Moisturizing care gel and method for its preparation

Abstract

This invention relates to the field of nursing gel technology, and discloses a moisturizing nursing gel and its preparation method. The nursing gel is prepared from deionized water, poloxamer 407 powder, β-glucan, an antibacterial composite particle dispersion, and an aqueous lactic acid solution. The antibacterial composite particle dispersion is prepared from chitosan, an aqueous acetic acid solution, an antibacterial moisturizer, a modified sodium alginate solution, and deionized water. The modified sodium alginate solution is prepared from an aqueous sodium alginate solution, an aqueous sodium hydroxide solution, dopamine hydrochloride, 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride, and deionized water. The antibacterial moisturizer is prepared from sodium hyaluronate, fructooligosaccharides, deionized water, polyhexamethylene biguanide hydrochloride, sodium pyrrolidone carboxylate, triethanolamine, sodium lactate, and an aqueous solution of 1,4-butanediol diglycidyl ether. This invention exhibits good antibacterial and moisturizing properties.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of care gels, in particular to a moisturizing care gel and a preparation method thereof. BACKGROUND

[0002] Female intimate care gels are a class of topical products used to maintain vaginal microecological balance, provide lubrication, and relieve dryness or discomfort. A healthy vaginal environment relies on a microecological system dominated by lactobacilli, which produce lactic acid through the metabolism of glycogen, maintaining a weakly acidic pH range of 3.8 to 4.5, thereby inhibiting excessive microbial growth.

[0003] The patent with publication number CN120241970A discloses a gynecological bacteriostatic care gel containing hydrolyzed collagen and a preparation method thereof, which comprises the following raw materials in parts by weight: hydrolyzed collagen 4-12 parts, glutathione 1-3 parts, sophoramine 2-4 parts, white resveratrol 0.2-0.5, hydroxybutyl chitosan 1-3 parts, traditional Chinese medicine extract 15-20 parts, sodium hyaluronate 0.5-1.5 parts, plant essential oil 0.1-0.25 parts, triethanolamine 1-3 parts, lactic acid 0.8-1.5 parts, carboxymethyl cellulose 1-2 parts, glycerol 1-1.5 parts, carbomer 1-2 parts, emulsifier 0.5-1.5 parts, pH adjuster 1-3 parts, irradiation improver 10-15 parts, and purified water to make up to 100 parts.

[0004] Existing gels mostly use water-based gel matrices such as carbomer and xanthan gum, and their moisturizing capacity mainly depends on moisturizing agents such as glycerol and hyaluronic acid in the formula. However, these moisturizing components are mostly in a free state and are easily lost under the action of body temperature or evaporation of body surface moisture, resulting in a short moisturizing duration of the product and affecting the sustainability of the product effect. SUMMARY

[0005] The present application aims to provide a moisturizing care gel and a preparation method thereof to solve the problems in the prior art.

[0006] To solve the above technical problems, the present application provides the following technical solutions: A moisturizing care gel, which is prepared from deionized water, poloxamer 407 powder, beta-glucan, bacteriostatic composite particle dispersion, and lactic acid aqueous solution; the bacteriostatic composite particle dispersion is prepared from chitosan, acetic acid aqueous solution, antibacterial moisturizing agent, modified sodium alginate solution, and deionized water; the modified sodium alginate solution is prepared from sodium alginate aqueous solution, sodium hydroxide aqueous solution, dopamine hydrochloride, 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride, and deionized water; and the antibacterial moisturizing agent is prepared from sodium hyaluronate, fructooligosaccharide, deionized water, polyhexamethylene biguanide hydrochloride, sodium pyrrolidone carboxylate, triethanolamine, sodium lactate, and 1,4-butanediol diglycidyl ether aqueous solution.

[0007] Furthermore, the number average molecular weight of sodium hyaluronate is 80,000-150,000 Da.

[0008] Furthermore, chitosan has a degree of deacetylation of 85-95% and a number-average molecular weight of 50,000-150,000 Da.

[0009] Furthermore, the mass fraction of the aqueous solution of 1,4-butanediol diglycidyl ether is 10-20%.

