A daoyi composition for treating eye diseases and a preparation method and application thereof

Abstract

The application discloses a Dai medicine composition for treating eye diseases and a preparation and application thereof. The Dai medicine composition for treating eye diseases is composed of chrysanthemum, carthamus tinctorius seed, periostracum cicadae, asarum, imperata cylindrica, Daemonorops draco, honey locust, and licorice. The Dai medicine composition for treating eye diseases is added with pharmaceutically acceptable adjuvants to be prepared into a preparation. The Dai medicine composition for treating eye diseases and the preparation thereof can be used for preparing a medicine for treating eye diseases.

Description

Technical Field

[0001] This invention belongs to the field of pharmaceuticals, specifically relating to a Dai medicine composition for treating eye diseases, its preparation method, and its application. Background Technology

[0002] With the development of technology, more and more people are accustomed to using electronic devices for work, social interaction, and learning. However, prolonged focus on electronic screens has led to approximately 700 million people developing eye diseases such as myopia, astigmatism, floaters, cataracts, and macular degeneration.

[0003] For the aforementioned eye diseases, the primary treatment currently employs Western medicine, using oral medications, eye drops, or surgery to alleviate and prevent symptoms. Regarding myopia, the main Western medical solution is wearing glasses to slow the progression of nearsightedness. Simultaneously, Traditional Chinese Medicine (TCM) uses acupuncture, massage, and other techniques to improve ocular microcirculation and alleviate eye conditions. While both Western and TCM treatments have achieved some success in alleviating eye diseases, their efficacy in curing myopia, astigmatism, cataracts, relieving eye fatigue, and preventing dry eyes is limited. Furthermore, the safety of eye surgeries and eye drops is unknown and may cause side effects.

[0004] The currently published technologies, such as CN106853207B which discloses a traditional Chinese medicine composition for treating myopia in adolescents and its preparation method, are oral medications applicable only to adolescents, with limited selection criteria for adolescents. Their efficacy in treating pathological eye problems is unknown, thus limiting product functionality and target audience. CN1528434A discloses a traditional Chinese medicine composition for treating myopia and its preparation method, but this formula uses expensive traditional Chinese medicines such as musk, bear bile, and bezoar, resulting in high product costs and hindering market promotion. CN114748585B discloses a traditional Chinese medicine formula for alleviating the progression of myopia in children and adolescents and its preparation method, but this only controls the progression of myopia and has no significant improvement effect on myopia. Summary of the Invention

[0005] In view of the shortcomings of the existing technology, the purpose of this invention is to provide a Dai medicine composition for treating eye diseases, its preparation method and application. The medicine composition can effectively solve various eye diseases such as dry eyes, eye fatigue, cataracts, floaters, tearing, redness and swelling, and effectively improve myopia.

[0006] The objective of this invention is achieved through the following technical solution:

[0007] A Dai medicine composition for treating eye diseases, comprising, by weight, the following components: 90-100 parts chrysanthemum, 90-100 parts celosia seed, 90-100 parts cicada slough, 50-80 parts asarum, 50-80 parts imperata root, 50-80 parts scutellaria barbata, 25-45 parts honey, 25-45 parts wild licorice, and 5-10 parts honey.

[0008] Preferably, the Dai medicine composition for treating eye diseases comprises, by weight, the following components: 90-97 parts chrysanthemum, 90-97 parts celosia seed, 90-97 parts cicada slough, 50-70 parts asarum, 50-70 parts imperata root, 50-70 parts scutellaria barbata, 25-40 parts honey, 25-40 parts wild licorice, and 5-8 parts honey.

[0009] More preferably, the Dai medicine composition for treating eye diseases comprises, by weight, the following components: 90-95 parts of chrysanthemum, 90-95 parts of celosia seed, 90-95 parts of cicada slough, 50-60 parts of asarum, 50-60 parts of imperata root, 50-60 parts of vine, 25-35 parts of honey, 25-35 parts of wild licorice, and 5-6 parts of honey.

[0010] Dai medicine theory holds that the occurrence of diseases is related to the imbalance of the four elements (wind, fire, water, and earth) in a person. Books such as *Luoge Yatan* (Tannai Luo) and *Weisutimaga* describe the eye as: "resembling a blue lotus flower, with black eyelashes and a round sphere with black and white markings. Within the white circle, in front of the center of the black pupil, is a membrane (wick) permeated with oil." It is the place where the human body and all things are reflected. It is supported by the binding of earth (soil), the maturation and nourishment of water (blood), the warmth of fire, and the promotion (aid) of wind (qi). It is also supported by natural phenomena such as seasons and temperature changes, as well as the mind (spirit) and food (nutrients), producing the function of seeing and sensing objects (photosensory perception), thus distinguishing various objects, shapes, and colors. Therefore, when the four elements (earth, water, fire, and wind) are imbalanced, and there is an excess of wind (qi) due to insufficient parental innate endowment (in which case the disease often manifests in the liver and gallbladder), or insufficient earth (referring to the body as a whole), it can cause blurred vision, weakened eyesight, yellowing of the eyes, and color blindness. When a patient habitually consumes spicy and pungent foods, the accumulation of heat in the stomach and intestines can lead to "excessive fire," resulting in sudden onset of conjunctivitis, dizziness, and blurred vision. When wind-evil invades the internal organs, it can cause "dizziness and vertigo."

[0011] According to Dai medicine theory, the pharmaceutical composition of this invention contains:

[0012] Chrysanthemums are associated with wind and fire elements. For eye discomfort caused by excessive wind, they can effectively dispel wind and restore balance to the eye area. For symptoms such as liver fire rising, red and swollen eyes caused by excessive fire, they can clear liver fire and return the eye area to a normal state, thereby reducing eye inflammation and discomfort and keeping the eyes refreshed.

