Whole body vascular intervention shunt stent multi-dimensional bionic test device

Abstract

This invention relates to the field of medical device technology and discloses a multi-dimensional biomimetic experimental device for whole-body vascular interventional shunt stents, comprising a mobile platform and a multi-dimensional detection matrix: a stent plate is fixedly connected to one side of the mobile platform, a stent rod is fixedly connected to the outside of the stent plate, a main trunk segment is provided inside the stent rod, and multiple lateral trunk segments are provided outside the main trunk segment; a reservoir, a peristaltic pump, and a pressure control valve are fixedly connected to the outside of the stent plate; a disassembly component one is provided at one end of the main trunk segment, and a disassembly component two is provided at one end of each lateral trunk segment or branch segment; the multi-dimensional detection matrix includes a miniature pressure sensor, an ultrasonic Doppler blood flow velocity measurement module, and a particle image velocity measurement system. Through the main trunk segment, lateral trunk segment, and branch segment, combined with the rapid sealing and snapping of modular disassembly components one and two, high-precision biomimetic simulation of the vascular bed in different parts of the human body is achieved.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, specifically to a multi-dimensional biomimetic experimental device for whole-body vascular interventional shunt stents. Background Technology

[0002] In the field of medical device technology, vascular interventional shunt stents are core interventional devices for treating vascular diseases such as vascular stenosis, aneurysms, and vascular malformations. Preclinical hemodynamic performance verification is a crucial step in determining the safety and effectiveness of these products. To ensure that the stent can adapt to the complex vascular environment after implantation and achieve its intended functions such as trunk dilation, collateral flow restriction, and multi-branch shunt, it is necessary to use biomimetic testing devices to simulate the human vascular structure and blood flow characteristics, and to systematically evaluate the impact of the stent on blood flow. Therefore, high-performance biomimetic testing devices have become a core supporting tool for the research, optimization, and clinical translation of vascular interventional shunt stents.

[0003] Currently, existing vascular stent blood flow testing devices in the industry mainly adopt localized and singular vascular simulation design schemes. These devices typically use ordinary elastic materials to make single-specification vascular simulation segments, which can only perform simplified simulations of blood vessels in a specific location (such as local segments of the coronary artery or carotid artery). Their design focuses on replicating the diameter or basic shape of a single blood vessel, without considering the significant differences in elastic modulus, lumen diameter gradient, branching angle, and bending morphology among different vascular beds throughout the human body. At the same time, the vascular simulation segments of existing devices mostly adopt one-piece molding or simple threaded connection structures. The one-piece molding structure cannot flexibly adjust the vascular combination shape, and the simple threaded connection structure has poor sealing reliability and is cumbersome to disassemble and assemble, making it difficult to achieve rapid combination and precise docking of main trunk segments, lateral trunk segments, and branch segments. As a result, the device can only adapt to the testing needs of specific types of stents or single vascular scenarios, and cannot cover the complex structural characteristics of different vascular beds throughout the body.

[0004] However, in the process of realizing the technical solution of this application, the inventors of this application discovered that the above-mentioned technology has at least the following technical problems: the existing test device lacks a reliable rapid sealing connection structure, which results in insufficient accuracy and comprehensiveness in the biomimetic simulation of the whole-body vascular environment, and cannot provide test conditions that fit the real clinical application scenario for the whole-body vascular interventional shunt stent. Summary of the Invention

[0005] To address the shortcomings of existing technologies, this invention provides a multi-dimensional biomimetic testing device for whole-body vascular interventional shunt stents. This device solves the problem that existing testing devices lack a reliable and rapid sealing connection structure, resulting in insufficient accuracy and comprehensiveness in the biomimetic simulation of the whole-body vascular environment, and thus failing to provide testing conditions that closely match real clinical application scenarios for whole-body vascular interventional shunt stents.

