Drug injection device and method

Abstract

A drug infusion device according to the present invention includes a drug injector that electrochemically drives an electroosmotic pump to inhale a drug from a drug reservoir and discharge the inhaled drug into an infusion target, and a controller that outputs a control signal to the drug injector corresponding to a volume-based infusion sequence that drives the electroosmotic pump in an immediate infusion mode, the volume-based infusion sequence including at least one pulse block that defines voltage pulses or current pulses to be applied to the electroosmotic pump, each pulse block defining a pair of pulse signals that include a forward pulse and a reverse pulse that are applied to the electroosmotic pump and generate alternating negative and positive pressures, and the electroosmotic pump generates alternating negative and positive pressures for each pulse block to inhale and discharge the drug.

Description

[Technical Field]

[0001] The present invention relates to a drug infusion device and method. [Background technology]

[0002] Drugs can be injected into the body in various ways, such as orally, subcutaneously, or intravenously, depending on the type, purpose, and method of treatment. Drug injectors using drug pumps can automatically inject drugs into the body at a desired rate and volume at a required time. Therefore, drug injectors using drug pumps can be used in a variety of ways, not only in hospitals and in patients' daily lives.

[0003] Insulin pumps, commonly known as insulin injectors, are medical devices for diabetics who do not secrete insulin or who secrete only small amounts of insulin. They act like the pancreas, supplying insulin to the body from the outside at precise times to regulate blood sugar levels.

[0004] Such insulin pumps are used by insulin-dependent diabetics and can inject medication continuously 24 hours a day while worn by the patient. Because insulin injectors must inject medication into diabetics regularly over a long period of time, active technological development is underway to miniaturize and automate insulin injectors for user convenience.

[0005] Insulin injectors generally operate in a basal infusion mode, injecting medication into the user for a set period of time to maintain a constant blood glucose level, and the basal infusion mode is set based on the user's usual activity level. However, this mode has the drawback of not being able to dynamically adjust insulin injection in response to changes in blood glucose levels, such as when eating a meal or snack.

[0006] These drawbacks can cause a sudden rise in the user's blood sugar level. Therefore, there is a need for a method to continuously inject drugs into a patient while stably injecting an accurate amount of drug according to the patient's activity level and controlling the drug injection so that the drug injection channel does not become clogged. Summary of the Invention [Problem to be solved by the invention]

[0007] SUMMARY OF THE INVENTION In order to solve the above-mentioned problems, the technical object of the present invention is to provide a drug infusion method for a meal infusion mode from an electroosmotic pump-based drug infusion device.

[0008] However, the technical problem that this embodiment aims to achieve is not limited to the above-mentioned technical problem, and other technical problems may exist. [Means for solving the problem]

[0009] As a technical means for solving the above-mentioned technical problems, one embodiment of the present invention provides a drug injection device that includes a drug injector that electrochemically drives an electroosmotic pump to inhale a drug from a drug reservoir and discharge the inhaled drug into an injection target, and a controller that outputs a control signal to the drug injector corresponding to an injection sequence determined according to an injection mode, wherein the controller outputs a control signal corresponding to a volume-based injection sequence for an immediate meal injection mode or a rate-based injection sequence for an extended meal injection mode, and the electroosmotic pump alternately generates negative and positive pressure in response to the control signal to inhale and discharge the drug.

[0010] Furthermore, a drug infusion method according to one embodiment of the present invention includes the steps of setting a control signal corresponding to a volume-based infusion sequence for a meal-prompt infusion mode or setting a control signal corresponding to a rate-based infusion sequence for a meal-extended infusion mode, applying the control signal to the electroosmotic pump, and, in response to the control signal, causing the electroosmotic pump to alternately generate negative and positive pressure for each pulse block to inhale and expel the drug, wherein the electroosmotic pump alternately generates negative and positive pressure in response to the control signal to inhale and expel the drug. [Effects of the Invention]

[0011] According to the above-described means for solving the problems of the present invention, by setting one or more of a quantity-based injection sequence and a rate-based injection sequence according to the drug injection conditions for a drug injector that uses an electroosmotic pump, the drug injector can be controlled to inject a fixed amount of drug.

[0012] In addition, while the basal infusion mode is operating, the meal infusion mode can be applied to accommodate changes in blood glucose levels due to meals, allowing the user to inject a specified drug without any downtime, thereby responding to changes in the user's blood glucose levels. [Brief explanation of the drawings]

[0013] [Figure 1] FIG. 1 is a block diagram that schematically illustrates a drug injection device according to one embodiment of the present invention. [Figure 2] FIG. 2 is a block diagram showing a schematic configuration of the drug injector shown in FIG. [Figure 3] FIG. 3 is a conceptual diagram that outlines a volume-based injection sequence in accordance with one embodiment of the present invention. [Figure 4] FIG. 4 is a table illustrating an example of multiple pulse blocks according to one embodiment of the present invention. [Figure 5] FIG. 5 is an exemplary diagram illustrating a signal structure for a dose-based injection sequence according to one embodiment of the present invention. [Figure 6] FIG. 6 is an exemplary diagram illustrating a signal structure for a rate-based injection sequence according to one embodiment of the present invention. [Figure 7] FIG. 7 is a table illustrating an example rate-based injection sequence according to one embodiment of the present invention. [Figure 8] FIG. 8 is an exemplary diagram showing a signal structure for the rate-based injection sequence shown in FIG. [Figure 9] FIG. 9 is an exemplary diagram showing a signal structure in which an infusion sequence for a prandial infusion mode is applied to the rate-based infusion sequence for a basal infusion mode shown in FIG. [Figure 10] FIG. 10 is a block diagram showing a schematic configuration of the electroosmotic pump shown in FIG. [Figure 11] FIG. 11 is a conceptual diagram that schematically shows the configuration of the drive unit shown in FIG. [Figure 12] FIG. 12 is an exemplary diagram illustrating the operation of the driving unit shown in FIG. [Figure 13] FIG. 13 is an exemplary application diagram of a drug injection device according to one embodiment of the present invention. [Figure 14] FIG. 14 is a block diagram showing the schematic configuration of the drug injection device shown in FIG. [Figure 15] FIG. 15 is a flow chart illustrating a drug injection method according to one embodiment of the present invention. DETAILED DESCRIPTION OF THE INVENTION

[0014] The present invention will now be described in detail with reference to the accompanying drawings. However, the present invention may be embodied in various different forms and is not limited to the embodiments described herein. Furthermore, the accompanying drawings are merely provided to facilitate understanding of the embodiments disclosed herein, and the technical ideas disclosed herein are not limited by the accompanying drawings. To clearly illustrate the present invention in the drawings, parts that are not relevant to the description are omitted, and the size, shape, and form of each component shown in the drawings may be modified in various ways. The same or similar reference numerals are used throughout the specification to refer to the same or similar parts.

