Container assembly and extracorporeal blood treatment machine with container assembly

Abstract

The present disclosure relates to a container assembly for an extracorporeal blood treatment machine or for an extracorporeal blood treatment machine as a substitute for a plug-in container designed with a predetermined topology for providing an alkaline solution, the container assembly having: a container provided and configured to receive an alkaline drying substance, the invention relates to an extracorporeal blood processor comprising a container inlet and a container outlet, an adapter comprising an inlet connection section and an outlet connection section, the inlet connection section being provided and designed to be coupled and fluidically connected to an inlet of a plug-in container receptacle of the extracorporeal blood processor, the outlet connection section is provided and designed at least for coupling to an outlet of a plug-in container receptacle of an extracorporeal blood treatment machine, and a solvent flow path, which is provided and designed to pass through the container from the inlet connection section of the adapter via the container inlet and to the container outlet. In addition, the present disclosure relates to an extracorporeal blood treatment machine having a container assembly.

Description

Technical Field

[0001] The present disclosure relates to a container assembly for preparing and providing an alkaline solution composed of an alkaline dry substance for an extracorporeal blood treatment machine, and to an extracorporeal blood treatment machine, in particular a dialysis machine, for extracorporeal blood treatment, such as hemodialysis, hemofiltration, hemodiafiltration, and / or ultrafiltration. The blood treatment machine comprises a dialyzer having a semipermeable membrane for exchanging substances between a patient's blood, which is guided in an extracorporeal blood circuit, and dialysate of a dialysate circuit, which passes through the dialyzer via a blood input and a blood output. Ultrapure water is mixed with an alkaline dry substance, in particular a bicarbonate dry substance, by a mixing unit of the blood treatment machine, in particular to prevent possible acidosis. An acid concentrate is additionally added to the mixing unit. The fresh dialysate thus prepared is provided to the dialysate circuit. Background Art

[0002] In extracorporeal blood treatment, such as blood purification in the form of hemodialysis, hemofiltration, or hemodiafiltration, blood is removed from the dialysis patient via an arterial access port and transported via an extracorporeal blood circuit to a dialyzer for blood treatment. Fresh dialysate, prepared as needed, is also supplied to the dialyzer via a dialysate circuit. To prepare the fresh dialysate, ultrapure water is provided by a water preparation unit, particularly a reverse osmosis system, degassed, and then mixed with an alkaline dry substance and an acid concentrate in a mixing unit. Bicarbonate, for example, is used as the alkaline dry substance. In intermittent or outpatient blood treatment, particularly in the treatment of chronic renal insufficiency, bicarbonate is provided in an insertable container having predetermined dimensions and connection topology coordinated with the blood treatment machine. The blood treatment machine is provided with an insertable container receptacle of predetermined dimensions and connection topology. The insertable container is inserted into this specially adapted insertable container receptacle. The sensor system detects whether both connections of the insertable container receptacle, namely the inlet connection and the outlet connection, are actually coupled to the receptacle and fluidically connected, with ultrapure water being present at the inlet connection and the mixed bicarbonate solution being available at the outlet connection. This verifies whether the insertable container receptacle is actually occupied by the intended insertable container and that the necessary fluid connections of the inlet and outlet are correctly configured, so that the dissolution of the bicarbonate dry substance can proceed reliably and in accordance with the regulations. If it is detected that the insertable container receptacle is correctly occupied, the control unit authorizes the mixing operation, which itself is a prerequisite for blood treatment.

[0003] Conventional insert containers, such as those owned by the applicant and named Sol- B known bicarbonate cartridge or the name The known concentrate bags contain a relatively small amount of dry substance and only support a single blood treatment.

[0004] A disadvantage of these solutions is that the small quantities necessitate frequent repackaging / replacement of the insertable containers. Furthermore, these insertable containers are intended only for single use, and any unneeded excess must be discarded. Consequently, the material investment in primary packaging material, especially the plastic used for the insertable containers, such as PET, PE, or PP, is high, which negatively impacts environmental compatibility / balance. Summary of the Invention

[0005] In contrast, the task of the present disclosure is to avoid or at least reduce the disadvantages of the prior art and in particular to provide a container assembly and an extracorporeal blood treatment machine which provide for more efficient and safe, intermittent or ambulatory extracorporeal blood treatment.

[0006] According to the present disclosure, the object of the present disclosure is achieved with respect to the container assembly and according to the present disclosure, the object of the present disclosure is achieved with respect to the extracorporeal blood treatment machine.

[0007] The basic concept of the present disclosure provides that, in order to provide an alkaline dry substance and to prepare and provide an alkaline solution, an adapter designed to adapt to the topology is inserted, mechanically coupled, and fluidically connected to an insertable container receptacle of an extracorporeal blood treatment machine, which is designed with a predetermined mechanical and fluidic connection topology, instead of a insertable container designed according to the predetermined topology. The adapter has smaller dimensions than the predetermined insertable container. According to the present disclosure, a container containing the alkaline dry substance, designed independently of the topology of the insertable container receptacle, is fluidically connected to the adapter. In particular, the container can be located remotely from the insertable container receptacle on the extracorporeal blood treatment machine.

[0008] The resulting advantage is that at least the solvent inlet and preferably also the solution outlet of the insertable container receptacle of the blood treatment machine can be used by the adapter to deliver solvent / ultrapure water and preferably to provide alkaline solution, and the amount of dry substance provided by the container is no longer limited to a relatively small amount of pre-designed insertable containers. Preferably, the container of the container assembly according to the present disclosure is designed and configured, particularly in terms of its material and internal volume, for multiple blood treatments. Thus, using a container that preferably contains more dry substance than the pre-designed insertable container, multiple blood treatments can be performed sequentially in the same blood treatment machine, or, in other words, continuously without replacing the container. Consequently, compared to a pre-designed, relatively small insertable container, a relatively large container fluidically connected via the adapter does not need to be replaced as frequently. This reduces the effort during blood treatment and reduces manufacturing costs, as fewer containers / container material are required for the pre-designed amount of dry substance. Furthermore, unlike insertable containers designed for single use, residual quantities are not regularly discarded. Of course, as an alternative to the disclosed solution, the insertable container receptacle can be used continuously with the pre-designed insertable container for a single use.

