Traditional Chinese medicine formula for treating children adenoid hypertrophy, preparation method and powder

Abstract

The invention relates to a traditional Chinese medicine prescription for treating children adenoid hypertrophy. The formula comprises the following raw materials: peach kernel, safflower, radix scrophulariae, radix paeoniae rubra, bupleurum chinense, platycodon grandiflorum, radix rehmanniae recen, honey-fried licorice root, fructus aurantii, angelica sinensis, magnolia flower, ligusticum wallichii, cocklebur fruit, radix angelicae, astragalus membranaceus and radix ranunculi ternati. According to the present invention, the key pathogenesis of adenoid hypertrophy such as blood stasis stagnation and unsmooth central nervous system is grasped, the method is adopted to regulate the central nervous system, disperse blood stasis and subdue swelling, the addition and the subtraction are performed according to the four clinical syndromes, and the traditional Chinese medicine has characteristics of significant treatment effect, small side effect, safety and reliability in the long-term clinical research and practice, provides the guiding significance for the traditional Chinese medicine diagnosis and treatment of children AH, and has the broad application prospect. The traditional Chinese medicine composition is an effective medicine for treating child adenoid hypertrophy, especially qi and blood stasis type child adenoid hypertrophy.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine formulation technology, and more specifically, to a traditional Chinese medicine formulation, preparation method, and powder for treating adenoid hypertrophy in children. Background Technology

[0002] Adenoid hypertrophy is a common pediatric disease. Studies show that the clinical prevalence of AH in children and adolescents is 34.46%. Childhood adenoid hypertrophy is often a physiological condition. The adenoids, located in the nasopharynx, are lymphatic tissue that physiologically enlarge during childhood, typically peaking at 6-7 years of age, and then gradually shrinking. Common symptoms include nasal congestion, snoring, and mouth breathing, often stemming from pharyngeal infections and recurrent inflammation, and are more common in cold, damp, and climate-fluid regions. Adenoid hypertrophy can cause a series of sequelae, including maxillofacial abnormalities (adenoid facies), growth and developmental delays, secretory otitis media, sinusitis, and obstructive sleep apnea (OSA), severely impacting children's quality of life, intellectual development, and physical health.

[0003] In Western medicine, treatment is divided into conservative treatment and surgical resection. Conservative treatment mostly involves controlling allergies and improving ventilation through nasal corticosteroids, leukotriene inhibitors, and antihistamines. However, children have poor tolerance to these medications, and Western medicine treatments often have significant side effects. Children's cooperation is also low, placing a heavy physical and psychological burden on both the child and their parents in the long run. Furthermore, the long-term efficacy is uncertain. Surgical resection carries risks related to surgery and anesthesia, as well as the possibility of disease recurrence. Many parents and children have concerns and fears about this. Surgical treatment may lead to sequelae such as Eustachian tube damage and nasopharyngeal stenosis. Additionally, the adenoids are important immune organs in children, especially those aged 3-5, playing a crucial role in the local immune function of the pharynx and the entire upper respiratory tract. Therefore, there is an urgent need for a more effective, comprehensive, safe, and reliable traditional Chinese medicine approach to treat the symptoms. Summary of the Invention

[0004] The technical problem to be solved by the present invention is to provide a traditional Chinese medicine formula for treating adenoid hypertrophy in children, in view of the above-mentioned defects of the prior art, as well as a method for preparing traditional Chinese medicine for treating adenoid hypertrophy in children and a traditional Chinese medicine powder for treating adenoid hypertrophy in children.

[0005] The technical solution adopted by this invention to solve its technical problem is: A traditional Chinese medicine formula for treating adenoid hypertrophy in children was constructed, comprising the following components: peach kernel 3-5g, safflower 3-5g, scrophularia ningpoensis 1-3g, red peony root 1-3g, bupleurum root 1-3g, platycodon root 1-3g, prepared licorice root 1-3g, rehmannia root 5-8g, immature bitter orange peel 1-3g, angelica root 1-3g, magnolia flower 3-5g, angelica dahurica root 3-5g, chuanxiong rhizome 1-3g, cocklebur fruit 1-3g, cat's claw herb 3-5g, and astragalus root 3-5g.

[0006] The traditional Chinese medicine formula for treating adenoid hypertrophy in children as described in this invention comprises the following components: 5g peach kernel, 5g safflower, 2g scrophularia, 3g red peony root, 2g bupleurum root, 3g platycodon root, 3g prepared licorice root, 8g rehmannia root, 3g immature bitter orange peel, 3g angelica root, 5g magnolia flower, 5g angelica dahurica root, 3g chuanxiong rhizome, 3g cocklebur fruit, 5g cat's claw herb, and 5g astragalus root.

[0007] The traditional Chinese medicine formula for treating adenoid hypertrophy in children as described in this invention comprises the following components: 3g peach kernel, 5g safflower, 2g scrophularia, 2g red peony root, 2g bupleurum root, 3g platycodon root, 2g prepared licorice root, 8g rehmannia root, 3g immature bitter orange peel, 3g angelica root, 5g magnolia flower, 5g angelica dahurica root, 3g chuanxiong rhizome, 3g cocklebur fruit, 3g cat's claw herb, and 5g astragalus root.

[0008] The traditional Chinese medicine formula for treating adenoid hypertrophy in children as described in this invention comprises the following components: 3g peach kernel, 3g safflower, 1g scrophularia, 2g red peony root, 2g bupleurum root, 3g platycodon root, 2g prepared licorice root, 6g rehmannia root, 2g immature bitter orange peel, 2g angelica root, 4g magnolia flower, 4g angelica dahurica root, 2g chuanxiong rhizome, 2g cocklebur fruit, 5g cat's claw herb, and 3g astragalus root.

[0009] The traditional Chinese medicine formula for treating adenoid hypertrophy in children as described in this invention comprises the following components: 5g peach kernel, 3g safflower, 1g scrophularia, 2g red peony root, 3g bupleurum root, 3g platycodon root, 3g prepared licorice root, 6g rehmannia root, 2g immature bitter orange peel, 2g angelica root, 4g magnolia flower, 4g angelica dahurica root, 3g chuanxiong rhizome, 2g cocklebur fruit, 3g cat's claw herb, and 5g astragalus root.

