Externally applied blood cooling and acne eliminating traditional Chinese medicine composition and preparation method thereof

Abstract

The invention relates to an externally applied blood-cooling acne-eliminating traditional Chinese medicine composition and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine preparations. The composition is prepared from the following raw materials in parts by weight: 15 to 20 parts of cortex phellodendri, 15 to 30 parts of herba taraxaci, 15 to 30 parts of folium isatidis, 9 to 15 parts of herba violae, 9 to 15 parts of radix sophorae flavescentis, 15 to 30 parts of radix et rhizoma rhei, 9 to 15 parts of radix angelicae sinensis and 20 to 30 parts of radix trichosanthis. The traditional Chinese medicine composition has the advantages that the traditional Chinese medicine composition focuses on the mechanism that depression is dispersed to eliminate heat and toxin is decomposed to dissipate blood stasis, the depression-heat-toxin-blood stasis pathogenesis chain of acne is synchronously cut off in a multi-node manner through the compatibility of monarch, minister, assistant and guide, the traditional Chinese medicine aims of treating blood stasis and toxin simultaneously and clearing and removing blood stasis and toxin simultaneously are met, and 60 patients verify that the total effective rate reaches 92.5%, the acne symptom can be effectively improved, inflammatory papules and pustules can be relieved, and cyst nodules can be reduced; scar repair is promoted, and pigmentation is reduced.

Description

Technical Field

[0001] The invention relates to an external application traditional Chinese medicine composition for cooling blood and eliminating acne and a preparation method thereof, belonging to the technical field of traditional Chinese medicine preparations. Background Art

[0002] Acne is a common chronic inflammatory disease of the sebaceous glands and pilofollicles. According to statistics, approximately 85% of adolescents worldwide will suffer from acne at some stage in their lives. Acne not only affects patients' appearance but also places significant strain on their mental health, easily triggering negative emotions such as low self-esteem and anxiety, and severely reducing their quality of life.

[0003] Acne falls under the category of "lung-wind acne" and "facial pimples" in Traditional Chinese Medicine (TCM). Its pathogenesis is often attributed to stagnant heat in the lungs and stomach, accumulation of damp-heat, and blood stasis and phlegm. The pathogenesis of acne follows a four-step progression: "stagnation-heat-toxicity-stasis": initially, wind-heat attacks the surface (whiteheads and whiteheads), gradually infiltrating the qi and causing damp-heat to stagnate (inflammatory papules), then the toxicity accumulates, causing flesh to rot and pus to form (pustules), ultimately leading to blood stasis and phlegm stagnation (cysts and scars). This aligns with the theory in the "Surgery Qixuan" (Surgery Qixuan) that "all sores and ulcers are caused by stagnant qi and blood." The "Suwen: Qi Tongtian Lun" (Suwen: Qi Gong Tongtian Lun) states, "Sweating with dampness causes acne and epilepsy," emphasizing that the accumulation of damp-heat is the cause of the disease. The "Surgery Zhengzong" (Surgery Zhengzong) states, "Acne is related to the lungs, and is generally caused by stagnant blood heat," clarifying that the accumulation of heat and toxicity in the skin is the core pathogenesis.

[0004] Current clinical treatments for acne primarily rely on Western medications, but long-term use can easily lead to drug resistance and skin irritation. While traditional Chinese medicine topical application can directly reach the affected area, many dosage forms require a plaster cast, making application cumbersome. Chinese patent document CN 103720865 A (application number 201310708316.1) discloses a Chinese medicine facial mask for treating acne and its preparation method, effectively addressing the problem of topical acne treatment. The mask utilizes a combination of honeysuckle, wild chrysanthemum, dandelion, scutellaria, coptis root, prunella vulgaris, phellodendron, salvia miltiorrhiza, forsythia suspensa, lithospermum officinale, and moutan bark. The combined effects of these herbs create a synergistic effect, effectively dispelling wind, heat, and toxins, removing dampness, removing blood stasis, and dredging the meridians. This approach offers the advantages of convenient topical application and excellent efficacy. Existing treatment regimens rely on fixed prescriptions, fail to account for individual constitutions, and utilize a wide variety of medications, leading to significant potential risks. These approaches lack a traditional Chinese medicine (TCM) perspective, potentially failing to cure acne and leading to recurrences. Summary of the Invention

[0005] In view of the deficiencies in the prior art, the present invention provides a traditional Chinese medicine composition for external application for cooling blood and eliminating acne and a preparation method thereof. Targeting the pathogenesis of acne, which is "heat and toxic stagnation, and phlegm and blood stasis", the present invention adopts the methods of clearing away heat and toxic substances, activating blood circulation and dispersing stagnation, and taking into account the different syndrome types. In addition, a simple preparation method is provided to facilitate clinical promotion.

[0006] Disclosed is a traditional Chinese medicine composition for external application for cooling blood and eliminating acne. The composition comprises the following raw materials in parts by weight: 15-20 parts of phellodendron, 15-30 parts of dandelion, 15-30 parts of isatis indigotica, 9-15 parts of viola yedoensis, 9-15 parts of sophora flavescens, 15-30 parts of rhubarb, 9-15 parts of angelica, and 20-30 parts of trichosanthes.

[0007] Preferably, the composition comprises the following raw materials in parts by weight: 20 parts of Phellodendron amurense, 30 parts of Taraxacum mongolicum, 25 parts of Folium Isatidis, 12 parts of Viola yedoensis, 12 parts of Sophora flavescens, 15 parts of Rhubarb, 12 parts of Angelica sinensis, and 25 parts of Radix Trichosanthis.

[0008] Preferably, the composition can be added with the following raw materials according to the symptoms: red peony root, salvia miltiorrhiza, chuanxiong, poria, raw rehmannia, angelica dahurica, white peony root, liquorice, coptis root, forsythia, ophiopogon, in an amount of 9 to 15 parts by weight.

[0009] The application of the above-mentioned traditional Chinese medicine composition in preparing a traditional Chinese medicine facial mask for cooling blood and eliminating acne.

[0010] A method for preparing a blood-cooling and acne-eliminating Chinese medicine facial mask using the above-mentioned Chinese medicine composition comprises the following steps: (1) Medicinal material processing: Wash and dry the raw materials of the Chinese medicinal composition, and grind them into fine powder; (2) Fusion of medicinal properties: the fine powder obtained in step (1) is immersed in deionized water, filtered after soaking to obtain an extract, and then lyophilized after rotary evaporation to prepare a lyophilized powder of traditional Chinese medicine; (3) Stir-frying to enhance efficacy: stir-fry the freeze-dried powder of the Chinese medicine obtained in step (2); (4) Preparation of essence: The stir-fried powder obtained in step (3) was mixed with deionized water at a mass volume ratio of 1:(1-2) (g / mL) and ultrasonicated to obtain a facial mask essence; (5) Film formation: Place the mask base fabric into the mask essence obtained in step (4), and ultrasonicate to obtain a Chinese medicine mask.

[0011] Preferably, the fine powder in step (1) is sieved through a 110-130 mesh sieve.

[0012] Preferably, the soaking in step (2) is: warm soaking at 50-60°C for 2-3 hours.

[0013] Preferably, the frying in step (3) is as follows: stirring and frying at 110-130° C. for 10-20 minutes until the medicinal aroma is released.

[0014] Preferably, the ultrasonic treatment in step (4) is carried out by water bath ultrasonication at 40 to 60° C. for 20 to 40 minutes at an ultrasonic frequency of 20 to 35 kHz.

[0015] Preferably, the mask base fabric in step (5) is silk or non-woven fabric.

[0016] Preferably, the ultrasonic treatment in step (5) is carried out by water bath ultrasonication at 40 to 60° C. for 5 to 15 minutes at an ultrasonic frequency of 1.40 to 1.94 kHz.