[0009] In other words, the present disclosure is based on the concept of providing, for existing / known extracorporeal blood treatment machines, an adapter having the same predetermined connection topology and connection dimensions, in particular with respect to the amount of dry substance contained and its connection topology and connection dimensions, in particular the topology and dimensions of its fluid inlet and outlet, instead of a predetermined plug-in container (which is predetermined in particular with respect to the amount of dry substance contained and its connection topology and connection dimensions, in particular the topology and dimensions of its fluid inlet and outlet), and fluidically connecting a container to the adapter, which preferably contains a larger amount of dry substance than the predetermined plug-in container. The adapter according to the present disclosure is preferably configured and designed to be inserted into a predetermined plug-in container receptacle of an existing / known extracorporeal blood treatment machine, which is designed for a predetermined plug-in container. Thus, according to the present disclosure, on the one hand, a solvent, preferably ultrapure water, can be provided via the predetermined plug-in container receptacle, and on the other hand, a container containing dry substance, which can be freely selected in terms of its contained amount, its connection topology, and its dimensions, in particular the topology and dimensions of its fluid inlet and outlet, can be connected / used.

[0010] In other words, the present disclosure provides a container assembly for an extracorporeal blood treatment machine or an extracorporeal blood treatment machine, which is configured and designed for intermittent or outpatient blood treatment. The container assembly according to the present disclosure is configured and designed as an alternative to insertable containers with a predetermined topology for providing an alkaline dry substance, for dissolving the dry substance, and for providing the resulting alkaline solution, in particular a bicarbonate solution. To this end, the container assembly has:

[0011] a container, which is arranged and configured to receive an alkaline dry substance, to be in contact with a solvent and to provide an alkaline solution, wherein the container has a container inlet and a container outlet, the container inlet being arranged and configured to be fluidically connected to a solvent inlet of a blood treatment machine, and the container outlet being arranged and configured to provide the alkaline solution, in particular to a dialysate circuit of an extracorporeal blood treatment machine;

[0012] An adapter, in particular a fluid adapter, is provided and constructed to be inserted into a predetermined designed insertable container receptacle of an extracorporeal blood treatment machine as a replacement for an insertable container. The insertable container receptacle is preferably provided and predeterminedly designed to be coupled to and fluidically connected to the insertable container. To this end, the insertable container receptacle preferably has an inlet that can be fluidically connected, in particular already connected, to the solvent inlet of the extracorporeal blood treatment machine and an outlet that can be fluidically connected, in particular already connected, to the dialysate circuit of the extracorporeal blood treatment machine. The inlet and outlet of the insertable container receptacle are preferably arranged and constructed in a predetermined manner relative to one another. In particular, the inlet and outlet are pre-arranged and constructed relative to one another according to a predetermined topological structure of the insertable container. According to the present disclosure, the adapter comprises an inlet connection section and an outlet connection section, the inlet connection section being provided and designed for coupling and fluidically connecting to the inlet of the insertable container receptacle of the extracorporeal blood treatment machine, and the outlet connection section being provided and designed for coupling at least to the outlet of the insertable container receptacle of the extracorporeal blood treatment machine, that is, for positioning and / or fastening, but not necessarily also for fluid connection;

[0013] At least one solvent flow path, preferably a solvent line and / or a solvent hose, is provided and can be configured to lead from the inlet connection section of the adapter via the container inlet, through the container and to the container outlet.

[0014] As mentioned above, with the aid of the container assembly according to the present disclosure, it is possible to use the predetermined design of the plug-in container receiving portion of the extracorporeal blood treatment machine to fluidically connect a container that does not meet / needs to meet the predetermined plug-in container topology. Therefore, with the aid of the container assembly according to the present disclosure, different containers with different topologies, especially different connection topologies, can be coupled and fluidically connected with the plug-in container receiving portion. The reason for this is that the container is not inserted into and coupled to the plug-in container receiving portion, but the adapter of the container assembly is inserted into and coupled to the plug-in container receiving portion, and the adapter has the topology, especially the connection topology, required by the plug-in container assembly. Therefore, containers of any topology and any amount of content can be fluidically connected. As mentioned above, the predetermined plug-in container is determined to be disposable. The unwanted residual amount of the contained dry matter must always be discarded. Utilizing the container assembly according to the present disclosure, even a large reservoir containing significantly more dry matter than the predetermined plug-in container can be connected as a container. This, in turn, allows the use of predefined plug-in containers on extracorporeal blood treatment machines with containers of any size and topology, allowing the connected container to be used throughout a single blood treatment / dialysis treatment. Frequent refitting / replacement, which is necessary when using relatively small predefined plug-in containers regardless of their remaining fill level after each treatment, is reduced or no longer necessary. Thus, with the container assembly according to the present disclosure, multiple uses are possible when the container is selected to be appropriately large, for example, with a content exceeding one liter, particularly two to five liters of dry substance, and the contents can be used in multiple blood treatments. Excess volume from the first blood treatment can thus be used in subsequent blood treatments and does not need to be discarded. A new container with alkaline dry substance must be connected to the adapter only after the dry substance in the container has been consumed. This significantly reduces the amount of primary packaging material, particularly the plastic material used for the container, such as PET, PE, or PP. This also significantly improves the environmental compatibility / balance of the product.

[0015] In short, according to the present disclosure, a container assembly for providing alkaline dry substances and solutions thereof is provided, by which intermittent or outpatient extracorporeal blood treatment can be performed more efficiently and safely.

[0016] Preferably, the amount of the container / contained dry matter is determined to enable the blood treatment machine to continuously process blood within a week. Here, the volume of the container / contained dry matter amount is greater than one liter, in particular 1.5 to 5 liters.

[0017] Since the container does not have to be (anymore) fitted topologically into a predetermined plug-in container receptacle, the container is preferably optimized in terms of its storage capacity and / or its transport. Preferably, the container has a rectangular, in particular stackable, basic shape.

[0018] For dynamic multiple applications during dialysis treatment, the alkaline dry substance is preferably a pharmaceutical solid concentrate, preferably a bicarbonate-based dialysis concentrate, preferably sodium bicarbonate.

[0019] According to a possible refinement of the container assembly, a first supply flow path is provided, originating from the container outlet and bypassing the outlet connector of the adapter, for supplying the alkaline solution prepared by dissolving the dry substance in the container to the dialysate circuit of the extracorporeal blood treatment machine. This allows the container outlet to be connected independently of the outlet connector of the adapter and, therefore, the outlet of the plug-in container receptacle. This allows, for example, very flexible supply to the solution container.

[0020] Preferably, the first provided flow path opens / ends at an extraction lance which is insertable / immersible into a solution container of an extracorporeal blood treatment machine.

