Ring type noninvasive blood glucose detector capable of continuously monitoring blood glucose

Abstract

The invention relates to the technical field of medical apparatus and instruments, and discloses a ring-type noninvasive blood glucose detector capable of continuously monitoring blood glucose, comprising a shell sleeving a finger of a wearer; the signal acquisition part is arranged in a shell cavity of the shell, a gap is formed between the detection end of the signal acquisition part extending out of the inner side wall of the shell and the detection part, and the signal acquisition part is used for acquiring biological sign parameters and environmental characteristic parameters of the wearer; the limiting and fixing part is arranged on the shell, the limiting and fixing part and the shell form an annular structure, and the perimeter size of the inner side of the annular structure is adjusted through the limiting and fixing part; the transmission part is arranged in the shell, the biological sign parameters and the environment characteristic parameters of the wearer are calculated through the calculation module, and the calculated result is transmitted to mobile equipment of the wearer through the transmission part. The non-invasive blood glucose detection device realizes non-invasive blood glucose detection, avoids injury to users, is convenient to adjust, adapts to different users, and improves the measurement precision.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to a finger-ring-type non-invasive blood glucose detector capable of continuously monitoring blood glucose. Background Art

[0002] Diabetes is a common, chronic endocrine and metabolic disease with no proven cure. Glucose testing is a key tool for preventing and controlling diabetes. Glucose levels in the human body can be measured using various bodily media, including saliva, tears, sweat, urine, and blood. Blood glucose concentration is the most representative and optimal medium for measuring glucose concentration.

[0003] Currently, the mainstream methods for measuring blood glucose concentration mostly use venous blood draws and fingertip capillary blood draws. The former is mostly used in hospitals and requires professional personnel to operate, while the latter is widely used for individual home testing. Both methods generate medical consumables and cause trauma to the human body. Frequent finger punctures and blood draws affect people's lives and have a certain risk of infection. The testing cost is relatively high, and it is impossible to continuously and in real time detect blood glucose. Non-invasive blood glucose testing technology overcomes the shortcomings of traditional testing methods and can effectively meet the needs of diabetics for real-time and frequent monitoring of blood glucose concentrations. It is the direction of development of blood glucose testing technology. However, current non-invasive blood glucose meters use spectral detection or other photoelectric sensing methods for detection. However, signal interference caused by environmental factors, the accuracy of the measurement site setting, and the portability and ease of use of the blood glucose meter itself all limit its actual application.

[0004] Therefore, there is an urgent need for a ring-type non-invasive blood glucose meter that can continuously monitor blood glucose to solve the above problems. Summary of the Invention

[0005] The purpose of the present invention is to provide a finger-ring type non-invasive blood glucose detector that can continuously monitor blood glucose, so as to solve the problems existing in the above-mentioned prior art.

[0006] To achieve the above-mentioned object, the present invention provides the following solution: The present invention provides a ring-shaped non-invasive blood glucose meter capable of continuously monitoring blood glucose, comprising:

[0007] The housing is mounted on the wearer's finger;

[0008] A signal acquisition component is disposed in the shell cavity of the shell, and a detection end of the signal acquisition component extends from the inner side wall of the shell with a gap provided between the detection portion and the detection portion, and the signal acquisition component is used to collect biological sign parameters of the wearer and environmental characteristic parameters;

[0009] A position-limiting fixture is provided on the housing, wherein the position-limiting fixture and the housing form an annular structure, and the inner circumference of the annular structure is adjusted by the position-limiting fixture;

[0010] The transmission component is arranged in the shell, and calculates the wearer's biological sign parameters and environmental characteristic parameters through the calculation module, and the calculated results are transmitted to the wearer's mobile device through the transmission component.

[0011] According to the present invention, a ring-type non-invasive blood glucose detector that can continuously monitor blood glucose is provided. The signal acquisition component includes a photoplethysmography sensor, a thermal radiation temperature sensor, and an ambient temperature and humidity sensor. The photoplethysmography sensor is used to receive reflected waves to detect the photoplethysmography of a living body, the thermal radiation temperature sensor is used to detect the contact heat and radiation heat of the living body, and the ambient temperature and humidity sensor is used to detect the temperature and humidity around the living body.

