Blood gas analysis method and related device

Abstract

The invention discloses a blood gas analysis method and a related device. The method comprises the following steps: acquiring a target Raman scattering spectrum of mixed gas exhaled by a human body; determining the pressure intensity of each single-component gas contained in the mixed gas exhaled by the human body according to the target Raman scattering spectrum and a plurality of pre-stored Raman intensity-pressure intensity corresponding relations; for each group of single-component gas, determining the concentration of the group of single-component gas based on the total pressure intensity of the mixed gas exhaled by the human body and the pressure intensity of the single-component gas; and determining a blood gas analysis result of the human body based on the concentration of each single-component gas contained in the mixed gas exhaled by the human body. As different single-component gases have different Raman scattering characteristic peaks, the types of the single-component gases included in the mixed gas can be determined after the first scattering spectrum is obtained; and the concentration of each single-component gas can be quantified by combining a pre-stored Raman intensity-pressure corresponding relationship, so that the blood gas analysis result of the human body is determined.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of biomedical detection, in particular to a blood gas analysis method and related device. BACKGROUND

[0002] Blood gas analysis is a core means for clinical diagnosis of respiratory function, acid-base balance and metabolic state, and its results can be directly used to guide disease diagnosis, assess disease severity, develop treatment plans and monitor treatment effects, and can provide key data support for precision medicine.

[0003] The traditional blood gas detection method is to obtain a blood sample by puncturing an artery or a vein, analyze the blood sample, and then obtain the blood gas analysis result; however, this method has the disadvantages of invasiveness, poor real-time performance and complex operation.

[0004] There are currently some non-invasive blood gas detection methods, including but not limited to pulse oximeters and transcutaneous carbon dioxide monitoring, but these non-invasive blood gas detection methods have many shortcomings such as insufficient accuracy (error > 5%) and weak anti-movement interference ability.

[0005] Therefore, how to non-invasively and conveniently obtain a blood gas analysis result with high accuracy has become one of the technical problems to be solved in the technical field of biomedical detection. SUMMARY

[0006] Based on the above problems, the present application provides a blood gas analysis method to non-invasively and conveniently obtain a blood gas analysis result with high accuracy.

[0007] The embodiments of the present application disclose the following technical solutions:

[0008] The first aspect of the present application discloses a blood gas analysis method, comprising:

[0009] obtaining a target Raman scattering spectrum of mixed gas exhaled by a human body;

[0010] determining the pressure of each single-component gas contained in the mixed gas exhaled by the human body based on the target Raman scattering spectrum and a pre-stored plurality of Raman intensity-pressure correspondence relationships; wherein the Raman intensity-pressure correspondence relationship indicates the correspondence between the pressure of a single-component gas in a sample gas and the Raman scattering intensity of the single-component gas; the sample gas is a pure gas containing only target gas molecules;

[0011] For each group of single-component gases, determining the concentration of the group of single-component gases based on the total pressure of the mixed gas exhaled by the human body and the pressure of the single-component gas;

[0012] determine a blood gas analysis result of the human body based on the concentration of each single-component gas contained in the mixed gas exhaled by the human body.

[0013] In an alternative implementation, the determining of the pressure of each single-component gas contained in the mixed gas exhaled by the human body based on the target Raman scattering spectrum and the pre-stored plurality of Raman intensity-pressure correspondences comprises:

[0014] determine a plurality of target single-component gases contained in the mixed gas exhaled by the human body and the Raman scattering intensity of each target single-component gas based on the plurality of peaks of the target Raman scattering spectrum;

[0015] for each target single-component gas, determine the pressure of the target single-component gas based on the Raman scattering intensity of the target single-component gas and the Raman intensity-pressure correspondence corresponding to the target single-component gas.