[0013] Celosia seed, when used in relation to water and wind, is beneficial for addressing issues like eye swelling and blurred vision caused by imbalances in the water metabolism system. It can regulate the water metabolism system and promote normal fluid metabolism. Simultaneously, it can dispel wind-evil accumulation in the eyes caused by wind-evil malfunctions, improving blood circulation in the eyes. It also has excellent anti-inflammatory and analgesic effects on eye inflammation caused by excessive liver fire, such as red, swollen, and painful eyes, and pterygium, helping to eliminate inflammatory reactions and alleviate pain and discomfort.

[0014] Cicada molts, whether in water or in wind, can help regulate fluid metabolism, ensuring proper fluid distribution in the eyes and preventing imbalances that could impair eye function. As for wind, cicada molts effectively dispel wind-evil, expelling accumulated wind-cold and wind-heat from the eyes, promoting blood circulation, and alleviating eye discomfort caused by wind-evil, such as redness and itching.

[0015] Asarum, when used in traditional Chinese medicine, is associated with wind and water. In wind-related cases, it dispels wind and cold, effectively addressing eye discomfort caused by wind-evil invasion, such as dizziness and vertigo. In water-related cases, it helps warm and regulate fluid metabolism, maintaining the fluid balance in the eyes, providing a good water environment for eye tissues, and ensuring normal eye function.

[0016] Imperata cylindrica root, when added to a water tower, can regulate fluid balance, promote the excretion of excess water from the body, maintain the fluid balance of the eyes, and effectively improve blood circulation in the eyes, promoting smooth blood flow, reducing platelet aggregation, preventing blood stasis and thrombosis that could lead to local hypoxia and insufficient nutrient supply, providing sufficient nutrition to intraocular cells and nerves, nourishing damaged cells, including the cornea, lens, retina, and muscles, enhancing cell activity, and promoting cell metabolism.

[0017] Huangteng (Radix et Rhizoma Curcumae), used in both aquatic and wind-related applications, can clear heat and dampness, regulate fluid metabolism, and prevent eye problems caused by water retention. In wind-related applications, it can dispel wind-evil, and when combined with other medications, expel accumulated wind-cold and wind-heat from the eyes. It also has a good anti-inflammatory and analgesic effect on eye inflammation caused by excessive liver fire, eliminating inflammatory reactions and reducing pain.

[0018] *Artocarpus heterophyllus* Lam., a plant in the Moraceae family, is listed in the *Guangxi Medicinal Plant List* and *Chinese Tree Taxonomy*. The leaves are mostly longitudinally rolled inwards, flattening to an elliptical-obovate shape, grayish-green on the upper surface and grayish-yellow on the lower surface, with prominent veins. It has a faint odor and a bland taste. The leaves are harvested and dried in summer and autumn when the branches and leaves are lush. It possesses nourishing, moisturizing, and detoxifying properties. When added to fire pits or earthen pits, *Artocarpus heterophyllus* can moisturize dryness and regulate the body's dryness caused by excessive heat, thus balancing the fire. Simultaneously, it nourishes the body, providing nutrients to the eye tissues and helping to maintain normal eye function. It also has a nourishing and supplementing effect on problems such as eye nutrient deficiency caused by insufficient earth energy.

[0019] Wild licorice root, when used in water and wind-related applications, can dispel wind and heat, expel wind-evil from the eyes, and promote smooth blood and qi circulation in the eyes. It also regulates water metabolism through its diuretic properties, maintaining the fluid balance in the eyes and thus preserving their health.

[0020] Honey has the effect of "combining all medicines and detoxifying all poisons". In the drug composition described in this invention, it mainly moderates the properties of the medicines and harmonizes the various medicines, reduces the toxicity of the medicines (such as scutellaria baicalensis and asarum sieboldii), promotes the absorption of the medicines, protects the liver, reduces the mutual conflict and adverse reactions between the medicines, and fully exerts the therapeutic effect of the medicines.

[0021] Honey and wild licorice work together to clear blood vessels around the eyes, ensuring that nutrients and oxygen can be smoothly delivered to various tissues in the eye, improving the metabolism of tissues such as the retina and choroid, and enhancing their function.

[0022] The combination of chrysanthemum, asarum, cicada slough, and codonopsis can expel wind-cold and wind-heat accumulated in the eyes, dispel external pathogens, and maintain smooth blood circulation and a clean eye environment. Simultaneously, this combination also has a good anti-inflammatory and analgesic effect on eye inflammation caused by excessive liver fire, such as red, swollen, and painful eyes, and pterygium. It can eliminate inflammatory reactions in the eyes, reduce pain and discomfort caused by inflammation, and create favorable conditions for the repair of intraocular tissues.

[0023] The combination of chrysanthemum, asarum, and imperata root provides ample nutrition to intraocular cells and nerves, nourishing damaged cells, including those in the cornea, lens, retina, and muscles. It relieves ciliary muscle spasm, enhances cell activity, promotes cell metabolism, repairs damaged nerve fibers, restores nerve conduction function, improves the eye's accommodation function, and achieves the repair and regeneration of intraocular tissues, restoring clarity and vitality to the eyes. At the same time, it also enhances the elasticity and resilience of intraocular tissues, helping to maintain the normal shape and physiological function of the eyeball, and has a positive impact on improving myopia and astigmatism.

[0024] Overall, the formula first promotes blood circulation and removes blood stasis, clears blood vessels, then expels wind-cold and wind-heat, reduces inflammation and relieves pain, and nourishes cells and nerves, thus achieving the effect of repairing intraocular tissues.

