Barrier function enhancing agent and transepithelial electrical resistance increasing agent

The use of green tea, matcha, coix seed, rice ferment, and glycyrrhizic acid derivatives enhances epithelial tissue barrier function and resistance, addressing impaired tight junctions and histamine-induced issues, thereby preventing or treating associated diseases.

JP2026096961APending Publication Date: 2026-06-15MARUZEN PHARMA
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Patent Information

Application Number
JP2025219054
Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
Priority Date
2024-12-03
Filing Date
2025-12-02
Publication Date
2026-06-15

AI Technical Summary

Technical Problem

Existing technologies fail to effectively enhance the barrier function and transepithelial electrical resistance in epithelial tissues, leading to conditions such as inflammatory bowel disease, skin disorders, and infectious diseases due to impaired tight junction function and histamine-induced impairment.

Method used

A barrier function enhancing agent and transepithelial electrical resistance increasing agent containing green tea extract, matcha extract, coix seed extract, rice ferment, and/or glycyrrhizic acid and/or its derivatives are used to improve the barrier function and electrical resistance.

Benefits of technology

The agents significantly enhance barrier function and transepithelial electrical resistance, effectively preventing or improving conditions like inflammatory bowel disease, skin disorders, and infectious diseases by restoring the epithelial tissue barrier.

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Abstract

The present invention provides a barrier function enhancer and a transepithelial electrical resistance increasing agent, both containing active ingredients that enhance barrier function or increase transepithelial electrical resistance. [Solution] The barrier function enhancing agent and transepithelial electrical resistance increasing agent contains at least one selected from the group consisting of green tea extract, matcha extract, coix seed extract, and rice ferment, or at least one selected from the group consisting of green tea extract, matcha extract, coix seed extract, and rice ferment, and glycyrrhizic acid and / or a derivative of glycyrrhizic acid as active ingredients.
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