[0021] In an alternative or additional development of the container assembly, a second supply flow path is provided, which runs from the container outlet to the outlet connector of the adapter, in order to supply the alkaline solution prepared by dissolving a dry substance in the container to the dialysate circuit of the extracorporeal blood treatment machine. In this way, the container outlet can be connected via the outlet connector of the adapter and using the outlet of the pluggable container receptacle. Thus, the supply can be achieved via a predetermined fluid connection of the outlet of the pluggable container receptacle of the extracorporeal blood treatment machine.

[0022] According to a preferred embodiment, the container assembly has a preferably switchable bypass flow path, which, while bypassing the container, is arranged to lead from the solvent connection of the adapter to the outlet connection of the adapter. The bypass flow path preferably extends within the adapter, preferably as a hose connection or a tube connection. In this way, the container of the container assembly containing the dry substance can be switched to the bypass or bypass at any time, and the adapter allows the sterilization of the lines and hoses of the extracorporeal blood treatment machine without having to remove or disassemble the container. Although the container preferably contains a large amount of dry substance, it can be sterilized at any time without having to remove or disassemble the container.

[0023] To enable switching at least the aforementioned solvent flow path, the container assembly, in a preferred embodiment, includes a first directional valve with switching positions downstream of the inlet connection section. The solvent flow path is controlled to be open in the first switching position of the first directional valve and blocked in the second switching position of the first directional valve. In the simplest embodiment, the first directional valve is designed as a manually operable 2 / 2-way valve having two connections and two switching positions, one of which is fluidically connected to the inlet connection section and the other to the container inlet.

[0024] To enable switching of the aforementioned second supply flow path via the container outlet to the outlet connection section of the adapter, the container assembly, in a preferred embodiment, includes a second directional valve with switching positions upstream of the outlet connection section of the adapter. The second supply flow path is controlled to be open in the first switching position of the second directional valve and blocked in the second switching position of the second directional valve. In the simplest embodiment, the second directional valve is also designed as a manually operable 2 / 2-way valve having two connections and two switching positions, one of which is fluidically connected to the container outlet and the other to the outlet connection section of the adapter.

[0025] In the case of a refinement with a bypass flow path, this bypass flow path can preferably be switched by means of a first and a second directional valve. Preferably, the bypass flow path is blocked in the first switching position of the two directional valves and is controlled to be open in the second switching position of the two directional valves. In this case, the directional valves are preferably designed as manually actuable 3 / 2-way valves with three connections and two switching positions in a simple embodiment. The 3 / 2-way valves have the same connections and connections as the two 2 / 2-way valves described above, but in addition each has a third connection, wherein the third connections are connected to each other via the bypass flow path.

[0026] The solvent flow paths can be guided differently within the container, which leads to different structural or basic designs of the container.

[0027] According to a first embodiment of the container, both the container inlet (at which the solvent inlet is provided) and the container outlet (at which the alkaline solution outlet is provided) are located at the highest point or highest region of the container. To this end, a dip tube extends from the container outlet into the container and merges into the lowest point or lowest region of the container. The dip tube preferably has a filter at this confluence to prevent the entry of undissolved dry matter. Thus, the solvent enters the container from above, flows through / penetrates the dry matter, and dissolves it. As a result, at the lowest point or lowest region of the container, the alkaline solution enters the dip tube and is expelled to the container outlet, particularly due to continuous replenishment of the solvent.

[0028] In an alternative embodiment, the container inlet is arranged at the highest point or highest region of the container, and the container outlet is arranged at the edge of the container. In this case, the immersion tube also extends from the container outlet into the container and opens at the lowest point or lowest region of the container. In this case, the inlet of the immersion tube preferably has a filter to prevent undissolved dry matter from entering the immersion tube.

[0029] In an alternative design, the container inlet is arranged on the highest point or the highest region of the container, and the container outlet is arranged on the lowest point or the lowest region of the container. In this case, a filter is preferably provided upstream of the container outlet to prevent the undissolved dry matter from flowing out.

[0030] According to the present disclosure, an extracorporeal blood treatment machine, in particular a dialysis machine, is provided and constructed for intermittent or outpatient extracorporeal blood treatment of patient blood. The extracorporeal blood treatment machine according to the present disclosure has:

[0031] dialyzer;

[0032] a dialysate circuit that passes through the dialyzer via a dialysate input and a dialysate output of the dialyzer;

[0033] a mixing unit configured and adapted to mix / dissolve at least ultrapure water and an alkaline dry substance, preferably a bicarbonate dry substance, preferably sodium bicarbonate, to form an alkaline solution and to supply the alkaline solution to the dialysate circuit;

[0034] a plug-in container receptacle of a mixing unit, the plug-in container receptacle being designed according to at least one aspect of the preceding description and being provided and designed for coupling and fluid connection to a plug-in container having a predetermined topology for providing an alkaline solution, wherein the plug-in container receptacle has an inlet and an outlet, the inlet being fluidically connectable, in particular connected, to a solvent inlet of an extracorporeal blood treatment machine, and the outlet being fluidically connectable, in particular connected, to a dialysate circuit for providing an alkaline solution. The inlet and outlet of the plug-in container receptacle are arranged and configured in a predetermined manner relative to one another, in particular according to the predetermined topology of the plug-in container to be received by the plug-in container receptacle according to the present disclosure;

[0035] A container assembly, a container assembly constructed according to the present disclosure according to at least one aspect of the aforementioned description, wherein an adapter of the container assembly is preferably inserted into the insertable container receptacle instead of the predetermined insertable container, the inlet connecting section of the adapter is coupled to the inlet of the insertable container receptacle and is fluidically connected, and the outlet connecting section of the adapter is coupled to at least the outlet of the insertable container receptacle, and wherein at least the solvent flow path is provided and can be constructed, in particular constructed to flow from the inlet connecting section of the adapter via the container inlet of the container, through the container and to the container outlet.

[0036] The advantages of the extracorporeal blood treatment machine according to the present disclosure are discussed in detail during the description of the container assembly designed according to the present disclosure. Therefore, reference is made to the above description of the advantages to avoid undue complexity in this document. In short, the present disclosure provides an extracorporeal blood treatment machine for intermittent or outpatient extracorporeal blood treatment, which enables more efficient and safe blood treatment.