[0025] Compared with the prior art, the present invention has the following beneficial effects:

[0026] 1. The Dai medicine composition described in this invention is made from pure plant extracts, is hormone-free and non-irritating. It is applied using traditional methods, and through the penetration of medicinal vapors, it regulates blood circulation in the eyes, clears the meridians, and increases blood supply to the eyes. In addition, the ingredients in the medicine can help the eyes see clearly and allow the eyes to self-repair and improve. It can effectively solve various eye diseases such as dry eyes, eye fatigue, cataracts, floaters, tearing, redness and swelling.

[0027] 2. The Dai medicine composition of the present invention can relax the ciliary muscle, control ciliary muscle spasm, inhibit lens thickening, moisturize cells and nerves around the eyes, regulate blood circulation in the eyes, dredge meridians around the eyes, improve retinal function, improve vision, repair optic nerve, effectively improve myopia, and can also effectively treat eye diseases such as conjunctivitis, keratitis, and red eyes.

[0028] 3. The Dai medicine composition described in this invention is a topical medicine that acts directly on the affected area, fully exerting its medicinal effects to achieve the therapeutic effect on eye diseases. It is also safe to use, avoiding the discomfort and side effects that may be caused by oral medications and surgery.

[0029] 4. The Dai medicine composition described in this invention can not only treat eye diseases, but also nourish the heart and spleen, clear the liver and kidneys, moisten the lungs, clear heart fire, and clear heat and detoxify, thereby regulating the five internal organs and bringing the four elements of wind, fire, water, and wood into balance.

[0030] 5. The Dai medicine composition described in this invention is suitable for a wide range of people, from children and adolescents to the elderly, meeting the eye health needs of different groups and helping to improve the overall eye health level of society. Detailed Implementation

[0031] The present invention will be further described below with reference to the embodiments, but the present invention is not limited to the embodiments. Example 1

[0032] A Dai medicine composition for treating eye diseases, comprising the following components: 90g chrysanthemum, 90g celosia seed, 90g cicada slough, 50g asarum, 50g imperata root, 50g scutellaria barbata, 25g honey, 25g wild licorice, and 5g honey. Example 2

[0033] A Dai medicine composition for treating eye diseases, comprising the following components: chrysanthemum 95g, celosia seed 95g, cicada slough 95g, asarum 65g, imperata root 65g, scutellaria barbata 65g, honey 35g, wild licorice 35g, and honey 5g. Example 3

[0034] A Dai medicine composition for treating eye diseases, comprising the following components: 100g chrysanthemum, 100g celosia seed, 100g cicada slough, 80g asarum, 80g imperata root, 80g scutellaria barbata, 45g honey, 45g wild licorice, and 6g honey. Example 4

[0035] A Dai medicine composition for treating eye diseases, comprising the following components: 90g chrysanthemum, 93g celosia seed, 95g cicada slough, 70g asarum, 80g imperata root, 50g scutellaria barbata, 30g honey, 35g wild licorice, and 8g honey. Example 5

[0036] A Dai medicine composition for treating eye diseases, comprising the following components: chrysanthemum 93g, celosia seed 95g, cicada slough 97g, asarum 80g, imperata root 50g, scutellaria barbata 60g, honey 35g, wild licorice 40g, and honey 10g. Example 6

[0037] A Dai medicine composition for treating eye diseases, comprising the following components: chrysanthemum 95g, celosia seed 97g, cicada slough 100g, asarum 50g, imperata root 60g, scutellaria barbata 65g, honey 40g, wild licorice 45g, and honey 5g. Example 7

[0038] A Dai medicine composition for treating eye diseases, comprising the following components: chrysanthemum 97g, celosia seed 100g, cicada slough 90g, asarum 60g, imperata root 65g, scutellaria barbata 70g, honey 45g, wild licorice 25g, and honey 6g. Example 8

[0039] A Dai medicine composition for treating eye diseases, comprising the following components: 100g chrysanthemum, 90g celosia seed, 93g cicada slough, 65g asarum, 70g imperata root, 80g scutellaria barbata, 25g honey, 30g wild licorice, and 7g honey. Example 9

[0040] A formulation of a Dai medicine composition for treating eye diseases, wherein the medicinal materials are weighed according to any one of Examples 1 to 8, placed in a ventilated room, and the medicinal materials other than honey are crushed into coarse powder and mixed evenly. Then, honey is mixed with the mixed powder in equal amounts, and warm water at 40°C is added according to the weight ratio of mixture:water = 1:4. The mixture is stirred into a viscous consistency, spread evenly on an eye patch, and then applied to the eye area.

[0041] Application Example 1 – Observation of the Effects of the Dai Medicine Composition of the Present Invention

[0042] This application example observed 750 patients aged 6 to 78 years. Symptoms included: dry eyes, eye irritation, itchy eyes, photophobia, eye fatigue, swelling, myopia, astigmatism, floaters, macular degeneration, pterygium, keratitis, blepharitis, and cataracts. The vast majority of patients exhibited multiple symptoms simultaneously; for example, dry eyes, eye irritation, itchy eyes, and eye fatigue often occurred alongside other symptoms.

[0043] 1. Diagnostic methods

[0044] 1.1 Diagnostic methods in Dai medicine

[0045] 1.1.1 Visual Diagnosis

[0046] Observe the size and shape of the eyes, whether the eyelids are swollen, and whether the eyeballs are protruding or sunken; observe whether the eyes are bright and lively, and whether they are dull or lifeless; observe the color of the sclera, cornea, and pupil. Redness of the sclera is often due to wind-heat or liver fire, while yellowing of the sclera may be related to damp-heat in the liver and gallbladder. Cloudy cornea with pterygium is often due to heat toxin or phlegm-dampness obstruction. Changes in the color of the pupil, such as becoming lighter or grayer, may indicate liver and kidney deficiency or blood stasis.

