Full-automatic luminous immune blood gas analyzer

Abstract

The invention discloses a full-automatic light-emitting immune blood gas analyzer, and belongs to the technical field of blood detection.The analyzer comprises a sample loading module, a shake-up module and a blood gas module, the sample loading module comprises a sample disc, and the sample disc is provided with a bayonet used for being connected with a blood taking needle in a clamped mode; the shaking module comprises a first longitudinal displacement module, a first lifting displacement module, a first rotating module and a clamping jaw, the clamping jaw can clamp the blood taking needle in the bayonet, the first longitudinal displacement module and the first lifting displacement module can drive the blood taking needle to move in a first plane, and the first rotating module can shake the blood taking needle through the clamping jaw; the blood gas module is provided with a blood gas sampling needle capable of stretching out, and the blood gas sampling needle is located in a first plane. Compared with the prior art, the full-automatic light-emitting immune blood gas analyzer provided by the invention integrates the functions of a light-emitting immune blood gas analyzer and an immune blood gas analyzer, and two types of detection can be completed only by collecting one blood sample, so that the burden of a patient is relieved, the consumption of consumables is reduced, and the detection operation is simplified.

Description

Technical Field

[0001] This invention relates to the field of blood testing technology, specifically to a fully automated luminescent immunoassay blood gas analyzer. Background Technology

[0002] Immunoassay has evolved over half a century and has developed into many different types. Based on whether the analyte needs to be separated from the reaction system during the assay, it can be divided into heterogeneous immunoassay and homogeneous immunoassay. Heterogeneous immunoassay refers to the process where, after the various reagents are mixed and reacted during the introduction of a probe for labeling, separation is required to separate the analyte from the reaction system before detection. This is currently the mainstream method in immunoassay.

[0003] Homogeneous chemiluminescence immunoassay is a homogeneous immunological detection technique that uses acceptor beads and donor beads coated with biomolecules as carriers. This technique boasts high sensitivity, strong specificity, low background interference, low sample requirements, low cost, simple analytical operation, and a wide detection range. It is suitable for simple small molecule interactions that can be detected by traditional ELISA and other chemiluminescence techniques, and is also capable of high-throughput detection of complex macromolecular interactions.

[0004] Blood gas analyzers are mainly used to quickly detect indicators such as oxygen, carbon dioxide, acid-base balance, and electrolyte levels in the blood. They are used for clinical assessment to help patients evaluate respiratory function, metabolic status, internal environment stability, and severity. They are suitable for respiratory diseases, metabolic disorders, intensive care, surgical anesthesia, and emergency repairs.

[0005] Currently, chemiluminescence immunoassay analyzers and blood gas analyzers are two separate devices. During testing, two blood samples need to be collected and placed into the chemiluminescence immunoassay analyzer and the blood gas analyzer respectively. This increases both the burden on patients and the workload during testing. Summary of the Invention

[0006] The purpose of this invention is to overcome the above-mentioned technical deficiencies and propose a fully automated chemiluminescence immunoassay blood gas analyzer, which solves the technical problem that existing technologies require the use of two separate devices for chemiluminescence immunoassay and blood gas analysis.

[0007] To achieve the above-mentioned technical objectives, the present invention adopts the following technical solution: This invention provides a fully automated chemiluminescence immunoassay blood gas analyzer, comprising: a sample loading module, a mixing module, and a blood gas module. The sample loading module includes a sample tray, which has a snap-fit ​​for receiving a blood collection needle; The shaking module includes a first longitudinal displacement module, a first lifting displacement module, a first rotating module, and a gripper. The first longitudinal displacement module is driven to the first lifting displacement module, the first lifting displacement module is driven to the first rotating module, and the first rotating module is driven to the gripper. The gripper can grasp the blood collection needle in the slot. The first longitudinal displacement module and the first lifting displacement module can drive the blood collection needle to move in a first plane. The first rotating module can shake the blood collection needle via the gripper. The blood gas module has an extendable blood gas sampling needle located in the first plane; the first rotating module can rotate the blood collection needle toward the blood gas sampling needle, and the first longitudinal displacement module and the first lifting displacement module drive the blood collection needle to move toward the blood gas sampling needle.