[0016] In an alternative implementation, the obtaining of the Raman intensity-pressure correspondences comprises:

[0017] obtain a sample gas;

[0018] process the sample gas by a cavity-enhanced Raman spectroscopy technique to obtain the Raman scattering intensity of the sample gas;

[0019] for the sample gas, take the pressure of a single-component gas in the sample gas and the Raman scattering intensity of the sample gas as calibration data of the sample gas;

[0020] obtain the Raman intensity-pressure correspondence corresponding to the single-component gas contained in the sample gas based on the calibration data.

[0021] In an alternative implementation, the method further comprises:

[0022] determine the concentration of each single-component gas contained in the mixed gas inhaled by the human body;

[0023] for each single-component gas contained in the mixed gas inhaled by the human body, determine the net exchange amount of the single-component gas in the human body based on the difference between the concentration of the single-component gas contained in the mixed gas inhaled by the human body and the concentration of the single-component gas contained in the mixed gas exhaled by the human body.

[0024] In an alternative implementation, the determining of the blood gas analysis result of the human body based on the concentration of each single-component gas contained in the mixed gas exhaled by the human body comprises:

[0025] obtain a target mapping table; the target mapping table indicates a corresponding relationship between a component of a mixed gas and a result of blood gas analysis;

[0026] determine a blood gas analysis result based on the target mapping table and a concentration of each single-component gas contained in the mixed gas exhaled by the human body.

[0027] The second aspect of the present application discloses a blood gas analysis device, comprising:

[0028] a target Raman scattering spectrum acquisition module, configured to acquire a target Raman scattering spectrum of a mixed gas exhaled by a human body;

[0029] a mixed gas component determination module, configured to determine a pressure of each single-component gas contained in the mixed gas exhaled by the human body based on the target Raman scattering spectrum and a pre-stored plurality of Raman intensity-pressure corresponding relationships; wherein the Raman intensity-pressure corresponding relationship indicates a corresponding relationship between a pressure of a single-component gas in a sample gas and a Raman scattering intensity of the single-component gas; the sample gas is a pure gas containing only target gas molecules;

[0030] a single-component gas concentration calculation module, configured to, for each group of single-component gases, determine a concentration of the group of single-component gases based on a total pressure of the mixed gas exhaled by the human body and a pressure of the single-component gas;

[0031] a blood gas analysis result determination module, configured to determine a blood gas analysis result of the human body based on a concentration of each single-component gas contained in the mixed gas exhaled by the human body.

[0032] In an optional implementation, the mixed gas component determination module comprises:

[0033] a mixed gas component determination unit, configured to determine a plurality of target single-component gases contained in the mixed gas exhaled by the human body and a Raman scattering intensity of each target single-component gas based on a plurality of peak values of the target Raman scattering spectrum;

[0034] a single-component gas partial pressure determination unit, configured to, for each target single-component gas, determine a pressure of the target single-component gas based on a Raman scattering intensity of the target single-component gas and a Raman intensity-pressure corresponding relationship corresponding to the target single-component gas.

[0035] In an optional implementation, the device further comprises:

[0036] a sample gas acquisition module, configured to acquire a sample gas; the sample gas is a pure gas containing only target gas molecules;

[0037] a Raman scattering intensity determination module configured to determine Raman scattering intensity of the sample gas by processing the sample gas through a cavity-enhanced Raman spectroscopy technique;

[0038] a calibration data determination module configured to, for the sample gas, determine the pressure of a single-component gas in the group of sample gases and the Raman scattering intensity of the group of sample gases as calibration data of the group of sample gases;

[0039] a corresponding relationship determination module configured to, based on the calibration data, determine a Raman intensity-pressure corresponding relationship corresponding to a single-component gas included in the sample gas.

