A compact protein purification apparatus

CN122230385APending Publication Date: 2026-06-19NANJING TECH MEMBRANE APPLICATION TECHNOLOGY RESEARCH INSTITUTE CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
NANJING TECH MEMBRANE APPLICATION TECHNOLOGY RESEARCH INSTITUTE CO LTD
Filing Date
2026-03-13
Publication Date
2026-06-19

AI Technical Summary

Technical Problem

Existing protein purification equipment is prone to collisions or friction when installing and removing collection tubes below the gravity chromatography column, and the feeding and filtration stages are easily affected by large particulate impurities, resulting in insufficient mixing.

Method used

A compact protein purification device was designed, which uses a moving mechanism to adjust the position of the collection tube, sets up a processing mechanism and a feeding component for filtration and mixing, and combines a rotating component for stirring to ensure that the distance between the collection tube and the gravity chromatography column is adjustable, the feeding and filtration stages are separated, and the mixing process is compact.

Benefits of technology

The problem of collision between the collection tube and the gravity chromatography column was solved, friction was reduced, the influence of large particulate impurities was avoided, the mixing efficiency and equipment compactness were improved, and the cleaning process was simplified.

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Abstract

This invention discloses a compact protein purification device, relating to the field of protein purification equipment technology. It includes a ring frame, a support column mounted below the ring frame, and a base connected to the support column; a moving mechanism mounted on the base, the moving mechanism including a third lifting rod mounted on the base, a rotating ring rotatably connected to the outside of the support column, and a disc connected to the rotating ring via an adjusting member. The third lifting rod drives the rotating ring, the adjusting member, and the disc to move vertically. It also includes a mixing cylinder and a processing mechanism mounted on the ring frame; a second annular groove formed inside the ring frame; a support frame slidably connected to the support column; a receiving cylinder located below the mixing cylinder; and a gravity chromatography column connected to the receiving cylinder via a connecting pipe. This compact protein purification device, by incorporating the processing mechanism and the moving mechanism, achieves the goal of improving the efficiency of the equipment.
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Citation Information

Patent Citations

  • CN220056682U