[0015] The suffixes "module" and "section" for components used in the following description are given or used interchangeably only for the sake of ease of drafting the specification, and do not have any distinct meanings or roles. Furthermore, in describing the embodiments disclosed herein, if it is determined that a detailed description of related publicly known technology may obscure the gist of the embodiments disclosed herein, such a detailed description has been omitted.

[0016] Throughout this specification, a part being "coupled (connected, in contact, or coupled)" to another part includes not only a "directly coupled (connected, in contact, or coupled)" part, but also an "indirectly coupled (connected, in contact, or coupled)" part with another member interposed therebetween. Furthermore, when a part "includes (comprises or comprises)" a certain component, it does not exclude other components, but means that it may further "include (comprises or comprises)" the other components, unless otherwise specified.

[0017] As used herein, ordinal terms such as "first," "second," etc. are used only to distinguish one component from another, and do not limit the order or relationship of the components. For example, a first component of the present invention may be designated as a second component, and similarly, the second component may be designated as a first component.

[0018] FIG. 1 is a block diagram showing the configuration of a drug injection device according to one embodiment of the present invention, and FIG. 2 is a block diagram showing the configuration of the drug injector shown in FIG.

[0019] Referring to FIGS. 1 and 2, a drug injection device (10) according to one embodiment of the present invention will be described. The drug injection device (10) includes a drug injector (100) and a control unit (200).

[0020] The drug injector (100) electrochemically drives the electroosmotic pump (110) to draw in a drug from a drug reservoir and then discharge the drawn-in drug into the subject.

[0021] The control unit 200 sets a control signal corresponding to an injection sequence determined according to the injection mode, and outputs the set control signal to the drug injector 100. The control unit 200 outputs a control signal corresponding to a volume-based injection sequence for the meal-prompt injection mode, or a rate-based injection sequence for the meal-extended injection mode.

[0022] Specifically, if an event for executing the meal injection mode occurs while the drug injector (100) is operating in a first rate-based injection sequence for the basal injection mode, the control unit (200) sets one or more of a volume-based injection sequence and a second rate-based injection sequence for the meal injection mode in response to the occurrence of the set event, temporarily suspends the output of a control signal corresponding to the first rate-based injection sequence for the currently executing basal injection mode, and then outputs a control signal corresponding to one or more of a volume-based injection sequence and a second rate-based injection sequence for the meal injection mode.

[0023] Here, the basal infusion mode is a drug infusion mode in which drugs are continuously injected into the user for a certain period of time to maintain the user's blood glucose level at a constant level, and the meal infusion mode is a drug infusion mode in which a predetermined amount of drugs is injected into the user when the user is eating in order to maintain the blood glucose level within the normal range depending on the amount and type of food eaten.

[0024] Meanwhile, the meal infusion mode can include an immediate meal infusion mode in which a drug is infused immediately according to the amount and type of food eaten, and an extended meal infusion mode in which a drug is infused continuously for a certain period of time. The immediate meal infusion mode can be applied when a user ingests food that immediately affects blood glucose levels, and operates according to an amount-based infusion sequence.

[0025] In the meal-instant infusion mode, the user can set the drug infusion amount based on their own meal information, and a volume-based infusion sequence corresponding to the drug infusion amount can be set. Also, when the user's meal information is entered into the bolus calculator, the drug infusion amount is calculated based on the type and composition of the meal, and a rate-based infusion sequence corresponding to the drug infusion amount can be set.

[0026] The extended meal infusion mode can also be applied when the user continues to eat food for a certain period of time, such as at a buffet or a course meal, or when the user eats food containing ingredients that cause gradual changes in blood glucose levels, and is set to operate according to a rate-based infusion sequence.

[0027] In the extended meal infusion mode, when the user sets an extended infusion period indicating the duration of the extended meal infusion mode and an extended infusion amount indicating the amount of medication to be infused during the extended infusion period based on their own meal information, a rate-based infusion sequence corresponding to the extended period and the extended infusion amount can be set. Furthermore, when the user's meal information is entered into the bolus calculator, the extended infusion period and the extended infusion amount are calculated according to the type and composition of the meal, and a rate-based infusion sequence corresponding to the extended infusion period and the extended infusion amount is set. For example, if the bolus calculator determines based on the meal information that the meal is centered on fat and protein rather than carbohydrates, it can recommend extended infusion based on this and calculate the extended infusion period and the extended infusion amount.

[0028] Once the extended infusion period and the extended infusion volume are determined in this manner, the rate-based infusion sequence for the prandial extended infusion mode is set in the same manner as the rate-based infusion sequence for the basal infusion mode: that is, the drug infusion rate is set so that the drug equivalent to the extended infusion volume is infused during the extended infusion period, and the rate-based infusion sequence is set.

[0029] The meal infusion mode is executed by default as the immediate meal infusion mode, and may be configured as a combination of one or more of the immediate meal infusion mode and the extended meal infusion mode depending on the selection. The detailed configurations of the immediate meal infusion mode and the extended meal infusion mode will be described later.

[0030] The control unit 200 may refer to a data processing device built into hardware having a circuit physically structured to perform a function expressed by a code or command contained in a program. Examples of such a data processing device built into hardware include a microprocessor, a central processing unit (CPU), a processor core, a multiprocessor, an application-specific integrated circuit (ASIC), a field programmable gate array (FPGA), a microcontroller unit (MCU), an embedded processor, etc., but the scope of the present invention is not limited thereto.

[0031] Meanwhile, the control unit (200) may be implemented not only as a separate unit built into the drug injection device (10), but also as a unit connected to the user terminal (40) described below via a communication module, whereby the user terminal (40) and the control unit (200) are integrated to control the food injection mode of the drug injection device (10).

[0032] Next, the structure of volume-based and rate-based injection sequences will be described.

[0033] First, the structure of the amount-based injection sequence will be described. Figure 3 is a diagram illustrating the concept of the amount-based injection sequence for the meal prompt injection mode according to an embodiment of the present invention, so the amount-based injection sequence will be described in detail with reference to Figure 3.

[0034] A volume-based infusion sequence is an arrangement of multiple pulse blocks (20) that satisfy a drug infusion amount according to meal infusion conditions or meal information. For example, when meal information is entered into a bolus calculator, the bolus calculator calculates the drug infusion amount based on the meal information, and a volume-based infusion sequence can be determined based on the drug infusion amount. In this case, the volume-based infusion sequence is configured in such a manner that multiple pulse blocks (20) that satisfy the drug infusion amount are arranged consecutively without any gaps. An infusion mode that operates with a volume-based infusion sequence is sometimes defined as a bolus infusion in a conventional insulin infusion device.

[0035] A volume-based infusion sequence consists of multiple pulse blocks (20) arranged consecutively with no breaks between each other, each defining a voltage or current pulse applied to the electroosmotic pump (110) and varying in duration to infuse different amounts of drug.