[0010] The traditional Chinese medicine formula for treating adenoid hypertrophy in children as described in this invention comprises the following components: 5g peach kernel, 4g safflower, 2g scrophularia, 1g red peony root, 3g bupleurum root, 3g platycodon root, 3g prepared licorice root, 6g rehmannia root, 2g immature bitter orange peel, 2g angelica root, 3g magnolia flower, 3g angelica dahurica root, 1g chuanxiong rhizome, 1g cocklebur fruit, 3g cat's claw herb, and 5g astragalus root.

[0011] The traditional Chinese medicine formula for treating adenoid hypertrophy in children as described in this invention comprises the following components: 4g of peach kernel, 4g of safflower, 2g of scrophularia, 3g of red peony root, 1g of bupleurum root, 2g of platycodon root, 1g of prepared licorice root, 6g of rehmannia root, 3g of immature bitter orange peel, 1g of angelica root, 3g of magnolia flower, 5g of angelica dahurica root, 2g of chuanxiong rhizome, 2g of xanthium fruit, 5g of cat's claw herb, and 3g of astragalus root.

[0012] The traditional Chinese medicine formula for treating adenoid hypertrophy in children as described in this invention comprises the following components: 4g of peach kernel, 5g of safflower, 3g of scrophularia, 1g of red peony root, 1g of bupleurum root, 1g of platycodon root, 3g of prepared licorice root, 6g of rehmannia root, 1g of immature bitter orange peel, 3g of angelica root, 5g of magnolia flower, 3g of angelica dahurica, 3g of chuanxiong rhizome, 1g of cocklebur fruit, 4g of cat's claw herb, and 4g of astragalus root.

[0013] A method for preparing a traditional Chinese medicine for treating adenoid hypertrophy in children, wherein the method includes the following steps: Material selection and proportioning: Select medicinal materials according to the above-mentioned traditional Chinese medicine formula for treating adenoid hypertrophy in children, ensuring that they are free from insects, mold, and mildew, and weigh and verify the proportions according to the formula; Drying and coarse grinding: Place the medicinal materials in a cool and ventilated place to dry thoroughly; first use a pulverizer to perform preliminary crushing to facilitate subsequent fine grinding; Fine grinding: Use an ultra-fine pulverizer to grind the medicinal materials into fine powder, requiring the powder to be uniform and free of particles; Sieving and mixing: Filter the powder through an 80-100 mesh sieve, and re-grind any coarse particles that are not sieved; when mixing, stir in batches using an equal-increment method to ensure uniform distribution; Sterilization treatment: Spread the powder evenly in a sterilization container and irradiate with ultraviolet light for 30 minutes; Packaging and storage: Pack into sterilized light-proof bags, label with name, date and usage; store in a cool, dry place, and check regularly for moisture and clumping.

[0014] A traditional Chinese medicine powder for treating adenoid hypertrophy in children, wherein the powder is prepared by the traditional Chinese medicine preparation method for treating adenoid hypertrophy in children as described above.

[0015] The beneficial effects of this invention are as follows: 1. This formula is based on the theory of "opening, closing, and pivoting of the three Yin and three Yang" and uses the method of "regulating the pivot, resolving stasis and reducing swelling" to provide an innovative new approach to the treatment of adenoid hypertrophy in children with traditional Chinese medicine. It provides a reference for pediatric clinicians. The prescription and medication of this formula are scientific and reasonable. Through the understanding and further application of "opening, closing, and pivoting of the three Yin and three Yang" in the "Huangdi Neijing", it reflects the flexibility and practicality of traditional medicine in modern pediatrics. It can further deepen the understanding of the treatment of adenoid hypertrophy in children with traditional Chinese medicine from the perspective of theory and actual clinical efficacy.

[0016] 2. This formula focuses on "holistic conditioning and syndrome differentiation and treatment," aiming to fundamentally improve the child's constitution, alleviate symptoms, and reduce recurrence. It reduces the blockage of the posterior nasal cavity by the adenoids, relieving primary symptoms such as nasal congestion, mouth breathing, and snoring during sleep. It also reduces the involvement of adjacent organs, lessens the impact of adenoid inflammation on the Eustachian tube and sinuses, and reduces the frequency of otitis media (ear pain, hearing loss) and sinusitis (purulent nasal discharge, headache), providing comprehensive protection for the child's quality of life after treatment.

[0017] 3. Compared to long-term use of nasal corticosteroids (such as mometasone furoate) or antibiotics, this formula has the advantage of being "primarily natural medicine with fewer systemic side effects": For children requiring long-term symptom control, this formula can reduce the frequency of corticosteroid use (e.g., changing from "daily nasal spray" to "every other day nasal spray"), reducing local side effects such as nasal dryness and nosebleeds, making it especially suitable for young children with poor tolerance to corticosteroids. It can also reduce antibiotic overuse, lower the probability of recurrent adenoid infections by regulating immunity, reduce repeated antibiotic use due to the vicious cycle of "inflammation-hyperplasia," and reduce the risk of drug resistance. Attached Figure Description

[0018] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the present invention will be further described below in conjunction with the accompanying drawings and embodiments. The drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort: Figure 1 This is a flowchart of a traditional Chinese medicine preparation method for treating adenoid hypertrophy in children, according to a preferred embodiment of the present invention. Detailed Implementation

[0019] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, a clear and complete description will be provided below in conjunction with the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, of the embodiments of the present invention. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without creative effort are within the protection scope of the present invention.

[0020] The preferred embodiment of the present invention provides a traditional Chinese medicine formula for treating adenoid hypertrophy in children, comprising the following components: 3-5g of peach kernel, 3-5g of safflower, 1-3g of scrophularia, 1-3g of red peony root, 1-3g of bupleurum root, 1-3g of platycodon root, 1-3g of prepared licorice root, 5-8g of rehmannia root, 1-3g of immature bitter orange peel, 1-3g of angelica root, 3-5g of magnolia flower, 3-5g of angelica dahurica, 1-3g of chuanxiong rhizome, 1-3g of xanthium fruit, 3-5g of cat's claw herb, and 3-5g of astragalus root; The key technical point of this invention lies in the drug combination and treatment approach of this formula. This formula is based on Si Ni San and Tao Hong Si Wu Tang, and is modified and adjusted according to Dr. Lin Guobin's many years of experience in medication. It has the innovation of compound compatibility and the precision of indications. The core value of this formula lies in achieving "synergistic effect" or "reduction of toxicity" through compatibility. At the same time, this formula is based on the theory of "opening, closing and pivoting of the three yin and three yang", rooted in the classics of traditional Chinese medicine and branched by clinical experience, and has constructed another diagnostic and treatment system for treating adenoid hypertrophy in children. It is pioneering and developmental.

