Medical oral anti-caries gel for preventing tooth decay and promoting healthy teeth and a preparation method thereof

Abstract

This invention relates to a medical oral cavity-preventing gel for preventing tooth decay and promoting tooth health, and its preparation method, belonging to the field of oral care technology. The gel components include: sodium fluoride, zinc citrate, sodium lauryl sulfate-modified silica, sodium lauryl sulfate, sodium benzoate, sorbitol, peppermint flavor, glycerin, sodium carboxymethyl cellulose, xanthan gum, and deionized water. The preparation method includes steps such as preparing activated silica, mixing the components, heating and holding at a constant temperature, and adding excipients after cooling. This invention enhances the adsorption capacity of silica by coating it with sodium lauryl sulfate, synergistically achieving multi-target anti-caries effects through the remineralization of sodium fluoride and the antibacterial properties of zinc citrate. Furthermore, a staged temperature-controlled process optimizes component stability, significantly prolonging the fluoride retention time on the tooth surface and improving the anti-caries effect.

Description

Technical Field

[0001] This invention belongs to the field of oral care technology and relates to a medical oral cavity prevention gel for preventing tooth decay and promoting healthy teeth, and its preparation method. Background Technology

[0002] Oral health is an important component of overall health, and dental caries, as one of the most common oral diseases, seriously affects people's quality of life. To effectively prevent dental caries, fluoride oral care products have become the mainstream choice. Fluoride significantly reduces the incidence of dental caries by enhancing the acid resistance of tooth enamel, promoting remineralization of early caries lesions, and inhibiting the activity of cariogenic bacteria. Currently, fluoride toothpaste, mouthwash, and gels are widely used in daily oral care. Among them, fluoride gels, due to their ability to form a high fluoride concentration locally, are considered an effective intervention for high-risk groups. Their usage and formulation design directly affect their caries-preventing effect.

[0003] However, existing fluoride oral care products still have significant limitations. On the one hand, fluoride ions have a short retention time in the oral cavity. Due to factors such as saliva rinsing and swallowing, most fluoride ions are removed before fully interacting with the tooth surface, resulting in low utilization. On the other hand, the anti-caries effect of a single fluoride is limited and it is difficult to cope with the complex oral microenvironment. Especially when cariogenic bacteria proliferate in large numbers and dental plaque continues to form, its inhibitory effect is often not long-lasting enough to fundamentally break the chain of tooth decay. These problems mean that even with long-term use of fluoride products, some people still face a high risk of tooth decay.

[0004] To address the aforementioned issues, existing research has attempted to enhance caries prevention by combining fluoride with other ingredients, such as antibacterial agents and minerals. However, many current formulations suffer from insignificant effects or poor stability. Furthermore, abrasives commonly used in oral care products, such as silica, are typically only assigned basic functions like cleaning tooth surfaces and adjusting product texture; their potential as functional carriers has not been fully explored, failing to play a positive role in enhancing fluoride ion retention and improving ingredient utilization. Summary of the Invention

[0005] The purpose of this invention is to provide a medical oral cavity-preventing gel for preventing tooth decay and promoting healthy teeth, and a method for preparing the same. This invention prepares a caries-preventing product that prolongs the retention time of fluoride on the tooth surface and achieves long-lasting caries prevention through the continuous release of fluoride ions.

[0006] The objective of this invention can be achieved through the following technical solutions:

[0007] A medical oral cavity-preventing gel for preventing tooth decay and promoting healthy teeth comprises the following components by weight percentage: sodium fluoride 0.01-0.5%, zinc citrate 0.01-0.5%, sodium lauryl sulfate-modified silica 1-20%, sodium lauryl sulfate 0.1-5%, sodium benzoate 0.01-0.5%, sorbitol 1-60%, peppermint flavor 0.01-2%, glycerin 1-30%, sodium carboxymethyl cellulose 0.01-1%, xanthan gum 0.01-1%, and the balance being deionized water.

[0008] Furthermore, the preparation method of the aforementioned anti-caries oral care gel includes the following steps:

[0009] (1) Mix silicon dioxide and sodium dodecyl sulfate evenly in deionized water, filter and dry to obtain activated silicon dioxide;

[0010] (2) Mix glycerin, sodium carboxymethyl cellulose, xanthan gum, and sorbitol evenly;

[0011] (3) Add the remaining deionized water, sodium fluoride, zinc citrate, activated silica prepared in step (1), and sodium dodecyl sulfate to the mixture in step (2);

[0012] (4) Stir the mixture obtained in step (3) and heat it to 80-90℃, and keep it at that temperature for 15-25 minutes;

[0013] (5) After keeping the product warm in step (4), stir and cool it to 35-45℃, add sodium benzoate and peppermint flavoring and mix evenly to obtain the final product.

