A low-irritation natural soap liquid suitable for cleansing the skin around the eyes and its preparation method

Abstract

This invention relates to the field of eye area cleansing technology, providing a low-irritation natural soap solution suitable for cleaning the skin around the eyes and its preparation method, solving the problems of poor cleansing effect and easy irritation of the eye area in existing eye area cleansing products; the soap solution consists of an aqueous phase and an oil phase; the aqueous phase, by weight percentage of the total soap solution, includes the following components: 8%-12% amino acid surfactant, 3%-5% alkyl glycoside, 3%-5% moisturizer, 0.6%-1.3% soothing agent, 0.1%-0.3% natural antibacterial agent, 0.05%-0.1% pH adjuster, 0.5%-1.0% compound plant extract, with the balance being deionized water; the oil phase, by weight percentage of the total soap solution, includes the following components: 18%-28% natural plant oil, 2%-3% natural emulsifier.

Description

Technical Field

[0001] This invention relates to the field of eye area cleansing technology, and in particular to a low-irritation natural soap liquid suitable for cleaning the skin around the eyes and its preparation method. Background Technology

[0002] Periocular skin cleansing is a crucial step in preoperative preparation of the surgical area, pre-treatment before precision optical examinations, and auxiliary care for ocular surface diseases. It is essential for ensuring surgical safety, accurate examinations, and eye health. Patients often have residual sunscreen, foundation, eyeshadow, mascara, and other makeup around their eyes, or excessive oil and metabolic waste. These residues can interfere with the observation field of precision optical instruments such as slit-lamp microscopes and fundus cameras, leading to misdiagnosis or missed diagnosis. More seriously, if scattered cosmetic particles flow into the conjunctival sac or ocular surface with tears, they can easily cause secondary infections or contact dermatitis, posing a potential risk to the patient's eye health.

[0003] Currently, commonly used clinical methods for eye cleaning mainly include wiping with saline-soaked cotton swabs, rinsing with ordinary medical eye wash, or washing with soapy water. However, these methods have shortcomings in practical application: First, saline and ordinary eye wash are mainly effective against water-soluble dirt and have poor dissolving power against waterproof makeup and stubborn oils, often requiring repeated vigorous wiping. This not only increases the workload of medical staff but also damages the patient's delicate eyelid skin and eyelash follicles due to excessive mechanical friction. Second, traditional soapy water or ordinary soap is mostly highly alkaline (pH>9), and its free alkaline components can easily irritate the cornea and conjunctiva, causing patients to experience severe discomfort such as eye pain and tearing, and even disrupting the acid-base balance of the tear film. Third, although some commercially available makeup removers or cleansing milks have strong cleaning power, incomplete emulsification can easily leave oil residue, clogging the meibomian gland openings and inducing or aggravating meibomian gland dysfunction (MGD). Furthermore, the fragrances, preservatives, and emulsifiers they contain pose a high risk of sensitization to the ocular surface after surgery or in an inflammatory state.

[0004] Chinese Patent Publication No. CN105362157A discloses an antibacterial soap liquid for surgical handwashing and its preparation process. It is composed of green grape seed oil, peony seed oil, grapefruit extract, oleuropein, chlorhexidine gluconate, natural wild chrysanthemum extract, potassium hydroxide, sodium cocoyl hydroxyethyl sulfonate, and water. The mass percentages of each component are as follows: green grape seed oil 20-30 parts; peony seed oil 120-150 parts; grapefruit extract 0.5-1.0 parts; oleuropein 1.5-2.5 parts; chlorhexidine gluconate 1.0-2.0 parts; natural wild chrysanthemum extract 0.5-1.0 parts; potassium hydroxide 2.2-3.0 parts; sodium cocoyl hydroxyethyl sulfonate 0.5-3.0 parts; and the remainder is water. This invention's antibacterial soap is phosphate-free and possesses natural properties; it is an ultra-low-foaming detergent, making it easier to rinse; it uniquely contains a special calcium soap dispersant, resulting in stronger detergency; it also contains natural wild chrysanthemum extract, providing a refreshing and clean feeling, with a gentle, moisturizing, and rich fragrance that leaves a lingering scent on hands; and it exhibits significant antibacterial effects against Staphylococcus aureus and Candida albicans. However, this soap contains potassium hydroxide, making the system highly alkaline (pH>9), which may easily cause eye irritation.

