A male mousse containing phmb and a preparation method thereof

Abstract

This invention belongs to the field of personal care product technology, specifically relating to a male genital mousse wash containing PHMB and its preparation method. The wash uses polyhexamethylene biguanide hydrochloride (PHMB) as the core antibacterial agent, combined with cocoylpropyl betaine and sodium lauroyl sarcosinate as the cleansing surfactant system, compounded with sodium hyaluronate, panthenol, and dipotassium glycyrrhizate, supplemented with propylene glycol, glycerin, disodium EDTA, and phenoxyethanol. The pH is adjusted to 5.0–6.0 with L-lactic acid, and the remainder is water for injection. The preparation employs a low-temperature stepwise feeding process to obtain a weakly acidic mousse foam. The product exhibits an antibacterial rate of ≥99.99% against Escherichia coli, Staphylococcus aureus, and Candida albicans, is non-irritating to the skin, produces a dense and stable foam that is easy to rinse, and has good high and low temperature stability. It combines cleansing, antibacterial, and mucosal repair effects, solving the problems of traditional feminine hygiene products such as high irritation, easy allergy, and poor dosage form experience. It is suitable for daily cleaning and care of the male genitalia.

Description

Technical Field

[0001] This invention belongs to the field of personal care product technology, specifically relating to a men's mousse wash containing PHMB and its preparation method. Background Technology

[0002] The information disclosed in this background section is intended only to enhance understanding of the overall background of the invention and is not necessarily to be construed as an admission or in any way implying that such information constitutes prior art known to those skilled in the art.

[0003] The male genital skin and mucous membranes have a unique environment and are easily contaminated by clothing, sweat, urine, etc., becoming a breeding ground for bacteria and fungi. Conventional care products have the following technical challenges: 1. Irritation and barrier damage: Traditional strong alkaline washes or high-concentration alcohol products, although they have a bactericidal effect, will destroy the local weak acid environment, leading to dryness and sensitivity of the mucous membrane.

[0004] 2. Ingredient safety: Some products use ingredients such as chlorhexidine, which may pose a risk of sensitization or drug resistance with long-term use.

[0005] 3. Poor product formulation experience: Liquid cleansers are too fluid and difficult to adhere to the skin for a long time, resulting in incomplete cleaning; ointment products are difficult to rinse off and are prone to leaving residue.

[0006] Polyhexamethylene guanidine hydrochloride (PHMB), as a cationic broad-spectrum bactericide, has advantages such as broad bactericidal spectrum, non-sensitizing properties, and no drug resistance after long-term use, and has been widely used in ophthalmology, wound care, and other fields. However, how to stably compound it into gentle cleansing systems and adapt it to the physiological characteristics of male genital areas is a technical challenge that the industry urgently needs to solve. Summary of the Invention

[0007] To address the aforementioned shortcomings, this invention provides a novel, mildly acidic, mousse-textured, gentle yet highly effective skin care wash. This mousse wash, when pumped out, produces a gentle, fine foam that is non-irritating to the skin when applied to the target area and exhibits excellent antibacterial effects.

[0008] Based on the above-mentioned technical effects, the present invention provides the following technical solution: In a first aspect, a male enhancement mousse wash containing PHMB is provided, wherein the raw materials of the mousse wash include at least the following components: 1) Core antibacterial agent: PHMB; 2) Cleaning system: Cocoylpropyl Betaine, Sodium Lauroyl Sarcosinate; 3) Moisturizing complex: Sodium hyaluronate, panthenol, dipotassium glycyrrhizate; 4) Additives: Propylene glycol, glycerin, disodium EDTA.

[0009] PHMB is a medical-grade broad-spectrum antibacterial agent commonly used in medical settings such as wound care, ophthalmology, feminine hygiene, and medical disinfection. While PHMB has excellent bactericidal effects, it is a strong cationic bactericide and is insoluble in anionic surfactants, which are the main surfactants used in existing personal care products, making stable coexistence impossible. Furthermore, PHMB has poor foaming properties, is not resistant to high temperatures or strong shear, and must be added at low temperatures and stirred at low speeds.

[0010] To provide a foaming cleaning product using PHMB as the core antibacterial agent, this invention incorporates cocoylpropyl betaine (CAB) and sodium lauroyl sarcosinate as core foaming and stabilizing ingredients. Additionally, propylene glycol, glycerin, and sodium hyaluronate are introduced to increase the viscosity of the product, resulting in a denser and more elastic foam. Furthermore, this invention has found that dipotassium glycyrrhizate and panthenol effectively enhance the antibacterial effect of PHMB and the foaming effect of the mousse foam. Dipotassium glycyrrhizate also helps maintain the high-temperature stability of this cleaning product.

