A porcine circovirus vaccine filling device

Abstract

This invention discloses a porcine circovirus vaccine filling device, relating to the field of vaccine filling technology. The device includes a filling assembly comprising a base, a support frame on top of the base, the support frame being L-shaped, a servo motor at the top of the support frame, and a connecting frame fixedly mounted on the bottom telescopic end of the servo motor through the support frame. The connecting frame has several sets of mounting holes arranged sequentially, through which connecting pipes are installed. This invention, by setting up the filling assembly, can effectively buffer the filling process. The sieve plate provides effective buffering and defoaming, solving the problem of air bubbles easily generated during filling in existing devices. It avoids the problem of large differences in drug dosage due to air bubbles, ensuring the product complies with veterinary pharmacopoeia regulations. Simultaneously, it prevents oxygen in the air bubbles from accelerating the oxidative denaturation of vaccine antigen proteins, ensuring the drug's efficacy and preventing immunization failure.

Description

Technical Field

[0001] This invention relates to the field of vaccine filling technology, and in particular to a porcine circovirus vaccine filling device. Background Technology

[0002] Porcine circovirus (PCV) is a single-stranded circular DNA virus belonging to the Circoviridae family. It is one of the smallest known animal viruses. Based on antigenicity and gene sequence differences, PCV is mainly divided into two genotypes: PCV-1 and PCV-2. PCV-1 is widespread in pig herds but is not pathogenic, while PCV-2 is the main pathogen causing porcine circovirus disease. Clinically, porcine circovirus disease mainly manifests as post-weaning multisystemic wasting syndrome. Infected piglets typically exhibit progressive emaciation, respiratory distress, swollen lymph nodes, and pale skin, with a high mortality rate. Furthermore, PCV-2 can also cause porcine dermatitis and nephrotic syndrome, leading to red papules on the skin and kidney failure in infected pigs. Infected sows may experience reproductive disorders, manifesting as abortion, stillbirth, or mummified fetuses. More seriously, PCV-2 has immunosuppressive properties; it attacks the pig's immune system, destroys immune cells, and leads to decreased immunity, making pigs susceptible to secondary infections with multiple pathogens such as porcine reproductive and respiratory syndrome virus (PRRSV), Haemophilus parasuis, and Streptococcus, resulting in complex mixed infections and causing huge economic losses to the pig industry. Currently, vaccination against porcine circovirus is the most effective means of controlling this disease. Porcine circovirus vaccines are mainly divided into inactivated vaccines and genetically engineered subunit vaccines, and their dosage forms usually include aqueous adjuvant vaccines and oil emulsion inactivated vaccines. In the vaccine production process, filling is a key process that determines the quality of the finished product and the level of aseptic assurance.

[0003] Existing porcine circovirus vaccine filling equipment is prone to generating air bubbles during the filling process. To enhance the immunization effect, porcine circovirus inactivated vaccines typically contain carbomer, aluminum hydroxide gel, or white oil adjuvants, which makes the vaccine liquid viscosity significantly higher than that of ordinary water-based injections. Traditional equipment has a straight-through outlet structure, and the liquid falls vertically to the bottom of the bottle during high-speed filling. Due to the high surface tension and high flow rate of the liquid, the droplets violently impact the bottom of the bottle, generating a large number of tiny air bubbles. These air bubbles can cause significant differences in the amount of medicine contained in the same batch of bottles, exceeding the range specified in the veterinary pharmacopoeia. They can also affect the accuracy of the immunization dosage. Furthermore, the oxygen in the air bubbles can accelerate the oxidative denaturation of vaccine antigen proteins, thereby reducing the immunogenicity of the vaccine and leading to immunization failure. Summary of the Invention

[0004] The purpose of this invention is to address the shortcomings of existing technologies by providing a porcine circovirus vaccine filling device.

[0005] To achieve the above objectives, the present invention adopts the following technical solution: A porcine circovirus vaccine filling device includes a filling assembly. The filling assembly includes a base, and a support frame is provided on the top of the base. The support frame is L-shaped, and a servo motor is provided at the top of the support frame. The telescopic end of the servo motor slides through the support frame and is fixedly installed with a connecting frame. The connecting frame has several sets of mounting holes arranged in sequence. A connecting pipe is installed through the mounting holes, and a filling valve is connected to the bottom of the connecting pipe. A filling head is detachably installed at the bottom of the filling valve. The filling head is hollow and conical. Several sets of sieve plates are detachably installed in the center of the filling head. The sieve plates are tightly fitted to the inner wall of the filling head. Several sets of guiding microholes are evenly opened on the surface of the sieve plates. The guiding microholes are arranged in concentric circles and are conical in shape with their tips pointing downwards. A conveying assembly for conveying is provided on one side of the base.

