Improved nogo-a binding molecule

Abstract

The present invention provides a binding molecule which is capable of funding to the human NogoApolypeptide or human NiG with a dissociation constant < 1000nM, a polynucleotide encoding such binding molecule; an expression vector comprising said polynucleotide; an expression system comprising a polynucleotide capable of producing a binding molecule, an isolated host cell which comprises an expression system as defined above; the use of such binding molecule as a pharmaceutical, especially in the treatment of a disease of the peripheral (PNS) and / or central (CNS) nervous system; a pharmaceutical composition comprising said binding molecule; and a method of treatment of a disease of the pefipheral (PNS) and / or centraI (CNS) nervous system.