Cinnamaldehyde eugenol molecule top and its preparation method and application

Abstract

This invention provides a cinnamaldehyde-modified thymol molecular gyroscope, its preparation method, and its applications, belonging to the field of micro-area viscosity detection technology. The cinnamaldehyde-modified thymol molecular gyroscope of this invention uses the natural product α-hexylcinnamaldehyde and thymol oil as raw materials, and constructs a molecular structure through a specific reaction. It can serve as a molecular-level tool for controlling the viscosity of aromatic essential oils, effectively avoiding the shear-thinning effect that easily occurs when high molecular weight components in aromatic essential oils are used in viscosity detection, significantly reducing testing errors. This molecular gyroscope is highly sensitive to changes in the viscosity of thymol aromatic essential oils, providing non-destructive, real-time visual monitoring support for the essential oil preparation process, and is of great significance for the precise optimization and quality control of essential oil production processes.

Description

Technical Field

[0001] This invention relates to the field of micro-area viscosity detection technology, and in particular to a cinnamaldehyde-modified thymol molecular gyroscope, its preparation method, and its application. Background Technology

[0002] Thymol oil is a natural aromatic essential oil with thymol as its core active ingredient. It possesses multiple functions, including antibacterial and anti-inflammatory properties, insect repellent effects, skin soothing, and food preservation. It is widely used in skincare soothing preparations, aromatic compound oils, microemulsions, antibacterial gels, and food preservatives, making it a versatile natural raw material with diverse applications in the daily chemical, skincare, and food industries. The micro-viscosity of various thymol oil-based end products directly determines the product's flowability, skin adhesion and penetration, nutrient retention and sustained-release effects, and is also related to processing and transport performance and end-user experience. It is a key physical indicator concerning product quality and process stability, and precise monitoring and control of this viscosity are essential for improving the overall performance of thymol oil-derived products.

[0003] Microviscosity is a crucial parameter reflecting the resistance of a fluid's microscopic regions to deformation and its ability to impede the relative flow of adjacent fluid layers. Its microscopic changes directly dominate the macroscopic performance of thymol oil systems. Traditional viscosity testing methods rely heavily on macroscopic instruments such as falling ball viscometers, rotational viscometers, and vibrational viscometers. These methods not only require large sample volumes and are highly dependent on the equipment, but also lack sufficient sensitivity to microscopic viscosity changes, making it difficult to capture subtle fluctuations. Furthermore, thymol oil blends often contain oligomers and polymeric additives, which can lead to significant shear-thinning effects during testing, further amplifying errors and hindering accurate, in-situ microviscosity measurement at the molecular level. Currently, the industry lacks dedicated testing tools suitable for aromatic essential oil systems, highlighting a significant technological gap.

[0004] Currently, there is limited research on molecular-level micro-region viscosity sensors designed for aromatic essential oil systems such as thymol oil, which is insufficient to meet the industry's needs for refined detection and control. Against this backdrop, the development of cinnamaldehyde-modified thymol molecular gyroscopes has significant research and industrial value. Summary of the Invention

[0005] The purpose of this invention is to provide a cinnamaldehyde-modified thymol molecular gyroscope, its preparation method, and its application, so as to solve the problem of inaccurate micro-region viscosity detection of thymol aromatic essential oil in the prior art.

[0006] To achieve the above-mentioned objectives, the present invention provides the following technical solution: This invention provides a cinnamaldehyde-modified thymol molecular gyroscope, the structure of which is shown in Formula I:

[0007] Formula I.

[0008] The present invention also provides a method for preparing the above-mentioned cinnamaldehyde-modified thymol molecular gyroscope, comprising the following steps: mixing thymol solution and composite alkaline solution, adding cinnamaldehyde derivative solution to react, and obtaining cinnamaldehyde-modified thymol molecular gyroscope.

[0009] Preferably, the concentration of the thymol solution is 1-3 mol / L; the solvent of the thymol solution is one or more of acetone, butanone, ethyl acetate, tetrahydrofuran, 1,4-dioxane, N,N-dimethylformamide, acetonitrile, and dimethyl sulfoxide.

[0010] Preferably, the composite alkaline solution is prepared by mixing an inorganic alkaline solution and an organic alkaline solution.

[0011] Preferably, the inorganic alkali in the inorganic alkali solution includes one or more of sodium carbonate, sodium bicarbonate, and cesium carbonate; the solvent of the inorganic alkali solution is a mixed solvent of alcohol and water; and the concentration of the inorganic alkali solution is 1~5 mol / L.

[0012] Preferably, the organic base in the organic base solution comprises one or more of piperidine, betaine, choline, and quinoline; the solvent of the organic base solution is a mixture of a first solvent and a second solvent, wherein the first solvent comprises ethyl acetate, tetrahydrofuran, 1,4-dioxane, N,N-dimethylformamide, or acetonitrile, and the second solvent is ethanol; the volume ratio of the first solvent to the second solvent is 1~8:1; and the concentration of the organic base solution is 1~6 mol / L.

[0013] Preferably, the cinnamaldehyde derivative in the cinnamaldehyde derivative solution is α-hexylcinnamaldehyde, and the solvent is a mixture of an alcohol solvent and dimethyl sulfoxide; the concentration of the cinnamaldehyde derivative solution is 1~4 mol / L.

[0014] Preferably, the molar ratio of thymol, cinnamaldehyde derivative, inorganic base and organic base is 1~3:1~4:1~5:1~6.

[0015] Preferably, the reaction temperature is 90~130℃, and the reaction progress is monitored by thin-layer chromatography during the reaction.

[0016] This invention also provides an application of the above-described cinnamaldehyde-modified thymol molecular gyroscope in monitoring or detecting the viscosity of the physical microenvironment of thymol oil derivatives.

[0017] The beneficial effects of this invention are: This invention, a molecular gyroscope for cinnamaldehyde-modified thymol, fills the technological gap in the in-situ, real-time, and convenient detection of the viscosity of thymol aromatic essential oils in micro-regions. Using the natural product α-hexylcinnamaldehyde and thymol oil as main raw materials, its molecular structure, constructed through a specific reaction, can serve as a molecular-level tool for controlling the viscosity of aromatic essential oils. It effectively avoids the shear-thinning effect that easily occurs when high molecular weight components in aromatic essential oils are tested for viscosity, significantly reducing testing errors. This molecular gyroscope is highly sensitive to changes in the viscosity of thymol aromatic essential oils, providing non-destructive, real-time, and visual monitoring support for the essential oil preparation process, which is of great significance for the precise optimization and quality control of essential oil production processes.