[0036] FIG. 4 is a table illustrating an example of multiple pulse blocks according to one embodiment of the present invention, and FIG. 5 is an example diagram illustrating a signal structure for a dose-based injection sequence according to one embodiment of the present invention.

[0037] 4 and 5, the structure of the amount-based injection sequence will be described by way of example. The amount-based injection sequence is set as follows to satisfy drug injection conditions including the drug injection amount: The amount-based injection sequence has a structure in which M (M is a natural number equal to or smaller than N) pulse blocks (20) selected according to the drug injection amount are arranged consecutively from N (N is a natural number) pulse blocks (20) that supply different amounts of drugs shown in FIG.

[0038] Here, the minimum number of pulse blocks (20) constituting the volume-based injection sequence that can satisfy the drug injection volume may be used, and among the pulse blocks (20) that can satisfy the drug injection volume, the pulse block (20) that supplies the largest amount of drug is placed preferentially. For example, if the drug injection volume is 5 μL, the volume-based injection sequence is composed of a fourth pulse block that supplies 3 μL and a third pulse block that supplies 2 μL, with the fourth pulse block placed first, followed by the third pulse block. Then, once the fourth pulse block and the third pulse block are completed without a gap, the third pulse block is immediately executed.

[0039] 5, each pulse block 20 includes information about a pair of pulse signals including a forward pulse and a reverse pulse, and information about the amplitude and duration of each pulse. The pair of pulse signals including a forward pulse and a reverse pulse are applied to the electroosmotic pump 110 to generate alternating negative and positive pressures, thereby generating alternating negative and positive pressures for each pulse block 20, thereby inhaling and exhaling the drug.

[0040] The pair of pulse signals (21, 22) included in the pulse block (20) may be voltage pulse signals or current pulse signals. The pair of voltage pulse signals may be composed of a forward voltage pulse and a reverse voltage pulse, and the pair of current pulse signals may be composed of a forward current pulse and a reverse current pulse. Here, the pair of voltage pulse signals may include information regarding the magnitude and duration of each voltage pulse, and the pair of current pulse signals may include information regarding the magnitude and duration of each current pulse. For example, in the dose-based injection sequence shown in FIG. 4b, the pulse signal magnitude may be 2 V and the duration may be 10 s.

[0041] Each pulse block 20 included in a dose-based injection sequence can include voltage pulses having different voltage magnitudes or current pulses having different current magnitudes, or each pulse block 20 can include pulses having the same voltage magnitude or current magnitude, but with different durations.

[0042] The forward pulse (21) and the reverse pulse (22) included in the pulse block (20) are set to have the same magnitude and duration, so that the amount of drug inhaled and expelled by the electroosmotic pump (110) can be maintained the same.

[0043] Furthermore, the pair of pulse signals (21, 22) included in the pulse block (20) may be provided at a constant voltage or a constant current, and the amount of drug inhaled and exhaled by each pulse block can be adjusted by adjusting the duration of the pulse signal provided by the constant voltage or constant current. For example, the pulse block (20) in FIG. 5 is provided by a constant voltage of 2 V.

[0044] Additionally, the pair of pulse signals (21, 22) may be adjusted in both magnitude and duration, but may be adjusted to ensure that the amounts of inhaled and exhaled drug are equal. For example, the forward voltage pulse may have a magnitude of 2 V and a duration of 10 s, followed by a reverse voltage pulse having a magnitude of 1 V and a duration of 20 s, with the areas of the forward pulse and the reverse pulse set to be the same, thereby maintaining the amounts of inhaled and exhaled drug equal.

[0045] Each pulse block 20 may further include a stabilization pulse 23, which maintains a 0 V voltage for a predetermined time after the application of the forward voltage pulse 21 and the reverse voltage pulse 22. The stabilization pulse 23 may stabilize the operation of the electroosmotic pump 110. Here, if the pulse block 20 of the volume-based injection sequence is composed of a pair of current pulses, the pulse block 20 may further include a stabilization pulse 23 which maintains a 0 A current for a predetermined time after the application of the forward current pulse and the reverse current pulse.

[0046] When a control signal corresponding to such a volume-based injection sequence is applied to the electroosmotic pump 110, the electroosmotic pump 110 generates alternating negative and positive pressures for each pulse block, thereby drawing in and expelling the drug. Here, the control signal may be a signal consisting of a voltage pulse pair including a forward voltage pulse and a reverse voltage pulse or a current pulse pair including a forward current pulse and a reverse current pulse for each pulse block 20.

[0047] Next, the structure of a rate-based infusion sequence will be described. Figure 6 is an exemplary diagram showing the signal structure of a rate-based infusion sequence for a basal infusion mode according to one embodiment of the present invention. The rate-based infusion sequence is configured by arranging multiple pulse blocks that satisfy a drug infusion period and a drug infusion rate, and by arranging multiple pulse blocks that satisfy a drug infusion rate in a unit time (e.g., 1 hour or 30 minutes), and repeating this during the drug infusion period.

[0048] Referring to FIG. 6, a rate-based injection sequence includes at least one pulse block (20) that defines a voltage or current pulse to be applied to the electroosmotic pump (110) and at least one rest block (30) that maintains a 0 V voltage or 0 A current for a predetermined period of time after the application of the pulse block.

[0049] The basal infusion mode is a mode in which multiple rate-based infusion sequences are arranged consecutively during a set drug infusion period. In the basal infusion mode, the drug infusion period can be divided into multiple segments by user configuration. Here, each segment includes information on the duration and the drug infusion rate during the duration, and each segment is configured by repeatedly arranging rate-based infusion sequences set per unit time to satisfy the drug infusion rate during the duration. The duration and drug infusion rate of each segment can be configured by the user.

[0050] Meanwhile, a rate-based infusion sequence that satisfies the drug infusion period and drug infusion rate is set as follows. First, to satisfy the drug infusion rate, pulse blocks must be placed to satisfy the drug infusion amount per unit time. In the present invention, various pulse blocks can be set through the electroosmotic pump (110). However, during the drug infusion period, if possible, multiple or a predetermined number of pulse blocks are placed, and the pause periods of the pause blocks placed after each pulse block are kept as short as possible to prevent the drug from drying out or clogging. To satisfy these conditions, the rate-based infusion sequence can be set as follows.

[0051] A rate-based infusion sequence includes M pulse blocks (20) (M is a natural number equal to or less than N) selected from N pulse blocks (20) (N is a natural number equal to or greater than N) that supply different amounts of drug, and the M pulse blocks (20) are selected based on the drug infusion rate per unit time. The multiple pulse blocks (20) and pause blocks (30) that make up the rate-based infusion sequence are configured in a combination that satisfies the drug infusion rate while the duration of each pause block (30) is less than the recommended pause period. Here, the number of pulse blocks (20) that make up the rate-based infusion sequence may be a preset number based on the unit time, or the maximum number that can indicate the drug infusion rate.

