A synergistic herbicidal composition

Abstract

The invention relates to a synergistic herbicidal composition for controlling undesired vegetation or weeds for longer period in plants, more particularly to a synergistic composition comprising pyroxasulfone; sulfentrazone; and at least one additional herbicide selected from clomazone, diclosulam and flumioxazin. The invention further relates to formulations and methods of controlling undesired vegetation with the composition and provides the advantages of enhanced efficacy, increased spectrum of activity, improved shelf life, improved plant vigour and yield.

Description

[0001]Title of the Invention: A SYNERGISTIC HERBICIDAL COMPOSITION FIELD OF INVENTION The present invention relates to a synergistic herbicidal composition comprising pyroxasulfone; sulfentrazone; and at least one additional herbicide selected from clomazone, diclosulam and flumioxazin. The present invention further relates to a process of preparing the said composition along with one or more inactive excipient(s) and formulation thereof. The present invention also relates to said synergistic compositions for protecting crops against weeds, undesired vegetation and grasses. BACKGROUND OF THE INVENTION In agricultural and horticultural crops, the control of undesired vegetation is extremely important in achieving high crop efficiency. Weed control or control of harmful plants at minimum dose of herbicide is preferred for ecological considerations, exposure effects of workers, and meeting out cost reduction. This can be achieved effectively by the application of herbicide mixture products. Use of pesticidal mixtures such as combination of herbicides is common to save time, labour and energy. Such mixing saves expenditure provided there are no adverse effects on the desired plants and non-target organisms. Moreover, it is widely known to combine two or more herbicides having different mechanism of action and / or a different biological target, in order to broaden the action range of the mixtures with respect to the product used individually and to prevent or delay the occurrence of resistance from the undesired vegetation. However, development of combinations or a mixture product of herbicidal active ingredients is a highly complex and challenging process. It is desirable to establish the biological compatibility of the active ingredients, avoid phyto-toxicity to the essential crop plants, ensure stability of the combination, and avoid antagonism in the herbicidal activity of the active ingredients. Pyroxasulfone is selective pre-emergence grass and broad-leaved weed herbicide. Pyroxasulfone which inhibits the biosynthesis of very long-chain fatty acids synthesis (VLCFA) is classified under group 15 (legacy group K3), of the Herbicide Resistance Action Committee (HRAC) mode of action. Pyroxasulfone is chemically known as 3-[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl) pyrazol-4- ylmethylsulfonyl]-4,5-dihydro-5,5-dimethyl-1,2-oxazole and chemical structure of Pyroxasulfone is as provided below: 1 Classification | PI External Sulfentrazone is a selective pre-emergent and post-emergent herbicide and is an effective herbicide for the control of broad-leaved weed, some grasses and sedges. It was the first herbicide of the triazolinones chemical group. Sulfentrazone which acts via the inhibition of Protoporphyrinogen Oxidase (PPO), is classified under group 14 (legacy group E), of the Herbicide Resistance Action Committee (HRAC) mode of action. Sulfentrazone is chemically known as N-[2,4-dichloro-5-[4-(difluoromethyl)-4,5-dihydro-3-methyl-5- oxo-1H-1,2,4-triazol-1-yl]phenyl]methanesulfonamide and chemical structure of sulfentrazone is as provided below: Clomazone is a selective herbicide used for the control of broad-leaved weeds and grasses in a range of crops. Clomazone which acts via the inhibition of Deoxy-D-Xyulose Phosphate Synthase (DOXPS), is classified under group 13 (legacy group F4), of the Herbicide Resistance Action Committee (HRAC) mode of action. Clomazone is chemically known as 2-((2-chlorophenyl)methyl)-4,4-dimethyl-3-isoxazolidinone and chemical structure of clomazone is as provided below: Diclosulam is a selective herbicide used to control a wide range of broadleaf weeds in agricultural crops. Diclosulam which acts via the inhibition of Acetolactate Synthase (ALS), is classified under group 2 (legacy group B), of the Herbicide Resistance Action Committee (HRAC) mode of action. Diclosulam is chemically known as N-(2,6-dichlorophenyl)-5-ethoxy-7-fluoro[1,2,4]triazolo[1,5- c]pyrimidine-2-sulfonamide and chemical structure of diclosulam is as provided below: 2 Classification | PI External Flumioxazin is a non-selective herbicide used to control a wide range of broadleaf weeds in agricultural crops. Flumioxazin which acts via the inhibition of Protoporphyrinogen Oxidase (PPO), is classified under group 14 (legacy group E), of the Herbicide Resistance Action Committee (HRAC) mode of action. Flumioxazin is chemically known as N-[7-fluoro-3, 4-dihydro-3-oxo-4-(prop-2-ynyl)-2H-1, 4- benzoxazin-6-yl] cyclohex-1-ene-1, 2-dicarboximide and chemical structure of flumioxazin is as provided below: Though there are many products of pyroxasulfone and sulfentrazone that are commercially available for controlling undesired vegetation in the desired crops, there is still a need for new mixtures and compositions that are more effective, less expensive, less toxic, have a broad spectrum, and are environmentally safe. Commelina communis, also known as the Asiatic dayflower, a problematic weed due to its rapid growth, ability to form dense colonies, and resistance to some herbicides. It can significantly reduce crop yields in fields like soybean, corn, sugarcane, wheat, bananas, and vegetables. Additionally, its ability to spread vegetatively (through stems) and via seeds makes it difficult to eradicate. Simmilarly, Impatiens balsamina (Balsam) and Euphorbia geniculata (Bracted Spurge) pose significant problems as weeds in crop fields, primarily due to competition for resources and potential allelopathic effects. They reduce crop yields, quality, and can impact the overall ecosystem. Major affected crops with these weeds are Soybeans, peanut, wheat, etc. Further, Sugar cane is important crop, Ipomoea indica, is a problematic weed in sugarcane fields, competing with the crop for resources and potentially reducing yields. Controlling this weed requires a 3 Classification | PI External multi-faceted approach, including both pre- and post-emergence herbicide applications, and potentially even manual removal in some cases. Surprisingly, the inventors of the present invention have found that, the herbicidal combination of pyroxasulfone and sulfentrazone with at least one additional herbicide selected from clomazone, diclosulam and flumioxazin; delays the generation of resistance and provides: 1. First-rate control effect (Synergistic) that cannot be expected on the basis of the activities of the herbicidal compound used alone against undesired vegetation, 2. Increased spectrum of activity, and 3. Control of undesired vegetation or harmful plants or weeds for longer period as compared to the achievable compositions disclosed in prior arts. 4. Surprisingly improved plant vigour and yield. OBJECTS OF THE INVENTION It is an object of the present invention to provide a synergistic herbicidal composition comprising: a) pyroxasulfone; b) sulfentrazone; and c) at least one additional herbicide selected from clomazone, diclosulam and flumioxazin. It is another object of the present invention to provide a synergistic herbicidal composition comprising: a) pyroxasulfone; b) sulfentrazone; c) at least one additional herbicide selected from clomazone, diclosulam and flumioxazin; and d) one or more inactive excipient(s) It is another object of the present invention to provide a method for preparing said synergistic herbicidal composition comprising: a) pyroxasulfone; b) sulfentrazone; c) at least one additional herbicide selected from clomazone, diclosulam and flumioxazin; and d) one or more inactive excipient(s) It is another object of the present invention to provide a method of selectively controlling undesirable vegetation in monocot or dicot crops selected from the group consisting of peanut, soybean and sugarcane crop comprising applying an effective amount of herbicidal composition comprising a) pyroxasulfone; 4 Classification | PI External b) sulfentrazone; c) at least one additional herbicide selected from clomazone, diclosulam and flumioxazin; and d) one or more inactive excipient(s) to the locus of such vegetation. Yet another object of the present invention is to provide a synergistic herbicidal composition comprising: a) pyroxasulfone; b) sulfentrazone; c) at least one additional herbicide selected from clomazone, diclosulam and flumioxazin; and d) one or more inactive excipient(s), wherein the said