A multi-effect skin care essence for improving skin function and its preparation method

Abstract

This invention relates to a multi-effect skincare essence for improving skin function and its preparation method. The invention supplements essential lipids and phospholipid precursors for the skin by adding linoleic acid and ethanolamine, strengthening the stratum corneum barrier and cell membrane structure integrity. It also adds serum albumin to address the poor water solubility and easy oxidation of linoleic acid and ethanolamine, improving the stability and skin affinity of the active ingredients. Simultaneously, it adds stable inorganic salts of essential trace elements such as selenium, silicon, tin, vanadium, manganese, and molybdenum to enhance the skin's anti-aging, repair, and firming abilities. Furthermore, it adds transferrin, which, on the one hand, blocks iron-mediated Fenton reactions and free radical generation, reducing photoaging and oxidative stress damage; on the other hand, transferrin prevents oxidative inactivation of linoleic acid, vitamins, selenium, tin, and other components under iron ion catalysis, reducing oxidative loss and protecting the formula's activity. Thus, it synergistically achieves effects such as barrier repair, anti-inflammatory soothing, anti-aging and firming, and brightening of skin tone.

Description

Technical Field

[0001] This invention belongs to the field of skincare technology and relates to a multi-effect skincare essence that improves skin function and its preparation method. Background Technology

[0002] Skincare serums are highly concentrated and effective skincare products. Their core purpose is to provide precise and deep skin solutions for specific skin problems. They use small molecule penetration technology to deliver active ingredients directly to the skin's base layer, solving deep skin problems that traditional lotions and creams cannot address.

[0003] The skin consists of three layers: the epidermis, the dermis, and the subcutaneous tissue. Human skin is the body's first natural barrier, protecting tissues and organs from pathogens, microorganisms, and physical or mechanical damage, and preventing the loss of water, electrolytes, and nutrients. Damage to the skin barrier affects the skin's own repair mechanisms. Nutrient loss disrupts the internal environment of skin cells, leading to decreased skin resistance. Multi-functional skincare serums can provide comprehensive nutrition to skin cells, activate them, enhance their repair capabilities, and help restore the skin to a healthy state.

[0004] In the vast field of skincare products, various types of serums have emerged on the market, but their effects are relatively singular, with most focusing on moisturizing, whitening, and anti-wrinkle effects. For example, patent CN118217211 A discloses a whitening skincare serum and its preparation method, patent CN202211093789 discloses a whitening serum and its preparation method, and patent CN201810731701 discloses a whitening skincare serum with synergistic whitening effects and its preparation method, all emphasizing the effects of whitening, fading spots, and brightening skin tone; patent CN114504530A discloses a skincare serum with moisturizing and soothing effects and its preparation method, mainly focusing on moisturizing and soothing the skin.

[0005] Therefore, how to improve a multi-functional skincare essence that can provide comprehensive nutrition to meet the diverse skincare needs of modern people, while also achieving effects such as barrier repair, anti-inflammatory soothing, anti-aging and firming, and brightening of skin tone at the cellular level, is a technical problem that needs to be solved in this field. Summary of the Invention

[0006] To address the aforementioned technical problems, this invention proposes a multi-effect skincare essence for improving skin function and its preparation method. This invention, through a comprehensive nutritional formula, precisely targets the deep layers of the skin, resulting in firmer, plumper skin and effectively resolving skin problems.

[0007] The objective of this invention can be achieved through the following methods: In a first aspect, the present invention provides a multi-effect skin care essence for improving skin function, comprising the following ingredients: basic amino acid skin care essence, vitamins, serum albumin, linoleic acid, ethanolamine, transferrin, sodium selenite, sodium metasilicate, stannous chloride, ammonium metavanadate, manganese sulfate, ammonium molybdate, and adenine.