[0040] Compared with the prior art, the present application has the following beneficial effects:

[0041] The present application discloses a blood gas analysis method, comprising: obtaining a target Raman scattering spectrum of mixed gas exhaled by a human body; determining the pressure of each single-component gas contained in the mixed gas exhaled by the human body according to the target Raman scattering spectrum and a pre-stored Raman intensity-pressure corresponding relationship; for each group of single-component gases, determining the concentration of the group of single-component gases based on the total pressure of the mixed gas exhaled by the human body and the pressure of the single-component gas; and determining the blood gas analysis result of the human body based on the concentration of each single-component gas contained in the mixed gas exhaled by the human body. Since different single-component gases have different Raman scattering characteristic peaks, after obtaining the first scattering spectrum, the types of single-component gases included in the mixed gas can be determined; combined with the pre-stored Raman intensity-pressure corresponding relationship, the concentration of each single-component gas can be accurately quantified, and then the blood gas analysis result of the human body can be determined. This detection method based on physical spectrum characteristics can conveniently and non-invasively obtain a blood gas analysis result with high accuracy. BRIEF DESCRIPTION OF DRAWINGS

[0042] In order to more clearly illustrate the technical solutions in the embodiments of the present application or the prior art, the following will briefly introduce the drawings needed to be used in the embodiments or prior art description. Obviously, the drawings in the following description are only some embodiments of the present application, and for those skilled in the art, other drawings can also be obtained without creative labor.

[0043] Figure 1 A flowchart of a blood gas analysis method provided by an embodiment of the present application;

[0044] Figure 2 A flowchart of a Raman intensity-pressure corresponding relationship generation method provided by an embodiment of the present application;

[0045] Figure 3 A structural schematic diagram of a blood gas analysis device provided by an embodiment of the present application. DETAILED DESCRIPTION

[0046] Blood gas analysis is the core means of clinical diagnosis of respiratory function, acid-base balance and metabolic state, and its results can be directly used to guide disease diagnosis, assess disease severity, develop treatment plans, monitor treatment effects, and provide key data support for precision medicine.

[0047] The traditional blood gas detection method is to obtain a blood sample by piercing an artery or vein, analyze the blood sample, and then obtain the blood gas analysis result; but this method has the disadvantages of invasiveness, poor real-time performance, and complex operation.

[0048] There are currently some non-invasive blood gas detection methods, including but not limited to pulse oximeters, transcutaneous carbon dioxide monitoring, etc., but these non-invasive blood gas detection methods have many shortcomings such as insufficient accuracy (error > 5%) and weak anti-motion interference ability.

[0049] Therefore, how to non-invasively and conveniently obtain a blood gas analysis result with high accuracy has become one of the technical problems to be solved in the field of biomedical detection technology.

[0050] To solve the above problems, the present application discloses a blood gas analysis method, comprising: obtaining a target Raman scattering spectrum of mixed gas exhaled by a human body; determining the pressure of each single-component gas contained in the mixed gas exhaled by the human body according to the target Raman scattering spectrum and a pre-stored corresponding relationship between Raman intensity and pressure; for each group of single-component gases, determining the concentration of the single-component gas based on the total pressure of the mixed gas exhaled by the human body and the pressure of the single-component gas; and determining the blood gas analysis result of the human body based on the concentration of each single-component gas contained in the mixed gas exhaled by the human body. Since different single-component gases have different Raman scattering characteristic peaks, the types of single-component gases included in the mixed gas can be determined after the first scattering spectrum is obtained; combined with the pre-stored corresponding relationship between Raman intensity and pressure, the concentration of each single-component gas can be accurately quantified, and then the blood gas analysis result of the human body can be determined. This detection method based on physical spectrum characteristics can non-invasively and conveniently obtain a blood gas analysis result with high accuracy.

[0051] To facilitate understanding of the technical solutions in the present application, the related theories involved in the present application are introduced.

[0052] Cavity-Enhanced Raman Spectroscopy (CERS) is a high-sensitivity spectral analysis technology combining optical resonant cavity and Raman scattering principle. CERS introduces an optical resonant cavity composed of two pieces of high reflectivity mirror (reflectivity is usually > 99.9%), so that the incident laser light undergoes thousands to tens of thousands of round-trip reflections in the cavity, and the effective optical path can reach 10 4 times of the cavity length.

[0053] The principle of cavity-enhanced Raman spectroscopy is shown in formula (1):

[0054] (1)

[0055] In formula (1), represents the Raman scattering signal intensity after cavity enhancement, is the total detection efficiency, is the laser intensity, is the number density of molecules, is the effective interaction length, represents the molecular Raman scattering cross section.