[0021] One possible implementation example: The components include 5g of peach kernel, 5g of safflower, 2g of scrophularia, 3g of red peony root, 2g of bupleurum root, 3g of platycodon root, 3g of prepared licorice root, 8g of rehmannia root, 3g of immature bitter orange peel, 3g of angelica root, 5g of magnolia flower, 5g of angelica dahurica, 3g of chuanxiong rhizome, 3g of cocklebur fruit, 5g of cat's claw herb, and 5g of astragalus root.

[0022] One possible implementation example: The components include 3g of peach kernel, 5g of safflower, 2g of scrophularia, 2g of red peony root, 2g of bupleurum root, 3g of platycodon root, 2g of prepared licorice root, 8g of rehmannia root, 3g of immature bitter orange peel, 3g of angelica root, 5g of magnolia flower, 5g of angelica dahurica, 3g of chuanxiong rhizome, 3g of cocklebur fruit, 3g of cat's claw herb, and 5g of astragalus root.

[0023] One optional embodiment includes: 3g of peach kernel, 3g of safflower, 1g of scrophularia, 2g of red peony root, 2g of bupleurum root, 3g of platycodon root, 2g of prepared licorice root, 6g of rehmannia root, 2g of immature bitter orange peel, 2g of angelica root, 4g of magnolia flower, 4g of angelica root, 2g of chuanxiong rhizome, 2g of cocklebur fruit, 5g of cat's claw herb, and 3g of astragalus root.

[0024] One possible implementation example: The components include 5g of peach kernel, 3g of safflower, 1g of scrophularia, 2g of red peony root, 3g of bupleurum root, 3g of platycodon root, 3g of prepared licorice root, 6g of rehmannia root, 2g of immature bitter orange peel, 2g of angelica root, 4g of magnolia flower, 4g of angelica root, 3g of chuanxiong rhizome, 2g of cocklebur fruit, 3g of cat's claw herb, and 5g of astragalus root.

[0025] One possible implementation example: The components include 5g of peach kernel, 4g of safflower, 2g of scrophularia, 1g of red peony root, 3g of bupleurum root, 3g of platycodon root, 3g of prepared licorice root, 6g of rehmannia root, 2g of immature bitter orange peel, 2g of angelica root, 3g of magnolia flower, 3g of angelica dahurica, 1g of chuanxiong rhizome, 1g of cocklebur fruit, 3g of cat's claw herb, and 5g of astragalus root.

[0026] One possible implementation example: The components include 4g of peach kernel, 4g of safflower, 2g of scrophularia, 3g of red peony root, 1g of bupleurum root, 2g of platycodon root, 1g of prepared licorice root, 6g of rehmannia root, 3g of immature bitter orange peel, 1g of angelica root, 3g of magnolia flower, 5g of angelica dahurica, 2g of chuanxiong rhizome, 2g of cocklebur fruit, 5g of cat's claw herb, and 3g of astragalus root.

[0027] One optional embodiment includes: 4g of peach kernel, 5g of safflower, 3g of scrophularia, 1g of red peony root, 1g of bupleurum root, 1g of platycodon root, 3g of prepared licorice root, 6g of rehmannia root, 1g of immature bitter orange peel, 3g of angelica root, 5g of magnolia flower, 3g of angelica dahurica, 3g of chuanxiong rhizome, 1g of cocklebur fruit, 4g of cat's claw herb, and 4g of astragalus root; It should be noted that, in addition to the examples of combined components listed above, the components can be fine-tuned as needed to obtain other implementation examples, and the components obtained in this way also fall within the scope of protection of this application. The pharmacological explanation of this prescription is as follows: Regarding the existing technologies for treating adenoid hypertrophy using traditional Chinese medicine, the following problems mainly exist: 1. While effective in eliminating phlegm and blood stasis, it lacks comprehensive protection: Current prescriptions for treating adenoid hypertrophy in children mainly focus on "resolving phlegm and blood stasis and clearing nasal passages," emphasizing the elimination of phlegm and blood stasis, but lacking synergistic regulation of the child's qi and blood production. This prescription, however, is based on the theory of "the opening, closing, and pivoting of the three yin and three yang," taking a holistic approach to the patient's entire system, thus achieving a comprehensive regulatory effect on the patient's qi and blood production.

[0028] 2. Lack of unified standards for syndrome differentiation and prescription selection: The core of TCM treatment is "treatment based on syndrome differentiation," but there is currently no consensus on the syndrome differentiation of adenoid hypertrophy in children. Some treatment plans use medication blindly without clearly identifying the syndrome of adenoid hypertrophy in patients. This prescription is mainly for treating patients with adenoid hypertrophy of the Qi stagnation and blood stasis type. The prescription and medication are clearly defined. It is composed of Si Ni San (Four-Reversal Powder) with Zhi Ke (Fructus Aurantii Immaturus) instead of Zhi Shi (Fructus Aurantii Immaturus), combined with Tao Hong Si Wu Tang (Four-Substance Decoction with Radix Scrophulariae), Jie Geng (Radix Platycodi), Xin Yi (Flos Magnoliae), Cang Er Zi (Fructus Xanthii), and Bai Zhi (Radix Angelicae Dahuricae). It is a one-syndrome-one-prescription, with a unified standard.

[0029] 3. Insufficient safety research and potential risks not fully understood: Some existing treatment regimens for adenoid hypertrophy do not have clearly defined toxic components of drugs, or the dosage range of related drugs is ambiguous, posing risks to medication and concerns about the safety of long-term use; this prescription follows medication guidelines, with reasonable drug combinations, combining therapeutic effects with supplementation, resulting in good efficacy and few side effects.