[0018] The cinnamaldehyde-modified thymol molecular gyroscope of this invention leverages the structural advantages of natural raw materials to form a stable conjugated structure and excellent rotatability. The conjugated structure endows it with excellent pH and light stability, allowing it to remain stable in the complex system environment of aromatic essential oils for a long time. The rotatability enables it to accurately sense viscosity changes. The intensity of the released light signal conforms to the Förster-Hoffmann relationship function with the logarithmic function of the viscosity value of thymol aromatic essential oil, and the viscosity sensitivity coefficient reaches 0.65, exhibiting extremely high viscosity sensitivity. It is fully compatible with the detection needs of thymol aromatic essential oils from low viscosity to high viscosity, providing core structural support for detection accuracy.

[0019] The cinnamaldehyde thymol molecular gyroscope of this invention exhibits excellent spectroscopic performance, displaying a bright blue surface signal with high visual sensitivity and typical turn-on detection results. It can directly reflect the viscosity differences of thymol aromatic essential oils. Its peak wavelength is 428nm, effectively avoiding interference from the violet / ultraviolet emission bands in traditional aromatic essential oil detection. Furthermore, its Stokes shift exceeds 135nm, minimizing the impact of excitation light on the detection signal, significantly improving the signal-to-noise ratio, and ensuring clear and accurate detection signals even under the interference of complex essential oil components. The visual monitoring effect far surpasses traditional detection methods.

[0020] The cinnamaldehyde-modified thymol molecular gyroscope of this invention is prepared in one step. All required raw materials are derived from natural products—α-hexylcinnamaldehyde and natural thymol, the core component of thymol oil. The raw materials are widely available and environmentally friendly, avoiding the environmental burden and potential risks associated with synthetic raw materials. This preparation method is simple, requires no complex operations, has controllable overall preparation costs, and achieves high yields. It is a prime example of the cross-disciplinary, high-value application of natural product reconstruction in the field of aromatic essential oils. Furthermore, as a derivative functional molecule of thymol oil, this molecular gyroscope not only retains the natural properties of thymol but also enhances its comprehensive functions through structural modification. It has broad application potential in scenarios such as optimizing the formulation process of thymol aromatic essential oils, testing the quality of finished products, and monitoring storage stability, providing a new technological tool for the high-quality development of the aromatic essential oil industry. Attached Figure Description

[0021] Figure 1 This is a schematic diagram illustrating the mechanism of micro-area viscosity detection using the cinnamaldehyde-modified thymol molecular gyroscope obtained in Example 1. Figure 2 This is the high-resolution mass spectrum of the cinnamaldehyde thymol molecular gyroscope obtained in Example 1; Figure 3 The nuclear magnetic resonance spectrum of the cinnamaldehyde thymol molecular gyroscope obtained in Example 1; Figure 4 The emission spectra of the cinnamaldehyde thymol molecular gyroscope obtained in Example 1 in glycerol / water mixed solutions of different volume fractions are shown. Figure 5 The graph shows the linear fit of the logarithmic function of fluorescence intensity and viscosity value of the cinnamaldehyde thymol molecular gyroscope obtained in Example 1. Figure 6 The images show the photostability of the cinnamaldehyde-modified thymol molecular gyroscope obtained in Example 1 in glycerol and purified water, respectively. Figure 7 The pH stability test curve of the cinnamaldehyde thymol molecular gyroscope obtained in Example 1; Figure 8 The image shows the Stokes displacement test results of the cinnamaldehyde thymol molecular gyroscope obtained in Example 1. Figure 9 The spectrum of the cinnamaldehyde-modified thymol molecular gyroscope obtained in Example 1 in different commercially available thymol oil derivatives is shown. Detailed Implementation

[0022] This invention provides a cinnamaldehyde-modified thymol molecular gyroscope, the structure of which is shown in Formula I:

[0023] Formula I.

[0024] The present invention also provides a method for preparing the above-mentioned cinnamaldehyde-modified thymol molecular gyroscope, comprising the following steps: mixing thymol solution and composite alkaline solution, adding cinnamaldehyde derivative solution to react, and obtaining cinnamaldehyde-modified thymol molecular gyroscope.

[0025] In this invention, the concentration of the thymol solution is 1~3 mol / L, specifically 1 mol / L, 2 mol / L, or 3 mol / L; the solvent of the thymol solution is one or more of acetone, butanone, ethyl acetate, tetrahydrofuran, 1,4-dioxane, N,N-dimethylformamide, acetonitrile, and dimethyl sulfoxide.

[0026] In this invention, the preparation process of the thymol solution is as follows: thymol and solvent are mixed at room temperature, with a stirring speed of 600~1800 rpm, specifically 600 rpm, 800 rpm, 1000 rpm, 1200 rpm, 1400 rpm, 1600 rpm, and 1800 rpm, while ultrasonic vibration is performed during stirring, wherein the ultrasonic power is 10~40 kHz, specifically 10 kHz, 15 kHz, 20 kHz, 25 kHz, 30 kHz, 35 kHz, and 40 kHz; the mixing time is 0.2~1.0 h, specifically 0.2 h, 0.6 h, 0.8 h, and 1.0 h.

[0027] In this invention, the composite alkaline solution is prepared by mixing an inorganic alkaline solution and an organic alkaline solution.

[0028] In this invention, the inorganic alkali in the inorganic alkali solution includes one or more of sodium carbonate, sodium bicarbonate, and cesium carbonate; the solvent of the inorganic alkali solution is a mixed solvent of alcohol and water; the concentration of the inorganic alkali solution is 1~5 mol / L, specifically 1 mol / L, 2 mol / L, 3 mol / L, 4 mol / L, or 5 mol / L.

[0029] In this invention, the volume ratio of the alcohol solvent to water is 1 to 8:1, specifically 1:1, 2:1, 4:1, 6:1, or 8:1.

[0030] In this invention, the organic base in the organic base solution comprises one or more of piperidine, betaine, choline, and quinoline; the solvent of the organic base solution is a mixture of a first solvent and a second solvent, wherein the first solvent comprises ethyl acetate, tetrahydrofuran, 1,4-dioxane, N,N-dimethylformamide, or acetonitrile, and the second solvent is ethanol; the volume ratio of the first solvent to the second solvent is 1:1 to 6, specifically 1:1, 1:2, 1:3.5, 1:5, or 1:6; the concentration of the organic base solution is 1 to 6 mol / L, specifically 1 mol / L, 2 mol / L, 3 mol / L, 4 mol / L, 5 mol / L, or 6 mol / L.