[0011] In addition, the above-mentioned mousse wash also includes other excipients, such as pH adjusters and preservatives; feasible pH adjusters are selected from one or more combinations of L-lactic acid, citric acid, malic acid, gluconic acid, and tartaric acid; feasible preservatives are one or more combinations of phenoxyethanol, sodium benzoate, potassium sorbate, benzyl alcohol, and ethylhexylglycerin.

[0012] In some embodiments with better results, the pH adjuster is L-lactic acid, and the preservative is phenoxyethanol. In this embodiment, the raw materials of the mousse wash are the following components in the indicated mass fractions: 1) Core antibacterial agent: 0.05%–0.5% PHMB; 2) Surfactant system: 2.0%–4.0% cocoylpropyl betaine, 1.0%–2.0% sodium lauroyl sarcosinate; 3) Moisturizing complex: 0.02%–0.08% sodium hyaluronate, 0.2%–0.6% panthenol, 0.05%–0.15% dipotassium glycyrrhizate; 4) Additives: 1.0%–2.0% propylene glycol, 2.0%–4.0% glycerin, 0.05%–0.10% disodium EDTA; 5) pH adjuster: L-lactic acid, to adjust the pH to 5.0–6.0; 6) Preservative: Phenoxyethanol 0.3%–0.6%; The remainder is water for injection, totaling 100%.

[0013] Secondly, a method for preparing the mousse wash described in the first aspect is provided, comprising the following steps: S1. Preparation of aqueous phase: Weigh 60-80% of the formulation amount of water for injection, heat to 40-60℃, and add EDTA-disodium, glycerol and propylene glycol in sequence under stirring until completely dissolved to obtain the aqueous phase; S2. Adding surfactants: Add cocoylpropyl betaine and sodium lauroyl sarcosinate sequentially to the aqueous phase, and stir thoroughly until the solution is homogeneous and transparent; S3. Add the remaining ingredients: After the solution obtained in step (2) has cooled to below 35°C, add sodium hyaluronate, panthenol, and dipotassium glycyrrhizate, and stir until evenly dispersed; add PHMB until completely mixed with the aqueous phase; S4. pH adjustment and volume determination: Add L-lactic acid to slowly adjust the pH of the system to 5.0–6.0, and add water for injection to 100% to obtain the final product.

[0014] The reaction apparatus most suitable for the above preparation method is an emulsification homogenizing device, such as an emulsifying pot high-shear homogenizing emulsifier, a vacuum homogenizing emulsifier, a pipeline emulsifying pump, a bottom-type homogenizer, a high-speed disperser, a colloid mill, a high-pressure homogenizer, or a planetary stirring homogenizer; in one embodiment verified by the present invention, an emulsifying pot is used.

[0015] In addition, the stirring speed involved in the above preparation method is 150~450 r / min, which can be appropriately accelerated or decelerated depending on the different components added. For example, in S1, the stirring speed is 150~250 r / min and the stirring time is 3~7 min.

[0016] For example, in S2, the stirring speed is 380~450 r / min, and the stirring is carried out for 10~20 min until dissolved.

[0017] For example, in S3, the stirring speed is 220~270 r / min and the stirring time is 6~8 min.

[0018] Compared with the prior art, the beneficial effects of the present invention are: 1. Highly effective and safe antibacterial: Using PHMB as the core bactericidal ingredient, it can effectively kill pathogens at an effective concentration of 0.05%–0.5%, and is non-irritating and non-sensitizing, making it suitable for long-term mucosal care.

[0019] 2. Gentle repair of the skin barrier: The formula is generally mildly acidic and contains hyaluronic acid and panthenol. While cleansing and inhibiting bacteria, it can soothe dry skin, repair damaged barriers, and improve skin comfort.

[0020] 3. Advantages of the mousse formulation: Through a special surfactant compound and thickening system, a dense and delicate mousse foam is formed, which increases the contact area between the product and the skin, improves the cleaning efficiency, and is non-dripping, easy to rinse, and provides an excellent user experience. Detailed Implementation

[0021] It should be noted that the following detailed description is illustrative and intended to provide further explanation of the invention. Unless otherwise specified, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains.