[0006] To achieve the above objectives, the present invention provides the following technical solution: a multi-dimensional biomimetic experimental device for whole-body vascular interventional shunt stents, comprising a mobile platform and a multi-dimensional detection matrix: A support plate is fixedly connected to one side of the mobile platform, and a support rod is fixedly connected to the outside of the support plate. A main section is provided inside the support rod, and multiple side sections are provided outside the main section. Multiple branch sections are provided outside the side sections. Miniature pressure sensors are installed at the intersection of the main trunk, lateral trunk, and branch segments. These miniature pressure sensors are used to collect pressure change data under the action of biomimetic blood flow. The externally fixed connection of the support plate is a liquid storage tank, a peristaltic pump and a pressure control valve. The pressure control valve is connected to the inside of the support rod through a hose to establish a biomimetic blood flow environment in constant flow or constant pressure mode. One end of the main trunk is provided with a disassembly component one, and one end of the side trunk or branch section is provided with a disassembly component two. The disassembly component one and the disassembly component two are engaged to achieve modular combination and sealed connection of the biomimetic blood vessel channel. The multi-dimensional detection matrix includes a miniature pressure sensor, an ultrasonic Doppler blood flow velocity measurement module, and a particle image velocimetry system, which are used to simultaneously acquire parameters such as pressure changes, blood flow velocity distribution, flow field shear stress, and blood flow turbulence intensity.

[0007] Preferably, the disassembly assembly includes a mounting ring, which is internally fixedly connected to the outside of the main section. A limiting groove is formed inside the mounting ring, and a rubber ring is fixedly connected inside the mounting ring. A T-shaped block is fixedly connected to one side of the mounting ring.

[0008] Preferably, the second disassembly component includes a second mounting ring, the inside of which is fixedly connected to the outside of the side section. An inner ring is fixedly connected to one side of the second mounting ring, and a rubber ring is fixedly connected to one side of the inner ring. A rubber ring is fixedly connected to the inside of the second mounting ring. The inner ring and the rubber ring are installed inside the limiting groove through the second mounting ring. A fixing post is provided inside the second mounting ring.

[0009] Preferably, the T-shaped block has multiple rubber pads fixedly connected inside, and the T-shaped block has a slot inside.

[0010] Preferably, a second fixing column is fixedly connected to the bottom end of the first fixing column, a conical block is fixedly connected to the bottom end of the second fixing column, a spring is provided between the conical block and the second disassembly assembly, and a T-shaped groove is provided inside the second disassembly assembly.

[0011] Preferably, the T-shaped block is engaged with the outside of the conical block via a T-shaped groove.

[0012] The preferred method of using the multi-dimensional biomimetic experimental device for whole-body vascular interventional shunt stents includes the following steps: S1. Modularly combine and connect the main trunk segment, lateral trunk segment and branch segment by disassembling component one and disassembling component two to construct a layered biomimetic vascular channel for simulating different vascular bed structures throughout the body. S2. The interventional shunt stent is implanted into the preset position of the main trunk, lateral trunk, or branch segment, and the stent is implanted and fixed by the snap-fit ​​of disassembly component one and disassembly component two. S3. Adjust the spatial orientation of the bionic blood vessel channel by using the X-axis moving component, Y-axis moving component and Z-axis moving component on the mobile platform to simulate different blood vessel directions and stent implantation postures. S4. Start the peristaltic pump and adjust the flow and pressure parameters through the pressure control valve to establish a biomimetic blood flow environment in constant flow or constant pressure mode. S5. Under the action of biomimetic blood flow, pressure changes, blood flow velocity distribution, flow field shear stress and blood flow turbulence intensity parameters are collected synchronously through a multi-dimensional detection matrix. S6. Turn off the peristaltic pump, release the jamming between disassembly component one and disassembly component two, and replace with an interventional shunt bracket of different specifications or types.

[0013] Preferably, in S2, the T-shaped block and the T-shaped groove are engaged to form a sealed, coaxial and detachable connection structure for the bionic vascular channel under stent implantation state, so as to ensure the stability and repeatability of the experiment.