[0056] It can be seen from formula (1) that the interaction time of laser and sample molecules increases with the lengthening of the optical path, and the Raman scattering signal intensity is linearly enhanced, and the signal gain is theoretically proportional to the number of reflections.

[0057] It can be seen from formula (1) that the Raman scattering spectrum and the gas molecules have a good corresponding relationship, and the Raman scattering spectrum of the gas can be regarded as the "fingerprint" of the gas molecules, and the Raman scattering spectrum peak can correspond to the molecular species.

[0058] Raman shift and scattering intensity are the core characteristic parameters of cavity-enhanced Raman scattering. Raman shift refers to the frequency difference between scattered light and incident light, which is determined by the intrinsic vibration energy level and rotation energy level structure of the molecule; and the intensity of the scattered light is related to the concentration of the measured molecules, the incident light power, the Raman scattering cross section of the molecule and other factors. When the experimental conditions are fixed, the scattering intensity is positively correlated with the concentration of the molecules, so the quantitative detection of the substance can be realized by analyzing the intensity.

[0059] In order to enable the personnel in the technical field to better understand the scheme of the present application, the technical solutions in the embodiments of the present application will be described clearly and completely in combination with the drawings in the embodiments of the present application. Obviously, the described embodiments are only a part of the embodiments of the present application, not all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by the person skilled in the art without creative labor are within the scope of protection of the present application.

[0060] Figure 1 ​A flow chart of a blood gas analysis method provided by an embodiment of the present application is shown. The blood gas analysis method disclosed by the present application comprises the following steps. Figure 1

[0061] S101, acquiring a target Raman scattering spectrum of mixed gas exhaled by a human body.

[0062] The mixed gas exhaled by a human body is a complex mixture after gas exchange through the lungs, which is formed on the basis of the composition of inhaled air, combined with human metabolic products and respiratory tract secretions, and mainly includes nitrogen, oxygen, carbon dioxide and other main components, and also includes water vapor, volatile organic compounds and other trace gas components, and also includes ammonia, nitric oxide and other trace gases.

[0063] The target Raman scattering spectrum is an enhanced Raman spectrum obtained by analyzing the mixed gas exhaled by a human body through a cavity-enhanced Raman spectroscopy technique, which contains the vibration or rotation characteristic information of each single component gas molecule in the mixed gas; the horizontal axis of the target Raman scattering spectrum is the Raman shift (unit: wave number), and the vertical axis is the Raman scattering signal intensity (unit: count).

[0064] In an optional implementation, the mixed gas exhaled by a human body can be collected by using a high-airtightness gas bag, and then the mixed gas is input into a Raman spectrum detection system constructed based on a cavity-enhanced Raman spectroscopy technique to obtain a target Raman scattering spectrum of the mixed gas exhaled by a human body.

[0065] S102, determining the pressure of each single component gas contained in the mixed gas exhaled by the human body based on the target Raman scattering spectrum and a pre-stored plurality of Raman intensity-pressure corresponding relationships.

[0066] The Raman intensity-pressure corresponding relationship in the present application indicates the corresponding relationship between the pressure of a single component gas in a sample gas and the Raman scattering intensity of the single component gas.

[0067] The sample gas in the present application refers to a pure gas containing only target gas molecules; wherein the pure gas is a gas substance containing only one gas compound and no impurities and dopants.

[0068] Exemplarily, the Raman intensity-pressure corresponding relationship of oxygen is used to indicate the corresponding relationship between the pressure of oxygen in the sample gas (containing only oxygen as a compound) corresponding to oxygen and the Raman scattering intensity of oxygen.

[0069] Next, the generation method of the Raman intensity-pressure corresponding relationship of oxygen will be described with reference to Figure 2 For example, the generation method of the Raman intensity-pressure corresponding relationship of oxygen will be described with reference to the sample gas corresponding to oxygen. Specifically, the method comprises the following steps.