[0005] Chinese Patent Publication No. CN119679639A discloses a skin-protecting medical adhesive remover and its preparation method. The oil phase includes squalane and cyclic siloxane, and the aqueous phase uses water as a solvent and includes a surfactant and a polyol. The surfactant is composed of decyl glucoside and cocamidopropyl betaine in a weight ratio of 1:1 to 2:1. The composition of this invention is applied to medical devices (such as adhesive tape, tension relievers, and surgical dressings) adhered to the skin, and then the medical device is peeled off. Verification showed that the peeling force on the medical device is significantly reduced; compared to three commercially available adhesive removers, the peeling force is also significantly reduced by nearly half. It has minimal skin irritation, comparable to physiological saline, and can gently remove adhesive residue from the skin surface, avoiding the side effects caused by traditional solvent-based products. Although this medical adhesive remover can achieve highly efficient dirt removal, it is still irritating and cannot be used for cleaning around the eyes. Summary of the Invention

[0006] Therefore, in view of the above problems, the present invention provides a low-irritation natural soap liquid suitable for cleaning the skin around the eyes and its preparation method, which solves the problems of poor cleaning effect and easy irritation of the skin around the eyes in the prior art.

[0007] To achieve the above objectives, the present invention adopts the following technical solution: A low-irritation natural soap liquid suitable for cleansing the skin around the eyes, comprising an aqueous phase and an oil phase; the aqueous phase, by weight percentage of the total soap liquid, includes the following components: 8%-12% amino acid surfactant, 3%-5% alkyl glycoside, 3%-5% moisturizer, 0.6%-1.3% soothing agent, 0.1%-0.3% natural antibacterial agent, 0.05%-0.1% pH adjuster, 0.5%-1.0% compound plant extract, with the balance being deionized water; the oil phase, by weight percentage of the total soap liquid, includes the following components: 18%-28% natural plant oil, 2%-3% natural emulsifier; The compound plant extract is composed of Portulaca oleracea extract, aescin, and calendula extract; and the mass ratio of Portulaca oleracea extract, aescin, and calendula extract is (1-2):(0.5-1):(1-2). The soothing agent comprises panthenol and bisabolol; the mass ratio of panthenol to bisabolol is (3-5):1. The natural plant oils include jojoba oil, olive oil, and avocado oil; the mass ratio of the jojoba oil, olive oil, and avocado oil is (3-5):(2-3):1; The pH value of the soap solution is 6.5-7.5.

[0008] Furthermore, the natural antibacterial agent is glyceryl caprylate.

[0009] Furthermore, the amino acid surfactant is one or a mixture of two or more of the following in any proportion: potassium cocoyl glycinate, sodium cocoyl glutamate, and sodium lauroyl glutamate.

[0010] Furthermore, the alkyl glycoside is alkyl glycoside 0810 or alkyl glycoside 1214.

[0011] Furthermore, the moisturizer is one or a mixture of two or more of 1,3-propanediol, 1,3-butanediol, and glycerin in any proportion.

[0012] Furthermore, the natural emulsifier is a sucrose fatty acid ester or lecithin.

[0013] The preparation method of the low-irritation natural soap liquid suitable for cleansing the skin around the eyes described above includes the following steps: S1. Raw material preparation: Weigh each component according to its mass percentage; S2. Oil phase preparation: Add natural vegetable oil and natural emulsifier to the first reaction vessel, heat to 55℃-65℃, and stir until uniform and transparent to obtain the oil phase; S3. Preparation of aqueous matrix: Deionized water, amino acid surfactant, alkyl glycoside and humectant are added to the second reaction vessel, heated to 55℃-65℃ and stirred until completely dissolved to obtain aqueous matrix. S4. Emulsification and homogenization: Under stirring conditions, the oil phase obtained in step S2 is slowly added to the aqueous matrix for high-shear homogenization. The homogenization rate is 10000r / min-12000r / min and the homogenization time is 8min-10min to obtain a homogenized liquid. S5. Cooling and Post-Addition: Cool the homogenized liquid to ≤40℃, add the soothing agent, compound plant extract, natural antibacterial agent and pH adjuster, and stir evenly. S6. Volume Adjustment and Discharge: Detect and adjust the pH of the system to 6.5-7.5, add deionized water to 100%, and filter to obtain a low-irritation natural soap solution suitable for cleaning the skin around the eyes.