[0006] As a further embodiment of the present invention: the conveying assembly includes a mounting plate, which is mounted on the top of the base. A motor compartment is provided on one side of the mounting plate, and a drive shaft is connected to the output end of the motor compartment. One end of the drive shaft is rotatably disposed through the mounting plate. A pulley is provided on the drive shaft, and a conveyor belt is mounted on the pulley. The position of the conveyor belt is below the filling head. A correction component for correction is provided on one side of the mounting plate.

[0007] As a further embodiment of the present invention: the correction component includes a support plate, which is installed on the top of the mounting plate. A cylinder is provided on one side of the support plate. The telescopic end of the cylinder slides through the support plate and is fixedly installed on a mounting base. A drive motor is provided on the top of the mounting base. The output end of the drive motor is connected to several sets of connecting shafts. One end of the connecting shaft is rotatably installed through the mounting base. A conveyor wheel is provided on the connecting shaft. The conveyor wheel is arranged in a circle and has several sets of circular anti-slip grooves.

[0008] As a further embodiment of the present invention: a control panel is provided on the top of the base, and a protective film is affixed to one side of the control panel.

[0009] As a further embodiment of the present invention: several sets of protective frames are symmetrically arranged on the top of the mounting plate, and the protective frames are made of rubber.

[0010] As a further embodiment of the present invention: a fixed bracket is provided on one side of the filling valve, a cleaning ring is provided at one end of the fixed bracket, the position of the cleaning ring is adapted to the filling head, and a connector is provided on one side of the cleaning ring.

[0011] As a further embodiment of the present invention: a connecting flange is provided at the end of the connecting pipe, and a groove is provided on the top of the connecting flange, through which a gasket is provided.

[0012] As a further embodiment of the present invention: two sets of support wheels are rotatably mounted on one side of the mounting plate, and the size and position of the support wheels are adapted to the conveyor belt.

[0013] The beneficial effects of this invention are as follows: 1. By setting up the filling components, effective buffering can be achieved during filling. The sieve plate can effectively buffer and defoam, solving the problem of air bubbles easily generated during filling in existing devices. This avoids the problem of large differences in drug dosage caused by air bubbles, ensuring that the product complies with the regulations of the Veterinary Pharmacopoeia. At the same time, it can also prevent the oxygen in the air bubbles from accelerating the oxidation and denaturation of vaccine antigen proteins, ensuring its efficacy and avoiding the problem of immunization failure.

[0014] 2. By setting up a correction component, the filling bottles can be assisted in conveying. During the assisted conveying, the bottles can be prevented from shifting. At the same time, the shifted filling bottles can be corrected to prevent the porcine circovirus vaccine from spilling out due to the bottles shifting during filling.

[0015] 3. The cleaning ring generates suction to clean any residual porcine circovirus vaccine at the end of the filling head after filling, preventing contamination of other bottles due to residue at the filling head end. Attached Figure Description

[0016] Figure 1 This is a schematic diagram of the structure of a porcine circovirus vaccine filling device proposed in this invention from a frontal perspective; Figure 2 This is a schematic diagram of the filling section of a porcine circovirus vaccine filling device proposed in this invention; Figure 3 This is a schematic diagram of the conveying section of a porcine circovirus vaccine filling device proposed in this invention; Figure 4 This is a schematic diagram of the correction section of a porcine circovirus vaccine filling device proposed in this invention; Figure 5 This is a schematic diagram of the connection part of a porcine circovirus vaccine filling device proposed in this invention.

[0017] In the diagram: 1. Base; 2. Motor compartment; 3. Support plate; 4. Cylinder; 5. Control panel; 6. Mounting base; 7. Drive motor; 8. Filling head; 9. Filling valve; 10. Connecting frame; 11. Connecting pipe; 12. Servo motor; 13. Support frame; 14. Connecting flange; 15. Fixed bracket; 16. Cleaning ring; 17. Protective frame; 18. Conveyor belt; 19. Mounting plate; 20. Screen plate; 21. Connecting shaft; 22. Conveyor wheel; 23. Pulley; 24. Drive shaft; 25. Support wheel. Detailed Implementation

[0018] The technical solution of the present invention will be further described in detail below with reference to specific embodiments.