[0008] In some embodiments, the sample loading module further includes a rotary module, which is connected to the sample tray to drive the sample tray to rotate; the sample tray has a sample placement position and a shaking position, when the sample tray is located in the sample placement position, it is used to place a blood collection needle into the slot, and when the sample tray is located in the shaking position, the slot is located in the first plane.

[0009] In some embodiments, the fully automated chemiluminescence immunoassay blood gas analyzer further includes a three-dimensional sample loading module, which includes a second longitudinal displacement module, a second lateral displacement module, a sampling needle lifting module, and a sampling needle module. The second longitudinal displacement module is drivenly connected to the second lateral displacement module, the second lateral displacement module is drivenly connected to the sampling needle lifting module, and the sampling needle lifting module is drivenly connected to the sampling needle module. The sample tray also has a sampling position, and the second longitudinal displacement module, the second lateral displacement module, and the sampling needle lifting module can drive the sampling needle module to draw whole blood from the blood collection needle located at the sampling position.

[0010] In some embodiments, the three-dimensional sample loading module further includes a transport lifting module and a transport gripper, the second lateral displacement module is also drivenly connected to the transport lifting module, and the transport lifting module is drivenly connected to the transport gripper; the fully automated luminescent immunoassay blood gas analyzer further includes a reagent card assembly, the reagent card assembly has several placement slots for placing reagent cups and magnetic bead cups, and the second longitudinal displacement module, the second lateral displacement module, and the transport lifting module can drive the transport gripper to grab the reagent cups and magnetic bead cups in the placement slots.

[0011] In some embodiments, the fully automated chemiluminescence immunoassay blood gas analyzer further includes a whole blood separation module, which includes a fixing module and a mixing module. The fixing module has a separation placement slot, and a magnet is provided at the bottom or one side of the separation placement slot. The mixing module includes a mixing seat and a mixing drive mechanism. The mixing seat has at least two mixing placement slots. The mixing seat is movably connected to the fixing module, and the mixing drive mechanism is driven to the mixing seat to drive the mixing seat to oscillate.

[0012] In some embodiments, the fully automated chemiluminescence immunoassay blood gas analyzer further includes an incubation photometric module, which includes an incubation tray, a thermostat module, and a photometric module. The incubation tray has multiple incubation holes arranged circumferentially. The incubation tray is disposed within the thermostat module and can rotate within the thermostat module. The thermostat module has an inlet / outlet and a photometric port. The photometric module is arranged facing the photometric port. The three-dimensional sample loading module can move the reagent cup located in the mixing placement tank to the incubation space directly opposite the inlet / outlet using a handling gripper.

[0013] In some embodiments, the sample loading module further includes a piston lifting module, wherein the lifting end of the piston lifting module corresponds to the sampling position and is used to push the piston of the blood collection needle upward.

[0014] In some embodiments, the shaking module further includes a blood collection needle recovery chamber, the upper surface of which is open, and the first longitudinal displacement module, the first lifting displacement module, the first rotating module, and the gripper can cooperate to put the blood collection needle into the blood collection needle recovery chamber.

[0015] In some embodiments, the whole blood separation module further includes a waste cup compartment with an open upper surface. The waste cup compartment is located directly below the fixed module, and the fixed module has a feeding port that communicates with the waste cup compartment for the magnetic bead cup to enter the waste cup compartment.

[0016] In some embodiments, the mixing drive mechanism includes a mixing motor, a rotating shaft, and an eccentric wheel. The mixing motor is connected to the eccentric wheel via the rotating shaft, and the eccentric wheel is driven to the mixing seat to drive the mixing seat to oscillate.

