Compound and application thereof in preparation of medicine capable of inhibiting Wnt signal channel activity

By developing a compound with a novel structure, Wnt-131, the problem of high IC50 values ​​in existing technologies has been solved, achieving more efficient inhibition of the Wnt signaling pathway. This compound can be used to prepare tablets, capsules, pills, or injections to inhibit liver fibrosis.

CN120943785AActive Publication Date: 2025-11-14GUANGZHOU EIGHTH PEOPLES HOSPITAL GUANGZHOU MEDICAL UNIV
4 Cites 0 Cited by

Patent Information

Application Number
CN202511484729.5
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-10-17
Publication Date
2025-11-14
Estimated Expiration
2045-10-17

AI Technical Summary

Technical Problem

The compounds disclosed in the prior art have high IC50 values ​​in inhibiting the activity of the Wnt signaling pathway, and some compounds do not show relevant activity, making it difficult to effectively inhibit liver fibrosis.

Method used

A novel compound, specifically Wnt-131, has been developed. It has the structure of Formula I and can be used to prepare tablets, capsules, pills or injections by inhibiting the activity of the Wnt signaling pathway, preferably with R1 being a nitro group and R2 being a halogen atom, especially a bromine atom.

Benefits of technology

The IC50 value of compound Wnt-131 is significantly lower than that of compounds in previous patents, demonstrating excellent activity in inhibiting the Wnt signaling pathway and possessing significant application value.

✦ Generated by Eureka AI based on patent content.
Patent Text Reader

Abstract

The invention relates to the technical field of medicinal chemistry, and particularly discloses a compound and application thereof in preparation of a medicine with Wnt signal channel inhibition activity. The compound has a structure as shown in a formula I which is described in the specification. Researches show that the compound disclosed by the invention has the activity of inhibiting a Wnt signal channel; particularly, the IC50 value of the compound Wnt-131 is greatly smaller than that of the compound Wnt-120 and the compound Wnt-133; meanwhile, the compound is also greatly smaller than all compounds in the invention patent CN202410961646. X, and has very excellent activity of inhibiting a Wnt signal channel; therefore, the compound serving as an active ingredient has important application value in preparing the medicine for inhibiting the activity of the Wnt signal channel.
Need to check novelty before this filing date? Find Prior Art