[0014] Preferably, in S4, the step of establishing a biomimetic blood flow environment includes: By adjusting the operating parameters of the peristaltic pump and the opening of the pressure control valve, biomimetic blood flow supply can be achieved in constant flow or constant pressure modes.

[0015] Preferably, in S5, the pressure changes, blood flow velocity distribution, flow field shear stress, and blood flow turbulence intensity parameters of the main trunk, lateral trunk, and branch segments before and after the interventional shunt stent implantation are compared and analyzed to evaluate the impact of the interventional shunt stent on the hemodynamic characteristics of different vascular beds throughout the body.

[0016] This invention provides a multi-dimensional biomimetic experimental device for whole-body vascular interventional shunt stents. It has the following beneficial effects: 1. This invention achieves high-precision biomimetic simulation of vascular beds in different parts of the human body by using main trunk segments, lateral trunk segments and branch segments, and replicating elastic modulus, lumen diameter gradient, branch angle and bending shape. Combined with the rapid sealing and snapping of modular disassembly component one and disassembly component two, it improves the simulation degree and reliability of the experiment.

[0017] 2. The present invention sets up a three-axis adjustment mechanism for the mobile platform, along with a peristaltic pump and a pressure control valve, which can precisely control the stent implantation depth, coaxiality, and radial fit, and flexibly reproduce various physiological and pathological blood flow environments such as arterial pulsation or venous steady state, ensuring accurate stent implantation posture and controllable blood flow parameters, thereby significantly improving the repeatability and operational efficiency of the experiment, and facilitating comparative verification of multiple specifications and types of stents.

[0018] 3. This invention deploys a multi-dimensional detection matrix, including a miniature pressure sensor, an ultrasonic Doppler blood flow velocity measurement module, and a particle image velocimetry system. It can simultaneously collect multiple key parameters such as pressure changes, blood flow velocity distribution, flow field shear stress, and turbulence intensity. This provides data support for comprehensively evaluating the combined impact of interventional shunt stents such as trunk expansion type, collateral flow restriction type, and multi-branch shunt type on hemodynamics, effectively assisting in stent research and development optimization and preclinical safety verification. Attached Figure Description

[0019] Figure 1 This is a three-dimensional structural diagram of the present invention; Figure 2 This is a schematic diagram of a partial structure of the main section of the present invention; Figure 3 This is a partial structural diagram of the disassembly assembly of the present invention; Figure 4 This is a partial structural diagram of the disassembly component two of the present invention; Figure 5 This is a partial structural diagram of the cone-shaped block of the present invention.

[0020] The components include: 1. Moving platform; 12. X-axis moving assembly; 13. Y-axis moving assembly; 14. Z-axis moving assembly; 2. Support plate; 3. Support rod; 4. Main section; 5. Side section; 6. Miniature pressure sensor; 7. Liquid storage tank; 8. Peristaltic pump; 9. Pressure control valve; 10. Disassembly assembly one; 101. Mounting ring one; 102. Limiting groove; 103. Rubber ring one; 104. T-block; 105. Rubber pad; 106. Slot; 11. Disassembly assembly two; 111. Mounting ring two; 112. Inner ring; 113. Rubber ring two; 114. Rubber ring three; 115. Fixing post one; 116. Fixing post two; 117. Conical block; 118. Spring; 119. T-slot. Detailed Implementation

