A method for homogeneously preparing succinic anhydride-modified agarose
By using EDC·DMAP catalyst in a homogeneous DMF solution system for low-temperature esterification, the problems of uneven reaction and low crosslinking degree in heterogeneous modification processes were solved, and modified agarose with high crosslinking degree, high hydrophilicity, and high gel strength was prepared, which is suitable for biomedicine, tissue engineering and other fields.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- JIMEI UNIV
- Filing Date
- 2026-05-11
- Publication Date
- 2026-07-17
AI Technical Summary
Existing heterogeneous modification processes result in uneven reactions, low cross-linking degree, and poor mechanical properties in succinic anhydride-modified agarose, making it difficult to achieve agarose materials with high cross-linking degree, high hydrophilicity, and high gel strength.
A modified agarose with high cross-linking degree, high hydrophilicity, and high gel strength was prepared by using a DMF homogeneous dissolution system and EDC·DMAP composite catalyst under low temperature conditions and controlling the reaction time and succinic anhydride feed amount.
Uniform esterification and controllable cross-linking of agarose were achieved, resulting in a product with high cross-linking degree, dense structure, excellent hydrophilicity, significantly improved gel strength, good performance stability and repeatability, and suitability for large-scale production.
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Figure CN122404594A_ABST