Laboratory modeling and poisoning device for disturbance of consciousness after hypoxic-ischemic encephalopathy

Abstract

The utility model discloses a laboratory device for modeling and poisoning disturbance of consciousness after hypoxic-ischemic encephalopathy, which comprises a gas storage module, a collecting bottle and an injector assembly, and the gas storage module is communicated with the collecting bottle through a first conveying pipeline; the syringe assembly comprises a syringe body, a multi-channel connector and a needle, the multi-channel connector comprises a communicating vessel body, a switching valve, a first connecting end, a second connecting end and a third connecting end, the switching valve, the first connecting end, the second connecting end and the third connecting end are arranged on the communicating vessel body, and the communicating vessel body is connected with a needle connecting part of the syringe body through the first connecting end. The second connecting end of the communicating vessel main body is communicated with the collecting bottle through the second conveying pipeline, and the needle head is mounted on the third connecting end; when the switching valve is located at the first position, the first connecting end is communicated with the second connecting end so as to supply carbon monoxide into the injector body, and when the switching valve is located at the second position, the first connecting end is communicated with the third connecting end. The device has the advantages of simplicity and convenience in operation and high practicability.

Description

Technical Field

[0001] The utility model relates to a field, in particular to a modeling and poisoning device for post-ischemic hypoxic encephalopathy-induced disturbance of consciousness in a laboratory. Background Technique

[0002] Carbon monoxide is a common gas, and its high-concentration exposure may cause serious harm to human health. At present, many related majors such as universities and scientific research institutions need to produce carbon monoxide (CO) to conduct scientific research on experimental animals such as mice.

[0003] In the prior art, the commonly used method is to carry out a chemical reaction between formic acid and concentrated sulfuric acid in a glassware to generate carbon monoxide gas. The generated carbon monoxide gas first flows through an acidic impurity absorbent composed of sodium hydroxide solution to absorb acidic gas impurities doped in the carbon monoxide gas, and then flows through a desiccant to absorb water vapor impurities doped in the carbon monoxide gas. Finally, the carbon monoxide gas with higher purity is transported to a mouse breeding cage (poisoning chamber).

[0004] In some experimental research processes, it is necessary to take the method of intraperitoneal injection for poisoning operation instead of inhalation poisoning. For example, in the quantitative intraperitoneal injection method poisoning experiment; currently, the common operation is that the operator directly connects a carbon monoxide gas cylinder to the poisoning box through a hose for inhalation poisoning. This operation has the risk of carbon monoxide leakage and impure concentration after gas dilution, and it is easy to have operation errors or even accidents, increasing the danger of the experiment and reducing the accuracy of the test. Content of the Utility Model

[0005] In order to solve the deficiencies in the prior art, the main purpose of the utility model is to provide a modeling and poisoning device for post-ischemic hypoxic encephalopathy-induced disturbance of consciousness in a laboratory with simple operation and strong practicability.

[0006] To achieve the above main purpose, the utility model discloses a modeling and poisoning device for post-ischemic-hypoxic encephalopathy consciousness disorder in the laboratory, which includes a gas storage module, a collection bottle and a syringe assembly. The gas storage module and the collection bottle are connected through a first delivery pipeline to supply carbon monoxide in the gas storage module to the collection bottle. The collection bottle first collects gas by the water displacement method and then inputs the gas into the syringe by the exhaust method. The syringe assembly includes a syringe body, a multi-way connector and a detachable needle. The multi-way connector includes a connector body and a switching valve, a first connection end, a second connection end and a third connection end arranged on the connector body. The connector body is connected to the needle connection part of the syringe body through the first connection end. The second connection end of the connector body is connected to the collection bottle through a second delivery pipeline to receive the carbon monoxide supplied from the collection bottle. The needle is installed on the third connection end. Among them, when the switching valve is in the first position, the first connection end is connected to the second connection end to supply carbon monoxide into the syringe body. When the switching valve is in the second position, the first connection end is connected to the third connection end to discharge the carbon monoxide in the syringe body through the needle.

[0007] According to a specific embodiment of the present invention, the second delivery pipeline is a flexible hose.

[0008] According to a specific embodiment of the present invention, the first connection end and the third connection end are collinearly arranged along the length direction of the syringe body.

[0009] According to a specific embodiment of the present invention, the needle is inserted and matched with the third connection end.

[0010] According to a specific embodiment of the present invention, a protective sleeve adapted to the third connection end is arranged on the connector body, and the needle is inserted into the inside of the protective sleeve.

[0011] According to a specific embodiment of the present invention, the needle is threadedly connected to the protective sleeve.

[0012] According to a specific embodiment of the present invention, control valves are arranged on both the first delivery pipeline and the second delivery pipeline.

[0013] According to a specific embodiment of the present invention, scale lines are arranged on the syringe body.

[0014] According to a specific embodiment of the present invention, the collection bottle is cylindrical.

