External Chinese herbal medicine essential oil combined liquid medicine applied to diabetic eye diseases and heart diseases

Abstract

The external Chinese herbal medicine essential oil combined liquid medicine is characterized by being prepared from the following Chinese herbal medicine essential oil: rhizoma arisaematis, radix zanthoxyli, semen strychni, radix aconiti carmichaeli, herba ephedrae, kadsura pepper stem, rhizoma corydalis, pogostemon cablin, ligusticum wallichii, ginger, radix cynanchi paniculati, artemisia anomala, radix angelicae, melissa officinalis, cinnamon, mint and safflower carthamus. The traditional Chinese medicine has the effects of relaxing tendons and activating collaterals, promoting blood circulation to remove blood stasis and relieving swelling and pain; the traditional Chinese medicine composition has the effects of being high in medicine efficacy permeability, rapid in effect taking and capable of rapidly relieving the illness state, and can be used for preparing external application for treating diabetic eye diseases and heart diseases such as heart diseases, coronary heart diseases, heart discomfort or pain, stuffiness pain, angina pectoris, neck arteriosclerosis, plaques and static arterial thrombosis in cardiovascular and cerebrovascular diseases. The external medicine is used for relieving swelling and pain, soothing channels and activating collaterals, and promoting blood circulation to remove blood stasis. The invention provides a convenient, rapid and effective external medicine treatment mode for patients with the diseases.

Description

Technical Field

[0001] This invention belongs to the field of pure traditional Chinese medicine technology research and application, and is a technological achievement in the field of external treatment drugs for diabetic eye disease (diabetic retinopathy) and heart disease. Specifically, it involves an external medicine for diabetic eye disease, cardiovascular and cerebrovascular diseases, and related conditions such as coronary heart disease, heart discomfort or pain, dull pain, angina, carotid artery sclerosis, plaque, venous artery thrombosis, or cervical, lumbar, and leg joint pain, which has the effects of reducing swelling and relieving pain, soothing the meridians and activating blood circulation, and removing blood stasis.

[0002] The current effective treatment for diabetic retinopathy is surgery, and there are no dedicated topical medications available. Similarly, topical medications for heart disease or coronary heart disease causing discomfort or pain are extremely scarce. While nitroglycerin patches exist in Western medicine, their penetration is poor, their onset of action is slow, and they only dilate blood vessels, lacking the blood-activating, stasis-removing, and meridian-clearing effects of traditional Chinese medicine. Therefore, in the field of topical medications for the prevention and treatment of diabetic retinopathy and heart disease / coronary heart disease causing discomfort or pain, the development of fast-acting topical medications based on traditional Chinese medicine is imperative. This invention fills the gap in the development of topical traditional Chinese medicine treatments for diabetic retinopathy and heart disease in my country.

[0003] The technology of this invention utilizes the aromatic volatile medicinal components of traditional Chinese medicine to promote blood circulation, remove blood stasis, fight bacteria, reduce swelling and relieve pain, promote blood circulation, and have strong penetrating power, so that the medicine can be directly absorbed, the efficacy can be quickly exerted, and it can have a direct therapeutic effect on the lesions at the site of the disease. Background Technology

[0004] Diabetic eye disease is a complication of diabetes, also known as "diabetic retinopathy". In traditional Chinese medicine, it is a disease caused by phlegm and dampness obstructing the meridians. It is caused by phlegm and dampness blocking the meridians, leading to deficiency of both yin and yang, resulting in eye disease of thirst. The TCM disease name is: thirst eye disease.

[0005] Aside from congenital conditions, the vast majority of heart discomfort or pain is caused by cardiovascular and cerebrovascular diseases, a condition known in Traditional Chinese Medicine (TCM) as "true heart pain." Heart discomfort or pain is increasingly affecting younger people today, with many young people losing their lives due to sudden cardiac arrest caused by heart pain. Although there are many pathological causes of heart discomfort or pain, the underlying symptoms are often insufficient blood supply to the heart, leading to myocardial ischemia and myocardial damage. In TCM diagnosis, this is characterized by impaired blood and qi flow and blood stasis, which is classified as blood stasis syndrome in TCM theory.

[0006] Blood stasis syndrome: With changes in people's lifestyles and dietary habits, the incidence of cardiovascular and cerebrovascular diseases is increasing, including coronary heart disease, myocardial infarction, arterial thrombosis, and arteriosclerosis. The incidence of these diseases is on the rise and remains high, seriously threatening human health. The pathological basis of these diseases is often closely related to atherosclerosis, gradual narrowing of blood vessels, calcification, fibrosis, and vascular thrombosis.

[0007] Arterial stenosis and arteriosclerosis refer to arteriosclerotic diseases characterized by thickening, hardening, and decreased elasticity of the arterial walls. They begin with lipid deposition and atherosclerosis within the blood vessels. Atherosclerosis is caused by the oxidation, calcification, or fibrosis of lipid deposits in the blood vessel walls, or by the combined effects of multiple factors such as platelets and free radicals. Arterial stenosis and arteriosclerosis are among the most common and dangerous diseases.

[0008] Vascular thrombosis is caused by inflammation resulting from damage to the vascular endothelium due to high blood pressure; or by toxins remaining in the blood after bacterial or viral infection; or by platelet aggregation caused by vascular trauma; or by blood viscosity, poor blood flow, and oxidation leading to thrombosis.

[0009] Arterial stenosis, arteriosclerosis, plaque, and vascular thrombosis are most common in the carotid arteries, coronary arteries, middle cerebral artery, subclavian artery, and lower limb venous arteries.

[0010] Aside from a very small number of cases with genetic factors, coronary heart disease is mostly caused by coronary atherosclerosis, lipid deposition, oxidation, calcification, and fibrosis, which lead to narrowing and blockage of the coronary arteries, resulting in insufficient blood supply to the coronary arteries, myocardial ischemia and hypoxia, thus causing heart discomfort, dull pain, pain, angina, and then progressing to myocardial damage, myocardial fibrosis, sclerosis, and finally heart failure.

[0011] These are all symptoms and causes of blood stasis syndrome, which is characterized by poor blood circulation and blockage of blood vessels and meridians.

[0012] In traditional Chinese medicine, neck, back, and leg joint pain is classified as Bi syndrome.

[0013] Bi syndrome: The progression of Bi syndrome is numbness → blood stasis → blockage → numbness → pain. Although Bi syndrome and blood stasis syndrome differ in their causes, they are both caused by poor blood circulation and obstruction of meridians and collaterals.