[0017] The pharmacological effects of the Chinese medicine used in the present invention are as follows: Huang Bai: Bitter and cold, enters the kidney and bladder meridians, clears away heat and dampness, purges fire and detoxifies, and specializes in treating damp-heat and fire toxins that stagnate in the skin; "Zhenzhu Nang" records: "It treats sores and red eyes, and purges the fire."

[0018] Dandelion: Bitter, sweet, and cold, it enters the liver and stomach meridians, clears heat and detoxifies, reduces swelling and resolves stagnation; the "Compendium of Materia Medica" states that it "relieves heat and toxins, and disperses stagnant qi." Indications: Effective at relieving red, swollen, inflamed papules and pustules (due to stagnant heat and toxins), and improving facial oiliness.

[0019] Isatis indigotica: Bitter and cold, enters the Heart and Stomach Meridians, cools the blood, eliminates freckles, and clears excess heat in the blood. Bencao Zhengyi states: "It clears excess heat in the blood." Indications: Red, swollen nodules and cysts (blood heat and toxic stasis).

[0020] Viola yedoensis: bitter, pungent and cold, enters the heart and liver meridians, clears away heat and detoxifies, cools blood and reduces swelling; specifically drains heat and toxins from the blood, breaks up sores, carbuncles and nodules; "Complete Collection of Surgery" records that it "eliminates carbuncle and furuncle toxins, disperses pus before it forms, and breaks up pus after it forms."

[0021] Sophora flavescens: Bitter and cold, it enters the Heart and Liver meridians, clears heat and dampness, kills insects and relieves itching. According to the Compendium of Materia Medica, it "dispels wind and fire, and eliminates malignant sores." Indications: Excessive oil secretion with itching (damp-heat infiltration).

[0022] Rhubarb: Bitter and cold, it enters the spleen and stomach meridians. It clears heat and dredges the bowels, dissipates blood stasis and toxins, guides pathogens downward, cools the blood and detoxifies. According to the Materia Medica, it "applies to heat-induced swellings and dissolves retained blood." Indications: Constipation with acne (due to heat in the lungs, stomach, and intestines).

[0023] Angelica: Sweet and warm, enters the liver and spleen meridians, replenishes blood and activates blood circulation, removes blood stasis and promotes new blood circulation, is good at eliminating old nodules and repairing scar pigmentation; "Compendium of Materia Medica" states: "It can drain pus and relieve pain, and harmonize blood and promote tissue regeneration." Radix Trichosanthis: Sweet and slightly cold, it enters the Lung and Stomach meridians. It clears heat and promotes fluid production, astringes sores and discharges pus, and promotes wound healing. According to the "Medical Records of Chinese and Western Medicine," it is effective in treating carbuncles and ulcers throughout the body. Indications: It promotes the drying and astringing of pustules, repairs damaged skin, and reduces the formation of acne scars (due to heat toxicity damaging the Yin).

[0024] The present invention focuses on the correlation between acne morphology, disease stage and pathogenesis when dialectically treating acne, takes "clearing and cooling blood, resolving blood stasis and dispersing stagnation" as the basic treatment principle, and clinically selects a blood-cooling and acne-removing Chinese medicine composition for external application, with Phellodendron amurense, Taraxacum mongolicum and Isatis indigotica as the main ingredients in the prescription: Taraxacum mongolicum disperses stagnant heat and resolves inflammatory papules, Phellodendron amurense clears damp-heat in the lower burner, detoxifies and regulates lipids, and Isatis indigotica cools blood and clears spots, and directly resolves heat and toxins in the blood. The three medicines form a synergistic triangle of "dispersing, clearing and cooling blood", which is closely linked to the core pathogenesis of heat and toxin stagnation in acne. Viola yedoensis, Sophora flavescens, and Rhubarb serve as auxiliary ingredients. Viola yedoensis attacks toxins, dissolves hard masses, and aids in the expulsion of pus and toxins; Sophora flavescens eliminates dampness and heals sores; Rhubarb purges heat from the Yangming meridians and guides blood circulation and heat from the intestines. These three ingredients differentiate the damp-heat and stasis-induced acne pathological products by breaking up stagnation, drying dampness, and clearing blood stasis. Angelica sinensis, a sweet and warming tonic, and a cooling herb to prevent cold, cools and suppresses Qi and blood; while Radix Trichosanthis resolves phlegm and resolves stagnation, while its sweet and cooling properties prevent damage to Yin, maintaining a balance of "attacking the evil without harming the righteous." Assistant herbs: Add or subtract according to symptoms, guiding the meridians to the affected area and treating the diseased area accordingly. For severe blood heat, add Radix Rehmanniae and Radix Paeoniae Rubra to cool the blood and nourish Yin. For phlegm and stasis, add Salvia miltiorrhiza and Ligusticum chuanxiong to unblock the meridians and resolve stagnation. For severe damp-heat, add Poria cocos to strengthen the spleen and resolve dampness. For forehead pain, add Coptis chinensis to guide the herbs into the heart meridian, clearing heat and relieving depression. This achieves targeted treatment, enhancing the targetedness and effectiveness of treatment.

[0025] Beneficial effects: 1. The whole formula adheres to the principle that heat disappears when depression is dispersed, and blood stasis is resolved when toxins are resolved. Through the combination of "monarch, minister, assistant and envoy", it achieves multi-node simultaneous interruption of the "depression-heat-toxicity-stasis" pathogenesis chain of acne, which is in line with the essence of traditional Chinese medicine of "treating both blood stasis and toxins, and clearing and clearing at the same time". After verification by 60 patients, the total effective rate reached 92.5%. It can effectively improve acne symptoms, reduce inflammatory papules and pustules, shrink cysts and nodules, promote scar repair, and reduce pigmentation.

[0026] 2. Add, subtract and modify the prescription according to the different syndromes of the patients to achieve personalized treatment and meet the medical needs of different patients.

[0027] 3. The dosage form has been improved to an essence mask. Compared with the cumbersome operation of traditional Chinese medicine external application that requires the assistance of a plaster hard mask, it is more convenient to use, improves patient compliance, and helps to ensure the stability and sustainability of the treatment effect.

[0028] 4. The preparation method is simple and convenient for clinical promotion. DETAILED DESCRIPTION

[0029] The present invention will be further described below through specific examples. It should be noted that the following description is only for explaining the present invention and does not limit its content.

[0030] Example 1 A traditional Chinese medicine facial mask for external application for cooling blood and eliminating acne, comprising the following raw materials: 20g of Phellodendron amurense, 30g of Taraxacum mongolicum, 25g of Isatis indigotica, 12g of Viola yedoensis, 12g of Sophora flavescens, 15g of Rhubarb, 12g of Angelica sinensis, and 25g of Radix Trichosanthis. The mask is prepared according to the following steps: (1) Medicinal material processing: Wash and dry Phellodendron chinense, Taraxacum mongolicum, Isatis indigotica, Viola yedoensis, Sophora flavescens, Rhubarb, Angelica sinensis, and Radix Trichosanthis, grind them into fine powder respectively, and pass through a 120-mesh sieve for later use; (2) Fusion of medicinal properties: The fine powder obtained in step (1) is immersed in deionized water and soaked at 55°C for 2 hours. After soaking, the extract is filtered to obtain the extract, which is then lyophilized after rotary evaporation to prepare a lyophilized powder of the traditional Chinese medicine; (3) Stir-frying to enhance efficacy: Place the freeze-dried powder of the Chinese medicine obtained in step (2) in a heater at 120°C and stir-fry for 20 minutes until the aroma of the medicine is released; (4) Preparation of essence: The stir-fried powder obtained in step (3) was mixed with deionized water at a mass volume ratio of 1:1.5 (g / mL), and ultrasonicated in a water bath at 60°C for 30 minutes at an ultrasonic frequency of 30 kHz to obtain a facial mask essence; (5) Film formation: Place the mask base fabric (silk) into the mask essence obtained in step (4), and perform ultrasonic treatment in a 50°C water bath for 10 minutes at an ultrasonic frequency of 1.5 kHz to obtain a Chinese medicine mask.