[0030] In response to the above issues, our side proposed the following: 1. Treatment Approach: Adenoid hypertrophy is essentially a disorder of the Qi mechanism of the Three Yin and Three Yang in the nasopharyngeal axis. Shao Yang, the "Yang pivot," governs the ascending and descending of Qi and the release of ministerial fire, regulating the water passages of the Triple Burner. Children with a "Shao Yang constitution" often have an excess of ministerial fire. If this pivot is obstructed, the ministerial fire stagnates and transforms into heat, which condenses into phlegm, attacking the throat and obstructing the nasopharynx, stimulating adenoid hyperplasia. Shao Yin, the "Yin pivot," governs the heart and kidneys, governing the balance of water and fire and the warming of primordial Qi. Children's kidney Qi is not yet sufficient; if the Shao Yin pivot is impaired, Yang Qi fails to ascend, and Yin cold stagnates, easily leading to phlegm and blood stasis in the nasopharynx. This formula focuses on "regulating the pivot, resolving blood stasis and reducing swelling," aiming to improve adenoid hypertrophy and related symptoms in children by regulating the Shao Yang and Shao Yin pivots, promoting the production of Qi and blood.

[0031] 2. Issues regarding formula selection and herb application: "On the Separation and Integration of Yin and Yang" states that "Taiyang and Taiyin are related to the opening, Yangming and Jueyin are related to the closing, and Shaoyang and Shaoyin are related to the pivot." Professor Gu Zhishan believes that there are also three states of opening, closing, and pivot in the operation of the body's qi mechanism. Combining the Hetu Luoshu and the Yin-Yang Taiji diagram, he drew the Gu's Three Yin and Three Yang Opening-Closing-Pivot Diagram. "Hang Sang Xiaozhong San" is developed under the guidance of Professor Gu Zhishan's academic thought. Based on the theory of "Three Yin and Three Yang Opening-Closing-Pivot," it focuses on the two pivots of "Shaoyang and Shaoyin," and is formulated with the principle of "regulating the pivot mechanism, promoting blood circulation to remove stasis, and reducing swelling." The whole formula is composed of Sini Powder with Fructus Aurantii substituted for Fructus Aurantii Immaturus, combined with Taohong Siwu Decoction, plus Scrophulariae Radix, Platycodonis Radix, Magnoliae Flos, Xanthii Fructus, and Angelicae Dahuricae Radix. Sini Powder regulates qi and blood; Taohong Siwu Decoction nourishes blood and promotes blood circulation, activates qi and removes stasis. Ligustici Chuanxiong Rhizoma has a pungent, warm, and fragrant nature, and it may damage body fluids, so Scrophulariae Radix is added to assist Rehmanniae Radix in nourishing yin and also detoxifying and dissipating nodules; Platycodonis Radix disperses the lung qi and reduces swelling; Bupleuri Radix and Fructus Aurantii regulate qi movement and direct all the herbs for promoting blood circulation and removing stasis to the affected area. Magnoliae Flos, Xanthii Fructus, and Angelicae Dahuricae Radix dispel wind, relieve the exterior syndrome, and promote yang and open the nasal passages. The combination of these herbs can relieve qi stagnation, remove blood stasis, reduce swelling and fullness, and open the nasal passages. This formula can improve problems such as nasal congestion, snoring, and mouth breathing in children due to adenoid hypertrophy, and at the same time, it can improve and prevent the adenoid facies in children, safeguarding the health and future development of children. <> <>

[0032] Efficacy and Compatibility Features: <> 1. This formula focuses on Shaoyin and Shaoyang, mainly playing the role of regulating the pivot mechanisms of Shaoyin and Shaoyang and restoring the normal ascending, descending, exiting, and entering of qi. In the formula, Bupleuri Radix, Fructus Aurantii, Paeoniae Radix Rubra, and Glycyrrhizae Radix Preparata are modified from Sini Powder, which mainly treats the qi aspect of Shaoyang. Among them, Bupleuri Radix is bitter, flat, and slightly pungent, which can disperse the clear qi of Shaoyang; Fructus Aurantii is bitter and cold, promoting downward movement, and when combined with Bupleuri Radix, the ascending and descending are coordinated, and they can disperse the stagnant qi of Shaoyang; Jueyin and Shaoyang are exterior-interior related, and Paeoniae Radix Rubra can dredge Jueyin to benefit Shaoyang; Glycyrrhizae Radix Preparata harmonizes the middle qi, and when the middle qi is sufficient, qi and blood are abundant, which can support the qi of Shaoyang.桃仁、红花、生地、川芎、当归、赤芍又为桃红四物汤,主治少阴血分,以红花、川芎、当归之辛窜活血,以桃仁、生地之柔润养血,则血分充盈而流行不息;病位在颃颡,位属上焦,故见桔梗开宣肺气、引药上行;痰瘀互结,故加玄参以解毒散结,加猫爪草软坚散结。腺样体肥大总体表现以鼻窍不通为主,故加辛夷、苍耳子、白芷以轻清通宣鼻窍;肺开窍于鼻,故加黄芪以补肺气以助呼吸。方中气血同调、标本兼治,可使气郁舒、瘀血去、肿实消、鼻窍通。(There seems to be some repetition in the original text here. The part about Taohong Siwu Decoction is repeated. Assuming it's a mistake, the translation is based on the overall context. If you can correct the original text, it will be more accurate for translation.) <> <>

[0033] The medicinal properties of the active ingredients used in this invention are as follows: <> Peach kernel: Bitter and sweet in taste, neutral in nature, and enters the heart, liver, and large intestine meridians. It has the functions of promoting blood circulation, removing blood stasis, reducing swelling, relieving cough, and calming asthma. It is mainly used to treat blood stasis syndromes, such as amenorrhea, dysmenorrhea, postpartum abdominal pain due to blood stasis, abdominal masses, and injuries from falls. It can treat constipation due to intestinal dryness, especially suitable for the elderly or those with blood deficiency and fluid depletion. It can be used for cough and asthma, especially those with phlegm and blood stasis or lung dryness. It can also treat early-stage lung abscess and intestinal abscess due to blood stasis and heat stagnation. Modern research shows that peach kernel has an inhibitory effect on acute and chronic inflammation and can relieve pain and cough. Its amygdalin content can increase liver blood flow, enhance collagenase activity, and reduce liver fibrosis, making it useful as an adjunct treatment for early-stage cirrhosis.