[0031] In this invention, the preparation process of the organic base solution is as follows: the organic base and the solvent are mixed at a stirring rate of 300-900 rpm, specifically 300 rpm, 400 rpm, 500 rpm, 600 rpm, 700 rpm, 800 rpm, or 900 rpm; the mixing time is 0.1-0.9 h, specifically 0.1 h, 0.2 h, 0.3 h, 0.4 h, 0.5 h, 0.6 h, 0.7 h, 0.8 h, or 0.9 h.

[0032] In this invention, the cinnamaldehyde derivative in the cinnamaldehyde derivative solution is α-hexylcinnamaldehyde, and the solvent is a mixed solvent of alcohol and dimethyl sulfoxide; the concentration of the cinnamaldehyde derivative solution is 1~4 mol / L, specifically 1 mol / L, 2 mol / L, 3 mol / L, or 4 mol / L.

[0033] In this invention, the volume ratio of the alcohol solvent to dimethyl sulfoxide is 10 to 20:1, specifically 10:1, 12:1, 15:1, 18:1, or 20:1.

[0034] In this invention, the preparation process of the cinnamaldehyde derivative solution is as follows: the cinnamaldehyde derivative and the solvent are mixed, and nitrogen is continuously blown in at a rate of 5-20 mL / min, specifically 5 mL / min, 10 mL / min, 12.5 mL / min, 15 mL / min, 17.5 mL / min, or 20 mL / min; the stirring rate during mixing is 500-1500 rpm, specifically 500 rpm, 800 rpm, 1000 rpm, 1200 rpm, or 1500 rpm; the mixing time is 0.5-2.0 h, specifically 0.5 h, 1 h, 1.5 h, or 2 h.

[0035] In this invention, the organic alkaline solution is added to the inorganic alkaline solution by spraying at a rate of 5-12 mL / min, specifically 5 mL / min, 8.5 mL / min, 10 mL / min, or 12 mL / min. During the spraying process, continuous stirring is performed at a rate of 600-1800 rpm, specifically 600 rpm, 800 rpm, 1000 rpm, 1200 rpm, 1400 rpm, 1600 rpm, or 1800 rpm, to obtain a composite alkaline solution.

[0036] In this invention, the thymol solution is added to the composite alkaline solution by spraying, wherein the spraying rate is 4~12 mL / min, specifically 4 mL / min, 6 mL / min, 8 mL / min, 10 mL / min, or 12 mL / min. During the spraying process, the temperature is increased to 30~50℃, specifically 30℃, 40℃, or 50℃, and stirring is continuously performed at a stirring rate of 1000~2200 rpm, specifically 1000 rpm, 1200 rpm, 1400 rpm, 1600 rpm, 1800 rpm, 2000 rpm, or 2200 rpm.

[0037] In this invention, the molar ratio of thymol, cinnamaldehyde derivative, inorganic base and organic base is 1~3:1~4:1~5:1~6, specifically 1:1.5:2:3, 1:1:1:1, 1:4:5:6.

[0038] In this invention, the cinnamaldehyde derivative solution is added by spraying at a rate of 5-25 mL / min, specifically 5 mL / min, 10 mL / min, 15 mL / min, 20 mL / min, or 25 mL / min. During the spraying process, nitrogen gas is continuously introduced at a rate of 5-20 mL / min, specifically 5 mL / min, 12.5 mL / min, 15 mL / min, 17.5 mL / min, or 20 mL / min. Stirring is also performed continuously at a rate of 600-1600 rpm, specifically 600 rpm, 800 rpm, 1000 rpm, 1100 rpm, 1300 rpm, or 1600 rpm.

[0039] In this invention, the reaction temperature is 90~130℃, specifically 90℃, 100℃, 110℃, 120℃, or 130℃. Stirring is performed during the reaction, with a stirring rate of 1600~2500 rpm, specifically 1600 rpm, 1800 rpm, 2000 rpm, 2200 rpm, or 2500 rpm. Samples are taken every 2 hours during the reaction to monitor the reaction progress using thin-layer chromatography. The developing solvent is petroleum ether-ethyl acetate (volume ratio 5~8:1, specifically 5:1, 6.5:1, or 8:1). The reaction is stopped when the starting material spots disappear.

[0040] In this invention, after the reaction is completed, the reaction is sequentially cooled by nitrogen blowing, purified by dialysis, and dried by vacuum filtration.

[0041] In this invention, the specific steps of the cooling nitrogen blowing are as follows: after the reaction is completed, the mixture is cooled at room temperature, and then subjected to preliminary concentration and nitrogen blowing; the cooling time is 6~12h, specifically 6h, 9h, or 12h; the preliminary concentration temperature is 30~50℃, specifically 30℃, 40℃, or 50℃, and the vacuum degree is -0.09~-0.07MPa, specifically -0.09MPa, -0.08MPa, or -0.07MPa; the nitrogen blowing temperature is 40~50℃, specifically 40℃, 45℃, or 50℃, the nitrogen pressure is 0.1~0.2MPa, specifically 0.1MPa, 0.15MPa, or 0.2MPa, and the purging rate is 10~30mL / min, specifically 10mL / min, 20mL / min, or 30mL / min, until a yellow viscous crude product is obtained.

[0042] In this invention, the specific steps of the dialysis purification are as follows: the yellow viscous crude product is dissolved in N,N-dimethylformamide, and the resulting mixed solution is dialyzed; the concentration of the mixed solution is 10~50 mg / mL, specifically 10 mg / mL, 20 mg / mL, 30 mg / mL, 40 mg / mL, or 50 mg / mL; the molecular weight cutoff of the dialysis bag used for dialysis is 3500~8000 Da, specifically 3500 Da, 4000 Da, 5000 Da, 6000 Da, 7000 Da, or 8000 Da; the volume of the external liquid during dialysis is 10~30 times that of the internal liquid, specifically 10 times, 20 times, or 30 times; the external liquid is a mixture of ethanol and water; the dialysis time is 24~48 h, specifically 24 h, 36 h, 40 h, or 48 h; the external liquid is replaced every 8 h to remove unreacted raw materials, catalysts, and small molecule impurities.