[0021] The technical solution of the present invention will now be clearly and completely described with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0022] Example 1 Please see the appendix Figure 1 -Appendix Figure 3 This invention provides a multi-dimensional biomimetic experimental device for whole-body vascular interventional shunt stents, including a mobile platform 1 and a multi-dimensional detection matrix. The mobile platform 1 includes an X-axis mobile component 12, a Y-axis mobile component 13 and a Z-axis mobile component 14. A stent plate 2 is fixedly connected to one side of the Y-axis mobile component 13. A stent rod 3 is fixedly connected to the outside of the stent plate 2. A main trunk segment 4 is provided inside the stent rod 3. Multiple lateral trunk segments 5 are provided outside the main trunk segment 4. Multiple branch segments are provided outside the lateral trunk segments 5. Miniature pressure sensors 6 are installed at the intersection of the main trunk segment 4, the lateral trunk segment 5 and the branch segment. The miniature pressure sensors 6 are used to collect pressure change data under the action of biomimetic blood flow. The external fixed connection of the support plate 2 is a liquid storage tank 7, a peristaltic pump 8 and a pressure control valve 9. The pressure control valve 9 is connected to the inside of the support rod 3 through a hose to establish a biomimetic blood flow environment in constant flow or constant pressure mode. One end of the main trunk 4 is provided with a disassembly component 10, and one end of the lateral trunk 5 or branch section is provided with a disassembly component 21. The disassembly component 10 and the disassembly component 211 are engaged to achieve modular combination and sealed connection of the biomimetic blood vessel channel. The multi-dimensional detection matrix includes a miniature pressure sensor 6, an ultrasonic Doppler blood flow velocity measurement module, and a particle image velocimetry system, which are used to simultaneously acquire parameters such as pressure changes, blood flow velocity distribution, flow field shear stress, and blood flow turbulence intensity.

[0023] Specifically, the main trunk segment 4, the lateral trunk segment 5, and the branch segments are made of medical-grade elastic materials. By controlling the elastic modulus, lumen diameter gradient, branching angle, and bending shape, the anatomical structure characteristics of blood vessels in different parts of the human body are highly replicated. Disassembly components 10 and 11 work together to enable rapid connection and disassembly while ensuring the high-pressure sealing of the channel. This facilitates the replacement of different types or specifications of interventional shunt stents, greatly improving test efficiency and repeatability, and reducing operational complexity and contamination risks. The reservoir 7, peristaltic pump 8, and pressure control valve 9 together construct a dual-mode blood flow drive system, which can accurately switch between constant flow and constant pressure states and reproduce healthy or pathological blood flow environments by adjusting simulated blood parameters. The miniature pressure sensor 6 is arranged in key intersection areas and, combined with the ultrasonic Doppler blood flow velocity module and particle image velocity measurement system, forms a multi-dimensional detection matrix. It can synchronously acquire multiple hemodynamic parameters such as pressure, velocity, shear stress, and turbulence in real time. The miniature pressure sensor 6 is also set at the starting position of the main trunk 4 and the outlet of the lateral trunk 5 to monitor the pressure changes entering and leaving the biomimetic vascular channel in real time, thereby capturing hemodynamic characteristics more accurately.

[0024] In measuring vascular dilation, the device monitors pressure at different locations within the blood vessel using multi-point pressure sensors and calculates the degree of dilation using a fluid dynamics model. Furthermore, through real-time diameter measurement, volume assessment, and pressure change monitoring, this device can provide a detailed description of the blood vessel's state during dilation, thereby enabling a comprehensive evaluation of vascular function.

[0025] Please see the appendix Figure 3 -Appendix Figure 5 The disassembly component 10 includes a mounting ring 101, which is internally fixedly connected to the outside of the main section 4. A limiting groove 102 is formed inside the mounting ring 101. A rubber ring 103 is fixedly connected inside the mounting ring 101. A T-shaped block 104 is fixedly connected to one side of the mounting ring 101. Multiple rubber pads 105 are fixedly connected inside the T-shaped block 104. A slot 106 is formed inside the T-shaped block 104.

[0026] Specifically, the mounting ring 101 is fixedly sleeved on the outside of the main section 4 to ensure a stable connection. Its internal limiting groove 102 accommodates the inner ring 112 and rubber ring of the disassembly component 11, achieving axial positioning and preventing misalignment during connection, thus ensuring the coaxiality and overall rigidity of the biomimetic blood vessel channel. The rubber ring 103 is fixed inside the mounting ring 101, tightly fitting against the opposite rubber ring to form a reliable radial seal, preventing leakage of simulated blood under high pressure or pulsating blood flow conditions. The T-shaped block 104 is integrally mounted on one side of the mounting ring 101, and its surface has multiple rubber pads 105 that buffer and increase friction during the locking process. The internal slot 106 of the T-shaped block 104 engages with the disassembly component 11 to achieve axial locking.