[0019] Embodiments of the present invention are described in detail below. Examples of these embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain the present invention, and should not be construed as limiting the present invention. Example 1

[0020] A porcine circovirus vaccine filling device, such as Figure 1-5 As shown, the system includes a filling assembly, which includes a base 1. A support frame 13 is provided on the top of the base 1. The support frame 13 is L-shaped. A servo motor 12 is provided at the top of the support frame 13. The telescopic end of the servo motor 12 slides through the support frame 13 and is fixedly installed with a connecting frame 10. The connecting frame 10 has several sets of mounting holes arranged in sequence. A connecting pipe 11 is installed through the mounting holes. A filling valve 9 is connected to the bottom of the connecting pipe 11. A filling head 8 is detachably installed at the bottom of the filling valve 9. The filling head 8 is hollow and conical. Several sets of sieve plates 20 are detachably installed in the center of the filling head 8. The sieve plates 20 are tightly fitted to the inner wall of the filling head 8. Several sets of flow guiding microholes are evenly opened on the surface of the sieve plates 20. The flow guiding microholes are arranged in concentric circles and are conical in shape with their tips pointing downwards. A conveying assembly for conveying is provided on one side of the base 1. In use, the conveying assembly transports the bottles to a position below the filling head 8. Once in place, the bottles align with several sets of filling heads 8. After alignment, the servo motor 12 activates the connecting frame 10, which in turn raises and lowers. Controlling the connecting frame 10's descent synchronously lowers the filling heads 8. After the filling head 8 descends, one end can be inserted into the bottle neck. The filling valve 9 opens, allowing for rapid filling of porcine circovirus vaccine. Before filling, the connecting pipe 11 can be connected to the feeding pipe. One end of the feeding pipe is connected to a conveying pump, which can quickly pump the porcine circovirus vaccine to be filled into several sets of connecting pipes 11 to complete the delivery, thus completing the feeding and facilitating the filling process. After the filling valve 9 is opened, the porcine circovirus vaccine in the connecting pipe 11 can enter the filling head 8 from the liquid outlet at the bottom of the filling valve 9. It can be quickly filled into the filling bottle through the filling head 8. The conical design of the filling head 8 makes it easy for its bottom end to be inserted into the filling bottle, which can avoid spillage during filling. Several sets of sieve plates 2 are set in the center of the filling head 8. The 0 provides an effective buffering and defoaming effect. When the porcine circovirus vaccine enters the filling head 8 under the pressure of a peristaltic pump or piston pump, the sieve plate 20, in conjunction with several sets of micro-channels, can achieve diversion and cutting effects. The large stream of liquid is first cut into fine liquid streams by the multiple micro-channels on the sieve plate 20. This changes the original turbulent state of the liquid and eliminates the air entrained in the large stream. Eliminating the entrained air prevents the generation of air bubbles during filling. The conical design of the micro-channels reduces the flow rate of the liquid. The reduced flow rate of the porcine circovirus vaccine further reduces the risk of air bubbles during filling. The vaccine solution flows slowly to the bottom of the bottle in a laminar flow state, which avoids the droplets directly impacting the bottom of the bottle and generating air bubbles. This solves the problem of air bubbles easily generated during the filling process of existing devices, and avoids the problem of large differences in the amount of medicine due to air bubbles. It can ensure that the product complies with the regulations of the Veterinary Pharmacopoeia. At the same time, it can also prevent the oxygen in the air bubbles from accelerating the oxidation and denaturation of the vaccine antigen protein, thus ensuring its efficacy and avoiding the problem of immunization failure. The sieve plate 20 is made of medical-grade polytetrafluoroethylene or 316L stainless steel, which can prevent the adhesion of bacteria from affecting the quality. The conveying assembly includes a mounting plate 19, which is mounted on the top of the base 1. A motor compartment 2 is provided on one side of the mounting plate 19. A drive shaft 24 is connected to the output end of the motor compartment 2. One end of the drive shaft 24 is rotatably installed through the mounting plate 19. A pulley 23 is provided on the drive shaft 24. A conveyor belt 18 is installed through the pulley 23. The position of the conveyor belt 18 is below the filling head 8. A correction assembly for correction is provided on one side of the mounting plate 19. In use, an industrial robot can place the filling bottles onto the conveyor belt 18. The motor in the motor compartment 2 can be started to control the rotation of the drive shaft 24 and the pulley 23. The rotation of the pulley 23 can drive the conveyor belt 18 to work. The conveyor belt 18 can continuously transport