[0037] According to a preferred embodiment, the extracorporeal blood treatment machine comprises a detection unit, in particular a sensor unit, which is suitable for detecting at least whether the coupling of the inlet connection section of the adapter to the inlet of the pluggable container receptacle and the coupling of the outlet connection section of the adapter to the outlet of the pluggable container receptacle are established. In other words, the detection unit can at least detect whether the adapter has been correctly inserted into the pluggable container receptacle. The detection unit is suitable for outputting a signal depending on the detection result, wherein a control unit of the blood treatment machine, signal-connected to the detection unit, is configured and adapted to control the opening of the fluid connection between the solvent inlet and the inlet of the pluggable container receptacle only when it is detected that at least two couplings are established, and to block the fluid connection only when it is detected that only one of the couplings or none of the couplings is established.

[0038] The controlled opening / closing of the fluid connection of the solvent inlet to the inlet of the insertable container receptacle is preferably achieved by actuating a shut-off valve arranged between the solvent inlet and the inlet.

[0039] Particularly preferably, the detection unit is additionally suitable for detecting whether a fluid connection is formed between at least the inlet connecting section of the adapter and the inlet of the insertable container receptacle.

[0040] Alternatively or in addition, at least the inlet connecting section and preferably also the outlet connecting section are designed in such a way that, when correctly coupled to the inlet of the plug-in container receptacle, they automatically correctly establish the fluid connection there, for example by the inlet connecting section and / or the outlet connecting section pushing open or controlling the opening of a non-return valve there when coupled to the inlet and / or outlet, and thus the fluid connection is automatically established upon insertion of the adapter.

[0041] According to a preferred embodiment of the extracorporeal blood treatment machine, a first supply flow path, which originates from the container outlet and leads to the dialysate circuit while bypassing the outlet connection section of the adapter, is provided and can be configured, in particular, configured, for supplying alkaline solution to the dialysate circuit. For this purpose, the container outlet is preferably connected by means of a line or a hose to a withdrawal lance, which is in particular inserted or immersed in a solution container of the extracorporeal blood treatment machine, which is provided for receiving and supplying the solution.

[0042] According to a preferred alternative or supplementary development of the extracorporeal blood treatment machine, a second supply flow path is provided and can be configured, in particular configured, for supplying alkaline solution to the dialysate circuit, starting from the container outlet via the outlet connecting section of the adapter, the outlet of the plug-in container receptacle, and leading to the dialysate circuit. For this purpose, the container outlet is preferably fluidically connected to the outlet connecting section of the adapter via a line or a hose. Preferably, in the second supply flow path, the outlet connecting section of the adapter is not only coupled to the outlet of the plug-in container receptacle, but is also fluidically connected, so that alkaline solution is supplied to the dialysate circuit via this outlet.

[0043] As already mentioned above, according to a development of the extracorporeal blood treatment machine, a bypass flow path is preferably provided and can be formed, in particular formed, from the inlet connecting section of the adapter around the container to the outlet connecting section of the adapter.

[0044] Preferably, as described above, according to an improved scheme of the extracorporeal blood treatment machine, a first reversing valve having a switching position is arranged downstream of the inlet connection section of the adapter, wherein the solvent flow path is controlled to be open in the first switching position of the first reversing valve and is blocked in the second switching position of the first reversing valve.

[0045] Preferably, as described above, according to an improved scheme of the extracorporeal blood treatment machine, a second reversing valve having a switching position is arranged upstream of the outlet connection section of the adapter, wherein the second supply flow path is controlled to be opened in the first switching position of the second reversing valve and is blocked in the second switching position of the second reversing valve.

[0046] As already explained above, according to a development of the extracorporeal blood treatment machine, the bypass flow path is preferably blocked with a first switching position of the first and second directional valves and is controlled to be open with a second switching position of the first and second directional valves. BRIEF DESCRIPTION OF THE DRAWINGS

[0047] The present disclosure will be explained in more detail below based on preferred embodiments with the aid of the accompanying drawings.

[0048] Figure 1A schematic fluid circuit diagram of an extracorporeal blood treatment machine according to a preferred embodiment is shown;

[0049] Figure 2 Show according to the Figure 1 The container assembly of the first embodiment of the extracorporeal blood treatment machine;

[0050] Figure 3 A container assembly according to a second embodiment is shown, which is mounted on a container according to Figure 1 In an extracorporeal blood processing machine;

[0051] Figure 4 Show according to the Figure 1 A container assembly of a third embodiment of an extracorporeal blood treatment machine;

[0052] Figure 5 Shows the basis for bypass switching Figure 4 The container component of

[0053] Figures 6 to 8 Three containers of a container assembly according to three embodiments are shown.

[0054] Wherein: 1 - extracorporeal blood treatment machine; 2 - dialyzer; 2.1 - dialysate input; 2.2 - dialysate output; 2.3 - blood input; 2.4 - blood output; 2.5 - semipermeable membrane; 3 - extracorporeal blood circuit; 4 - dialysate inlet; 5 - dialysate circuit; 6 - mixing unit; 8 - container for alkaline solution; 10 - container for acidic solution; 12 - first delivery device; 14 - second delivery device; 16 - first measuring device; 18 - second measuring device; 20 - solvent Inlet / ultrapure water inlet; 22-transport device; 24-balancing device; 26-first valve; 28-dialysate outlet; 30-treatment output; 32-detection unit; 34-second valve; 38-bypass flow path (dialysate circuit); 40-third valve; 41-arterial hose clamp; 42-arterial hose section; 43-venous hose clamp; 44-blood component sensor; 46-blood pump; 48-blood input pressure sensor; 50-venous hose section; 52-blood flow output pressure sensor Force sensor; 54 - control unit; 56 - memory; 58, 158, 258 - container assembly; 60 - container for alkaline dry substance; 62 - container inlet; 64 - container outlet; 66, 166, 266 - adapter; 68 - inlet; 70 - inlet connecting section; 72 - outlet; 74 - outlet connecting section; 76, 78 - detection unit; 80 - stop valve; 82 - solvent flow path; 84 - first supply flow path; 86 - second supply flow path; 88 - bypass Flow path; 90, 190 - first reversing valve; 92, 192 - second reversing valve; 94 - stop valve; 96 - check valve; 98 - check valve; 100 - providing path; 102 - filter; 104 - delivery device; 106 - providing path; 108 - stop valve; 110 - filter; 112 - nozzle; 114 - screw cap; 116 - hollow part; 118 - scale; 120 - immersion tube; 122 - filter; 124 - immersion tube; P - patient; S - shunt.