[0027] Please see the appendix Figure 3 -Appendix Figure 5 The disassembly assembly 2 11 includes a mounting ring 2 111. The mounting ring 2 111 is internally fixedly connected to the outside of the side section 5. An inner ring 112 is fixedly connected to one side of the mounting ring 2 111. A rubber ring 3 114 is fixedly connected to one side of the inner ring 112. A rubber ring 2 113 is fixedly connected to the inside of the mounting ring 2 111. The inner ring 112 and the rubber ring 3 114 are installed inside the limiting groove 102 through the mounting ring 2 111. A fixing post 115 is provided inside the mounting ring 2 111. A fixing post 2 116 is fixedly connected to the bottom end of the fixing post 115. A conical block 117 is fixedly connected to the bottom end of the fixing post 2 116. A spring 118 is provided between the conical block 117 and the disassembly assembly 2 11. A T-shaped groove 119 is opened inside the disassembly assembly 2 11. The T-shaped block 104 is engaged with the outside of the conical block 117 through the T-shaped groove 119.

[0028] Specifically, the second mounting ring 111 is fixedly sleeved on the outside of the side trunk section 5, corresponding to the first mounting ring 101. The inner ring 112 on one side is inserted into the limiting groove 102 to achieve axial limiting and guidance, avoiding bending or misalignment of the blood vessel channel and affecting the uniformity of blood flow. The second rubber ring 113 and the third rubber ring 114 are respectively set on the inner side of the second mounting ring 111 and the end face of the inner ring 112, and are in multiple fits with the first rubber ring 103 of the disassembly component 10 to form a double-layer radial seal, thereby effectively preventing leakage. The T-shaped groove 119 is opened on the inner side of the second mounting ring 111 to guide and accommodate the T-shaped block 104 to slide in. When the T-shaped block 104 is pushed into the T-shaped groove 119 and squeezes the inclined surface of the conical block 117, the spring 118 is compressed and stored. As the T-shaped block 104 goes deeper, the conical block 117 will be locked into the slot 106 to achieve self-locking.

[0029] Example 2 The method of using the multi-dimensional biomimetic experimental device for whole-body vascular interventional shunt stents includes the following steps: S1. The main trunk segment 4, the lateral trunk segment 5 and the branch segment are modularly combined and connected by disassembly component one 10 and disassembly component two 11 to construct a layered biomimetic vascular channel for simulating different vascular bed structures throughout the body. S2. The interventional shunt stent is implanted into the preset position of the main trunk 4, the lateral trunk 5, or the branch segment, and the stent is implanted and fixed by the snap-fit ​​of disassembly component 10 and disassembly component 2 11. S3. Adjust the spatial orientation of the bionic blood vessel channel by means of the X-axis moving component 12, Y-axis moving component 13 and Z-axis moving component 14 on the mobile platform 1 to simulate different blood vessel directions and stent implantation postures. S4. Start the peristaltic pump 8 and adjust the flow and pressure parameters through the pressure control valve 9 to establish a biomimetic blood flow environment in constant flow mode or constant pressure mode. S5. Under the action of biomimetic blood flow, pressure changes, blood flow velocity distribution, flow field shear stress and blood flow turbulence intensity parameters are collected synchronously through a multi-dimensional detection matrix. S6. Turn off the peristaltic pump 8, release the jamming state between disassembly component 10 and disassembly component 2 11, replace with different specifications or types of interventional shunt stents, and repeat the above steps to complete the comparative test.

[0030] Specifically, the main trunk segment 4, the lateral trunk segment 5, and the branch segments are made of medical-grade elastic materials. By designing the elastic modulus, lumen diameter gradient, branch angle, and bending shape, the anatomical structure characteristics of different vascular beds throughout the human body are highly replicated. The segments are quickly and securely modularly combined through the snap-fit ​​connection of disassembly component 10 and disassembly component 21, forming a biomimetic vascular channel for specific vascular scenarios, which is convenient for the implantation of interventional shunt stents of different specifications and functions.