[0031] Example 2 (wind-heat type in adolescence) A traditional Chinese medicine facial mask for external application that cools blood and eliminates acne, comprising the following raw materials: 15g of Phellodendron amurense, 15g of Taraxacum mongolicum, 15g of Isatis indigotica, 9g of Angelica sinensis, 9g of Viola yedoensis, 9g of Sophora flavescens, 15g of Rhubarb, 20g of Radix Trichosanthis, 9g of Coptis chinensis, and 9g of Forsythia suspensa, which has the effect of clearing the heart and purging fire; and the preparation method is the same as that of Example 1.

[0032] Example 3 (damp-heat type in young and middle-aged people) A traditional Chinese medicine facial mask for external application that cools blood and eliminates acne, comprising the following raw materials: 18g of Phellodendron amurense, 20g of Taraxacum mongolicum, 15g of Isatis indigotica, 9g of Angelica sinensis, 12g of Viola yedoensis, 12g of Sophora flavescens, 20g of Rhubarb, 30g of Radix Trichosanthis, 15g of Poria cocos, and 15g of Salvia miltiorrhiza, with an emphasis on promoting dampness and removing blood stasis; the preparation method is the same as that of Example 1.

[0033] Example 4 (Female Blood Heat Type) A traditional Chinese medicine facial mask for external application that cools blood and eliminates acne comprises the following raw materials: 15g of Phellodendron amurense, 30g of Taraxacum mongolicum, 30g of Isatis indigotica, 12g of Angelica sinensis, 15g of Viola yedoensis, 9g of Sophora flavescens, 15g of Rhubarb, 30g of Radix Trichosanthis, 15g of Paeonia lactiflora, 15g of Rehmannia glutinosa, 9g of Licorice root, 15g of Dictamni cortex, and 15g of Radix Ophiopogonis. The mask cools blood, nourishes yin, and moistens dryness. It is used for female facial flushing caused by blood heat stagnation, and focuses on clearing heat, cooling blood, and eliminating acne. The preparation method is the same as that of Example 1.

[0034] Example 5 (Post-acne recovery period) A traditional Chinese medicine facial mask for external application that cools blood and eliminates acne. The raw materials are as follows: 20g of Phellodendron chinense, 20g of Taraxacum mongolicum, 30g of Isatis indigotica, 15g of Angelica sinensis, 15g of Viola yedoensis, 15g of Sophora flavescens, 15g of Rhubarb, 30g of Radix Trichosanthis, 15g of Salvia miltiorrhiza, 15g of Angelica dahurica, and 9g of Ligusticum chuanxiong. This mask is used to promote blood circulation and dissipate pigmentation, and is used to prevent scars and reduce the occurrence of pigmentation in the later stages of acne. The preparation method is the same as that of Example 1.

[0035] Example 6 (Comparative Example) A traditional Chinese medicine facial mask for external application for cooling blood and eliminating acne, comprising the following raw material ratios: 30g of dandelion, 12g of viola yedoensis, 12g of sophora flavescens, 15g of rhubarb, 12g of angelica sinensis, and 25g of trichosanthes root, i.e., the basic formula minus phellodendron and isatis indigotica, and the preparation method is the same as that of Example 1.

[0036] Clinical effects After verification in 60 patients, the total effective rate was 92.5%. Typical cases are as follows: Case 1 The patient was a 23-year-old female who came to the hospital for treatment on February 24, 2024, because of "recurrent facial erythema and papules for two months." The symptoms worsened after eating greasy food, accompanied by mild pain. Physical examination showed scattered bright red papules, open comedones, and a small number of follicular pustules on the forehead and cheeks, with obvious tenderness; the tongue was red, with a thin yellow fur, and a slippery and rapid pulse. Western medicine diagnosed it as moderate acne vulgaris (grade II), which is classified as acne in traditional Chinese medicine, and the syndrome is heat and toxic accumulation. The treatment is to cool blood to clear heat, detoxify and disperse the stagnation, using the Chinese medicine mask prepared in Example 1 of the present invention, which is applied externally for 20 minutes daily.

[0037] On March 9, 2024, the second visit showed that the patient's facial pustules had subsided by nearly 80%, with no new pustules. The color of the original papules turned dark red, the pain disappeared, and the greasy feeling on the face was reduced. The tongue redness was reduced, the fur was thin and yellow, and the pulse was slippery. It is considered that there is still heat toxin lingering in the veins and blood stasis is beginning to appear. Adjustment plan: Add 15g of Danshen and 10g of Chishao to the prescription of Example 1 of the present invention to promote blood circulation, cool blood, and resolve blood stasis.

[0038] On March 23, 2024, the patient's facial pustules completely resolved, papules decreased by 70%, and dark red acne scars remained. A small amount of new acne occasionally appeared before menstruation. The tongue was pale red with a thin white coating, and the pulse was thready and slightly stringy. At this point, the heat toxins had cleared, and the pathogenesis shifted to blood stasis and liver depression (which aggravated the stagnation of Wei Qi before menstruation). Medication adjustments were made: Rhubarb and Viola yedoensis were removed from the formula of Example 1 of the present invention; the amount of dandelion was reduced to 15g to prevent cold and damage to Yin; 10g of Angelica dahurica was used for whitening and lightening; and the patient was advised to take 15g of rose flower as a tea substitute to soothe the liver and relieve depression.

[0039] At the fourth visit on April 20, 2024 (follow-up 8 weeks later), the patient had only a few light brown acne scars remaining, with one or two occasional comedones appearing with dietary irregularities, which resolved spontaneously. The tongue was pale red with a thin white coating, and the pulse was gentle. Residual heat was suspected to be accumulating in the yin, leading to incomplete harmony of qi and blood. Topical treatment was discontinued, and the patient was advised to avoid dairy products and high-sugar foods to prevent recurrence. At 3 months of follow-up, the patient's condition remained stable, with no recurrence of acne and a smooth, restored skin.

[0040] Case 2 The patient is a 24-year-old female who was first diagnosed on June 5, 2023 due to "recurrent facial acne for 3 years and aggravated for 2 months". Three years ago, acne began to appear on the face without obvious cause, mainly concentrated on the cheeks and forehead, sometimes light and sometimes heavy. In the past two months, due to high work pressure, long-term overtime work, and frequent consumption of spicy and greasy foods, the acne has been significantly aggravated. She used a variety of acne products on her own, but the effect was not good. The diagnosis showed that there were a large number of red papules and pustules on her face, some of which merged into nodules, which were painful to the touch, her face was greasy, accompanied by bad breath, constipation, and short and red urine. The tongue was red, the tongue coating was thick and greasy, and the pulse was stringy and slippery. The Chinese medicine diagnosis was acne (heat toxicity and blood stasis syndrome), and the treatment method was to clear away heat and toxins, and to promote blood circulation and remove blood stasis. Use the Chinese medicine mask made from Example 1 of the present invention and apply it externally for 20 minutes every day.

[0041] During the second visit on July 3, 2023, the patient reported reduced facial pain, fewer pustules, less frequent new rashes, improved constipation, and lighter urine color. However, numerous red papules remained on the face, and the skin was oily. The tongue was red, the coating yellow, and the pulse was stringy and slippery. The traditional Chinese medicine mask and wet compress regimen remained unchanged, and the patient was advised to continue a light diet, maintain a good mood, and avoid staying up late.

[0042] On August 7, 2023, at the third visit, the patient's facial acne had significantly subsided, with only a few pale red acne scars remaining. No new rashes had appeared. Facial oil secretion had decreased, bad breath had disappeared, bowel movements were normal, and urination was clear and long. The tongue was pale red with a thin white coating, and the pulse was stringy. The patient was advised to discontinue the use of traditional Chinese medicine masks and wet compresses and to use a mild cleanser daily. She should maintain skin moisturization and sun protection, maintain a regular sleep schedule, and eat a balanced diet, avoiding spicy, greasy, and sweet foods.