[0014] By adopting the aforementioned technical solution, the beneficial effects of the present invention are as follows: 1. Control the pH value of the soap solution to a neutral to slightly acidic range of 6.5-7.5, which is close to the natural pH value of human tears, thereby avoiding the strong irritation of the eye mucosa by traditional soap-based detergents (pH>9).

[0015] 2. Panthenol and bisabolol can soothe nerve endings during the cleansing process, reducing stinging and burning sensations, making them suitable for sensitive and delicate areas such as around the eyes.

[0016] 3. The compound plant extract composed of Portulaca oleracea extract, aescin, and calendula extract not only has a broad-spectrum anti-inflammatory effect, but also improves the microcirculation around the eyes and eliminates edema through aescin. It effectively prevents the aggravation of eye bags or eyelid swelling caused by friction or residue after cleaning, thus achieving both cleansing and maintenance.

[0017] 4. Natural plant oils, including jojoba oil, olive oil, and avocado oil, provide sufficient dissolving power while maintaining excellent skin affinity. Combined with alkyl glycosides, the product does not leave a slippery or greasy residue like traditional soaps during rinsing, exhibiting excellent hydrophilicity and rinsing easily with water. Detailed Implementation Example 1

[0018] A low-irritation natural liquid soap suitable for cleansing the skin around the eyes, comprising an aqueous phase and an oil phase; the aqueous phase, by weight percentage of the total soap liquid, includes the following components: 10% amino acid surfactant, 4% alkyl glycoside, 4% moisturizer, 1% soothing agent, 0.2% natural antibacterial agent, 0.08% pH adjuster, 0.8% compound plant extract, with the balance being deionized water; the oil phase, by weight percentage of the total soap liquid, includes the following components: 20% natural plant oil, 2% natural emulsifier; The compound plant extract is composed of Portulaca oleracea extract, aescin, and calendula extract; and the mass ratio of Portulaca oleracea extract, aescin, and calendula extract is 2:1:1. The soothing agent comprises panthenol and bisabolol; the mass ratio of panthenol to bisabolol is 4:1. The natural plant oils include jojoba oil, olive oil, and avocado oil; the mass ratio of the jojoba oil, olive oil, and avocado oil is 3:2:1. The soap solution has a pH of 7.0; the natural antibacterial agent is glyceryl caprylate; the amino acid surfactant is potassium cocoyl glycinate; the alkyl glycoside is alkyl glycoside O810; the moisturizer is 1,3-propanediol; the natural emulsifier is sucrose fatty acid ester; and the pH adjuster is a mixture of citric acid and malic acid in a 1:1 ratio.

[0019] The preparation method of the low-irritation natural soap liquid suitable for cleansing the skin around the eyes described above includes the following steps: S1. Raw material preparation: Weigh each component according to its mass percentage; S2. Oil phase preparation: Add natural vegetable oil and natural emulsifier to the first reaction vessel, heat to 60°C, and stir until uniform and transparent to obtain the oil phase; S3. Preparation of aqueous matrix: Deionized water, amino acid surfactant, alkyl glycoside and humectant are added to the second reaction vessel, heated to 60°C and stirred until completely dissolved to obtain the aqueous matrix. S4. Emulsification and homogenization: Under stirring conditions, the oil phase obtained in step S2 is slowly added to the aqueous matrix for high-shear homogenization at a homogenization rate of 10000 r / min and a homogenization time of 10 min to obtain a homogenized liquid. S5. Cooling and Post-Addition: Cool the homogenized liquid to 35°C, add the soothing agent, compound plant extract, natural antibacterial agent and pH adjuster, and stir evenly. S6. Volume Adjustment and Discharge: Detect and adjust the pH of the system to 7.0, add deionized water to 100%, and filter to obtain a low-irritation natural soap solution suitable for cleaning the skin around the eyes. Example 2