[0031] When it is necessary to engage disassembly component 10 and disassembly component 2 11, first align the mounting ring 2 111 with the mounting ring 101, and insert the inner ring 112 and rubber ring 3 114 into the limiting groove 102. At this time, the rubber ring 2 113 and rubber ring 3 114 are in contact and sealed. At this time, the T-shaped block 104 and the rubber pad 105 will enter the T-groove 119. One end of the T-shaped block 104 will press against the cut surface of the conical block 117. When the conical block 117 is pressed, it will drive the fixing post 115 and fixing post 2 116 to move upward and drive the spring 118 to compress. When the T-shaped block 104 is fully engaged in the T-groove 119, the spring 118 will drive the conical block 117 to reset, so that the conical block 117 is engaged in the groove 106, thus completing the fixation.

[0032] When disassembly is required, simply pull the fixing post 115 to remove the conical block 117 from the inside of the slot 106, and then pull out the mounting ring 111 and the mounting ring 101.

[0033] Secondly, after the interventional shunt stent is implanted into the preset position of the biomimetic vascular channel, the X-axis moving component 12, Y-axis moving component 13 and Z-axis moving component 14 of the moving platform 1 are used to make adjustments to ensure that the implantation depth, coaxiality and radial fit with the vascular wall of the stent are highly simulated to the real clinical scenario, and to avoid experimental deviations caused by installation errors.

[0034] Then, through a constant pressure and constant flow dual-mode blood supply system consisting of a peristaltic pump 8 and a pressure control valve 9, simulated blood is pumped into the biomimetic blood vessel channel; in constant flow mode, it simulates steady-state blood flow in veins or peripheral blood vessels, and in constant pressure mode, it simulates dynamic fluctuations in arterial systolic / diastolic pressure; at the same time, it adjusts rheological parameters such as simulated blood viscosity and hematocrit to reproduce blood flow characteristics under healthy or pathological conditions.

[0035] After the biomimetic blood flow stabilizes, the miniature pressure sensor 6, the ultrasonic Doppler blood flow velocity measurement module, and the particle image velocimetry (PIV) system work synchronously to collect in real time the pressure changes, blood flow velocity distribution, flow field shear stress, and blood flow turbulence intensity of the proximal trunk, stent implantation segment, distal collateral branch, branch opening, and blood flow confluence area.

[0036] After the experiment, the blood supply system is shut off, the connection between disassembly component 10 and disassembly component 2 is released, and different types or specifications of interventional shunt stents are quickly replaced. The implantation, adjustment, blood supply, and testing steps are repeated to achieve efficient comparative testing of multiple groups of stents in the same or different biomimetic vascular scenarios, ensuring high repeatability and data reliability.

[0037] Furthermore, in S2, the T-shaped block 104 and the T-shaped groove 119 are engaged to form a sealed, coaxial and detachable connection structure for the bionic vascular channel under stent implantation state, so as to ensure the stability and repeatability of the experiment. The feature is that, in S4, the biomimetic blood flow establishment step includes: By adjusting the operating parameters of the peristaltic pump 8 and the opening of the pressure control valve 9, biomimetic blood flow supply in constant flow mode or constant pressure mode can be achieved. In S5, the pressure changes, blood flow velocity distribution, flow field shear stress, and blood flow turbulence intensity parameters of the proximal, implantation area, and distal end of the main trunk 4, lateral trunk 5, and branch segments before and after interventional shunt stent implantation were compared and analyzed to evaluate the impact of interventional shunt stents on the hemodynamic characteristics of different vascular beds throughout the body.