[0008] As one embodiment of the present invention, the raw materials of the amino acid skincare essence include: glycine, L-alanine, L-arginine hydrochloride, L-asparagine-water, L-aspartic acid, L-cysteine ​​hydrochloride-water, L-cysteine ​​hydrochloride, L-glutamic acid, L-glutamine, L-histidine hydrochloride-water, L-isoleucine, L-leucine, L-lysine hydrochloride, L-methionine, L-phenylalanine, L-proline, L-serine, L-Threonine, L-Tryptophan, L-Tyrosine disodium salt, L-Valine, Biotin, Choline chloride, Hypoxanthine sodium salt, Linoleic acid, Lipoic acid, Putrescine, Sodium pyruvate, Thymidine, HEPES, Pyridoxine hydrochloride, Riboflavin, Thiamine hydrochloride, Vitamin B12, D-Calcium pantothenate, Folic acid, Inositol, Nicotinamide; the biotinylate includes: Pyridoxine hydrochloride, Riboflavin, Thiamine hydrochloride, Vitamin B12, D-Calcium pantothenate, Folic acid, Inositol, Nicotinamide.

[0009] Furthermore, the multi-effect skincare essence comprises the following raw materials in the following mass concentrations: glycine 15-25 mg / L, L-alanine 2-5 mg / L, L-arginine hydrochloride 120-180 mg / L, L-asparagine-water 5-10 mg / L, L-aspartic acid 5-10 mg / L, L-cysteine ​​hydrochloride-water 15-20 mg / L, L-cysteine ​​hydrochloride 30-40 mg / L, L-glutamic acid 5-10 mg / L, L-glutamine 250-450 mg / L, L-histidine hydrochloride-water 30-50 mg / L, L-isoleucine 40-60 mg / L, L-leucine 50-70 mg / L, L-lysine hydrochloride 80-100 mg / L, L-protein... L-Phenylalanine 10-30 mg / L, L-Phenylalanine 25-45 mg / L, L-Proline 10-30 mg / L, L-Serine 15-35 mg / L, L-Threonine 40-60 mg / L, L-Tryptophan 5-15 mg / L, L-Tyrosine disodium salt 45-65 mg / L, L-Valine 40-60 mg / L, Biotin 0.001-0.01 mg / L, Choline chloride 5-15 mg / L, Hypoxanthine sodium salt 1-3 mg / L, Linoleic acid 0.02-0.06 mg / L, Lipoic acid 0.05-0.15 mg / L, Putrescine 0.05-0.1 mg / L, Sodium pyruvate 45-65 mg / L, Thymidine 0.2-0.4 mg / L, HEPES 3000-4000 mg / L, pyridoxine hydrochloride 1-3 mg / L, riboflavin 0.1-0.3 mg / L, thiamine hydrochloride 1-3 mg / L, vitamin B12 0.5-1 mg / L, D-calcium pantothenate 1-3 mg / L, folic acid 1-3 mg / L, inositol 10-20 mg / L, nicotinamide 1-3 mg / L, serum albumin 500-34000 mg / L, linoleic acid 0.02-0.06 mg / L, ethanolamine 1.0-1.5 mg / L, transferrin 1.0-2.0 mg / L, sodium selenite 0.5-0.7 mg / L, sodium metasilicate 0.5-0.7 mg / L, stannous chloride 0.5-0.7 mg / L, ammonium metavanadate 0.5-0.7 mg / L, manganese sulfate 0.5-0.7 mg / L, ammonium molybdate 0.5-0.7 mg / L, adenine 5.0-7.0 mg / L.