[0034] Scrophularia: Sweet, bitter, and salty in taste, slightly cold in nature, and enters the lung, stomach, and kidney meridians. It has the functions of clearing heat and cooling blood, nourishing yin and reducing fire, and detoxifying and dispersing nodules. It is mainly used to treat high fever, delirium, rashes, and crimson tongue caused by heat entering the blood level in febrile diseases; bone steaming fever, night sweats, dry throat and mouth, and constipation due to fluid depletion caused by yin deficiency and fire excess; sore throat, diphtheria, scrofula, carbuncles, and boils; constipation due to yin deficiency and intestinal dryness; and can assist in treating bleeding disorders such as hematemesis and epistaxis. Modern research shows that the active ingredients in Scrophularia, iridoid glycosides and phenylpropanoid glycosides, can inhibit various bacteria, viruses, and acute and chronic inflammatory responses. At the same time, polysaccharides and phenylpropanoid glycosides can promote lymphocyte proliferation and enhance the phagocytic capacity of macrophages.

[0035] Red peony root: Bitter in taste, slightly cold in nature, it enters the liver meridian and also the spleen meridian. It has the functions of clearing heat and cooling blood, dispersing blood stasis and relieving pain. It is mainly used to treat high fever, rashes, hematemesis, epistaxis, delirium, convulsions, and mania caused by heat entering the blood level in febrile diseases; amenorrhea, dysmenorrhea, postpartum abdominal pain due to blood stasis, masses and accumulations, and injuries from falls; red and swollen eyes, hypochondriac pain, carbuncles and sores, rheumatic pain, and headache, red eyes, and dizziness caused by liver fire. Modern research shows that paeoniflorin contained in red peony root has anti-inflammatory, analgesic, immunomodulatory, hepatoprotective, and microcirculation-improving effects. Meanwhile, quercetin and kaempferol can scavenge free radicals, have antioxidant, antitumor, antibacterial, and antiviral effects, while gallic acid and catechins can also have anti-inflammatory, hemostatic, antibacterial, and wound-healing effects, exhibiting strong inhibitory effects on inflammation and various types of blood stasis.

[0036] Bupleurum chinense (Northern Bupleurum): Bitter and pungent in taste, slightly cold in nature, and enters the liver, gallbladder, and lung meridians. It has the functions of dispersing and reducing fever, soothing the liver and relieving depression, raising yang qi, and reducing fever and stopping malaria. It is mainly used to treat exogenous fever, alternating chills and fever, colds, malaria, chest and rib pain due to liver qi stagnation, emotional depression, irregular menstruation, breast hyperplasia, rectal prolapse, uterine prolapse, gastroptosis, chronic diarrhea caused by qi deficiency, as well as Shaoyang syndrome such as bitter taste in the mouth, dry throat, and dizziness. Modern research shows that the saikosaponins contained in Bupleurum chinense have anti-inflammatory effects: inhibiting the NF-κB and MAPK pathways, reducing inflammatory factors such as TNF-α and IL-6, and also inhibiting influenza virus, HBV, HCV, and herpes virus. Its volatile oils, such as thujone, limonene, and β-caryophyllene, have antipyretic, analgesic, sedative, anticonvulsant, bronchodilator, and respiratory inflammation-improving effects.

[0037] Platycodon grandiflorum: Bitter and pungent in taste, neutral in property, attributing to the lung meridian. It has the functions of dispersing the lung qi, resolving phlegm, relieving sore throat and expelling pus. It is mainly used for treating excessive phlegm and cough, and can be combined with other herbs for treating wind-cold or wind-heat. It can treat swelling pain and hoarseness (such as acute and chronic pharyngitis, tonsillitis), lung abscess (pulmonary abscess) with expectoration of pus and blood, or non-ulceration of skin ulcers with pus formation. It can also be used as a "guide drug" to lead the effects of other herbs to the upper jiao and improve the curative effect of treating throat and lung diseases. Modern research shows that platycodin contained in Platycodon grandiflorum can resolve phlegm and relieve cough, stimulate the secretion of bronchial mucosa, dilute phlegm, inhibit the cough center reflex, and also has anti-inflammatory effects, blocking the NF-κB and MAPK pathways, reducing inflammatory factors such as TNF-α and IL-6. Flavonoids such as quercetin and kaempferol can antibacterial and antiviral, and have inhibitory effects on Staphylococcus aureus, influenza virus, etc.

[0038] Fried Licorice Root: Sweet in taste, neutral in property, attributing to the heart, lung, spleen and stomach meridians. It has the functions of invigorating the spleen and replenishing qi, clearing heat and detoxifying, resolving phlegm and relieving cough. It is mainly used for treating weakness of the spleen and stomach, lassitude, anorexia and loose stools, palpitation and intermittent pulse caused by deficiency of qi and blood, spasm and pain in the epigastrium or extremities, reducing the toxicity or potency of other herbs in the formula, and can also be used for consumptive cough, shortness of breath and less phlegm. Modern research shows that the triterpenoid saponins contained in Licorice Root have anti-inflammatory effects.

[0039] Raw Rehmannia Root: Sweet in taste, cold in property, attributing to the heart, liver and kidney meridians. It has the functions of clearing heat and cooling blood, nourishing yin and promoting fluid production. It is mainly used for treating high fever, coma, maculae, hematemesis, epistaxis caused by the invasion of pathogenic heat into nutrient qi and blood aspects in warm diseases, dry mouth and throat, thirst, crimson tongue, constipation due to fluid injury, and hematemesis, epistaxis, hematuria, metrorrhagia and metrostaxis caused by reckless flow of blood heat. Modern research shows that the iridoids and rehmannia polysaccharides contained in Raw Rehmannia Root can anti-inflammatory, inhibit the NF-κB and MAPK pathways, and reduce TNF-α and IL-6.

[0040] Immature Bitter Orange: Bitter, pungent and sour in taste, slightly cold in property, attributing to the spleen and stomach meridians. It has the functions of regulating qi and relieving fullness, promoting qi movement and resolving distension. It is mainly used for treating distending pain in the chest and hypochondrium, epigastrium and abdomen, qi stagnation of the spleen and stomach, indigestion, constipation, tenesmus after diarrhea, retention of phlegm-fluid and stuffiness and fullness in the chest diaphragm. Combined with Rhizoma Cimicifugae and Radix Bupleuri, it can treat organ prolapse, such as gastroptosis, rectal prolapse, uterine prolapse, etc. Modern research shows that its active ingredients such as naringin, hesperidin, neohesperidin, etc. can anti-inflammatory, anti-allergic, inhibit the NF-κB and MAPK pathways, and relieve acute and chronic inflammation.