[0038] Specifically, in the stent implantation state, the biomimetic vascular channel, through the snap-fit ​​engagement of disassembly component 10 and disassembly component 2 11, along with the radial sealing of multiple rubber rings and the axial limiting of the inner ring 112 and the limiting groove 102, forms a sealed, coaxial, and quickly detachable connection structure. This avoids pressure fluctuations or flow field distortions caused by loose connections or seal failures. In S4, by adjusting the rotation speed and pulse frequency of the peristaltic pump 8 and the opening of the pressure control valve 9, flexible switching between constant flow mode and constant pressure mode is achieved: in constant flow mode, a stable flow rate is maintained to simulate steady-state blood flow in veins or peripheral blood vessels; in constant pressure mode, periodic pressure fluctuations are generated to reproduce the characteristics of arterial systolic and diastolic blood pressure. Simultaneously, combined with the adjustment of simulated blood viscosity and hematocrit in the reservoir 7, the rheological properties under healthy or various pathological conditions can be reproduced, enabling the established biomimetic blood flow environment to cover the physiological conditions of different vascular beds throughout the body, providing a reliable basis for subsequent stent performance evaluation.

[0039] In S5, a multi-dimensional detection matrix was used to systematically compare the interventional shunt stent before and after implantation: a miniature pressure sensor 6 collected pressure changes in the main trunk segment 4, the lateral trunk segment 5, and the proximal, implantation area, and distal end of the branch segments; an ultrasonic Doppler blood flow velocity measurement module acquired the blood flow velocity distribution; and a particle image velocimetry (PIV) system recorded the flow field shear stress and turbulence intensity. Through quantitative comparison of key parameters before and after implantation, the specific impact of the stent on hemodynamics in scenarios of main trunk expansion, lateral branch flow restriction, or multi-branch shunt was demonstrated.

[0040] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A multi-dimensional biomimetic experimental device for whole-body vascular interventional shunt stents, comprising a mobile platform (1) and a multi-dimensional detection matrix, characterized in that: The mobile platform (1) includes: an X-axis moving component (12), a Y-axis moving component (13) and a Z-axis moving component (14). A support plate (2) is fixedly connected to one side of the Y-axis moving component (13). A support rod (3) is fixedly connected to the outside of the support plate (2). A main section (4) is provided inside the support rod (3). Multiple side sections (5) are provided outside the main section (4). Multiple branch sections are provided outside the side sections (5). The intersection area of ​​the main trunk segment (4), the lateral trunk segment (5) and the branch segment is provided with a miniature pressure sensor (6), which is used to collect pressure change data under the action of biomimetic blood flow. The externally fixed connection of the support plate (2) is a liquid storage tank (7), a peristaltic pump (8) and a pressure control valve (9). The pressure control valve (9) is connected to the inside of the support rod (3) through a hose to establish a biomimetic blood flow environment in constant flow or constant pressure mode. One end of the main trunk section (4) is provided with a disassembly component one (10), and one end of the side trunk section (5) or branch section is provided with a disassembly component two (11). The disassembly component one (10) and the disassembly component two (11) are engaged to achieve modular combination and sealed connection of the bionic blood vessel channel. The multi-dimensional detection matrix includes a miniature pressure sensor (6), an ultrasonic Doppler blood flow velocity measurement module, and a particle image velocity measurement system, which are used to simultaneously acquire pressure changes, blood flow velocity distribution, flow field shear stress, and blood flow turbulence intensity parameters.

2. The multi-dimensional biomimetic experimental device for whole-body vascular interventional shunt stents according to claim 1, characterized in that, The disassembly assembly 1 (10) includes a mounting ring 1 (101), which is fixedly connected to the outside of the main section (4). A limiting groove (102) is opened inside the mounting ring 1 (101). A rubber ring 1 (103) is fixedly connected inside the mounting ring 1 (101). A T-shaped block (104) is fixedly connected to one side of the mounting ring 1 (101).