[0043] In this invention, the specific steps of the vacuum filtration drying are as follows: after dialysis, the solution in the collection bag is sequentially filtered, crystals are precipitated, vacuum filtered, and freeze-dried; the filtration is performed using a 0.45 μm organic phase filter membrane; when precipitating crystals, the filtered solution is mixed with anhydrous ethanol-water mixed solvent and allowed to stand, wherein the ratio of crude product to mixed solvent is 3~7 mg:1 mL, specifically 3 mg:1 mL, 5 mg:1 mL, or 7 mg:1 mL; the volume ratio of anhydrous ethanol to water in the anhydrous ethanol-water mixed solvent is 1:2~4, specifically 1:2, 1:3, or 1:4; the standing temperature is 1~10℃, specifically 1℃, 3℃, 5.5℃, 7℃, or 10℃, and the standing time is 16~24 h, specifically 16 h. The filtration process involves 18h, 20h, 22h, and 24h. The filter paper used during filtration is medium-speed filter paper with 1-3 layers. The filtration flow rate is 0.4-0.8 mL / s, specifically 0.4 mL / s, 0.5 mL / s, 0.6 mL / s, 0.7 mL / s, and 0.8 mL / s. The vacuum degree during filtration is -0.09 to -0.07 MPa, specifically -0.09 MPa, -0.08 MPa, and -0.07 MPa. During filtration, the crystals are washed 1-3 times with a mixture of anhydrous ethanol and water at a flow rate of 0.2-0.8 mL / s, specifically 0.2 mL / s, 0.4 mL / s, 0.5 mL / s, 0.6 mL / s, and 0.8 mL / s. The freeze-drying temperature is -40°C. -15℃, specifically -40℃, -35℃, -28℃, -20℃, and -15℃, with freeze-drying time ranging from 36 to 54 hours, specifically 36 hours, 40 hours, 45 hours, 50 hours, and 54 hours.

[0044] This invention also provides an application of the above-described cinnamaldehyde-modified thymol molecular gyroscope in monitoring or detecting the viscosity of the physical microenvironment of thymol oil derivatives.

[0045] The technical solutions provided by the present invention will be described in detail below with reference to the embodiments, but they should not be construed as limiting the scope of protection of the present invention.

[0046] Example 1

[0047] 324.5 g (1.5 mol) of α-hexylcinnamaldehyde and solvent (ethanol and dimethyl sulfoxide in a volume ratio of 15:1) were mixed and stirred at 1000 rpm for 1 h at 25 °C and a nitrogen blowing rate of 12.5 mL / min to obtain a cinnamaldehyde derivative solution with a concentration of 2 mol / L. 150.22 g (1 mol) of natural thymol was mixed with a mixed solvent of acetone and ethyl acetate (the volume ratio of acetone and ethyl acetate was 1:1). The mixture was stirred at 1200 rpm at 25 °C and simultaneously subjected to ultrasonic oscillation at 25 kHz for 0.6 h to obtain a thymol solution with a concentration of 2 mol / L. 170.0 g (2 mol) of sodium bicarbonate and 1.0 L of anhydrous ethanol-purified water mixed solvent (volume ratio of anhydrous ethanol to purified water is 4:1) were mixed to obtain an inorganic alkaline solution (concentration of 2 mol / L); then 351.5 g (3 mol) of betaine and ethyl acetate-ethanol mixed solvent (volume ratio of ethyl acetate to ethanol is 1:3.5) were mixed and stirred at 600 rpm for 0.5 h to prepare an organic alkaline solution (concentration of 3 mol / L); then the organic alkaline solution was added to the inorganic alkaline solution at a spray rate of 8.5 mL / min, and the mixture was stirred continuously at 1200 rpm during the spraying process until the spraying was completed to obtain a composite alkaline solution; then thymol solution was added to the composite alkaline solution at a spray rate of 8 mL / min, and the temperature was raised to 40℃ during the spraying process, and the mixture was stirred continuously at 1600 rpm to obtain an alkalized thymol mixed solution; The cinnamaldehyde derivative solution was added to the alkalized thymol mixture at a spray rate of 15 mL / min. During the addition, nitrogen blowing was maintained at 12.5 mL / min, and the temperature was increased at a rate of 3.5 °C / min. The mixture was stirred continuously at 1100 rpm. When the temperature reached 110 °C, the stirring rate was increased to 2000 rpm to carry out the reaction. Samples were taken every 2 hours during the reaction, and the reaction progress was monitored by thin-layer chromatography (TCL). The developing solvent was petroleum ether-ethyl acetate (volume ratio of 6.5:1). The reaction was stopped when the starting material spots disappeared.

[0048] After the reaction was completed, the reaction solution was transferred to room temperature and cooled, and allowed to stand for 9 hours. The cooled reaction solution was then transferred to a rotary evaporator and initially concentrated at 40°C and a vacuum of -0.08 MPa to remove some of the solvent. Then, a nitrogen evaporator was used for precise concentration, with the nitrogen evaporation temperature set at 45°C, the nitrogen pressure at 0.15 MPa, and the purging rate at 20 mL / min, until a yellow viscous crude product was obtained. The crude product was dissolved in N,N-dimethylformamide to prepare a solution with a concentration of 30 mg / mL. The solution was then transferred into a dialysis bag with a molecular weight cutoff of 5000 Da. An ethanol-purified water mixture (volume ratio of 1:5) was used as the external dialysis solution, with the volume of the external solution being 20 times that of the internal solution. Dialysis was performed at room temperature for 36 hours, and the external solution was replaced every 8 hours. After dialysis, the solution in the bag was collected and filtered through a 0.45 μm organic phase filter membrane. The filtered solution was mixed with anhydrous ethanol-purified water (volume ratio 1:3), with a crude product to solvent ratio of 5 mg:1 mL. The mixture was allowed to stand at 5.5 °C for 20 h to precipitate crystals. The crystals were then filtered using medium-speed filter paper (2 layers) at a flow rate of 0.6 mL / s and a vacuum of -0.08 MPa. During filtration, the crystals were washed twice with anhydrous ethanol-purified water (volume ratio 1:5.5) at a flow rate of 0.5 mL / s. The crystals obtained after filtration were freeze-dried at -28 °C for 45 h to obtain 322.4 g of cinnamaldehyde thymol powder, i.e., cinnamaldehyde thymol molecular gyroscope, denoted as "BNIP", with a calculated yield of 92.5%.

