An enema formulation for the treatment of ulcerative colitis
By combining thalidomide with carbomer gel to prepare an enema formulation, the problems of large side effects and poor therapeutic effects of oral thalidomide formulations are solved, achieving the effects of high local drug concentration, few side effects, long retention time, and good therapeutic effect.
CN121550225BActive Publication Date: 2026-07-24PEKING UNION MEDICAL COLLEGE HOSPITAL
View PDF 0 Cites 0 Cited by
Patent Information
- Application Number
- CN202510293673.9
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2025-03-13
- Publication Date
- 2026-07-24
- Estimated Expiration
- 2045-03-13
Smart Images
Figure CN121550225B_ABST
Abstract
The application discloses an enema preparation for treating ulcerative colitis, which contains 0.01-2g of thalidomide, 30-150ml of dimethyl sulfoxide, 1-5g of carbomer per liter of the enema preparation, and further comprises a pH regulator for adjusting the pH to 5.5-9.0 and deionized water. The enema preparation has simple components and preparation method and high biocompatibility, can improve the local concentration and residence time of thalidomide in the intestinal tract, reduce the side effects of thalidomide and improve the treatment effect of thalidomide on ulcerative colitis, especially left-sided ulcerative colitis.
Need to check novelty before this filing date? Find Prior Art