[0014] Therefore, in the diagnosis and prescription pharmacology of traditional Chinese medicine, these diseases can be treated with the same method for different diseases.

[0015] In our company's traditional Chinese medicine research and development project, the invention patent applied for some time ago (application number 202510569437.5) is the invention of an oral therapeutic drug for treating these diseases.

[0016] The invention applied for this time is the invention of a topical medicine for treating these diseases.

[0017] External application of traditional Chinese medicine is a type of treatment that directly targets the lesions and symptoms.

[0018] In modern medicine, topical medications are often considered an adjunct therapy; the root cause of the disease remains, and treatment should focus on internal conditioning and regulation of the body. Traditional Chinese medicine, however, uses external therapies based on syndrome differentiation to target and treat specific symptoms of certain diseases.

[0019] In traditional Chinese medicine (TCM) theory, disease formation involves three stages: "etiology," "symptoms," and "disease progression." Regarding "etiology," TCM practitioners identify the cause and evidence of the disease's onset, analyze the current symptoms, and predict its future course to implement precise medication. "Etiology" is a colloquial term; ancient physicians referred to it as "disease pattern," which is the evidence and cause of the disease. Therefore, TCM diagnosis employs two theories: "syndrome differentiation and treatment" and "symptom differentiation and treatment." "Syndrome" and "symptom" should not be interpreted as interchangeable characters. Both "syndrome differentiation and treatment" and "symptom differentiation and treatment" are unified yet subdivided foundations of TCM diagnostics, which can be understood as "treating the cause if the cause is known, and treating the symptoms if the cause is unknown." This is the theoretical basis for external treatment of diseases in TCM culture, as well as the theoretical basis for individualized prescriptions, the use of the same prescription for different diseases, and general prescriptions in TCM.

[0020] External treatment techniques can effectively achieve clinical cure by eliminating symptoms or effectively curbing the progression of the disease in the early and middle stages of the illness. In cases where the condition is more severe, external treatment is an extremely effective adjunctive treatment that can alleviate the patient's symptoms.

[0021] The development of modern medical diagnostic technology makes it easier to pinpoint the lesion site with topical Chinese herbal medicines, and to directly target the lesion using the permeability technology of Chinese herbal medicines.

[0022] Diabetic retinopathy, coronary heart disease with heart discomfort or pain, carotid artery sclerosis, plaques, thrombosis, or cervical, lumbar, and leg joint pain—these conditions can be prevented and treated with topical Chinese herbal medicine in their early and middle stages. Most patients can achieve clinical cure with symptom disappearance or have their condition further progressed. It can also be used as an adjunct therapy to improve efficacy in the middle and later stages of these conditions.

[0023] Currently, diabetic retinopathy is primarily treated surgically, with virtually no topical medications available. Similarly, topical medications for cardiovascular diseases such as heart disease, coronary heart disease, and heart discomfort or pain are also scarce. While Western medicine offers nitroglycerin patches, their penetration is poor, their onset of action is slow, and they only dilate blood vessels, lacking the blood-activating, stasis-removing, and meridian-clearing effects of traditional Chinese medicine. Therefore, in the field of topical medications for the prevention and treatment of diabetic retinopathy, heart disease, coronary heart disease, and heart discomfort and pain, the development of fast-acting topical Chinese medicines is imperative.

[0024] Diabetic retinopathy, coronary heart disease, heart discomfort or pain, carotid artery sclerosis, plaques, thrombosis, or neck, waist and leg joint pain—these conditions can all be treated by applying topical medications to penetrate the affected area.

[0025] Herbal essential oil-based medicinal liquids have high levels of active medicinal ingredients, which are volatile aromatic compounds. They are fast-acting and have strong penetrating power.

[0026] External application of herbal essential oils and liquids for treatment utilizes the pharmacological properties of the aromatic volatile components contained in Chinese herbs. By taking advantage of their strong penetrating power, rapid penetration, and quick absorption, they can achieve a rapid therapeutic effect.

[0027] Of course, heart discomfort or pain can also be caused by other specific underlying conditions, such as acute damage to the heart from pleural effusion compressing it, or myocardial damage caused by lung infection. In Traditional Chinese Medicine (TCM), the principles of "differentiation of syndromes and treatment based on syndrome differentiation" emphasize promoting blood circulation, reducing swelling and pain, clearing the meridians, and improving blood flow—areas where TCM excels. External application of herbal medicines, with their penetrating and direct effects, is more conducive to rapid control of the condition or recovery.

[0028] External application of traditional Chinese herbal medicine is a traditional treatment method in Chinese medicine for cervical spine and lower back and leg joint pain. Summary of the Invention

[0029] A topical herbal essential oil combination solution for diabetic retinopathy and heart disease, specifically relating to a topical medicine for diabetic retinopathy and cardiovascular diseases, specifically for heart discomfort or pain, dull pain, colic, carotid artery sclerosis, plaque, venous arterial thrombosis, or cervical, lumbar, and leg joint pain, characterized by its preparation from herbal essential oils in the following weight proportions. Arisaema heterophyllum 3-12 parts, Zanthoxylum nitidum 6-16 parts, Strychnos nux-vomica 5-18 parts, Aconitum carmichaelii 4-12 parts, Ephedra sinica 2.5-9 parts, Piper kadsura 8-22 parts, Corydalis yanhusuo 9-19 parts, Pogostemon cablin 9-17 parts, Ligusticum chuanxiong 6-14 parts, Zingiber officinale 7-16 parts, Cynanchum paniculatum 5-21 parts, Artemisia capillaris 7-25 parts, Angelica dahurica 7-21 parts, Lemon balsamina 5-19 parts, Cinnamomum cassia 4-16 parts, Mentha haplocalyx 2-8 parts, Carthamus tinctorius 25-145 parts.

[0030] Furthermore, this herbal essential oil combination liquid is prepared from essential oils extracted from the following Chinese herbs: Arisaema heterophyllum, Zanthoxylum nitidum, Strychnos nux-vomica, Aconitum carmichaelii, Ephedra sinica, Piper kadsura, Corydalis yanhusuo, Pogostemon cablin, Ligusticum chuanxiong, Zingiber officinale, Cynanchum paniculatum, Artemisia capillaris, Angelica dahurica, Lemon balm, Cinnamomum cassia, Mentha haplocalyx, and Carthamus tinctorius.