[0022] It should be noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to limit the scope of exemplary embodiments according to the invention. As used herein, the singular form is intended to include the plural form as well, unless the context clearly indicates otherwise. Furthermore, it should be understood that when the terms "comprising" and / or "including" are used in this specification, they indicate the presence of features, steps, operations, devices, components, and / or combinations thereof.

[0023] In the context of this specification, the word "comprising" is considered to mean "especially including". It should not be interpreted as "consisting of only".

[0024] In the description of this application, it should be understood that the term "and / or" describes a relationship between related objects, indicating that three relationships can exist. For example, A and / or B can represent: A existing alone, A and B existing simultaneously, or B existing alone. The symbol " / " in this document indicates that the related objects are in an "or" relationship; for example, A / B means A or B.

[0025] In the description of the embodiments in this application, the words "exemplary" or "for example" are used to indicate that they are examples, illustrations, or descriptions. Any embodiment or design that is described as "exemplary" or "for example" in the embodiments of this application should not be construed as being more preferred or advantageous than other embodiments or design options. Specifically, the use of the words "exemplary" or "for example" is intended to present the relevant concepts in a specific manner.

[0026] In the description of the embodiments in this application, unless otherwise stated, "multiple" means two or more.

[0027] To enable those skilled in the art to better understand the technical solution of the present invention, the technical solution of the present invention will be described in detail below with reference to specific embodiments and comparative examples.

[0028] Example 1 In this embodiment, a mousse wash for male genitalia is provided, wherein the raw materials of the wash are the following components in the indicated mass fractions: 20% PHMB solution: 1.5%, corresponding to an effective PHMB concentration of 0.3%. Cocoylpropyl betaine: 3.0% Sodium lauroyl sarcosinate: 1.5% Sodium hyaluronate: 0.05% Panthenol: 0.4% Dipotassium glycyrrhizate: 0.1% EDTA-disodium: 0.08% Propylene glycol: 1.5% Glycerin: 3.0% Phenoxyethanol: 0.5% L-lactic acid: appropriate amount Add water for injection to 100%.

[0029] The preparation steps are as follows: 1. Preparation of aqueous phase: Add 70% of the formulation amount of water for injection to the emulsification pot, heat to 45°C, start stirring (200 r / min), add EDTA-disodium, glycerol and propylene glycol in sequence, and stir for 5 minutes until completely dissolved.

[0030] 2. Add surfactant: Keep the temperature at 45℃, add cocoylpropyl betaine and sodium lauroyl sarcosinate to the above mixture in sequence, increase the speed to 400r / min, stir for 12 minutes until the system is clear and free of particles.

[0031] 3. Adding mild ingredients: Stop heating and allow to cool naturally to below 35°C. Add sodium hyaluronate, panthenol, and dipotassium glycyrrhizate. Stir at low speed (250 rpm) for 10 minutes to disperse evenly.

[0032] 4. Antibacterial system formulation: Add 20% PHMB solution and continue stirring for 8 minutes to ensure that the cationic components are completely mixed with the aqueous phase.

[0033] 5. pH adjustment and volume adjustment: Add L-lactic acid to slowly adjust the pH of the system to 5.5, add water for injection to 100%, and stir well.

[0034] 6. Filtration and filling: After filtering through a 200-mesh filter cloth, the liquid is injected into the mousse pump head packaging bottle and sealed to obtain the finished product.

[0035] Example 2 In this embodiment, another mousse wash for male genitalia is provided, wherein the raw materials of the wash are the following components in the indicated mass fractions: 20% PHMB solution: 0.25%, corresponding to an effective PHMB concentration of 0.05%. Cocoylpropyl betaine: 2.0% Sodium lauroyl sarcosinate: 2% Sodium hyaluronate: 0.02% Panthenol: 0.6% Dipotassium glycyrrhizate: 0.15% EDTA-disodium: 0.05% Propylene glycol: 2.0% Glycerin: 2.0% Phenoxyethanol: 0.3% L-lactic acid: appropriate amount Add water for injection to 100%.

[0036] The preparation steps are as follows: 1. Aqueous phase preparation: Add 60% of the formulation amount of water for injection to the emulsification pot, heat to 40°C, start stirring (200 r / min), add EDTA-disodium, glycerol and propylene glycol in sequence, and stir for 5 minutes until completely dissolved.

[0037] 2. Add surfactant: Keep the temperature at 45℃, add cocoylpropyl betaine and sodium lauroyl sarcosinate to the above mixture in sequence, increase the speed to 400r / min, stir for 12 minutes until the system is clear and free of particles.