[0047] 1.1.2 Medical Consultation

[0048] Ask the patient if they have symptoms such as eye pain, itching, dryness, blurred vision, or tearing; inquire if the patient also has systemic symptoms such as headache, dizziness, bitter taste in the mouth, dry throat, or weakness in the lower back and knees; and inquire about the patient's dietary preferences, work environment, and eye habits.

[0049] 1.1.3 Palpation

[0050] Touch the eyelids and the area around the eye sockets to feel for swelling, tenderness, or hardening; and judge the pulse's strength, weakness, coldness, or heat by feeling the cun-kou pulse.

[0051] 1.2 Western Medicine Diagnostic Methods

[0052] Dry eyes, itchy eyes, photophobia, eye fatigue, swelling, floaters, pterygium, and blepharitis can be diagnosed through consultation, observation, and palpation in Dai medicine; myopia, astigmatism, macular degeneration, keratitis, and cataracts require Western medical diagnostic methods to assist in diagnosis.

[0053] 2. Diagnostic criteria

[0054] 2.1 Diagnostic and Syndrome Differentiation Standards in Dai Medicine

[0055] (1) Dry eyes: Diagnosis is made through observation, inquiry and palpation. Dry eyes can be divided into four types. Excessive fire tower: symptoms include dry and burning eyes, conjunctival congestion, photophobia, bitter taste in the mouth, red tongue with yellow coating, and high temperature around the eyes. Clearing heat and detoxifying can relieve the symptoms. Deficiency of water tower: symptoms include dry and dull eyes, worse at night, dry mouth and throat, pale tongue with little saliva, and dry skin around the eyes. Nourishing yin and moisturizing dryness can relieve the symptoms. Disorder of wind tower: symptoms include dry eyes accompanied by dizziness, fluctuating symptoms (related to emotions), insomnia, and tension of muscles around the eyes. Regulating wind and calming the mind can relieve the symptoms. Disorder of earth tower: symptoms include dry eyes accompanied by indigestion, poor appetite, sallow complexion, and eyelid edema. Strengthening the spleen and promoting body fluid can relieve the symptoms.

[0056] (2) Eye discomfort: Diagnosis is made through observation, inquiry and palpation. Eye discomfort can be divided into four types. Excessive fire tower: manifested as burning pain in the eyes, conjunctival congestion, thick secretions, accompanied by bitter taste in the mouth, constipation, red tongue with yellow coating. Clearing heat and detoxifying can relieve the symptoms. Insufficient water tower: manifested as eye discomfort without congestion, little tears, worsening at night, accompanied by dry skin, pale tongue with little saliva. Nourishing yin and generating fluids can relieve the symptoms. Disturbed wind tower: manifested as itchy eyes, aversion to wind, fluctuating symptoms (such as worsening after exposure to wind), thin white tongue coating. Dispelling wind and unblocking the meridians can relieve the symptoms. Weak earth tower: manifested as eye discomfort accompanied by visual fatigue, poor appetite, sallow complexion, swollen tongue with teeth marks. Strengthening the spleen and nourishing blood can relieve the symptoms.

[0057] (3) Itchy eyes: Diagnosis is made through observation, inquiry and palpation. Itchy eyes can be divided into four syndromes. Excessive wind tower: Itchy eyes are characterized by sudden onset, which is aggravated by wind, accompanied by nasal itching, sneezing, thin and clear tears, mild conjunctival congestion, and thin white tongue coating. Expelling wind can relieve itching. Excessive fire tower: Itchy and burning eyes are characterized by thick yellow secretions, obvious conjunctival congestion, accompanied by bitter taste in the mouth, constipation, yellow urine, red tongue with yellow coating. Clearing heat and detoxifying can relieve itching. Insufficient water tower: Itchy and dry eyes are characterized by itching and dryness, which is aggravated after rubbing the eyes, peeling of the skin around the eyes, pale complexion, pale tongue with little saliva. Nourishing yin and blood can relieve itching. Imbalanced earth tower: Itchy and swollen eyelids with erosion, itching and pain, yellow and greasy tongue coating. Clearing heat and dampness can relieve itching.

[0058] (4) Photophobia: Diagnosis is made through observation, inquiry and palpation. Photophobia can be divided into four types. Excessive fire tower: photophobia is characterized by red eyes, burning sensation, thick yellow secretions, red tongue with yellow coating. Clearing heat and detoxifying can relieve it. Insufficient water tower: photophobia without congestion, worse at night, dry mouth and throat, red tongue with little coating. Nourishing yin and reducing fire can relieve it. Disturbed wind tower: photophobia is characterized by headache, dizziness, irritability, red tongue edges. Calming the liver and extinguishing wind can relieve it. Weak earth tower: photophobia is characterized by worsening after fatigue, sallow complexion, poor appetite, pale tongue. Strengthening the spleen and nourishing blood can relieve it.

[0059] (5) Eye fatigue: Diagnosis is made through observation, inquiry and palpation. Eye fatigue can be divided into three syndromes. Earth Tower deficiency is manifested as spleen dysfunction, swollen tongue with teeth marks, poor appetite, loose stools, milder in the morning and more severe in the evening. Strengthening the spleen and nourishing blood can relieve it. Water Tower deficiency is manifested as liver and kidney yin deficiency, red tongue with little coating, dry eyes, tinnitus and lower back pain, which are aggravated by staying up late. Nourishing yin and moistening dryness can relieve it. Wind Tower disturbance is manifested as liver yang hyperactivity, red tongue edges, irritability, headache and dizziness, which are aggravated by anger. Calming the liver and extinguishing wind can relieve it.