[0031] Furthermore, it is a preparation made by adding acceptable excipients or auxiliary ingredients to the herbal essential oil combination solution.

[0032] Furthermore, the formulation is characterized in that it can be any dosage form of a drug, or a dosage form of a health product, a product with a disinfection license, a cosmetic product, or a pure essential oil aromatherapy care product.

[0033] This invention also provides the use of the aforementioned combination of essential oils extracted from traditional Chinese medicines in the preparation of topical medicines for diabetic retinopathy, cardiovascular and cerebrovascular diseases such as coronary heart disease, heart discomfort or pain, dull pain, angina, atrial fibrillation, carotid artery sclerosis, plaque, venous artery thrombosis, or lumbar and cervical joint pain, for the purpose of reducing swelling and relieving pain, soothing the meridians and activating blood circulation, and removing blood stasis.

[0034] Traditional Chinese medicine uses different principles for the combination of external medicines compared to internal medicines. Internal medicines are combined according to the principle of principal, assistant, adjuvant and guide, while external medicines are combined according to the principle of reducing swelling and relieving pain, promoting blood circulation and removing blood stasis, breaking up numbness and dissipating nodules, clearing heat and detoxifying, and unblocking meridians.

[0035] Arisaema essential oil: Extracted from fresh Arisaema herb through extraction and distillation processes;

[0036] Arisaema, which enters the lung, liver and spleen meridians, has a bitter and pungent taste. Its functions and indications are to dry dampness and resolve phlegm, dispel wind and stop spasms, disperse nodules and reduce swelling, and treat facial paralysis and hemiplegia. Here, this effect is used to treat phlegm and dampness and stagnation in the meridians and blood vessels.

[0037] Two-sided needle essential oil: It is extracted from fresh two-sided needle leaves and stems through extraction and distillation processes;

[0038] Zanthoxylum nitidum enters the liver and stomach meridians. Its properties are bitter, pungent, neutral, and slightly toxic. Its functions and indications include promoting qi circulation and relieving pain, invigorating blood circulation, removing blood stasis, dispelling wind, and unblocking the meridians. Its pharmacological effects include analgesia and anti-inflammation, inhibiting inflammation, reducing inflammatory responses, and treating burns while reducing scar formation. Pharmacological studies have shown it has a cardioprotective effect, reducing the release of myocardial enzymes during myocardial ischemia-reperfusion injury, protecting myocardial cells. Additionally, it promotes tissue regeneration and repair of injured tissue cells caused by meridian blockage.

[0039] Strychnos nux-vomica essential oil: It is made from dried strychnos nux-vomica that has been peeled and defuzzed, processed, pulverized, and then extracted using an extraction process;

[0040] Strychnos nux-vomica, enters the liver and spleen meridians. It is bitter and warm in nature, and is toxic (its toxicity is determined by dosage; small amounts stimulate the heart rate and raise blood pressure. The seed coat and villi are the main toxic components; processing reduces their toxicity. When used externally, the dosage is extremely small and will not cause toxic reactions). Its functions and indications include clearing the meridians and relieving pain, dispersing nodules and reducing swelling. It is used for stubborn rheumatic pain, numbness and paralysis, carbuncles, sequelae of poliomyelitis, and rheumatoid arthritis.

[0041] Aconite essential oil: It is made from dried aconite that has been processed and then extracted using an extraction process.

[0042] Aconite root enters the heart, kidney, and spleen meridians; it is pungent, sweet, and very hot in nature, and is toxic (its toxicity is determined by dosage; when used externally, the therapeutic dose is extremely small and will not cause toxic reactions). In prescriptions, aconite root is often used in combination with ginger to reduce its toxicity. Its functions and indications include restoring yang and rescuing from collapse, tonifying fire and assisting yang, dispelling cold and dampness, and it is clinically used to treat heart failure.

[0043] Ephedra essential oil: It is extracted from fresh ephedra through an extraction and distillation process;

[0044] Ephedra is warm and moist in nature. It enters the lung and bladder meridians with a slightly bitter taste. Its functions include inducing sweating to relieve exterior syndromes, clearing the lungs and relieving asthma, and promoting diuresis and reducing swelling. It is an essential medicine for relieving exterior syndromes and has the effect of opening up the terminal channels of capillaries. Modern pharmacological research shows that it has antipyretic, analgesic, anti-inflammatory, central nervous system stimulant, blood pressure raising, and heart rate accelerating effects. It is mainly used to treat chest tightness, cough and wheezing, rheumatic pain, and carbuncles.

[0045] Seaweed essential oil: Extracted from fresh seaweed through extraction and distillation processes;

[0046] Piper kadsura, entering the liver meridian, is pungent, bitter, and slightly warm in nature. Its functions and indications include dispelling wind and dampness, unblocking meridians, and relieving pain. It is used for wind-cold-dampness arthralgia, joint pain, and meridian contracture. Pharmacologically, it can enhance myocardial nutrient flow and has good therapeutic effects on coronary heart disease and cerebral thrombosis.

[0047] Corydalis essential oil: It is extracted from dried Corydalis through an extraction and distillation process;

[0048] Corydalis rhizome enters the liver and spleen meridians. Its functions and indications include promoting blood circulation, regulating qi, and relieving pain, and it is used for various types of arthralgia. Pharmacologically, it can dilate coronary arteries and increase blood supply to the heart.

[0049] Patchouli essential oil: Extracted from fresh patchouli stems and leaves using an extraction and distillation process;

[0050] Patchouli enters the spleen and stomach meridians. It is pungent and slightly warm in nature. Its functions and indications include aromatically clearing away turbidity, releasing exterior pathogens, and relieving summer heat. Pharmacologically, the active ingredients in its volatile oil can inhibit ACF enzyme activity and reduce angiotensin II levels, thereby altering vascular endothelial function. Its patchouli diterpenoid lactone has a unique antiarrhythmic effect. Its aromatic ability to relieve exterior pathogens and clear away turbidity can open up circulation at the ends of blood vessels, thereby clearing the meridians.

[0051] Ligusticum chuanxiong essential oil: It is extracted from fresh Ligusticum chuanxiong roots, stems and leaves through extraction and distillation processes;

[0052] Chuanxiong (Ligusticum striatum) enters the liver, gallbladder, and pericardium meridians. It is pungent and warm in nature. Its functions and indications include promoting blood circulation, regulating qi, dispelling wind, and relieving pain. Its pharmacological effects include dilating coronary arteries to increase myocardial blood supply, reducing myocardial ischemia damage, and inhibiting the formation of atherosclerotic plaques.