[0070] S201, acquiring a sample gas.​

[0071] The sample gas in the present application is a pure gas containing only oxygen gas molecules.

[0072] For example, the sample gas corresponding to oxygen refers to a single gas compound containing only oxygen, without any impurities and dopants.

[0073] S202, processing the sample gas by the cavity-enhanced Raman spectroscopy technology to obtain the Raman scattering intensity of the sample gas.

[0074] The sample gas is input into a cavity-enhanced Raman spectroscopy detection system based on the cavity-enhanced Raman spectroscopy technology to obtain the Raman scattering intensity of the sample gas.

[0075] S203, for the sample gas, taking the pressure of the single-component gas in the sample gas and the Raman scattering intensity of the group of sample gas as the calibration data of the group of sample gas.

[0076] S204, based on the calibration data, obtaining the Raman intensity-pressure correspondence relationship corresponding to the single-component gas included in the sample gas.

[0077] After obtaining the Raman intensity-pressure correspondence relationship corresponding to oxygen, once the Raman scattering intensity corresponding to oxygen in the mixed gas is known, the pressure of oxygen in the mixed gas can be determined.

[0078] It can be understood that other gases, such as nitrogen, carbon dioxide, ammonia and nitric oxide, can use the method in S201-S204 to obtain their corresponding Raman intensity-pressure correspondence relationship; in this way, multiple Raman intensity-pressure correspondence relationships can be obtained.

[0079] In an alternative implementation, based on the target Raman scattering spectrum and the pre-stored multiple Raman intensity-pressure correspondence relationships, the specific process of determining the pressure of each single-component gas contained in the mixed gas exhaled by the human body is as follows:

[0080] First, after traversing the target Raman scattering spectrum, the abscissa and ordinate corresponding to the multiple peaks of the target Raman scattering spectrum are determined, i.e., the multiple target single-component gases contained in the mixed gas exhaled by the human body and the Raman scattering intensity of each target single-component gas are determined.

[0081] Exemplarily, through analysis of the target Raman scattering spectrum, it can be identified that the target single-component gases contained in the mixed gas exhaled by the human body are carbon dioxide, oxygen, acetone and nitric oxide. Among them, the Raman scattering intensity of carbon dioxide is I1; the Raman scattering intensity of oxygen is I2; the Raman scattering intensity of acetone is I3; and the Raman scattering intensity of nitric oxide is I4.

[0082] Secondly, from the pre-set plurality of Raman intensity-pressure corresponding relationships (i.e. the plurality of Raman intensity-pressure corresponding relationships pre-generated by the method in the above embodiment), the Raman intensity-pressure corresponding relationship corresponding to each target single-component gas contained in the mixed gas exhaled by the human body is screened out. Figure 2

[0083] For example, the Raman intensity-pressure corresponding relationship corresponding to carbon dioxide, the Raman intensity-pressure corresponding relationship corresponding to oxygen, the Raman intensity-pressure corresponding relationship corresponding to acetone and the Raman intensity-pressure corresponding relationship corresponding to nitric oxide are screened out from the pre-set plurality of Raman intensity-pressure corresponding relationships.

[0084] Thirdly, for each target single-component gas, the partial pressure of the target single-component gas is determined based on the Raman scattering intensity of the target single-component gas and the Raman intensity-pressure corresponding relationship corresponding to the target single-component gas.

[0085] For example, the Raman scattering intensity of carbon dioxide is I1; the Raman scattering intensity of oxygen is I2; the Raman scattering intensity of acetone is I3; and the Raman scattering intensity of nitric oxide is I4.

[0086] After obtaining the Raman intensity-pressure corresponding relationship corresponding to carbon dioxide, the partial pressure P1 of carbon dioxide, the partial pressure P2 of oxygen, the partial pressure P3 of acetone and the partial pressure P4 of nitric oxide can be determined according to the Raman scattering intensity I1 of carbon dioxide, the Raman scattering intensity I2 of oxygen, the Raman scattering intensity I3 of acetone and the Raman scattering intensity I4 of nitric oxide.