[0038] 3. Adding mild ingredients: Stop heating and allow to cool naturally to below 35°C. Add sodium hyaluronate, panthenol, and dipotassium glycyrrhizate. Stir at low speed (250 rpm) for 10 minutes to disperse evenly.

[0039] 4. Antibacterial system formulation: Add 20% PHMB solution and continue stirring for 8 minutes to ensure that the cationic components are completely mixed with the aqueous phase.

[0040] 5. pH adjustment and volume adjustment: Add L-lactic acid to slowly adjust the pH of the system to 5.5, add water for injection to 100%, and stir well.

[0041] 6. Filtration and filling: After filtering through a 200-mesh filter cloth, the liquid is injected into the mousse pump head packaging bottle and sealed to obtain the finished product.

[0042] Example 3 In this embodiment, another mousse wash for male genitalia is provided, wherein the raw materials of the wash are the following components in the indicated mass fractions: 20% PHMB solution: 2.5%, corresponding to an effective PHMB concentration of 0.5%. Cocoylpropyl betaine: 4.0% Sodium lauroyl sarcosinate: 1.0% Sodium hyaluronate: 0.08% Panthenol: 0.2% Dipotassium glycyrrhizate: 0.05% EDTA-disodium: 0.1% Propylene glycol: 1.0% Glycerin: 4.0% Phenoxyethanol: 0.6% L-lactic acid: appropriate amount Add water for injection to 100%.

[0043] The preparation steps are as follows: 1. Aqueous phase preparation: Add 80% of the formulation amount of water for injection to the emulsification pot, heat to 60°C, start stirring (200 r / min), add EDTA-disodium, glycerol and propylene glycol in sequence, and stir for 5 minutes until completely dissolved.

[0044] 2. Add surfactant: Keep the temperature at about 45°C, add cocoylpropyl betaine and sodium lauroyl sarcosinate to the above mixture in sequence, increase the speed to 400 r / min, stir for 12 minutes until the system is clear and free of particles.

[0045] 3. Adding mild ingredients: Stop heating and allow to cool naturally to below 35°C. Add sodium hyaluronate, panthenol, and dipotassium glycyrrhizate. Stir at low speed (250 rpm) for 10 minutes to disperse evenly.

[0046] 4. Antibacterial system formulation: Add 20% PHMB solution and continue stirring for 8 minutes to ensure that the cationic components are completely mixed with the aqueous phase.

[0047] 5. pH adjustment and volume adjustment: Add L-lactic acid to slowly adjust the pH of the system to 5.5, add water for injection to 100%, and stir well.

[0048] 6. Filtration and filling: After filtering through a 200-mesh filter cloth, the liquid is injected into the mousse pump head packaging bottle and sealed to obtain the finished product.

[0049] Comparative Example 1 In this embodiment, another mousse wash for male genitalia is provided. The difference from Example 1 is that the raw materials do not contain dipotassium glycyrrhizate, while the mass fraction of the other components remains unchanged.

[0050] Comparative Example 2 In this embodiment, another mousse wash for male genitalia is provided. The difference from Example 1 is that the raw materials do not contain panthenol, while the mass fraction of the other components remains unchanged.

[0051] Comparative Example 3 In this embodiment, another mousse wash for male private parts is provided. The difference from Example 1 is that the raw materials do not contain sodium hyaluronate, while the mass fraction of the other ingredients remains unchanged.

[0052] Performance testing (a) Skin irritation The intact skin irritation test (rabbit method) was conducted according to Appendix F of GB15979-2024 and the requirements of GB / T38496. Several healthy adult white rabbits were selected, and the fur on both sides of their backs was shaved 24 hours before the test, with each side covering an area of ​​approximately 3cm × 3cm. 0.5mL of the undiluted wash solution from Examples 1-3 and Comparative Examples 1-3 was evenly applied to the shaved area on the left side, and an equal amount of physiological saline was applied to the right side as a blank control. The treatment was carried out once a day for 3 consecutive days, and the solution was left on for 4 hours after each application before washing with warm water. The skin erythema and edema were observed at 1 hour, 24 hours after each application, and 48 hours and 72 hours after the last application.

[0053] Tests showed that no erythema or edema appeared on the rabbit skin after application of the above-mentioned examples and comparative examples, proving that the obtained mousse wash was non-irritating.

