Suture for pancreatic stump closure to prevent pancreatic juice leakage

CN122399085APending Publication Date: 2026-07-17THE FIRST AFFILIATED HOSPITAL OF ZHEJIANG CHINESE MEDICAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
THE FIRST AFFILIATED HOSPITAL OF ZHEJIANG CHINESE MEDICAL UNIVERSITY
Filing Date
2026-05-19
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing sutures are easily eroded and degraded by alkaline pancreatic juice when suturing pancreatic stumps, failing to effectively block the leakage of digestive enzymes, resulting in decreased tensile strength of the sutures and local tissue damage.

Method used

A composite coating consisting of hydroxypropyl cellulose and methyl methacrylate copolymer is used. The coating dissociates and releases tannic acid and zinc ions in an alkaline environment, forming precipitates that seal the suture gaps and inhibit digestive enzyme activity.

Benefits of technology

It effectively blocks pancreatic juice leakage, prevents suture degradation, maintains suture strength, inhibits the corrosive effect of digestive enzymes on tissues, and improves the sealing reliability and stability of sutures.

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Abstract

本发明涉及医疗器械技术领域,公开了防胰液渗漏的胰腺断端封闭用缝线,包括:基材和包覆于基材表面的复合涂层,复合涂层由羟丙基纤维素、甲基丙烯酸‑甲基丙烯酸甲酯共聚物、单宁酸和锌盐制成。当缝线接触弱碱性胰液时,共聚物羧基发生去质子化导致涂层氢键网络解体,释放出包载的单宁酸与锌离子。单宁酸与渗液中的游离消化酶结合,并在锌离子的配位交联作用下生成不溶性沉淀,以此填堵组织切口及针孔间隙,同时改变酶蛋白构象使其失活。本发明结合配液阶段的酸性调控与成膜阶段的分段式烘干工艺,保障了缝线涂层的致密附着,通过物理阻隔与化学抑酶协同阻断吻合部位的消化渗漏过程。
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