[0055] The accompanying drawings are schematic in nature and are intended only for understanding the present disclosure. Identical elements are provided with identical reference numerals. Features of different embodiments may be interchanged with one another. DETAILED DESCRIPTION

[0056] Figure 1 A schematic diagram shows a fluid circuit diagram of an extracorporeal blood treatment machine 1 (hereinafter simply referred to as blood treatment machine) in the form of a dialysis machine for intermittent, in particular outpatient, extracorporeal blood treatment of the blood of a patient P according to a preferred embodiment of the present disclosure.

[0057] In particular, the design and use of a container assembly 58 of a blood treatment machine 1 according to the present disclosure are described, with the aid of which an alkaline dry substance is provided for intermittent, in particular outpatient, extracorporeal blood treatment, placed in solution, and the alkaline solution prepared in this way is provided to the dialysate circuit 5 of the blood treatment machine 1.

[0058] According to the present disclosure, at least the provision and dissolution of the alkaline dry substance and the provision of the alkaline solution to the blood treatment machine 1 are not performed centrally, but rather on the blood treatment machine 1 itself. In contrast, the preparation and dissolution of acidic, salty, or other dry substances and the provision of the corresponding solutions to the blood treatment machine 1 can be performed very centrally, for example, in a larger mixing unit for multiple blood treatment machines 1. This is particularly due to the fact that, for example, acidic solutions are inherently antimicrobial and can be maintained in large quantities and, therefore, for longer periods of time. In contrast, alkaline solutions are maintained in smaller quantities and in a timely manner for extracorporeal blood treatment, resulting in the aforementioned "decentralized" provision of smaller quantities.

[0059] Blood processing machine 1 according to Figure 1 The central component comprises a dialyzer 2, which has, on the one hand, a dialysate inlet 2.1 and a dialysate outlet 2.2 on the dialysate side, and, on the other hand, a blood inlet 2.3 and a blood outlet 2.4 on the blood side of an extracorporeal blood circuit 3. Internally, the dialyzer 2 is divided into a dialysate side and a blood side by means of a hollow fiber semipermeable membrane 2.5.

[0060] The dialysate input 2.1 is fluidically connectable, in particular connected, to a mixing unit 6 via a dialysate inlet 4. The mixing unit continuously prepares fresh dialysate from at least partially evaporated ultrapure water and alkaline dry substances and acid concentrates.

[0061] As an alternative to providing an alkaline concentrate and an acidic concentrate, the mixing unit 6 has a first and a second solution container 8, 10, in which the finished alkaline solution and the finished acidic solution are respectively held, as well as a first and a second conveying device 12, 14, and downstream of the conveying device 12, 14, a first and a second measuring device 16, 18, respectively.

[0062] according to Figure 1The blood treatment machine 1 has a solvent / ultrapure water inlet 20, to which at least partially degassed ultrapure water is continuously supplied from an internal degassing unit (not shown). The ultrapure water inlet 20 can be fluidically connected, in particular connected, to the measuring devices 16, 18, the conveying device 22, and the balancing device 24 arranged in series downstream via a shutoff valve 94, which is signal-connected to the control unit 54 of the blood treatment machine 1. On the output side, the balancing device 24 can be fluidically connected, in particular connected, to the dialysate input 2.1 of the dialyzer 2 via a dialysate inlet 4. A valve 26 for shutting off the dialysate input 2.1 is arranged in the dialysate inlet 4.

[0063] The dialysate outlet 2.2 is fluidically connectable, in particular, connected, to a disposal outlet 30 for used dialysate / dialysate via a dialysate outlet 28. Disposed fluidically in series between the dialysate outlet 2.2 and the disposal outlet 30 are a controllable valve 34 for shutting off the dialysate outlet 2.2, a detection unit 32 for detecting components in the dialysate, and a fourth conveying device 36, via which the dialysate is conveyed to the balancing device 24 and the dialysate disposal outlet 30. The balancing device 24 ensures that the desired volume of excess water can be removed from the patient's blood within the context of ultrafiltration using an ultrafiltration pump. A pressure detection unit 35 is provided in the dialysate outlet 28 upstream of the fourth conveying device 36 for detecting the dialysate outlet pressure.

[0064] In addition, a bypass flow path 38 is provided, via which the dialysate inlet 4 can be fluidically connected to the dialysate outlet 28. An actuatable valve 40 is arranged in the bypass flow path 38, via which the bypass flow path 38 can be blocked.

[0065] On the blood side, an extracorporeal blood circuit 3 is provided, which allows blood to be removed from a patient P via an arterial hose section 42 and supplied to the dialyzer 2 via a blood inlet 2.3. An arterial hose clamp 41, an arterial hematocrit sensor or HCT sensor 44, a blood pump 46, and a blood inlet pressure sensor 48 are arranged in the arterial hose section 42 along the flow direction. After the blood of the patient P is conducted through the blood side of the dialyzer 2 in the extracorporeal blood circuit 3, it is withdrawn at the dialyzer's blood outlet 2.4 and supplied to a shunt S via a venous hose section 50. A blood outlet pressure sensor 52 and a venous hose clamp 43 are arranged in the venous hose section 50. In the dialyzer 2, the blood is conducted in countercurrent to the dialysate, where urinary components and excess water are removed and the blood is then returned / returned to the patient P in a purified state.

[0066] according to Figure 1According to the present disclosure, the extracorporeal blood treatment machine 1 has a container assembly 58 for preparing and providing alkaline solution to the dialysate circuit 5. The container assembly 58 according to the present disclosure can be provided with a finished / premixed alkaline solution as a supplement or alternative to the container 8.

[0067] An inlet path branches off from the ultrapure water inlet 20 upstream of the shutoff valve 94. A shutoff valve 80, which is signal-connected to a control unit and can be actuated, is arranged in this inlet path. A spring-loaded, closed check valve 96, which is spring-loaded and closes in the direction of flow, is arranged downstream of this shutoff valve. The inlet path ends in the receptacle 68 of the plug-in container receptacles 68, 72 of the mixing unit 6. Diametrically opposed to the receptacle 68, the plug-in container receptacles 68, 72 have an outlet 72. A check valve 98 is arranged at this outlet in a mirror-image arrangement and, correspondingly, with an opposite closing direction and spring loading.

[0068] A supply path 100 is provided at the outlet 72 of the insertable container receptacles 68 , 72 , which opens into the flow path from the ultrapure water inlet 20 downstream of the shutoff valve 94 and upstream of the first measuring device 16 via a filter 102 and a controllable delivery device 104 , which is signal-connected to the control unit 54 .