[0017] Compared with existing technologies, the fully automated chemiluminescence immunoassay blood gas analyzer provided by this invention integrates the functions of chemiluminescence and immunoassay blood gas analyzers. It utilizes the shaking module of the chemiluminescence immunoassay analyzer to assist the blood gas module in drawing blood samples. It can quantitatively detect the content of various proteins, antigens and other items in human serum, plasma and whole blood in vitro, and can also detect indicators such as oxygen, carbon dioxide, acid-base balance and electrolyte levels in blood in vitro. Only one blood sample is needed to complete both types of tests, reducing the burden on patients, reducing the consumption of consumables and simplifying the testing operation. Attached Figure Description

[0018] Figure 1 This is a schematic diagram of the structure of the fully automated chemiluminescence immunoassay blood gas analyzer provided in an embodiment of the present invention; Figure 2 yes Figure 1 A schematic diagram of the structure of the sample loading module; Figure 3 yes Figure 1 A schematic diagram of the structure of the mixing module; Figure 4 yes Figure 1 Schematic diagram of the structure of the blood and qi module; Figure 5 yes Figure 1 A schematic diagram of the three-dimensional sampling module; Figure 6 yes Figure 1 A schematic diagram of the structure of the Chinese medicine reagent card assembly; Figure 7 yes Figure 1 Schematic diagram of the whole blood separation module; Figure 8 yes Figure 1 A schematic diagram of the structure of the incubation photometry module. Detailed Implementation

[0019] To make the objectives, technical solutions, and advantages of this invention clearer, the invention will be further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative and not intended to limit the invention.

[0020] To address the technical challenge of requiring two separate devices for chemiluminescence immunoassay and blood gas analysis, this invention provides a fully automated chemiluminescence immunoassay blood gas analyzer that integrates the functions of both analyzers, allowing for the completion of both types of tests with just one blood sample.

[0021] Please see Figure 1 , Figure 1 This is a schematic diagram of the structure of the fully automated chemiluminescence immunoassay blood gas analyzer provided in an embodiment of the present invention; the fully automated chemiluminescence immunoassay blood gas analyzer includes: a sample loading module 1, a mixing module 2, and a blood gas module 3. It should be noted that, for ease of showing the internal structure of the analyzer, Figure 1 The outer casing and other structures of the analyzer are omitted. The fully automated luminescent immunoassay blood gas analyzer still includes an outer casing, and the casing is equipped with control buttons, a display screen, indicator lights, an inlet, and other structural components.

[0022] Please see Figure 1 and Figure 2 , Figure 2 yes Figure 1A schematic diagram of the sample loading module is shown. The sample loading module 1 includes a sample tray 11, which has a locking slot for receiving a blood collection needle 900. In this embodiment, the blood collection needle 900 is an arterial blood collection needle, and its structure is similar to a syringe. After collecting arterial blood, the needle tip is removed, and a sealing cap 910 is placed on the syringe opening. Then, it is manually inserted into the analyzer, and the sealing cap 910 is locked into the locking slot, thus completing the insertion of the blood collection needle. In this embodiment, the blood collection needle 900 is described using an arterial blood collection needle as an example. In other embodiments, the analyzer can also accept venous blood collection tubes and ampoules for sampling and luminescence analysis and quality control.

[0023] Please see Figure 1 and Figure 3 , Figure 3 yes Figure 1 A schematic diagram of the shaking module 2. The shaking module 2 includes a first longitudinal displacement module 21, a first lifting displacement module 22, a first rotation module 23, and a gripper 24. The longitudinal direction is... Figure 3 In the X-axis direction, the first longitudinal displacement module 21 is driven by the first lifting displacement module 22, thereby driving the first lifting displacement module 22 to move longitudinally. The first lifting displacement module 22 is driven by the first rotation module 23, thereby driving the first rotation module 23 to perform lifting motion, i.e., movement along the Z-axis. The first rotation module 23 is driven by the gripper 24, thereby driving the gripper 24 to rotate. The gripper 24 is electrically controlled and can perform gripping and releasing actions, used to grip the blood collection needle 900 in the slot.

[0024] Both the first longitudinal displacement module 21 and the first lifting displacement module 22 are linear displacement mechanisms. They can achieve linear displacement using common equipment such as ball screw mechanisms, cylinder mechanisms, and pulley mechanisms, and provide linear guidance using guide rails and guide rods. Linear displacement mechanisms are common in the mechanical field and are well-known to those skilled in the art; therefore, their specific structures will not be described in detail. The first longitudinal displacement module 21 and the first lifting displacement module 22 can work together to move the blood collection needle 900 within a first plane. The first plane is... Figure 3 The XY plane is shown. The first rotating module 23 includes a suitable type of motor and may also include a suitable reduction mechanism. The motor can be directly connected to the gripper 24 or connected to the gripper 24 through the reduction mechanism. The motor rotates alternately in two directions, thereby shaking the blood collection needle 900 at an appropriate rate via the gripper 24.