[0060] (6) Eye swelling: Diagnosis is made through observation, inquiry and palpation. Eye swelling can be divided into four types. Water tower imbalance: manifested as spleen failing to transport dampness, eyelid edema, pitting when pressed, worsening in the morning, large tongue with teeth marks, can be relieved by strengthening the spleen and promoting diuresis. Fire tower excess: manifested as heat toxin stagnation, red and swollen eyes, burning and tenderness, thick yellow secretions, red tongue with yellow coating, can be relieved by clearing heat and detoxifying. Wind tower disturbance: manifested as external evil attacking the surface, sudden itchy and swollen eyes, fear of wind and tearing, accompanied by nasal congestion and runny nose, thin white tongue coating, can be relieved by dispelling wind and removing dampness. Earth tower weakness: manifested as qi and blood stagnation, hard swelling of eyelids, lingering course of disease, dull complexion, dark purple tongue with greasy coating, can be relieved by resolving phlegm and dispersing nodules, promoting blood circulation and removing blood stasis.

[0061] (7) Floaters: Diagnosis is made through observation, inquiry and palpation. Floaters can be divided into four syndrome types. Water Tower Turbidity: manifested as dampness rising upwards, black shadows like cotton, worsening in the morning, feeling heavy in the head, and white and greasy tongue coating. Strengthening the spleen and draining dampness can relieve the symptoms. Wind Tower Disturbance: manifested as phlegm and dampness obstructing the collaterals, black shadows floating around, worsening with emotional fluctuations, and thick and greasy tongue coating. Calming the liver and extinguishing wind can relieve the symptoms. Water Tower Deficiency and Fire Tower Excess: manifested as black shadows accompanied by flashes, more obvious at night, dry mouth and throat, red tongue with little coating. Nourishing yin and reducing fire can relieve the symptoms. Earth Tower Weakness: manifested as qi and blood deficiency, thin black shadows, visual fatigue, sallow complexion, and pale tongue. Strengthening the spleen and replenishing qi can relieve the symptoms.

[0062] (8) Pterygium: Diagnosis is made through observation, inquiry and palpation. Pterygium can be divided into four types. Wind Tower Disturbance: It is manifested as external invasion of heat evil. The pterygium is thin and transparent at the beginning and aggravated by wind. There is a lot of clear and thin tears. The tongue is red with a thin yellow coating. It can be relieved by dispelling wind and clearing heat. Fire Tower Excess: It is manifested as red, swollen and raised pterygium with burning pain, a lot of thick yellow discharge, a red tongue with a dry yellow coating. It can be relieved by clearing heat and detoxifying. Earth Tower Disharmony: It is manifested as stiff, thick and dark-colored pterygium, heavy eyelids, a dark purple tongue with a greasy coating. It can be relieved by resolving phlegm and dispersing nodules, and promoting blood circulation and clearing away pterygium. Water Tower Deficiency: It is manifested as wind disturbing the upper body. The pterygium is pale red and sometimes hidden. It is dry and blurry. It is aggravated in the afternoon. The tongue is red with little moisture. It can be relieved by nourishing yin and extinguishing wind.

[0063] (9) Blepharitis: Diagnosis is made through observation, inquiry and palpation. Blepharitis can be divided into four syndromes. Wind tower disturbance: manifested as red eyelids, burning and itching, which worsens with wind, red tongue with thin yellow coating, which can be relieved by clearing heat and detoxifying. Earth tower imbalance: manifested as wet and oozing eyelids, eyelashes sticking together, abdominal distension, red tongue with yellow and greasy coating, which can be relieved by clearing heat and removing dampness, detoxifying and reducing swelling. Earth tower deficiency: manifested as edematous and dull eyelids, recurrent attacks, loss of appetite, pale and swollen tongue with teeth marks, which can be relieved by strengthening the spleen and replenishing qi, resolving dampness and harmonizing the stomach. Water tower deficiency: manifested as dry and cracked eyelids, scales, sallow complexion, pale tongue with little saliva, which can be relieved by nourishing blood and moisturizing dryness, dispelling wind and relieving itching.

[0064] 2.2 Western Medicine Diagnostic Criteria

[0065] (1) Myopia: Uncorrected visual acuity was measured using the national standard GB / T 11533-2011 Standard Logarithmic Visual Acuity Chart. The examinee was 5 meters away from the chart, with one eye covered, and began to identify the visual targets from the largest to the smallest line. The smallest line of visual targets that could be clearly seen was recorded. The visual acuity standards for children are relatively low. For example, a 3-year-old child should have a visual acuity of ≥4.7 (0.5), a 5-year-old child should have a visual acuity of ≥4.8 (0.6), and a child aged 7 and above should have a visual acuity close to the adult standard of ≥5.0 (1.0). If the distance visual acuity is lower than 5.0 (or 1.0), it may indicate a refractive error, such as myopia.

[0066] According to the "Guidelines for the Prevention and Treatment of Myopia (2024 Edition)," myopia is classified into three categories—low myopia, moderate myopia, and high myopia—based on the equivalent spherical power (SE) measured after cycloplegia (equivalent spherical power = spherical power + 1 / 2 cylindrical power):

[0067] Low myopia: Myopia degree between 50 and 300 degrees (-3.00D) <SE≤-0.50D);

[0068] Moderate myopia: Myopia between 300 and 600 degrees (-6.00D) <SE≤-3.00D);

[0069] High myopia: Myopia degree exceeding 600 degrees (SE≤-6.00D).

[0070] The degree of myopia is measured.