[0014] In this application, sodium dodecyl sulfate forms non-covalent bonds with the silanol groups on the surface of silica, with the hydrophilic sulfate ions facing the aqueous phase, creating a locally negatively charged microenvironment within the gel, which generates a weak electrostatic attraction with fluoride ions; simultaneously, the silanol groups on the silica surface coordinate with fluoride ions... - Combined. Under neutral pH conditions in the oral cavity, the shielding effect of salivary electrolytes is weak, F - Due to the slow release through diffusion, the coating structure of sodium dodecyl sulfate delays the degradation of the gel matrix, ultimately prolonging the retention time of fluoride ions on the tooth surface.

[0015] As a preferred technical solution of the present invention, in step (1), the mass ratio of silicon dioxide, sodium dodecyl sulfate and deionized water is 10: 0.1-0.5: 100-200.

[0016] As a preferred technical solution of the present invention, the mixing temperature in step (1) is 25-40℃, and the mixture is stirred at a speed of 100-500r / min for 10-60min.

[0017] As a preferred technical solution of the present invention, the particle size of the activated silica in step (1) is 5-50 μm.

[0018] As a preferred technical solution of the present invention, the heating rate in step (4) is 1-3°C per minute.

[0019] As a preferred technical solution of the present invention, the cooling rate in step (5) is 0.5-2℃ per minute.

[0020] Furthermore, the application of the aforementioned medical oral cavity-preventing gel for preventing tooth decay and promoting healthy teeth in the preparation of anti-caries agents that prolong the fluoride retention time on the tooth surface.

[0021] The beneficial effects of this invention are:

[0022] (1) In this invention, sodium dodecyl sulfate is used to coat silica. The hydrophilic sulfonic acid group of sodium dodecyl sulfate interacts with the aqueous phase and the hydrophobic alkyl group is adsorbed on the surface of silica to form a stable coating layer. This not only enhances the physical adsorption of fluoride ions by silica, but also enhances the adhesion of the gel to the tooth surface, prolongs the retention time of fluoride ions on the tooth surface, prolongs the remineralization time of fluoride ions on tooth enamel, and improves the anti-caries efficacy.

[0023] (2) In this invention, sodium fluoride and zinc citrate work synergistically. Sodium fluoride promotes the regeneration of hydroxyapatite crystals in tooth enamel to achieve remineralization. Zinc citrate inhibits the metabolic activities of cariogenic bacteria such as Streptococcus mutans and reduces the secretion of extracellular polysaccharides, thereby blocking the acid erosion of tooth enamel by dental plaque. The two work synergistically, breaking through the limitations of single fluoride and forming a dual-effect anti-caries system that repairs and prevents caries. Detailed Implementation

[0024] To further illustrate the technical means and effects of the present invention in achieving its intended purpose, the following detailed description of the specific implementation methods, structures, features, and effects of the present invention, in conjunction with embodiments, is provided below.

[0025] Example 1

[0026] A medical oral cavity-preventing gel for preventing tooth decay and promoting healthy teeth comprises the following components by weight percentage: 0.25% sodium fluoride, 0.25% zinc citrate, 10% sodium lauryl sulfate-modified silica, 2.5% sodium lauryl sulfate, 0.25% sodium benzoate, 30% sorbitol, 1% peppermint flavor, 15% glycerin, 0.5% sodium carboxymethyl cellulose, 0.5% xanthan gum, and the balance being deionized water.

[0027] The preparation method of the aforementioned anti-caries oral care gel includes the following steps:

[0028] (1) Mix silicon dioxide and sodium dodecyl sulfate evenly in deionized water, filter and dry to obtain activated silicon dioxide;

[0029] (2) Mix glycerin, sodium carboxymethyl cellulose, xanthan gum, and sorbitol evenly;

[0030] (3) Add the remaining deionized water, sodium fluoride, zinc citrate, activated silica prepared in step (1), and sodium dodecyl sulfate to the mixture in step (2);

[0031] (4) Stir the mixture obtained in step (3) and heat it to 85°C, then keep it at that temperature for 20 minutes;

[0032] (5) Stir and cool down to 40°C, then add sodium benzoate and peppermint flavoring and mix well to obtain the final product.

[0033] Step (1) The mass ratio of silicon dioxide, sodium dodecyl sulfate and deionized water is 10:0.3:150.