[0052] The total duration of the multiple pulse blocks (20) included in the rate-based infusion sequence and the multiple pause blocks (30) placed after the pulse blocks (20) is set to correspond to a unit time, and the pulse blocks (20) are placed so that the pulse block (20) that supplies the largest amount of drug among the pulse blocks (20) is output first, but the placement of subsequent pulse blocks (20) may vary depending on the selection.

[0053] In addition, the M pulse blocks (20) that make up the rate-based infusion sequence may be set so that the total number of uses for each selected pulse block (20) is a preset number or a maximum number while satisfying the drug infusion rate of the drug infusion conditions, and so that the duration of the pause block (30) placed after each pulse block (20) is less than the recommended pause period.

[0054] Furthermore, since the meal-extended infusion mode is also a mode in which a fixed amount of drug is continuously infused for a fixed period of time, a rate-based infusion sequence is set as the infusion sequence for the meal-extended infusion mode.

[0055] Next, an example of the operation of the basal infusion mode when the meal infusion mode is executed will be described.

[0056] FIG. 7 is a table illustrating an example of a rate-based injection sequence for a basal injection mode according to one embodiment of the present invention, and FIG. 8 is an example diagram illustrating a signal structure for the rate-based injection sequence shown in FIG. 7.

[0057] 7 and 8, the basal infusion mode is described by way of example. In the rate-based infusion sequence for the basal infusion mode shown in Fig. 7, 24 hours are divided into multiple segments, each segment having a set duration and drug infusion rate. The drug injector 100 performs the basal infusion mode by progressing through each segment in the order shown in Fig. 8.

[0058] Figure 9 is an exemplary diagram showing a signal structure in which an infusion sequence for a meal infusion mode is applied to the rate-based infusion sequence shown in Figure 8. With reference to Figure 9, the operation of executing the meal infusion mode while the drug injector 100 is operating in a rate-based infusion sequence for a basal infusion mode will be described.

[0059] First, the operation of the medication injector 100 will be described in which the meal prompt infusion mode is implemented while the medication injector 100 is operating in the basal infusion mode.

[0060] As shown in FIG. 9, when the meal-instant infusion mode is executed at time t1 while the drug injector (100) is performing a rate-based infusion sequence for the basal infusion mode, the control unit (200) places a volume-based infusion sequence for the meal-instant infusion mode starting from time t1, interrupts the rate-based infusion sequence for the basal infusion mode, and then generates a control signal consisting of a voltage pulse or current pulse corresponding to the volume-based infusion sequence based on the information of the pulse block (20) included in the volume-based infusion sequence and applies it to the drug injector (100).

[0061] Upon receiving the control signal, the medication injector 100 immediately performs the meal instant infusion mode based on the volume-based infusion sequence. Then, when the meal instant infusion mode is completed at time t2, the control unit 200 again outputs a control signal for the rate-based infusion sequence that was temporarily suspended at time t2 to the medication injector 100.

[0062] At this time, the control unit (200) can additionally perform the operations omitted from time t1 to time t2 of the rate-based injection sequence after time t2 while the volume-based injection sequence for the meal instant injection mode is being performed.

[0063] Specifically, the control unit (200) can count the omitted pulse blocks (20) between time t1 and time t2 of the rate-based injection sequence, and rearrange the omitted pulse blocks (20) into a pause block (30) positioned after time t2 and apply it to the drug injector (100).

[0064] The control unit 200 arranges the omitted pulse blocks 20 so as not to exceed the time of the pause blocks 30, and if the omitted pulse blocks 20 exceed the time of the pause blocks 30, arranges some of the pulse blocks 20 in the next pause block 30. For example, if three pulse blocks 20 are omitted between time t1 and time t2, and all three are arranged in the first pause block 30 after time t2, and the time of the pause block 30 is exceeded, the pulse blocks 20 that exceed that time are arranged in the next pause block 30.

[0065] In addition, the control unit (200) can omit the operation of the rate-based injection sequence from time t1 to time t2 while the volume-based injection sequence for the meal instant injection mode is being performed, and continue to output control signals for the rate-based injection sequence that was set at time t2 when the operation of the meal instant injection mode was completed.

[0066] The operation of the extended meal infusion mode will now be described while medication infusion device 100 is operating in the basal infusion mode.

[0067] While operating in the basal infusion mode, when the meal-extended infusion mode is executed, a portion of the drug infusion amount can be infused in a volume-based infusion sequence for the meal-prompt infusion mode and the remainder in a rate-based infusion sequence for the meal-extended infusion mode, depending on the user's settings. The meal-extended infusion mode requires the user to additionally input the extended infusion period and set the rate-based infusion sequence.

[0068] Generally, when both the meal-prompt infusion mode and the meal-extended infusion mode are implemented, the volume-based infusion sequence is performed first, and after the volume-based infusion sequence is completed, the rate-based infusion sequence is performed. Alternatively, the entire drug infusion amount can be infused in the meal-extended infusion mode.

[0069] First, referring to Figure 9, the operation of performing the entire drug infusion amount in the extended meal infusion mode will be described. If the extended meal infusion mode is set from time t1 to time t2 while the first rate-based infusion sequence for the basal infusion mode is being performed, the control unit (200) can generate a third rate-based infusion sequence that combines the operation of the first rate-based infusion sequence between time t1 and time t2 and the second rate-based infusion sequence for the extended meal infusion mode, and apply this to the drug injector (100). Because both the basal infusion mode and the extended meal infusion mode are set as rate-based infusion sequences, the two sequences can be combined. Therefore, a third rate-based sequence that combines the first rate-based infusion sequence and the second rate-based infusion sequence can be generated between time t1 and time t2.

[0070] 7 and 9, for example, the second and third segments are connected between time t1 and time t2 of the first rate-based injection sequence, where the second and third segments are partially arranged. The portion where the second segment is arranged operates at 0.8 U / h, and the portion where the third segment is arranged operates at 0.4 U / h. If the second rate-based injection sequence operates at 1.5 U / h, the control unit 200 can combine the first rate-based injection sequence and the second rate-based injection sequence to generate a third rate-based injection sequence in which the portion corresponding to the first segment operates at 2.3 U / h and the portion corresponding to the second segment operates at 1.9 U / h.

[0071] In addition, the control unit (200) may not combine the first rate-based injection sequence with the second rate-based injection sequence, and may perform only the second rate-based injection sequence, and then omit the operation of the first rate-based injection sequence between time t1 and time t2.

[0072] Next, a description will be given of an operation in which a meal infusion mode that performs both a meal-prompt infusion mode and a meal-extended infusion mode is executed during operation of the basal infusion mode. When a meal infusion mode consisting of the meal-prompt infusion mode and the meal-extended infusion mode is set between time t1 and time t2 of a first rate-based infusion sequence for the basal infusion mode, a volume-based infusion sequence for the meal-prompt infusion mode and a second rate-based infusion sequence for the meal-extended infusion mode are sequentially arranged starting from time t1.