[0041] Angelica sinensis: Sweet and pungent in taste, warm in property, attributing to the liver, heart and spleen meridians. It has the functions of promoting blood circulation and tonifying blood, regulating menstruation and relieving pain. It is mainly used for treating sallow complexion due to blood deficiency, dizziness and palpitation, scanty menstruation, amenorrhea, irregular menstruation, dysmenorrhea, abdominal pain due to postpartum blood stasis, constipation due to blood deficiency in the intestine, abdominal pain due to deficiency-cold, rheumatic arthralgia, injury from falls and fractures, carbuncles and ulcers, etc. Modern research shows that its ligustilide, flavonoids, coumarins, phthalides, etc. have anti-inflammatory, anti-tumor and other effects, and can treat recurrent respiratory tract infections.

[0042] Magnolia flower bud: pungent in taste and warm in nature, it enters the lung and stomach meridians, and has the functions of dispelling wind-cold and clearing nasal passages. It is mainly used to treat colds due to wind-cold, headaches, chills, nasal congestion and runny nose, sinusitis (acute and chronic rhinitis), allergic rhinitis, nasal congestion and loss of smell, headaches, toothaches, and supraorbital neuralgia caused by wind-cold. Modern research shows that its volatile oils, such as citral, eucalyptol, and eugenol, have anti-inflammatory and antibacterial properties, inhibiting common pathogenic bacteria such as Staphylococcus aureus and Streptococcus pneumoniae. They can also constrict nasal mucosal blood vessels, improve ventilation, reduce secretions, and relieve nasal congestion. Simultaneously, its magnolol content can fight allergies, inhibit mast cell degranulation and histamine release, and reduce allergic rhinitis symptoms.

[0043] Angelica dahurica: Pungent in flavor and warm in nature, it enters the lung, stomach, and large intestine meridians. It has the functions of relieving exterior syndromes and dispelling cold, dispelling wind and relieving pain, clearing nasal passages, reducing swelling and draining pus. It is mainly used to treat the initial stage of wind-cold common cold, chills and fever, headache and nasal congestion, Yangming headache (forehead and supraorbital neuralgia), toothache, rheumatic pain, sinusitis (acute and chronic), nasal congestion and runny nose due to allergic rhinitis, and sores and carbuncles, which can resolve in the early stages and promote pus drainage after ulceration. Modern research shows that its volatile oils, such as limonene, phellandrene, and anethole, have anti-inflammatory, analgesic, and antibacterial effects. They can inhibit Staphylococcus aureus and Escherichia coli, constrict nasal mucosal blood vessels, and rapidly improve nasal congestion.

[0044] Chuanxiong (Ligusticum striatum): Pungent in taste and warm in nature, it enters the liver, gallbladder, and pericardium meridians. It has the functions of promoting blood circulation, regulating qi, dispelling wind, and relieving pain. It is mainly used to treat menstrual disorders, dysmenorrhea, amenorrhea, postpartum abdominal pain due to blood stasis and qi stagnation, abdominal masses, chest and rib pain, headaches, migraines, rheumatic pain, and pain from falls and injuries caused by wind-cold, wind-heat, or blood stasis; chest pain, rib pain, and early-stage or chronic non-healing carbuncles and sores. Modern research shows that Chuanxiong has anti-inflammatory, analgesic, and antispasmodic effects, and has a significant relieving effect on migraines and dysmenorrhea models. It can also synergistically improve cerebral blood flow and inhibit smooth muscle spasms.

[0045] Xanthium sibiricum: It has a pungent and bitter taste, is warm in nature, and enters the lung meridian. It functions to dispel wind-cold, clear nasal passages, dispel wind-dampness, and relieve pain and itching. It is mainly used to treat headaches, nasal congestion, and anhidrosis caused by wind-cold common cold; sinusitis; acute and chronic sinusitis; nasal congestion and runny nose, and frontal headache caused by allergic rhinitis; and joint pain and limb contractures caused by wind-cold-dampness syndrome. Modern research shows that Xanthium sibiricum has antibacterial, anti-inflammatory, vasoconstrictive, nasal congestion-relieving, anti-allergic, mast cell degranulation-inhibiting, and alleviating allergic rhinitis symptoms.

[0046] Cat's Claw Herb: Sweet and pungent in taste, neutral in nature, it enters the liver and lung meridians. It has the functions of resolving phlegm and dissipating nodules, detoxifying and reducing swelling, and relieving malaria and pain. It is mainly used to treat scrofula, phlegm nodules, thyroid nodules, and breast hyperplasia, as well as carbuncles, boils, and insect and snake bites. Modern research shows that the caffeic acid and chlorogenic acid contained in Cat's Claw Herb have antibacterial and antiviral properties, synergistically enhancing the body's anti-infection ability.

[0047] Astragalus: Sweet in taste and slightly warm in nature, it enters the spleen and lung meridians. It has the functions of tonifying qi and raising yang, consolidating the exterior and stopping sweating, promoting diuresis and reducing edema, and generating fluids and nourishing blood. It is mainly used to treat spleen qi deficiency with poor appetite, loose stools, fatigue, and weakness; chronic diarrhea, rectal prolapse, and uterine prolapse due to qi sinking; spontaneous sweating and night sweats due to exterior deficiency; edema and difficulty urinating due to qi deficiency and water retention; internal heat and thirst; blood deficiency and chlorosis; numbness and pain; and hemiplegia. Modern research shows that astragalus can treat recurrent respiratory infections, enhance immunity, and reduce the incidence of infection.

[0048] Based on the theory of "opening, closing, and pivoting of the three Yin and three Yang," and using the method of "regulating the pivot, resolving stasis, and reducing swelling," this formula innovatively provides another diagnostic and treatment approach for the treatment of adenoid hypertrophy in children using traditional Chinese medicine. It serves as a reference for a wide range of pediatric clinicians. The prescription and medication of this formula are scientific and reasonable. Through the understanding and further application of "opening, closing, and pivoting of the three Yin and three Yang" in the Yellow Emperor's Inner Classic, it demonstrates the flexibility and practicality of traditional medicine in modern pediatric applications. It can further deepen the understanding of the treatment of adenoid hypertrophy in children using traditional Chinese medicine from both theoretical and practical clinical efficacy perspectives.