composition is in the form of wettable power (WP), water dispersible granules (WDG), Oil dispersion (OD), Suspension concentrate (SC), or Suspoemulsion (SE) formulation. Yet another object of the present invention is to provide a synergistic herbicidal composition comprising pyroxasulfone; sulfentrazone; at least one additional herbicide selected from clomazone, diclosulam and flumioxazin; and one or more inactive excipient (s) which improve the yield and plant vigour of the treated plant. SUMMARY OF THE INVENTION Accordingly, the present invention provides a synergistic herbicidal composition comprising pyroxasulfone; sulfentrazone; and at least one additional herbicide selected from clomazone, diclosulam and flumioxazin. In one aspect, the present invention provides a synergistic herbicidal composition comprising: a) pyroxasulfone; b) sulfentrazone; c) at least one additional herbicide selected from clomazone, diclosulam and flumioxazin; and d) one or more inactive excipient(s). In another aspect, the present invention provides a process for preparing said synergistic herbicidal composition comprising: a) pyroxasulfone; b) sulfentrazone; c) at least one additional herbicide selected from clomazone, diclosulam and flumioxazin; and d) one or more inactive excipient(s) 5 Classification | PI External In another aspect, the present invention provides a method of selectively controlling undesirable vegetation in a monocot or dicot crops selected from the group consisting of wheat, peanut, soybean and sugarcane crop comprising applying an effective amount of herbicidal composition comprising a) pyroxasulfone; b) sulfentrazone; c) at least one additional herbicide selected from clomazone, diclosulam and flumioxazin; and d) one or more inactive excipient(s) to the locus of such vegetation. In yet another aspect, the present invention provides a synergistic herbicidal composition comprising: a) pyroxasulfone; b) sulfentrazone; c) at least one additional herbicide selected from clomazone, diclosulam and flumioxazin; and d) one or more inactive excipient(s), wherein the said composition is in the wettable power (WP), water dispersible granules (WDG), Oil dispersion (OD), Suspension concentrate (SC), or Suspoemulsion (SE) formulation. DETAILED DESCRIPTION OF THE INVENTION All technical and scientific terms used herein have the same meaning as commonly understood by one ordinary skilled in the art to which the invention pertains. The following definitions are provided for clarity. "Effective amounts” as mentioned herein means that amount which, when applied for treatment of crops, is sufficient to effect such treatment. As used herein, the term “improved” or “better” can be used interchangeably. “better effectiveness” as mentioned herein means the ability of active substances in the composition to produce a better result, one that delivers more value or achieves a better outcome in the observable effect on growth, including the effects of necrosis, death, retardation, prevention, and removal, destruction, or otherwise diminishing the occurrence and activity of the target organism. As used herein, the term “locus" means a plant, plant parts, plant propagation material (preferably seed), soil, area, material or environment in which a pest is growing or may grow. The locus includes the vicinity of desired crop plants wherein the pest infestation either has emerged or is yet to emerge. The term crop shall include a multitude of desired crop plants or an individual crop plant growing at a locus. 6 Classification | PI External The term “lower” or “minimal” or “minimum” as used herein can be used interchangeably and refers to the optimum concentration of active or inactive ingredients of formulation to achieve the expected efficacy. Unless otherwise specified, % refers to % weight; and % weight refers to % of the weight of the respective component with respect to the total weight of the composition. The term “formulation”, “mixture” and “composition” as used herein conveys the same meaning and can be used interchangeably. As used herein, the term “inactive excipient(s)” or "other inactive excipient(s)" can be used interchangeably and refers to inert substances which are commonly used to increase the activity profile of the composition or formulation with or without having agrochemical activity. Surfactants (also called surface active agents) are organic chemicals that reduce surface tension in water and other liquids. There are hundreds of compounds that can be used as surfactants. These compounds are usually classified by their ionic behavior in solutions: anionic, cationic, non-ionic or amphoteric (zwitterionic). Each surfactant class has its own specific physical, chemical, and performance properties. Surfactants are compounds composed of both hydrophilic and lipophilic groups. In view of their dual hydrophilic and lipophilic nature, surfactants tend to concentrate at the interfaces of aqueous mixtures; the hydrophilic part of the surfactant orients itself towards the aqueous phase and the lipophilic part orients itself away from the aqueous phase into the second phase. The lipophilic part of a surfactant molecule is generally derived from a hydrocarbon containing 8 to 20 carbon atoms (e.g. fatty acids, paraffins, olefins, alkylbenzenes). The hydrophilic portion may either ionize in aqueous solutions (cationic, anionic) or remain unionized (non-ionic). Surfactants and surfactant mixtures may also be amphoteric or zwitterionic. The terms “dispersing agents”, “wetting agents” and “emulsifying agents” as used in the present invention, are surfactants performing specific functions in a formulation. A surfactant may perform more than one function in a formulation. The term “adjuvant” is as inert ingredients which can enhance the biological performance of the active ingredient by facilitating penetration or uptake into the plant or arthropod pest or by increasing resistance to wash-off in certain formulations. While such adjuvant properties are not essential, they are highly desirable. As used herein, the term “stabilizer(s)” refers to a substance capable of imparting resistance against physical or chemical deterioration or deformulation. 7 Classification | PI External As used herein, the term “defoaming agent(s)” refers to a chemical additive that reduces and hinders the formation of foam in the industrial process liquids, semi-solids, or solids. The terms defoaming agent and anti-foaming agent can be used interchangeably. As used herein, the term “thickener(s)” refers to a polymeric material, which at a low concentration increases the viscosity of an aqueous solution and helps to stabilize the composition. The term "particle size" refers to the equivalent spherical diameter of a particle, i.e., the diameter of a sphere enclosing the same volume as the particle. "Median particle size" is the particle size corresponding to half of the particles being larger than the median particle size and half being smaller. With reference to particle size distribution, percentages of particles are also on a volume basis (e.g., "at least 95 % of the particles are less than about 25 microns" means that at least 95 % of the aggregate volume of particles consists of particles having equivalent spherical diameters of less than about 25 microns). The principles of particle size analysis are well known to those skilled in the art. which relies on the fact that the diffraction angle is inversely proportional to particle size. As used herein, the term “herbicide” shall mean an active ingredient that kills, controls or otherwise adversely modifies the growth of plants. As used herein, a herbicidally effective or vegetation controlling amount is an amount of active ingredient that causes a "herbicidal effect," i.e., an adversely modifying effect and includes deviations from natural development, killing, regulation, desiccation, retardation. The terms "plants" and "vegetation" include, but are not limited to, germinant seeds, emerging seedlings, plants emerging from vegetative propagules, and established vegetation. The present invention relates to a synergistic herbicidal composition of pyroxasulfone; sulfentrazone; and at least one additional herbicide selected from clomazone, diclosulam and flumioxazin. The synergistic herbicidal composition of the present invention advantageously exhibits better effectiveness with use of actives at minimum herbicidal application rate or concentration. A minimum application rate reduces not only the amount of an active substance required for the application but generally also reduces the amounts of formulation auxiliaries necessary. Both reduce the economic cost and improve the ecological compatibility of the herbicidal treatment. Moreover, synergism of the present invention reduces the number of applications of individual herbicidal components thus providing a cost-effective solution. In one embodiment, the present invention