[0073] Then, the first rate-based infusion sequence for the basal infusion mode is interrupted, and the volume-based infusion sequence and the second rate-based infusion sequence are performed consecutively. The operation of the first rate-based infusion sequence for the portion where the volume-based infusion sequence for the meal-prompt infusion mode is arranged may be relocated to a pause block (30) arranged after time t2 and performed additionally, and the operation of the second rate-based infusion sequence for the meal-extended infusion mode may be performed by combining the first rate-based infusion sequence and the second rate-based infusion sequence to generate a third rate-based infusion sequence.

[0074] Alternatively, after the volume-based injection sequence and the second rate-based injection sequence are performed in sequence, the operation of the first rate-based injection sequence between time t1 and time t2 may be omitted.

[0075] Generally, the meal infusion mode defaults to the immediate meal infusion mode, and the extended meal infusion mode can be selected by the user, allowing for a mixture of the immediate meal infusion mode and the extended meal infusion mode to be performed.

[0076] FIG. 10 is a block diagram showing a schematic configuration of the electroosmotic pump shown in FIG.

[0077] 10, the electroosmotic pump 110 includes a driving unit 111 and a chamber 112. The driving unit 111 is electrochemically driven by a control signal to generate positive and negative pressures and discharge a drug in response to the positive and negative pressures, while the chamber 112 draws in the drug from the drug reservoir 120 in response to the pressure of the driving unit 111 and then discharges the drug into the insertion unit 130. Here, the drug is a drug to be injected into a specific patient, such as insulin injected into a diabetic patient.

[0078] FIG. 11 is a block diagram schematically showing the configuration of the driving unit shown in FIG. 10, and FIG. 12 is an exemplary diagram schematically showing the configuration of the driving unit shown in FIG.

[0079] 11 and 12, the driving unit (111) is a pump that utilizes the electroosmotic phenomenon that occurs when a voltage or current is applied to both ends of a porous membrane (membrane 111a) using electrodes, causing fluid to move. The driving unit (111) includes a power source (111d) that applies a voltage or current to the membrane (111a) and first and second electrodes (111b and 111c) disposed on both sides of the membrane (111a), and a flow path for the fluid to move.

[0080] The actuator 111 may include a first diaphragm 111e disposed adjacent to the first electrode 111b and a second diaphragm 111f disposed adjacent to the second electrode 111c. Each diaphragm 111e, 111f is provided on one side and the other side of the membrane 111a, and changes shape as the pumping solution moves due to the alternating generation of positive and negative pressures. For example, the first diaphragm 111e and the second diaphragm 111f transmit the negative and positive pressures generated by the actuation of the membrane 111a to the fluid to be pumped. More specifically, when negative pressure is generated, at least a portion of the first diaphragm (111e) and the second diaphragm (111f) moves backward (when moving in direction 1), and the fluid to be transferred is sucked into the chamber (112), and conversely, when positive pressure is generated, at least a portion of the first diaphragm (111e) and the second diaphragm (111f) moves forward (when moving in direction 2), and the fluid to be transferred is discharged from the chamber (112).

[0081] The porous membrane (111a) is generally made of silica or glass, which becomes negatively charged on its surface when immersed in an aqueous solution. The porous membrane (111a) has numerous fluid-passing channels. A close-up of one of these channels reveals that the surface of the negatively charged fluid channel can be balanced by mobile positively charged cations. Applying a positive voltage to the first electrode (111b) and a negative voltage to the second electrode (111c) generates negative pressure, which moves the fluid inside the actuator (111) in the direction indicated by arrow 1. The drug is then drawn into the inlet channel (141) and flows into the chamber (112) through the inlet valve (140). The outlet valve (150) is closed, preventing negative pressure from being transmitted to the outlet channel (151). Conversely, when a negative voltage is applied to the first electrode (111b) and a positive voltage is applied to the second electrode (111c), a reversible electrochemical reaction generates a positive pressure in the opposite direction. This positive pressure causes the fluid inside the actuator (111) to move in the direction of 2. At this time, the drug stored in the chamber (112) is injected into the subject through the discharge valve (150) and the discharge path (151). At this time, the intake valve (140) is closed, preventing positive pressure from being transmitted to the intake path (141).

[0082] This phenomenon is called electroosmosis, and a pump that utilizes this principle is the electroosmotic pump (110).

[0083] The electrodes used in the driving unit (111) may be provided in the form of porous electrodes such as platinum mesh, porous carbon paper or fiber, or various electrode materials coated on a porous structure to facilitate fluid movement.

[0084] In addition, the electrodes used in the actuator 111 may be applied to a non-transparent substrate and may be coated with various immobilizable materials by drop coating, spin coating, etc. In this case, the non-transparent substrate may be a plate-shaped substrate including at least one of a conductive material, a semiconductor material, and a non-conductive material, and the electrode material coated thereon may be a metal, a metal oxide, a conducting polymer, a metal hexacyanoferrate, a carbon nanostructure, or a composite thereof.

[0085] The driving unit (111) alternately supplies voltage or current polarity to the first electrode (111b) and the second electrode (111c), respectively, causing reversible forward and reverse electrochemical reactions. The repeated forward and reverse electrochemical reactions cause the fluid inside the electroosmotic pump to repeatedly reciprocate. The repeated reversible forward and reverse electrochemical reactions also cause the electrode material at the first electrode (111b) and the second electrode (111c) to be repeatedly consumed and regenerated. When the suction valve (140) and the discharge valve (150) are respectively connected to the chamber (112) of the electroosmotic pump (110), during the suction operation, the drug in the drug reservoir (120) is drawn in through the suction passage (141) and stored in the chamber (112) via the suction valve (140). During the discharging operation, the medicine stored in the chamber (112) is discharged through the discharge valve (150) and the discharge passage (151) into the insertion part (130).

[0086] Therefore, the pressure generated by the electroosmotic pump (110) and the volume of the drug discharged can be controlled by controlling the magnitude and duration of the voltage or current applied to the first and second electrodes (111b, 111c).

[0087] Figure 13 is an exemplary application diagram of a drug injection device according to one embodiment of the present invention, and Figure 14 is a block diagram showing the schematic configuration of the drug injection device shown in Figure 13. The operation of the drug injection device 10 will be described in detail with reference to Figures 13 and 14.

[0088] The medication injection device 10 receives predetermined information input from a user or receives predetermined information from an external device, and based on the information, sets one or more of a volume-based injection sequence for the meal-prompt injection mode and a rate-based injection sequence for the meal-extended injection mode. The process of setting one or more of a volume-based injection sequence for the meal-prompt injection mode and a rate-based injection sequence for the meal-extended injection mode will now be described.