[0010] A method for preparing a moisturizing skincare gel includes the following steps: (1) Mix sodium hyaluronate, fructooligosaccharide and deionized water, and stir at 250-350 rpm for 2-4 hours. Then add polyhexamethylene biguanide hydrochloride, sodium pyrrolidone carboxylate, triethanolamine and sodium lactate, and continue stirring for 20-40 minutes. Under a water bath at 4-8℃ and a stirring speed of 700-900 rpm, add 1,4-butanediol diglycidyl ether aqueous solution dropwise over 30-60 minutes. After the addition is complete, continue stirring for 12-16 hours to obtain cross-linked hydrogel. Wash the cross-linked hydrogel with deionized water 2-4 times, and then use a homogenizer to break it up at 6000-8000 rpm for 50-70 seconds to obtain an antibacterial moisturizer. To facilitate the subsequent preparation and application of antibacterial composite particles, after obtaining the cross-linked hydrogel loaded with active ingredients, the hydrogel is pulverized into fine gel particles using a homogenizer to obtain an antibacterial moisturizer; these fine particles still retain some cross-linked structures and can slowly release the loaded ingredients in subsequent processes. (2) Under nitrogen protection, add sodium alginate aqueous solution to the reaction vessel, adjust the pH to 5.4-5.6 with sodium hydroxide aqueous solution of 9-11% by mass, then add dopamine hydrochloride and 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride, stir at 300-400 rpm for 5-7 hours under light-protected conditions and at room temperature, then place the mixture in a dialysis bag and dialyze with flowing deionized water for 44-52 hours to obtain modified sodium alginate, then redissolve it in deionized water to prepare a modified sodium alginate solution of 1-2% by mass; (3) Chitosan and acetic acid aqueous solution with a mass fraction of 1-2% are mixed at a mass ratio of 1:99-100 and stirred at a speed of 300-500 rpm for 4-6 hours to obtain a chitosan solution; then the antibacterial moisturizer and chitosan solution are mixed at a mass ratio of 1:1-1.5 and stirred at a speed of 180-220 rpm for 30-40 minutes, centrifuged at a speed of 8000-10000 rpm for 10-15 minutes to collect the precipitate, then the obtained precipitate is mixed with modified sodium alginate solution at a mass ratio of 1:1-1.5 and stirred at a speed of 180-220 rpm for 30-40 minutes, centrifuged at a speed of 8000-10000 rpm for 10-15 minutes to collect the precipitate, then the obtained precipitate is dispersed in deionized water to prepare an antibacterial composite particle dispersion with a mass fraction of 5-10%; (4) Mix deionized water, poloxamer 407 powder, β-glucan and antibacterial composite particle dispersion, stir at 180-220 rpm for 5.5-6.5 hours at 4-8℃, then stir at 5000-7000 rpm for 3-5 minutes, then adjust the pH to 4.1-4.3 with 9-11% lactic acid aqueous solution, and remove bubbles under vacuum of -0.085 to -0.095 MPa for 15-25 minutes to obtain nursing gel.

[0011] Furthermore, in step (1), the mass ratio of sodium hyaluronate, fructooligosaccharide, deionized water, polyhexamethylene biguanide hydrochloride, sodium pyrrolidone carboxylate, triethanolamine, sodium lactate, and 1,4-butanediol diglycidyl ether aqueous solution is 3.0-5.0:4.0-6.0:90-110:0.08-0.12:1.8-2.2:1-1.5:1.3-1.7:12-18.

[0012] Furthermore, in step (2), the mass ratio of sodium alginate aqueous solution, dopamine hydrochloride and 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride is 50:0.20-0.30:0.08-0.12.

[0013] Furthermore, in step (2), the mass fraction of the sodium alginate aqueous solution is 1-2%.

[0014] Furthermore, in step (2), the molecular weight cutoff of the dialysis bag is 3000-4000 Da.

[0015] Furthermore, in step (4), the mass ratio of deionized water, poloxamer 407 powder, β-glucan and antibacterial composite particle dispersion is 680-720:170-190:4.5-5.5:80-120.