[0087] S103, for each group of single-component gases, the concentration of the group of single-component gases is determined based on the total pressure of the mixed gas exhaled by the human body and the pressure of the single-component gas.

[0088] The total pressure of the mixed gas exhaled by the human body can be read in the Raman spectrum detection system.

[0089] After obtaining the pressure of each single-component gas included in the mixed gas exhaled by the human body, the quotient of the pressure (also referred to as the partial pressure) of the single-component gas and the total pressure of the mixed gas exhaled by the human body is taken as the concentration of the group of single-component gases.

[0090] For example, the total pressure of the mixed gas exhaled by the human body is 500 Pa, and the partial pressure of the single-component gas (oxygen) included in the mixed gas exhaled by the human body is 300 Pa, so the concentration of the single-component gas (oxygen) can be obtained as 60%.

[0091] ​S104, determining the blood gas analysis result of the human body based on the concentration of each single-component gas contained in the mixed gas exhaled by the human body.

[0092] After the concentration of each single-component gas contained in the mixed gas exhaled by the human body is obtained, the blood gas analysis result of the human body can be determined in the following manner. Specifically:

[0093] First, a target mapping table is obtained.

[0094] The target mapping table in the present application indicates the corresponding relationship between the composition of the mixed gas and the result of the blood gas analysis; wherein the composition of the mixed gas includes the type of the single-component gas in the mixed gas and the concentration of each single-component gas.

[0095] The target mapping table is obtained in the following manner: the composition (type and concentration of single-component gas) of the mixed gas exhaled by N groups of human bodies is determined by the method in S101 and S103 in the present application; the composition information of the above N groups of mixed gas is matched and compared with the blood gas analysis result of the corresponding individual stored in the medical database, and the correlation between each mixed gas composition feature (such as a specific gas concentration combination) and the blood gas analysis result is determined through statistical analysis; a mapping relationship is constructed based on the above correlation, and finally a target mapping table is generated.

[0096] Then, the concentration of each single-component gas contained in the mixed gas exhaled by the human body is determined from the target mapping table to determine the corresponding blood gas analysis result.

[0097] In an optional implementation, after the concentration of each single-component gas contained in the mixed gas exhaled by the human body is determined by the method in S101-S103, the same method can also be used to determine the concentration of each single-component gas contained in the mixed gas inhaled by the human body; for each single-component gas contained in the mixed gas inhaled by the human body, based on the difference between the concentration of the single-component gas contained in the mixed gas inhaled by the human body and the concentration of the single-component gas contained in the mixed gas exhaled by the human body, the net exchange amount of the single-component gas in the human body is determined.

[0098] In summary, the application discloses a blood gas analysis method, specifically comprising: obtaining a target Raman scattering spectrum of mixed gas exhaled by a human body; determining the pressure of each single-component gas contained in the mixed gas exhaled by the human body according to the target Raman scattering spectrum and a pre-stored plurality of Raman intensity-pressure corresponding relationships; for each group of single-component gases, determining the concentration of the group of single-component gases based on the total pressure of the mixed gas exhaled by the human body and the pressure of the single-component gas; and determining the blood gas analysis result of the human body based on the concentration of each single-component gas contained in the mixed gas exhaled by the human body. Since different single-component gases have different Raman scattering characteristic peaks, after the first scattering spectrum is obtained, the types of single-component gases included in the mixed gas can be determined; in combination with the pre-stored Raman intensity-pressure corresponding relationship, the concentration of each single-component gas can be accurately quantified, and then the blood gas analysis result of the human body is determined. This detection method based on physical spectrum characteristics can non-invasively and conveniently obtain a blood gas analysis result with high accuracy.

[0099] Based on the same inventive concept, the application also discloses a blood gas analysis device. Figure 3 A structural schematic diagram of a blood gas analysis device provided by an embodiment of the application is shown in FIG. 1. In combination with FIG. 1, Figure 3 The blood gas analysis device 300 disclosed by the application comprises:

[0100] A target Raman scattering spectrum acquisition module 301 is configured to obtain a target Raman scattering spectrum of mixed gas exhaled by a human body.