[0043] Case 3 The patient was a 24-year-old male who came to the clinic on May 4, 2022 due to "recurrent facial acne for one year". The patient had frequent facial acne in the past year. In the early stage, there were a small number of scattered papules, which gradually worsened. Now dense red papules and pustules can be seen, some of which are fused, with obvious pain and itching. His spirit, diet, and sleep have been normal since the onset of the disease. He has dry stools and yellow and red urine. He has no history of drug or food allergies or major diseases. After the four examinations of traditional Chinese medicine, the patient had facial papules, yellow and greasy tongue coating, dry mouth and bitter taste, dry stool, yellow and red urine, and slippery and rapid pulse. Western medicine diagnosed him with common acne. Traditional Chinese medicine diagnosed him with acne (heat, toxicity and blood stasis syndrome), and the treatment method is to clear away heat and detoxify, and promote blood circulation and remove blood stasis. Use the Chinese medicine facial mask made in Example 1 of the present invention and apply it externally for 20 minutes every day. At the same time, advise him to avoid spicy, greasy and sweet foods, have a regular work and rest schedule, and keep his face clean.

[0044] On June 1, 2022, the patient reported that the pain was relieved and the number of new papules decreased. Examination showed that the pustules were significantly reduced, some of which had scabs, and the inflammation was relieved. Local fire needle treatment was given, and the Chinese medicine mask of Example 1 of the present invention was continued for external application, and the condition was observed.

[0045] On June 29, 2022, the third visit showed that most of the papules and pustules on the patient's face had dried up and subsided, with only sporadic new rashes and reduced oiliness of the skin. The patient was still allowed to continue using the Chinese medicine mask of Example 1 of the present invention to consolidate the treatment, and the importance of skin care and diet regulation was emphasized.

[0046] On July 23, 2022, the patient strictly followed the doctor's instructions, persisted in using the Chinese medicine mask, and maintained a healthy lifestyle. The facial rash had almost completely subsided, leaving only a small amount of pigmentation, and no new rashes had appeared. The patient was very satisfied with the treatment results. The patient was advised to continue to maintain a healthy lifestyle and to return for a follow-up visit if acne recurred.

[0047] Case 4 The patient is a 17-year-old male who was first diagnosed on May 8, 2024 due to "recurrent facial erythema and cysts for 3 years". Current medical history: 3 years ago, erythema, papules and cysts appeared on the bilateral cheeks and forehead, accompanied by mild pain. The external hospital diagnosed him with moderate acne vulgaris and gave him oral doxycycline and topical isotretinoin erythromycin gel. The initial effect was good but the disease recurred after discontinuation of the drug. The four diagnostic methods of traditional Chinese medicine: red and greasy face, red tongue, thick and greasy yellow fur, slippery and rapid pulse, the disease belongs to acne in traditional Chinese medicine, and the syndrome belongs to heat and toxicity combined with hyperactivity of heart fire. The Chinese medicine facial mask prepared in Example 2 of the present invention was applied externally for 20 minutes daily.

[0048] Second visit on June 5, 2024 (4 weeks of treatment): Facial erythema subsided by 50%, forehead rash subsided significantly compared to the previous visit, cysts shrank by 30%, tongue redness decreased, tongue coating was thin and yellow, and pulse was smooth. Adjustment: Based on the formula of Example 2 of the present invention, reduce the coptis root and add 15g of Imperata root to enhance heat-clearing and blood-cooling effects.

[0049] Third visit on July 3, 2024 (8 weeks of treatment): Papules have subsided 80%, cysts have essentially resolved, leaving 4 dark red acne scars. The tongue is pale red with a thin white coating, and the pulse is thready and slightly astringent. Treatment has been changed to promoting blood circulation and removing blood stasis: Based on the formula of Example 2 of the present invention, remove the rhubarb and add 15g of red peony root and 12g of angelica to promote scar repair and reduce pigmentation.

[0050] Fourth visit on August 7, 2024 (12 weeks of treatment): Acne completely resolved, skin texture restored, VISIA Propionibacterium count decreased by 95%, and GAGS score decreased from 28 to 2. Tongue pale red with a thin white coating, pulse smooth. Consolidation plan: Apply a facial mask every other week to maintain efficacy, and avoid spicy foods.

[0051] Case 5 The patient is a 14-year-old male who came to the clinic on October 5, 2022 because of "recurring rash on the forehead for more than half a year". The patient has been under great academic pressure in the past six months. At first, a small amount of acne appeared on the forehead, but he did not pay attention to it. Later, it gradually developed into dense papules and pustules and partially fused, accompanied by mild pain. He described himself as irritable, insomniac, and short and red urine. He had a normal diet and had no drug or food allergies or major medical history. Specialist physical examination: acne and red papules were densely distributed on the forehead, distributed in isolation, and there were relatively few rashes on other parts of the face. The four examinations of traditional Chinese medicine showed that the face was slightly red, the tip of the tongue was red and prickly, the tongue coating was thin, yellow and dry, and the pulse was fine and strong. Western medicine diagnosed it as moderate common acne, which is classified as acne in traditional Chinese medicine. The syndrome is hyperactivity of heart fire, stagnation of heart qi and blood in the skin, and acne. The Chinese medicine mask prepared in Example 2 of the present invention was applied externally for 20 minutes every day.

[0052] On November 2, 2022, the patient came for a follow-up visit. He said that his irritability symptoms had been alleviated, but he still suffered from insomnia, and new rashes still appeared from time to time. After another four-diagnosis Chinese medicine consultation, it was found that the red tip of the tongue had been slightly alleviated, but there were still red thorns, the tongue coating was still thin and yellow, and the pulse was still rapid but slightly weaker. This is because the heart fire has been alleviated, but it has not been completely cleared, and the remaining evil still disturbs the mind and skin. Adjust the treatment plan, continue to use the Chinese medicine mask of Example 2 of the present invention, add 10 grams each of lotus seed heart and light bamboo leaf, decoct in water, take 1 dose per day, and take it warm twice a day in the morning and evening. Lotus seed heart can directly enter the heart meridian, clear away heat and purge fire, and connect the heart and kidney; light bamboo leaf clears heat and relieves irritability, promotes diuresis and relieves stranguria, so that the heart fire is expelled through urination. The combination of the two enhances the effect of clearing the heart and purging fire. At the same time, it is recommended to continue to adjust your life and closely observe the condition.

[0053] The third visit was on November 30, 2022, the second follow-up visit 8 weeks after the first visit. The patient reported that his sleep had improved significantly, his irritability symptoms had basically disappeared, and the forehead rash had mostly subsided. The fourth visit showed that the color of the tip of the tongue had basically returned to normal, the tongue coating had turned thin and white, and the pulse was calm. This indicated that the heart fire had been cleared and the condition had improved significantly. Therefore, the treatment was adjusted to a Chinese medicine mask once a week and a Chinese medicine decoction once every two days to consolidate the therapeutic effect. At the same time, the key points of daily diet, work and rest, and emotional regulation were emphasized again to prevent acne recurrence.

[0054] Case 6 The patient is a 17-year-old female patient who came to the clinic on January 5, 2023 because of "recurring facial papules for more than a year". In the past year, the patient's facial acne has been one after another, mainly on the forehead and cheeks. It started with whiteheads and blackheads, and gradually developed into red papules and pustules. The patient is in her third year of high school, with great academic pressure, irregular work and rest, and often stays up late to study. She is prone to dry mouth and dry stools, and has one every 2-3 days. The menstrual cycle is still regular, but premenstrual acne will worsen. Inspection shows that the facial skin is greasy, the acne is densely distributed, the color is bright red, the tip of the tongue is red, and the fur is thin and yellow; the pulse is floating and rapid. Western medicine diagnoses it as common acne, Chinese medicine disease is acne, and the syndrome is heat and toxicity combined with wind-heat syndrome of the lung meridian. The Chinese medicine mask prepared in Example 2 of the present invention is used and applied externally for 20 minutes every day. At the same time, the patient is advised to eat a light diet, avoid spicy and greasy foods, go to bed early and get up early, and soothe the mood.