[0049] Example 2

[0050] 216.32 g (1 mol) of α-hexylcinnamaldehyde was mixed with a solvent (ethanol and dimethyl sulfoxide in a volume ratio of 10:1) and stirred at 500 rpm for 2 h at 25 °C and a nitrogen blowing rate of 5 mL / min to obtain a cinnamaldehyde derivative solution with a concentration of 1 mol / L. 150.22 g (1 mol) of natural thymol was mixed with a mixed solvent of acetone and ethyl acetate (the volume ratio of acetone and ethyl acetate was 1:1). The mixture was stirred at 600 rpm at 25 °C and simultaneously subjected to ultrasonic oscillation at 10 kHz for 1.0 h to obtain a thymol solution with a concentration of 1 mol / L. 85.0 g (1 mol) of sodium bicarbonate and 1.0 L of anhydrous ethanol-purified water mixed solvent (volume ratio of anhydrous ethanol to purified water is 1:1) were mixed to obtain an inorganic base solution (concentration of 1 mol / L); then 117.2 g (1 mol) of betaine and ethyl acetate-ethanol mixed solvent (volume ratio of ethyl acetate to ethanol is 1:1) were mixed and stirred at 300 rpm for 0.9 h to prepare an organic base solution (concentration of 1 mol / L); then the organic base solution was added to the inorganic base solution at a spray rate of 5 mL / min, and the mixture was stirred continuously at 600 rpm during the spraying process until the spraying was completed to obtain a composite alkaline solution; then thymol solution was added to the composite alkaline solution at a spray rate of 4 mL / min, and the temperature was raised to 30℃ during the spraying process, and the mixture was stirred continuously at 1000 rpm to obtain an alkalized thymol mixed solution; The cinnamaldehyde derivative solution was added to the alkalized thymol mixture at a spray rate of 5 mL / min, with nitrogen blowing maintained at 5 mL / min during the addition process. The temperature was increased at a rate of 2 °C / min, and the mixture was continuously stirred at 600 rpm. When the temperature reached 90 °C, the stirring rate was increased to 1600 rpm to carry out the reaction. Samples were taken every 2 hours during the reaction, and the reaction progress was monitored by thin-layer chromatography (TCL). The developing solvent was petroleum ether-ethyl acetate (volume ratio of 5:1). The reaction was stopped when the starting material spots disappeared.

[0051] After the reaction was completed, the reaction solution was transferred to room temperature and cooled, and allowed to stand for 6 hours. The cooled reaction solution was then transferred to a rotary evaporator and initially concentrated at 30°C and a vacuum of -0.09 MPa to remove some of the solvent. Then, a nitrogen evaporator was used for precise concentration, with the nitrogen evaporation temperature set at 40°C, the nitrogen pressure at 0.1 MPa, and the purging rate at 10 mL / min, until a yellow viscous crude product was obtained. The crude product was dissolved in N,N-dimethylformamide to prepare a solution with a concentration of 10 mg / mL. The solution was then transferred into a dialysis bag with a molecular weight cutoff of 3500 Da. An ethanol-purified water mixture (volume ratio of 1:2) was used as the external dialysis solution, with the volume of the external solution being 10 times that of the internal solution. Dialysis was performed at room temperature for 24 hours, and the external solution was replaced every 8 hours. After dialysis, the solution in the bag was collected and filtered through a 0.45 μm organic phase filter membrane. The filtered solution was mixed with anhydrous ethanol-purified water (volume ratio 1:2), with a crude product to solvent ratio of 3 mg:1 mL. The mixture was allowed to stand at 1 °C for 16 h to precipitate crystals. The crystals were then filtered using medium-speed filter paper (1 layer) at a flow rate of 0.4 mL / s and a vacuum of -0.09 MPa. During filtration, the crystals were washed once with anhydrous ethanol-purified water (volume ratio 1:3) at a flow rate of 0.2 mL / s. The crystals obtained after filtration were freeze-dried at -40 °C for 36 h to obtain 314.4 g of cinnamaldehyde thymol powder, i.e., cinnamaldehyde thymol molecular gyroscope, denoted as "BNIP". The yield was calculated to be 90.2%.

[0052] Example 3

[0053] 865.28 g (4 mol) of α-hexylcinnamaldehyde was mixed with a solvent (ethanol and dimethyl sulfoxide in a volume ratio of 20:1) and stirred at 1500 rpm for 2 h at 25 °C and a nitrogen blowing rate of 20 mL / min to obtain a cinnamaldehyde derivative solution with a concentration of 4 mol / L. 150.22 g (1 mol) of natural thymol was mixed with a mixed solvent of acetone and ethyl acetate (the volume ratio of acetone and ethyl acetate was 1:1). The mixture was stirred at 1800 rpm at 25 °C and simultaneously subjected to ultrasonic oscillation at 40 kHz for 1.0 h to obtain a thymol solution with a concentration of 3 mol / L. 425.0 g (5 mol) of sodium bicarbonate and 1.0 L of anhydrous ethanol-purified water mixed solvent (volume ratio of anhydrous ethanol to purified water is 8:1) were mixed to obtain an inorganic alkali solution (concentration of 5 mol / L); then 702.9 g (6 mol) of betaine and ethyl acetate-ethanol mixed solvent (volume ratio of ethyl acetate to ethanol is 1:6) were mixed and stirred at 900 rpm for 0.9 h to prepare an organic alkali solution (concentration of 6 mol / L); then the organic alkali solution was added to the inorganic alkali solution at a spray rate of 12 mL / min, and the mixture was stirred continuously at 1800 rpm during the spraying process until the spraying was completed to obtain a composite alkaline solution; then thymol solution was added to the composite alkaline solution at a spray rate of 12 mL / min, and the temperature was raised to 50℃ during the spraying process, and the mixture was stirred continuously at 2200 rpm to obtain an alkalized thymol mixed solution; The above-mentioned cinnamaldehyde derivative solution was added to the alkalized thymol mixture at a spray rate of 25 mL / min. During the addition process, nitrogen blowing was maintained at 20 mL / min, and the temperature was increased at a rate of 5 °C / min. The mixture was stirred continuously at a speed of 1600 rpm. When the temperature reached 130 °C, the stirring rate was increased to 2500 rpm to carry out the reaction. Samples were taken every 2 hours during the reaction, and the reaction progress was monitored by thin-layer chromatography (TCL). The developing solvent was petroleum ether-ethyl acetate (volume ratio of 8:1). The reaction was stopped when the starting material spots disappeared.