[0025] Please see Figure 3 and Figure 4 , Figure 4 yes Figure 1A schematic diagram of the blood gas module 3. The blood gas module 3 has an extendable blood gas sampling needle 31, which is located within a first plane and remains within this plane during movement. A first rotation module 23 rotates the blood collection needle 900 toward the blood gas sampling needle 31. A first longitudinal displacement module 21 and a first lifting displacement module 22 move the blood collection needle 900 toward the blood gas sampling needle 31. This allows the blood gas sampling needle 31 to pierce the sealing cap 910 and extend into the blood collection needle 900 to extract whole blood for blood gas analysis.

[0026] In this invention, the blood gas module 3 adopts an existing mature functional module, including a reagent package assembly, electrode card, hemolysis and optical components, and related electrical components. It can automatically absorb samples from the arterial blood collection needle delivered by the sample delivery assembly and detect indicators such as oxygen, carbon dioxide, acid-base balance, and electrolyte levels in the blood. A drive mechanism is set on the basis of the existing mature functional module to extend the blood gas sampling needle 31. This drive mechanism can be a linear drive mechanism such as a ball screw or electric push rod, or a rotary drive mechanism such as a motor. This invention does not limit the specific structure of the drive mechanism, only the driving direction. As long as the blood gas sampling needle 31 is located within the first plane and remains within the first plane during movement, the first longitudinal displacement module 21 and the first lifting displacement module 22 can drive the blood collection needle 900 towards the blood gas sampling needle 31, extending the blood gas sampling needle 31 into the blood collection needle 900.

[0027] Compared with existing technologies, the fully automated chemiluminescence immunoassay blood gas analyzer provided by this invention integrates the functions of chemiluminescence and immunoassay blood gas analyzers. Utilizing the shaking module 2 of the chemiluminescence immunoassay analyzer to assist the blood gas module 3 in drawing blood samples, it can quantitatively detect the content of various proteins, antigens, and other items in human serum, plasma, and whole blood in vitro. It can also detect indicators such as oxygen, carbon dioxide, acid-base balance, and electrolyte levels in the blood in vitro. Only one blood sample is needed to complete both types of tests, reducing the burden on patients, decreasing the consumption of consumables, and simplifying the testing operation.

[0028] Please see again Figure 2 In some embodiments, the sample loading module 1 further includes a rotary module 12, which is connected to the sample tray 11 to drive the sample tray 11 to rotate around its own axis. The rotary module 12 includes a motor of a suitable type and may also include a reduction mechanism with an appropriate transmission ratio. The motor can be directly connected to the sample tray 11 or connected to the sample tray 11 through the reduction mechanism to drive the sample tray 11 to rotate at an appropriate speed. The sample tray 11 has a sample placement position and a shaking position. When the sample tray 11 is in the sample placement position, it is used to place the blood collection needle 900 into the slot. When the sample tray 11 rotates to the shaking position, the slot is located in a first plane. The shaking module 2 can grasp the blood collection needle 900 and pull it out from the slot.

[0029] In a preferred embodiment, the sample tray 11 has multiple slots along its circumference, capable of holding multiple blood collection needles. That is, when one slot is located at the sample placement position, another slot is located at the mixing position. Different blood collection needles 900 are placed on the sample tray 11 for sequential testing, which improves processing efficiency. Furthermore, a barcode scanner 13 is preferably provided at the sample placement position to scan the code on the blood collection needle 900 to obtain information about the blood sample.

[0030] Please see again Figure 1 and Figure 3 In some embodiments, the shaking module 2 further includes a blood collection needle recovery chamber 25, with an open upper surface. The first longitudinal displacement module 21, the first lifting displacement module 22, the first rotating module 23, and the gripper 24 can cooperate to put the blood collection needle 900 after blood collection into the blood collection needle recovery chamber 25.