[0010] Furthermore, the multi-effect skincare essence comprises the following ingredients in the indicated concentrations: glycine 18.75 mg / L, L-alanine 4.45 mg / L, L-arginine hydrochloride 147.5 mg / L, L-asparagine-water 7.5 mg / L, L-aspartic acid 6.65 mg / L, L-cysteine ​​hydrochloride-water 17.56 mg / L, L-cysteine ​​hydrochloride 31.29 mg / L, L-glutamic acid 7.35 mg / L, L-glutamine 365 mg / L, L-histidine hydrochloride-water 31.48 mg / L, L-isoleucine 54.47 mg / L, L-leucine 59.05 mg / L, and L-lysine hydrochloride 91.25 mg / L. / L, L-methionine 17.24mg / L, L-phenylalanine 34.48mg / L, L-proline 17.25mg / L, L-serine 26.25mg / L, L-threonine 53.45mg / L, L-tryptophan 9.02mg / L, L-tyrosine disodium salt 55.79mg / L, L-valine 52.85mg / L, biotin 0.0035mg / L, choline chloride 8.98mg / L, hypoxanthine sodium salt 2.39mg / L, linoleic acid 0.042mg / L, lipoic acid 0.105mg / L, putrescine 0.081mg / L, sodium pyruvate 55mg / L, thymidine 0.365mg / L, HEPES 3574.5 mg / L, pyridoxine hydrochloride 2.031 mg / L, riboflavin 0.219 mg / L, thiamine hydrochloride 2.17 mg / L, vitamin B12 0.68 mg / L, D-calcium pantothenate 2.24 mg / L, folic acid 2.65 mg / L, inositol 2.6 mg / L, nicotinamide 2.02 mg / L, serum albumin 9500 mg / L, linoleic acid 0.04 mg / L, ethanolamine 1.104 mg / L, transferrin 1.504 mg / L, sodium selenite 0.50476 mg / L, sodium metasilicate 0.5324 mg / L, stannous chloride 0.5040226 mg / L, ammonium metavanadate 0.504117 mg / L, manganese sulfate 0.5040302 mg / L, ammonium molybdate 0.504248 mg / L, adenine 5.6724 mg / L.

[0011] Secondly, the present invention provides a method for preparing the multi-effect skin care essence, comprising the following steps: adding the raw materials to sterilized purified water according to the proportion, and stirring evenly to obtain the essence.

[0012] As one embodiment of the present invention, the disinfection method includes high-temperature disinfection.

[0013] As one embodiment of the present invention, the sterilized purified water is cooled to 35-45°C.

[0014] Thirdly, the present invention provides an application of the aforementioned multi-effect skincare essence in the preparation of skincare products.

[0015] As one embodiment of the present invention, the skin care product is a skin care product with moisturizing, whitening, soothing, anti-wrinkle and skin texture improvement effects.

[0016] As one embodiment of the present invention, the dosage form of the skin care product includes one of the following: toner, serum, lotion, and cream.

[0017] Compared with the prior art, the present invention has the following beneficial effects: 1. This invention supplements essential lipids and phospholipid precursors for the skin by adding linoleic acid and ethanolamine, strengthening the integrity of the stratum corneum barrier and cell membrane structure. It also adds serum albumin to address the poor water solubility and easy oxidation of linoleic acid and ethanolamine, improving the stability and skin affinity of the active ingredients. Simultaneously, it adds stable inorganic salts of essential trace elements such as selenium, silicon, tin, vanadium, manganese, and molybdenum to enhance the skin's anti-aging, repair, and firming abilities. Furthermore, it adds transferrin, which can block iron-mediated Fenton reactions and free radical generation, reducing photoaging and oxidative stress damage. It also prevents linoleic acid, vitamins, selenium, tin, and other components from oxidative inactivation under iron ion catalysis, effectively reducing oxidative loss and protecting the formula's activity. Thus, it synergistically achieves effects such as barrier repair, anti-inflammatory soothing, anti-aging and firming, and brightening of skin tone.

[0018] 2. This invention provides a multi-functional skincare essence and its preparation method. The essence optimizes the ratio between various functional ingredients to make the effective ingredients compatible and synergistic, effectively mobilizing skin cell function, promoting product absorption, and awakening skin vitality. It has the effects of deep hydration, brightening skin tone, and firming skin. Detailed Implementation

[0019] The present invention will now be described in detail with reference to specific embodiments. The following examples are implemented under the premise of the technical solution of the present invention, providing detailed implementation methods and specific operating procedures, which will help those skilled in the art to further understand the present invention. It should be noted that the scope of protection of the present invention is not limited to the following embodiments; any adjustments and improvements made under the concept of the present invention are all within the scope of protection of the present invention.