relates to a synergistic herbicidal composition comprising: a) pyroxasulfone; b) sulfentrazone; and 8 Classification | PI External c) at least one additional herbicide selected from clomazone, diclosulam and flumioxazin. In one embodiment, the present invention relates to a synergistic herbicidal composition comprising: a) pyroxasulfone; b) sulfentrazone; c) at least one additional herbicide selected from clomazone, diclosulam and flumioxazin; and d) one or more inactive excipient(s). In one embodiment, the present invention relates to a synergistic herbicidal composition comprising: a) pyroxasulfone; b) sulfentrazone; c) at least one additional herbicide selected from clomazone, diclosulam and flumioxazin; and d) one or more inactive excipient(s) selected from: i) surfactant and ii) other inactive excipient(s). The inventors of the present invention have surprisingly found that the compositions of the present invention i.e. combining pyroxasulfone and sulfentrazone with at least one additional herbicide selected from clomazone, diclosulam and flumioxazin provides: 1. First-rate control effect (Synergistic) that cannot be expected on the basis of the activities of the herbicidal compound used alone against undesired vegetation, 2. Increased spectrum of activity provides a solution for preventing the development of resistance, 3. Control of undesired vegetation for longer period as compared to the achievable compositions disclosed in prior arts, and 4. Surprisingly improved plant vigour and yield. Additionally, it has been observed visually that the plants with the treatment by combining pyroxasulfone and sulfentrazone with additional herbicide selected from clomazone, diclosulam and flumioxazin were showing increase in number of fruits, flowers, grain, tillers / shoots, and twigs per plant compared to standalone treatment plots of pyroxasulfone, sulfentrazone, clomazone, diclosulam and flumioxazin. In one preferred embodiment, the present invention provides the synergistic pesticidal composition comprising: a) 1% to 90% weight percentage of pyroxasulfone; b) 0.01% to 75% weight percentage of sulfentrazone; 9 Classification | PI External c) at least one additional herbicide selected from 0.01% to 50% weight percentage of clomazone, 0.01% to 50% weight percentage of diclosulam and 0.01% to 50% weight percentage of flumioxazin. In another preferred embodiment, the present invention provides the synergistic pesticidal composition comprising: a) 1% to 90% weight percentage of pyroxasulfone; b) 0.01% to 50% weight percentage of sulfentrazone; c) at least one additional herbicide selected from 0.01% to 50% weight percentage of clomazone, 0.01% to 50% weight percentage of diclosulam and 0.01% to 50% weight percentage of flumioxazin; and d) one or more inactive excipient(s); wherein the weight percentage % is based on the total weight of the composition. In accordance with an embodiment, one or more inactive excipient(s) is present in an amount in the range of 1% to 85% of the total weight of the composition, preferably from 10% to 70% of the total weight of the composition. In one embodiment, the present invention provides a composition wherein the amount of the active ingredient pyroxasulfone is in the range of 90gm-150gm per hector, sulfentrazone is in the range of 170gm to 750gm per hector, clomazone in the range of 200gm-460gm per hector flumioxazin in the range of 50gm-200gm and diclosulam in the range of 10gm - 35gm per hector. In another preferred embodiment, the present invention provides a composition wherein the amount of the active ingredient pyroxasulfone is in the range of 90gm-150gm per hector, sulfentrazone is in the range of 200gm to 350gm per hector, clomazone in the range of 230gm-400gm per hector flumioxazin in the range of 50gm-150gm and diclosulam in the range of 10gm - 25gm per hector. In accordance with an embodiment, one or more inactive excipient(s) may be selected from but not limited to dispersant or dispersing agents, fillers, wetting agents, suspension aid, anti-freezing agent, thickener, stabilizing agent, suspending agent, colorants, surfactants, pH regulators, anti-foaming agents, solvents, emulsifiers, solid carriers, oil(s) and preservative. In one embodiment other inactive excipient(s) may be selected from but not limited to additive(s), carrier(s), binder(s), antifreeze agent(s), stabilizer(s), anti-settling agent(s), thixotropic agent(s), preservative(s), glidant(s), solvent(s), water soluble polymer(s), crystallization inhibitor(s), viscosity modifier(s), suspending agent(s), spray droplet modifier(s), spreading agent(s), compatibilizing agent(s), corrosion inhibitor(s), odorant(s), sequestering agent(s), adjuvant(s), disintegrating agent(s), 10 Classification | PI External penetration aid(s), pH adjuster(s), lubricant(s), sticking agent(s), thickener(s), filler(s), diluent(s), defoaming agent(s), solubilizer(s), antioxidant(s), antimicrobial agent(s), buffering agent(s), disintegrant(s), oil(s), and / or coloring agent(s) or combination thereof. In one embodiment, the surfactant comprises one or more of a wetting agent(s), a dispersing agent(s), emulsifying agent(s) or mixture thereof. In one embodiment, the surfactant according to the present invention comprises ionic surfactant, non- ionic surfactant or mixture thereof. Suitable surfactants are surface-active compounds, for instance such as anionic, cationic, nonionic and amphoteric surfactants, block polymers, polyelectrolytes, and mixtures thereof. Such surfactants can be used as emulsifier, dispersant, solubilizer, wetter, penetration enhancer, protective colloid, or adjuvant. Suitable anionic surfactants are for instance alkali, alkaline earth or ammonium salts of sulfonates, sulphates, phosphates, carboxylates, and mixtures thereof. Examples of sulfonates are alkylaryl sulfonates, diphenyl sulfonates, alpha-olefin sulfonates, lignin sulfonates, sulfonates of fatty acids and oils, sulfonates of ethoxylated alkylphenols, sulfonates of alkoxylated arylphenols, sulfonates of condensed naphthalenes, sulfonates of dodecyl-and tridecylbenzenes, sulfonates of naphthalenes and alkyl naphthalenes, sulfosuccinates or sulfosuccinamates. Examples of sulphates are sulphates of fatty acids and oils, of ethoxylated alkylphenols, of alcohols, of ethoxylated alcohols, or of fatty acid esters. Examples of phosphates are phosphate esters. Examples of carboxylates are alkyl carboxylates, and carboxylated alcohol or alkylphenol ethoxylates. Suitable nonionic surfactants are for instance alkoxylates, N-substituted fatty acid amides, amine oxides, esters, sugar-based surfactants, polymeric surfactants, and mixtures thereof. Examples of alkoxylates are compounds such as alcohols, alkylphenols, amines, amides, arylphenols, fatty acids or fatty acid esters which have been alkoxylated with 1 to 50 equivalents. Ethylene oxide and / or propylene oxide may be employed for the alkoxylation, preferably ethylene oxide. Examples of N-substituted fatty acid amides are fatty acid glucamides or fatty acid alkanolamides. Examples of esters are fatty acid esters, glycerol esters or monoglycerides. Examples of sugar-based surfactants are sorbitans, ethoxylated sorbitans, sucrose and glucose esters or alkylpolyglucosides. Examples of polymeric surfactants are homo- or copolymers of vinyl pyrrolidone, vinyl alcohols, or vinyl acetate. Suitable cationic surfactants are for instance quaternary surfactants, for example quaternary ammonium compounds with one or two hydrophobic groups, or salts of long-chain primary amines. Suitable amphoteric surfactants are for instance alkylbetains and imidazolines. Suitable block polymers are 11 Classification | PI External block polymers of the A-B or A-B-A type comprising blocks of polyethylene oxide and polypropylene oxide, or of the A-B-C type comprising alkanol, polyethylene oxide and polypropylene oxide. Suitable polyelectrolytes are polyacids or polybases. Examples of polyacids are for instance alkali salts of polyacrylic acid or polyacid comb polymers. Examples of polybases are polyvinyl amines or polyethylene amines. Suitable adjuvants are compounds, which have a negligible or even no pesticidal activity themselves, and which improve the biological performance of the compound of Formula (I) on the target. Examples are surfactants, mineral or vegetable oils, and other auxiliaries. Suitable thickeners are for instance polysaccharides (e. g. xanthan gum, carboxymethyl cellulose), inorganic clays (organically modified or unmodified), polycarboxylates, and silicates. Suitable bactericides are for instance bronopol and isothiazolinone derivatives such as alkylisothiazolinones and benzisothiazolinones. Suitable anti-freezing agents are for instance ethylene glycol, propylene glycol, urea and glycerin. Suitable anti-foaming agents are silicones, long chain alcohols, and salts of fatty acids. Suitable colorants (e. g. in red, blue, or