1-2.

8. A physcion methyl ether suspension concentrate according to claim 1, characterized in that, The stabilizer consists of sodium carboxymethyl cellulose and sodium alginate in a mass ratio of 1:0.5-1.

9. A physcion methyl ether suspension concentrate according to claim 1, characterized in that, The wetting agent consists of castor oil polyoxyethylene ether and glycerol in a mass ratio of 1:0.1-0.

4.

10. A method for preparing a physcion suspension concentrate according to any one of claims 1 to 9, characterized in that: The following steps are involved: S1. Weigh the physcion methyl ether compound, dispersant, high-fat pectin particles, and water, mix and stir evenly to obtain a primary mixture; S2. Add stabilizer, wetting agent, defoamer and nano whisker mixture to the primary mixture, continue mixing and stirring to obtain a suspension.

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