METHOD FOR TREATMENT OF ACUTE KIDNEY INJURY
MA46459AInactive Publication Date: 2019-08-14MITOBRIDGE INC
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Patent Information
- Application Number
- MA46459
- Authority / Receiving Office
- MA · MA
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2017-10-05
- Filing Date
- 2017-10-05
- Publication Date
- 2019-08-14
- Estimated Expiration
- Not applicable · inactive patent
AI Technical Summary
Technical Problem
To date, there is no specific treatment for established AKI.
Benefits of technology
[0006]It has now been found that a compound, (R)-3-methyl-6-(2-((5-methyl-2-(6-(trifluoromethyl)pyridin-3-yl)-1H-imidazol-1-yl)methyl)phenoxy)hexanoic acid, represented by the following structural formula: reduced kidney injury in a rat model of acute kidney disease (see Example 2). Specifically, Compound A significantly reduced plasma creatinine levels, improves kidney function and reduces the early kidney injury biomarker NGAL, when administerd intravenously four hours after ischemic reperfusion injury was induced to the kidneys of laboratory rats.
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Abstract
The present invention relates to methods for treating a human patient suffering from acute kidney injury.
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