[0031] Please see Figure 1 and Figure 5 , Figure 5 yes Figure 1 A schematic diagram of the three-dimensional sample loading module. In some embodiments, the fully automated chemiluminescence immunoassay blood gas analyzer further includes a three-dimensional sample loading module 4. The three-dimensional sample loading module 4 includes a second longitudinal displacement module 41, a second transverse displacement module 42, a sampling needle lifting module 43, and a sampling needle module 44. The transverse direction is defined as being in the same horizontal plane as the longitudinal direction and perpendicular to it.

[0032] The second longitudinal displacement module 41 is driven by the second lateral displacement module 42 to drive the second lateral displacement module 42 to move longitudinally. The second lateral displacement module 42 is driven by the sampling needle lifting module 43 to drive the sampling needle lifting module 43 to move laterally. The sampling needle lifting module 43 is driven by the sampling needle module 44 to drive the sampling needle module 44 to move up and down. The sampling needle module 44 includes a negative pressure generating device and a sampling needle. The negative pressure generating device is connected to the sampling needle to generate negative pressure, enabling the sampling needle to aspirate whole blood from the blood collection needle 900.

[0033] Correspondingly, the sample tray 11 also has a sampling position. When rotated to the blood collection position, the second longitudinal displacement module 41, the second lateral displacement module 2 and the sampling needle lifting module 43 can drive the sampling needle module 44 to pierce the sealing cap 910 and extend into the blood collection needle 900 to draw whole blood.

[0034] The three-dimensional sample loading module 4 also has a cleaning module, which is connected to the sampling needle module 44 and is used to clean the sampling needles of the sampling needle module 44. The cleaning module is a standard structure for chemiluminescence immunoassay analyzers, and this solution can directly use existing mature cleaning modules.

[0035] Please see again Figure 2 Based on the above embodiments, the sample loading module 1 further includes a piston lifting module 14. The lifting end of the piston lifting module 14 corresponds to the sampling position and is used to push the piston of the blood collection needle 900 upward. This avoids negative pressure generated inside the blood collection needle 900 during aspiration, which could lead to aspiration difficulties. It is easy to understand that, to avoid collision between the piston and the sampling needle of the sampling needle module 44, the tip of the sampling needle is located in the upper part of the blood collection needle 900, just below the total blood surface, so that whole blood can be aspirated. Furthermore, at the end of the stroke of the piston lifting module 14, the piston will not contact the sampling needle. The rate at which the piston lifting module 14 pushes the piston must be adapted to the aspiration rate of the blood collection needle 900, so that the total blood surface is always kept above the needle tip, ensuring that the sampling needle does not draw in air.

[0036] Please see Figure 5 and Figure 6 , Figure 6 yes Figure 1 A schematic diagram of the structure of the Chinese medicine reagent card assembly.

[0037] In some embodiments, the three-dimensional sample loading module 4 further includes a transport lifting module 45 and a transport gripper 46. The second lateral displacement module 42 is also connected to the transport lifting module 45 by transmission, driving the transport lifting module 45 to move laterally. The transport lifting module 45 is connected to the transport gripper 46 by transmission, driving the transport gripper 46 to move up and down.

[0038] As is easily understood, the second longitudinal displacement module 41, the second lateral displacement module 42, the sampling needle lifting module 43, and the handling lifting module 45 are all linear displacement mechanisms. They can achieve linear displacement using common equipment such as ball screw mechanisms, cylinder mechanisms, and pulley mechanisms, and achieve linear guidance using guide rails and guide rods. Linear displacement mechanisms are common in the mechanical field and are well-known to those skilled in the art; therefore, their specific structures will not be described in detail.

[0039] The fully automated luminescent immunoassay blood gas analyzer also includes a reagent card assembly 5, which has several placement slots 51 for placing reagent cups and magnetic bead cups. The second longitudinal displacement module 41, the second transverse displacement module 42, and the transport lifting module 45 can drive the transport gripper 46 to grab the reagent cups and magnetic bead cups in the placement slots.

[0040] Please see Figure 1 and Figure 7 , Figure 7 yes Figure 1 A schematic diagram of the whole blood separation module.