[0016] Compared with the prior art, the beneficial effects achieved by the present invention are: 1. In this invention, the long-chain polysaccharide structure of sodium hyaluronate provides abundant hydroxyl groups. These hydroxyl groups undergo ring-opening etherification with the epoxy groups at both ends of the cross-linking agent 1,4-butanediol diglycidyl ether molecule to form a three-dimensional network, loading the active ingredient. Polyhexamethylene biguanide hydrochloride, as a physical antibacterial component, adsorbs and destroys the negatively charged microbial cell membrane through its positive charge. Fructooligosaccharides serve as prebiotics, while sodium pyrrolidone carboxylate and sodium lactate serve as natural moisturizing factors. Through the activation effect of carbodiimide hydrochloride, the carboxyl groups on the sodium alginate molecular chain undergo a condensation reaction with the amino groups in the dopamine hydrochloride molecule to form amide bonds, thereby obtaining modified sodium alginate. This graft retains the negative charge of the carboxyl groups of sodium alginate and the catechol structure of dopamine. The surface of the antibacterial moisturizer is negatively charged due to the presence of carboxyl groups of sodium hyaluronate. When it is combined with... When positively charged chitosan solutions are mixed, chitosan is uniformly coated onto the surface of the antibacterial moisturizer through electrostatic adsorption, forming the first outer shell and reversing the overall surface charge to positive. Subsequently, the positively charged composite particles are mixed with a negatively charged modified sodium alginate solution, and the second outer shell is adsorbed through electrostatic attraction, forming the final core-shell structure. This layer-by-layer self-assembly method can effectively control the shell thickness and structure. The catechol structure in this shell can enhance the adhesion to biological mucosa through interactions such as hydrogen bonding and π-π stacking under the application environment. Poloxamer 407 dissolves in water in a molecular state at low temperatures. During use, the polyoxypropylene segments dehydrate at body temperature, leading to micelle formation and tight stacking, ensuring the product's fluidity before application and its in-situ gelling properties after application. β-glucan locks in moisture through hydrogen bonding, improving water retention. Detailed Implementation

[0017] The following embodiments are provided to better understand the present invention and are not limited to the preferred embodiments described. They do not constitute a limitation on the content and scope of protection of the present invention. Any product that is the same as or similar to the present invention, derived by any person under the guidance of the present invention or by combining the features of the present invention with other prior art, falls within the protection scope of the present invention.

[0018] A moisturizing care gel, wherein the care gel is prepared from deionized water, poloxamer 407 powder, β-glucan, antibacterial composite particle dispersion, and lactic acid aqueous solution; the antibacterial composite particle dispersion is prepared from chitosan, acetic acid aqueous solution, antibacterial moisturizer, modified sodium alginate solution, and deionized water; the modified sodium alginate solution is prepared from sodium alginate aqueous solution, sodium hydroxide aqueous solution, dopamine hydrochloride, 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride, and deionized water; the antibacterial moisturizer is prepared from sodium hyaluronate, fructooligosaccharide, deionized water, polyhexamethylene biguanide hydrochloride, sodium pyrrolidone carboxylate, triethanolamine, sodium lactate, and 1,4-butanediol diglycidyl ether aqueous solution.

[0019] For experiments not specifically described in the examples, the procedures or conditions should be followed according to the conventional experimental procedures described in the literature in this field. Reagents or instruments whose manufacturers are not specified are all commercially available conventional reagent products.

[0020] Example 1

[0021] (1) Sodium hyaluronate, fructooligosaccharides, and deionized water were mixed and stirred at 250 rpm for 2 hours. Then, polyhexamethylene biguanide hydrochloride, sodium pyrrolidone carboxylate, triethanolamine, and sodium lactate were added, and stirring was continued for 20 minutes. Under a 4°C water bath and a stirring speed of 700 rpm, a 10% (w / w) aqueous solution of 1,4-butanediol diglycidyl ether was added dropwise over 30 minutes. After the addition was complete, stirring was continued for 12 hours to obtain a cross-linked hydrogel. The cross-linked hydrogel was washed twice with deionized water and then homogenized at 6000 rpm for 50 seconds to obtain an antibacterial moisturizing agent. The number average molecular weight of sodium hyaluronate was 80,000 Da. The mass ratio of sodium hyaluronate, fructooligosaccharides, deionized water, polyhexamethylene biguanide hydrochloride, sodium pyrrolidone carboxylate, triethanolamine, sodium lactate, and 1,4-butanediol diglycidyl ether aqueous solution is 3.0:4.0:90:0.08:1.8:1:1.3:12.