[0089] The medication injection device 10 detects an event requesting activation of the meal injection mode and sets one or more of a volume-based injection sequence and a rate-based injection sequence. The medication injection device 10 may further include a communications module 300 and a user input / output interface 400 for detecting an event requesting activation of the meal injection mode.

[0090] When an event requesting activation of a meal injection mode is detected through a user terminal (40) communicatively connected to the communication module (300) or a user input / output interface (400) executed by the control unit (200), the control unit (200) inputs a meal injection amount or meal information as a meal injection condition through the user terminal (40) or the user input / output interface (400), determines a medication injection amount based on the user's meal information through a bolus calculator, and sets one or more of a volume-based injection sequence and a rate-based injection sequence. Here, the meal information may include information such as the type and amount of food the user will ingest.

[0091] The control unit 200 receives a selection of at least one of a meal-instant infusion mode and a meal-extended infusion mode through the user input / output interface 400, and sets at least one of a volume-based infusion sequence and a rate-based infusion sequence according to the selection. When only the meal-instant infusion mode is selected through the user interface 400, the control unit 200 sets a volume-based infusion sequence corresponding to the amount of drug infusion.

[0092] Furthermore, when the meal-extended infusion mode is selected through the user interface 400, the control unit 200 can set a portion of the drug infusion amount to a volume-based infusion sequence for the meal-prompt infusion mode and the remaining amount to a rate-based infusion sequence for the meal-extended infusion mode, depending on the user's settings. Here, the control unit 200 can set the rate-based infusion sequence by additionally inputting an extended infusion period through the user interface 400. Generally, when both the meal-prompt infusion mode and the meal-extended infusion mode are executed, the volume-based infusion sequence is performed first, and after the volume-based infusion sequence is completed, the rate-based infusion sequence is performed.

[0093] Additionally, the meal infusion mode will only be performed in the meal immediate infusion mode unless the meal extended infusion mode is selected, as the meal immediate infusion mode is performed by default.

[0094] In addition, one or more of the volume-based infusion sequence and the rate-based infusion sequence may be selected directly by the user through the user terminal (40) based on the user's past drug infusion device usage history, or may be calculated and received through an external computing device, without being set using meal infusion conditions or meal information.

[0095] The user terminal 40 connected to the drug injection device 10 may be embodied as a computer or a mobile terminal that can connect to the drug injection device 10 via wireless communication. Here, the computer may include, for example, a notebook computer, desktop computer, or laptop computer equipped with a web browser, and the mobile terminal may include, for example, any type of handheld-based wireless communication device that ensures portability and mobility, such as various smartphones, tablet PCs, and smart watches. Such a user terminal 40 is managed by the wearer of the drug injection device 10 or a medical professional, and drug infusion conditions or dietary information can be set through an application running on the user terminal 40.

[0096] The input / output interface module 400 may include physical input / output buttons coupled to an external housing including the drug injection device 10, and a signal processing circuit for transmitting signals generated in response to the operation of the physical input / output buttons to the control unit 200. Alternatively, the user input / output interface module 400 may output a setting UI through a touch screen display to guide the user to input information regarding meal injection conditions or meal information.

[0097] Thereafter, when the operation of the meal infusion mode is completed, the control unit (200) continues to output the control signal for the rate-based infusion sequence for the suspended basal infusion mode, but omits the rate-based infusion sequence operation scheduled during the suspended period, and continues to perform the operation according to the rate-based infusion sequence of the basal infusion mode scheduled at the time the operation of the infusion sequence for the meal infusion mode is completed.

[0098] FIG. 15 is a flow chart illustrating a drug injection method according to one embodiment of the present invention.

[0099] 1, 2, and 15, a drug infusion method (S100) according to one embodiment of the present invention will be described. In the drug infusion method (S100), the control unit (200) sets a control signal corresponding to a volume-based infusion sequence for a meal-prompt infusion mode or a rate-based infusion sequence for a meal-extended infusion mode (step S110), and applies the control signal corresponding to the infusion sequence to the electroosmotic pump (110) (step S120). Thereafter, in response to the control signal, the electroosmotic pump (110) alternately generates negative and positive pressure for each pulse block, sucking and expelling the drug, and injecting the drug into the user (step S130).

[0100] Each stage will be explained in detail below.

[0101] In the process of setting the control signal (step S110), the drug injection device (10), which is operating according to a rate-based injection sequence for the basal injection mode, receives predetermined information from the user or receives predetermined information from an external device, and based on this, sets one or more of a volume-based injection sequence and a rate-based injection sequence for the meal injection mode.

[0102] Specifically, the process of setting the control signal (step S110) will be described. When the drug injection device (10) detects an event requesting activation of the meal injection mode through the user terminal (40) communicatively connected to the communication module (300) or the user input / output interface (400) executed by the control unit (200), the control unit (200) inputs the amount of drug injection or meal information as a meal injection condition through the user terminal (40) or the user input / output interface (400).

[0103] In addition, one or more of a volume-based infusion sequence for the immediate meal infusion mode and a rate-based infusion sequence for the extended meal infusion mode can be set according to the meal infusion conditions entered by the user. Alternatively, a volume-based infusion sequence can be set according to the drug infusion amount calculated by the bolus calculator based on the meal infusion conditions entered by the user, or a rate-based infusion sequence can be set according to the drug infusion duration and drug infusion amount calculated by the bolus calculator. Here, the meal information can include information such as the type and amount of food the user ingests.

[0104] Additionally, in the process of setting one or more of a volume-based injection sequence for the immediate meal injection mode and a rate-based injection sequence for the extended meal injection mode, the control unit (200) selects one or more of the immediate meal injection mode and the extended meal injection mode through the user input / output interface (400), and sets one or more of a volume-based injection sequence and a rate-based injection sequence according to the selection.

[0105] Here, the meal infusion mode is performed in the meal immediate infusion mode by default, so if the meal extended infusion mode is not selected, the control unit (200) sets a volume-based infusion sequence corresponding to the drug infusion amount and executes in the meal immediate infusion mode.

[0106] Additionally, the control unit (200) may set the volume-based injection sequence or the rate-based injection sequence by referring to a table storing multiple volume-based injection sequences or rate-based injection sequences corresponding to meal injection conditions or meal information, or the volume-based injection sequence or the rate-based injection sequence may be selected directly by the user through the user terminal (40) or calculated and received through an external computing device based on the user's past use history of the drug injection device without using the meal injection conditions or meal information.

[0107] In the process of applying a control signal to the electroosmotic pump (step S120), if the drug injector (100) is operating in a basal infusion mode with a rate-based infusion sequence, the control unit (200) temporarily suspends the output of the control signal corresponding to the rate-based infusion sequence and outputs a control signal corresponding to an infusion sequence for a meal infusion mode to the drug injector (100).