[0034] The mixing temperature in step (1) is 32°C, and the mixture is stirred at 300 r / min for 40 min.

[0035] The particle size of the activated silica in step (1) is 5-50 μm.

[0036] The heating rate in step (4) is 2°C per minute.

[0037] The cooling rate in step (5) is 1.5°C per minute.

[0038] The application of the aforementioned medical oral cavity-preventing gel for preventing tooth decay and promoting tooth health in the preparation of anti-caries agents that prolong the fluoride retention time on the tooth surface.

[0039] Example 2

[0040] A medical oral cavity-preventing gel for preventing tooth decay and promoting healthy teeth comprises the following components by weight percentage: 0.25% sodium fluoride, 0.25% zinc citrate, 10% sodium lauryl sulfate-modified silica, 2.5% sodium lauryl sulfate, 0.25% sodium benzoate, 30% sorbitol, 1% peppermint flavor, 15% glycerin, 0.5% sodium carboxymethyl cellulose, 0.5% xanthan gum, and the balance being deionized water.

[0041] The preparation method of the aforementioned anti-caries oral care gel includes the following steps:

[0042] (1) Mix silicon dioxide and sodium dodecyl sulfate evenly in deionized water, filter and dry to obtain activated silicon dioxide;

[0043] (2) Mix glycerin, sodium carboxymethyl cellulose, xanthan gum, and sorbitol evenly;

[0044] (3) Add the remaining deionized water, sodium fluoride, zinc citrate, activated silica prepared in step (1), and sodium dodecyl sulfate to the mixture in step (2);

[0045] (4) Stir the mixture obtained in step (3) and heat it to 80°C, then keep it at that temperature for 15 minutes;

[0046] (5) After keeping the product warm in step (4), stir and cool it to 35°C. Add sodium benzoate and peppermint flavoring and mix evenly to obtain the final product.

[0047] Step (1) The mass ratio of silicon dioxide, sodium dodecyl sulfate and deionized water is 10:0.1:100.

[0048] The mixing temperature in step (1) is 25°C, and the mixture is stirred at 100 r / min for 10 min.

[0049] The particle size of the activated silica in step (1) is 5-50 μm.

[0050] The heating rate in step (4) is 1°C per minute.

[0051] The cooling rate in step (5) is 0.5°C per minute.

[0052] The application of the aforementioned medical oral cavity-preventing gel for preventing tooth decay and promoting tooth health in the preparation of anti-caries agents that prolong the fluoride retention time on the tooth surface.

[0053] Example 3

[0054] A medical oral cavity-preventing gel for preventing tooth decay and promoting healthy teeth comprises the following components by weight percentage: 0.01% sodium fluoride, 0.01% zinc citrate, 1% sodium lauryl sulfate-modified silica, 0.1% sodium lauryl sulfate, 0.01% sodium benzoate, 60% sorbitol, 0.01% peppermint flavoring, 30% glycerin, 0.01% sodium carboxymethyl cellulose, 0.01% xanthan gum, with the balance being deionized water.

[0055] The preparation method of the aforementioned anti-caries oral care gel includes the following steps:

[0056] (1) Mix silicon dioxide and sodium dodecyl sulfate evenly in deionized water, filter and dry to obtain activated silicon dioxide;

[0057] (2) Mix glycerin, sodium carboxymethyl cellulose, xanthan gum, and sorbitol evenly;

[0058] (3) Add the remaining deionized water, sodium fluoride, zinc citrate, activated silica prepared in step (1), and sodium dodecyl sulfate to the mixture in step (2);

[0059] (4) Stir the mixture obtained in step (3) and heat it to 80°C, then keep it at that temperature for 15 minutes;

[0060] (5) After keeping the product warm in step (4), stir and cool it to 35°C. Add sodium benzoate and peppermint flavoring and mix evenly to obtain the final product.

[0061] Step (1) The mass ratio of silicon dioxide, sodium dodecyl sulfate and deionized water is 10:0.1:100.

[0062] The mixing temperature in step (1) is 25°C, and the mixture is stirred at 100 r / min for 10 min.

[0063] The particle size of the activated silica in step (1) is 5-50 μm.

[0064] The heating rate in step (4) is 1°C per minute.

[0065] The cooling rate in step (5) is 0.5°C per minute.

[0066] The application of the aforementioned medical oral cavity-preventing gel for preventing tooth decay and promoting tooth health in the preparation of anti-caries agents that prolong the fluoride retention time on the tooth surface.