[0022] (2) Under nitrogen protection, a 1% sodium alginate aqueous solution was added to the reactor, and the pH was adjusted to 5.4 with a 9% sodium hydroxide aqueous solution. Then, dopamine hydrochloride and 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride were added. The mixture was stirred at 300 rpm for 5 hours under light-protected conditions and at room temperature. The mixture was then placed in a dialysis bag with a molecular weight cutoff of 3000 Da and dialyzed with flowing deionized water for 44 hours to obtain modified sodium alginate. The modified sodium alginate was then redissolved in deionized water to prepare a 1% modified sodium alginate solution. The degree of deacetylation of chitosan was 85%, and the number average molecular weight was 50000 Da. The mass ratio of sodium alginate aqueous solution, dopamine hydrochloride, and 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride was 50:0.20:0.08.

[0023] (3) Chitosan and acetic acid aqueous solution with a mass fraction of 1% were mixed at a mass ratio of 1:99 and stirred at 300 rpm for 4 hours to obtain a chitosan solution. Then, antibacterial moisturizer and chitosan solution were mixed at a mass ratio of 1:1 and stirred at 180 rpm for 30 minutes. The precipitate was collected by centrifugation at 8000 rpm for 10 minutes. The precipitate was then mixed with modified sodium alginate solution at a mass ratio of 1:1 and stirred at 180 rpm for 30 minutes. The precipitate was collected by centrifugation at 8000 rpm for 10 minutes. The precipitate was then dispersed in deionized water to prepare an antibacterial composite particle dispersion with a mass fraction of 5%.

[0024] (4) Deionized water, poloxamer 407 powder, β-glucan, and antibacterial composite particle dispersion were mixed and stirred at 180 rpm for 5.5 hours at 4°C, then stirred at 5000 rpm for 3 minutes. The pH was then adjusted to 4.1 using a 9% (w / w) lactic acid aqueous solution, and the mixture was degassed under a vacuum of -0.085 MPa for 15 minutes to obtain the nursing gel. The mass ratio of deionized water, poloxamer 407 powder, β-glucan, and antibacterial composite particle dispersion was 680:170:4.5:80.

[0025] Example 2

[0026] (1) Sodium hyaluronate, fructooligosaccharides, and deionized water were mixed and stirred at 300 rpm for 3 hours. Then, polyhexamethylene biguanide hydrochloride, sodium pyrrolidone carboxylate, triethanolamine, and sodium lactate were added, and stirring was continued for 30 minutes. Under a water bath at 6°C and a stirring speed of 800 rpm, a 15% (w / w) aqueous solution of 1,4-butanediol diglycidyl ether was added dropwise over 45 minutes. After the addition was complete, stirring was continued for 14 hours to obtain a cross-linked hydrogel. The cross-linked hydrogel was washed three times with deionized water and then homogenized at 7000 rpm for 60 seconds to obtain an antibacterial moisturizing agent. The number average molecular weight of sodium hyaluronate was 100,000 Da. The mass ratio of sodium hyaluronate, fructooligosaccharides, deionized water, polyhexamethylene biguanide hydrochloride, sodium pyrrolidone carboxylate, triethanolamine, sodium lactate, and 1,4-butanediol diglycidyl ether aqueous solution is 4.0:5.0:100:0.10:2.0:1.25:1.5:15.

[0027] (2) Under nitrogen protection, a 1.5% sodium alginate aqueous solution was added to the reactor. The pH was adjusted to 5.5 with a 10% sodium hydroxide aqueous solution. Then, dopamine hydrochloride and 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride were added. The mixture was stirred at 350 rpm for 6 hours at room temperature in the dark. The mixture was then placed in a dialysis bag with a molecular weight cutoff of 3500 Da and dialyzed with flowing deionized water for 48 hours to obtain modified sodium alginate. The modified sodium alginate was then redissolved in deionized water to prepare a 1.5% modified sodium alginate solution. The degree of deacetylation of chitosan was 90%, and the number average molecular weight was 100,000 Da. The mass ratio of sodium alginate aqueous solution, dopamine hydrochloride, and 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride was 50:0.25:0.10.