[0108] Then, in the process of injecting a drug into the user (step S130), the control signal corresponding to the dose-based injection sequence may include a voltage pulse pair including a forward voltage pulse and a reverse voltage pulse or a current pulse pair including a forward current pulse and a reverse current pulse in pulse block units. Through such control signals, the electroosmotic pump alternately generates negative and positive pressure for each pulse block, thereby performing the operation of inhaling and expelling the drug, and the drug can be injected into the user in a dietary injection mode.

[0109] Thereafter, when the meal infusion mode ends, the control unit (200) continues to output control signals for the rate-based infusion sequence for the suspended basal infusion mode, but may additionally perform or omit operations of the rate-based infusion sequence for the basal infusion mode that were scheduled during the suspended period.

[0110] The operation of additionally performing the rate-based infusion sequence operation for the basal infusion mode that was scheduled during the suspended period of the meal infusion mode may vary depending on the operation that configures the meal infusion mode.

[0111] First, a case where the meal-prompt infusion mode is executed during operation of the basal infusion mode will be described with reference to Figure 9. If a volume-based infusion sequence for the meal-prompt infusion mode is set between time t1 and time t2 of the rate-based infusion sequence for the basal infusion mode, the operation of the rate-based infusion sequence set between time t1 and time t2 can be repositioned and executed after time t2.

[0112] Next, a case where the extended meal infusion mode is executed during operation of the basal infusion mode will be described. If a second rate-based infusion sequence for the extended meal infusion mode is set between time t1 and time t2 of the first rate-based infusion sequence for the basal infusion mode, a third rate-based infusion sequence that combines the first rate-based infusion sequence for the basal infusion mode and the second rate-based infusion sequence for the extended meal infusion mode can be generated and executed.

[0113] Next, a case will be described in which both the meal-prompt infusion mode and the meal-extended infusion mode are executed during operation of the basal infusion mode. If both a volume-based infusion sequence for the meal-prompt infusion mode and a second rate-based infusion sequence for the meal-extended infusion mode are set between time t1 and time t2 of the first rate-based infusion sequence for the basal infusion mode, the operation of the first rate-based infusion sequence in the portion where the volume-based infusion sequence is set can be rearranged and executed after time t2, and the operation of the first rate-based infusion sequence in the portion where the second rate-based infusion sequence is set can be executed by generating a third rate-based infusion sequence that combines the second rate-based infusion sequence.

[0114] Additionally, when the meal infusion mode is set, the operation from time t1 to time t2 in the basal infusion mode can be omitted, and the set operation can be performed from time t2.

[0115] A method according to an embodiment of the present invention may also be embodied in the form of a recording medium containing computer-executable commands, such as a program module executed by a computer. A computer-readable medium may be any available medium accessible by a computer, including both volatile and nonvolatile media, removable and non-removable media. A computer-readable medium may also include computer storage media. A computer storage medium includes both volatile and nonvolatile, removable and non-removable media embodied in any method or technology for storage of information, such as computer-readable commands, data structures, program modules, or other data.

[0116] Additionally, although the methods and systems of the present invention have been described in connection with particular embodiments, some or all of their components or operations may be implemented using a computer system having a general-purpose hardware architecture.

[0117] Those skilled in the art will understand that the present invention can be easily modified into other specific forms based on the above description without changing the technical idea or essential characteristics of the present invention. Therefore, the above-described embodiments should be understood to be illustrative in all respects and not limiting. The scope of the present invention is defined by the claims set forth below, and all modifications and variations derived from the meaning and scope of the claims and their equivalents should be construed as being within the scope of the present invention.

[0118] The scope of the present application is indicated by the claims that follow rather than by the above detailed description, and all modifications and variations that fall within the meaning and scope of the claims and their equivalents should be construed as being included within the scope of the present application.

Claims

1. In a drug injection device, A drug injector that electrochemically drives an electroosmotic pump to inhale a drug from a drug reservoir and discharge the inhaled drug into an injection target; a control unit that outputs a control signal to the drug injector corresponding to an injection sequence determined according to an injection mode; the control unit outputs a control signal corresponding to a volume-based infusion sequence for a meal-prompt infusion mode or a rate-based infusion sequence for an extended meal infusion mode; The electroosmotic pump alternately generates negative and positive pressure in response to the control signal to draw in and eject the drug.

2. The control unit suspending operation according to the first rate-based infusion sequence for the basal infusion mode in response to the occurrence of the configured event; 10. The medication infusion device of claim 1, which outputs a control signal corresponding to a second rate-based infusion sequence for a meal-extended infusion mode or a volume-based infusion sequence for a meal-immediate infusion mode.

3. The control unit Upon completion of the meal instant infusion mode of operation, continue to output the control signal for the suspended first rate-based infusion sequence, but 3. The drug injection device of claim 2, wherein operations according to the first rate-based infusion sequence scheduled during the suspended period are performed after the operation of the meal instant infusion mode is completed.

4. The drug injection device of claim 2, wherein the control unit performs a third rate-based injection sequence that combines the first rate-based injection sequence and the second rate-based injection sequence during operation in the extended meal injection mode.

5. The control unit and continuing to output the control signal for the suspended first rate-based infusion sequence upon completion of operation of the extended meal infusion mode or the immediate meal infusion mode. The drug injection device of claim 2, wherein operations according to the first rate-based infusion sequence scheduled during the suspended period are omitted, and operations according to the first rate-based infusion sequence scheduled at the time operation of the extended meal infusion mode or immediate meal infusion mode is completed.

6. the rate-based injection sequence includes at least one pulse block that defines a voltage pulse or a current pulse to be applied to the electroosmotic pump, and at least one pause block that maintains a 0 V voltage or a 0 A current for a predetermined period of time after application of the pulse block; each of the pulse blocks defines a pair of pulse signals to be applied to the electroosmotic pump, the pulse signals including a forward pulse and a reverse pulse that alternately generate negative and positive pressures; 2. The drug infusion device of claim 1, wherein the electroosmotic pump alternately generates negative and positive pressure for each pulse block to draw in and eject the drug.

7. the rate-based infusion sequence is a sequence of pulse blocks arranged to satisfy a drug infusion rate according to drug infusion conditions including a drug infusion duration and a drug infusion rate; 7. The drug injection device of claim 6, wherein the sum of the durations of the plurality of pulse blocks and the durations of the plurality of pause blocks arranged after the pulse blocks is set to correspond to the drug injection period.

8. the rate-based injection sequence is an arrangement of the plurality of pulse blocks and pause blocks in a unit time; 7. The drug infusion device of claim 6, wherein the control unit provides the rate-based infusion sequence repeatedly during the drug infusion period.

9. 8. The medication infusion device of claim 7, wherein the rate-based infusion sequence is configured such that the duration of each pause block is less than a recommended pause period.

10. 8. The drug injection device of claim 7, wherein the rate-based injection sequence is arranged such that the pulse block that supplies the greatest amount of drug is output first among the plurality of pulse blocks.