[0015] The utility model has the following beneficial effects: It provides a modeling and poisoning device for post-ischemic-hypoxic encephalopathy with disturbance of consciousness applicable to quantitative intraperitoneal injection poisoning experiments in the laboratory. It collects carbon monoxide through a collection bottle, and transports the carbon monoxide in the collection bottle to a syringe assembly through a second delivery pipeline and a control valve for use. Among them, the syringe assembly includes a multi-path connector provided with a switching valve, and the switching valve is used to inject carbon monoxide into the syringe body and discharge the carbon monoxide in the syringe body outward. The above operations can be completed without manually operating the syringe body, which has the advantages of simple operation and strong practicability.

[0016] In addition, the second delivery pipeline is specifically a flexible hose. During intraperitoneal injection operations, the second delivery pipeline can undergo adaptive deformation without being disassembled from the second connection end of the connector body, which is beneficial to maintaining the sealing performance.

[0017] In order to more clearly illustrate the purpose, technical solution, and advantages of the present utility model, the present utility model will be further described in detail below with reference to the accompanying drawings and specific embodiments. Description of the Drawings

[0018] Figure 1 is the first connection schematic diagram of the device embodiment of the present utility model;

[0019] Figure 2 is the second connection schematic diagram of the device embodiment of the present utility model;

[0020] Figure 3 is the schematic diagram of the collection bottle in the device embodiment of the present utility model;

[0021] Figure 4 is the perspective view of the syringe assembly in the device embodiment of the present utility model;

[0022] Figure 5 is the exploded view of the syringe assembly in the device embodiment of the present utility model;

[0023] Figure 6 is the structural diagram of the multi-path connector in the device embodiment of the present utility model. Detailed Embodiments

[0024] In the following description, many specific details are set forth in combination with the embodiments to fully understand the present utility model. However, it should be understood that the following embodiments and detailed descriptions are only for illustrative purposes and do not limit the protection scope of the present utility model.

[0025] The modeling and poisoning device for post-ischemic-hypoxic encephalopathy with disturbance of consciousness in the laboratory of the embodiment of the present utility model is specifically an intraperitoneal injection poisoning experiment device, as Figure 1-2As shown in the figure, it includes a gas storage module 10, a collection bottle 20 and a syringe assembly 30. Among them, the gas storage module 10 can refer to the relevant gas storage structures for chemically producing carbon monoxide in the prior art, or existing gas storage cylinders or gas storage tanks, etc. Here, it is not limited thereto and will not be elaborated. Specifically, the gas storage module 10 and the collection bottle 20 are connected and communicated through a first delivery pipeline 40 to supply the carbon monoxide generated in the gas storage module 10 to the collection bottle 20, and the collection bottle 20 and the syringe assembly 30 are connected and communicated through a second delivery pipeline 50 to supply the carbon monoxide in the collection bottle 20 to the syringe assembly 30. Among them, the first delivery pipeline 40 and the second delivery pipeline 50 are flexible hoses, which is convenient for connection and use.

[0026] The collection bottle 20 is used as an intermediate buffer tank that can provide a quantitative amount of carbon monoxide gas. Its capacity is preferably 400 ml. On the one hand, it can prevent gas overflow due to too low a capacity, and on the other hand, it can avoid waste due to too high a capacity. Specifically, water is stored in the collection tank 20. Each experiment can quantitatively collect a certain volume of carbon monoxide gas through the collection tank 20 using the downward water displacement method according to the experimental requirements. Among them, on the outer wall of the collection tank 20, a capacity mark such as a scale is preferably provided, so that the amount of carbon monoxide can be judged according to the remaining amount of water inside. An exemplary process of the downward water displacement method is as follows: 1) First, fill the collection tank 20 with water; 2) The carbon monoxide gas collected by the downward water displacement method is on the upper layer of the collection tank 20; 3) After obtaining a quantitative amount of carbon monoxide gas in the collection tank 20 as needed, stop inputting carbon monoxide gas into the collection tank 20.

[0027] As Figure 3 shown, the collection bottle 20 in the embodiment is preferably cylindrical, and is provided with a first interface portion 21 located below and a second interface portion 22 located above. Please refer to Figure 1-2, the first interface part 21 is connected to the first delivery pipeline 40, and the second interface part 22 is connected to the second delivery pipeline 50; wherein a first control valve 41 is provided at the first interface part 21, and a second control valve 51 is provided at the second interface part 22, and the on-off control of the first delivery pipeline 40 and the second delivery pipeline 50 is realized by automatically or manually controlling the first control valve 41 and the second control valve 51. Further, the second control valve 51 is specifically a three-way valve, on which a drain pipe 23 is connected, and the drain pipe 23 is used for when the collection tank 20 adopts the downward drainage method to quantitatively take carbon monoxide gas, the second control valve 51 switches to the drain pipe 23 and is connected to the collection tank 20, and passively drains water outward through the drain pipe 24. In other embodiments, the control valve 23 can also be set at other positions on the first delivery pipeline 40 and the second delivery pipeline 50, such as the middle part, which will not be expanded here. In the embodiment, the first delivery pipeline 40 and the second delivery pipeline 50 are preferably hoses, wherein the second delivery pipeline 50 preferably has a longer length, which can be convenient for connection and use.

[0028] Furthermore, the collecting bottle 20 is provided with a removable top cover 24, and the top cover 24 is preferably provided with a rubber anti-skid layer to facilitate the removal of the top cover 24 when needed.