[0053] Ginger essential oil: Extracted from fresh ginger through an extraction and distillation process;

[0054] Ginger enters the lung, spleen, and stomach meridians. It is pungent and slightly warm in nature, and can relieve exterior syndromes, dispel cold, and resolve phlegm. Its main function here is to promote blood circulation.

[0055] Cynanchum paniculatum essential oil: It is extracted from fresh Cynanchum paniculatum roots, stems and leaves through extraction and distillation processes;

[0056] Xu Changqing enters the liver and stomach meridians. It is pungent and warm in nature. Its functions and indications are to dispel wind and dampness, relieve pain and itching, promote diuresis and reduce swelling, invigorate blood and detoxify. It is often used for rheumatic pain.

[0057] Artemisia annua essential oil: It is extracted from fresh Artemisia annua roots, stems and leaves through extraction and distillation processes;

[0058] Liu Ji Nu enters the heart, liver, and spleen meridians. It is pungent, warm, and slightly bitter in nature. Its functions and indications include breaking up blood stasis and promoting menstruation, stopping bleeding and reducing swelling. When taken internally, it is used to treat amenorrhea, abdominal masses, and acute infectious hepatitis.

[0059] Angelica dahurica essential oil: extracted from dried Angelica dahurica through extraction and distillation processes.

[0060] Angelica dahurica, with its pungent and warm properties, enters the lung, spleen, and stomach meridians. Its functions include dispelling wind and dampness, reducing swelling and draining pus to promote tissue regeneration, and relieving pain. Clinically, it is used to treat headaches, toothaches, trigeminal neuralgia, and abdominal pain.

[0061] Lemon balm oil: Extracted from fresh lemon balm using an extraction and distillation process;

[0062] Lemon balm, also known as honey bee flower, lemon balm, peppermint balm, and balm grass in traditional Chinese medicine, has sedative and digestive effects. Pharmacologically, it has antiviral effects and a certain inhibitory effect on herpes virus. Here, we take advantage of its aromatic medicinal properties for its calming and antibacterial effects.

[0063] Cinnamon essential oil: It is extracted from dried cinnamon bark through an extraction and distillation process;

[0064] Cinnamon enters the kidney, spleen, heart, and liver meridians. It is pungent and sweet in nature and has the functions of dispelling cold and relieving pain, promoting blood circulation and unblocking collaterals, and tonifying fire and assisting yang. It is used for cold pain in the waist and legs, amenorrhea, and cold pain in the heart and abdomen.

[0065] Peppermint essential oil is extracted from fresh peppermint leaves using an extraction and distillation process.

[0066] Peppermint, with its pungent taste and cool nature, is used for wind-heat colds, sore throats, canker sores, and toothaches. It has antibacterial and antiviral effects, as well as antipruritic effects. Pharmacologically, it dilates blood vessels, relaxes vascular smooth muscle, improves blood flow, and enhances the penetration of drugs into tissue cells.

[0067] Safflower essential oil: Extracted from fresh safflower using an extraction and distillation process;

[0068] Safflower enters the heart and liver meridians. It is pungent and warm in nature, and its functions include promoting blood circulation, regulating menstruation, dispersing blood stasis, and relieving pain. Its essential oil is often used as a base diluent for topical Chinese herbal medicines.

[0069] This invention is formulated using drugs that reduce swelling and pain, promote blood circulation and remove blood stasis, break up numbness and dissipate nodules, clear heat and detoxify, and dredge the meridians, combined with the pharmacological properties of the volatile components of traditional Chinese medicine. It utilizes the strong penetrating power of the volatile components of traditional Chinese medicine, namely the essential oils of these herbs, to achieve topical drug penetration therapy at the site of the lesion.

[0070] Herbal essential oils are mainly divided into two types: pure essential oils, which are insoluble in water; and water-soluble essential oils, which are soluble in water. (Of course, there is also a type of substance that is extracted from herbal essential oils using further technological means.)

[0071] Water-soluble essential oils are essential oils with added pharmaceutical or food-grade additives, such as those using Tween 80 or PEG-60 hydrogenated castor oil to enhance their water solubility. Water-soluble essential oils are raw materials for preparing aqueous pharmaceutical solutions.

[0072] The essential oil raw materials used in this invention are all domestically produced and commercially available products that meet relevant national standards, obtained through critical extraction and steam distillation. Therefore, this invention does not limit the source of the raw materials. However, the herbal essential oils used in this invention are supplied by manufacturers with whom the company has stable cooperation.

[0073] Compared with the prior art, the beneficial effects and advantages of the present invention are as follows:

[0074] The technical advantages of this invention are that it is a pure herbal external application formula, which is convenient to prepare and apply. It is relatively safe, can prevent and treat diseases, and has a rapid onset of action; most patients with early-stage symptoms can achieve clinical cure with symptom disappearance. In cases of more severe symptoms, it can be used in conjunction with internal medications to achieve a rapid auxiliary effect of treatment or to inhibit or halt the progression of the disease. It can prevent and treat diabetic retinopathy and cardiovascular diseases such as coronary heart disease, heart discomfort or pain, dull pain, angina, carotid artery sclerosis, plaques, venous thrombosis, or neck, back, and leg joint pain. It has extremely high medicinal and socioeconomic value. Detailed Implementation

[0075] A topical herbal essential oil combination solution for diabetic retinopathy and heart disease, specifically relating to a topical medicine for diabetic retinopathy and cardiovascular diseases, specifically for heart discomfort or pain, dull pain, colic, carotid artery sclerosis, plaque, venous arterial thrombosis, or cervical, lumbar, and leg joint pain, characterized by its preparation from herbal essential oils in the following weight proportions. Arisaema heterophyllum 3-12 parts, Zanthoxylum nitidum 6-16 parts, Strychnos nux-vomica 5-18 parts, Aconitum carmichaelii 4-12 parts, Ephedra sinica 2.5-9 parts, Piper kadsura 8-22 parts, Corydalis yanhusuo 9-19 parts, Pogostemon cablin 9-17 parts, Ligusticum chuanxiong 6-14 parts, Zingiber officinale 7-16 parts, Cynanchum paniculatum 5-21 parts, Artemisia capillaris 7-25 parts, Angelica dahurica 7-21 parts, Lemon balsamina 5-19 parts, Cinnamomum cassia 4-16 parts, Mentha haplocalyx 2-8 parts, Carthamus tinctorius 25-145 parts.

