Preparation process of berberine hydrochloride

By using ferric sulfate-aluminum sulfate composite salt catalyst precursor and glyoxal aqueous solution treatment, combined with the use of sodium dodecyl sulfate, the problems of low purity and yield in berberine preparation were solved, achieving the preparation of high-purity, high-yield, and environmentally friendly berberine hydrochloride.

CN121930226BActive Publication Date: 2026-07-21WEIFANG HAIXIN PHARM CO LTD
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Patents(China)
Current Assignee / Owner
WEIFANG HAIXIN PHARM CO LTD
Filing Date
2026-03-31
Publication Date
2026-07-21

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Abstract

The application discloses a preparation process of berberine hydrochloride and belongs to the technical field of berberine production. The preparation process of the berberine hydrochloride comprises the following steps: S1, mixing iron sulfate-aluminum sulfate composite salt, sodium chloride, zinc chloride and anhydrous formic acid to pre-activate, adding N-2,3-dimethoxybenzyl piperidyl ethylamine hydrochloride, and dropwise adding a glyoxal mixed solution to perform reflux reaction; S2, cooling the reaction solution to precipitate solids, filtering, stirring the filter cake and diatomite in pure water, adjusting alkalinity, continuously stirring for 0.5-1 hours after temperature rising, cooling and filtering, and reserving the filtrate; S3, adjusting the filtrate to be acidic, cooling and crystallizing, filtering, rinsing the filter cake, vacuum drying the filter cake to obtain the berberine hydrochloride. The berberine hydrochloride prepared by the application has high yield and high purity, the preparation process is safe, the process is short, and the application is friendly to human bodies and the environment.
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Citation Information

Patent Citations

  • Synthetic process of berberine

    CN106543171A

  • Preparation of berberine and its salts

    CN1312250A

  • Green synthesis process of berberine

    CN108358912A