A metal organic framework / calcium peroxide heterojunction composite nanomaterial, a preparation method and application thereof

By preparing metal-organic framework/calcium peroxide heterojunction composite nanomaterials, and constructing Janus heterojunctions using vanadium-doped CoTCPP and CaO2 nanoparticles, multifunctional regulation of diabetic periodontitis was achieved, improving microwave response efficiency and biocompatibility, and solving the problems of single function and ROS regulation imbalance in existing MOF materials.

CN122251633APending Publication Date: 2026-06-23SHANXI PROVINCIAL PEOPLES HOSPITAL (AFFILIATED HOSPITAL OF SHANXI HEALTH VOCATIONAL COLLEGE)
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANXI PROVINCIAL PEOPLES HOSPITAL (AFFILIATED HOSPITAL OF SHANXI HEALTH VOCATIONAL COLLEGE)
Filing Date
2026-05-22
Publication Date
2026-06-23

AI Technical Summary

Technical Problem

Existing metal-organic framework (MOF) materials for diabetic periodontitis have limited functionality and cannot achieve sequential and synergistic regulation of infection control, oxidative stress relief, immune regulation, and bone regeneration. They also suffer from ROS regulation imbalance, difficulty in balancing microwave response efficiency and biosafety, and weak interfacial bonding in heterojunction materials, leading to functional failure.

Method used

By preparing metal-organic framework/calcium peroxide heterojunction composite nanomaterials, using vanadium (V)-doped CoTCPP complexes and calcium peroxide (CaO2) nanoparticles to construct Janus heterojunction structures, microwave triggering was used to achieve microwave thermotherapy-dynamic synergistic sterilization, regulation of local glucose metabolism and promotion of bone tissue repair.

Benefits of technology

It achieves temporal and synergistic regulation of the pathological microenvironment of diabetic periodontitis, improves microwave energy absorption efficiency, and possesses highly efficient antibacterial, bidirectional ROS regulation, immune regulation and osteopromoting functions, solving the problems of single function and weak microwave response activity of traditional MOFs materials.

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Abstract

This invention discloses a metal-organic framework / calcium peroxide heterojunction composite nanomaterial, its preparation method, and its application. Vanadium (V) is doped into a CoTCPP complex formed by the coordination of tetrakis(4-carboxyphenyl)porphyrin (TCPP) and cobalt (Co) ions via a one-step coordination self-assembly method to construct a V-CoTCPP metal-organic framework matrix. The osteogenic and hypoglycemic functions of V endow the material with additional bioactivity. Based on this, calcium peroxide nanoparticles are loaded onto the V-CoTCPP surface via in-situ precipitation to form an inorganic-organic Janus heterojunction nanoplatform with an asymmetric structure. Under microwave triggering, this platform achieves synergistic functions of microwave thermotherapy-dynamic sterilization, regulation of local glucose metabolism, and promotion of bone tissue repair.
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