[0054] (ii) Stability test Examples 1-3 and Comparative Example 1 Three bottles of each of the 3% mousse wash solution were placed in their original packaging in a 48℃ constant temperature chamber for 24 hours to complete the high-temperature test. Another three bottles of the same batch were placed in their original packaging in a -15℃ low-temperature chamber for 24 hours to complete the low-temperature test. After the high and low temperature treatment, the samples were taken out and brought to room temperature (25℃±2℃). The appearance of the samples, whether they were layered, clumped, discolored, had an off-odor, had broken bubbles, or had any abnormalities in the liquid were observed and recorded. At the same time, the foam was pressed out to check the foam state and the uniformity of the system. The test was repeated three times in parallel to determine the stability results.

[0055] According to the test results, the mousse wash liquid described in Examples 1-3 showed no stratification, clumping, or discoloration after high temperature (48℃ / 24h) and low temperature (-15℃ / 24h) stability tests. Comparative Example 1 showed a small amount of clumping after high temperature stability test, Comparative Example 2 showed no obvious stratification, and Comparative Example 3 showed a certain degree of clumping and stratification after both high temperature and low temperature stability tests.

[0056] The stability test results indicate that sodium hyaluronate plays an important role in maintaining the homogeneity and stability of the mixture system. Secondly, dipotassium glycyrrhizate also helps to maintain the high-temperature stability of the system to a certain extent.

[0057] (II) Antibacterial effect The antibacterial test method in Appendix E of GB 15979-2024 was adopted. *Escherichia coli* CICC 10899, *Staphylococcus aureus* ATCC 6538, and *Candida albicans* ATCC 10231 were used as test strains. 0.5 mL of freshly prepared suspensions of *E. coli*, *Staphylococcus aureus*, and *Candida albicans* were added dropwise to 4.5 mL of sample solution and mixed thoroughly. After the specified incubation time, 0.5 mL of the bacterial-antibiotic mixture was added to 4.5 mL of diluent and mixed thoroughly. 1.0 mL of the sample solution was inoculated into Petri dishes, with two dishes in parallel per tube. Nutrient agar (for bacteria) or Saburg agar (for yeast) at 40–45℃ was poured in, mixed thoroughly, and allowed to solidify. The dishes were then incubated at 36℃±1℃ for 48 h for bacteria and 72 h for yeast. Viable colony counts were performed. The diluent was used as a positive control instead of the sample. The test was repeated three times, and the inhibition rate was calculated using the formula. The results are shown in Table 1 below. Table 1. Antibacterial rate of the washing solutions obtained in the examples and comparative examples. As shown in Table 1, Examples 1, 2, and 3 all exhibited inhibition rates ≥99.99% against Escherichia coli, Staphylococcus aureus, and Candida albicans, demonstrating excellent and stable antibacterial effects. Comparative Example 1 (without dipotassium glycyrrhizate) and Comparative Example 2 (without panthenol) showed significantly reduced inhibition rates against the three strains, ranging from only 90.25% to 98.27%, failing to achieve a highly effective antibacterial level. Comparative Example 3 (without sodium hyaluronate) maintained an inhibition rate ≥99.99%, comparable to Example 1. These results indicate that dipotassium glycyrrhizate and panthenol synergistically participate in the antibacterial effect of the system; the absence of either significantly weakens the antibacterial efficiency of PHMB, while the absence of sodium hyaluronate has no significant impact on the antibacterial effect. This demonstrates that the formulation of this invention achieves stable and highly effective antibacterial action through multi-component synergy.

[0058] (III) Foaming effect According to the sensory evaluation standards for cosmetics, Example 1 and Comparative Example 1 were selected. Three samples of each type were collected and continuously pumped at the same force using the same mousse pump head at a constant temperature of 25°C. Foam was collected at the 3rd, 5th, and 10th pumps, and the foam height was immediately measured and the time to complete foam collapse (half-life, 25°C) was recorded. Three evaluators then blindly tested the foam fineness. A sensory score of 10 was used, and the results were measured in three parallel trials. The average value and relative standard deviation of the foam height, half-life, and sensory score were statistically analyzed to determine the foaming adequacy, fineness, and stability.

[0059] Table 2. Foaming effects of the examples and comparative examples 1-3 As shown in Table 2, Example 1 exhibited a foam height ≥120mm, a half-life ≥30min, and a fineness score of 9.2, demonstrating sufficient foaming, dense foam, and optimal stability. Comparative Example 1 (without dipotassium glycyrrhizate) showed slightly lower performance across all indicators compared to Example 1, but still maintained good foaming and stability. Comparative Example 2 (without panthenol) showed a significant decrease in foam height, half-life, and fineness, with weakened foam support. Comparative Example 3 (without sodium hyaluronate) showed the most significant decrease, with a foam height only ≥98mm, a half-life ≥12min, and a fineness score of only 7.5, indicating insufficient foaming, easy collapse, and a noticeable roughness. The results indicate that sodium hyaluronate is a key component for improving foam height, fineness, and stability; panthenol makes a significant contribution to foam structure and durability; and dipotassium glycyrrhizate helps maintain foam quality. The synergistic combination of these three components ensures the optimal user experience for the mousse.