[0020] Example 1 Basic formula of skincare serum Glycine 18.75 mg / L, L-alanine 4.45 mg / L, L-arginine hydrochloride 147.5 mg / L, L-asparagine-water 7.5 mg / L, L-aspartic acid 6.65 mg / L, L-cysteine ​​hydrochloride-water 17.56 mg / L, L-cysteine ​​hydrochloride 31.29 mg / L, L-glutamic acid 7.35 mg / L, L-glutamine 365 mg / L, L-histidine hydrochloride-water 31.48 mg / L, L-isoleucine 54.47 mg / L, L-leucine 59.05 mg / L, L-lysine hydrochloride 91.25 mg / L, L-methionine 17.24 mg / L g / L, L-phenylalanine 34.48 mg / L, L-proline 17.25 mg / L, L-serine 26.25 mg / L, L-threonine 53.45 mg / L, L-tryptophan 9.02 mg / L, L-tyrosine disodium salt 55.79 mg / L, L-valine 52.85 mg / L, biotin 0.0035 mg / L, choline chloride 8.98 mg / L, hypoxanthine sodium salt 2.39 mg / L, linoleic acid 0.042 mg / L, lipoic acid 0.105 mg / L, putrescine 0.081 mg / L, sodium pyruvate 55 mg / L, thymidine 0.365 mg / L, HEPES 3574.5 mg / L, pyridoxine hydrochloride 2.031 mg / L, riboflavin 0.219 mg / L, thiamine hydrochloride 2.17 mg / L, vitamin B12 0.68 mg / L, D-calcium pantothenate 2.24 mg / L, folic acid 2.65 mg / L, inositol 2.6 mg / L, nicotinamide 2.02 mg / L.

[0021] Disinfect the required purified water and let it cool to about 40°C. Add the ingredients of the basic formula to the disinfected purified water one by one according to the ratio, and stir well to obtain the skin care essence.

[0022] Example 2 The skincare essence of Example 1 was optimized by adding the following ingredients to the base of Example 1: serum albumin 9500 mg / L, linoleic acid 0.04 mg / L, ethanolamine 1.104 mg / L, transferrin 1.504 mg / L, sodium selenite 0.50476 mg / L, sodium metasilicate 0.5324 mg / L, stannous chloride 0.5040226 mg / L, ammonium metavanadate 0.504117 mg / L, manganese sulfate 0.5040302 mg / L, ammonium molybdate 0.504248 mg / L, and adenine 5.6724 mg / L, thus obtaining the skincare essence of this invention.

[0023] Test Case 1 Using the whitening skincare essence prepared in Example 2 as a test sample, 20 volunteers were invited to participate in the test. A closed patch test was conducted on human skin. 0.02 mL of the test sample was pipetted into a patch applicator, and then applied to the flexor side of the volunteer's forearm with hypoallergenic adhesive tape. The test sample was removed after 24 hours, and skin reactions were observed at 0.5 h, 24 h, and 48 h after removal. The results were recorded according to the skin reaction grading standards in the *Cosmetic Safety Technical Specifications* (2015 edition). Test results: All volunteers showed negative reactions to the essence of Example 2, with no adverse reactions, proving that the essence's raw material formulation of this invention is safe.

[0024] Test Case 2 Eighty female volunteers, aged 23-55, were invited and randomly divided into four groups of 20 each.

[0025] The testers used the same method to apply the skincare essences from Examples 1-2 to their faces. After cleansing, the product was applied evenly to the face and gently massaged until fully absorbed. It was applied twice daily, morning and evening, for a trial period of two weeks. No other skincare products were used during this period. Evaluation indicators included moisturizing, whitening, soothing, anti-wrinkle, and skin texture improvement effects. The final evaluation results were calculated using average values, as shown in Table 1. Testers used a 5-point scale, with 1-5 representing very poor, poor, average, good, and very good, respectively. Cellular experiments showed that the differences in moisturizing and whitening properties between the products in Examples 1 and 2 were consistent with Table 1.

