Avian influenza nanoparticle immunogenic compositions

WO2025188781A8 Publication Date: 2025-10-02NOVAVAX INC
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Patent Information

Application Number
PCT/US2025/018378
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2024-11-13
Filing Date
2025-03-04
Publication Date
2025-10-02

AI Technical Summary

Technical Problem

There is a need for the development of safe, effective, and ideally single-dose vaccines against highly pathogenic avian influenza (HPAI) A(H5N1) viruses, which have a high fatality rate and pose a significant public health risk due to their potential for human-to-human transmissibility and pandemic potential.

Method used

The development of influenza vaccine nanoparticles composed of recombinant avian influenza hemagglutinin (HA) glycoprotein from subtype A(H5N1) combined with a Matrix-M adjuvant, forming nanoparticles through a detergent exchange process, which enhances immune response when administered intramuscularly or intranasally.

Benefits of technology

The vaccine nanoparticles induce robust innate and adaptive immune responses, including seroconverting antibodies and cell-mediated immunity, providing effective protection against A(H5N1) infections.

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Abstract

An influenza vaccine nanoparticle includes a recombinant avian influenza hemagglutinin (HA) glycoprotein, where the HA glycoprotein is derived from Type A influenza, subtype A(H5N1) and a Matrix-M adjuvant. The HA glycoprotein has a hydrophobic C-terminus associated with a component of the Matrix-M adjuvant, the component of the Matrix-M being a Matrix-A particle or a Matrix-C particle. In another embodiment, the invention is directed to a vaccine composition having a recombinant glycoprotein antigen with a C-terminus, and a Matrix-M adjuvant. The C-terminus of the glycoprotein antigen is hydrophobic and is associated with a component of the Matrix-M adjuvant.
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