the filling bottles. Several groups of filling bottles can be transported to the bottom of the filling head 8 for filling. After filling, the bottles can be continuously transported. The industrial robot can collect the filled bottles for subsequent repackaging. After the filling bottles are transported to the bottom of the filling head 8, the conveyor belt 18 can be stopped. The filling process of porcine circovirus vaccine can be completed efficiently and conveniently. The correction assembly includes a support plate 3, which is installed on the top of the mounting plate 19. A cylinder 4 is provided on one side of the support plate 3. The telescopic end of the cylinder 4 slides through the support plate 3 and is fixedly installed on the mounting base 6. A drive motor 7 is provided on the top of the mounting base 6. The output end of the drive motor 7 is connected to several sets of connecting shafts 21. One end of the connecting shaft 21 is rotatably installed through the mounting base 6. A conveyor wheel 22 is provided on the connecting shaft 21. The conveyor wheel 22 is arranged in a circle and has several sets of circular anti-slip grooves. In use, the drive motor 7 starts and controls the rotation of the connecting shaft 21. The rotation of the connecting shaft 21 synchronously controls the rotation of the conveyor wheel 22. The conveyor wheel 22 is made of rubber, which can prevent damage to the filling bottle when in contact with it. At the same time, the circular anti-slip groove increases the friction when in contact with the filling bottle, thus preventing slippage. After the filling bottle is conveyed to the filling head 8 by the conveyor belt 18, the cylinder 4 starts and controls the mounting base 6 and the conveyor wheel 22 to move to one end. By adjusting the position of the two sets of mounting bases 6, the conveyor wheel 22 can be made to contact the two sides of the filling bottle respectively. After contact, the position of the filling bottle can be adjusted by controlling one end of the conveyor wheel 22. If the filling bottle deviates on the conveyor belt 18, it can be corrected by the conveyor wheel 22. By correcting the deviation, it can be accurately moved to the bottom of the filling head 8, which facilitates the filling process. The rotation of the conveyor wheel 22 can assist in the conveying of the filling bottle, which can prevent the deviation from occurring again during the conveying process. For ease of control, such as Figure 1 As shown, a control panel 5 is provided on the top of the base 1, and a protective film is affixed to one side of the control panel 5; In use, the control panel 5 is connected to the various components of the device via wires. The control panel 5 allows for convenient control of the start / stop and power of each component, facilitating easy adjustment as needed. To prevent the bottles from falling during transport, such as Figure 1 , 3 As shown, several sets of protective frames 17 are symmetrically arranged on the top of the mounting plate 19, and the protective frames 17 are made of rubber. During use, the protective frame 17 on the top of the mounting plate 19 can provide effective protection during transportation, preventing the filling bottles from accidentally falling during transportation. In order to collect the remaining vaccines, such as Figure 1 , 2 As shown, a fixed bracket 15 is provided on one side of the filling valve 9, and a cleaning ring 16 is provided at one end of the fixed bracket 15. The position of the cleaning ring 16 is adapted to the filling head 8, and a connector is provided on one side of the cleaning ring 16. During use, a negative pressure pump can be connected through the connector of the cleaning ring 16. The inner wall of the cleaning ring 16 has several sets of suction ports arranged in a circle. When the negative pressure pump is started, the cleaning ring 16 can generate suction. After filling, the suction generated by the suction port of the cleaning ring 16 can remove the residual porcine circovirus vaccine at the end of the filling head 8, thus completing the cleaning conveniently and avoiding the contamination of other filling bottles by the residue at the end of the filling head 8. To facilitate pipe connection, such as Figure 1 , 2 As shown in Figure 5, a connecting flange 14 is provided at the end of the connecting pipe 11. A groove is provided on the top of the connecting flange 14, and a gasket is provided through the groove. During use, the connection flange 14 can be used to reinforce the connection when connecting the pipe 11, which can prevent the connection from being accidentally broken and causing leakage of porcine circovirus vaccine. The gasket can increase the sealing of the connection and further prevent leakage. Example 2

[0021] To support the conveyor belt 18, refer to Figure 3 A porcine circovirus vaccine filling device, the present embodiment makes the following improvements compared with embodiment 1: two sets of support wheels 25 are rotatably installed on one side of the mounting plate 19, and the size and position of the support wheels 25 are adapted to the conveyor belt 18; During use, the rotatable support wheel 25 can support the conveyor belt 18, thereby preventing the problem of central collapse when conveying filling bottles and avoiding affecting normal conveying.