[0029] like Figure 4-5 As shown, the syringe assembly 30 includes a syringe body 31, a multi-channel connector 32 and a detachable needle 33; wherein the syringe body 31 includes a syringe barrel 311 and a needle handle 312, and a scale line 313 is provided on the syringe barrel 311 along its length direction, which is convenient for observing whether the air pressure inside the loop is consistent with the atmospheric pressure, and on the other hand, it can avoid the formation of negative pressure causing air mixing during unloading and avoid the formation of positive pressure causing environmental pollution during unloading, and it can also facilitate the observation of the injection volume during intraperitoneal injection. Preferably, the piston on the needle handle 312 is preferably a low-resistance piston to make the movement smoother.

[0030] like Figure 6As shown in the figure, the multi-channel connector 32 includes a connector body 321, and a switching valve 322, a first connection end 323, a second connection end 324, and a third connection end 325 provided on the connector body 321. The connector body 321 is connected to the needle connection part 314 of the syringe body 31 through the first connection end 323. The second connection end 324 of the connector body 321 is communicated with the collection bottle 20 through the second delivery pipeline 50 to receive carbon monoxide supplied from the collection bottle 20. The needle 33 is installed on the third connection end 325 and is specifically inserted and matched with the third connection end 325. Among them, when the switching valve 322 is in the first position, the first connection end 323 is communicated with the second connection end 324 to supply carbon monoxide into the syringe body 31. When the switching valve 322 is in the second position, the first connection end 323 is communicated with the third connection end 325 to discharge the carbon monoxide in the syringe body 31 through the needle.

[0031] Furthermore, the first connection end 323 and the third connection end 325 are collinearly arranged along the length direction of the syringe body 31, so that the needle maintains its original use direction, which is beneficial to the operation. Among them, a protective sleeve 326 adapted to the third connection end 325 is also provided on the connector body 321, and the needle 33 is inserted into the inside of the protective sleeve 326. Preferably, the needle 33 is threadedly connected to the protective sleeve 326 to effectively maintain the connection effectiveness between the needle 33 and the third connection end 325.

[0032] Although the present invention has been depicted through embodiments above, the above embodiments are only used to exemplarily describe the feasible implementation schemes of the present invention, rather than to limit the protection scope of the present invention. Any equivalent replacement or change made by those skilled in the art in accordance with the present invention should also be covered by the protection scope defined by the claims of the present invention.

Claims

1. An ischemic and hypoxic encephalopathy-induced disturbance of consciousness modeling and poisoning device for laboratory use, characterized in that, It includes a gas storage module, a collection bottle and a syringe assembly. The gas storage module and the collection bottle are connected through a first delivery pipeline to supply carbon monoxide in the gas storage module to the collection bottle. The syringe assembly includes a syringe body, a multi-channel connector and a detachable needle. The multi-channel connector includes a connector body, a switching valve, a first connection end, a second connection end and a third connection end provided on the connector body. The connector body is connected to the needle connection part of the syringe body through the first connection end. The second connection end of the connector body is connected to the collection bottle through a second delivery pipeline to receive the carbon monoxide supplied from the collection bottle. The needle is installed on the third connection end. Wherein, when the switching valve is in the first position, the first connection end is connected to the second connection end to supply carbon monoxide to the syringe body. When the switching valve is in the second position, the first connection end is connected to the third connection end to discharge the carbon monoxide in the syringe body through the needle.

2. The ischemic and hypoxic encephalopathy-induced disturbance of consciousness modeling and poisoning device for laboratory use according to claim 1, characterized in that: The second delivery pipeline is a flexible hose.

3. The ischemic and hypoxic encephalopathy-induced disturbance of consciousness modeling and poisoning device for laboratory use according to claim 1, characterized in that: The first connection end and the third connection end are collinearly arranged along the length direction of the syringe body.

4. The ischemic and hypoxic encephalopathy-induced disturbance of consciousness modeling and drug administration device for laboratory use according to claim 1, characterized in that: The needle is inserted and matched with the third connection end.

5. The ischemic and hypoxic encephalopathy-induced consciousness disorder modeling and poisoning device for laboratory use according to claim 4, characterized in that: A protective sleeve adapted to the third connection end is provided on the connector body, and the needle is inserted into the interior of the protective sleeve.

6. The ischemic and hypoxic encephalopathy-induced consciousness disorder modeling and poisoning device for laboratory use according to claim 5, wherein: The needle is threadedly connected to the protective sleeve.

7. The ischemic and hypoxic encephalopathy-induced disturbance of consciousness modeling and poisoning device for laboratory use according to claim 1, characterized in that: Control valves are provided on both the first delivery pipeline and the second delivery pipeline.

8. The ischemic and hypoxic encephalopathy-induced disturbance of consciousness modeling and poisoning device for laboratory use according to claim 1, characterized in that: Scale lines are provided on the syringe body.

9. The ischemic and hypoxic encephalopathy-induced post-conscious disorder modeling and poisoning device for laboratory use according to claim 1, characterized in that: The collection bottle is cylindrical.

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