[0041] In some embodiments, the fully automated chemiluminescence immunoassay blood gas analyzer further includes a whole blood separation module 6. The whole blood separation module 6 includes a fixing module 61 and a mixing module 62. The fixing module 61 has a separation placement slot 611, and a magnet is provided at the bottom or one side of the separation placement slot 611. The mixing module 62 includes a mixing seat 621 and a mixing drive mechanism 622. The mixing seat 621 has at least two mixing placement slots 6211. The mixing seat 621 is movably connected to the fixing module 61, and the mixing drive mechanism 622 is driven to the mixing seat 621 to drive the mixing seat 621 to oscillate. The second longitudinal displacement module 41, the second transverse displacement module 42, and the transport lifting module 45 can drive the transport gripper 46 to grab the reagent cup and magnetic bead cup in the placement slot of the reagent card assembly 5, and place them into the separation placement slot 611 or the mixing placement slot 6211 respectively for whole blood separation processing.

[0042] In some embodiments, the mixing drive mechanism 622 includes a mixing motor, a rotating shaft, and an eccentric wheel. The mixing motor is connected to the eccentric wheel via the rotating shaft, and the eccentric wheel is driven to the mixing seat 621 to drive the mixing seat to oscillate. The mixing seat 621 is connected to the fixed module 61 by a spring and achieves high-frequency oscillation under the push of the eccentric wheel.

[0043] Based on the above embodiments, the whole blood separation module 6 also includes a waste cup compartment 63. The upper surface of the waste cup compartment 63 is open and the waste cup compartment 63 is located directly below the fixed module 61. The fixed module 61 forms a feeding port that communicates with the waste cup compartment. The second longitudinal displacement module 41, the second transverse displacement module 42 and the transport lifting module 45 can drive the transport gripper 46 to grab the magnetic bead cup and put the magnetic bead cup into the waste cup compartment 61 through the feeding port.

[0044] Please see Figure 1 and Figure 8 , Figure 8 yes Figure 1 A schematic diagram of the incubation photometric module is shown. In some embodiments, the fully automated chemiluminescence immunoassay blood gas analyzer further includes an incubation photometric module 7, which includes an incubation tray, a photometric module 71, and a thermostatic module 72. The incubation tray has multiple circumferentially arranged incubation holes. The incubation tray is disposed within the thermostatic module 72 and can rotate within the thermostatic module 72, for example, a motor can be provided to drive the rotation of the incubation tray. The thermostatic module 72 is used to provide a stable incubation environment and has an inlet / outlet 721 and a photometric port 722. The photometric module 71 is arranged facing the photometric port 722.

[0045] The three-dimensional sample addition module 4 can move the reagent cup located in the mixing placement tank 6211 to the incubation space directly opposite the inlet / outlet 721 via the handling gripper 46. The incubation tray rotates the reagent cup into the constant temperature module 72 for incubation. After incubation, it is rotated to the photometric port 722, where the photometric module 71 performs photometric measurements. After photometric measurements are completed, it is rotated back to the inlet / outlet 721, and the three-dimensional sample addition module 4 can pick up the photometrically measured reagent cup via the handling gripper 46 and discard it into the waste cup bin 63 through the feeding port.

[0046] It should be noted that the movement stroke of the three-dimensional sample loading module 4 covers all the modules described above, so that the three-dimensional sample loading module 4 can complete the above-mentioned actions.

[0047] To better understand this invention, the following is combined with... Figures 1 to 8 The technical solution of the present invention will be described in detail below: After collecting arterial blood using the lancet 900, remove the needle and attach a sealing cap 910 to the syringe nozzle. Then, manually insert the syringe into the analyzer, locking the sealing cap 910 into the slot at the sample placement position. The barcode scanner 13 scans and records the data. The rotary module 12 then rotates the sample tray 11 from the sample placement position to the mixing position. The mixing module 2 drives the gripper 24 to clamp the lancet 900 and remove it from the slot. The first rotation module 23 drives the shaking of the lancet 900 to mix the whole blood within. The mixing module 2 then drives the gripper 24 to return the lancet 900 to its original slot. The rotary module 12 then rotates the sample tray 11 from the mixing position to the sampling position. The three-dimensional sampling module 4 drives the sampling needle module 44 to move, and the sampling needle of the sampling needle module 44 pierces the sealing cap 910 and extends into the blood collection needle 900 to draw a certain amount of whole blood. At the same time as the drawing, the piston lifting module 14 pushes the piston of the blood collection needle 900 upward to assist in the blood drawing. After the sampling needle module 44 draws the required amount of whole blood, it is pulled out of the blood collection needle 900, at which point some whole blood remains in the blood collection needle 900.