[0020] A low-irritation natural soap liquid suitable for cleansing the skin around the eyes, comprising an aqueous phase and an oil phase; the aqueous phase, by weight percentage of the total soap liquid, includes the following components: 8% amino acid surfactant, 3% alkyl glycoside, 3% moisturizer, 1.2% soothing agent, 0.15% natural antibacterial agent, 0.05% pH adjuster, 0.6% compound plant extract, with the balance being deionized water; the oil phase, by weight percentage of the total soap liquid, includes the following components: 25% natural plant oil, 2% natural emulsifier; The compound plant extract is composed of Portulaca oleracea extract, aescin, and calendula extract; and the mass ratio of Portulaca oleracea extract, aescin, and calendula extract is 2:1:1. The soothing agent comprises panthenol and bisabolol; the mass ratio of panthenol to bisabolol is 3:1. The natural plant oils include jojoba oil, olive oil, and avocado oil; the mass ratio of the jojoba oil, olive oil, and avocado oil is 4:3:1. The soap solution has a pH of 6.5; the natural antibacterial agent is glyceryl caprylate; the amino acid surfactant is sodium cocoyl glutamate; the alkyl glycoside is alkyl glycoside 1214; the moisturizer is glycerin; the natural emulsifier is lecithin; and the pH adjuster is a mixture of citric acid and malic acid in a ratio of 1.2:1.

[0021] The preparation method of the low-irritation natural soap liquid suitable for cleansing the skin around the eyes described above includes the following steps: S1. Raw material preparation: Weigh each component according to its mass percentage; S2. Oil phase preparation: Add natural vegetable oil and natural emulsifier to the first reaction vessel, heat to 55°C, and stir until uniform and transparent to obtain the oil phase; S3. Preparation of aqueous matrix: Deionized water, amino acid surfactant, alkyl glycoside and humectant are added to the second reaction vessel, heated to 55°C and stirred until completely dissolved to obtain aqueous matrix. S4. Emulsification and homogenization: Under stirring conditions, the oil phase obtained in step S2 is slowly added to the aqueous matrix for high-shear homogenization at a homogenization rate of 12000 r / min and a homogenization time of 8 min to obtain a homogenized liquid. S5. Cooling and Post-Addition: Cool the homogenized liquid to 40°C, add the soothing agent, compound plant extract, natural antibacterial agent and pH adjuster, and stir evenly. S6. Volume Adjustment and Discharge: Detect and adjust the pH of the system to 6.5, add deionized water to 100%, and filter to obtain a low-irritation natural soap solution suitable for cleaning the skin around the eyes. Example 3

[0022] A low-irritation natural liquid soap suitable for cleansing the skin around the eyes, comprising an aqueous phase and an oil phase; the aqueous phase, by weight percentage of the total soap liquid, includes the following components: 12% amino acid surfactant, 5% alkyl glycoside, 5% moisturizer, 1.3% soothing agent, 0.3% natural antibacterial agent, 0.1% pH adjuster, 1.0% compound plant extract, with the balance being deionized water; the oil phase, by weight percentage of the total soap liquid, includes the following components: 28% natural plant oil, 3% natural emulsifier; The compound plant extract is composed of Portulaca oleracea extract, aescin, and calendula extract; and the mass ratio of Portulaca oleracea extract, aescin, and calendula extract is 2:1:1. The soothing agent comprises panthenol and bisabolol; the mass ratio of panthenol to bisabolol is 3:1. The natural plant oils include jojoba oil, olive oil, and avocado oil; the mass ratio of the jojoba oil, olive oil, and avocado oil is 5:3:1. The pH value of the soap solution is 7.2.

[0023] The natural antibacterial agent is glyceryl caprylate; the amino acid surfactant is sodium lauroyl glutamate; the alkyl glycoside is alkyl glycoside O810; the moisturizer is 1,3-butanediol; the natural emulsifier is sucrose fatty acid ester; and the pH adjuster is a mixture of citric acid and malic acid, wherein the ratio of citric acid to malic acid is 1.5:1.