[0076] Among them, the point value of Arisaema essential oil by weight is not limited to any one of 3 to 12 parts or any range between two parts.

[0077] Among them, the point value of the two-sided needle essential oil by weight is not limited to any one of 6 to 16 parts or any range between two.

[0078] Among them, the nux vomica essential oil, by weight, includes but is not limited to the point value of any one of 5 to 18 parts or the range between any two.

[0079] The aconite essential oil, by weight, includes, but is not limited to, the point value of any one of 4 to 12 parts or the range between any two.

[0080] Among them, the ephedra essential oil, by weight, includes but is not limited to the point value of any one of 2.5 parts to 9 parts or the range value between any two.

[0081] Among them, the point value of sea breeze vine essential oil by weight is not limited to any one of 8 to 22 parts or any range between two.

[0082] Among them, the point value of Corydalis essential oil by weight is not limited to any one of 9 to 19 parts or any range between two.

[0083] Among them, the patchouli essential oil, by weight, includes, but is not limited to, any one of the point values ​​or any range between 9 and 17 parts.

[0084] The value of Chuanxiong essential oil, by weight, includes, but is not limited to, any one of 6 to 14 parts or any range between two.

[0085] Among them, the ginger essential oil, by weight, includes, but is not limited to, any one of the point values ​​or any range between 7 and 16 parts.

[0086] Among them, the point value of Xu Changqing essential oil by weight is not limited to any one of 5 to 21 parts or any range between two.

[0087] Among them, the Liu Ji Nu essential oil, by weight, includes but is not limited to the point value of any one of 7 to 25 parts or the range between any two.

[0088] Among them, the point value of Angelica dahurica essential oil by weight is not limited to any one of 7 to 21 parts or any range between two.

[0089] Among them, lemon balm essential oil, by weight, includes but is not limited to the point value of any one of 5 to 19 parts or the range between any two.

[0090] The cinnamon essential oil, by weight, includes, but is not limited to, a point value of any one of 4 to 16 parts or a range between any two.

[0091] Among them, peppermint essential oil, by weight, includes but is not limited to the point value of any one of 2 to 8 parts or the range of any two parts.

[0092] Among them, the safflower essential oil, by weight, includes but is not limited to the point value of any one of 25 parts to 145 parts or the range value between any two.

[0093] The method for external application of the herbal essential oil combination solution of the present invention for therapeutic purposes:

[0094] In the external treatment of diabetic retinopathy, the medicinal solution of this invention is applied to the entire brow bone above both eyes and the temples on both sides (Zanzhu, Yuyao, Sizhukong, and Taiyang acupoints). It is crucial not to apply the solution to the upper or lower eyelids and to prevent accidental splashing into the eyes. For the external treatment of coronary heart disease, specifically for heart discomfort, pain, dull pain, or angina, the medicinal solution of this invention is applied directly to the chest area and surrounding area corresponding to the heart, as well as the back area and surrounding area. For the external treatment of carotid artery sclerosis, plaques, and thrombosis, the medicinal solution can be applied to the entire neck, including the cervical spine, and even to all areas of the scalp except the face.

[0095] For pain caused by the cervical and lumbar spine, apply the medication to the corresponding area of ​​the cervical or lumbar spine. For pain in the lower back and leg joints, apply the medication to the affected joint. For other types of pain, apply the medication to the area that hurts.

[0096] In summary, the principle of external application of this invention is: apply it to the area where it is uncomfortable or painful, as long as you are careful not to splash the medicine onto or irritate your eyes.

[0097] The following description of the embodiments is merely to aid in understanding the method and core ideas of the present invention. It should be noted that those skilled in the art can make various improvements and modifications to the present invention without departing from the TCM theory and pharmacology of the invention, and these improvements and modifications also fall within the scope of protection of the claims of the present invention. Therefore, the present invention is not limited to the embodiments shown herein, but can be applied to a wider range consistent with the pharmacology and novel features of TCM prescriptions disclosed herein. Unless otherwise defined, all techniques and TCM terms used herein have the same meaning as commonly understood by those skilled in the art to which this invention pertains.

[0098] Example: Preparation of the medicinal liquid of the herbal essential oil composition of the present invention.

[0099] Formula: 4 parts Arisaema heterophyllum essential oil, 5 parts Zanthoxylum nitidum essential oil, 2 parts Strychnos nux-vomica essential oil, 4 parts Aconitum carmichaelii essential oil, 2.5 parts Ephedra sinica essential oil, 8 parts Piper kadsura essential oil, 10 parts Corydalis yanhusuo essential oil, 9 parts Patchouli essential oil, 6 parts Ligusticum chuanxiong essential oil, 7 parts Zingiber officinale essential oil, 7 parts Cynanchum paniculatum essential oil, 7 parts Artemisia capillaris essential oil, 8 parts Angelica dahurica, 5 parts Lemon balm essential oil, 4 parts Cinnamomum cassia essential oil, 2.3 parts Peppermint essential oil, 25 parts Carthamus tinctorius essential oil, 0.17 parts Vanillyl butyl ether (heat-sensitizing agent).

[0100] Preparation method:

[0101] ① Weigh the above-mentioned Chinese herbal essential oils according to the weight ratio;

[0102] ②Put the mixture into a sealed container at room temperature and stir well;

[0103] ③ Dispense the solution into spray-type packages with a volume of 20ml per bottle;

[0104] ④ Take 1000 bottles and package them for use as the external medicine for the research group in this embodiment, and temporarily name it "Huabi Oil".

[0105] The clinical efficacy observation of the herbal essential oil combination liquid of the present invention in the embodiments was divided into 4 groups: study group 1, study group 2, study group 3, and study group 4.

[0106] From October 2022 to June 2025, our company will collaborate with several health and wellness hospitals and community hospitals to recruit 160 patients as volunteers for the case study group. Volunteer patients are required to adhere to medication and meet the conditions for clinical follow-up. The diagnosis of all volunteer patients will be based on the diagnostic and examination results of tertiary hospitals.