[0026] Table 1

[0027] The results in Table 1 show that this product has good moisturizing effect, whitening and anti-wrinkle effects, and can soothe and improve skin texture.

[0028] Comparative Example 1 The raw materials and preparation method of the multi-effect skin care essence in this comparative example are basically the same as those in Example 2, except that serum albumin is omitted.

[0029] Comparative Example 2 The raw materials and preparation method of the multi-effect skin care essence in this comparative example are basically the same as those in Example 2, except that linoleic acid and ethanolamine are omitted.

[0030] Comparative Example 3 The raw materials and preparation method of the multi-effect skin care essence in this comparative example are basically the same as those in Example 2, except that transferrin is omitted.

[0031] Comparative Example 4 The raw materials and preparation method of the multi-effect skin care essence in this comparative example are basically the same as those in Example 2. The only difference is that sodium selenite, sodium metasilicate, stannous chloride, ammonium metavanadate, manganese sulfate, and ammonium molybdate are omitted.

[0032] Based on the results of cell experiments and comparisons before and after product use, it can be seen from Comparative Example 2 and Comparative Example 1 that the present invention uses serum albumin as a highly efficient lipid carrier, which can encapsulate and bind linoleic acid and ethanolamine. On the one hand, this enhances their water solubility and promotes efficient absorption by skin cells; on the other hand, it protects the active ingredients from oxidation and reduces the irritation of free fatty acids to the skin. Therefore, the moisturizing, whitening, soothing, anti-wrinkle, and skin texture improvement effects of Comparative Example 1 are inferior to those of Example 2. Comparative Example 2 and Comparative Example 2 also show that the present invention utilizes linoleic acid and ethanolamine to directly participate in membrane structure construction, act on skin cells, and regulate cellular physiological activities. Therefore, the moisturizing, whitening, soothing, anti-wrinkle, and skin texture improvement effects of Comparative Example 2 are inferior to those of Example 2. As can be seen, the combination of linoleic acid, ethanolamine and serum albumin used in this invention strengthens the integrity of the stratum corneum barrier and cell membrane structure by supplementing essential lipids and phospholipid precursors for the skin, thereby achieving effects such as barrier repair, anti-inflammatory soothing, anti-aging and firming, and brightening of skin tone; serum albumin can further enhance the stability and skin affinity of active ingredients, making it suitable for sensitive skin, aging skin and post-medical aesthetic repair scenarios.

[0033] Comparative Examples 2 and 3 show that the present invention utilizes transferrin as a key functional protein for regulating iron metabolism in skin tissue and cells. Iron is an essential cofactor for DNA synthesis (ribonucleotide reductase) and mitochondrial respiration (cytochromes, dehydrogenases), directly determining cell proliferation and energy metabolism efficiency. Transferrin can bind free Fe³⁺ with high affinity. + This invention blocks the Fenton reaction and free radical generation mediated by iron ions, reducing photoaging and oxidative stress damage at the source and inhibiting iron-dependent inflammatory responses. Simultaneously, linoleic acid, vitamins, peptides, selenium, tin, and other components are easily oxidized and inactivated under the catalysis of iron ions; transferrin can effectively reduce such oxidative losses and protect the activity of the formula. Overall, it can repair the skin barrier, reduce skin inflammation, brighten skin tone, and soothe sensitive redness. Therefore, the moisturizing, whitening, soothing, anti-wrinkle, and skin texture improvement effects of Comparative Example 3 are inferior to those of Example 2. Comparing Example 2 and Comparative Example 4, it can be seen that this invention, by adding stable inorganic salt forms of essential trace elements such as selenium, silicon, tin, vanadium, manganese, and molybdenum, serves as a core cofactor for various functional proteins and key enzymes in skin cells (for example, selenium is the active center of glutathione peroxidase). Its core functions are powerful antioxidant and free radical scavenging, while participating in the regulation of cell energy metabolism, promoting the synthesis of extracellular matrix and collagen production, and synergistically enhancing the skin's anti-aging, repair and firming abilities. Therefore, the moisturizing, whitening, soothing, anti-wrinkle and skin texture improvement effects of Comparative Example 4 are inferior to those of Example 1.