3. The multi-dimensional biomimetic experimental device for whole-body vascular interventional shunt stents according to claim 1, characterized in that, The disassembly assembly 2 (11) includes a mounting ring 2 (111), which is fixedly connected to the outside of the side dry section (5). An inner ring (112) is fixedly connected to one side of the mounting ring 2 (111), and a rubber ring 3 (114) is fixedly connected to one side of the inner ring (112). A rubber ring 2 (113) is fixedly connected to the inside of the mounting ring 2 (111). The inner ring (112) and the rubber ring 3 (114) are installed inside the limiting groove (102) through the mounting ring 2 (111). A fixing post 1 (115) is provided inside the mounting ring 2 (111).

4. The multi-dimensional biomimetic experimental device for whole-body vascular interventional shunt stents according to claim 2, characterized in that, The T-shaped block (104) has multiple rubber pads (105) fixedly connected inside, and the T-shaped block (104) has a slot (106) inside.

5. The multi-dimensional biomimetic experimental device for whole-body vascular interventional shunt stents according to claim 3, characterized in that, The bottom end of the first fixing column (115) is fixedly connected to the second fixing column (116), and the bottom end of the second fixing column (116) is fixedly connected to the conical block (117). A spring (118) is provided between the conical block (117) and the second disassembly assembly (11). The second disassembly assembly (11) has a T-shaped groove (119) inside.

6. The multi-dimensional biomimetic experimental device for whole-body vascular interventional shunt stents according to claim 5, characterized in that, The T-shaped block (104) is engaged with the outside of the conical block (117) via the T-shaped groove (119).

7. The method of using a multi-dimensional biomimetic experimental device for whole-body vascular interventional shunt stents, characterized in that, The multi-dimensional biomimetic experimental device for whole-body vascular interventional shunt stents as described in any one of claims 1-6 includes the following steps: S1. The main trunk segment (4), lateral trunk segment (5) and branch segment are modularly combined and connected by disassembling component one (10) and disassembling component two (11) to construct a layered biomimetic vascular channel for simulating different vascular bed structures throughout the body. S2. The interventional shunt stent is implanted into the preset position of the main trunk (4), the lateral trunk (5) or the branch segment, and the stent is implanted and fixed by the snap-fit ​​of disassembly component one (10) and disassembly component two (11). S3. Adjust the spatial orientation of the bionic blood vessel channel by means of the X-axis moving component (12), Y-axis moving component (13) and Z-axis moving component (14) on the moving platform (1) to simulate different blood vessel directions and stent implantation postures. S4. Start the peristaltic pump (8) and adjust the flow and pressure parameters through the pressure control valve (9) to establish a biomimetic blood flow environment in constant flow mode or constant pressure mode; S5. Under the action of biomimetic blood flow, pressure changes, blood flow velocity distribution, flow field shear stress and blood flow turbulence intensity parameters are collected synchronously through a multi-dimensional detection matrix. S6. Turn off the peristaltic pump (8), release the jamming state between disassembly component one (10) and disassembly component two (11), and replace with an interventional shunt bracket of different specifications or types.

8. The method of using the multi-dimensional biomimetic experimental device for whole-body vascular interventional shunt stents according to claim 7, characterized in that, In S2, the T-shaped block (104) and the T-shaped groove (119) are engaged to form a sealed, coaxial and detachable connection structure for the bionic blood vessel channel under stent implantation state, so as to ensure the stability and repeatability of the experiment.

9. The method of using the multi-dimensional biomimetic experimental device for whole-body vascular interventional shunt stents according to claim 7, characterized in that, In S4, the step of establishing the biomimetic blood flow environment includes: By adjusting the operating parameters of the peristaltic pump (8) and the opening of the pressure control valve (9), biomimetic blood flow supply in constant flow mode or constant pressure mode can be achieved.

10. The method of using the multi-dimensional biomimetic experimental device for whole-body vascular interventional shunt stents according to claim 7, characterized in that, In S5, the pressure changes, blood flow velocity distribution, flow field shear stress and blood flow turbulence intensity parameters of the proximal, implantation area and distal of the main trunk (4), lateral trunk (5) and branch segments before and after the interventional shunt stent implantation were compared and analyzed to evaluate the impact of the interventional shunt stent on the hemodynamic characteristics of different vascular beds throughout the body.

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