[0107] The 160 volunteer patients were divided into four groups: Study Group 1, Study Group 2, Study Group 3, and Study Group 4. Study Group 1 consisted of 40 patients with type II diabetic retinopathy, receiving treatment for 40 days; Study Group 2 consisted of 40 patients with coronary heart disease and cardiac discomfort, receiving treatment for 60 days; Study Group 3 consisted of 40 patients with carotid artery stenosis, receiving treatment for 40 days; and Study Group 4 consisted of 40 patients with lower back and leg pain, receiving treatment for 30 days. Our company provided all 160 volunteer patients with free external application of "Huabi Oil," and also subsidized the costs of pre- and post-treatment examinations at a top-tier hospital.

[0108] In Study Group 1 of the Example, 40 patients with type II diabetic retinopathy were selected.

[0109] Case inclusion criteria:

[0110] (1) Those who have not undergone surgical treatment and are willing to use topical Chinese medicine;

[0111] (2) Diagnosis of diabetic retinopathy in stages I-II;

[0112] (3) Blood pressure <170 / 100 mmHg at the time of case selection and assessment.

[0113] Exclusion criteria for case selection:

[0114] (1) Pregnant women;

[0115] (2) Those whose blood pressure cannot be controlled in a timely and effective manner or who experience significant fluctuations;

[0116] (3) Has a severe mental disorder;

[0117] (4) Those with severe liver or kidney dysfunction;

[0118] (5) Those who are averse to or allergic to the smell of Chinese medicine.

[0119] The study group consisted of 40 volunteers, including 26 males and 14 females, aged 40–65 years, with a mean age of (45.3±6.1) years. The topical medication course for diabetic retinopathy was 40 days: "Huabi Oil" solution was applied daily in the morning, noon, evening, and before bedtime to the entire brow bone above both eyes and the temples (Zanzhu, Yuyao, Sizhukong, and Taiyang acupoints). It was crucial to avoid applying the solution to the upper and lower eyelids and to prevent accidental splashing into the eyes. Each application consisted of approximately 1 ml. If other hypoglycemic medications were being taken previously, they could continue taking them. A light diet was recommended, avoiding high-fat and high-sugar foods. A follow-up examination was conducted after the 40-day treatment course.

[0120] Clinical efficacy evaluation: Referring to the diagnostic staging criteria for diabetic retinopathy, the disappearance of symptoms in stages I and II is evaluated as clinical cure with symptom disappearance; the reduction or reversal of symptoms in stages I and II is evaluated as clinical effectiveness; and the lack of reduction or progression of symptoms in stages I and II is evaluated as ineffective.

[0121] After 40 days of topical application of "Huabi Oil" to the patients in Group 1, a comparison of the patients' pre- and post-hospital examination results showed that diabetic retinopathy had disappeared in 35 of the 40 patients, and symptoms were reversing and becoming milder in 5 patients, as shown in Table 1.

[0122] Table 1. Efficacy data of topical medication for diabetic retinopathy after 40 days of treatment.

[0123] Experimental group Number of people Clinical symptoms disappeared (number of people) Clinical symptoms reversed or lessened (number of people) Clinical cure rate with symptom disappearance (%) Overall effectiveness (%) Inefficiency (%) Research Group 1 40 35 5 87.5 100 0

[0124] After 40 days of external treatment with "Huabi Oil", the clinical cure rate of symptom disappearance in 40 diabetic retinopathy patients in the study group 1 reached 87.5%, and the total effective rate was 100%.

[0125] Example 2 Study Group: 40 patients with coronary heart disease experiencing cardiac discomfort or pain were selected.

[0126] Case inclusion criteria:

[0127] (1) Receiving traditional Chinese medicine external treatment;

[0128] (2) Average heart rate between 50 and 100;

[0129] (3) Blood pressure <170 / 100 mmHg at the time of selection and assessment;

[0130] (4) No atrial fibrillation or severe T2 dysfunction;

[0131] (5) No hemangioma was detected on whole-body CT scan;

[0132] (6) Diseases with no other obvious embolic embolus source.

[0133] Exclusion criteria for cases:

[0134] (1) History of intracranial hemorrhage and tumor within the past six months;

[0135] (2) History of other bleeding disorders;

[0136] (3) Pregnant women;

[0137] (4) Poor blood glucose control in diabetic patients;

[0138] (5) Those whose blood pressure cannot be controlled effectively and in a timely manner or who experience significant fluctuations;

[0139] (6) Has a severe mental disorder;

[0140] (7) Severe liver and kidney dysfunction;

[0141] (8) Those who are averse to or allergic to the smell of Chinese medicine.

[0142] The study group consisted of 40 volunteers, including 22 males and 18 females, aged 50–70 years, with a mean age of (62.4±6.3) years. The treatment course for patients with coronary heart disease experiencing cardiac discomfort or pain was 60 days: "Huabi Oil" solution was applied to the chest and surrounding areas corresponding to the heart, as well as the back and surrounding areas, morning, noon, evening, and before bedtime, at a dosage of 1–3 ml each time. Patients who were previously taking oral medication could continue during the treatment period. High-fat and high-sugar foods were avoided; a light diet was recommended. The medication was discontinued for 30 days after the 60-day treatment, and patient feedback on symptoms during this 30-day period was collected and statistically analyzed.

[0143] Clinical efficacy evaluation: Based on the feedback from patients regarding their symptoms during the 30-day period after stopping the medication following a 60-day treatment course, and with reference to the comparison of pre- and post-treatment examination results from the hospital, the evaluation criteria were as follows: if no cardiac discomfort or pain occurred during the 30-day period after stopping the medication, it was evaluated as clinical cure with symptom disappearance; if the frequency and number of cardiac discomfort and pain attacks decreased during the 30-day period after stopping the medication, it was evaluated as clinically effective; if the volunteer patient felt no change in cardiac discomfort or pain during the use of "Huabi Oil", the volunteer patient automatically withdrew from the study group, and was evaluated as ineffective.

[0144] After a 60-day treatment course, medication was stopped for 30 days. During this 30-day period, patient feedback on symptoms was collected, and the results of pre- and post-treatment examinations at the hospital were compared and statistically analyzed, as shown in Table 2.

[0145] Table 2. Efficacy data of topical medication treatment for patients with coronary heart disease experiencing cardiac discomfort or pain within 30 days after discontinuation after 60 days of treatment.