[0055] On the second visit on February 2, 2023, the facial pustules decreased, the original red papules became lighter in color, and the thin yellow tongue coating subsided slightly; the pulse was still floating, but the pulse was weakened. This is because the wind-heat evil in the lung meridian has been alleviated, but the problem of heat in the body disturbing the mind still exists. On the basis of maintaining the use of the Chinese medicine mask in Example 2 of the present invention, 10 grams each of mulberry bark and lily are added and taken as tea. One dose is taken per day. Mulberry bark clears away lung heat, and lily calms the mind and soothes the nerves, which together have the effect of clearing lung heat and soothing the mind. At the same time, the daily routine and dietary precautions are emphasized.

[0056] The third visit was on March 2, 2023. Inspection revealed that the facial acne had mostly subsided, leaving only a few acne scars. The tip of the tongue was slightly red, with a thin white coating. Questioning revealed that insomnia and frequent dreams had improved, and bowel movements were almost normal. Palpation revealed a normal pulse. This indicated that the wind-heat in the lung meridian had cleared, and bodily functions were gradually returning to normal. The treatment plan was adjusted, with the use of Chinese herbal facial masks reduced to twice a week to consolidate the therapeutic effect. The patient was advised to maintain a healthy lifestyle and to return for follow-up visits promptly if a relapse occurred.

[0057] Case 7 The patient is a 32-year-old male who came to the clinic on January 5, 2024 because of "recurrent facial acne for 1 year and aggravation for 1 month". The patient has had recurrent facial acne in the past year, sometimes mild and sometimes severe. In the past month, due to high work pressure, often staying up late, and liking to eat spicy and greasy food, the acne has been significantly aggravated. The facial rash is mainly red papules, pustules, and nodules, accompanied by pain, and some rashes are fused into pieces. He feels that his skin is greasy, his breath is obvious, his stool is sticky and uncomfortable, and he has one bowel movement every 2-3 days, and his urine is yellow and red. There is no obvious fever, chills, joint pain and other discomfort. His sleep is normal, and he wakes up easily due to frequent dreams. Specialist physical examination: the facial skin is greasy, with scattered red papules, pustules, and nodules, some of which are fused, the tongue coating is yellow and greasy, and the pulse is slippery and rapid. Western medicine diagnosis: acne; Chinese medicine disease is acne, and the syndrome is gastrointestinal damp heat. Treatment plan: Use the Chinese medicine mask made from Example 3 of the present invention for 20 minutes a day. Life advice: Eat a light diet, avoid spicy, greasy, and sweet foods; maintain a regular schedule and avoid staying up late; keep a good mood.

[0058] On January 24, 2024, the second visit showed that the number of red papules, pustules, and nodules on the patient's face decreased, the color became lighter, the pain was relieved, and the greasy feeling of the skin was slightly relieved. The bad breath was relieved, the bowel movements were smoother than before, one every 1-2 days, and the urine color was slightly lighter. The tongue coating was still yellow and greasy, but thinner than before, and the slippery pulse was less severe than before. The patient continued to apply the Chinese medicine facial mask according to Example 3 of the present invention twice a week; and took red bean and barley porridge on a daily basis to enhance the diuretic effect.

[0059] At the third visit on February 21, 2024, the patient's face showed only a small amount of residual pigmentation, with no new papules or pustules, and her skin had essentially returned to normal. Her breath was normal, her bowel movements were normal once daily, and her urine was clear and long. Her tongue had a thin yellow coating, and her pulse was normal. She was prescribed a traditional Chinese medicine facial mask twice weekly for another two weeks before discontinuing it. She continued to maintain a healthy lifestyle to prevent recurrence of acne.

[0060] Case 8 The patient is a 31-year-old female patient who first came to the clinic on May 19, 2024, due to "recurrent facial erythema and papules for one year, aggravated before menstruation and accompanied by scarring." Current medical history: dark red spots and nodules appeared around the mouth and mandible one year ago, and the lesions increased before menstruation and left depressed scars. Topical adapalene gel and clindamycin had little effect. She had a history of "polycystic ovary syndrome" for 5 years. Four Chinese medicine examinations: greasy face, dark red tongue with petechiae, greasy yellow tongue coating, and deep and sluggish pulse. Western medicine diagnosis: papular nodular acne (moderate grade II); Chinese medicine disease is acne, and the syndrome is damp-heat and blood stasis combined with Chong and Ren disorders. Treatment plan: Use the Chinese medicine facial mask prepared in Example 3 of the present invention for 20 minutes a day. Avoid high-sugar and high-fat diets; gynecological department cooperates to regulate polycystic ovary.

[0061] Second visit on June 16, 2024 (4 weeks of treatment): Inflammatory nodules subsided by 70%, 2 new papules appeared before menstruation, tongue petechiae decreased, tongue coating was thin and yellow, and pulse was stringy and slippery. Adjustment: Based on the formula of Example 3 of the present invention, reduce the amount of rhubarb to 15g, and add 10g of salvia miltiorrhiza to nourish blood and disperse nodules.

[0062] Third visit on July 14, 2024 (eight weeks of treatment): Facial papules have essentially resolved, leaving three atrophic scars and superficial pigmentation. The tongue is pale red with a thin white coating and a thready pulse. Treatment has been switched to removing stasis and promoting tissue regeneration: Based on the formula of Example 3 of the present invention, remove Sophora flavescens and Viola yedoensis and add 12g of Angelica dahurica and 9g of Ligusticum chuanxiong to promote epidermal repair.

[0063] Fourth visit on August 11, 2024 (12 weeks of treatment): No new acne, scar softening (VISIA test collagen density restored to 85%), tongue and pulse normal. Topical application treatment discontinued.

[0064] A follow-up examination 5 months after treatment (December 2024) showed that the face was smooth, there was no new rash before menstruation, and the polycystic ovary-related androgen level decreased (free testosterone 1.8ng / dL→1.2ng / dL). At the last follow-up (February 20, 2025), the condition remained stable.

[0065] Case 9 The patient is a 20-year-old male who came to the hospital for treatment on October 20, 2023 due to "facial papules and nodules for 2 years". In the past two years, erythema and papules have recurred on the face, gradually developing into pustules, cysts and nodules. He has used a variety of acne products on his own, but the effect is not good. He usually likes spicy and greasy food, has irregular work and rest, and often stays up late. Accompanied by bad breath, constipation, and short and red urine. Current symptoms: widespread erythema on the face, dense papules and pustules, cysts and nodules, some of which are fused and painful to touch. Red tongue, yellow and greasy fur, slippery and rapid pulse. Western medicine diagnosis: severe common acne. Traditional Chinese medicine disease belongs to acne, and the syndrome belongs to heat toxins and blood stasis combined with gastrointestinal damp-heat syndrome. Treatment plan: Use the Chinese medicine mask made from Example 3 of the present invention for 20 minutes a day.

[0066] On November 10, 2023, the patient underwent a second visit. Symptoms were as follows: the facial erythema had lightened in color, the pustules had decreased, the pain had eased, and a small number of new papules still appeared. The patient's bowel movements were regular, with 1-2 bowel movements daily, and the bad breath had decreased. The tongue was pale red with a thin, greasy, yellow coating, and a slippery pulse. Treatment: Based on the formula in Example 3 of the present invention, the dosage of Danshen was increased to 30g to promote blood circulation and dissipate blood stasis, promoting the resolution of cysts and nodules.

[0067] On December 1, 2023, the patient returned for a third visit. Symptoms: Only a small amount of facial pigmentation remained, with no new papules, pustules, cysts, or nodules. Skin oil secretion decreased, and the patient's perceived symptoms improved significantly. The tongue was pale red, with a thin white coating and a thready pulse. Treatment plan: Continue applying the herbal facial mask twice weekly, then discontinue after two weeks. Avoid rich and greasy foods, increase outdoor exercise, and maintain a healthy work and rest schedule.