[0071] (2) Astigmatism: Uncorrected visual acuity was measured using the national standard GB / T 11533-2011 Standard Logarithmic Visual Acuity Chart. The examinee was 5 meters away from the chart, with one eye covered, and began to identify the visual targets from the largest to the smallest line. The smallest line of visual targets that could be clearly seen was recorded. The visual acuity standards for children are relatively low. For example, a 3-year-old child should have a visual acuity of ≥4.7 (0.5), a 5-year-old child should have a visual acuity of ≥4.8 (0.6), and a child aged 7 and above should have a visual acuity close to the adult standard of ≥5.0 (1.0). If the distance visual acuity is lower than 5.0 (or 1.0), it may indicate the presence of refractive errors, such as astigmatism.

[0072] The astigmatism power was measured using the cross-cylinder method (JCC), and the degree of astigmatism was classified into three categories according to the power.

[0073] Mild astigmatism: Astigmatism degree less than 0.5D (less than 50 degrees).

[0074] Moderate astigmatism: The degree of astigmatism is between 0.5D and 1.5D (between 50 degrees and 150 degrees).

[0075] High astigmatism: Astigmatism degree between 1.5D and 3.0D (between 150 degrees and 300 degrees).

[0076] (3) Macular degeneration: The Chinese Clinical Diagnosis and Treatment Guidelines for Age-Related Macular Degeneration (2023) state that macular degeneration can be detected by fundus photography, fluorescein fundus angiography (FFA), indocyanine green angiography (ICGA), optical coherence tomography (OCT), and optical coherence tomography angiography (OCTA).

[0077] Clinical manifestations: Non-AMD stage: No or only a few small drusen.

[0078] Early AMD: Multiple small drusen or mild RPE abnormalities.

[0079] Intermediate AMD: Extensive medium-sized drusen or at least one large drusen, or GA without involvement of the fovea of ​​the macula.

[0080] Advanced AMD: GA or neovascular AMD involving the fovea of ​​the macula, which may be accompanied by hemorrhage, exudation, PED, etc.

[0081] (4) Keratitis: Keratitis refers to inflammation of the corneal tissue, clinically manifested as pain, photophobia, tearing, blepharospasm, foreign body sensation, decreased vision, ciliary injection, iris injection, etc. Western medicine usually uses slit-lamp fluorescein staining and corneal scraping examination. The morphology, transparency, and epithelial integrity of the cornea are observed under a slit-lamp microscope. Sodium fluorescein is instilled into the conjunctival sac to observe corneal epithelial defects or ulcers. Combined with microscopic examination or microbial culture of corneal scrapings, the type of pathogen is identified.

[0082] (5) Cataracts: The "Expert Consensus on Cataract Health Management Process (2024)" and "Care of the Adult Patient with Cataract" indicate that early clinical manifestations of cataracts include blurred vision, decreased night vision, double vision, glare and halos, changes in color vision, refractive changes (increased myopia or decreased hyperopia), decreased contrast sensitivity, and visual field defects. Cataracts can be detected using visual acuity tests, cycloplegic fundus examinations, slit-lamp microscopy, and contrast sensitivity and glare tests to assess the type, degree, and presence of other eye diseases. If lens opacity is found and decreased vision cannot be improved by refractive correction, a diagnosis of cataracts is made.

[0083] 3. Method of using the composition

[0084] The Dai medicine composition described in this invention is used externally. The dosage of each herb in the formula can be adjusted within the scope of protection of this invention, depending on the patient's condition. Take 5g of the prepared Dai medicine composition, prepare it according to the method described in Example 9, and then apply it to the eyes. The treatment ends after 20 minutes. Treatment is performed once daily, with 49 applications per treatment cycle.

[0085] 4. Evaluation Indicators

[0086] 4.1 Evaluation Indicators for Dai Medicine

[0087] After treatment, the patient's wind (qi) tower was stable, with no abnormal symptoms such as aversion to wind or headache; the fire tower was normal, with no symptoms of heat such as bitter taste in the mouth, dry throat, or irritability; the water tower was harmonious, with normal eye secretions and body fluid metabolism; and the earth tower was in harmony, with normal digestive function and no abdominal distension or loose stools. From the perspective of Dai medicine, smooth flow of qi and blood is crucial for eye health. After treatment, the pulse was stable and strong, qi and blood flowed smoothly, and the skin color around the eyes was normal, without any signs of qi and blood stagnation such as cyanosis or ecchymosis, indicating improved qi and blood circulation and good recovery of the eye disease.

[0088] 4.2 Western Medicine Evaluation Indicators

[0089] Myopia: Uncorrected visual acuity is tested using a standard logarithmic visual acuity chart. If the uncorrected visual acuity improves by at least one line, and combined with an optometry examination, the degree of myopia decreases and the refractive state remains stable, then the treatment is considered effective.

[0090] Astigmatism: Uncorrected visual acuity is tested using a standard logarithmic visual acuity chart. If the uncorrected visual acuity improves by at least one line, and combined with an optometry examination, the astigmatism degree decreases and the refractive state remains stable, then the treatment is considered effective.

[0091] Macular degeneration: Effective treatment is indicated by improved vision, measured using a standard logarithmic visual acuity chart, with an improvement of at least one line; a reduction in the size of the central scotoma in the visual field; and a decrease in visual obstruction. Further evidence of effective treatment includes: significantly reduced macular edema and exudation, a return to normal macular structure, a significantly decreased central retinal thickness (CRT) compared to baseline, and improved macular edema; and reduced or absent neovascularization in the macular region as shown by OCT angiography (OCTA).

[0092] Keratitis: Patients experience clearer vision, with uncorrected visual acuity improved by at least one line using a standard logarithmic visual acuity chart. Reduced peripapillary conjunctival hyperemia, improved conjunctival hyperemia, and decreased discomfort symptoms indicate effective treatment. Further examination using a slit-lamp microscope to observe corneal opacity reveals increased corneal transparency, reduced opacity, and a decrease or disappearance of fluorescein-positive areas in the corneal epithelium, indicating effective restoration of corneal epithelial integrity.

