Synthesis method of 2-pyridine sulfonyl fluoride
The invention involves oxidizing 2-mercaptopyridine with hydrochloric acid and sodium hypochlorite to generate a sulfonyl chloride intermediate, which is then subjected to a substitution reaction with potassium bifluoride in the presence of a phase transfer catalyst. This solves the problems of low efficiency and high cost in the synthesis of sulfonyl fluoride in the prior art, achieves a high-yield and simplified preparation of 2-pyridinesulfonyl fluoride, and is suitable for industrial production.
Patent Information
- Application Number
- CN202510802957.6
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-06-16
- Publication Date
- 2025-09-26
AI Technical Summary
Existing methods for synthesizing sulfonyl fluoride are inefficient, require high raw material consumption, have poor process stability, are difficult to industrialize, and lack universality and functional group compatibility for complex drug molecules.
2-Pyridinesulfonyl fluoride is prepared through a one-pot process by oxidizing 2-mercaptopyridine with hydrochloric acid and sodium hypochlorite to generate a sulfonyl chloride intermediate, which is then subjected to a substitution reaction with potassium bifluoride in the presence of a phase transfer catalyst. The temperature and solvent conditions are controlled to simplify the post-processing process.
The method improves the yield of 2-pyridinesulfonyl fluoride, reduces the production cost, simplifies the operation process, is suitable for batch production, and has high efficiency and high yield industrial application potential.