Multidrug-resistant escherichia coli bacteriophage and application thereof

By using Escherichia coli phage vB_EOP_Se004, the treatment challenge of multidrug-resistant Escherichia coli has been solved, achieving efficient and safe bacterial killing and protection of microecological balance, and it has the potential for self-replication and combination therapy.

CN120966767BActive Publication Date: 2026-07-03SHANXI PROVINCE CHINESE MEDICINE RESEARCH INSTITUTE
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHANXI PROVINCE CHINESE MEDICINE RESEARCH INSTITUTE
Filing Date
2025-07-18
Publication Date
2026-07-03

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Abstract

This invention relates to the field of biomedical technology, and particularly to a multidrug-resistant Escherichia coli bacteriophage and its applications. This invention has screened an Escherichia coli bacteriophage, vB_EOP_Se004, which exhibits good killing effects against clinically isolated multidrug-resistant Escherichia coli. It also demonstrates strong tolerance to temperature and pH, maintaining stable survival rates within a pH range of 4-10 and a temperature range of -20°C to 70°C. This bacteriophage can effectively address the resistance of multidrug-resistant Escherichia coli to multiple antibiotics, offering significant advantages in the clinical treatment of infections.
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Citation Information

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