Apparatus and methods for determining and / or treating microvascular occlusion

A catheter system with controlled coronary fluid infusion allows for real-time diagnosis and treatment of microvascular occlusion, addressing the inadequacies of existing methods and improving patient outcomes in STEMI patients.

JP7876535B2Active Publication Date: 2026-06-19CORFLOW THERAPEUTICS AG
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Patent Information

Application Number
JP2023541590
Authority / Receiving Office
JP · JP
Patent Type
Patents
Current Assignee / Owner
Priority Date
2021-01-11
Filing Date
2022-01-10
Publication Date
2026-06-19
Estimated Expiration
2042-01-10

AI Technical Summary

Technical Problem

Current methods are inadequate for diagnosing and treating microvascular occlusion (MVO) in patients with STEMI, which leads to severe long-term complications and poor patient outcomes, as existing techniques like cardiac MRI are time-consuming and ineffective in emergency situations, and conventional therapies are unsafe or ineffective.

Method used

A specialized infusion and sensing catheter system with a control console and algorithm for real-time diagnosis and treatment of microvascular dysfunction, using controlled coronary fluid infusion (CoFI) to measure vascular parameters and deliver therapeutic agents.

Benefits of technology

Enables real-time assessment and treatment of microvascular occlusion, reducing long-term complications by providing accurate and immediate interventions, improving patient outcomes.

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Abstract

Methods and systems are provided for the diagnosis and / or treatment of microvascular dysfunction, such as microvascular occlusion (MVO), by injecting volumetric flow into a blood vessel using an injection system to block or reverse intrinsic antegrade flow such that equilibrium values ​​of volumetric flow rate and corresponding pressure can be determined, which in turn allows for calculation of MVO, absolute hydrodynamic resistance, fractional flow reserve, fractional coronary flow reserve, and other physiological parameters in real time or near real time.
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Citation Information

Patent Citations

  • Intracoronary analysis of microvascular obstruction (MVO) and myocardial infarction

    JP2020534132A

  • Systems and methods for determining fractional flow reserve without adenosine or other pharmalogical agent

    US20150133799A1