[0067] Example 4

[0068] A medical oral cavity-preventing gel for preventing tooth decay and promoting healthy teeth comprises the following components by weight percentage: 0.5% sodium fluoride, 0.5% zinc citrate, 20% sodium dodecyl sulfate-modified silica, 5% sodium dodecyl sulfate, 0.5% sodium benzoate, 10% sorbitol, 2% peppermint flavoring, 10% glycerin, 1% sodium carboxymethyl cellulose, 1% xanthan gum, and the balance being deionized water.

[0069] The preparation method of the aforementioned anti-caries oral care gel includes the following steps:

[0070] (1) Mix silicon dioxide and sodium dodecyl sulfate evenly in deionized water, filter and dry to obtain activated silicon dioxide;

[0071] (2) Mix glycerin, sodium carboxymethyl cellulose, xanthan gum, and sorbitol evenly;

[0072] (3) Add the remaining deionized water, sodium fluoride, zinc citrate, activated silica prepared in step (1), and sodium dodecyl sulfate to the mixture in step (2);

[0073] (4) Stir the mixture obtained in step (3) and heat it to 90°C, then keep it at that temperature for 25 minutes;

[0074] (5) After keeping the product warm in step (4), stir and cool it to 45°C. Add sodium benzoate and peppermint flavoring and mix evenly to obtain the final product.

[0075] Step (1) The mass ratio of silicon dioxide, sodium dodecyl sulfate and deionized water is 10:0.5:200.

[0076] The mixing temperature in step (1) is 40°C, and the mixture is stirred at 500 r / min for 10-60 min.

[0077] The particle size of the activated silica in step (1) is 5-50 μm.

[0078] The heating rate in step (4) is 3°C per minute.

[0079] The cooling rate described in step (5) is 2°C per minute.

[0080] The application of the aforementioned medical oral cavity-preventing gel for preventing tooth decay and promoting tooth health in the preparation of anti-caries agents that prolong the fluoride retention time on the tooth surface.

[0081] Comparative Example 1

[0082] Based on Example 1, silica was used instead of sodium dodecyl sulfate-modified silica, while the rest remained the same as in Example 1.

[0083] Comparative Example 2

[0084] Based on Example 1, the sodium dodecyl sulfate-modified silica was replaced with sodium dodecyl sulfate-modified calcium carbonate, while the rest remained the same as in Example 1.

[0085] Comparative Example 3

[0086] Based on Example 1, zinc citrate was not added, but everything else remained the same as in Example 1.

[0087] Comparative Example 4

[0088] Based on Example 1, zinc citrate was replaced with zinc chloride, and the rest remained the same as in Example 1.

[0089] Comparative Example 5

[0090] Based on Example 1, sodium dodecyl sulfate was replaced with sodium dodecyl sulfonate, and the rest remained the same as in Example 1.

[0091] Comparative Example 6

[0092] Based on Example 1, sodium dodecyl sulfate was replaced with cocamidopropyl betaine, and the rest remained the same as in Example 1.

[0093] Comparative Example 7

[0094] Based on Example 1, the preparation method was changed to directly mix all components with 80°C for 40 minutes until homogeneous, while the rest remained the same as in Example 1.

[0095] Performance testing:

[0096] Fluoride retention test on tooth surface: Extracted bovine tooth enamel slides were used. The gels of the example and comparative examples were applied for 5 min. The slides were subjected to constant temperature oscillation at 37°C to simulate the dynamic oral environment. The samples were taken out at time intervals (0.5 h, 1 h, 2 h, 4 h, 8 h), and the sample surface was gently rinsed with deionized water. The surface fluoride ion concentration was detected according to ISO 19448:2018 standard.

[0097] Antibacterial test: 1×10⁻⁶ Streptococcus mutans (standard strain ATCC 25175) bacterial suspension was used. 5 The gels (CFU / mL) prepared in the examples and comparative examples (1:10 dilution) were mixed and anaerobically cultured at 37°C for 24 h. The pH change of the culture medium was detected (pH meter), and the acid production was calculated (ΔpH = initial pH - final pH). At the same time, the diameter of the inhibition zone was observed by the agar diffusion method to evaluate the inhibitory ability on cariogenic bacteria.