[0060] The above description is merely a preferred embodiment of the present invention and is not intended to limit the invention. Various modifications and variations can be made to the present invention by those skilled in the art. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the scope of protection of the present invention.

Claims

1. A male cosmeceutical wash containing PHMB, characterized in that, The raw materials of the mousse wash include at least the following components: 1) Core antibacterial agent: PHMB; 2) Cleaning system: Cocoylpropyl Betaine, Sodium Lauroyl Sarcosinate; 3) Moisturizing complex: Sodium hyaluronate, panthenol, dipotassium glycyrrhizate; 4) Additives: Propylene glycol, glycerin, disodium EDTA.

2. The male hyaluronic acid wash containing PHMB as described in claim 1, characterized in that, The mousse wash also includes other excipients, such as pH adjusters and preservatives. The pH adjuster is selected from one or more combinations of L-lactic acid, citric acid, malic acid, gluconic acid, and tartaric acid. The preservative is one or more combinations of phenoxyethanol, sodium benzoate, potassium sorbate, benzyl alcohol, and ethylhexylglycerin.

3. The male hyaluronic acid wash containing PHMB as described in claim 2, characterized in that, The pH adjuster is L-lactic acid, the preservative is phenoxyethanol, and the raw materials of the mousse wash are the following components in the indicated mass fractions: 1) Core antibacterial agent: 0.05%–0.5% PHMB; 2) Surfactant system: 2.0%–4.0% cocoylpropyl betaine, 1.0%–2.0% sodium lauroyl sarcosinate; 3) Moisturizing complex: 0.02%–0.08% sodium hyaluronate, 0.2%–0.6% panthenol, 0.05%–0.15% dipotassium glycyrrhizate; 4) Additives: 1.0%–2.0% propylene glycol, 2.0%–4.0% glycerin, 0.05%–0.10% disodium EDTA; 5) pH adjuster: L-lactic acid, to adjust the pH to 5.0–6.0; 6) Preservative: Phenoxyethanol 0.3%–0.6%; The remainder is water for injection, totaling 100%.

4. The method for preparing the mousse wash according to any one of claims 1-3, characterized in that, Includes the following steps: S1. Preparation of aqueous phase: Weigh 60-80% of the formulation amount of water for injection, heat to 40-60℃, and add EDTA-disodium, glycerol and propylene glycol in sequence under stirring until completely dissolved to obtain the aqueous phase; S2. Adding surfactants: Add cocoylpropyl betaine and sodium lauroyl sarcosinate sequentially to the aqueous phase, and stir thoroughly until the solution is homogeneous and transparent; S3. Add the remaining ingredients: After the solution obtained in step (2) has cooled to below 35°C, add sodium hyaluronate, panthenol, and dipotassium glycyrrhizate, and stir until evenly dispersed; add PHMB until completely mixed with the aqueous phase; S4. pH adjustment and volume determination: Add L-lactic acid to slowly adjust the pH of the system to 5.0–6.0, and add water for injection to 100% to obtain the final product.

5. The method for preparing the mousse wash as described in claim 4, characterized in that, The reaction apparatus used in the preparation method is an emulsification homogenizing device; Further, it is selected from one of the following: emulsifying pot, high-shear homogenizing emulsifier, vacuum homogenizing emulsifier, inline emulsifying pump, bottom homogenizer, high-speed disperser, colloid mill, high-pressure homogenizer, and planetary mixing homogenizer.

6. The method for preparing the mousse wash as described in claim 5, characterized in that, The reaction apparatus is an emulsifying pot.

7. The method for preparing the mousse wash as described in claim 4, characterized in that, The stirring speed involved in the preparation method is 150~450 r / min.

8. The method for preparing the mousse wash as described in claim 7, characterized in that, In S1, the stirring speed is 150~250 r / min, and the stirring time is 3~7 min; In step S2, the stirring speed is 380~450 r / min, and the stirring is carried out for 10~20 min until dissolved; In S3, the stirring speed is 220~270 r / min, and the stirring time is 6~8 min.

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