[0146] Experimental group Number of people Discomfort or pain symptoms disappeared (number of people) The frequency of discomfort or pain has decreased (number of people) Number of people who withdrew Clinical cure rate with symptom disappearance (%) Effectiveness (%) Inefficiency (%) Research Group 2 40 31 9 0 77.5 100 0

[0147] In study group 2, after applying "Huabi Oil" topically for 60 days and then stopping the medication for 30 days, 31 out of 40 patients experienced a complete disappearance of their heart discomfort and pain, and 9 patients saw a reduction in the frequency and severity of their heart discomfort and pain. The clinical cure rate for symptom disappearance in study group 2 was 77.5%, with a total effective rate of 100%.

[0148] Example 3 Study Group: 40 patients with carotid artery stenosis were selected.

[0149] Diagnostic criteria for carotid artery plaques: Examination using color Doppler ultrasound, CT angiography (CTA), and digital subtraction angiography (DSA). Carotid intima-media thickness (IMT) is measured to determine the presence of atherosclerotic plaques. Currently, a normal IMT value is considered to be less than 1.0 mm; an IMT between 1.0 and 1.2 mm indicates intimal thickening; between 1.2 and 1.4 mm indicates plaque formation; and an IMT greater than 1.4 mm indicates carotid artery stenosis.

[0150] There are two commonly used methods for measuring carotid artery stenosis internationally: the North American Symptomatic Carotid Endarterectomy Trial Collaborators (NASCET) criteria and the European Carotid Surgery Trial Collaborators Group (ECST) criteria.

[0151] NASCET stenosis = (1 - width of blood flow at the narrowest point of the internal carotid artery / normal internal carotid artery diameter distal to the stenosis) × 100%

[0152] ECST stenosis = (1 - width of blood flow at the narrowest point of the internal carotid artery / simulated internal diameter at the dilation point of the internal carotid artery) × 100%

[0153] Both of the above methods classify the degree of internal carotid artery stenosis into four grades:

[0154] ① Mild stenosis, with the arterial diameter reduced by <30%;

[0155] ② Moderate stenosis, with the arterial diameter reduced by 30%–69%;

[0156] ③ Severe stenosis, with the arterial diameter reduced by 70%–99%;

[0157] ④ Complete occlusion.

[0158] Inclusion criteria for Case 3 in the study group of the example:

[0159] (1) Willing to accept traditional Chinese medicine external treatment;

[0160] (2) Carotid artery stenosis can be bilateral or unilateral;

[0161] (3) The intima-media thickness (IMT) of the carotid artery thrombotic plaque is between 2 and 12 mm, and the carotid artery stenosis is <60%;

[0162] (4) Whole-body CT scan, head CT scan confirmed no brain hemorrhage or low-density lesion images;

[0163] (5) Blood pressure <170 / 100 mmHg at the time of selection and assessment;

[0164] (6) No atrial fibrillation or severe T2 dysfunction;

[0165] (7) Diseases with no other obvious source of embolic emboli;

[0166] (8) No hemangioma was detected on whole-body CT scan.

[0167] Exclusion criteria for Case 3 in Study Group 3 of the Example:

[0168] (1) History of intracranial hemorrhage and tumor within the past six months;

[0169] (2) History of other bleeding disorders;

[0170] (3) Pregnant women;

[0171] (4) Poor blood glucose control in diabetic patients;

[0172] (5) Those whose blood pressure cannot be controlled effectively and in a timely manner or who experience significant fluctuations;

[0173] (6) Has a severe mental disorder;

[0174] (7) Severe liver and kidney dysfunction;

[0175] (8) Those who are averse to or allergic to the smell of Chinese medicine.

[0176] The study group consisted of 40 volunteers, including 25 males and 15 females, aged 35–65 years, with a mean age of (48.6±6.4) years. The treatment course for patients with carotid artery stenosis was 40 days: "Huabi Oil" solution was applied to the entire neck area morning, noon, evening, and before bedtime, at a dosage of 1–3 ml each time. Patients who had been taking oral medication previously could continue during the treatment period. High-fat and high-sugar foods were avoided; a light diet was recommended.

[0177] The efficacy evaluation criteria were based on a comparison of pre- and post-treatment examination results from a tertiary hospital. Clinical cure was defined as an IMT value <1.4mm and carotid artery stenosis <5%; effectiveness was defined as a decrease in IMT value and carotid artery stenosis compared to pre-treatment values; ineffectiveness was defined as no significant difference in the patient's imaging data and symptoms compared to pre-treatment levels.

[0178] No adverse reactions were recorded during the treatment with topical "Huabi Oil". There were no bleeding manifestations such as gingival bleeding, skin bleeding, oozing and ecchymosis, nor were there any other adverse reactions recorded.

[0179] The effectiveness of the treatment with "Huabi Oil" for 40 days, combined with patient feedback and CT imaging, is evaluated as shown in Table 3.

[0180] Table 3. Efficacy data of topical "Huabi Oil" treatment for 40 days in patients with carotid artery stenosis.

[0181] Experimental group Number of people IMT value <1.4mm, carotid artery stenosis <5% (number of people) The narrowness percentage has decreased compared to before (number of people). Clinical cure rate (%) Effectiveness (%) Inefficiency (%) Research Group 3 40 32 8 80 100 0

[0182] In the example study group 3, after 40 days of topical application of "Huabi Oil", the clinical cure rate of 40 patients with carotid artery stenosis was as high as 80%, and the clinical effectiveness rate was 100%.

[0183] Example 4 Study Group: 40 patients with leg and knee pain were selected.

[0184] Case inclusion criteria:

[0185] (1) Willing to accept traditional Chinese medicine external treatment;

[0186] (2) CT images showed no periosteal wear, no hyperplasia, and no replacement of the knee joint;

[0187] (3) The course of the disease is 0.5 to 1 year;

[0188] (4) Age 45 to 65 years old.

[0189] Exclusion criteria for cases:

[0190] (1) Individuals with poorly controlled blood glucose levels in diabetes;

[0191] (2) Pregnant women;

[0192] (3) No hemangioma was observed on whole-body CT scan;

[0193] (4) Has a severe mental disorder;

[0194] (5) Severe liver and kidney dysfunction;

[0195] (6) Those who are averse to or allergic to the smell of Chinese medicine.

[0196] There are many clinical treatments for external medications to treat leg and knee pain, such as acupuncture, plasters, and injections. The herbal essential oil solution of this invention, in addition to its effects of reducing swelling and relieving pain, has the medicinal power to directly penetrate and reach the ends of the meridians, nerves, and blood vessels in the leg and knee joints, thereby promoting the repair of cartilage cells to achieve the effect of treating and improving the patient's condition.