[0048] Then, on one hand, the three-dimensional sample addition module 4 drives the transport gripper 46 to pick up the reagent cup and magnetic bead cup from the reagent card assembly 5 respectively, and place them sequentially into the two mixing placement slots 6211. Alternatively, the reagent cup and magnetic bead cup can be transported and placed first, while the sampling needle module 44 draws whole blood. Then, the sampling needle module 44 adds the drawn whole blood into the magnetic bead cup, and the mixing drive mechanism 622 drives the mixing seat 621 to shake and oscillate, so that the red blood cells in the whole blood are adsorbed onto the surface of the magnetic beads in the magnetic bead cup. Then, the three-dimensional sample addition module 4 drives the transport gripper 46 to transport the magnetic bead cup from the mixing placement slot 6211 to the separation placement slot 611. A magnet is provided on one side wall or bottom of the separation placement slot 611 to hold the magnetic beads. Then, the three-dimensional sample addition module 4 drives the sampling needle module 44 to draw plasma from the magnetic bead cup (with red blood cells removed) and add the plasma into the reagent cup. Then, the mixing drive mechanism 622 drives the mixing seat 621 to shake and vibrate again, so that the plasma and reagent in the reagent cup are mixed evenly. Then, the three-dimensional sample addition module 4 drives the transport gripper 46 to transport the reagent cup to the incubation and photometric module 7 for incubation and photometric measurement, and then throws the magnetic bead cup and the photometric reagent cup into the waste cup compartment 63.

[0049] On the other hand, the rotary module 12 drives the sample tray 11 to rotate from the sampling position to the mixing position. The mixing module 2 drives the gripper 24 to grip the blood collection needle 900 again. The blood gas sampling needle 31 extended from the blood gas module 3 is moved towards the blood gas sampling needle 31 by the mixing module 2, which holds the blood collection needle 900, so that the blood gas sampling needle 31 is inserted into the blood collection needle 900, and the remaining whole blood in the blood collection needle 900 is extracted for blood gas detection.

[0050] It should be noted that after each extraction, the blood gas sampling needle 31 and the sampling needle module 44 will be cleaned by the cleaning module, and the wastewater after washing will be directed into the wastewater tank.

[0051] Through the above process, the fully automated chemiluminescence immunoassay blood gas analyzer provided by this invention can quantitatively detect the content of various proteins, antigens and other items in human serum, plasma and whole blood in vitro, and can also detect indicators such as oxygen, carbon dioxide, acid-base balance and electrolyte levels in blood in vitro. Only one blood sample is needed to complete both chemiluminescence analysis and blood gas analysis, which reduces the burden on patients, reduces the consumption of consumables and simplifies the testing operation.

[0052] The specific embodiments of the present invention described above do not constitute a limitation on the scope of protection of the present invention. Any other corresponding changes and modifications made in accordance with the technical concept of the present invention should be included within the scope of protection of the claims of the present invention.

Claims

1. A fully automated chemiluminescence immunoassay blood gas analyzer, characterized in that, include: The sample loading module includes a sample tray with a slot for holding a blood collection needle. The shaking module includes a first longitudinal displacement module, a first lifting displacement module, a first rotating module, and a gripper. The first longitudinal displacement module is driven to the first lifting displacement module, the first lifting displacement module is driven to the first rotating module, and the first rotating module is driven to the gripper. The gripper can grasp the blood collection needle in the slot. The first longitudinal displacement module and the first lifting displacement module can drive the blood collection needle to move in a first plane. The first rotating module can shake the blood collection needle via the gripper. The blood gas module has an extendable blood gas sampling needle located in the first plane; the first rotation module can rotate the blood sampling needle toward the blood gas sampling needle, and the first longitudinal displacement module and the first lifting displacement module drive the blood sampling needle to move toward the blood gas sampling needle.