[0069] A supply path 106 originating from the container 8 , from which the finished / premixed alkaline solution can be supplied, extends via a controllable shutoff valve 108 , which is signal-connected to the control unit 54 , and opens into the inlet path between the shutoff valve 80 and the non-return valve 96 .

[0070] according to Figure 1 The container assembly 58 according to the present disclosure has as a first component an adapter 66 having an inlet connection section 70 and an outlet connection section 74. The container assembly has as a second component a container 60 containing an alkaline dry substance having a container inlet 62 and a container outlet 64. Figure 4 In the illustration in FIG, the solvent is already present in the container 60, and the solvent (as will be described below) is supplied to the insertable container receiving portion 68, 72 via the inlet 68. In addition, according to the present disclosure Figure 1 The container assembly 58 has a solvent flow path 82, via which the inlet connecting section 70 of the adapter 66 is fluidically connected to the container inlet 62. A manually actuatable first switching valve 90 designed as a 2 / 2-way valve is arranged in the solvent flow path 82, via which the container inlet 62 can be fluidically connected or disconnected from the inlet connecting section 70 of the adapter 66, depending on the switching position.

[0071] The solvent flow path 82 extends beyond the container inlet 62, the container 60 and the dry matter / solution therein to the container outlet 64, to which a filter 110 is connected upstream for retaining undissolved dry matter.

[0072] The container outlet 64 can be fluidically connected, in particular already connected, to the outlet connection section 74 of the adapter 66 via a second supply path 86, wherein, in the second supply path 86, in particular similar to the first section of the solvent flow path 82 from the inlet connection section 70 to the container inlet, a manually operable second reversing valve 90 designed as a 2 / 2 reversing valve is arranged, through which the container outlet 64 and the outlet connection section 74 of the adapter 66 can be fluidically connected or separated depending on the switching position.

[0073] according to Figure 1 The container assembly, consisting of the adapter 66, the container 60, the solvent flow path 82, the second supply path 86, and the two reversing valves 90, 92, is connected to the plug-in container receptacles 68, 72 as specified. This means that the connecting sections 70, 74 of the adapter 66 are correctly coupled to the respective receptacles 68, 72 assigned thereto. Whether the coupling is correctly configured is detected by detection units 76, 78, which are signal-connected to the control unit 54, and reported to the control unit 54. In particular, it reports whether both connecting sections 70, 74 are actually correctly coupled to the respective receptacles 68, 72, or whether they are coupled to only one receptacle or neither receptacle. The detection units 76, 78 can, for example, be formed by light barriers or contact switches on each individual receptacle 68, 72, which transmit corresponding signals to the control unit 54 when the connecting sections 70, 74 are correctly coupled.

[0074] The plug-in container receptacles 68 , 72 of the blood treatment machine 1 according to the present disclosure have a predetermined connection topology, ie a predetermined arrangement of the inlet receptacle 68 relative to the outlet receptacle 72 and preferably predetermined dimensions of the inlet receptacle 68 and the outlet receptacle 72 .

[0075] In this way, the blood treatment machine is prepared to receive a specific / predetermined plug-in container (not shown) of alkaline dry substance corresponding to the predetermined connection topology as a matching part, coupled and fluidically connected to the inlet 68 and the outlet 72, respectively. The predetermined connection topology of the plug-in container receptacle 58 has the advantage that no container can be received, coupled, and fluidically connected in the plug-in container receptacle 58 as a matching part, which container does not meet or does not correspond to the predetermined connection topology of the plug-in container receptacle 58.

[0076] On the contrary, of course, only a specific / predetermined plug-in container, that is, a plug-in container with its predetermined connection topology, can be inserted, coupled, and fluidically connected into the plug-in container receptacle, and no other plug-in container receiver with a different connection topology can be inserted, coupled, and fluidically connected into the plug-in container receptacle.

[0077] Both of these mean that confusion is ruled out.

[0078] However, this results in the available, specific, pre-defined insert containers for alkaline dry substances being relatively small in size and containing correspondingly small amounts of dry substance. This quantity is optimized for single-use blood treatments, also covering long-term blood treatments, and therefore, a relatively small quantity is provided that is rarely completely used up. The insert containers are accordingly designed for single-use or "single-use" products. This is associated with frequent replacement, the amount of waste generated with almost every replacement, and the large amount of plastic waste generated by the resulting packaging material.

[0079] In order to eliminate or alleviate these disadvantages, the container assembly according to the present disclosure provides an adapter 66 having a topology, in particular an inlet connecting section 70 and an outlet connecting section 72 , adapted to the connection topology of the plug-in container receptacles 68 , 72 .

[0080] Thus, when the adapter 66 is inserted into the plug-in container receptacles 68, 72, the inlet connecting section 70 fits precisely into the inlet 68 and pushes open the non-return valve 96 there, and the outlet connecting section 74 fits precisely into the outlet 72 and pushes open the non-return valve 98 there. Accordingly, the inlet connecting section 70 is coupled to the inlet 68 and the outlet connecting section 74 is coupled to the outlet 72 and fluidically connected.

[0081] This state is reported by detection units 76, 78 to control unit 54, so that shutoff valve 80 can be opened and shutoff valve 94 can be closed by the control unit. In this way, ultrapure water is present at the first switching valve of container assembly 58. An operator can then actuate both switching valves 90, 92 from their second, closed, switching position to their first, open, switching position. Another limiting condition is that shutoff valve 108 is closed.

[0082] Thus, ultrapure water flows from the ultrapure water inlet 20 via the shutoff valve 80, the abutted non-return valve 96, the inlet 68, the inlet connection section 70 of the adapter 66, the first reversing valve 90 controlled to be open, the container inlet 62, and along the solvent flow path 82 through the container 60, dissolving the sodium bicarbonate contained therein. The bicarbonate solution leaves the container 60 via the filter 110 and the container outlet 64 and flows to the dialysate circuit 5 via the second supply flow path 86, the second reversing valve 92 controlled to be open, the outlet connection section 74 of the adapter 66, the abutted non-return valve 98, and the supply path 100.

[0083] the following Figures 2 to 5 An embodiment of a container assembly 58; 158; 258 according to the present disclosure is shown, wherein Figure 3 The implementation method corresponds to Figure 1 An embodiment of a container assembly 58 is shown in FIG.