[0101] A mixed gas component determination module 302 is configured to determine the pressure of each single-component gas contained in the mixed gas exhaled by the human body based on the target Raman scattering spectrum and a pre-stored plurality of Raman intensity-pressure corresponding relationships. The Raman intensity-pressure corresponding relationship indicates the corresponding relationship between the pressure of a single-component gas in a sample gas and the Raman scattering intensity of the single-component gas. The sample gas is a pure gas containing only target gas molecules.

[0102] A single-component gas concentration calculation module 303 is configured to, for each group of single-component gases, determine the concentration of the group of single-component gases based on the total pressure of the mixed gas exhaled by the human body and the pressure of the single-component gas.

[0103] A blood gas analysis result determination module 304 is configured to determine the blood gas analysis result of the human body based on the concentration of each single-component gas contained in the mixed gas exhaled by the human body.

[0104] In an optional implementation, the mixed gas component determination module 302 comprises:

[0105] The mixed gas component determination unit is configured to determine, based on the plurality of peaks of the target Raman scattering spectrum, a plurality of target single-component gases contained in the mixed gas exhaled by the human body, and a Raman scattering intensity of each of the target single-component gases.

[0106] The single-component gas partial pressure determination unit is configured to, for each of the target single-component gases, determine a pressure of the target single-component gas based on the Raman scattering intensity of the target single-component gas and a corresponding relationship between the Raman scattering intensity and the pressure of the target single-component gas.

[0107] In an alternative implementation, the blood gas analysis device 300 further comprises:

[0108] The sample gas acquisition module is configured to acquire a sample gas.

[0109] The Raman scattering intensity determination module is configured to process the sample gas by the cavity-enhanced Raman spectroscopy to obtain a Raman scattering intensity of the sample gas.

[0110] The calibration data determination module is configured to, for the sample gas, determine, as calibration data of the sample gas, a pressure of a single-component gas in the sample gas and the Raman scattering intensity of the sample gas.

[0111] The corresponding relationship determination module is configured to obtain, based on the calibration data, a corresponding relationship between the Raman scattering intensity and the pressure of the single-component gas included in the sample gas.

[0112] It should be noted that each of the embodiments in the present specification is described in a progressive manner, and the same or similar parts of each embodiment can be referred to each other. In particular, the device embodiment is described relatively simply because it is basically similar to the method embodiment, and the relevant parts can be referred to the part of the description of the method embodiment. The device embodiment described above is only illustrative, and the units described as separate components can be or can not be physically separated, and the components indicated as units can be or can not be physical units, that is, they can be located in one place or distributed on multiple network units. Part or all of the modules can be selected to achieve the purpose of the embodiment scheme according to actual needs. Those skilled in the art can understand and implement it without creative labor.

[0113] The above describes only one specific implementation of the present application, but the protection scope of the present application is not limited to this. Any skilled person in the art can easily think of changes or replacements within the technical range disclosed in the present application, which should be covered within the protection scope of the present application. Therefore, the protection scope of the present application should be subject to the protection scope of the claims.

Claims

1. A blood gas analysis method, characterized in that, The method includes: Obtain the target Raman scattering spectrum of the mixed gas exhaled by the human body; Based on the target Raman scattering spectrum and multiple pre-stored correspondences between Raman intensity and pressure, the pressure of each single-component gas contained in the mixed gas exhaled by the human body is determined; wherein, the correspondence between Raman intensity and pressure indicates the correspondence between the pressure of a single-component gas in the sample gas and the Raman scattering intensity of that single-component gas; the sample gas is a pure gas containing only target gas molecules. For each group of single-component gases, the concentration of that single-component gas is determined based on the total pressure of the mixed gas exhaled by the human body and the pressure of that single-component gas. The blood gas analysis results of the human body are determined based on the concentration of each individual gas component contained in the mixed gas exhaled by the human body.