[0024] The preparation method of the low-irritation natural soap liquid suitable for cleansing the skin around the eyes described above includes the following steps: S1. Raw material preparation: Weigh each component according to its mass percentage; S2. Oil phase preparation: Add natural vegetable oil and natural emulsifier to the first reaction vessel, heat to 65°C, and stir until uniform and transparent to obtain the oil phase; S3. Preparation of aqueous matrix: Deionized water, amino acid surfactant, alkyl glycoside and humectant are added to the second reaction vessel, heated to 65°C and stirred until completely dissolved to obtain the aqueous matrix. S4. Emulsification and homogenization: Under stirring conditions, the oil phase obtained in step S2 is slowly added to the aqueous matrix for high-shear homogenization at a homogenization rate of 10000 r / min and a homogenization time of 10 min to obtain a homogenized liquid. S5. Cooling and Post-Addition: Cool the homogenized liquid to 35°C, add the soothing agent, compound plant extract, natural antibacterial agent and pH adjuster, and stir evenly. S6. Volume Adjustment and Discharge: Detect and adjust the pH of the system to 7.2, add deionized water to 100%, and filter to obtain a low-irritation natural soap solution suitable for cleaning the skin around the eyes.

[0025] Comparative Example 1 The difference from Example 1 is as follows: In step S5, instead of adding the compound plant extract, add an equal mass of deionized water.

[0026] Other technical solutions are the same as in Example 1.

[0027] The product prepared in Comparative Example 1 was tested on humans. After removing waterproof mascara, some subjects reported a slight burning sensation around their eyes. Furthermore, 30 minutes after cleansing, the skin around the eyes was slightly red, indicating that the product does not have the soothing and anti-inflammatory effects of the compound plant extracts.

[0028] Comparative Example 2 The difference from Example 1 is as follows: The natural plant oils include jojoba oil, olive oil, and avocado oil; the mass ratio of the jojoba oil, olive oil, and avocado oil is 1:1:1.

[0029] Other technical solutions are the same as in Example 1.

[0030] The product prepared in Comparative Example 2 could not form a stable microemulsion structure due to insufficient oil phase ratio. After standing for 24 hours, the product showed slight stratification and its cleaning ability decreased significantly, making it difficult to clean the oil around the eyes in one go.

[0031] Comparative Example 3 The difference from Example 1 is as follows: In step S4, under stirring conditions, the oil phase obtained in step S2 is slowly added to the aqueous matrix for high-shear homogenization at a homogenization rate of 5000 r / min for 3 min.

[0032] Other technical solutions are the same as in Example 1.

[0033] The product prepared in Comparative Example 3 had a cloudy appearance. Due to insufficient emulsification, the product felt rough on the skin when rinsed and had a noticeable gritty feel when wiped around the eyes.

[0034] The products prepared in Examples 1 to 3 and Comparative Examples 1 to 3 were subjected to performance tests, and the test results are shown in Table 1.

[0035] Table 1 Test Project Test methods Example 1 Example 2 Example 3 Comparative Example 1 Comparative Example 2 Comparative Example 3 pH value pH measurement (25℃) 7.0 6.5 7.2 7.0 7.0 7.0 Centrifugal stability Centrifuge at 3000 r / min for 30 min No stratification, no oil separation No stratification, no oil separation No stratification, no oil separation No layering Clearly layered Small amount of oil separation Appearance Visual observation Milky white microemulsion, fine and uniform A pale yellow, transparent liquid with good fluidity. Milky white microemulsion with a smooth texture milky white liquid Turbid liquid with floating oil droplets It is cloudy and has a noticeable grainy texture. Waterproof mascara cleanliness Artificial skin model, image analysis of residual rate after wiping 3 times 98.5% 97.8% 98.2% 96.5% 82.3% 88.5% Eyeliner cleanliness Artificial skin model, image analysis of residual rate after wiping 3 times 99.0% 98.5% 98.8% 97.0% 80.1% 85.0% Eye irritation index (0-5) Apply with eyes open, and rate the immediate stinging / burning sensation. 0.2 0.3 0.2 1.8 0.5 2.2 Skin redness index (EI) 30 minutes after cleansing, the ΔEI value was measured using a skin colorimeter. +1.5 +1.8 +1.6 +8.5 +2.0 Skin redness index (EI) Tightness after cleaning Subject self-rating (0-10 points, 0 points for no tightness) 0.5 0.6 0.4 1.0 3.5 4.0 Key Feedback Qualitative description Non-irritating and comfortable around the eyes Non-irritating and comfortable around the eyes Non-irritating and comfortable around the eyes Some people experience burning sensation around the eyes. It's greasy after cleaning and needs a second cleaning. It feels abrasive when wiping, and the area around the eyes feels dry after washing. Although the invention has been specifically shown and described in conjunction with preferred embodiments, those skilled in the art should understand that various changes in form and detail may be made to the invention without departing from the spirit and scope of the invention as defined in the appended claims, all of which shall be within the scope of protection of the invention.