2. The fully automated chemiluminescence immunoassay blood gas analyzer according to claim 1, characterized in that, The sample loading module further includes a rotary module, which is connected to the sample tray to drive the sample tray to rotate; the sample tray has a sample placement position and a shaking position. When the sample tray is located in the sample placement position, it is used to place a blood collection needle into the slot. When the sample tray is located in the shaking position, the slot is located in the first plane.

3. The fully automated chemiluminescence immunoassay blood gas analyzer according to claim 2, characterized in that, The fully automated chemiluminescence immunoassay blood gas analyzer also includes a three-dimensional sample loading module, which comprises a second longitudinal displacement module, a second lateral displacement module, a sampling needle lifting module, and a sampling needle module. The second longitudinal displacement module is drivenly connected to the second lateral displacement module, the second lateral displacement module is drivenly connected to the sampling needle lifting module, and the sampling needle lifting module is drivenly connected to the sampling needle module. The sample tray also has a sampling position, and the second longitudinal displacement module, the second lateral displacement module, and the sampling needle lifting module can drive the sampling needle module to draw whole blood from the blood collection needle located at the sampling position.

4. The fully automated chemiluminescence immunoassay blood gas analyzer according to claim 3, characterized in that, The three-dimensional sample addition module also includes a transport lifting module and a transport gripper. The second lateral displacement module is also connected to the transport lifting module in a transmission manner, and the transport lifting module is connected to the transport gripper in a transmission manner. The fully automatic luminescent immunoassay blood gas analyzer also includes a reagent card assembly. The reagent card assembly has several placement slots for placing reagent cups and magnetic bead cups. The second longitudinal displacement module, the second lateral displacement module, and the transport lifting module can drive the transport gripper to grab the reagent cups and magnetic bead cups in the placement slots.

5. The fully automated chemiluminescence immunoassay blood gas analyzer according to claim 4, characterized in that, The fully automated chemiluminescence immunoassay blood gas analyzer also includes a whole blood separation module, which comprises a fixing module and a mixing module. The fixing module has a separation placement slot, and a magnet is provided at the bottom or one side of the separation placement slot. The mixing module includes a mixing seat and a mixing drive mechanism. The mixing seat has at least two mixing placement slots. The mixing seat is movably connected to the fixing module, and the mixing drive mechanism is driven to the mixing seat to drive the mixing seat to oscillate.

6. The fully automated chemiluminescence immunoassay blood gas analyzer according to claim 5, characterized in that, The fully automated chemiluminescence immunoassay blood gas analyzer also includes an incubation and photometric module, which comprises an incubation tray, a thermostat, and a photometric module. The incubation tray has multiple circumferentially arranged incubation wells. The incubation tray is located within the thermostat and can rotate within the thermostat. The thermostat has an inlet / outlet and a photometric port, and the photometric module is positioned facing the photometric port. The three-dimensional sample loading module can move the reagent cup located in the mixing tank to the incubation space directly opposite the inlet / outlet using a handling gripper.

7. The fully automated chemiluminescence immunoassay blood gas analyzer according to claim 3, characterized in that, The sample loading module also includes a piston lifting module, the lifting end of which corresponds to the sampling position and is used to push the piston of the blood collection needle upward.

8. The fully automated chemiluminescence immunoassay blood gas analyzer according to claim 1, characterized in that, The shaking module also includes a blood collection needle recovery chamber, the upper surface of which is open. The first longitudinal displacement module, the first lifting displacement module, the first rotating module, and the gripper can cooperate to put the blood collection needle into the blood collection needle recovery chamber.

9. The fully automated chemiluminescence immunoassay blood gas analyzer according to claim 5, characterized in that, The whole blood separation module also includes a waste cup compartment with an open upper surface. The waste cup compartment is located directly below the fixed module, and the fixed module has a feeding port that connects to the waste cup compartment for the magnetic bead cup to enter the waste cup compartment.

10. The fully automated chemiluminescence immunoassay blood gas analyzer according to claim 5, characterized in that, The mixing drive mechanism includes a mixing motor, a rotating shaft, and an eccentric wheel. The mixing motor is connected to the eccentric wheel via the rotating shaft, and the eccentric wheel is connected to the mixing seat to drive the mixing seat to oscillate.

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