[0034] In summary, the above-mentioned ingredients not only work synergistically to enhance their efficacy, but also, on top of the basic nutritional system, achieve comprehensive functional enhancements such as membrane structure strengthening, antioxidant defense, energy supply, and formula stability, significantly improving the product's repair, anti-aging, firming, brightening, and soothing and stabilizing effects.

[0035] The specific embodiments of the present invention have been described above. It should be understood that the present invention is not limited to the specific embodiments described above, and those skilled in the art can make various modifications or variations within the scope of the claims, which do not affect the essence of the present invention.

Claims

1. A multi-effect skin care essence for improving skin function, characterized in that, It includes the following ingredients: basic amino acid skincare essence, vitamins, serum albumin, linoleic acid, ethanolamine, transferrin, sodium selenite, sodium metasilicate, stannous chloride, ammonium metavanadate, manganese sulfate, ammonium molybdate, and adenine.

2. The multi-effect skincare essence according to claim 1, characterized in that, The raw materials of the amino acid skincare essence include: glycine, L-alanine, L-arginine hydrochloride, L-asparagine-water, L-aspartic acid, L-cysteine ​​hydrochloride-water, L-cystine hydrochloride, L-glutamic acid, L-glutamine, L-histidine hydrochloride-water, L-isoleucine, L-leucine, L-lysine hydrochloride, L-methionine, L-phenylalanine, L-proline, L-serine, L-threonine, L-tryptophan, L-tyrosine disodium salt, L-valine, biotin, choline chloride, sodium hypoxanthine, linoleic acid, lipoic acid, putrescine, sodium pyruvate, thymidine, and HEPES; the vitamins include: pyridoxine hydrochloride, riboflavin, thiamine hydrochloride, vitamin B12, D-calcium pantothenate, folic acid, inositol, and niacinamide.

3. The multi-effect skincare essence according to claim 2, characterized in that, The multi-effect skincare essence comprises the following ingredients in the following concentrations: glycine 15-25 mg / L, L-alanine 2-5 mg / L, L-arginine hydrochloride 120-180 mg / L, L-asparagine-water 5-10 mg / L, L-aspartic acid 5-10 mg / L, L-cysteine ​​hydrochloride-water 15-20 mg / L, L-cysteine ​​hydrochloride 30-40 mg / L, L-glutamic acid 5-10 mg / L, L-glutamine 250-450 mg / L, L-histidine hydrochloride-water 30-50 mg / L, L-isoleucine 40-60 mg / L, L-leucine 50-70 mg / L, L-lysine hydrochloride 80-100 mg / L, L-methionine 1... 0-30 mg / L, L-phenylalanine 25-45 mg / L, L-proline 10-30 mg / L, L-serine 15-35 mg / L, L-threonine 40-60 mg / L, L-tryptophan 5-15 mg / L, L-tyrosine disodium salt 45-65 mg / L, L-valine 40-60 mg / L, biotin 0.001-0.01 mg / L, choline chloride 5-15 mg / L, hypoxanthine sodium salt 1-3 mg / L, linoleic acid 0.02-0.06 mg / L, lipoic acid 0.05-0.15 mg / L, putrescine 0.05-0.1 mg / L, sodium pyruvate 45-65 mg / L, thymidine 0.2-0.4 mg / L, HEPES 3000-4000 mg / L, pyridoxine hydrochloride 1-3 mg / L, riboflavin 0.1-0.3 mg / L, thiamine hydrochloride 1-3 mg / L, vitamin B12 0.5-1 mg / L, D-calcium pantothenate 1-3 mg / L, folic acid 1-3 mg / L, inositol 10-20 mg / L, nicotinamide 1-3 mg / L, serum albumin 500-34000 mg / L, linoleic acid 0.02-0.06 mg / L, ethanolamine 1.0-1.5 mg / L, transferrin 1.0-2.0 mg / L, sodium selenite 0.5-0.7 mg / L, sodium metasilicate 0.5-0.7 mg / L, stannous chloride 0.5-0.7 mg / L, ammonium metavanadate 0.5-0.7 mg / L, manganese sulfate 0.5-0.7 mg / L, ammonium molybdate 0.5-0.7 mg / L, adenine 5.0-7.0 mg / L.

