Mirror image registration-based bone scaffold fusion design and preparation method

Through the method of mirror registration and structural fusion, a heterogeneous three-periodic minimal surface bone scaffold was designed and printed, which solved the elastic modulus mismatch problem of traditional bone repair materials and achieved personalized bone defect reconstruction with high permeability and high mechanical support.

CN120850648APending Publication Date: 2025-10-28XI AN JIAOTONG UNIV
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Patent Information

Application Number
CN202510842833.0
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-06-23
Publication Date
2025-10-28

AI Technical Summary

Technical Problem

Existing bone repair materials such as titanium alloy and stainless steel lead to stress shielding effect and secondary bone absorption due to the mismatch of elastic modulus. In addition, traditional scaffold structures are difficult to simultaneously meet the needs of mechanical support, cell proliferation and nutrient exchange, and lack personalized design and manufacturing integrated solutions.

Method used

The mirror registration and structure fusion methods were used to obtain the patient's femoral defect area data through CT scanning. The bone scaffold was designed in combination with three-periodic minimal surfaces (TPMS). Diamond and Gyroid structures were used to provide high mechanical support and high permeability in the cortical bone and cancellous bone areas, respectively. SLM technology was used to print Zn-3Mg pre-alloyed powder to achieve heterogeneous gradient distribution.

Benefits of technology

It alleviates the stress shielding effect, improves the permeability and osteogenesis of the backbone scaffold, meets personalized treatment needs, and achieves high-precision bone defect reconstruction.

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Abstract

The invention discloses a bone scaffold fusion design and preparation method based on mirror image registration, and the method comprises the steps: firstly, based on a three-dimensional medical image of a femoral defect region of a patient, combining an opposite-side complete femoral CT image, and achieving the automatic recognition and complementation of the defect region through the mirror image transformation and ICP registration technology; after defect boundary extraction is completed, three-dimensional reconstruction is carried out on the individualized outer contour of the left bone tissue, and an STL format model is exported. According to the femur functional partition characteristics, a Diamond structure is adopted in a cortical bone area to enhance mechanical support, and a Gyandroid structure is selected in a cancellous bone area to achieve porosity gradient filling, so that the permeability is optimized, and cell proliferation is promoted. Continuous transition among the structures is realized through a Sigmoid function, and the stability and the biological adaptability of the whole structure are improved. And finally, the stent model is subjected to selective laser melting, and a Zn-3Mg alloy material is utilized to complete printing manufacturing.
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