[0012] According to a ring-type non-invasive blood glucose detector that can continuously monitor blood glucose provided by the present invention, the limiting fixing part includes a limiting plate, an opening is provided on the shell, the limiting plate is located in the open end and both ends extend into the shell respectively, one end of the limiting plate is fixedly connected to the shell, and the other end of the limiting plate is slidably connected to the shell, the movable end of the limiting plate is fixedly connected to the limiting telescopic rod, a plurality of limiting holes are provided on the shell, and the limiting telescopic rod is adapted to the limiting holes.

[0013] According to a ring-type non-invasive blood glucose meter that can continuously monitor blood glucose provided by the present invention, a groove is provided on the limit plate, the limit telescopic rod is slidably connected in the groove, a spring is provided in the groove, and the two ends of the spring are fixedly connected to the inner wall of the groove and the limit telescopic rod respectively.

[0014] According to the present invention, a ring-type non-invasive blood glucose detector that can continuously monitor blood glucose also includes a power supply module, which is arranged in the shell, and the photoelectric volumetric pulse wave sensor, the thermal radiation temperature sensor, the ambient temperature and humidity sensor and the transmission element are respectively connected to the power supply module.

[0015] According to the present invention, a ring-type non-invasive blood glucose detector capable of continuously monitoring blood glucose is provided, wherein the shell has a charging hole, and the charging hole is connected to the power module.

[0016] According to the present invention, a finger-ring-type non-invasive blood glucose detector capable of continuously monitoring blood glucose is provided, wherein at least one avoidance hole is provided on the inner wall of the shell.

[0017] According to the present invention, a finger-ring-type non-invasive blood glucose detector capable of continuously monitoring blood glucose is provided, wherein the shell is made of polycarbonate.

[0018] According to the present invention, a finger-ring-type non-invasive blood glucose detector capable of continuously monitoring blood glucose is provided, wherein the inner circumference of the ring structure is 50 mm to 61 mm.

[0019] According to the present invention, a finger-ring-type non-invasive blood glucose detector capable of continuously monitoring blood glucose is provided, wherein the gap distance between the detection end of the signal acquisition component and the detection part is 3mm-5mm.

[0020] Compared with the prior art, the present invention has the following advantages and technical effects:

[0021] The present invention provides a ring-shaped, non-invasive blood glucose meter that can continuously monitor blood glucose. The housing is a wearable structure. After being worn, the wearer performs non-invasive blood glucose testing through a signal acquisition component, avoiding harm to the wearer. The detection method uses a combination of thermal and optical methods to shield the interference of external environmental factors on the test to the greatest extent, improving the measurement accuracy of blood glucose. The size of the entire device can be adjusted by the provided limit fixing parts, making it convenient for the wearer to adjust the tightness and adapt to different groups of people. This application realizes non-invasive detection of blood glucose, avoids harm to the user, is easy to adjust, adapts to different users, and improves measurement accuracy. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments. Obviously, the drawings described below are only some embodiments of the present invention. Those skilled in the art can also derive other drawings based on these drawings without inventive work.

[0023] Figure 1 It is a schematic diagram of the overall structure of the present invention;

[0024] Figure 2 This is a schematic diagram of the internal structure of the housing of the present invention;

[0025] Figure 3 This is a schematic diagram of the structure of the position-limiting telescopic rod of the present invention;

[0026] Figure 4 This is a flow chart of the blood glucose concentration calculation method of the present invention:

[0027] Among them, 1. Shell; 2. Signal acquisition component; 21. Photoelectric capacitance pulse wave sensor; 22. Thermal radiation temperature sensor; 23. Ambient temperature and humidity sensor; 3. Limit plate; 31. Limit telescopic rod; 32. Limit hole; 33. Spring; 34. Groove; 4. Transmission component; 5. Power module; 6. Charging port; 7. Avoidance hole. DETAILED DESCRIPTION

[0028] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0029] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and easy to understand, the present invention is further described in detail below with reference to the accompanying drawings and specific embodiments.

[0030] Reference Figures 1-4 The present invention provides a ring-type non-invasive blood glucose detector capable of continuously monitoring blood glucose, comprising:

[0031] Shell 1, which is mounted on the wearer's finger;

[0032] The signal acquisition component 2 is disposed in the shell cavity of the shell 1, and a detection end of the signal acquisition component 2 extends from the inner wall of the shell 1 with a gap provided between the detection portion and the signal acquisition component 2. The signal acquisition component 2 is used to collect biological parameters of the wearer and environmental characteristic parameters;

[0033] A position-limiting fixture is provided on the housing 1. The position-limiting fixture and the housing 1 form an annular structure, and the inner circumference of the annular structure is adjusted by the position-limiting fixture.