4. The multi-effect skincare essence according to claim 3, characterized in that, The multi-effect skincare essence comprises the following ingredients in the following concentrations: glycine 18.75 mg / L, L-alanine 4.45 mg / L, L-arginine hydrochloride 147.5 mg / L, L-asparagine-water 7.5 mg / L, L-aspartic acid 6.65 mg / L, L-cysteine ​​hydrochloride-water 17.56 mg / L, L-cysteine ​​hydrochloride 31.29 mg / L, L-glutamic acid 7.35 mg / L, L-glutamine 365 mg / L, L-histidine hydrochloride-water 31.48 mg / L, L-isoleucine 54.47 mg / L, L-leucine 59.05 mg / L, and L-lysine hydrochloride 91.25 mg / L. L-Methionine 17.24 mg / L, L-Phenylalanine 34.48 mg / L, L-Proline 17.25 mg / L, L-Serine 26.25 mg / L, L-Threonine 53.45 mg / L, L-Tryptophan 9.02 mg / L, L-Tyrosine disodium salt 55.79 mg / L, L-Valine 52.85 mg / L, Biotin 0.0035 mg / L, Choline chloride 8.98 mg / L, Hypoxanthine sodium salt 2.39 mg / L, Linoleic acid 0.042 mg / L, Lipoic acid 0.105 mg / L, Putrescine 0.081 mg / L, Sodium pyruvate 55 mg / L, Thymidine 0.365 mg / L, HEPES 3574.5 mg / L, pyridoxine hydrochloride 2.031 mg / L, riboflavin 0.219 mg / L, thiamine hydrochloride 2.17 mg / L, vitamin B12 0.68 mg / L, D-calcium pantothenate 2.24 mg / L, folic acid 2.65 mg / L, inositol 2.6 mg / L, nicotinamide 2.02 mg / L, serum albumin 9500 mg / L, linoleic acid 0.04 mg / L, ethanolamine 1.104 mg / L, transferrin 1.504 mg / L, sodium selenite 0.50476 mg / L, sodium metasilicate 0.5324 mg / L, stannous chloride 0.5040226 mg / L, ammonium metavanadate 0.504117 mg / L, manganese sulfate 0.5040302 mg / L, ammonium molybdate 0.504248 mg / L, adenine 5.6724 mg / L.

5. A method for preparing a multi-effect skincare essence as described in any one of claims 1-4, characterized in that, The process includes the following steps: Add the raw materials to sterilized purified water according to the specified ratio, and stir until well mixed.

6. The preparation method according to claim 5, characterized in that, The disinfection methods include high-temperature disinfection.

7. The preparation method according to claim 5, characterized in that, The sterilized purified water is cooled to 35-45℃.

8. The use of a multi-effect skincare essence as described in any one of claims 1-4 in the preparation of skincare products.

9. The application according to claim 8, characterized in that, The skincare products mentioned are those with moisturizing, whitening, soothing, anti-wrinkle, and skin texture-improving effects.

10. The application according to claim 8, characterized in that, The dosage form of the skin care products includes one of the following: toner, serum, lotion, and cream.

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