Current applications involve novel derivatives of chlorine E6 and its pharmacologically recognized salts, as well as their preparations and uses.
Patent Information
- Application Number
- TH1901002392
- Authority / Receiving Office
- TH · TH
- Patent Type
- Patents
- Current Assignee / Owner
- Priority Date
- 2016-12-28
- Filing Date
- 2016-12-28
- Publication Date
- 2026-08-27
- Estimated Expiration
- 2036-12-27
AI Technical Summary
Existing chlorin-based photosensitizers have room for optimization in structure and activity, resulting in high toxicity or difficulty in synthesis, and limited therapeutic effects, making them unable to meet the needs of clinical applications.
By structurally modifying chlorin e6, we designed and synthesized chlorin e6 ether amino acid derivatives, including the optimized design of etherification of 3-vinyl group with alcohol and peptide formation of 15-ethyl carboxyl group with amino acids, to form a new type of chlorin e6 ether amino acid derivatives. Chlorin e6 ether amino acid derivatives improve its therapeutic effect and reduce toxicity.
A new photosensitizer with high efficiency, low toxicity and excellent photodynamic anticancer activity was obtained, which significantly improved the killing effect on human non-small cell lung cancer and mouse melanoma cells, and the dark-to-phototoxic ratio was better than the existing ones. The photosensitizer talaporfin.