[0197] Evaluation of treatment effectiveness: Symptom disappearance indicates clinical cure, with the patient's leg and knee pain disappearing and returning to normal work and life; Effective indicates significant improvement in the patient's leg and knee pain and other symptoms, but discomfort still exists, with some improvement in the patient's leg and knee pain and other symptoms, allowing for partial resumption of work and life; Ineffective indicates that the patient's leg and knee pain and other symptoms are no different from before treatment.

[0198] The four patients in the study group were given the following medication: Apply "Huabi Oil" topically to the entire knee joint area three times a day, morning, noon, and night before bed, about 1-3 ml each time. The course of treatment was 30 days. Those who had been taking oral medication previously could continue this treatment. High-fat foods should be avoided; a light diet is recommended.

[0199] The effectiveness of the treatment, including 30 days of topical application of "Huabi Oil," patient feedback, and CT imaging, is evaluated as shown in Table 4.

[0200] Table 4. Efficacy data of external application of "Huabi Oil" for 20 days in patients with leg and knee pain.

[0201] Experimental group Number of people Symptoms disappeared (number of people) Symptoms lessened (number of people) Clinical cure rate with symptom disappearance (%) Effectiveness (%) Inefficiency (%) Research Group 4 40 38 2 95 100 0

[0202] In Example 4, after 30 days of topical application of "Huabi Oil", the clinical cure rate of 95% of the 40 patients with leg and knee pain was achieved, with an effectiveness rate of 100%.

[0203] As can be seen from the above examples, the herbal essential oil composition provided by the present invention has significant efficacy in treating diabetic retinopathy, cardiovascular and cerebrovascular diseases such as coronary heart disease, heart discomfort, pain, dull pain, angina, carotid artery sclerosis, plaque, venous artery thrombosis, or cervical, lumbar and leg joint pain. It is also convenient to use and can prevent and treat the diseases.

[0204] The embodiments of the present invention have been described in detail above, but the present invention is not limited to the described embodiments. Based on the above description of the present invention, and according to ordinary technical knowledge and common practice in the art, it will be obvious to those skilled in the art that various other changes and modifications can be made to these embodiments without departing from the TCM theory and pharmacology of the present invention, and these changes still fall within the protection scope of the present invention. Therefore, the present invention is not limited to the embodiments shown herein, but can be applied to a wider range consistent with the pharmacology and novel features of TCM prescriptions disclosed herein, which also still fall within the protection scope of the present invention.

Claims

1. A Chinese herbal medicine essential oil combination liquid for external use for diabetic eye disease and heart disease, characterized in that It is prepared from Chinese herbal medicine essential oil containing the following weight ratio: Arisaema 3-12 parts, Zanthoxylum 6-16 parts, Strychnos 5-18 parts, Aconitum 4-12 parts, Ephedra 2.5-9 parts, Hunteria 8-22 parts, Corydalis 9-19 parts, Pogostemon 9-17 parts, Chuanxiong 6-14 parts, Ginger 7-16 parts, Xichangqing 5-21 parts, Indigofera 7-25 parts, Angelica 7-21 parts, Monarda 5-19 parts, Cinnamon 4-16 parts, Mentha 2-8 parts, safflower 25-145 parts.

2. The topical herbal essential oil combination solution as described in claim 1, characterized in that... The Chinese herbal medicine essential oil combination liquid is prepared from essential oil containing the following raw medicinal materials: Arisaema, Zanthoxylum, Strychnos, Aconitum, Ephedra, Hunteria, Corydalis, Pogostemon, Chuanxiong, Ginger, Xichangqing, Indigofera, Angelica, Monarda, Cinnamon, Mentha, safflower.

3. The external use Chinese herbal essential oil combination liquid according to claims 1-2, characterized in that The Chinese herbal medicine essential oil combination liquid is specifically applied to external treatment of diabetic eye disease, heart disease, coronary heart disease, heart discomfort or pain, stuffy pain, angina, carotid arteriosclerosis, plaque, arteriovenous thrombosis, or cervical spondylosis, lumbar and leg joint pain disease and other related external medicines for swelling and pain relief, meridian and collateral relaxation, blood circulation and stasis.

4. The external use Chinese herbal medicine essential oil combination liquid according to claims 1-2, which comprises the essential oil of Chinese herbal medicine (also known as essential oil of Chinese medicine, essential oil of plant, essential oil of herb), and the preparation prepared by adding pharmaceutically acceptable excipients, and also includes the main components extracted from the essential oil of Chinese herbal medicine as claimed in claims 1-2, and the preparation prepared by adding pharmaceutically acceptable excipients.

5. The external use Chinese herbal essential oil combination liquid medicine according to claims 1-2, characterized in that It is prepared from raw medicinal materials, medicinal powder of raw medicinal materials, or concentrated extract of raw medicinal materials, or medicinal water extracted from raw medicinal materials, or oil, lotion, tincture extracted from raw medicinal materials by certain technology and process, or organic solvent extract of raw medicinal materials, and the preparation prepared by adding pharmaceutically acceptable excipients or auxiliary ingredients.

6. The external Chinese herbal essential oil combination liquid preparation according to claims 1 to 5, characterized by The preparation can be any drug way of preparation, or health product way of preparation, non-prescription product way of preparation, cosmetic product way of preparation, pure essential oil aromatherapy care product way of preparation.

7. The external Chinese herbal essential oil combination liquid preparation according to claims 1 to 6, characterized by The preparation can be any drug way of use, or health product way of use, non-prescription product way of use, cosmetic product way of use, pure essential oil aromatherapy care product way of use.

8. Use of the external use Chinese herbal medicine essential oil combination liquid preparation according to any one of claims 1-7 in the preparation of a medicine for preventing and / or treating diabetic eye disease.

9. Use of the external use Chinese herbal medicine essential oil combination liquid preparation according to any one of claims 1-7 in the preparation of a medicine for preventing and / or treating heart disease, coronary heart disease, heart discomfort or pain, stuffy pain, angina, heart failure in cardiovascular disease.

10. Use of the external use Chinese herbal medicine essential oil combination liquid preparation according to any one of claims 1-7 in the preparation of a medicine for preventing and / or treating carotid arteriosclerosis, middle cerebral artery stenosis, plaque, arteriovenous thrombosis, or cervical spondylosis, lumbar and leg joint pain disease and other related swelling and pain relief, meridian and collateral relaxation, blood circulation and stasis.