[0098]

[0099] The test results show that the examples obtained a long-lasting fluoride sustained-release and antibacterial gel through the synergistic effect of sodium dodecyl sulfate encapsulating activated silica, fluoride ions, and zinc citrate, and through a temperature-controlled preparation method. Comparative Example 1, with silica unmodified by sodium dodecyl sulfate, lacked an activation carrier and therefore had no sustained-release capacity; the burst release of fluoride ions resulted in insufficient local concentration, leading to a decreased antibacterial effect. Comparative Example 2, using calcium carbonate as a carrier, showed weak adsorption. Comparative Example 3, without the addition of zinc citrate, showed a significant decrease in antibacterial effect. Comparative Example 4, using zinc chloride instead of zinc citrate, resulted in excessively rapid zinc ion release and poor antibacterial effect, lacking citrate buffering. The effect of acid production is more obvious, and the decrease in the slow release effect of fluoride ions may be due to the competitive adsorption of chloride ions. In Comparative Example 5, sodium dodecyl sulfonate was used instead of sodium dodecyl sulfate. Since the sulfonate groups could not coat the silica, the slow release effect was greatly reduced. The cell membrane penetration of sulfonate was weaker than that of sulfate, and the antibacterial effect was also reduced. In Comparative Example 6, cocamidopropyl betaine was used instead of sodium dodecyl sulfate. The zwitterionic acid disrupted the charge balance of the carrier, and the slow release of fluoride was significantly reduced. The antibacterial effect was also extremely poor. In Comparative Example 7, the process was simplified and directly mixed. The overall performance may have been reduced due to the destruction of the mesoporous structure of the carrier by high temperature.

[0100] The above description is merely a preferred embodiment of the present invention and is not intended to limit the present invention in any way. Although the present invention has been disclosed above with reference to preferred embodiments, it is not intended to limit the present invention. Any person skilled in the art can make some modifications or alterations to the above-disclosed technical content to create equivalent embodiments without departing from the scope of the present invention. Any simple modifications, equivalent changes and alterations made to the above embodiments based on the technical essence of the present invention without departing from the scope of the present invention shall still fall within the scope of the present invention.

Claims

1. A medical oral cavity anti-caries gel for preventing caries and promoting tooth health, characterized by comprising: The composition by weight percentage includes: sodium fluoride 0.01-0.5%, zinc citrate 0.01-0.5%, sodium dodecyl sulfate modified silica 1-20%, sodium dodecyl sulfate 0.1-5%, sodium benzoate 0.01-0.5%, sorbitol 1-60%, peppermint flavor 0.01-2%, glycerin 1-30%, sodium carboxymethyl cellulose 0.01-1%, xanthan gum 0.01-1%, and the balance being deionized water; ​ The method for preparing sodium dodecyl sulfate modified silica is as follows: silica and sodium dodecyl sulfate are mixed evenly in deionized water, filtered and dried to obtain sodium dodecyl sulfate modified silica; The mass ratio of silicon dioxide, sodium dodecyl sulfate, and deionized water is 10: 0.1-0.5: 100-200.

2. A process for the preparation of the medical anti-caries and anti-plaque gel according to claim 1, characterized in that, Includes the following steps: (1) Mix silica and sodium dodecyl sulfate in deionized water until homogeneous, filter and dry to obtain silica modified with sodium dodecyl sulfate; (2) Mix glycerin, sodium carboxymethyl cellulose, xanthan gum, and sorbitol evenly; (3) Add deionized water, sodium fluoride, zinc citrate, sodium dodecyl sulfate-modified silica and sodium dodecyl sulfate obtained in step (1) to the mixture in step (2); (4) Stir the mixture obtained in step (3) and heat it to 80-90℃, and keep it at that temperature for 15-25 minutes; (5) After keeping the product warm in step (4), stir and cool it to 35-45℃, add sodium benzoate and peppermint flavoring and mix evenly to obtain the final product.

3. A process for the preparation of an anti-caries, dentifrice medical oral anti-caries gel as claimed in claim 2, wherein: The mixing temperature in step (1) is 25-40℃, and the mixture is stirred at 100-500 r / min for 10-60 min.

4. A process for the preparation of an anti-caries, dentifrice medical oral anti-caries gel as claimed in claim 2, wherein: The dodecyl sulfate-modified silica in step (1) has a particle size of 5-50 μm.

5. The method for preparing a medical oral cavity-preventing gel for preventing tooth decay and promoting healthy teeth according to claim 2, characterized in that: The heating rate in step (4) is 1-3°C per minute.

6. A process for the preparation of an anti-caries, dentifrice medical oral anti-caries gel as claimed in claim 2, wherein: The cooling rate in step (5) is 0.5-2℃ per minute.

7. The use of a medical oral cavity-preventing gel as described in claim 1 in the preparation of a caries-preventing preparation that prolongs the fluoride retention time on the tooth surface.

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