[0028] (3) Chitosan and acetic acid aqueous solution with a mass fraction of 1.5% were mixed at a mass ratio of 1:99.5 and stirred at 400 rpm for 5 hours to obtain a chitosan solution; then the antibacterial moisturizer and chitosan solution were mixed at a mass ratio of 1:1.25 and stirred at 200 rpm for 35 minutes. The precipitate was collected by centrifugation at 9000 rpm for 12 minutes. The precipitate was then mixed with modified sodium alginate solution at a mass ratio of 1:1.25 and stirred at 200 rpm for 35 minutes. The precipitate was collected by centrifugation at 9000 rpm for 12 minutes. The precipitate was then dispersed in deionized water to prepare an antibacterial composite particle dispersion with a mass fraction of 7.5%.

[0029] (4) Deionized water, poloxamer 407 powder, β-glucan, and antibacterial composite particle dispersion were mixed and stirred at 200 rpm for 6 hours at 6°C, then stirred at 6000 rpm for 4 minutes. The pH was then adjusted to 4.2 using a 10% (w / w) lactic acid aqueous solution, and degassing was performed under a vacuum of -0.090 MPa for 20 minutes to obtain the nursing gel. The mass ratio of deionized water, poloxamer 407 powder, β-glucan, and antibacterial composite particle dispersion was 700:180:5.0:100.

[0030] Example 3

[0031] (1) Sodium hyaluronate, fructooligosaccharides, and deionized water were mixed and stirred at 350 rpm for 4 hours. Then, polyhexamethylene biguanide hydrochloride, sodium pyrrolidone carboxylate, triethanolamine, and sodium lactate were added, and stirring was continued for 40 minutes. Under an 8°C water bath and a stirring speed of 900 rpm, a 20% (w / w) aqueous solution of 1,4-butanediol diglycidyl ether was added dropwise over 60 minutes. After the addition was complete, stirring was continued for 16 hours to obtain a cross-linked hydrogel. The cross-linked hydrogel was washed four times with deionized water and then homogenized at 8000 rpm for 70 seconds to obtain an antibacterial moisturizing agent. The number average molecular weight of sodium hyaluronate was 150,000 Da. The mass ratio of sodium hyaluronate, fructooligosaccharides, deionized water, polyhexamethylene biguanide hydrochloride, sodium pyrrolidone carboxylate, triethanolamine, sodium lactate, and 1,4-butanediol diglycidyl ether aqueous solution is 5.0:6.0:110:0.12:2.2:1.5:1.7:18.

[0032] (2) Under nitrogen protection, a 2% sodium alginate aqueous solution was added to the reactor. The pH was adjusted to 5.6 with an 11% sodium hydroxide aqueous solution. Then, dopamine hydrochloride and 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride were added. The mixture was stirred at 400 rpm for 7 hours under light-protected conditions and at room temperature. The mixture was then placed in a dialysis bag with a molecular weight cutoff of 4000 Da and dialyzed with flowing deionized water for 52 hours to obtain modified sodium alginate. The modified sodium alginate was then redissolved in deionized water to prepare a 2% modified sodium alginate solution. The degree of deacetylation of chitosan was 95%, and the number average molecular weight was 150,000 Da. The mass ratio of sodium alginate aqueous solution, dopamine hydrochloride, and 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride was 50:0.30:0.12.

[0033] (3) Chitosan and acetic acid aqueous solution with a mass fraction of 2% were mixed at a mass ratio of 1:100 and stirred at 500 rpm for 6 hours to obtain a chitosan solution; then the antibacterial moisturizer and chitosan solution were mixed at a mass ratio of 1:1.5 and stirred at 220 rpm for 40 minutes. The precipitate was collected by centrifugation at 10000 rpm for 15 minutes. The precipitate was then mixed with modified sodium alginate solution at a mass ratio of 1:1.5 and stirred at 220 rpm for 40 minutes. The precipitate was collected by centrifugation at 10000 rpm for 15 minutes. The precipitate was then dispersed in deionized water to prepare an antibacterial composite particle dispersion with a mass fraction of 10%.

