3-hydroxypropylesters as antimicrobial agents

3-hydroxypropylesters effectively address the limitations of current antimicrobial agents by inhibiting microbial growth and sweat odor formation on human skin and in products, providing a safer, more efficient, and sustainable solution for personal care and household applications.

WO2025012263A1PCT designated stage expired Publication Date: 2025-01-16SYMRISE GMBH & CO KG
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Patent Information

Application Number
PCT/EP2024/069327
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2023-07-10
Filing Date
2024-07-09
Publication Date
2025-01-16

AI Technical Summary

Technical Problem

Current antimicrobial agents in personal care, pharmaceutical, and household products often induce undesirable side effects and fail to effectively target the diverse human skin microbiome, leading to inefficiencies in preventing microbial growth and sweat odor formation.

Method used

The use of 3-hydroxypropylesters, specifically 3-hydroxypropyldecanoate and 3-hydroxypropyldodecanoate, as antimicrobial agents that inhibit the growth of various microorganisms on human skin and in products, reducing sweat odor formation and providing synergistic antimicrobial activity when combined with other agents.

Benefits of technology

These compounds effectively reduce microbial growth and sweat odor development on human skin and in products, offering a safer and more efficient alternative with reduced side effects, while also being sustainable and cost-efficient.

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Abstract

The present invention primarily relates to use of a compound of formula (I) as defined herein as an active ingredient. Moreover, it relates to methods for inhibiting or preventing the growth of one or more microorganisms and to a method for inhibiting or reducing the conversion of sweat components to odorous compounds. It also relates to a compound of formula (I) as defined herein for use in the treatment of inflammation, post-inflammatory hyperpigmentation, atopic dermatitis, bacterial vaginosis, tinea pedis, dermatitis exfoliativa neonatorum, impetigo contagiosa, furuncles and carbuncles, folliculitis, impetigo, and / or erysipelas, and for use as an antimicrobial agent, to a mixture comprising one or both compound(s) of formula (I) as defined herein, and to a mixture comprising one or both compound(s) of formula (I) as defined herein and one or more further antimicrobial agent(s). Finally, it relates to a deodorant, rinse-off product, and leave-on product as defined herein.
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Citation Information

Patent Citations

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    US11116710B2

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    US20230149309A1

  • Antimicrobial activity of fatty acid esters and combinations thereof

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