Claims

1. A low irritant natural soap solution suitable for cleansing of periorbital skin, characterized in that, It consists of an aqueous phase and an oil phase. The aqueous phase, by weight percentage of the total soap solution, includes the following components: 8%-12% amino acid surfactant, 3%-5% alkyl glycoside, 3%-5% moisturizer, 0.6%-1.3% soothing agent, 0.1%-0.3% natural antibacterial agent, 0.05%-0.1% pH adjuster, 0.5%-1.0% compound plant extract, with the balance being deionized water. The oil phase, by weight percentage of the total soap solution, includes the following components: 18%-28% natural plant oil, 2%-3% natural emulsifier. The compound plant extract is composed of Portulaca oleracea extract, aescin, and calendula extract; and the mass ratio of Portulaca oleracea extract, aescin, and calendula extract is (1-2):(0.5-1):(1-2). The soothing agent comprises panthenol and bisabolol; the mass ratio of panthenol to bisabolol is (3-5):

1. The natural plant oils include jojoba oil, olive oil, and avocado oil; the mass ratio of the jojoba oil, olive oil, and avocado oil is (3-5):(2-3):1; The pH value of the soap solution is 6.5-7.

5.

2. A low irritant natural soap solution suitable for cleansing the periorbital skin as claimed in claim 1, wherein, The natural antibacterial agent is glyceryl caprylate.

3. The low-irritation natural soap liquid suitable for cleansing the skin around the eyes according to claim 1, characterized in that, The amino acid surfactant is one or a mixture of two or more of the following: potassium cocoyl glycinate, sodium cocoyl glutamate, and sodium lauroyl glutamate, in any proportion.

4. The low-irritation natural soap liquid suitable for cleansing the skin around the eyes according to claim 1, characterized in that, The alkyl glycoside is alkyl glycoside 0810 or alkyl glycoside 1214.

5. A low-irritation natural soap liquid suitable for cleansing the skin around the eyes according to claim 1, characterized in that, The moisturizer is one or a mixture of two or more of 1,3-propanediol, 1,3-butanediol, and glycerin in any proportion.

6. A low-irritation natural soap liquid suitable for cleansing the skin around the eyes according to claim 1, characterized in that, The natural emulsifier is sucrose fatty acid ester or lecithin.

7. The method for preparing a low-irritation natural soap liquid suitable for cleansing the skin around the eyes according to claim 1, characterized in that, Includes the following steps: S1. Raw material preparation: Weigh each component according to its mass percentage; S2. Oil phase preparation: Add natural vegetable oil and natural emulsifier to the first reaction vessel, heat to 55℃-65℃, and stir until uniform and transparent to obtain the oil phase; S3. Preparation of aqueous matrix: Deionized water, amino acid surfactant, alkyl glycoside and humectant are added to the second reaction vessel, heated to 55℃-65℃ and stirred until completely dissolved to obtain aqueous matrix. S4. Emulsification and homogenization: Under stirring conditions, the oil phase obtained in step S2 is slowly added to the aqueous matrix for high-shear homogenization. The homogenization rate is 10000r / min-12000r / min and the homogenization time is 8min-10min to obtain a homogenized liquid. S5. Cooling and Post-Addition: Cool the homogenized liquid to ≤40℃, add the soothing agent, compound plant extract, natural antibacterial agent and pH adjuster, and stir evenly. S6. Volume Adjustment and Discharge: Detect and adjust the pH of the system to 6.5-7.5, add deionized water to 100%, and filter to obtain a low-irritation natural soap solution suitable for cleaning the skin around the eyes.