[0093] Cataracts: Significant improvement in vision after treatment, with an improvement of at least one line in uncorrected visual acuity using a standard logarithmic visual acuity chart; reduced lens opacity and decreased eye discomfort symptoms, indicate that the treatment is effective.

[0094] The treatment results are shown in Table 1 (Note: A patient usually has multiple symptoms at the same time. The following data are statistically analyzed for each symptom separately).

[0095]

[0096] Application Example 2 – Case Study

[0097] Case 1: Xiao, male, 8 years old, with 200 degrees of myopia, 150 degrees of astigmatism, blurred vision without glasses, and uncorrected visual acuity of 0.4 in both eyes at 5 meters. After using the Dai medicine composition described in Example 1 and the preparation obtained according to Example 9, and after 12 treatments, his uncorrected visual acuity improved to 0.8 in both eyes at 5 meters, with no adverse reactions. His uncorrected vision became clear, and he no longer needed glasses.

[0098] Case 2: Ms. Zhang, 58 years old, suffered from dry eye syndrome, eye fatigue, redness and itching, myopia of 200 degrees, blurred vision without glasses, and uncorrected visual acuity of 0.2 in the right eye and 0.3 in the left eye at 5 meters. Using the Dai medicine composition described in Example 3 and the preparation obtained according to Example 9, after 98 treatments, her uncorrected visual acuity improved to 0.6 in the right eye and 0.8 in the left eye at 5 meters. Her dry eye syndrome was basically relieved, her eyes became brighter, and her uncorrected vision was clear. There were no adverse reactions or discomfort.

[0099] Case 3: Mr. Zhou, male, 24 years old, with myopia of 500 degrees and severe eye strain. His uncorrected visual acuity at 3 meters was 0.4 in the right eye and 0.3 in the left eye. After using the Dai medicine composition described in Example 1 and the preparation obtained according to Example 9, and after 60 treatments, his uncorrected visual acuity at 5 meters improved to 0.6 in both the right and left eyes. There were no adverse reactions, his uncorrected vision was clear, and his eye strain symptoms were significantly improved.

[0100] Case 4: Ms. Yang, 44 years old, had suffered from pterygium for over ten years, resulting in cloudy and dull eyes. She had also been nearsighted for over thirty years, always wearing glasses. Her uncorrected visual acuity at 3 meters was 0.2 in her right eye and 0.15 in her left eye. After 35 treatments using the Dai medicine composition described in Example 2 and the preparation obtained according to Example 9, her uncorrected visual acuity at 5 meters improved to 0.4 in her right eye and 0.3 in her left eye, with no adverse reactions. Her uncorrected vision became clear, and her eyes bright and clear, resolving her blurred vision and pterygium problems.

[0101] Case 5: Ms. Du, 47 years old, with myopia of 675 degrees and astigmatism of 250 degrees, had been nearsighted for over 30 years and had been wearing contact lenses for a long time. She experienced protruding eyeballs, frequent swelling, congestion, dryness, and pain. Her uncorrected visual acuity was 0.1 in both her right and left eyes at 1 meter. After 200 treatments using the Dai medicine composition described in Example 2 and the preparation obtained according to Example 9, her uncorrected visual acuity improved to 0.8 in both her right and left eyes at 5 meters. She experienced no adverse reactions, no longer needed glasses, and had clear vision. All her symptoms, including protruding eyeballs, swelling, and dryness, were completely improved.

[0102] Case 6: Ms. Li, 54 years old, suffered from congenital retinitis pigmentosa and night vision impairment. Acupuncture and traditional Chinese medicine treatments failed to improve her symptoms; her uncorrected visual acuity was 0.1 in both eyes at 1 meter. After 25 treatments using the Dai medicine composition described in Example 7 and the preparation obtained according to Example 9, her uncorrected visual acuity improved to 0.5 in both eyes at 1 meter, with no adverse reactions. Her vision became clearer, and her night vision impairment improved.

[0103] Case 7: Mr. Zhang, male, 48 years old, suffered from central retinal artery occlusion, resulting in blindness and loss of light perception in his right eye. Acupuncture, Western medicine, and traditional Chinese medicine failed to improve his symptoms. His uncorrected visual acuity was 1.5 at 5 meters in his left eye (with blindness in his right eye). After 147 treatments using the Dai medicine composition described in Example 6 and the preparation obtained according to Example 9, his uncorrected visual acuity improved to 2.0 at 5 meters in his left eye, and his right eye's light perception significantly improved, allowing him to vaguely see some shadows. His uncorrected visual field broadened, and his visual acuity gradually improved without any adverse reactions.

[0104] Case 8: Chen, male, 7 years old, suffered from keratitis, with burning, stinging, and tearing in his eyes. Eye drops could not relieve his condition. His uncorrected visual acuity was 0.6 in both eyes at 5 meters. After one treatment with the Dai medicine composition described in Example 4 and the preparation obtained in Example 9, his uncorrected visual acuity improved to 1.0 in both eyes at 5 meters and 0.8 in both eyes. His eyes were no longer red, were bright and comfortable, and he experienced no pain or adverse reactions.

[0105] Case 9: Ms. Liao, 58 years old, suffered from floaters and presbyopia, with numerous black shadows in her field of vision affecting her eyesight. Her uncorrected visual acuity at 5 meters was 0.4 in her right eye and 0.25 in her left eye. After using the Dai medicine composition described in Example 5 and the preparation obtained according to Example 9, and after 20 treatments, her uncorrected visual acuity at 5 meters improved to 0.8 in her right eye and 0.6 in her left eye. The black shadows almost disappeared, her uncorrected visual acuity became clear, and there were no adverse reactions.