11. The rate-based infusion sequence is an arrangement of M pulse blocks (M is a natural number equal to or smaller than N) selected from N pulse blocks (N is a natural number) that supply different amounts of drug from each other according to drug infusion conditions; The drug infusion conditions include a drug infusion period and a drug infusion rate; 7. The drug injection device of claim 6, wherein the sum of the durations of the selected M pulse blocks and the durations of the plurality of pause blocks placed after each pulse block is set to correspond to the drug injection period.

12. The drug injection device of claim 6, wherein the rate-based injection sequence is set so that the M pulse blocks satisfy the drug injection rate of the drug injection condition, the total number of times each selected pulse block is used is a preset number or a maximum number, and the duration of the pause block placed after each pulse block is less than the recommended pause period.

13. The drug injection device of claim 7, wherein the rate-based injection sequence is set so that the drug injection rate is the same for some segments and different for other segments according to the segments obtained by dividing the drug injection period into predetermined time units, and the arrangement of pulse blocks and pause blocks assigned to each segment is set.

14. The pulse block and the pause block are formed into a group, and a duration of the group is set as a first time; 7. The drug infusion device of claim 6, wherein the duration of the pause block is set as a second time obtained by subtracting the duration of the pulse block from the first time.

15. the volume-based injection sequence includes at least one or more pulse blocks that define voltage or current pulses applied to the electroosmotic pump; each of the pulse blocks defines a pair of pulse signals to be applied to the electroosmotic pump, the pulse signals including a forward pulse and a reverse pulse that alternately generate negative and positive pressures; 2. The drug infusion device of claim 1, wherein the electroosmotic pump alternately generates negative and positive pressure for each pulse block to draw in and eject the drug.

16. The drug injection device of claim 15, wherein the volume-based injection sequence is an arrangement of M pulse blocks (M is a natural number less than or equal to N) selected from N pulse blocks (N is a natural number) that supply different amounts of drug, with the largest pulse block that satisfies the target drug injection amount being preferentially arranged.

17. The drug injection device of claim 15, wherein the volume-based injection sequence prioritizes the placement of the largest pulse block that satisfies the target drug injection volume, but if the sequence includes multiple pulse blocks, each pulse block is placed consecutively.

18. The pair of pulse signals The voltage pulse pair includes a forward voltage pulse and a reverse voltage pulse, and includes a stabilization pulse that maintains a 0V voltage for a predetermined time after the application of the forward voltage pulse and the reverse voltage pulse.

16. The drug injection device of claim 15, comprising a current pulse pair including a forward current pulse and a reverse current pulse, and including a stabilization pulse that maintains a current of 0 A for a predetermined period of time after the application of the forward current pulse and the reverse current pulse.

19. The control unit When an event requesting activation of a meal injection mode is detected through a user interface executed by the control unit, The user may input a drug infusion amount as a meal infusion condition through the user interface, or may determine a drug infusion amount based on the user's meal information through a bolus calculator; 10. The drug infusion device of claim 1, wherein the volume-based infusion sequence or the rate-based infusion sequence is configured to satisfy the drug infusion amount.

20. The control unit One or more of an immediate infusion amount and an extended infusion period is input through the user interface; The drug injection device of claim 19 generates one or more of a volume-based injection sequence based on the instantaneous injection amount and a rate-based injection sequence according to a drug injection rate based on the remaining injection amount excluding the instantaneous injection amount from the drug injection amount and the extended injection period, and outputs the generated sequence as the control signal.

21. The electroosmotic pump comprises: a driving unit that is electrochemically driven by the control signal and alternately generates positive and negative pressures; 2. The drug injection device according to claim 1, further comprising a chamber that draws in the drug from the drug reservoir in response to the pressure of the drive unit and then discharges the drug into the insertion unit.

22. The drug injection device of claim 1, wherein the control unit sets the volume-based injection sequence or the rate-based injection sequence by referring to one or more of a table storing multiple volume-based injection sequences for different drug injection amounts and a table storing multiple rate-based injection sequences for different drug injection rates.

23. 1. A method for injecting a drug using a drug infusion device including an electroosmotic pump, comprising: setting the control signal corresponding to a volume-based infusion sequence for a meal-immediate infusion mode or setting the control signal corresponding to a rate-based infusion sequence for a meal-extended infusion mode; applying the control signal to the electroosmotic pump; and In response to the control signal, the electroosmotic pump alternately generates negative and positive pressures for each pulse block to inhale and expel a drug; The drug injection method for a drug injection device, wherein the electroosmotic pump alternately generates negative pressure and positive pressure in response to the control signal to suck in and eject the drug.

24. applying the control signal to the electroosmotic pump suspending operation according to the first rate-based infusion sequence for the basal infusion mode in response to the occurrence of a configured event; 24. The method of claim 23, wherein the drug infusion device outputs a control signal corresponding to a second rate-based infusion sequence for an extended meal infusion mode or a volume-based infusion sequence for an immediate meal infusion mode.

25. applying the control signal to the electroosmotic pump When the meal instant infusion mode of operation is completed, continue to output the control signal for the suspended first rate-based infusion sequence, but 25. A drug infusion method for a drug infusion device as described in claim 24, wherein operations according to the first rate-based infusion sequence scheduled during the suspended period are performed after the operation of the meal instant infusion mode is completed.

26. The drug infusion method of claim 24, wherein the step of applying the control signal to the electroosmotic pump performs a third rate-based infusion sequence that combines the first rate-based infusion sequence and the second rate-based infusion sequence during operation in the extended meal infusion mode.

27. applying the control signal to the electroosmotic pump and continuing to output the control signal for the suspended first rate-based infusion sequence upon completion of operation of the extended meal infusion mode or the immediate meal infusion mode. A drug injection method for a drug injection device as described in claim 24, which omits operations according to the first rate-based injection sequence scheduled during the suspended period and performs operations according to the first rate-based injection sequence scheduled at the time operation of the extended meal injection mode or immediate meal injection mode is completed.

28. The step of setting the control signal comprises: When an event is detected requesting activation of the meal infusion mode through the user interface, The user inputs the amount of drug infusion as a meal infusion condition through the user interface, or determines the amount of drug infusion based on the user's meal information through a bolus calculator; 24. The method of claim 23, further comprising setting the control signal to correspond to the volume-based infusion sequence or the rate-based infusion sequence that satisfies the drug infusion amount.

29. The step of setting the control signal comprises: One or more of an immediate infusion amount and an extended infusion period is input through the user interface; A drug injection method for a drug injection device as described in claim 27, wherein one or more of a volume-based injection sequence based on the instantaneous injection amount and a rate-based injection sequence according to a drug injection rate based on the remaining injection amount excluding the instantaneous injection amount from the drug injection amount and the extended injection period are generated and set as the control signal.

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