green) are for instance pigments of low water solubility and water-soluble dyes. Examples are inorganic colorants (e. g. iron oxide, titan oxide, iron hexacyanoferrate) and organic colorants (e. g. alizarin-, azo- and phthalocyanine colorants). Suitable tackifiers or binders are for instance polyvinyl pyrrolidones, polyvinyl acetates, polyvinyl alcohols, polyacrylates, biological or synthetic waxes, and cellulose ethers. Suitable solvents and liquid carriers in this context are for instance water and organic solvents, such as mineral oil fractions of medium to high boiling point, e. g. kerosene, diesel oil, oils of vegetable or animal origin; aliphatic, cyclic and aromatic hydrocarbons, e. g. toluene, paraffin, tetrahydronaphthalene, alkylated naphthalenes; alcohols, e. g. ethanol, propanol, butanol, benzyl alcohol, cyclohexanol; glycols; dimethyl sulfoxide; ketones, e. g. cyclohexanone; esters, e. g. lactates, carbonates, fatty acid esters, gamma-butyrolactone; fatty acids; phosphonates; amines; amides, e. g. N- methyl pyrrolidone, fatty acid dimethyl amides; and mixtures thereof. Suitable solid carriers or fillers are for instance mineral earths, e. g. silicates, silica gels, talc, kaolins, limestone, lime, chalk, clays, dolomite, diatomaceous earth, bentonite, calcium sulphate, magnesium sulphate, magnesium oxide; polysaccharides, e. g. cellulose, starch; fertilizers, e. g. ammonium sulphate, ammonium phosphate, ammonium nitrate, ureas; products of vegetable origin, e. g. cereal meal, tree bark meal, wood meal, nutshell meal, and mixtures thereof. In one embodiment, one or more inactive excipient(s) comprises oil(s) selected from but not limited to paraffin oil, vegetable oils, ethoxylated vegetable oil, methylated vegetable oil, epoxydized vegetable 12 Classification | PI External oil, hydrogenated vegetable oil, methylated seed oils, epoxidized oils, reconstituted oils or a mixture thereof. The combination ratio of pyroxasulfone, sulfentrazone and at least one additional herbicide selected from clomazone, diclosulam and flumioxazin depends on various factors such as, the undesired, vegetation to be controlled, the degree of infestation, the climatic conditions, the characteristics of the soil and the application method, wherein ratio of pyroxasulfone to sulfentrazone to at least one additional herbicide selected from clomazone, diclosulam and flumioxazin is from 100:0.25:0.25 to 0.25:100:0.25 to 0.25:0.25:100, preferably from 75:0.25:0.25 to 0.25:75:0.25 to 0.25:0.25:75, or preferably from 50:0.25:0.25 to 0.25:50:0.25 to 0.25:0.25:50, more preferably from 25:0.25:0.25 to 0.25:25:0.25 to 0.25:0.25:25, even more preferably from 10:0.25:0.25 to 0.25:10:0.25 to 0.25:0.25:10, most preferably from 5:0.25:0.25 to 0.25:5:0.25 to 0.25:0.25:5, even most preferably from 3.5:0.25:0.25 to 0.25:3.5:0.25 to 0.25:0.25:3.5. The synergistic pesticidal composition of the present invention may be formulated in the forms given below: Wettable powder (WP), Water-soluble granule (SG), Soluble concentrate (SL), Water soluble powder (SP), Water dispersible granule (WG or WDG), Water dispersible powder for slurry treatment (WS), a water dispersible tablet (WT), Water-soluble tablets (ST), an ultra-low volume (ULV) liquid (UL), an ultra-low volume (ULV) suspension (SU), Capsule suspension (CS), Dispersible concentrate (DC), Powder for dry seed treatment (DS), Emulsifiable concentrate (EC), Emulsion, water in oil (EO), Emulsion, oil in water (EW), Emulsion for seed treatment (ES), Flowable suspension / concentrate for seed treatment (FS), Granule / soil applied (GR), Controlled (Slow or Fast) release granules (CR) Solution for seed treatment (LS), Micro-emulsion (ME), Oil dispersion (OD), Oil miscible Flowable concentrate (oil miscible suspension (OF), Oil miscible liquid (OL), Suspension concentrate (Flowable concentrate) (SC), Suspo-emulsion (SE), A mixed formulation of CS en SC (ZC), A mixed formulation of CS en SE (ZE), A mixed formulation of CS en EW (ZW). In a preferred embodiment, the formulation is selected from Oil dispersion (OD), Suspension concentrate (Flowable concentrate) (SC), Suspo-emulsion (SE), Water dispersible granule (WG or WDG), Water-soluble granule (WG), or Wettable powder (WP). In another aspect, the present invention provides a process for preparing said synergistic herbicidal composition comprising: a) pyroxasulfone; b) sulfentrazone; c) at least one additional herbicide selected from clomazone, diclosulam and flumioxazin; and 13 Classification | PI External d) one or more inactive excipient(s) In another aspect, the present invention provides a process for preparing said synergistic herbicidal composition comprising: a) pyroxasulfone; b) sulfentrazone; c) at least one additional herbicide selected from clomazone, diclosulam and flumioxazin; and d) one or more inactive excipient(s) In another embodiment, the present invention provides a composition, comprises: (a) pyroxasulfone in the range of 10 to 50 % (w / w); (b) sulfentrazone in the range of 15 to 50 % (w / w); (c) clomazone, in the range of 10 to 50 % (w / w); (d) a surfactant selected from: i. a wetting agent in the range of 2 to 10 % (w / w); ii. a dispersing agent in the range of 3 to 15 % (w / w); (e) other excipients in the range of 30 to 70 % (w / w); wherein the total of all the components (a) to (e) in the composition is 100 % (w / w). In another embodiment, the present invention provides a composition, which comprises: (a) pyroxasulfone in the range of 10 to 50 % (w / w); (b) sulfentrazone in the range of 15 to 50 % (w / w); (c) diclosulam and flumioxazin in the range of 0.5 to 15 % (w / w); (d) a surfactant selected from: i. a wetting agent in the range of 3 to 7 % (w / w); ii. a dispersing agent in the range of 3 to 5 % (w / w); (e) other excipients in the range of 30 to 70 % (w / w); wherein the total of all the components (a) to (e) in the composition is 100 % (w / w). In another embodiment, the present invention provides a composition, which comprises: (a) pyroxasulfone in the range of 10 to 50 % (w / w); (b) sulfentrazone in the range of 15 to 50 % (w / w); (c) flumioxazin in the range of 5 to 30 % (w / w); (d) a surfactant selected from: i. a wetting agent in the range of 3 to 7 % (w / w); ii. a dispersing agent in the range of 3 to 5 % (w / w); 14 Classification | PI External (e) other excipients in the range of 30 to 70 % (w / w); wherein the total of all the components (a) to (e) in the composition is 100 % (w / w). In one embodiment, the combination ratio of pyroxasulfone, sulfentrazone and at least one additional herbicide selected from clomazone, diclosulam and flumioxazin is from 100:1:1 to 1:100:1 to 1:1:100. In one embodiment, the combination ratio of pyroxasulfone, sulfentrazone and at least one additional herbicide selected from clomazone, diclosulam and flumioxazin is from 50:1:1 to 1:50:1 to 1:1:50. In one embodiment, the combination ratio of pyroxasulfone, sulfentrazone and at least one additional herbicide selected from clomazone, diclosulam and flumioxazin is from 25:1:1 to 1:25:1 to 1:1:25. In one embodiment, the combination ratio of pyroxasulfone, sulfentrazone and at least one additional herbicide selected from clomazone, diclosulam and flumioxazin is from (1-15):(2-50):(1-2). In one embodiment, the combination ratio of pyroxasulfone, sulfentrazone and at least one additional herbicide selected from clomazone, diclosulam and flumioxazin is from (1-12):(2-25):(1-2). In one embodiment the particle size of the active ingredient in the composition is less than 20 microns. In one embodiment, the present invention provides a suspension concentrate (SC) formulation comprising pyroxasulfone; sulfentrazone; and at least one additional herbicide selected from clomazone, diclosulam and flumioxazin; a surfactant selected from EO / PO bock copolymer; acrylic graft copolymer; lignin sulfonates; silicone compound; 1,2- benzisothiazoline-3-one; 1,2-Propylene glycol; and xanthan gum water. In another embodiment, the present invention provides a wettable granule or water dispersible (WG) formulation comprising pyroxasulfone; sulfentrazone; and at least one additional herbicide selected from clomazone, diclosulam and flumioxazin; lignin sulfonates; sodium alkyl naphthalene sulfonate blend, silicone antifoam, solid carrier or filer, and water. In another embodiment, the present invention provides an oil dispersion (OD) formulation comprising pyroxasulfone; sulfentrazone; and at least one additional herbicide selected from clomazone, diclosulam and flumioxazin; high molecular weight polymeric emulsifier and dispersant; fatty alcohol ethoxylate; polydimethyl siloxane; anionic surfactant, stabiliser, and oil as carrier. In another embodiment, the present invention provides a Wettable powder (WP), formulation comprising pyroxasulfone; sulfentrazone; and at least one additional herbicide selected from 15 Classification | PI External