[0054] After the reaction was completed, the reaction solution was transferred to room temperature and cooled, and allowed to stand for 12 hours. The cooled reaction solution was then transferred to a rotary evaporator and initially concentrated at 50°C and a vacuum of -0.07 MPa to remove some of the solvent. Then, a nitrogen evaporator was used for precise concentration, with the nitrogen evaporation temperature set at 50°C, the nitrogen pressure at 0.2 MPa, and the purging rate at 30 mL / min, until a yellow viscous crude product was obtained. The crude product was dissolved in N,N-dimethylformamide to prepare a solution with a concentration of 50 mg / mL. The solution was then transferred into a dialysis bag with a molecular weight cutoff of 8000 Da. An ethanol-purified water mixture (volume ratio of 1:8) was used as the external dialysis solution, with the volume of the external solution being 30 times that of the internal solution. Dialysis was performed at room temperature for 48 hours, and the external solution was replaced every 8 hours. After dialysis, the solution in the bag was collected and filtered through a 0.45 μm organic phase filter membrane. The filtered solution was mixed with anhydrous ethanol-purified water (volume ratio 1:4), with a crude product to solvent ratio of 7 mg:1 mL. The mixture was allowed to stand at 10 °C for 24 h to precipitate crystals. The crystals were then filtered using medium-speed filter paper (3 layers) at a flow rate of 0.8 mL / s and a vacuum of -0.07 MPa. During filtration, the crystals were washed three times with an anhydrous ethanol-purified water mixture (volume ratio 1:8) at a flow rate of 0.8 mL / s. The crystals obtained after filtration were freeze-dried at -15 °C for 54 h to obtain 317.5 g of cinnamaldehyde thymol powder, i.e., cinnamaldehyde thymol molecular gyroscope, denoted as "BNIP", with a calculated yield of 91.1%.

[0055] The schematic diagram of the mechanism of micro-area viscosity detection by the cinnamaldehyde-modified thymol molecular gyroscope obtained in Example 1 is shown below. Figure 1 As shown, this molecular gyroscope possesses a unique large-π conjugated alternating single and double bond structure, exhibiting excellent molecular flexibility and controllable rotation characteristics as its core structural advantages. Its freely rotating conjugated system within the molecule can precisely respond to changes in environmental viscosity. In low-viscosity thymol oil and its derivatives (such as compound oils, microemulsions, and gels), the conjugated structure can rotate freely mechanically, and excited-state energy is efficiently dissipated through non-radiative transitions, resulting in weak apparent light signals. However, in high-viscosity systems, molecular rotation is suppressed, and excited-state energy is mainly released through radiative transitions, significantly enhancing the light signal intensity. This unique mechanism of "rotation-controlled luminescence" allows it to directly reflect the viscosity differences of the system. Simultaneously, this molecular gyroscope is highly responsive to changes in viscosity. With a sensitivity coefficient as high as 0.65, it possesses extremely strong micro-area viscosity sensing capabilities, enabling in-situ, real-time, and precise monitoring of the modulation process of thymol oil derivatives. This effectively avoids the lag and errors of traditional detection methods, significantly improving the precision of product process control. Furthermore, it exhibits excellent chemical and light stability, maintaining structural stability in complex thymol oil systems and over a wide pH range. Even after prolonged irradiation, it maintains stable light signal output. In addition, its large Stokes shift effectively avoids excitation light interference, significantly improving the detection signal-to-noise ratio. This provides a reliable molecular tool for the quality control, process optimization, and storage stability monitoring of thymol oil derivatives, demonstrating broad application potential.

[0056] The high-resolution mass spectrum of the cinnamaldehyde-modified thymol molecular gyroscope obtained in Example 1 is shown below. Figure 2 As shown. By Figure 2 Therefore, the relative molecular mass of BNIP is 348.52946 [M]. + The molecular formula is C 25 H 32 O, whose theoretical relative mass estimate is 348.53000, means that in terms of relative molecular mass, the product obtained in Example 1 is consistent with the target product.

[0057] The nuclear magnetic resonance spectrum of the cinnamaldehyde-modified thymol molecular gyroscope obtained in Example 1 is shown below. Figure 3 As shown. By Figure 3 As can be seen, the carbon spectrum of BNIP is 13 C10 NMR (101 MHz, DMSO-d6) δ 152.4, 144.2, 135.9, 135.1, 134.8, 133.1, 130.2, 128.4, 127.9, 125.5, 124.5, 120.1, 112.1, 34.8, 33.2, 30.1, 28.5, 28.1, 23.9, 22.2, 12.9. The carbon skeleton shift in its molecular structure was confirmed, and it can be identified as the target product, cinnamaldehyde thymol.

[0058] The cinnamaldehyde-modified thymol molecular gyroscope obtained in Example 1 was subjected to the following performance tests: 1. Viscosity response test Six groups of glycerol aqueous solutions with different viscosities (glycerol volume fractions of 0%, 10%, 30%, 50%, 70%, and 99%, respectively) were prepared. Cinnamaldehyde-modified thymol molecular gyroscopes were added to each solution to obtain a 10 μM target test solution. The external excitation wavelength was controlled at 300 nm, and spectral measurements were performed at room temperature. The resulting emission spectra are shown below. Figure 4 As shown. By Figure 4 It is evident that the cinnamaldehyde-modified thymol molecular gyroscope exhibits extremely strong sensitivity to changes in the viscosity of the solution micro-region—as the viscosity of the glycerol aqueous solution gradually increases, the intensity of its emitted light signal shows a significant increasing trend. Especially when the volume fraction of glycerol exceeds 70%, the system viscosity increases dramatically, and the corresponding light signal intensity also shows an explosive increase. Compared to purified water without added glycerol, the highest light signal intensity is increased by approximately 90 times, demonstrating the cinnamaldehyde-modified thymol molecular gyroscope's sensitive detection capability for high-viscosity systems. Further analysis of the test data, such as... Figure 5 As shown, the fluorescence intensity of this molecular gyroscope can be fitted to a straight line as a logarithmic function of the solution viscosity. The fitting result is in high agreement with the Förster-Hoffmann relation, with a viscosity sensitivity coefficient as high as 0.65 and a coefficient of determination of 0.98, indicating that its response to viscosity changes has excellent linear correlation and reliability. This outstanding viscosity sensitivity makes it extremely valuable and promising for the production process of thymol oil derivatives (such as compound oils, microemulsions, gels, etc.). It can provide real-time and reliable supporting data for the precise adjustment of micro-region viscosity (thickness) of these products, helping to achieve refined control of product processes and improve quality stability, and providing a powerful molecular detection tool for the quality optimization of thymol oil derivatives.

