Current applications involve novel derivatives of chlorine E6 and its pharmacologically recognized salts, as well as their preparations and uses.

TH124271BActive Publication Date: 2026-08-27ลิว +1
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Patent Information

Application Number
TH1901002392
Authority / Receiving Office
TH · TH
Patent Type
Patents
Current Assignee / Owner
Priority Date
2016-12-28
Filing Date
2016-12-28
Publication Date
2026-08-27
Estimated Expiration
2036-12-27

AI Technical Summary

Technical Problem

Existing chlorin-based photosensitizers have room for optimization in structure and activity, resulting in high toxicity or difficulty in synthesis, and limited therapeutic effects, making them unable to meet the needs of clinical applications.

Method used

By structurally modifying chlorin e6, we designed and synthesized chlorin e6 ether amino acid derivatives, including the optimized design of etherification of 3-vinyl group with alcohol and peptide formation of 15-ethyl carboxyl group with amino acids, to form a new type of chlorin e6 ether amino acid derivatives. Chlorin e6 ether amino acid derivatives improve its therapeutic effect and reduce toxicity.

Benefits of technology

A new photosensitizer with high efficiency, low toxicity and excellent photodynamic anticancer activity was obtained, which significantly improved the killing effect on human non-small cell lung cancer and mouse melanoma cells, and the dark-to-phototoxic ratio was better than the existing ones. The photosensitizer talaporfin.

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Abstract

DEPCT6315 / 05 / 2562 This patent application relates to novel derivatives of chlorine E6 and its salts that have been Pharmaceutical acceptance, as well as its preparation and use, are matters of medicine. The amino acid derivative chlorine E6 ether comprises the general structural formulas I and optical. Its isomer, the process for its preparation, consists of the etherification of 3-vinyl in chlorine. RinE6 ether peptides are produced from 15-carboxyl ethyl and amino acid derivatives. Chlorin-E6 ether and its salts are pharmaceutically recognized and can be used as medicine. Antitumor activity by photodynamic means compared to the photosensitizer thalaporfin used in... A similar clinical trial previously conducted on the amino acid derivative chlorine E6 ether of this patent application has... Enhanced photodynamic antitumor activity and dark toxicity ratio. -High photosensitivity, a novel photodynamic antitumor drug prepared includes: Photodynamic anticancer drugs are used to treat non-vascular tumors. Severe photodynamic diseases such as macular degeneration and subdural hemorrhages can occur. Age-related skin conditions and a photodynamic treatment for genital warts. (chemical formula) (I) ----------------------------------------------------------- DEPCT63 Current applications involve novel derivatives of chlorine E6 and its pharmaceutically recognized salts. The science, as well as its preparation and medical applications, are related to the amino acid derivative chlorine E6E. The ther consists of a general structural formula I and its optical ishomer; the preparation process involves etherification. The peptide is produced from 15-carboxyethyl and amino acid derivatives in chlorine-E6 ether. Nochlorine E6 ether and its salts are pharmacologically recognized and can be used as antitumor drugs. The photodynamic method, when compared to the photosensitizer thalaporfin previously used in treatment, utilizes amino acid derivatives. The chlorine-E6 ether currently in use exhibits better photodynamic antitumor activity and a higher toxicity ratio. Dark-induced phototoxicity; a novel photodynamic antitumor drug prepared contains photodynamic antitumor drugs. Photodynamics is a drug used to treat benign vascular tumors such as macular degeneration. It is used for age-related macular degeneration and subcutaneous capillary hypertrophy, and as a treatment for genital warts. The photodynamic method. (chemical formula) (I) -----------------------------------------------------------
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