[0084] Figures 2 to 5 All embodiments of the container assembly 58; 158; 258 shown in FIG are suitable for use with Figure 1 The plug-in container receptacles 68, 72 of the blood treatment machine 1 are coupled and fluidically connected, since the respective adapters 66; 166; 266 of the container assembly are designed topologically, in particular with regard to their connection topology, such that the adapters can be inserted with their inlet connecting sections and outlet connecting sections 70, 74 into the plug-in container receptacles 68, 72 and can be coupled to the inlet 68 and the outlet 72 (see Figure 1 ). Depending on the embodiment, the corresponding fluid connection(s) are then constructed.

[0085] First, it should be noted that the container 60 is Figures 2 to 5 Schematically shown in FIG and essentially only shown to illustrate the different provided flow paths of the alkaline solution.

[0086] Figure 2 The container assembly 158 shown in the embodiment is relatively simple in design. The adapter 166 is designed so that (as described above) the inlet connection section 70 and the outlet connection section 74 can be inserted into their corresponding plug-in container receptacles 68, 72 (see Figure 1 ) and is coupled to its associated inlet 68 or outlet 72. However, only the inlet connection section 70 is provided for fluid connection with the inlet 68. The outlet connection section 74 remains fluid inactive or "blind" and only fulfills the above-mentioned function of occupying or occupying the outlet 72, so that the detection units 76, 78 (see Figure 1) reports to the control unit 54 that the plug-in container receptacles 68, 72 are correctly coupled. Accordingly, the solvent flow path 82 extends from the inlet connection section 70 via the first reversing valve 90 to the container inlet and through the container 60. The first reversing valve is designed as a manually operable 2 / 2 reversing valve with two switching positions. A first supply flow path 84 extends from the container outlet 64, to which a nozzle 112 is connected. The nozzle 112 can be inserted into the container 8, for example, in order to fill the container. The first reversing valve 90 is switched to its first switching position, thereby forming the solvent flow path 82 and the first supply flow path 84. In its second switching position (not shown), the solvent flow path 82 is blocked and ultrapure water no longer flows to the container 60.

[0087] Figure 3 Shown installed in accordance with Figure 1 1 . The switching valves 90, 92 are switched to their first switching position, thereby forming the solvent flow path 82 and the second supply flow path 86. In its second switching position (not shown), the solvent flow path 82 is blocked, and ultrapure water no longer flows to the container 60, and the alkaline solution no longer flows to the outlet connection section 74.

[0088] Figure 4 and Figure 5 A container assembly 258 according to a third embodiment is shown. Here, a bypass flow path 88 branches off from the inlet connection section 70 within the adapter 266, via which the inlet connection section 70 can be connected directly to the outlet connection section 74 of the adapter 266 while bypassing the container 60. In order to be able to switch the solvent flow path 82 via the container 60 and the bypass flow path 88, the reversing valves 190, 192 are designed as manually operable 3 / 2-way valves with three connections and two switching positions, so that in the first switching position of the reversing valves 190, 192 (see Figure 4 ) blocks the bypass flow path and the solvent flow path 82 and the second preparation flow path 86 are controlled to be open, while in the second switching position of the reversing valves 190, 192 (see Figure 5 ) The bypass flow path is controlled to be open and the solvent flow path 82 and the second supply flow path 86 are blocked. By means of the bypass flow path in the adapter 266, the sterilization of the fluid system can preferably be carried out from the solvent / ultrapure water inlet 20 through the plug-in container receptacles 68, 72 and the dialysate circuit 5 by flushing with a sterilizing liquid without having to replace the container 60. The container is simply bypassed by the fluid during sterilization (see Figure 5 ) and after sterilization by simply switching the reversing valves 190, 192 to the first switching position (see Figure 4 ) and “activate” it again.

[0089] Figures 6 to 8 Three embodiments of a container 60 are shown, which differ in where the container outlet is located and how the solvent flow path extends within the container.

[0090] For according to Figures 6 to 8 In common with the various embodiments, the container 60 has a cylindrical or rectangular basic shape with rounded edges and / or corners. A screw cap 114 is arranged on the top, through which a container inlet 62, which is configured as an inlet pipe, passes. Thus, the solvent / ultrapure water enters the container 60 through the relatively short inlet pipe 62. Diametrically with the screw cap 114, the container has a recess 116 on the bottom side, which is slightly larger than the screw cap 114. Thus, multiple such containers 60 can be stacked, wherein the screw cap 114 of the lower container 60 engages in the recess 116 of the container 60 arranged above it, thereby fixing the stacked containers 60 in position. Furthermore, the container 60 has a scale 118 and is made of a transparent plastic, such as PE or PET, so that it is always visible how much dry substance / dissolved dry substance is still contained in the container 60.

[0091] A further effect of the above-mentioned recess 116 is that an annular, relatively narrow area is formed in the container 60 on the periphery of the recess 116, which is suitable for removing the alkaline solution. Figures 6 to 8 In all three embodiments of the container 60 , the removal is effected at the lowest point or lowest area.

[0092] according to Figures 6 to 8 The embodiments of the container 60 differ only in the arrangement of the container outlet 64 .

[0093] according to Figure 6 The container outlet 64 is formed on the screw cap 114, wherein a dip tube 120 is provided, which extends from the lowest point / lowest area to the screw cap 114 and passes through the screw cap. At the lowest point, the confluence of the dip tube 120 is covered by a filter 122 to prevent any dry matter that has not yet dissolved from penetrating the dip tube 120.

[0094] according to Figure 7 The container outlet 64 is formed on the edge of the container 60, wherein a dip tube 124 is provided, which extends from the lowest point / lowest area to the container outlet 64 on the edge. Here, the confluence of the dip tube 122 is also covered by a filter 122 at the lowest point in order to prevent the penetration of undissolved dry matter into the dip tube 120.

[0095] according to Figure 8, the container outlet 64 is configured at the edge at the lowest point / lowest area of ​​the container 60, so that a dip tube can be omitted. In this case, a filter 122 is connected upstream of the confluence of the container outlet 64 into the container to prevent the penetration of still undissolved dry matter into the container outlet 64.