[0022] The above description is merely a preferred embodiment of the present invention. For parts that do not require creative effort in circuit control, signal control and transmission, please refer to the prior art. However, the scope of protection of the present invention is not limited thereto. Any equivalent substitutions or modifications made by those skilled in the art within the scope of the technology disclosed in the present invention, based on the technical solution and inventive concept of the present invention, should be covered within the scope of protection of the present invention.

Claims

1. A porcine circovirus vaccine filling device, characterized in that, The filling assembly includes a base (1), on which a support frame (13) is provided. The support frame (13) is L-shaped. A servo motor (12) is provided at the top of the support frame (13). The telescopic end of the servo motor (12) slides through the support frame (13) and is fixedly installed with a connecting frame (10). The connecting frame (10) has several sets of mounting holes arranged in sequence. A connecting pipe (11) is installed through the mounting holes. The bottom end of the connecting pipe (11) is connected to a... A filling valve (9) is provided. A filling head (8) is detachably installed at the bottom of the filling valve (9). The filling head (8) is shaped like a hollow cone. Several sets of sieve plates (20) are detachably installed in the center of the filling head (8). The sieve plates (20) are tightly fitted to the inner wall of the filling head (8). Several sets of flow guiding microholes are evenly opened on the surface of the sieve plates (20). The flow guiding microholes are arranged in concentric circles. The shape of the flow guiding microholes is conical with the cone tip pointing downwards. A conveying component for conveying is provided on one side of the base (1).

2. The porcine circovirus vaccine filling equipment according to claim 1, characterized in that, The conveying assembly includes a mounting plate (19), which is mounted on the top of the base (1). A motor compartment (2) is provided on one side of the mounting plate (19). A drive shaft (24) is connected to the output end of the motor compartment (2). One end of the drive shaft (24) is rotatably connected through the mounting plate (19). A pulley (23) is provided on the drive shaft (24). A conveyor belt (18) is installed through the pulley (23). The position of the conveyor belt (18) is below the filling head (8). A correction assembly for correction is provided on one side of the mounting plate (19).

3. The porcine circovirus vaccine filling equipment according to claim 2, characterized in that, The correction assembly includes a support plate (3), which is installed on the top of the mounting plate (19). A cylinder (4) is provided on one side of the support plate (3). The telescopic end of the cylinder (4) slides through the support plate (3) and is fixedly installed on the mounting base (6). A drive motor (7) is provided on the top of the mounting base (6). The output end of the drive motor (7) is connected to several sets of connecting shafts (21). One end of the connecting shaft (21) can rotatably pass through the mounting base (6). A conveyor wheel (22) is provided on the connecting shaft (21). The conveyor wheel (22) is arranged in a circle and has several sets of circular anti-slip grooves.

4. The porcine circovirus vaccine filling equipment according to claim 1, characterized in that, The base (1) is equipped with a control panel (5) on its top, and a protective film is affixed to one side of the control panel (5).

5. The porcine circovirus vaccine filling equipment according to claim 2, characterized in that, The mounting plate (19) has several sets of protective frames (17) symmetrically arranged on its top. The protective frames (17) are made of rubber.

6. The porcine circovirus vaccine filling equipment according to claim 1, characterized in that, A fixed bracket (15) is provided on one side of the filling valve (9), and a cleaning ring (16) is provided at one end of the fixed bracket (15). The position of the cleaning ring (16) is adapted to the filling head (8), and a connector is provided on one side of the cleaning ring (16).

7. The porcine circovirus vaccine filling equipment according to claim 1, characterized in that, A connecting flange (14) is provided at the end of the connecting pipe (11). A groove is provided on the top of the connecting flange (14), and a gasket is provided through the groove.

8. The porcine circovirus vaccine filling equipment according to claim 2, characterized in that, Two sets of support wheels (25) are rotatably mounted on one side of the mounting plate (19), and the size and position of the support wheels (25) are adapted to the conveyor belt (18).

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