[0068] Case 10 A 33-year-old female patient presented to the hospital for the first time on May 26, 2024, with "recurrent facial erythema and papules, accompanied by burning and itching, for four months." Current medical history: Sudden onset of facial erythema and pustules four months ago. Application of topical benzoyl peroxide gel reduced the papules, but resulted in skin sensitization (positive lactic acid sting test), with paroxysmal burning and exacerbated nocturnal itching. Physical examination: Diffuse, rice-sized erythema and papules (GAGS score 16) on the forehead and cheeks, with tenderness. A red tongue with red spots on the edges and tips, a thin, dry, yellow tongue coating, and a thready, rapid pulse. Traditional Chinese Medicine diagnosis: acne-blood heat congestion syndrome; Western Medicine diagnosis: moderate inflammatory acne (grade II) with impaired skin barrier. Treatment: Apply the Chinese medicine facial mask prepared in Example 4 of the present invention for 20 minutes. Avoid high-protein diets and dairy products; use a medical cold spray for sedation.

[0069] Second visit on June 9, 2024 (two weeks of treatment): Erythema subsided by 40%, the VAS score for burning sensation decreased from 7 to 4, two new small papules with desquamation appeared, the tongue redness decreased, the tongue coating was thin and white, and the pulse was stringy and fine. Adjustment: Based on the formula of Example 4 of the present invention, the dosage of rhubarb was reduced to 9g to prevent yin deficiency, and 12g of white peony root was added to dispel wind and relieve itching.

[0070] Third visit on June 30, 2024 (5 weeks of treatment): Papules completely resolved, leaving light red marks, and skin tolerance improved (TEWL value 14.2 → 10.5 g / h·m²). Tongue pale red with scanty fur, right cun pulse weak (lung yin deficiency). Treatment: To nourish yin and promote meridian circulation: Based on the formula of Example 4 of the present invention, remove Sophora flavescens and Viola yedoensis and add 15 g of Ophiopogon japonicus and 12 g of Salvia miltiorrhiza.

[0071] Fourth visit on July 21, 2024 (8-week treatment concluded): No new acne, facial erythema index (VISIA erythema area) decreased by 82%, and tongue and pulse were normal. Consolidation plan: Once a week, use a facial mask combined with hyaluronic acid repair lotion. Avoid alcohol-containing skincare products.

[0072] Follow-up results: Six months after treatment (November 26, 2024), the skin condition was stable, the collagen density at the original scar recovered to 91% (skin ultrasound detection), and the facial lactic acid sting test turned negative; at the last follow-up (February 16, 2025), no recurrence was observed, and there was no irritation reaction in the tolerance test (Stinging test).

[0073] Case 11 A 40-year-old female patient came to our hospital on April 2, 2023 because of "facial papules for 2 years, aggravated for 2 months". The patient had recurrent acne on her face for the past 2 years, concentrated on the forehead, cheeks, and chin, with high sebum secretion. Initially, the acne was mild and not taken seriously, but later it worsened. She used tretinoin ointment on her own, but long-term use made her facial skin sensitive, with paroxysmal flushing, accompanied by burning and stinging sensations, which worsened after exposure to heat, emotional excitement, and spicy food. She came to our hospital for further treatment. Since the onset of the disease, her spirit and sleep have been good, she likes spicy food, and her bowel movements are regular. She denied a history of drug and food allergies and had no history of other chronic diseases. Her menstrual cycle is regular, with moderate menstrual flow and occasional dysmenorrhea. She denied a family history of genetic diseases. Current symptoms: flushing of the face and cheeks, scattered red papules and acne, dry and scaly skin. The tongue is red, with a thin yellow fur, and a stringy and rapid pulse. The Traditional Chinese Medicine diagnosis is acne-blood heat congestion syndrome; the Western Medicine diagnosis is moderate inflammatory acne (Grade II) with impaired skin barrier. Treatment plan: Apply the traditional Chinese medicine facial mask prepared in Example 4 of the present invention for 20 minutes. Avoid high-protein foods and dairy products; use a medical cold spray to soothe the skin. Discontinue use of irritating cosmetics and skincare products, and use mild, restorative medical skincare products.

[0074] On April 23, 2023, the patient underwent a second visit. Symptoms were as follows: facial burning and stinging had slightly subsided, flushing had slightly improved, and existing papules and acne had mostly resolved, with no new ones. The patient had a red tongue with a thin, yellow coating and a rapid, wiry pulse. Treatment plan: The patient's blood-heat symptoms had subsided, and she continued to use a traditional Chinese medicine facial mask. Minocycline was also added to reduce local inflammation, and medical skincare products were used to restore the skin's barrier function.

[0075] Third visit on May 14, 2023 Facial acne has largely subsided, leaving only a small amount of pigmentation, with no discomfort, and the skin barrier is gradually recovering. Treatment plan: Discontinue minocycline and continue applying the herbal mask twice a week for another two weeks. Focus on functional restoration of the skin barrier and adjust your lifestyle to prevent recurrence.

[0076] Case 12 The patient is a 34-year-old female patient who was first diagnosed on January 5, 2024 due to "recurring facial acne for 1 year". The patient has had facial acne one after another for a year, and often applies various acne-removing products on her own, but the effect is not good. Recently, a burning and stinging sensation has appeared on the face. Scattered red papules and pustules can be seen on the face, some of which are fused, the skin is flushed, and the burning and stinging are obvious. Accompanied by irritability and thirst, dry stools, short and red urine, red tongue, yellow fur, and rapid pulse. Based on the comprehensive symptoms and tongue and pulse, Chinese medicine diagnosed it as acne, the syndrome belongs to heat and toxicity, and Western medicine diagnosed it as common acne. Use the Chinese medicine mask made from Example 4 of the present invention and apply it externally for 20 minutes every day.

[0077] The second visit was on January 19, 2024. The current symptoms were: facial flushing has eased, but there is still a burning sensation, a small number of new erythema and papules, and dry stools. In view of the signs of blood heat, the Chinese medicine facial mask is continued to be applied externally. At the same time, in combination with the pricking and bloodletting therapy, acupoints such as Dazhui and Feishu are selected. After routine disinfection, a three-edged needle is used to prick and bleed to release a small amount of blood stasis to relieve heat and toxins and dredge the meridians. This is done once every 2 weeks.

[0078] On February 2, 2024, the patient's third visit revealed less burning and stinging sensation on the face, fewer new acne outbreaks, and lighter coloration of some existing papules. Bowel movements were regular, but urine remained yellowish. The tongue was red with a thin, yellow coating, and a slightly rapid pulse. Treatment with a traditional Chinese medicine mask, bloodletting, and cupping was continued. The mask was applied as before, bloodletting was continued as planned, and cupping was performed once a week. The patient was also advised to maintain a light diet, avoid spicy and greasy foods, drink plenty of warm water, and maintain a good mood.

[0079] Fourth visit, March 2, 2024. Current symptoms: Facial flushing and burning pain have significantly improved; pustules have largely subsided, leaving only a few red papules; urine color has returned to normal; tongue is pale red with a thin white coating; pulse is slightly rapid. The herbal mask is continued; bloodletting can be reduced to once every three weeks; cupping continues weekly. The patient is advised to maintain a regular sleep schedule, avoid staying up late, and engage in moderate exercise to promote metabolism.

[0080] On March 16, 2024, the patient's facial acne had essentially resolved, with only minor pigmentation remaining. She had no significant discomfort, and her tongue and pulse were normal. Bloodletting and cupping were discontinued, and herbal facial masks were administered once a week for 2-3 weeks of consolidation. The patient was advised to maintain daily skin cleansing and moisturizing, and to maintain a balanced diet to prevent acne recurrence.

