Method and system for improving the signal-to-noise ratio in a DNA methylation partition assay.
JP2026095541APending Publication Date: 2026-06-11GUARDANT HEALTH INC
Patent Information
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- GUARDANT HEALTH INC
- Filing Date
- 2026-03-30
- Publication Date
- 2026-06-11
AI Technical Summary
Benefits of technology
【0073】 本開示の追加の態様および利点は、本開示の単なる例証的な実施形態が示され、説明される以下の詳細な説明から当業者に容易に明らかとなるであろう。認識されるように、本開示は、他のおよび異なる実施形態が可能であり、そのいくつかの詳細は、全て本開示から逸脱することなく様々な明白な点で改変することが可能である。したがって、図面および説明は、本質的に例証的であり、限定的ではないとみなされるべきである。
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Abstract
A method for improving the signal-to-noise ratio in a DNA methylation partition assay is provided. [Solution] The present disclosure provides a method for determining the methylation status, comprising the steps of: providing a biological sample of nucleic acid molecules; distributing at least one subset of nucleic acid molecules in the biological sample into a plurality of distribution sets based on the methylation status of the nucleic acid molecules; digesting at least one subset of one or more of the plurality of distribution sets with at least one methylation-sensitive restriction enzyme; enriching at least one subset of nucleic acid molecules in the plurality of distribution sets with respect to a genomic region of interest, wherein at least one subset of nucleic acid molecules includes nucleic acid molecules digested in one or more distribution sets; and determining the methylation status of nucleic acid molecules in at least one of the distribution sets at one or more loci.
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Claims
[Claim 1] The invention described in the specification.