Anti-tumor natural pharmaceutical composition based on acer norvegensis and preparation method of anti-tumor natural pharmaceutical composition

By extracting triterpenoid saponins of the genus Acer from the bark of the Norwegian maple, the problems of poor water solubility and drug resistance of existing natural antitumor drugs have been solved, achieving selective inhibition and apoptosis induction of various tumor cells, which has broad prospects for pharmaceutical applications.

CN122325530APending Publication Date: 2026-07-03QUJING NORMAL UNIV
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Patent Information

Application Number
CN202610438825.4
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-04-03
Publication Date
2026-07-03

AI Technical Summary

Technical Problem

Existing natural anti-tumor drugs such as paclitaxel and doxorubicin have problems in clinical application, including poor water solubility, significant toxic side effects, and easy development of drug resistance.

Method used

Triterpenoid saponins of the cymene type were extracted and isolated from the bark of Acer platanoides. An antitumor natural drug composition was prepared by a combination of liquid-liquid extraction, resin column chromatography, gel column chromatography and reversed-phase ODS column chromatography.

Benefits of technology

This study enriches the chemical composition library of Acer species. The compounds exhibit selective cytotoxicity against various tumor cells, particularly melanoma, renal cell carcinoma, breast cancer, and liver cancer cells. They also induce tumor cell apoptosis by regulating the PI3K/Akt/mTOR signaling pathway, demonstrating good structural novelty and drug-like properties.

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Abstract

The invention discloses an anti-tumor natural pharmaceutical composition based on acer norvegensis and a preparation method, and relates to the technical field of biological medicines. The compound is selected from at least one of the following structures: 3-O-[beta-D-glucopyranosyl-(1-> 4)-[beta-D-galactopyranosyl-(1-> 2)]-[beta-D-glucopyranosyl]-[beta]-D-glucopyranuronid-21-O-acetyl-22-O-angeloyl choylonol, and the molecular formula of the compound is C55H86O23. According to the invention, the triterpenoid saponin compound with the stamen-verbascol skeleton is separated from the bark of the acer norvegensis, so that the chemical component library of acer plants is enriched. The structure of the compound simultaneously contains a unique oligosaccharide chain and C-21 and C-22 diacyl substitution modes, the C-21 site of one compound is connected with a rare branched acyl (3-hydroxy-4-methyl hexanoyl), the C-3 site trisaccharide chain of the other compound contains an arabinofuranose unit, and the structural characteristics are rare in natural products, so that the compound can be widely applied to the field of natural products. And good structural novelty is achieved.
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