Claims

1. A container assembly (58) for an extracorporeal blood treatment machine (1), which is arranged and designed for intermittent or outpatient blood treatment, wherein: The container assembly is provided and designed as a replacement for an insertable container with a predetermined topology for an extracorporeal blood treatment machine (1) for providing an alkaline solution, in particular a bicarbonate solution, and comprises: a container (60) arranged and configured to receive the alkaline dry substance, to contact the solvent and to provide the alkaline solution, the container comprising a container inlet (62) and a container outlet (64), the container inlet being arranged and configured for fluid connection to the solvent inlet (20) of the blood treatment machine (1), the container outlet being arranged and configured for providing the alkaline solution, in particular to the dialysate circuit (5) of the extracorporeal blood treatment machine (1), an adapter (66) which is arranged and designed for insertion into a plug-in container receptacle (68, 72) of the extracorporeal blood treatment machine (1), the adapter comprising an inlet connecting section (70) which is arranged and designed for coupling and fluid connection to an inlet (68) of the plug-in container receptacle (68, 72) and an outlet connecting section (74) which is arranged and designed at least for coupling, preferably also for fluid connection, to an outlet (72) of the plug-in container receptacle (68, 72), and A solvent flow path (82) is arranged and configured to pass from the inlet connection section (70) of the adapter (66) through the container inlet (62) and to the container outlet (64).

2. The container assembly (158) according to claim 1, characterized in that A supply flow path (84) starting from the container outlet (64) and bypassing the outlet connecting section (74) of the adapter (166) is provided for supplying to the dialysate circuit (5) of the extracorporeal blood treatment machine (1).

3. The container assembly (58; 258) according to claim 1, characterized in that A supply flow path (86) starting from the container outlet (64) and leading to the outlet connecting section (74) of the adapter (66; 266) is provided for supplying the alkaline solution to the dialysate circuit (5) of the extracorporeal blood treatment machine (1).

4. The container assembly (58) according to claim 3, characterized in that A bypass flow path (88) is provided from the inlet connecting section (70) of the adapter (266) to the outlet connecting section (74) of the adapter (266), bypassing the container (60).

5. The container assembly (58; 158; 258) according to claim 3 or 4, characterized in that A first reversing valve (90; 190) having a switching position is provided downstream of the inlet connection section (70) of the adapter (66; 166; 266), wherein the solvent flow path (82) is controlled to be open in the first switching position of the first reversing valve (90; 190) and is blocked in the second switching position of the first reversing valve (90; 190).

6. The container assembly (58; 258) according to any one of claims 3 to 5, characterized in that A second reversing valve (92; 192) having a switching position is arranged upstream of the outlet connecting section (74) of the adapter (66; 266), wherein the supply flow path (86) is controlled to be open in a first switching position of the second reversing valve (92; 192) and is blocked in a second switching position of the second reversing valve (92; 192).

7. The container assembly (58) according to claims 4 to 6, characterized in that The bypass flow path (88) is blocked by a first switching position of the two switching valves (190, 192) and is controlled to be open by a second switching position of the two switching valves (190, 192).

8. The container assembly (58; 158; 258) according to any one of the preceding claims, characterized in that The container inlet (62) and the container outlet (64) are arranged at the highest point or the highest area of ​​the container (60), wherein the immersion pipe (120) extends from the container outlet (64) into the container (60), and the immersion pipe merges into the lowest point or the lowest area of ​​the container (60), or the container inlet (62) is arranged at the highest point or the highest area of ​​the container (60) and the container outlet (64) is arranged on the edge side, wherein the immersion pipe (124) extends from the container outlet (64) into the container (60), and the immersion pipe merges into the lowest point or the lowest area of ​​the container (60), or the container inlet (62) is arranged at the highest point or the highest area of ​​the container (60) and the container outlet (64) is arranged at the lowest point or the lowest area of ​​the container (60).

9. An extracorporeal blood treatment machine (1), in particular a dialysis machine, which is arranged and designed for intermittent or outpatient extracorporeal blood treatment of the blood of a patient (P), comprising at least: - dialyzer (2), a dialysate circuit (5) extending through the dialyzer (2) via a dialysate inlet (2.1) and a dialysate outlet (2.2) of the dialyzer (2), a mixing unit (6) which is designed and adapted to mix at least ultrapure water and an alkaline dry substance, preferably a bicarbonate dry substance, to form an alkaline solution and to supply the alkaline solution to the dialysate circuit (5), - an insertable container receptacle (68, 72), in particular of the mixing unit (6), which is arranged and designed for coupling and fluid connection with an insertable container designed with a predetermined topology for providing the alkaline solution, and which has an inlet (68) which is fluidically connectable, in particular connected, to a solvent inlet (20) of the extracorporeal blood treatment machine (1), and an outlet (72) which is fluidically connectable, in particular connected, to the dialysate circuit (5) for providing the alkaline solution, wherein The inlet (68) and the outlet (72) of the insertable container receptacle (68, 72) are arranged and configured in a predetermined manner relative to one another, in particular according to a predetermined topology of the insertable container. It is characterized in that A container assembly (58) according to any of the above claims is provided, wherein an adapter (66) of the container assembly is preferably inserted into the insertable container receptacle (68, 72) instead of the insertable container, wherein the inlet connecting section (70) of the adapter (66) is coupled to the inlet (68) of the insertable container receptacle (68, 72) and is fluidically connected, the outlet connecting section (74) of the adapter (66) is at least coupled to the outlet (72) of the insertable container receptacle (68, 72), and at least the solvent flow path (82) is provided and can be constructed, in particular constructed to run from the inlet connecting section (70) of the adapter (66) via the container inlet (62) of the container (60), through the container (60) and to the container outlet (64).

10. The extracorporeal blood treatment machine (1) according to claim 9, characterized in that A detection unit (76, 78), in particular a sensor unit, is provided and adapted to detect whether the coupling is constructed and output a signal depending on the result of the detection, wherein a control unit (54) of the blood treatment machine (1) which is signal-connected to the detection unit (76, 78) is provided and adapted to control the fluid connection between the solvent inlet (20) and the inlet (68) of the insertable container receiving portion (68) to be opened when it is detected that both couplings are constructed, preferably by operating a shut-off valve (80) arranged between the solvent inlet (20) and the inlet (68), and to shut off the fluid connection when it is detected that only one coupling is constructed or no coupling is constructed.

11. The extracorporeal blood treatment machine (1) according to claim 9 or 10, characterized in that A supply flow path (84) starting from the container outlet (64) and bypassing the outlet connection section (74) of the adapter (166) to the dialysate circuit (5) is provided and configured to supply an alkaline solution to the dialysate circuit (5).

12. The extracorporeal blood treatment machine (1) according to claim 9 or 10, characterized in that A supply flow path (86) starting from the container outlet (64) and leading to the dialysate circuit (5) via the outlet connection section (74) of the adapter (66; 266) is provided and constructed to supply an alkaline solution to the dialysate circuit (5).

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