[0034] The transmission component 4 is arranged in the housing 1, and calculates the wearer's biological sign parameters and environmental characteristic parameters through the calculation module, and the calculated results are transmitted to the wearer's mobile device through the transmission component 4.

[0035] In one embodiment of the present application, the shell 1 is a wearable structure. After being worn, the signal acquisition component 2 is used to perform non-invasive and non-invasive blood glucose testing on the wearer to avoid causing harm to the user. The size of the entire device is adjusted by the provided limiting fixing parts to facilitate the wearer to adjust the tightness and adapt to different groups of people.

[0036] Specifically, the transmission component 4 includes a main control chip and a Bluetooth module. The Bluetooth transmission module uses the HC-05 module, which is used to transmit the device's real-time power and the final calculated dynamic blood glucose value and related physiological parameter indicators to mobile devices such as mobile phones, so as to facilitate the recording and monitoring of blood glucose.

[0037] As an optional embodiment, the signal acquisition component 2 includes a photoelectric volumetric pulse wave sensor 21, a thermal radiation temperature sensor 22 and an ambient temperature and humidity sensor 23. The photoelectric volumetric pulse wave sensor 21 is used to receive reflected waves to detect the photoelectric volumetric pulse wave of the organism, the thermal radiation temperature sensor 22 is used to detect the contact heat and radiation heat of the organism, and the ambient temperature and humidity sensor 23 is used to detect the temperature and humidity around the organism.

[0038] In one embodiment of the present application, the control chip uses stm32f103c8t6, ​​equipped with AMS1117 voltage regulator chip and other modules for controlling the entire circuit, the photoelectric volume pulse wave sensor 21 can use a reflective dual-wavelength photoelectric biosensor of the type AFE4400, MAX30102, ADPD105, etc., and detects the photoelectric volume pulse wave recording signal of the organism by receiving the reflected wave; the thermal radiation temperature sensor 22 can use a non-contact thermal radiation temperature measurement sensor of the type TMP006, MLX90614, D6T, etc., for detecting The environmental temperature and humidity sensor 23 can use a digital temperature and humidity sensor of the AM2302, BME280, SHT45, AM2320 or other models to detect the temperature and humidity around the measured organism. Based on the contact heat of the measured organism, the radiant heat of the measured organism, the temperature and humidity around the measured organism, and the photoplethysmography signal of the measured organism, the local metabolic rate, arterial oxygen saturation, blood flow velocity and arterial pulse rate of the measured organism are obtained after processing, and then the parameters of the blood glucose concentration of the measured organism are obtained and recorded.

[0039] refer to Figure 4 Specifically, for the photoplethysmography signals collected above, according to photoplethysmography, when light passes through a detection site such as a finger and then reflects back to the detection location, the absorption of light by body tissues such as muscles and bones in motion and static conditions remains essentially unchanged. However, flowing blood absorbs light of different wavelengths to varying degrees as blood oxygen saturation changes. For the two photoplethysmography signals of different wavelengths collected by the photoplethysmography sensor 21, the characteristic blood oxygen saturation SpO2 is extracted and calculated as follows:

[0040]

[0041] Among them, A, B are calibration coefficients, R red , D red are the range and mean of the red light photoplethysmogram, R ir , D ir They are the range and mean of infrared photoplethysmography respectively.

[0042] Since the photoplethysmography signal has the same cycle as the heartbeat, the characteristic pulse rate HR is extracted and calculated as follows:

[0043]

[0044] Where T is the photoplethysmography cycle.

[0045] For the contact heat, radiant heat, and ambient temperature and humidity collected above, according to the energy metabolism conservation theory, the metabolic conservation formula for the detection part in a non-movement state is approximately:

[0046] BMR=Q con +Q eva +Q rad (c)

[0047] Q con =h×(t w -t f ) (d)

[0048] Q eva =rm(P sk -P a ) (e)

[0049] Q rad =εσt w 4 (f)

[0050] Among them, BMR is the direct characteristic local metabolic rate, Q con is the convective heat, Q eva is the heat of vaporization, Q rad is metabolic heat, h is convective heat transfer coefficient, t w and t f are the surface temperature of the measured organism and the ambient temperature, r is the vaporization heat of water, m is the skin permeability coefficient, P sk and P a are the saturated partial pressure of water vapor in the air at skin temperature and humidity and actual ambient temperature and humidity, respectively; ε is the blackness of the measured skin, which can be approximated to 0.964; and σ is the blackbody radiation constant.