[0059] 2. Light stability test

[0060] 1.39 mg of cinnamaldehyde-treated thymol molecular gyroscope was dissolved in a 1:5 volume ratio ethanol-purified aqueous solution to prepare a 4 mM stock solution. For testing, the solution was diluted to 10 μM with the same volume ratio of ethanol-water solution and then added to systems with different viscosities (water and glycerol). The solutions were continuously irradiated under a 300 nm excitation light source for 60 min, and the changes in light signal intensity were monitored. The test results are as follows: Figure 6 As shown. The photostability test results of the cinnamaldehyde-modified thymol molecular gyroscope obtained in Example 1 in glycerol (high viscosity system) and purified water (low viscosity system) are as follows. Figure 6 As shown. By Figure 6 As can be seen, this molecular gyroscope exhibits excellent photostability—regardless of whether in low or high viscosity systems, after continuous excitation and irradiation for up to 60 minutes, the intensity of its emitted light signal remains stable without significant attenuation. This excellent photostability, maintained under different viscosity environments, is one of its core advantages for application in thymol oil derivatives (such as compound oils, microemulsions, gels, etc.). Process control and storage stability monitoring of thymol oil derivatives often require long-term viscosity testing, and the stable light signal output of this molecular gyroscope ensures the accuracy and reliability of the test data, avoiding detection errors caused by light signal attenuation. This provides continuous and stable support for precise control of product viscosity and assurance of quality consistency, greatly enhancing its application value and potential in the research and development and production of thymol oil derivatives.

[0061] 3. pH tolerance test

[0062] 1.74 mg of the cinnamaldehyde-modified thymol molecular gyroscope prepared in Example 1 was weighed and dissolved in a mixed solution of jojoba oil and thymol oil (jojoba oil:thymol oil volume ratio of 3:1) to prepare a stock solution with a concentration of 4 mM. This stock solution was then added to a series of buffer solutions with pH values ​​ranging from 5.0 to 10.0 to achieve a final concentration of 10 μM for the cinnamaldehyde-modified thymol molecular gyroscope. The dynamic changes in its light signal intensity were measured using a fluorescence spectrometer at room temperature. The test results are as follows: Figure 7 As shown. By Figure 7It was found that the cinnamaldehyde-modified thymol molecular gyroscope exhibited stable and uniform fluorescence signal output within a wide pH range of 5.0–10.0, with a fluorescence intensity variation coefficient (RSD) of less than 3%, and no obvious signal attenuation, spikes, or fluctuations were observed, indicating its excellent pH tolerance. This characteristic stems from its unique molecular structural advantages: the large π-conjugated skeleton derived from α-hexylcinnamaldehyde works synergistically with the phenolic ether functional groups of thymol to construct a thermodynamically stable molecular configuration. The long-chain alkyl group shields the molecular active sites through steric hindrance, effectively resisting protonation attacks under acidic conditions and deprotonation in alkaline environments, ensuring that the molecule maintains structural integrity and optical performance stability over a wide pH range.

[0063] The excellent pH tolerance of the cinnamaldehyde-modified thymol molecular gyroscope provides key technical support for its use as a molecular measurement tool for the micro-area viscosity of thymol oil derivatives. The pH of natural thymol oil and its derivatives (such as compound oils, microemulsions, and gels) typically fluctuates between pH 5.0 and 10.0, influenced by factors such as raw material source, extraction process, storage conditions, and downstream compounding additives (such as acidic flavorings and weakly basic preservatives). This molecular gyroscope can operate stably within this typical application scenario's pH range, avoiding interference from pH fluctuations on the fluorescence signal and ensuring the accuracy and reproducibility of viscosity measurement results. This pH robustness significantly broadens its application scope, making it suitable not only for viscosity measurement of pure thymol oil systems but also for compound thymol oil products containing acidic / alkaline additives (such as compound oils, microemulsions, and gels). Its structural stability and consistent optical properties over a wide pH range make it highly valuable for industrial production quality control, formulation optimization, long-term stability monitoring, and downstream product development of thymol oil derivatives. It provides a highly adaptable and reliable molecular tool for precise micro-area viscosity sensing of the thymol oil system, and has broad prospects for industrial application in the intersection of fine chemicals and molecular sensing.

[0064] 4. Stokes displacement test

[0065] 2.09 mg of the cinnamaldehyde-modified thymol molecular gyroscope from Example 1 was dissolved in an ethanol-purified aqueous solution at a volume ratio of 1:5 to prepare a 6 mM stock solution. For testing, the solution was further diluted to 10 μM with the same volume ratio of ethanol-purified aqueous solution, and then added to purified water. Its absorption and emission spectra were measured at room temperature, and its Stokes shift was determined. The test results are as follows: Figure 8 As shown. By Figure 8As can be seen, the Stokes shift of this molecular gyroscope is as high as 135.6 nm. This advantage makes its emitted light and excitation light have excellent band separation, which can effectively avoid the scattering interference of excitation light and the fluorescence superposition effect of other components in the system, greatly improve the detection signal-to-noise ratio, and ensure the clarity and accuracy of optical signal detection.

[0066] The high signal-to-noise ratio characteristic brought about by the large Stokes displacement is of key value for its application in thymol oil derivatives (such as compound oils, microemulsions, gels, etc.). Thymol oil derivative systems are often complex in composition, potentially containing base oils, other plant essential oils, emulsifiers, preservatives, and other components. These components can easily generate background interference, affecting the discriminability of viscosity detection signals. However, this molecular gyroscope, with its large 135.6nm Stokes displacement, can accurately capture its own specific optical signal in complex systems, unaffected by impurities, ensuring the reliability of micro-area viscosity detection data. This advantage makes it suitable for the entire process of thymol oil derivative product applications, from production process control (such as viscosity adjustment) and finished product quality testing to long-term storage stability monitoring. It provides precise data support for refined optimization of product processes and quality consistency control, significantly expanding its application scenarios and potential in thymol oil-related fine chemicals, daily chemicals, and pharmaceuticals, becoming a high-quality molecular tool with both anti-interference capabilities and detection accuracy in the field of viscosity sensing for such products.

[0067] Application Example 1

[0068] 2.44 mg of the cinnamaldehyde-modified thymol molecular gyroscope from Example 1 was dissolved in a purified water-ethanol solution with a volume ratio of 4:1 to prepare a 4 mM stock solution. For testing, the solution was diluted to 10 μM with the same volume ratio of purified water-ethanol solution. Three commercially available thymol oil derivatives were selected as test subjects: thymol compound oil (Plant Therapy), thymol microemulsion (Hengcheng Chemical), and thymol soothing gel (Mentholatum). The 10 μM molecular gyroscope solution was added to each of these three products, and the test was conducted at room temperature with an external excitation wavelength of 300 nm. The test results are as follows: Figure 9 As shown. By Figure 9It can be seen that there are significant differences in the light signal emission intensity of the three products, indicating that their micro-region viscosity is different. This is directly related to the type and composition of the products—different component ratios will significantly affect the flow characteristics, skin adhesion, moisturizing effect, and user experience of thymol oil derivatives. Specifically, the thymol compound oil has the weakest light signal intensity, belonging to a low-viscosity product. It has a relatively thin overall appearance, good fluidity, and is easy to apply and absorb. The thymol microemulsion has a medium light signal intensity, corresponding to a medium viscosity, and has both good adhesion and moisturizing effect, resulting in a balanced user experience. The thymol soothing gel has the strongest light signal intensity, belonging to a high-viscosity product. It has excellent viscosity, good shaping properties, and can stay on the skin surface for a long time, resulting in a more lasting nourishing effect. The test results fully demonstrate that the cinnamaldehyde thymol molecular gyroscope can accurately sense the micro-region viscosity changes of commercially available thymol oil derivatives and present them intuitively through visual light signals. This has important guiding significance for the optimization of thickening processes and formula iteration of thymol oil derivatives, and can help companies develop products that meet different usage scenarios (such as fast-absorbing and long-lasting nourishing types) and customer needs, significantly enhancing its application value and market potential in thymol oil-related daily chemical, skin care, and health care fields.