[0081] Case 13 The patient is a 24-year-old male who first visited the hospital on October 23, 2024, for "recurrent facial erythematous papules for half a year, accompanied by nodular pain and hypertrophic scars." Current medical history: Six months ago, widespread facial erythema and nodules were reported. Niuhuang Xiaoyan Pills were given orally at an external hospital with poor efficacy. The four diagnostic methods of traditional Chinese medicine showed that the face was greasy and dirty, the tongue was dark red with ecchymosis, the tongue coating was thick and greasy yellow, and the pulse was stringy and astringent. The syndrome was characterized by acne-toxic stasis, obstruction of the collaterals and facial rash. Western medicine diagnosed the patient as severe acne vulgaris, grade IV (with hypertrophic scars). The Chinese medicine mask prepared in Example 5 of the present invention was applied externally for 20 minutes daily.

[0082] Second visit, November 6, 2024 (two weeks of treatment): Inflammatory papules reduced by 50%, pustules atrophied, and some scarring remained. Tongue ecchymosis subsided slightly, tongue coating thin yellow, pulse stringy and slippery. Adjustment: Topical application of scar-removing silicone gel to improve acne scarring.

[0083] Third visit on November 20, 2024 (4 weeks of treatment): The nodules softened and shrank, the tongue was pale red with a thin white coating, and the right Guan pulse was weak. Treatment method: Combined clearing and tonifying: Based on the formula recorded in Example 5 of the present invention, remove Sophora flavescens and add 12g of Atractylodes macrocephala and 10g of Poria to strengthen the spleen and eliminate dampness.

[0084] December 18, 2024 (8-week treatment conclusion): The rash has subsided by 95%, the scar area has been covered with new epithelium (the scar area has been reduced to 12% under VISIA ultraviolet light mode), and the tongue and pulse are normal. Consolidation plan: Every other week, topical application combined with asiatica glycoside cream to repair the barrier.

[0085] At the last follow-up (February 12, 2025), the skin condition was stable.

[0086] Case 14 The patient is a 26-year-old male who was first diagnosed on April 10, 2024 due to "recurrent facial pustules for 3 years and aggravated for 6 months". Over the past 3 years, the patient has had frequent attacks of facial acne. He did not receive systematic treatment in the early stage and often squeezed pimples on his own, and his condition gradually worsened. Although the number of acne attacks has decreased in the past six months, scars and obvious pigmentation have been left on the face, which seriously affect the appearance, causing the patient to have low self-esteem, dare not communicate with others, and significantly reduce social activities. Current symptoms: pustules, papules, hypertrophic scars of varying sizes, depressed scars, and large areas of dark brown pigmentation can be seen on the face. Accompanied by irritability, insomnia, dry stools, yellow and red urine, red tongue, thin yellow fur, and stringy pulse. Chinese medicine diagnosed it as acne, which belongs to the syndrome of phlegm and blood stasis, and Western medicine diagnosed it as post-acne scars and pigmentation. Use the Chinese medicine mask made from Example 5 of the present invention and apply it externally for 20 minutes every day. After taking off the mask, gently massage the mask essence until it is absorbed to promote scar softening and pigmentation dissipation.

[0087] In addition, in conjunction with facial fire needle therapy, select facial scars and pigmentation areas, disinfect them locally, and quickly prick them with fire needles once a week to stimulate local blood circulation, improve blood circulation in scar tissue, and promote skin repair.

[0088] On April 24, 2024, the second visit, the patient reported that the pain symptoms were alleviated and the sleep quality was slightly improved, but the changes in scars and pigmentation were not obvious. Continuing the current treatment plan, the mask ingredients of Example 5 of the present invention were adjusted to 21g of Rehmannia glutinosa and 9g of Angelica dahurica to cool the blood and promote the production of body fluids, and to harmonize qi and blood. At the same time, the patient was advised to keep the face clean, avoid scratching, eat a light diet, and eat more foods rich in vitamin C and vitamin E.

[0089] On the third visit on May 11, 2024, the facial scars had softened slightly, the pigmentation had lightened slightly, the bowel movements had returned to normal, the urine was still slightly yellow, and the patient's mood had improved. The Chinese medicine formula was adjusted, removing the rhubarb from the formula of Example 5 and adding 15g of salvia miltiorrhiza to enhance the blood circulation and stasis removal effect. The patient was advised to exercise appropriately and maintain a positive attitude.

[0090] Follow-up on June 8, 2024, showed that the facial scar had softened and flattened significantly, with significantly reduced pigmentation, with only minor marks visible under strong light. The patient's confidence had increased, and social activities had increased. The patient was advised to practice daily sun protection and use mild whitening skincare products to consolidate the treatment effects and prevent recurrence.

[0091] Case 15 The patient is a 34-year-old female patient who came to our hospital for treatment on March 16, 2023 due to "recurrent facial acne for 4 years". The patient had repeated erythema, papules, nodules, cysts, pain and discomfort since 4 years ago. She had been treated in many hospitals and was treated with isotretinoin capsules. After treatment, the cysts and nodules were significantly reduced compared with before, but there were still new papules. She could not take the above-mentioned drugs because she was preparing for pregnancy, so she came to our hospital for treatment. Current symptoms: erythema and papules on the cheeks and mandible, scattered pigmentation and raised dark red patches. Diagnosis: acne, Chinese medicine syndrome belongs to phlegm and blood stasis. Give the Chinese medicine facial mask of Example 5 of the present invention for external application for 20 minutes a day. Instruct the patient to return for a follow-up visit 4 weeks and 8 weeks after treatment, calculate the date, and supplement the relevant symptoms and signs at the follow-up visit, and treat it according to Chinese medicine dialectical treatment.

[0092] On April 13, 2023, the second visit showed the following symptoms: the color of the erythema on the cheeks and mandible had faded, the number of papules had decreased slightly, the scattered pigmentation had not changed significantly, the texture of the raised dark red patches had softened slightly, the pain had basically disappeared, but there was still slight tenderness. Treatment plan: Adjust the composition of the mask drug, add 15g of peach kernel to the formula of Example 5 of the present invention to enhance the effect of promoting blood circulation and removing blood stasis; add 9g of Fritillaria thunbergii to enhance the effect of removing phlegm and dispersing nodules. Instruct the patient to pay attention to facial cleanliness and avoid spicy, greasy and sweet foods.

[0093] On the third visit on May 11, 2023, the patient's current symptoms were as follows: facial erythema had essentially subsided, with only a few scattered pale red papules. Pigmentation had significantly decreased, and the raised dark red patches had significantly shrunk and flattened, approaching normal skin. The patient was advised to continue to maintain good living habits to consolidate the treatment effects and prevent acne recurrence.

[0094] Case 16 The patient is an 18-year-old male who came to the hospital for treatment on October 15, 2023 because of "recurrent facial papules and pustules for 3 months." In the past 3 months, the patient began to have red papules and pustules on his face without obvious cause, mainly distributed in the forehead, cheeks and mandible, accompanied by pain and occasional itching. He prefers spicy and greasy food. He denies any history of drug allergies. Specialist physical examination: Densely distributed red papules and pustules can be seen on the forehead, cheeks and mandible, some of which are fused into pieces and painful to touch. The tongue coating is yellow and greasy, and the tip of the tongue is red. The pulse is slippery and rapid. The Chinese medicine diagnosis is acne, which is due to heat and toxic accumulation, and the Western medicine diagnosis is common acne. Use the Chinese medicine mask prepared in Example 6 of the present invention and apply it externally for 20 minutes every day.

[0095] On November 12, 2023, the second visit showed symptoms of greasy feeling on the face, new papules, papule-vesicle pustules, red tongue, and yellow greasy. Considering the obvious signs of damp heat, the treatment was based on clearing heat and dampness, cooling blood and detoxifying, and adjusting the mask ingredients. On the basis of the formula of Example 6 of the present invention, 20g of Phellodendron chinense and 30g of Isatis indigotica were added.

[0096] On December 10, 2023, the patient returned for the third visit. Symptoms were as follows: no new papules had appeared on the face, the number of existing pustules had decreased significantly, and the greasiness had improved. The patient was advised to continue using the facial mask once daily. High-sugar and high-protein diets were avoided.