[0051] The direct features extracted above, namely, the blood oxygen saturation, heart rate, and local metabolic rate of the measured organism, are used as inputs to the neural network Resnet50, and the blood glucose concentration is used as the prediction label. The training set and the prediction set are divided into a ratio of 7:3 to train the neural network. In actual measurements, the blood oxygen saturation, heart rate, and local metabolic rate are input into the pre-trained model to predict the final blood glucose concentration.

[0052] As an optional embodiment, the limiting fixing part includes a limiting plate 3, an opening is provided on the shell 1, the limiting plate 3 is located in the opening end and both ends extend into the shell 1 respectively, one end of the limiting plate 3 is fixedly connected to the shell 1, and the other end of the limiting plate 3 is slidingly connected to the shell 1, and the movable end of the limiting plate 3 is fixedly connected to the limiting telescopic rod 31, and a plurality of limiting holes 32 are provided on the shell 1, and the limiting telescopic rod 31 is adapted to the limiting holes 32.

[0053] In one embodiment of the present application, the size of the entire annular structure is adjusted by connecting the limiting telescopic rod 31 with different limiting holes 32.

[0054] As an optional embodiment, a groove 34 is provided on the limiting plate 3, and the limiting telescopic rod 31 is slidably connected in the groove 34. A spring 33 is provided in the groove 34, and the two ends of the spring 33 are fixedly connected to the inner wall of the groove 34 and the limiting telescopic rod 31 respectively.

[0055] In one embodiment of the present application, the spring 33 is provided to drive the limiting telescopic rod 31 to be clamped in the limiting hole 32.

[0056] As an optional embodiment, it also includes a power module 5, which is arranged in the shell 1, and the photoelectric volumetric pulse wave sensor 21, the thermal radiation temperature sensor 22, the ambient temperature and humidity sensor 23 and the transmission element 4 are respectively connected to the power module 5.

[0057] In one embodiment of the present application, the power module 5 is preferably an ML2032 rechargeable lithium manganese oxide button battery with an operating voltage between 2.5V and 3.6V. It can be recharged and used repeatedly to power all circuits of the device. The battery is equipped with a protection circuit and a power detection circuit for real-time monitoring of the battery status and feedback of information such as power.

[0058] As an optional embodiment, the housing 1 is provided with a charging hole 6 , which is connected to the power module 5 .

[0059] In one embodiment of the present application, a charging hole 6 is provided to facilitate charging of the power module 5 .

[0060] As an optional embodiment, at least one avoidance hole 7 is opened on the inner wall of the housing 1 .

[0061] In one embodiment of the present application, a avoidance hole 7 is provided on the shell 1 to prevent the shell 1 from being damaged due to plastic deformation during the adjustment of the ring size, thereby increasing the service life of the detection device and having a heat dissipation function to ensure the normal operation of the device.

[0062] As an optional embodiment, the housing 1 is made of polycarbonate.

[0063] In one embodiment of the present application, the shell 1 is made of polycarbonate material through 3D printing, which has the advantages of light weight and high strength.

[0064] As an optional embodiment, the inner circumference of the annular structure is 50 mm-61 mm.

[0065] In one embodiment of the present application, a limiting telescopic rod 31 is provided to extend into different limiting holes 32 to adjust the inner circumference of the entire annular structure to ensure its adaptation range, and at the same time, the gap between the detection end and the detection part of the signal acquisition component 2 can be adjusted.

[0066] As an optional implementation, the gap distance between the detection end of the signal acquisition component 2 and the detection part is 3 mm-5 mm.

[0067] In one embodiment of the present application, the detection end of the signal acquisition component 2 is at a suitable acquisition distance of 3 mm to 5 mm from the detection portion, thereby improving the reading accuracy.

[0068] The present invention provides a finger-ring-type non-invasive blood glucose detector that can continuously monitor blood glucose. The present invention has a finger-ring-type wearable structure, which can complete blood glucose testing only by wearing it, and is relatively convenient to use; the device of the present application is small in size, easy to carry, and can achieve long-term blood glucose monitoring; the non-invasive non-invasive blood glucose detection method can avoid causing harm to the user; the size of the finger ring is adjusted by limiting holes, which is convenient for patients to adjust the tightness, and can be used by different patients; the present application uses a detection method that combines thermal and optical methods to shield the interference of external environmental factors on the test to the greatest extent, improve the measurement accuracy of blood glucose, and with the coordinated work of various modules, can accurately calculate the measurement results and save historical measurement results, which is convenient for real-time viewing of blood glucose concentration and analysis and statistics of later data.