clomazone, diclosulam and flumioxazin; lignin sulfonates; sodium alkyl naphthalene sulfonate blend, solid carrier or filer, and water. In yet another embodiment, the present invention relates to a method of preparing a stable, less toxic formulation of the present invention. In yet another embodiment, the present invention provides a method for the preparation of a water dispersible granule (WG) composition according to the above embodiments is provided, comprising the steps of: A) all the ingredients, as illustrated in table-1, except wetting agent, defoamer and water, were sieved, mixed, and milled to obtain a fine powder, wherein the particle size is less than 20 microns (Dv90, 90% w / w of the product is below 20 microns size); B) thereafter a solution of wetting agent, and defoamer in water was added to the powder obtained in step (A) and mixed to obtain a homogeneous extrudable mixture; and C) the extrudable mixture was extruded to obtain strings, which were then cut into shapes of granules; and dried. In another embodiment, the present invention provides an alternative method for the preparation of a water dispersible granule (WG) composition according to the above embodiments is provided, comprising the steps of: A) all the ingredients, as illustrated in table-1, except wetting agent, defoamer and water, were sieved, mixed, and milled to obtain a fine powder, wherein the particle size is less than 20 microns (Dv90, 90% w / w of the product is below 20 microns size); B) thereafter a solution of wetting agent, and defoamer in water was added to the powder obtained in step (a) and mixed to obtain a homogeneous slurry this slurry was passed through wet mill to further reduce the particle size below 20 microns; and C) the prepared slurry in step b was spray dried to obtain granules; and dried. In another embodiment, a method for the preparation of the suspension concentrate (SC) composition according to the above embodiments is provided, comprising the steps of: A) preparing an aqueous slurry of anti-freezing agent, wetting agent, dispersing agent, biocide, defoamer and water; B) adding all active ingredients to form an aqueous slurry; C) wet milling the slurry obtained from step (b) to get wet milled slurry; D) adding viscosity modifying agents and thickeners to the wet milled slurry; and 16 Classification | PI External E) stirring the mixture to obtain a suspension concentrate composition. In an embodiment, the present invention provides a Water dispersible granule composition of Pyroxasulfone + Sulfentrazone + Diclosulam. Composition-1: Pyroxasulfone + Sulfentrazone + Diclosulam (WG) Function Ingredients Qty. % w / w Active ingredient Pyroxasulfone 18.2 Active ingredient Sulfentrazone 40 Active ingredient Diclosulam 2.23 Dispersing agentsodium salt of naphthalene sulfonate condensate 4dispersant sodium lignosulfonate8wetting agent Anionic Tristyryphenol Ethoxylate Sulphate3Hydrophobic Filler Clay containing magnesium silicate 3 QS(Filer) Filer Q.S. 100 In another embodiment the present invention provides a Water dispersible granule composition(formulation) of Pyroxasulfone + Sulfentrazone + Flumioxazin. Composition-2: Pyroxasulfone + Sulfentrazone+ Flumioxazin (WG) Function Ingredients Qty. % w / w Active ingredient Pyroxasulfone 35.00 Active ingredient Sulfentrazone 15.94 Active ingredient Diclosulam 12.50 Dispersing agent Sodium lignosulfonate. 8.00 Dispersing agent Sodium salt of naphthalene sulfonate condensate 5.00 Wetting agent Alkyl naphthalene sulfonate. 4.00 Defoamer Silicone antifoam emulsion 0.10 Filler Mineral kaolinite QS 100.00In another preferred embodiment, the formulation is a liquid composition(formulation) selected from Suspension concentrate (Flowable concentrate) (SC). In an embodiment the present invention provides a Suspension concentrate (Flowable concentrate) (SC) composition of Pyroxasulfone + Sulfentrazone + Diclosulam. Composition-3: Pyroxasulfone + Sulfentrazone + Diclosulam (SC) Function Ingredients Qty. % w / w Active ingredient Pyroxasulfone 10.9 17 Classification | PI ExternalActive ingredientSulfentrazone 24Active ingredient Diclosulam 1.34 dispersant / wetting agent. Polyoxyethylene alkyl ether (NPE-free) 3 dispersing agent methyl acrylate polymer 5 dispersing agentsodium lignosulfonate1Antifreezing agent Propylene Glycol 10 20% aqueous propylene glycol Biocide solution of 1,2-benzisothiazolin-3-one. 0.12 foam control agentsilicone compound0.5Rheology modifier polysaccharide 0.12 Filer Diluent Q.S. 100 In an embodiment the present invention provides a Suspension concentrate (Flowable concentrate) (SC) composition of Pyroxasulfone + Sulfentrazone + Flumioxazin. Composition-4: Pyroxasulfone + Sulfentrazone + Flumioxazin (SC) Function IngredientsQty. (% w / v)Active ingredient Pyroxasulfone 12.75 Active ingredient Sulfentrazone 28.00 Active ingredient Flumioxazin 10.00 dispersant / wetting agent. Polyoxyethylene alkyl ether (NPE-free) 3.00 dispersing agent methyl acrylate polymer 5.00 dispersing agent sodium lignosulfonate 1.00 Antifreezing agent Propylene Glycol 10.00 Biocide 20% aqueous propylene glycol solution of 1,2-benzisothiazolin-3-one. 0.12 foam control agent silicone compound 0.50 Rheology modifier polysaccharide 0.12 Filer Diluent Q.S. 100.00In an embodiment the present invention provides an oil dispersion (OD) composition(formulation) of Pyroxasulfone + Sulfentrazone + Flumioxazin. Composition-5: Pyroxasulfone + Sulfentrazone + Flumioxazin (OD) Function Ingredients Qty. % w / w Active Ingredient Pyroxasulfone 11.2 Active Ingredient Sulfentrazone 24.6 Active Ingredient Flumioxazin 8.8 high molecular weight polymeric Sorbitol base, ethylene oxide (EO), emulsifier and dispersant and a polymerized fatty acid. 4 Emulsifier Fatty alcohol ethoxylate 4 18 Classification | PI External Polyoxythylene polyaryl phenol phospha 3 Emulsifier te, ammonium salt Antifoam Polydimethyl siloxane 0.5 Stabilizer Bentonite clay 1 Rheology modifier polyester block co-polymer 0.6 Carrier Vegetable Oil QS to make 100 Total 100 In another embodiment, the present invention relates to a method of selectively controlling undesirable vegetation in a monocot or dicot crops selected from the group consisting of peanut, soybean and sugarcane crop comprising applying an effective amount of herbicidal composition comprising a) Pyroxasulfone; b) Sulfentrazone; c) at least one additional herbicide selected from clomazone, diclosulam and flumioxazin; and d) one or more inactive excipient(s) to the locus of such vegetation. The method of application of the synergistic herbicidal composition of the present invention includes soil application, foliar spray, seed treatment or treatment to planting materials, and the application by drone. The synergistic herbicidal composition of the present invention may be used to protect the crops and plants from undesirable vegetation. The lists of the major crops include but are not limited to GMO (Genetically Modified Organism) and Non-GMO varieties of, including but not limited to, Cotton (Gossypium spp.), Paddy (Oryza sativa), Wheat (Triticum aestavum), Barley (Hordeum vulgare), Maize (Zea mays), Sorghum (Sorghum bicolor), Oat (Avena sativa), Pearl millet (Pennisetum glaucum), Sugarcane (Saccharum officinarum), Sugarbeet (Beta vulgaris), Soybean (Glycin max), Peanut (Arachis hypogaea), Sunflower (Helianthus annuus), Mustard (Brassica juncea), Rape seed (Brassica napus), Linseed (Linum usitatissimum), Sesame (Sesamum indicum), Green gram (Vigna radiata), Black gram (Vigna mungo), Chickpea (Cicer aritinum), Cowpea (Vigna unguiculata), Redgram (Cajanus cajan), Frenchbean (Phaseolus vulgaris), Indian bean (Lablab purpureus), Horse gram (Macrotyloma uniflorum), Field pea (Pisum sativum), Cluster bean (Cyamopsis tetragonoloba), Lentils (Lens culinaris), Brinjal (Solanum melongena), Cabbage (Brassica oleracea var. capitata), Cauliflower (Brassica oleracea var. botrytis), Okra (Abelmoschus esculentus),Onion (Allium cepa L.),Tomato (Solanum lycopersicun), Potato (Solanum tuberosum), Sweet potato (Ipomoea batatas), Chilly (Capsicum annum), Garlic (Allium sativum), Cucumber (Cucumis sativus), Muskmelons (Cucumis melo), Watermelon (Citrullus lanatus), Bottle gourd (Lagenaria siceraria), Bitter gourd (Momordica charantia), Radish (Raphanus sativus), Carrot (Dacus carota subsp. sativus), Turnip (Brassica rapasubsprapa), Apple (Melus domestica), Banana (Musa spp.), Citrus groups (Citrus spp.), Grape 19 Classification | PI External (Vitis vinifera), Guava (Psidium guajava), Litchi (Litchi chinensis), Mango (Mangifera indica), Papaya (Carica papaya), Pineapple (Ananas comosus), Pomegranate (Punica granatum), Sapota (Manilkara zapota), Tea (Camellia sinensis), Coffea (Coffea Arabica), Turmeric (Curcuma longa), Ginger (Zingiber officinale), Cumin (Cuminum cyminum), Fenugreek (Trigonella foenum-graecum), Fennel (Foeniculum vulgare), Coriander (Coriandrum sativum), Ajwain (Trachyspermum ammi), Psyllium (Plantago ovate), Black Pepper (Piper nigrum), Stevia (Stevia rebaudiana), Safed musli (Chlorophytum tuberosum), Drum stick (Moringa oleifera), Coconut (Coco nucifera), Mentha ( Mentha spp.), Rose (Rosa spp.), Jasmine (Jasminum spp.), Marigold (Tagetes spp.), Common daisy (Bellis perennis), Dahlia (Dahlia hortnesis), Gerbera (Gerbera jamesonii), or Carnation (Dianthus caryophyllus). The synergistic herbicidal composition of the present invention may be used for the control of the growth, proliferation or germination of undesired plants or weeds. In an embodiment, the synergistic herbicidal composition of the present invention controls all kinds of monocots, dicots and sedges, grassy and broad leaf weeds. The synergistic herbicidal composition also controls annual, Biennials and perennial weeds. The most common weeds controlled by the composition include, but are not limited to, Abutilon indicum, Acalyphaindica, Acanthospermumhispidum, Achyranthes aspera, Aervatomentosa, Ageratum conyzoides, Alhagicamelorum, Amaranthus hybridus, Amaranthus spinosus, Amaranthus viridis, Ammanniabaccifera, Anagallis arvensis, Argemone mexicana, Artemisia nilagiricia, Asphodelus tenuifolius, Avenafatua, Avenaludoviciana, Bidens pilosa, Boerhaaviadiffusa, Boerhaviarepanda, Brachiariamutica, Brassica kaber, Bromus tectorum, Calotropis gigantea, Cannabis sativa, Carthamusaxyacantha, Cassia tora, Celosia argentea, Centellaasiatica, Chenopodium album, Chenopodium murale, Chloris barbata, Chrozophorarottlerii, Cichoriumintybus, Cirsium arvense, Clitoriaternatea, Cnicus arvensis, Commelinabenghalensis, Commelinacommunis, Convolvulus arvensis, Conyza canadensis, Corchorus acutangulus, Coronopusdidymus, Crotalaria serice, Cucumis callosus, Cuscuta campestris, Cuscutachinensis, Cynodondactylon, Cyanotisaxillaris, Cyperusesculenthus, Cyperusiria, Cyperusrotundus, Dactylocteniumaegyptium, Datura stramonium, Daucus carota, Digera arvensis, Digitariasanguinalis, Dinebraretroflexa, Echinocholacolonum, Echinocholacrusgalli, Eclipta alba, Eichhorniacrassipes, Elephantopusscaber, Eleusineindica, Eragrostis major, Euphorbia geniculata, Euphorbia hirta, Fimbristylismiliacea, Fumaria indica, Gynandropsisgynandra, Heliotropiumindicum, Indigoferaglandulosa, Ipomeaaquatica, Lantana camara, Lathyrus aphaca, Launaeaasplenifolia, Launaeanudicaulis, Leucas aspera, Ludwigia parviflora, Marsileaquadrifoliata, Medicago denticulate, Mimosa pudica, Melilotus alba, Melilotusindica, Ocimumcanum, Oenothera biennis, Opuntia dillenil, Orobancheramosa, Oryza longistaminata, Oryza sativa, Oxalis corniculata, Oxalis latifolia, Parthenium hysterophorus, Paspalumsanguinale, Phalaris minor, Phyllanthus niruri, Physalis minima, Polypogonmonspeliensis, Portulaca oleracea, Prosopis juliflora, Rumexdentatus, Saccharum 20 Classification | PI External spontaneum, Stearia glauca, Seteria viridis, Sida spinosa, Silene antirrhina, Sisymbriumirio, Solanum nigrum, Solanum surattense, Sonchusoleraceous, Sorghum halepense, Spergula arvensis, SphenocleazeylanicaGaertn, Striga asiatica, Tagetes minuta, Trianthemamonogyna, Trianthemaportulacastrum, Tribulus terrestris, Trigoneliapolycerata, Vernonia cinerea, Vicia sativa, Xanthium strumarium and the like. In a preferred embodiment, the synergistic herbicidal composition according to the present invention for the control of the growth, proliferation or germination of undesired plants or weeds selected from Acalypha indica, Brachiaria spp., Brachiaria ramose, Commelina benghalensis, Commelina communis, Digera arvensis, Dinebra retroflexa Digiteria sanguinalis Echinochloa colona Euphorbia geniculate, Impatiens balsemina or Ipomea indica. The synergistic herbicidal composition of the present invention may be effective in the control of undesired vegetation in plantation crops, orchards, fallow lands, water bodies, and field bunds. In a preferred embodiment, the synergistic herbicidal composition according to the present invention to to protect the crops and plants from undesirable vegetation wherein the crops are wheat, sugarcane, peanut, and soybean. The composition of the present invention maybe applied simultaneously as a tank mix or a formulation or may be applied sequentially or premix. The application may be made to the soil before emergence of the plants, either pre-planting or post-planting. The application may be made as a foliar spray at different timings during crop development, with either one or two applications early or late post- emergence. The compositions according to the invention can be applied before or after invading of the useful plants by the undesired vegetation, weeds or grasses. In one embodiment, the present invention provides the premix composition comprising of pyroxasulfone, sulfentrazone at least one of clomazone, diclosulam or flumioxazin and at least one auxiliary. In one embodiment, the present invention provides a solution for managing problematic weeds such as Acalypha indica, Brachiaria spp., Brachiaria ramosa, Commelina benghalensis, Commelina communis, Digera arvensis, Dinebra retroflexa, Digitaria sanguinalis, Echinochloa colona, Euphorbia geniculata, Impatiens balsamina and Ipomea indica, particularly in fields cultivated with preferred crops such as wheat, sugarcane, peanut, and soybean. 21 Classification | PI External The user may apply the synergistic pesticidal composition according to the invention usually from a predosage device, a knapsack sprayer, a spray tank, a spray plane, or an irrigation system. Usually, the pesticidal composition is made up with water, buffer, and / or further auxiliaries to the desired application concentration and the ready-to-use spray liquor or the pesticidal composition according to the invention is thus obtained. Usually, 20 to 2000 liters, preferably 30 to 400 liters, of the ready-to-use spray liquor are applied per hectare of agricultural useful area. According to one embodiment, individual components of the pesticidal composition according to the invention such as parts of a kit or parts of a binary or ternary mixture may be mixed by the user himself in a spray tank or any other kind of vessel used for applications (e. g. seed treater drums, seed pelleting machinery, knapsack sprayer) and further auxiliaries may be added, if appropriate. Consequently, one embodiment of the present invention is a kit for preparing a usable pesticidal composition, the kit comprising a) a composition comprising pyroxasulfone and at least one auxiliary; b) a composition comprising sulfentrazone and at least one auxiliary; and c) a composition comprising clomazone, diclosulam or flumioxazin and at least one auxiliary. The pesticidal composition of the present invention can also be used in combination with smart spraying equipment such as e.g. spot spraying or precision spraying equipment attached to or housed within a farm vehicle such as a tractor, robot, helicopter, airplane, unmanned aerial vehicle (UAV) such as a drone, etc. Such an equipment usually includes input sensors (such as e.g. a camera) and a processing unit configured to analyse the input data and provide a decision, based on the analysis of the input data, to apply the compound of the invention to the crop plants (respectively the weeds) in a specific and precise manner. The use of such smart spraying equipment usually also requires position systems (e.g. GPS receivers) to localize recorded data and to guide or to control farm vehicles; geographic information systems (GIS) to represent the information on intelligible maps, and appropriate farm vehicles to perform the required farm action such as the spraying. The process for preparing the composition of the present invention can be modified accordingly by any person skilled in the art based on the knowledge of the manufacturing the formulation. However, all such variation and modification is still covered by the scope of present invention. While the foregoing written description of the invention enables one of ordinary skill to make and use what is considered presently to be the best mode thereof, those of ordinary skill will understand and appreciate the existence of variations, combinations, and equivalents of the specific embodiment, method, and examples herein. The invention should therefore not be limited by the above described 22 Classification | PI External embodiment, method, and examples, but by all embodiments and methods within the scope and spirit of the invention. The field trials (Experiments mentioned below) were conducted using the compositions 1 to 5 as described herein above. Experiment 1: Weed control in Soybean: Location Mhow, MP Village Harsola District Indore Season Kharif 2024 Crop / Variety Soybean / JS- 2172 Target Grasses, BLW Plot Size 50 SQM Date of Sowing 23-06-2024 Date of Application 24-06-2024 Soil Type Black Soil Water Volume 500 L / ha Soil Type Black Soil Agronomic Practices: All the required agronomic practices were followed except