[0034] (4) Deionized water, poloxamer 407 powder, β-glucan, and antibacterial composite particle dispersion were mixed and stirred at 220 rpm for 6.5 hours at 8°C, then stirred at 7000 rpm for 5 minutes. The pH was then adjusted to 4.3 using an 11% (w / w) lactic acid aqueous solution, and the mixture was degassed under a vacuum of -0.095 MPa for 25 minutes to obtain the nursing gel. The mass ratio of deionized water, poloxamer 407 powder, β-glucan, and antibacterial composite particle dispersion was 720:190:5.5:120.

[0035] Comparative Example 1 The only difference between Comparative Example 1 and Example 1 is that 1,4-butanediol diglycidyl ether aqueous solution was not added.

[0036] Comparative Example 2 The only difference between Comparative Example 2 and Example 1 is that the modified sodium alginate solution is omitted.

[0037] Comparative Example 3 The only difference between Comparative Example 3 and Example 1 is the omission of β-glucan.

[0038] The tests were conducted in accordance with the "Disinfection Technical Specifications" (2002 edition). The test strains were Staphylococcus aureus ATCC6538, Escherichia coli ATCC25922, and Candida albicans ATCC10231. The tests were repeated three times and the average value was calculated.

[0039] The sample was placed in an environment of 37℃ and 50% relative humidity for 4 hours, and then the moisture retention rate was calculated as (mass after placement / initial mass) × 100%. The average value was calculated by repeating the process 3 times.

[0040] Table 1 below shows the performance analysis results of the embodiments and comparative examples of the present invention.

[0041] Table 1

[0042] Experimental data from the examples and comparative examples show that the present invention uses sodium hyaluronate and 1,4-butanediol diglycidyl ether to construct a three-dimensional cross-linked network for physically loading polyhexamethylene biguanide hydrochloride, fructooligosaccharides, sodium pyrrolidone carboxylate, and sodium lactate. The surface of the antibacterial moisturizer is negatively charged due to the carboxyl groups of sodium hyaluronate. When mixed with a positively charged chitosan solution, chitosan is uniformly coated on the surface of the antibacterial moisturizer through electrostatic adsorption, forming a first outer shell and reversing the overall surface charge to positive. Subsequently, the positively charged composite particles... The particles are mixed with a negatively charged modified sodium alginate solution, and the second shell layer is adsorbed through electrostatic attraction to form the final core-shell structure. This layer-by-layer self-assembly method can effectively control the shell thickness and structure. The catechol structure in this shell can enhance the adhesion to biological mucosa through interactions such as hydrogen bonding and π-π stacking under the usage environment. Polyhexamethylene biguanide hydrochloride is used as an antibacterial agent to destroy the microbial cell membrane through electrostatic adsorption. β-glucan, as a hydrophilic natural polysaccharide, works synergistically with the natural moisturizing factors released by the antibacterial moisturizer to achieve multi-layer moisturization.

[0043] It will be apparent to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above, and that the invention can be implemented in other specific forms without departing from its spirit or essential characteristics. Therefore, the embodiments should be considered in all respects as exemplary and non-limiting, and the scope of the invention is defined by the appended claims rather than the foregoing description. Thus, all variations falling within the meaning and scope of equivalents of the claims are intended to be included within the present invention. No markings in the claims should be construed as limiting the scope of the claims.

Claims

1. A moisturizing skincare gel, characterized in that, The nursing gel is prepared from deionized water, poloxamer 407 powder, β-glucan, antibacterial composite particle dispersion, and lactic acid aqueous solution; the antibacterial composite particle dispersion is prepared from chitosan, acetic acid aqueous solution, antibacterial moisturizer, modified sodium alginate solution, and deionized water; the modified sodium alginate solution is prepared from sodium alginate aqueous solution, sodium hydroxide aqueous solution, dopamine hydrochloride, 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride, and deionized water; the antibacterial moisturizer is prepared from sodium hyaluronate, fructooligosaccharide, deionized water, polyhexamethylene biguanide hydrochloride, sodium pyrrolidone carboxylate, triethanolamine, sodium lactate, and 1,4-butanediol diglycidyl ether aqueous solution.

2. The moisturizing gel according to claim 1, characterized in that: Sodium hyaluronate has a number-average molecular weight of 80,000-150,000 Da.

3. The moisturizing gel according to claim 1, characterized in that: Chitosan has a degree of deacetylation of 85-95% and a number-average molecular weight of 50,000-150,000 Da.