[0049] 2. This formula focuses on "holistic conditioning and syndrome differentiation and treatment," aiming to fundamentally improve the child's constitution, alleviate symptoms, and reduce recurrence. It reduces the blockage of the posterior nasal cavity by the adenoids, relieving primary symptoms such as nasal congestion, mouth breathing, and snoring during sleep. It also reduces the involvement of adjacent organs, lessens the impact of adenoid inflammation on the Eustachian tube and sinuses, and reduces the frequency of otitis media (ear pain, hearing loss) and sinusitis (purulent nasal discharge, headache), providing comprehensive protection for the child's quality of life after treatment.

[0050] 3. Compared to long-term use of nasal corticosteroids (such as mometasone furoate) or antibiotics, this formula has the advantage of being "primarily natural medicine with fewer systemic side effects": For children requiring long-term symptom control, this formula can reduce the frequency of corticosteroid use (e.g., changing from "daily nasal spray" to "every other day nasal spray"), reducing local side effects such as nasal dryness and nosebleeds, making it especially suitable for young children with poor tolerance to corticosteroids. It can also reduce antibiotic overuse, lower the probability of recurrent adenoid infections by regulating immunity, reduce repeated antibiotic use due to the vicious cycle of "inflammation-hyperplasia," and reduce the risk of drug resistance.

[0051] Typical case: Case 1: Patient Fan, male, 5 years and 11 months old, presented with intermittent, mouth-breathing snoring for one year prior to consultation without any obvious cause. Electronic nasopharyngoscopy revealed pale and swollen nasal septum, no significant septal deviation, bilateral inferior and middle turbinate enlargement, watery discharge in both nasal cavities, and enlarged adenoids in the nasopharynx, obstructing approximately 70% of the posterior nasal openings with visible watery discharge. Adenoid hypertrophy was diagnosed. After repeated ineffective treatments, he took the traditional Chinese medicine prepared according to this invention, 100ml daily for one month as one course of treatment. After three courses, his nighttime snoring significantly improved, and mouth breathing ceased. A follow-up nasopharyngoscopy revealed: nasal septum roughly centered, no abnormal discharge or new growths observed; nasopharynx: enlarged adenoids, obstructing approximately 50% of the posterior nasal openings. No recurrence to date.

[0052] Case 2: Patient Sun, female, 4 years and 11 months old, presented with intermittent mouth breathing, noisy breathing at night, nasal congestion, occasional runny nose, and occasional snoring four months prior to consultation. Electronic nasopharyngoscopy revealed adenoid hypertrophy and rhinitis. The nasal septum was roughly midline, and watery secretions were observed in both nasal cavities. No abnormal growths were found in either nasal passage. Adenoid hypertrophy was found in the nasopharynx, obstructing approximately 80% of the posterior nasal opening, and compression of the pharyngeal orifice of the Eustachian tube, confirming the diagnosis of adenoid hypertrophy. After repeated ineffective treatments, she took the traditional Chinese medicine prepared according to this invention, 100ml daily, for one month as one course of treatment. After three courses, the mouth breathing and snoring symptoms largely disappeared. A follow-up nasopharyngoscopy revealed adenoid hypertrophy in the nasopharynx, obstructing approximately 55% of the posterior nasal opening. She has not relapsed to date.

[0053] Case 3: Liao, female, 8 years old. Nasopharyngoscopy revealed sinusitis and 85% adenoid hypertrophy. Her parents reported snoring during sleep, mouth breathing, nasal speech, and increased nasal discharge. She was diagnosed with adenoid hypertrophy. She was prescribed the herbal medicine prepared according to this invention, 200ml daily, divided into two doses (morning and evening) dissolved in hot water. One month constituted one course of treatment. After one course, the adenoid hypertrophy symptoms lessened. A follow-up electronic nasopharyngoscopy showed: nasal cavity: bilateral nasal cavities were patent, nasal septum was roughly centered, and no abnormal secretions or new growths were observed. Nasopharynx: mucosa was smooth, bilateral pharyngeal recesses were symmetrical with bulges, and the posterior nasal opening was approximately 50% blocked; the occipital orifice was normal in shape. She was cured after three courses of treatment and has not relapsed to date.

[0054] A method for preparing a traditional Chinese medicine for treating adenoid hypertrophy in children, such as Figure 1 As shown, the method includes the following steps: S01: Material Selection and Proportioning: Select medicinal materials according to the above-mentioned traditional Chinese medicine prescription for treating adenoid hypertrophy in children, ensuring that they are free from insects, mold, and mildew, and weigh and verify the compatibility ratio according to the prescription. S02: Drying and coarse grinding: Place the medicinal materials in a cool, ventilated place to dry thoroughly; first use a pulverizer to initially crush them to facilitate subsequent fine grinding; then use an ultra-fine pulverizer to grind the medicinal materials into a fine powder, ensuring that the powder is uniform and free of particles. S03: Sieving and mixing: Filter the powder through an 80-100 mesh sieve, and re-grind any coarse particles that do not pass through the sieve. When mixing, stir in batches using an equal-increment method to ensure uniform distribution. S04: Sterilization treatment: Spread the powder evenly in a sterilization container and irradiate with ultraviolet light for 30 minutes. S05: Packaging and Storage: Pack the contents into a sterilized, light-proof bag, label it with the name, date, and usage instructions; store in a cool, dry place, and check regularly for moisture and clumping. This invention addresses the key pathogenesis of adenoid hypertrophy, namely "blood stasis and obstruction of the central mechanism," and adopts the principle of "regulating the central mechanism, resolving blood stasis and reducing swelling." Furthermore, it adjusts the formula based on the four major clinical syndrome types. Long-term clinical research and practice have demonstrated significant efficacy, minimal side effects, and reliable safety. It provides guidance for the diagnosis and treatment of adenoid hypertrophy in children with AH and is an effective drug for treating adenoid hypertrophy in children, especially those with blood stasis.