herbicidal application. Observation Methods: Mixed weed flora – (Impatiens balsemina, Digera arvensis, Acalypha indica, Euphorbia geniculate, Dinebra retroflexa, Echinochloa colona, Brachiaria spp., Commelina benghalensis): Weed count was recorded at 21 DAA (Days after Application) by using (50 SqM) quadrant. The weed control (%) was calculated by using the formula Table 1: Treatment details: 21 days after application Treatment Treatment details Use / Dose rate g a.i. / h Observed Expected Synergy Number Efficacy efficacy 23 Classification | PI External 1.1 Pyroxasulfone + 127.5+ 280+15.6 97.76 89.9 1.08 Sulfentrazone + Diclosulam 1.2 Sulfentrazone + Diclosulam 360+26 80.90 81.31 0.99 1.3 Pyroxasulfone + Diclosulam 127.5+26 77.9 73.5 1.05 1.4 Pyroxasulfone + 127.5+360 81.87 79.41 1.03 Sulfentrazone 1.5 Diclosulam 26 50.98 1.6 Sulfentrazone 360 61.89 1.7 Pyroxasulfone 127.5 45.98 1.8 UTC (Untreated Check) / 0 0 Control Experiment 2: Weed control in Soybean: Agronomic Practices: All the required agronomic practices were followed except herbicidal application. Observation Methods: Mixed weed flora – (Impatiens balsemina, Digera arvensis, Acalypha indica, Euphorbia geniculate, Dinebra retroflexa, Echinochloa colona, Brachiaria spp., Commelina benghalensis): Weed count was recorded at 42 DAA (Days after Application) by using (50 SqM) quadrant. The weed control (%) was calculated by using the formula Table 2: Treatment details: 42 days after application Treatment Treatment details Use / Dose rate g a.i. / h Observed Expected Synergy Number Efficacy efficacy 2.1 Pyroxasulfone + 127.5+ 280+15.6 91.87 81.85 1.12 Sulfentrazone + Diclosulam 2.2 Sulfentrazone + Diclosulam 360+26 67.9 68.72 0.98 2.3 Pyroxasulfone + Diclosulam 127.5+26 63.98 62.21 1.02 2.4 Pyroxasulfone + 127.5+360 74.89 72.13 1.03 Sulfentrazone 2.5 Diclosulam 26 34.87 2.6 Sulfentrazone 360 51.9 2.7 Pyroxasulfone 127.5 41.98 2.8 UTC (Untreated Check) / 0 0 Control Experiment 3: Weed control and crop safety in Soybean (Commelina communis): 24 Classification | PI External Agronomic Practices: All the required agronomic practices were followed except herbicidal application. Observation Methods: Broad leaf weed – (Commelina communis): Weed count was recorded at 42 DAA (Days after Application) by using (50 SqM) quadrant. The weed control (%) was calculated by using the formula Table 3: Treatment details: 42 days after application Treatment Treatment details Use / Dose rate Observed Expected Synergy Number g a.i. / h Efficacy efficacy 3.1 Pyroxasulfone + Sulfentrazone 127.5+ 98.87 88.16 1.12 + Diclosulam 280+15.6 3.2 Sulfentrazone + Diclosulam 360+26 80.98 86.99 0.93 3.3 Pyroxasulfone + Diclosulam 127.5+26 53.05 52.65 1.0 3.4 Pyroxasulfone + Sulfentrazone 127.5+360 76.89 77.24 0.99 3.5 Diclosulam 26 47.98 3.6 Sulfentrazone 360 75 3.7 Pyroxasulfone 127.5 8.98 3.8 UTC (Untreated Check) / 0 0 Control Experiment 4: Weed control in Soybean: Location Indore (MP) Target Grasses, BLW Name of Farmer Dinesh Dethaliya Village Sanwer District Indore Season Kharif 2024 Crop / Variety Soybean / JS- 9560 Plot Size 25 SQM Date of Sowing 23-06-2024 Date of Application 24-06-2024 Water Volume 500 L / ha Application Method Soil application fitted with Flat Fan Nozzle 25 Classification | PI External Agronomic Practices: All the required agronomic practices were followed except herbicidal application. Observation Methods: Mixed weed flora – Commelina communis , Digera arvensis, Acalypha indica, Digiteria sanguinalis, Dinebra retroflexa, Echinochloa colona , Brachiaria ramose, Commelina benghalensis): Weed count was recorded at 21 DAA (Days after Application) by using (25 SqM) quadrant. The weed control (%) was calculated by using the formula Table 4: Treatment details: 21 days after application Treatment Treatment details Use / Dose rate g Observed Expected Synergy Number a.i. / h Efficacy efficacy 4.1 Pyroxasulfone + 127.5+280+100 97.76 88.20 1.11 Sulfentrazone + Flumioxazin 4.2 Sulfentrazone + 360+125 78.96 82.16 0.96 Flumioxazin 4.3 Pyroxasulfone + 127.5+125 67.89 65.53 1.03 Flumioxazin 4.4 Pyroxasulfone + 127.5+360 81.87 77.38 1.05 Sulfentrazone 4.5 Flumioxazin 125 47.87 4.6 Sulfentrazone 360 65.78 4.7 Pyroxasulfone 127.5 33.89 4.8 UTC (Untreated Check) / Control Experiment 5: Weed control in Soybean: Location Indore (MP) Target Grasses, BLW Name of Farmer Dinesh Dethaliya Village Sanwer District Indore Season Kharif 2024 Crop / Variety Soybean / JS- 9560 26 Classification | PI External Plot Size 25 SQM Date of Sowing 23-06-2024 Date of Application 24-06-2024 Water Volume 500 L / ha Application Method Soil application fitted with Flat Fan Nozzle Soil Type Black Soil Agronomic Practices: All the required agronomic practices were followed except herbicidal application. Observation Methods: 42 days after application Mixed weed flora – Commelina communis , Digera arvensis, Acalypha indica, Digiteria sanguinalis, Dinebra retroflexa, Echinochloa colona , Brachiaria ramose, Commelina benghalensis): Weed count was recorded at 42 DAA (Days after Application) by using (25 SqM) quadrant. The weed control (%) was calculated by using the formula Table 5: Treatment details: Treatment Treatment details Use / Dose rate Observed Expected Synergy Number g a.i. / h Efficacy efficacy 5.1 Pyroxasulfone + Sulfentrazone 127.5+280+100 95 78.29 1.21 + Flumioxazin 5.2 Sulfentrazone + Flumioxazin 360+125 68.8 70.35 0.97 5.3 Pyroxasulfone + Flumioxazin 127.5+125 52.9 53 0.99 5.4 Pyroxasulfone + Sulfentrazone 127.5+360 69 66.4 1.04 5.5 Flumioxazin 125 35.89 5.6 Sulfentrazone 360 53.76 5.7 Pyroxasulfone 127.5 26.78 5.8 UTC (Untreated Check) / 0 0 Control Experiment 6: Weed control and crop safety in Soybean (Impatiens balsamina & Euphorbia geniculata): Agronomic Practices: All the required agronomic practices were followed except herbicidal application. Observation Methods: 27 Classification | PI External Broad leaf weed flora – (Impatiens balsamina & Euphorbia geniculata): Weed count was recorded at 42 DAA (Days after Application) by using (25 SqM) quadrant. The weed control (%) was calculated by using the formula Table 6: Treatment details: 42 days after application Treatment Treatment details Use / Dose rate Observed Expected Synergy Number g a.i. / h Efficacy efficacy 6.1 Pyroxasulfone + Sulfentrazone 127.5+280+100 91.87 81.85 1.12 + Flumioxazin 6.2 Sulfentrazone + Flumioxazin 360+125 68.87 70.69 0.97 6.3 Pyroxasulfone + Flumioxazin 127.5+125 32.8 33.51 0.98 6.4 Pyroxasulfone + Sulfentrazone 127.5+360 66.8 67.23 0.99 6.5 Flumioxazin 125 22.89 6.6 Sulfentrazone 360 62 6.7 Pyroxasulfone 127.5 13.78 6.8 UTC (Untreated Check) / 0 0 Control Experiment 7: crop safety in Soybean: Study is conducted using the compositions-1 to 5 as described herein above. Agronomic Practices: All the required agronomic practices were followed except herbicidal application. Observation Methods: 42 days after application Mixed weed flora – (Acalypha indica, Brachiaria spp., Brachiaria ramose, Commelina benghalensis, Commelina communis, Digera arvensis, Dinebra retroflexa, Digiteria sanguinalis, Echinochloa colona, Euphorbia geniculate, Impatiens balsemina): Weed count was recorded at 42 DAA (Days after Application) by using 50 SqM and 25 SqM quadrant. Table 7: Treatment details: 42 days after application Treatment T Crop Number reatment details Dose (GAH) Phyto injury Rating 7.1 Pyroxasulfone 127.500% 0 7.2 Sulfentrazone 28021-10% 1 7.3 Flumioxazin 100111-20% 2 7.4 127.5+ 280+100021-30% 3 28 Classification | PI External Pyroxasulfone + Sulfentrazone + 31-40% 4 Flumioxazin 7.5 Pyroxasulfone + Sulfentrazone 127.5+280 2 41-50% 5 7.6 Pyroxasulfone + Flumioxazin 127.5+100 1 51-60% 6 7.7 Sulfentrazone + Flumioxazin 280+100 2 61-70% 7 7.8 Sulfentrazone+Clomazone ket standard) 35 2 (Mar 0+375 71-80% 8 Experiment 8: Weed control and crop safety in Sugarcane (Ipomea indica): Agronomic Practices: All the required agronomic practices were followed except herbicidal application. Observation Methods: Broad leaf weed – (Ipomea indica): Weed count was recorded at 42 DAA (Days after Application) by using (50 SqM) quadrant. The weed control (%) was calculated by using the formula Table 8: Treatment details: 42 days after application Treatment Treatment details Use / Dose rate Observed Expected Synergy Number g a.i. / h Efficacy efficacy 8.1 Pyroxasulfone + Sulfentrazone 127.5+ 97.98 81.34 1.2 + Diclosulam 280+15.6 8.2 Sulfentrazone + Diclosulam 360+26 73.90 79.94 0.92 8.3 Pyroxasulfone + Diclosulam 127.5+26 48.87 49.75 0.98 8.4 Pyroxasulfone + Sulfentrazone 127.5+360 64.95 65.46 0.99 8.5 Diclosulam 26 45.80 8.6 Sulfentrazone 360 62.87 8.7 Pyroxasulfone 127.5 7.0 8.8 UTC (Untreated Check) / 0 0 Control 29 Classification | PI External Having described the invention with reference to certain preferred embodiments, other embodiments will become apparent to one skilled in the art from consideration of the specification. 30 Classification | PI External

