Fully human monoclonal antibody targeting rabies virus G protein epitope and application thereof

By developing a fully human monoclonal antibody targeting the G protein epitope of rabies virus, the high cost and safety issues of existing antibody preparations have been resolved, achieving a highly efficient and broad-spectrum rabies virus prevention effect.

CN121758604APending Publication Date: 2026-03-31WUHAN UNIV
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Patent Information

Application Number
CN202610237886.4
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-02-28
Publication Date
2026-03-31

AI Technical Summary

Technical Problem

Existing rabies virus monoclonal antibody preparations are expensive, have limited supply, and carry risks of serum infection and allergic reactions, and cannot effectively prevent rabies infection.

Method used

A fully human monoclonal antibody targeting the G protein epitope of rabies virus was developed. It was obtained by expressing and purifying the antibody using specific heavy and light chain variable region amino acid sequences through recombinant DNA technology. The antibody exhibits high affinity and broad-spectrum neutralizing activity.

Benefits of technology

The fully human monoclonal antibody showed highly effective neutralizing protection in rabies virus infection models, with broad-spectrum activity, stable half-life, and high safety, and can effectively prevent rabies virus infection.

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Abstract

The present invention provides a rabies virus G protein antigen epitope targeting completely human monoclonal antibody and applications thereof, the completely human monoclonal antibody comprises a heavy chain variable region and a light chain variable region, the heavy chain variable region has three complementary determining region amino acid sequences: GDISSSCFY, IHYSGST and ARHRRGYCYDSEKGGTNWFDP, and the light chain variable region has three complementary determining region amino acid sequences: GDISSSCFY, IHYSGST and ARHRRGYCYDSEKGGTNWFDP. The amino acid sequences of the three complementary determining regions of the light chain variable region are respectively as follows: QGISND, ATS and LQDYEFPLT. The fully human monoclonal antibody has efficient and broad-spectrum anti-rabies virus neutralizing activity, is high in expression, fully human-derived and good in stability, and can be used for preparing rabies virus detection products or drugs for preventing and treating rabies.
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