[0106] Case 10: Ms. Wu, 75 years old, suffered from cataracts, experiencing blurred vision, and her condition continued to worsen. Her uncorrected visual acuity at 5 meters was 0.8 in both her right and left eyes. After using the Dai medicine composition described in Example 7 and the preparation obtained according to Example 9, and after 9 treatments, her uncorrected visual acuity at 5 meters improved to 1.0 in both her right and left eyes. Her vision became clear, her eyes felt comfortable and bright, and there were no adverse reactions.

[0107] Case 11: Ms. Cheng, female, 13 years old, presented with red, swollen eyes, photophobia, tearing, and stinging sensation. Her uncorrected visual acuity at 5 meters was 0.3 in her right eye and 0.8 in her left eye. After two treatments using the Dai medicine composition described in Example 4 and the preparation obtained according to Example 9, her uncorrected visual acuity improved to 0.6 in her right eye and 1.2 in her left eye at 5 meters. The problems of red, swollen eyes and photophobia were resolved, and her vision became clearer without any adverse reactions.

[0108] Case 12: Ms. Liu, 42 years old, suffered from blepharitis, with burning, itchy, and irritating eyelids. Her uncorrected visual acuity was 1.0 in both eyes at 5 meters. After using the Dai medicine composition described in Example 4 and the preparation prepared according to Example 9, her uncorrected visual acuity improved to 1.2 in both eyes at 5 meters after 3 treatments. Her eyes felt comfortable, without burning or stinging sensations, and her vision became clearer. There were no adverse reactions.

[0109] Case 13: Ms. Chen, female, 37 years old, suffered from itchy eyes and had been using eye drops for many years without relief. Her uncorrected visual acuity at 5 meters was 0.12 in her right eye and 0.4 in her left eye. After using the Dai medicine composition described in Example 3 and the preparation prepared according to Example 9, her uncorrected visual acuity at 5 meters improved to 0.5 in her right eye and 1.0 in her left eye. Her itchy eyes were resolved, her eyes were bright and comfortable, and her vision was clearer without any adverse reactions.

[0110] Case 14: Ms. Huang, 75 years old, suffered from macular degeneration, experiencing distorted vision, congestion, edema, stinging, itching, photophobia, tearing, burning, and extremely blurred vision. Her uncorrected visual acuity was 0.1 in her right eye at 1 meter and 0.6 in her left eye at 5 meters. After using the Dai medicine composition described in Example 8 and the preparation obtained according to Example 9, and after 25 treatments, her uncorrected visual acuity improved significantly. Her distorted vision improved, her vision became clearer, her eye discomfort symptoms were basically relieved, her eyes became bright and comfortable, and her uncorrected vision became clearer. There were no adverse reactions.

[0111] The specific embodiments of the present invention have been described above. It should be understood that the present invention is not limited to the specific embodiments described above, and those skilled in the art can make various modifications or variations within the scope of the claims, which do not affect the essence of the present invention.

Claims

1. A Dai medicine composition for treating eye diseases, characterized in that, By weight, it consists of the following components: chrysanthemum 90-100 parts, celosia seed 90-100 parts, cicada molting 90-100 parts, asarum 50-80 parts, imperata root 50-80 parts, vine 50-80 parts, honey 25-45 parts, wild licorice 25-45 parts, and honey 5-10 parts, wherein the honey is the leaf of Artocarpusheterophyllus Lam., a plant of the Moraceae family.

2. The Dai medicine composition for treating eye diseases according to claim 1, characterized in that, By weight, it consists of the following components Composition: Chrysanthemum 90-97 parts, Celosia argentea 90-97 parts, Cicada molting 90-97 parts, Asarum 50-70 parts, Imperata cylindrica root 50-70 parts, Phellodendron chinense 50-70 parts, Honey 25-40 parts, Licorice 25-40 parts, Honey 5-8 parts.

3. The Dai medicine composition for treating eye diseases according to claim 2, characterized in that, By weight, it consists of the following components: chrysanthemum 90-95 parts, celosia seed 90-95 parts, cicada molting 90-95 parts, asarum 50-60 parts, imperata root 50-60 parts, scutellaria barbata 50-60 parts, honey 25-35 parts, wild licorice 25-35 parts, and honey 5-6 parts.

4. The formulation of the Dai medicine composition for treating eye diseases according to any one of claims 1 to 3, characterized in that, The formulation is prepared by adding pharmaceutically acceptable excipients to the Dai medicine composition for treating eye diseases.

5. The formulation of the Dai medicine composition for treating eye diseases according to claim 4, characterized in that, It is made by the following steps: Weigh the medicinal materials and place them in a ventilated room. Grind the medicinal materials other than honey into coarse powder, mix them evenly, and then mix the honey with the mixed powder in equal amounts. Add 40°C warm water according to the weight ratio of mixture:water = 1:4, and stir until it becomes viscous.

6. The application of the Dai medicine composition for treating eye diseases according to any one of claims 1 to 3, characterized in that, The Dai medicine composition for treating eye diseases is used in the preparation of medicines for treating eye fatigue, myopia, astigmatism, floaters, macular degeneration, pterygium, keratitis, blepharitis, cataracts, dry eye, retinitis pigmentosa, central retinal artery occlusion, and / or improving dry eyes, itchy eyes, photophobia, swelling, and presbyopia.

7. The application of the formulation of the Dai medicine composition for treating eye diseases according to claim 4, characterized in that, The formulation of the Dai medicine composition for treating eye diseases is used in the preparation of medicines for treating eye fatigue, myopia, astigmatism, floaters, macular degeneration, pterygium, keratitis, blepharitis, cataracts, dry eye, retinitis pigmentosa, central retinal artery occlusion, and / or improving dry eyes, eye irritation, itchy eyes, photophobia, swelling, and presbyopia.

Images