Claims

CLAIMS:

1. A synergistic herbicidal composition comprising: a. Pyroxasulfone; b. Sulfentrazone; and c. at least one additional herbicide selected from clomazone, diclosulam and flumioxazin.

2. The synergistic herbicidal composition as claimed in claim 1, wherein a) 1% to 90% weight percentage of pyroxasulfone; b) 0.01% to 75% weight percentage of sulfentrazone; c) at least one additional herbicide selected from 0.01% to 50% weight percentage of clomazone, 0.01% to 50% weight percentage of diclosulam and 0.01% to 50% weight percentage of flumioxazin.

3. The synergistic herbicidal composition as claimed in claim 1 or 2, wherein said composition further comprising: d) one or more inactive excipient(s).

4. The synergistic herbicidal composition as claimed in claim 3 wherein one or more inactive excipient(s) in said composition comprising: i) surfactant and ii) other inactive excipient(s).

5. The synergistic herbicidal composition as claimed in claim 4 wherein the surfactant comprises ionic surfactant, non-ionic surfactant or mixture thereof.

6. The synergistic herbicidal composition as claimed in claim 4 wherein the surfactant comprises ionic surfactant.

7. The synergistic herbicidal composition as claimed in claim 4 wherein the surfactant comprises non-ionic surfactant.

8. The synergistic herbicidal composition as claimed in claim 4 wherein the surfactant comprises one or more of a wetting agent(s), a dispersing agent(s), emulsifying agent(s) or mixture thereof.

9. The synergistic herbicidal composition as claimed in claim 4 wherein the other inactive excipient(s) is selected from additive(s), carrier(s), binder(s), antifreeze agent(s), stabilizer(s), anti-settling agent(s), thixotropic agent(s), preservative(s), glidant(s), solvent(s), water soluble 31 Classification | PI Externalpolymer(s), crystallization inhibitor(s), viscosity modifier(s), suspending agent(s), spray droplet modifier(s), spreading agent(s), compatibilizing agent(s), corrosion inhibitor(s), odorant(s), sequestering agent(s), adjuvant(s), disintegrating agent(s), penetration aid(s), pH adjuster(s), lubricant(s), sticking agent(s), thickener(s), filler(s), diluent(s), defoaming agent(s), solubilizer(s), antioxidant(s), antimicrobial agent(s), buffering agent(s), disintegrant(s), and / or coloring agent(s) or combination thereof.

10. The synergistic herbicidal composition as claimed in any of above claim, wherein a) 1% to 90% weight percentage of pyroxasulfone; b) 0.01% to 75% weight percentage of sulfentrazone; c) at least one additional herbicide selected from 0.01% to 50% weight percentage of clomazone, 0.01% to 50% weight percentage of diclosulam and 0.01% to 50% weight percentage of flumioxazin; and d) one or more inactive excipient(s); wherein the weight percentage % is based on the total weight of the composition.

11. A herbicidal formulation comprising a composition as claimed in any of the above claims 1 to 8 and at least one solid or liquid carrier.

12. The herbicidal formulation as claimed in any of above claim, wherein said composition is selected from Wettable powder (WP), Water-soluble granule (SG), Soluble concentrate (SL), Water soluble powder (SP), Water dispersible granule (WG or WDG), Water dispersible powder for slurry treatment (WS), a water dispersible tablet (WT), Water-soluble tablets (ST), an ultra-low volume (ULV) liquid (UL), an ultra-low volume (ULV) suspension (SU), Capsule suspension (CS), Dispersible concentrate (DC), Powder for dry seed treatment (DS), Emulsifiable concentrate (EC), Emulsion, water in oil (EO), Emulsion, oil in water (EW), Emulsion for seed treatment (ES), Flowable suspension / concentrate for seed treatment (FS), Granule / soil applied (GR), Controlled (Slow or Fast) release granules (CR) Solution for seed treatment (LS), Micro-emulsion (ME), Oil dispersion (OD), Oil miscible Flowable concentrate (oil miscible suspension (OF), Oil miscible liquid (OL), Suspension concentrate (Flowable concentrate) (SC), Suspo-emulsion (SE), A mixed formulation of CS en SC (ZC), A mixed formulation of CS en SE (ZE), A mixed formulation of CS en EW (ZW).

13. The synergistic herbicidal composition as claimed in claim 1, wherein ratio of pyroxasulfone to sulfentrazone to at least one additional herbicide selected from clomazone, diclosulam and flumioxazin is from 100:1:1 to 1:100:1 to 1:1:

100. 32 Classification | PI External14. The synergistic herbicidal composition as claimed in any of claims 1 to 13 for the control of the growth, proliferation or germination of undesired plants or weeds selected from Acalypha indica, Brachiaria spp., Brachiaria ramose, Commelina benghalensis, Commelina communis, Digera arvensis, Dinebra retroflexa Digiteria, sanguinalis, Echinochloa colona, Euphorbia geniculate, Impatiens balsemina or Ipomea indica.

15. The synergistic herbicidal composition as claimed in any of claims 1 to 14 to protect the crops and plants from undesirable vegetation, wherein the crops are wheat, sugarcane, peanut, and soybean.

16. A method for preparing said synergistic herbicidal composition comprising: a) pyroxasulfone; b) sulfentrazone; c) at least one additional herbicide selected from clomazone, diclosulam and flumioxazin; and d) one or more inactive excipient(s) 17. A method for controlling undesirable vegetation, which comprises allowing a composition as claimed in any of claims 1 to 13 to act on plants to be controlled or their habitat. 33 Classification | PI External

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