[0069] As can be seen from the above embodiments, the cinnamaldehyde-modified thymol molecular gyroscope provided by the present invention uses thymol oil and natural thymol as key raw materials, and constructs a flexible large π-type gyroscope through natural product modification. The conjugated structure allows for dynamic control of molecular rotation, converting micro-viscosity differences in thymol oil derivatives into highly visually sensitive blue light signals. This enables precise and visual detection of viscosity indicators at the molecular level. Various test results fully validate its superior comprehensive performance. It not only possesses excellent photostability, maintaining stable light signal output without significant attenuation even after prolonged continuous excitation irradiation, but also boasts a viscosity sensitivity coefficient as high as 0.65. It can accurately capture micro-viscosity changes in commercially available products such as thymol compound oil (low viscosity), thymol microemulsion (medium viscosity), and thymol soothing gel (high viscosity), clearly distinguishing different viscosity grades through differences in light signal intensity. This makes it suitable for the complex component systems of these products. Furthermore, its Stokes shift exceeds 135 nm, effectively avoiding excitation light scattering and background interference from other components in the product, significantly improving the signal-to-noise ratio and ensuring the accuracy and reproducibility of viscosity detection data under complex environments. This molecular gyroscope also offers significant advantages in its fabrication, employing a one-step process. Synthesized from natural raw materials, with thymol from thymol oil as the core, this molecular gyroscope is inexpensive, readily available, and requires no complex procedures. Post-processing is simple and easy, resulting in a high yield. Application requires only milligram-level dosage, making it low-carbon, environmentally friendly, and cost-controllable. It is perfectly suited for large-scale industrial production and application. Its practical application value can be fully realized in various commercially available thymol oil derivatives. It can serve as an in-situ viscosity detection tool to track viscosity changes during product production, blending, and storage, providing precise data support for thickening process optimization and formula iteration. Furthermore, its visualized optical signal advantage provides a new path for product stability monitoring, enhancing its multiple practical functions. In summary, this cinnamaldehyde-modified thymol molecular gyroscope, with its excellent spectral performance, high viscosity sensitivity, strong anti-interference ability, and environmentally friendly preparation advantages, demonstrates extremely high application value and broad prospects in the quality control, process upgrading, and scenario-based formula development of thymol oil derivatives, providing a reliable molecular-level tool for the refined production and quality improvement of these products.

[0070] The above description is only a preferred embodiment of the present invention. It should be noted that for those skilled in the art, several improvements and modifications can be made without departing from the principle of the present invention, and these improvements and modifications should also be considered within the scope of protection of the present invention.

Claims

1. A cinnamaldehyde-modified thymol molecular gyroscope, characterized in that, The structure of the cinnamon-aldehyde-modified thymol molecular gyroscope is shown in Formula I: Formula I.

2. The method for preparing the cinnamaldehyde-modified thymol molecular gyroscope according to claim 1, characterized in that, The process includes the following steps: mixing a thymol solution and a composite alkaline solution, adding a cinnamaldehyde derivative solution to react, and obtaining a cinnamaldehyde-modified thymol molecular gyroscope.

3. The method for preparing the cinnamaldehyde-modified thymol molecular gyroscope according to claim 2, characterized in that, The concentration of the thymol solution is 1-3 mol / L; the solvent of the thymol solution is one or more of acetone, butanone, ethyl acetate, tetrahydrofuran, 1,4-dioxane, N,N-dimethylformamide, acetonitrile, and dimethyl sulfoxide.

4. The method for preparing the cinnamaldehyde-modified thymol molecular gyroscope according to claim 2 or 3, characterized in that, The composite alkaline solution is prepared by mixing an inorganic alkaline solution and an organic alkaline solution.

5. The method for preparing the cinnamaldehyde-modified thymol molecular gyroscope according to claim 4, characterized in that, The inorganic base in the inorganic base solution includes one or more of sodium carbonate, sodium bicarbonate, and cesium carbonate; the solvent of the inorganic base solution is a mixed solvent of alcohol and water; the concentration of the inorganic base solution is 1~5 mol / L.

6. The method for preparing the cinnamaldehyde-modified thymol molecular gyroscope according to claim 5, characterized in that, The organic base in the organic base solution includes one or more of piperidine, betaine, choline, and quinoline; the solvent of the organic base solution is a mixture of a first solvent and a second solvent, wherein the first solvent includes ethyl acetate, tetrahydrofuran, 1,4-dioxane, N,N-dimethylformamide, or acetonitrile, and the second solvent is ethanol; the volume ratio of the first solvent to the second solvent is 1~8:1; and the concentration of the organic base solution is 1~6 mol / L.

7. The method for preparing the cinnamaldehyde-modified thymol molecular gyroscope according to claim 5 or 6, characterized in that, The cinnamaldehyde derivative in the cinnamaldehyde derivative solution is α-hexylcinnamaldehyde, and the solvent is a mixture of alcohol and dimethyl sulfoxide; the concentration of the cinnamaldehyde derivative solution is 1~4 mol / L.

8. The method for preparing the cinnamaldehyde-modified thymol molecular gyroscope according to claim 7, characterized in that, The molar ratio of thymol, cinnamaldehyde derivative, inorganic base and organic base is 1~3:1~4:1~5:1~6.

9. The method for preparing the cinnamaldehyde-modified thymol molecular gyroscope according to claim 3, 6, or 8, characterized in that, The reaction temperature is 90~130℃, and the reaction progress is monitored by thin-layer chromatography during the reaction.

10. The application of the cinnamaldehyde-modified thymol molecular gyroscope according to claim 1 in the monitoring or detection of the physical microenvironment viscosity of thymol oil derivatives.

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