[0055] A traditional Chinese medicine powder for treating adenoid hypertrophy in children, the powder being prepared using the method described above for preparing traditional Chinese medicine for treating adenoid hypertrophy in children.

[0056] It should be understood that those skilled in the art can make improvements or modifications based on the above description, and all such improvements and modifications should fall within the protection scope of the appended claims.

Claims

1. A traditional Chinese medicine formula for treating adenoid hypertrophy in children, characterized in that, The formula includes the following ingredients: peach kernel 3-5g, safflower 3-5g, scrophularia 1-3g, red peony root 1-3g, bupleurum root 1-3g, platycodon root 1-3g, prepared licorice root 1-3g, rehmannia root 5-8g, immature bitter orange peel 1-3g, angelica root 1-3g, magnolia flower 3-5g, angelica dahurica root 3-5g, chuanxiong rhizome 1-3g, cocklebur fruit 1-3g, cat's claw herb 3-5g, and astragalus root 3-5g.

2. The traditional Chinese medicine formula for treating adenoid hypertrophy in children according to claim 1, characterized in that, The ingredients include 5g of peach kernel, 5g of safflower, 2g of scrophularia, 3g of red peony root, 2g of bupleurum root, 3g of platycodon root, 3g of prepared licorice root, 8g of rehmannia root, 3g of immature bitter orange peel, 3g of angelica root, 5g of magnolia flower, 5g of angelica dahurica, 3g of chuanxiong rhizome, 3g of cocklebur fruit, 5g of cat's claw herb, and 5g of astragalus root.

3. The traditional Chinese medicine formula for treating adenoid hypertrophy in children according to claim 1, characterized in that, The ingredients include 3g of peach kernel, 5g of safflower, 2g of scrophularia, 2g of red peony root, 2g of bupleurum root, 3g of platycodon root, 2g of prepared licorice root, 8g of rehmannia root, 3g of immature bitter orange peel, 3g of angelica root, 5g of magnolia flower, 5g of angelica dahurica, 3g of chuanxiong rhizome, 3g of cocklebur fruit, 3g of cat's claw herb, and 5g of astragalus root.

4. The traditional Chinese medicine formula for treating adenoid hypertrophy in children according to claim 1, characterized in that, The ingredients include 3g of peach kernel, 3g of safflower, 1g of scrophularia, 2g of red peony root, 2g of bupleurum root, 3g of platycodon root, 2g of prepared licorice root, 6g of rehmannia root, 2g of immature bitter orange peel, 2g of angelica root, 4g of magnolia flower, 4g of angelica root, 2g of chuanxiong rhizome, 2g of cocklebur fruit, 5g of cat's claw herb, and 3g of astragalus root.

5. The traditional Chinese medicine formula for treating adenoid hypertrophy in children according to claim 1, characterized in that, The ingredients include 5g of peach kernel, 3g of safflower, 1g of scrophularia, 2g of red peony root, 3g of bupleurum root, 3g of platycodon root, 3g of prepared licorice root, 6g of rehmannia root, 2g of immature bitter orange peel, 2g of angelica root, 4g of magnolia flower, 4g of angelica dahurica, 3g of chuanxiong rhizome, 2g of cocklebur fruit, 3g of cat's claw herb, and 5g of astragalus root.

6. The traditional Chinese medicine formula for treating adenoid hypertrophy in children according to claim 1, characterized in that, The ingredients include 5g of peach kernel, 4g of safflower, 2g of scrophularia, 1g of red peony root, 3g of bupleurum root, 3g of platycodon root, 3g of prepared licorice root, 6g of rehmannia root, 2g of immature bitter orange peel, 2g of angelica root, 3g of magnolia flower, 3g of angelica dahurica, 1g of chuanxiong rhizome, 1g of cocklebur fruit, 3g of cat's claw herb, and 5g of astragalus root.

7. The traditional Chinese medicine formula for treating adenoid hypertrophy in children according to claim 1, characterized in that, The ingredients include 4g of peach kernel, 4g of safflower, 2g of scrophularia, 3g of red peony root, 1g of bupleurum root, 2g of platycodon root, 1g of prepared licorice root, 6g of rehmannia root, 3g of immature bitter orange peel, 1g of angelica root, 3g of magnolia flower, 5g of angelica dahurica, 2g of chuanxiong rhizome, 2g of cocklebur fruit, 5g of cat's claw herb, and 3g of astragalus root.

8. The traditional Chinese medicine formula for treating adenoid hypertrophy in children according to claim 1, characterized in that, The ingredients include 4g of peach kernel, 5g of safflower, 3g of scrophularia, 1g of red peony root, 1g of bupleurum root, 1g of platycodon root, 3g of prepared licorice root, 6g of rehmannia root, 1g of immature bitter orange peel, 3g of angelica root, 5g of magnolia flower, 3g of angelica dahurica, 3g of chuanxiong rhizome, 1g of cocklebur fruit, 4g of cat's claw herb, and 4g of astragalus root.

9. A method for preparing a traditional Chinese medicine for treating adenoid hypertrophy in children, characterized in that, The method includes the following steps: Material selection and proportioning: The medicinal materials for the treatment of adenoid hypertrophy in children according to any one of claims 1-8 shall be selected to ensure that they are free from insects and mold, and shall be weighed and the proportions verified according to the prescription. Drying and coarse grinding: Place the medicinal materials in a cool and ventilated place to dry thoroughly; first use a pulverizer to perform preliminary crushing to facilitate subsequent fine grinding; Fine grinding: Use an ultra-fine pulverizer to grind the medicinal materials into fine powder, requiring the powder to be uniform and free of particles; Sieving and mixing: Filter the powder through an 80-100 mesh sieve, and re-grind any coarse particles that are not sieved; when mixing, stir in batches using an equal-increment method to ensure uniform distribution; Sterilization treatment: Spread the powder evenly in a sterilization container and irradiate with ultraviolet light for 30 minutes; Packaging and storage: Pack into sterilized light-proof bags, label with name, date and usage; store in a cool, dry place, and check regularly for moisture and clumping.

10. A traditional Chinese medicine powder for treating adenoid hypertrophy in children, characterized in that, The traditional Chinese medicine powder is prepared by the method for preparing traditional Chinese medicine for treating adenoid hypertrophy in children as described in claim 9.

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