[0097] The fourth visit on December 21, 2023, current symptoms are: pustules and papules have basically subsided, and the greasy feeling has been reduced.

[0098] Case 17 The patient is a 24-year-old female. She came to the hospital for treatment on June 8, 2024 because of "recurrent facial papules and pustules for 4 months". In the past 4 months, the patient began to develop red papules and pustules on her face without obvious cause. They were mainly distributed on the forehead, cheeks and mandible, accompanied by pain and occasional itching. She used a variety of acne products on her own, but no significant improvement was seen. She is usually under great work pressure and often stays up late to watch TV series. She prefers to eat spicy and greasy food such as hot pot and barbecue, and has a heavy breath. She denies any history of drug allergies. Current symptoms: densely distributed red papules and pustules can be seen on the forehead, cheeks and mandible, some of which are fused into pieces and painful to touch, the skin is greasy, and the complexion is reddish. The tongue coating is yellow and greasy, and the tip of the tongue is red. The Chinese medicine diagnosis is acne, which is due to heat and toxicity, and the Western medicine diagnosis is common acne. Use the Chinese medicine mask made from Example 6 of the present invention and apply it externally for 20 minutes every day.

[0099] Second visit, July 6, 2024: Current symptoms: Face remains oily, with new papules and papulovesicles and pustules; tongue is red, with a greasy yellow coating. Bad breath. Treatment adjusted: Considering the obvious signs of damp-heat, treatment is based on clearing heat and dampness, cooling blood and detoxifying. The mask ingredients are adjusted to add 20g of Phellodendron amurense and 30g of Isatis indigotica to the formula in Example 6 of the present invention.

[0100] Third visit, August 3, 2024: Current symptoms: No new facial papules, significantly fewer existing pustules, and improved oiliness. Menstrual blood clots have decreased, and menstrual flow has slightly increased. Treatment: Continued topical facial mask application once daily. Recommended to reduce dairy intake, maintain a positive mood, and avoid anxiety and stress.

[0101] Fourth visit, August 14, 2024: Current symptoms: Pustules and papules have largely resolved, leaving only a slight pigmentation, and the greasiness has been significantly reduced. Breath is fresh, bowel movements are normal, and urine is light yellow. The patient was advised to continue maintaining good lifestyle habits and gradually reduce facial mask use to 2-3 times per week to consolidate the therapeutic effect.

[0102] Case 18 The patient is a 19-year-old female. She came to the hospital for treatment on December 5, 2023 because of "recurrent facial papules and pustules for 2 months". In the past 2 months, the patient began to develop red papules and pustules on her face without obvious cause. They are mainly distributed in the forehead, cheeks and mandible, accompanied by pain and occasional itching. She likes to eat sweets and dairy products on a daily basis. She denies a history of drug allergies. Specialist physical examination: Scattered red papules and pustules can be seen on the forehead, cheeks and mandible, some of which have white pus heads and are painful to touch. The tongue is characterized by thick and greasy yellow tongue coating, red tongue edges and tips, and slightly thick sublingual veins. The pulse is slippery and rapid. Traditional Chinese medicine diagnosed it as acne, which is caused by excessive heat in the lungs and stomach, and Western medicine diagnosed it as common acne. Use the Chinese medicine mask made from Example 6 of the present invention and apply it externally for 20 minutes daily.

[0103] On December 26, 2023, the second visit showed that the face still had more oil secretion, a small amount of new papules, papulovesicles and pustules, red skin, dry stool, and dark yellow urine. The TCM signs were red tongue, yellow and greasy fur, and slippery and rapid pulse. Considering that the heat evil in the body was more prevalent, the treatment was to cool the blood and eliminate spots, purge fire and detoxify, and adjust the mask ingredients by adding 15g of Phellodendron chinense and 20g of Isatis indigotica to the prescription in Example 6 of the present invention.

[0104] On January 16, 2024, the patient's third visit revealed the following symptoms: There were essentially no new facial papules, and most of the existing pustules had dried and crusted. Facial oil secretion had decreased, and his complexion had improved. His tongue was thinly coated with a yellow coating and pale red. His pulse was stringy and slippery, but milder than before. He was instructed to continue using the facial mask once daily and to reduce his intake of spicy and greasy foods.

[0105] On February 6, 2024, the patient underwent a fourth visit. Symptoms: Pustules and papules have completely resolved, leaving only a few acne scars. Facial oiliness has largely disappeared, and the skin has returned to smoothness. The tongue is pale red with a thin white coating, and the pulse is normal. It is recommended that the frequency of facial mask use be reduced to 2-3 times per week to consolidate the therapeutic effect.

Claims

1. A traditional Chinese medicine composition for external application for cooling blood and eliminating acne, characterized in that: The composition comprises the following raw materials in parts by weight: 15-20 parts of phellodendron, 15-30 parts of dandelion, 15-30 parts of isatis indigotica, 9-15 parts of viola yedoensis, 9-15 parts of sophora flavescens, 15-30 parts of rhubarb, 9-15 parts of angelica sinensis, and 20-30 parts of trichosanthes.

2. The Chinese medicine composition according to claim 1, wherein The composition comprises the following raw materials in parts by weight: 20 parts of Phellodendron amurense, 30 parts of Taraxacum mongolicum, 25 parts of Isatis indigotica, 12 parts of Viola yedoensis, 12 parts of Sophora flavescens, 15 parts of Rhubarb, 12 parts of Angelica sinensis, and 25 parts of Radix Trichosanthis.

3. The Chinese medicine composition according to claim 1 or claim 2, characterized in that The following raw materials can be added to the composition according to the symptoms: red peony root, salvia miltiorrhiza, chuanxiong, tuckahoe, raw rehmannia, angelica dahurica, white peony root, liquorice, coptis root, forsythia, ophiopogon, with an amount of 9 to 15 parts by weight.

4. Use of the Chinese medicine composition according to any one of claims 1 to 3 in preparing a Chinese medicine facial mask for cooling blood and eliminating acne.

5. A method for preparing a blood-cooling and acne-eliminating Chinese medicine facial mask using the Chinese medicine composition according to any one of claims 1 to 3, characterized in that: The steps include: (1) Medicinal material processing: Wash and dry the raw materials of the Chinese medicinal composition, and grind them into fine powder; (2) Fusion of medicinal properties: the fine powder obtained in step (1) is immersed in deionized water, filtered after soaking to obtain an extract, and then lyophilized after rotary evaporation to prepare a lyophilized powder of traditional Chinese medicine; (3) Stir-frying to enhance efficacy: stir-fry the freeze-dried powder of the Chinese medicine obtained in step (2); (4) Preparation of essence: The stir-fried powder obtained in step (3) was mixed with deionized water at a mass volume ratio of 1:(1-2) (g / mL) and ultrasonicated to obtain a facial mask essence; (5) Film formation: Place the mask base fabric into the mask essence obtained in step (4), and ultrasonicate to obtain a Chinese medicine mask.

6. The preparation method according to claim 5, wherein The fine powder in step (1) is passed through a 110-130 mesh sieve.

7. The preparation method according to claim 5, wherein The soaking in step (2) is: warm soaking at 50-60° C. for 2-3 hours.

8. The preparation method according to claim 5, wherein The stir-frying in step (3) is as follows: stir-frying at 110-130° C. for 10-20 minutes until the medicinal aroma is released.

9. The preparation method according to claim 5, wherein The ultrasonic treatment in step (4) is as follows: ultrasonic treatment in a water bath at 40 to 60° C. for 20 to 40 minutes, with an ultrasonic frequency of 20 to 35 kHz.

10. The preparation method according to claim 5, characterized in that In step (5), the mask base fabric is silk or non-woven fabric; the ultrasound is: 40-60°C water bath ultrasound for 5-15 minutes, and the ultrasound frequency is 1.40-1.94KHz.