[0069] In the description of the present invention, it should be understood that the terms "longitudinal", "transverse", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", etc., indicating the orientation or position relationship, are based on the orientation or position relationship shown in the accompanying drawings, and are only for the convenience of describing the present invention, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present invention.

[0070] The embodiments described above are merely descriptions of preferred embodiments of the present invention and are not intended to limit the scope of the present invention. Without departing from the spirit of the present invention, various modifications and improvements made to the technical solutions of the present invention by persons skilled in the art should fall within the scope of protection defined by the claims of the present invention.

Claims

1. A ring-type non-invasive blood glucose meter capable of continuously monitoring blood glucose, characterized in that: include: A housing (1) is mounted on a finger of a wearer; A signal acquisition component (2) is arranged in the shell cavity of the shell (1), and a detection end of the signal acquisition component (2) extends from the inner side wall of the shell (1) with a gap provided between the detection portion and the detection portion. The signal acquisition component (2) is used to collect biological sign parameters of the wearer and environmental characteristic parameters; A position-limiting fixture is provided on the housing (1), the position-limiting fixture and the housing (1) forming an annular structure, and the inner perimeter of the annular structure is adjusted by the position-limiting fixture; The transmission element (4) is arranged in the housing (1), and calculates the wearer's biological sign parameters and environmental characteristic parameters through a calculation module, and the calculated results are transmitted to the wearer's mobile device through the transmission element (4).

2. A ring-type non-invasive blood glucose meter capable of continuous blood glucose monitoring according to claim 1, characterized in that: The signal acquisition component (2) comprises a photoplethysmography sensor (21), a thermal radiation temperature sensor (22) and an ambient temperature and humidity sensor (23); the photoplethysmography sensor (21) is used to receive reflected waves to detect the photoplethysmography of a living body; the thermal radiation temperature sensor (22) is used to detect contact heat and radiation heat of the living body; and the ambient temperature and humidity sensor (23) is used to detect the temperature and humidity around the living body.

3. The ring-shaped non-invasive blood glucose meter capable of continuously monitoring blood glucose according to claim 1, characterized in that: The limiting fixing member comprises a limiting plate (3), an opening is provided on the shell (1), the limiting plate (3) is located in the end of the opening and both ends extend into the shell (1), one end of the limiting plate (3) is fixedly connected to the shell (1), and the other end of the limiting plate (3) is slidably connected to the shell (1), the movable end of the limiting plate (3) is fixedly connected to a limiting telescopic rod (31), and a plurality of limiting holes (32) are provided on the shell (1), and the limiting telescopic rod (31) is adapted to the limiting holes (32).

4. A ring-type non-invasive blood glucose meter capable of continuous blood glucose monitoring according to claim 3, characterized in that: The limiting plate (3) is provided with a groove (34), the limiting telescopic rod (31) is slidably connected in the groove (34), a spring (33) is provided in the groove (34), and two ends of the spring (33) are respectively fixedly connected to the inner wall of the groove (34) and the limiting telescopic rod (31).

5. The ring-shaped non-invasive blood glucose meter capable of continuously monitoring blood glucose according to claim 2, characterized in that: It also includes a power module (5), which is arranged in the housing (1); the photoplethysmography sensor (21), the thermal radiation temperature sensor (22), the ambient temperature and humidity sensor (23), and the transmission element (4) are respectively connected to the power module (5).

6. The ring-shaped non-invasive blood glucose meter capable of continuously monitoring blood glucose according to claim 5, characterized in that: The housing (1) is provided with a charging hole (6), and the charging hole (6) is connected to the power module (5).

7. The ring-shaped non-invasive blood glucose meter capable of continuously monitoring blood glucose according to claim 1, characterized in that: At least one avoidance hole (7) is provided on the inner wall of the housing (1).

8. The ring-shaped non-invasive blood glucose meter capable of continuously monitoring blood glucose according to claim 1, characterized in that: The shell (1) is made of polycarbonate.

9. The ring-shaped non-invasive blood glucose meter capable of continuously monitoring blood glucose according to claim 1, characterized in that: The inner circumference of the ring structure is 50mm-61mm.

10. The ring-shaped non-invasive blood glucose meter capable of continuously monitoring blood glucose according to claim 1, characterized in that: The gap distance between the detection end of the signal collecting component (2) and the detection part is 3mm-5mm.

Images