4. The moisturizing care gel according to claim 1, characterized in that: The mass fraction of the aqueous solution of 1,4-butanediol diglycidyl ether is 10-20%.

5. A method for preparing a moisturizing skincare gel, applied to the moisturizing skincare gel according to any one of claims 1-4, characterized in that, Includes the following steps: (1) Mix sodium hyaluronate, fructooligosaccharide and deionized water, and stir at 250-350 rpm for 2-4 hours. Then add polyhexamethylene biguanide hydrochloride, sodium pyrrolidone carboxylate, triethanolamine and sodium lactate, and continue stirring for 20-40 minutes. Under a water bath at 4-8℃ and a stirring speed of 700-900 rpm, add 1,4-butanediol diglycidyl ether aqueous solution dropwise over 30-60 minutes. After the addition is complete, continue stirring for 12-16 hours to obtain cross-linked hydrogel. Wash the cross-linked hydrogel with deionized water 2-4 times, and then use a homogenizer to break it up at 6000-8000 rpm for 50-70 seconds to obtain an antibacterial moisturizer. (2) Under nitrogen protection, add sodium alginate aqueous solution to the reaction vessel, adjust the pH to 5.4-5.6 with sodium hydroxide aqueous solution of 9-11% by mass, then add dopamine hydrochloride and 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride, stir at 300-400 rpm for 5-7 hours under light-protected conditions and at room temperature, then place the mixture in a dialysis bag and dialyze with flowing deionized water for 44-52 hours to obtain modified sodium alginate, then redissolve it in deionized water to prepare a modified sodium alginate solution of 1-2% by mass; (3) Chitosan and acetic acid aqueous solution with a mass fraction of 1-2% are mixed at a mass ratio of 1:99-100 and stirred at a speed of 300-500 rpm for 4-6 hours to obtain a chitosan solution; then the antibacterial moisturizer and chitosan solution are mixed at a mass ratio of 1:1-1.5 and stirred at a speed of 180-220 rpm for 30-40 minutes, centrifuged at a speed of 8000-10000 rpm for 10-15 minutes to collect the precipitate, then the obtained precipitate is mixed with modified sodium alginate solution at a mass ratio of 1:1-1.5 and stirred at a speed of 180-220 rpm for 30-40 minutes, centrifuged at a speed of 8000-10000 rpm for 10-15 minutes to collect the precipitate, then the obtained precipitate is dispersed in deionized water to prepare an antibacterial composite particle dispersion with a mass fraction of 5-10%; (4) Mix deionized water, poloxamer 407 powder, β-glucan and antibacterial composite particle dispersion, stir at 180-220 rpm for 5.5-6.5 hours at 4-8℃, then stir at 5000-7000 rpm for 3-5 minutes, then adjust the pH to 4.1-4.3 with 9-11% lactic acid aqueous solution, and remove bubbles under vacuum of -0.085 to -0.095 MPa for 15-25 minutes to obtain nursing gel.

6. The method for preparing a moisturizing care gel according to claim 5, characterized in that: In step (1), the mass ratio of sodium hyaluronate, fructooligosaccharide, deionized water, polyhexamethylene biguanide hydrochloride, sodium pyrrolidone carboxylate, triethanolamine, sodium lactate, and 1,4-butanediol diglycidyl ether aqueous solution is 3.0-5.0:4.0-6.0:90-110:0.08-0.12:1.8-2.2:1-1.5:1.3-1.7:12-18.

7. The method for preparing a moisturizing care gel according to claim 5, characterized in that: In step (2), the mass ratio of sodium alginate aqueous solution, dopamine hydrochloride and 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride is 50:0.20-0.30:0.08-0.

12.

8. The method for preparing a moisturizing care gel according to claim 5, characterized in that: In step (2), the mass fraction of sodium alginate aqueous solution is 1-2%.

9. The method for preparing a moisturizing care gel according to claim 5, characterized in that: In step (2), the molecular weight cutoff of the dialysis bag is 3000-4000 Da.

10. The method for preparing a moisturizing care gel according to claim 5, characterized in that: In step (4), the mass ratio of deionized water, poloxamer 407 powder, β-glucan and antibacterial composite particle dispersion is 680-720:170-190:4.5-5.5:80-120.

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