Composition for treating chronic gastritis and application thereof

By regulating the PI3K/AKT/P53 signaling pathway and autophagy pathway through the traditional Chinese medicine composition "Xiaoliu Zhiwei Fang", the reversal of chronic atrophic gastritis and precancerous lesions was solved, achieving the effects of improving gastric mucosal function and reducing the risk of gastric cancer, providing a new method for the treatment of CAG with traditional Chinese medicine.

CN122440779APending Publication Date: 2026-07-24AFFILIATED HOSPITAL OF JIANGXI UNIV OF TCM
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Patent Information

Application Number
CN202610721800.5
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-05-25
Publication Date
2026-07-24

AI Technical Summary

Technical Problem

Current technologies lack effective interventions to reverse chronic atrophic gastritis (CAG) and precancerous lesions, especially intestinal metaplasia, which leads to a high risk of gastric cancer, and there is a lack of specific therapies targeting the "inflammation-cancer" transformation of the stomach.

Method used

A traditional Chinese medicine composition, "Xiaoliu Zhiwei Fang" (Eliminating Tumors and Treating Atrophy), is provided, consisting of Pinellia ternata, Scutellaria baicalensis, Coptis chinensis, Zingiber officinale, Codonopsis pilosula, Hedyotis diffusa, Scutellaria barbata, Curcuma zedoaria, Citrus aurantium (fried), Hordeum vulgare (fried), Hordeum vulgare (fried), Curcuma longa, Panax notoginseng, Ziziphus jujuba, and Glycyrrhiza uralensis (processed). It works by regulating the PI3K/AKT/P53 signaling pathway and autophagy-related pathways, synergistically anti-inflammatory and anti-aging effects, improving gastric mucosal function, and reversing the progression of CAG.

Benefits of technology

It significantly improves gastric mucosal atrophy and intestinal metaplasia, inhibits the activation of autophagy by the P53 pathway, blocks the "inflammation-cancer" transformation of CAG, and reduces the risk of gastric cancer. This aligns with the TCM diagnostic and treatment philosophy of "preventing disease before it occurs and preventing its progression once it has occurred," and provides a new approach to TCM treatment of CAG.

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Abstract

The invention relates to the field of traditional Chinese medicines, in particular to a composition for treating chronic gastritis and application of the composition. The traditional Chinese medicine composition is prepared from 8-12 parts of rhizoma pinellinae praeparata, 8-12 parts of scutellaria baicalensis, 3-7 parts of coptis chinensis, 4-8 parts of dried ginger, 12-18 parts of radix pseudostellariae, 12-18 parts of oldenlandia diffusa, 12-16 parts of sculellaria barbata, 8-12 parts of curcuma zedoary, 12-20 parts of fried fructus aurantii, 18-22 parts of fried rice sprouts, 18-22 parts of fried malt, 8-12 parts of radix curcumae, 1-5 parts of pseudo-ginseng, 8-12 parts of Chinese dates and 3-8 parts of honey-fried licorice roots. The invention effectively solves the problems of lack of specific therapy and specific intervention targets for reversing precancerous lesions such as mucous membrane atrophy, intestinal metaplasia and the like in the prior art, provides a new thought for mechanism research on traditional Chinese medicine treatment of CAG, and has important theoretical value and clinical transformation prospect for promoting modernization of traditional Chinese medicine.
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