2. The method according to claim 1, characterized in that, The determination of the pressure of each individual gas component in the exhaled gas mixture based on the target Raman scattering spectrum and multiple pre-stored Raman intensity-pressure correspondences includes: Based on multiple peaks in the target Raman scattering spectrum, the various target single-component gases contained in the mixed gas exhaled by the human body are determined, as well as the Raman scattering intensity of each target single-component gas; For each of the target single-component gases, the pressure of the target single-component gas is determined based on the Raman scattering intensity of the target single-component gas and the corresponding relationship between the Raman intensity and pressure of the target single-component gas.

3. The method according to claim 1, characterized in that, The steps for obtaining the correspondence between Raman intensity and pressure include: Obtain the sample gas; The sample gas was processed using cavity-enhanced Raman spectroscopy to obtain the Raman scattering intensity of the sample gas. For the sample gas, the pressure of the single component gas in the sample gas and the Raman scattering intensity of the sample gas are used as the calibration data of the sample gas. Based on the calibration data, the Raman intensity-pressure correspondence for the single-component gases included in the sample gas is obtained.

4. The method according to claim 1, characterized in that, The method further includes: Determine the concentration of each individual gas component in the gas mixture inhaled by the human body; For each individual gas contained in the gas mixture inhaled by the human body, the net exchange rate of that individual gas within the human body is determined based on the difference between the concentration of that individual gas in the gas mixture inhaled by the human body and the concentration of that individual gas in the gas mixture exhaled by the human body.

5. The method according to claim 1, characterized in that, The determination of the blood gas analysis results of the human body based on the concentration of each individual gas component contained in the exhaled gas mixture includes: Obtain a target mapping table; the target mapping table indicates the correspondence between the components of the mixed gas and the results of blood gas analysis; The blood gas analysis results are determined based on the target mapping table and the concentration of each single-component gas contained in the mixed gas exhaled by the human body.

6. A blood gas analysis device, characterized in that, The device includes: The target Raman scattering spectrum acquisition module is used to acquire the target Raman scattering spectrum of the mixed gas exhaled by the human body; A mixed gas component determination module is used to determine the pressure of each individual gas component contained in the mixed gas exhaled by the human body based on the target Raman scattering spectrum and multiple pre-stored correspondences between Raman intensity and pressure; wherein, the correspondence between Raman intensity and pressure indicates the correspondence between the pressure of an individual gas component in the sample gas and the Raman scattering intensity of that individual gas component; the sample gas is a pure gas containing only target gas molecules; The single-component gas concentration calculation module is used to determine the concentration of each single-component gas based on the total pressure of the mixed gas exhaled by the human body and the pressure of the single-component gas. The blood gas analysis result determination module is used to determine the blood gas analysis result of the human body based on the concentration of each single component gas contained in the mixed gas exhaled by the human body.

7. The apparatus according to claim 6, characterized in that, The mixed gas component determination module includes: A mixed gas composition determination unit is used to determine, based on multiple peaks of the target Raman scattering spectrum, the various target single-component gases contained in the mixed gas exhaled by the human body, and the Raman scattering intensity of each target single-component gas; The single-component gas partial pressure determination unit is used to determine the pressure of each target single-component gas based on the Raman scattering intensity of the target single-component gas and the correspondence between the Raman intensity and the pressure of the target single-component gas.

8. The apparatus according to claim 6, characterized in that, The device further includes: Sample gas acquisition module, used to acquire sample gas; The Raman scattering intensity determination module is used to process the sample gas using cavity-enhanced Raman spectroscopy to obtain the Raman scattering intensity of the sample gas. The calibration data determination module is used to determine the calibration data of the sample gas by taking the pressure of the single component gas in the sample gas and the Raman scattering intensity of the sample gas as the calibration data of the sample gas. The correspondence determination module is used to obtain the Raman intensity-pressure correspondence between the single-component gases included in the sample gas based on the calibration data.

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