Combinations of BRAF and ALK / TRK inhibitors for colorectal cancer

Abstract

The present invention relates to combination therapies of a BRAF inhibitor and an ALK / TRK inhibitor, or their pharmaceutically acceptable salts, hydrates, or solvates thereof, and their use in the treatment of cancer, in particular colorectal cancer, including BRAF mutant colorectal cancer. Methods of treatment and methods of predicting whether a subject having colorectal cancer is likely to respond to treatment are also disclosed herein.

Description

[0001] COMBINATIONS OF BRAF AND ALK / TRK INHIBITORS FOR COLORECTAL CANCER

[0002] Field of the Invention

[0003] The invention relates to combination therapies for the treatment of cancer.

[0004] Background

[0005] Despite advances in treatment cancer continues to have a major impact on societies, families, and individuals across the world. Cancer is among the leading causes of death worldwide. According to statistics provided by the National Cancer Institute, in 2018 there were 18.1 million new cases and 9.5 million cancer-related deaths worldwide. By 2040 the number of new cancer cases per year is expected to rise to 29.5 million and the number of cancer-related deaths to 16.4 million.

[0006] The use of single-agent targeted therapies in patients with molecularly defined tumours is improving cancer treatment. Nonetheless, many patients still lack effective treatments and pre-existing or acquired resistance limits the clinical benefit of even our most advanced medicines. Combination therapies using the growing number of targeted anti-cancer agents have potential to overcome resistance, to enhance response to existing drugs, to reduce dose limiting single agent toxicity, and to expand the range of treatments for patients.

[0007] Gastrointestinal (Gl) cancers represent a particularly high unmet medical need; subtypes include colorectal, gastric, oesophageal, pancreatic, and liver cancer. Colorectal cancer is the most common form of Gl cancer. According to the World Health Organisation (July 2023), colorectal cancer is the third most- common cancer overall and the second-leading cause of cancer-related deaths worldwide. It is often diagnosed late and at an advanced stage of disease, when both treatment options and clinical outcomes are poor.

[0008] There is therefore a significant need for novel therapies targeting Gl cancers, in particular for late-stage and metastatic disease. The National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) Program reports a 5-year relative survival rate of just 15.7% for distant colorectal cancer in the USA (2016 figures). Similarly, the World Health Organisation’s International Cancer Benchmarking Partnership (ICBP)-SURVMARK-2 Program reports a 5-year net survival range of 8.1 - 18.1% for distant colorectal cancers across seven high-income countries, including the UK and Canada (2010 - 2014 figures).

[0009] Summary of the Invention

[0010] The invention is directed to the use of therapeutic combinations of active ingredients for the treatment of colorectal cancer in patients, and especially to the combination of a BRAF inhibitor and an ALK / TRK inhibitor, or their pharmaceutically acceptable salts, hydrates, or solvates thereof. As described herein, the inventors have observed synergy for combinations of a BRAF inhibitor and an ALK / TRK inhibitor in colorectal cancer cell lines.

[0011] In a first aspect, the invention provides a combination of a BRAF inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof) and an ALK / TRK inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof) for use in a method of treatment of colorectal cancer in a patient. In some embodiments, the invention provides a BRAF inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof) for use in a method of treatment of colorectal cancer in a patient, wherein the BRAF inhibitor is administered to a patient in combination with an ALK / TRK inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof). In some embodiments, the invention provides an ALK / TRK inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof) for use in a method of treatment of colorectal cancer in a patient, wherein the ALK / TRK inhibitor is administered to a patient in combination with a BRAF inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof).

[0012] In a related aspect, the invention provides a method of treatment of colorectal cancer, wherein the method comprises the step of administering a therapeutically effective amount of a combination of a BRAF inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof) and an ALK / TRK inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof) to a patient in need thereof. The invention also relates to a method of treatment of colorectal cancer, wherein the method comprises the step of administering a therapeutically effective amount of a BRAF inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof) to a patient in need thereof, wherein the BRAF inhibitor is administered to the patient in combination with an ALK / TRK inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof). The invention also relates to a method of treatment of colorectal cancer, wherein the method comprises the step of administering a therapeutically effective amount of an ALK / TRK inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof) to a patient in need thereof, wherein the ALK / TRK inhibitor is administered to the patient in combination with a BRAF inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof).

[0013] In a related aspect, the invention provides a use of a combination of a BRAF inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof) and an ALK / TRK inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof) for the manufacture of a medicament for the treatment of colorectal cancer in a patient. In some embodiments, the invention provides a use of a BRAF inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof) for the manufacture of a medicament for the treatment of colorectal cancer in a patient, wherein the BRAF inhibitor is administered to a patient in combination with an ALK / TRK inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof). In some embodiments, the invention provides a use of an ALK / TRK inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof) for the manufacture of a medicament for the treatment of colorectal cancer in a patient, wherein the ALK / TRK inhibitor is administered to a patient in combination with a BRAF inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof).

[0014] In a related aspect, the invention provides a method of predicting whether a subject having colorectal cancer is likely to respond to treatment with a combination of a BRAF inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof) and an ALK / TRK inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof), the method comprising determining the mutational status of BRAF gene in the colorectal cancer and selecting the subject for treatment if the BRAF gene is a BRAF mutant. In some embodiments, the invention provides a method of predicting whether a subject having colorectal cancer is likely to respond to treatment with a BRAF inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof), the method comprising the step of determining the mutational status of BRAF gene in the colorectal cancer and selecting the subject for treatment if the BRAF gene is a BRAF mutant, wherein the BRAF inhibitor is administered to the subject in combination with an ALK / TRK inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof). In some embodiments, the invention provides a method of predicting whether a subject having colorectal cancer is likely to respond to treatment with an ALK / TRK inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof), the method comprising determining the mutational status of BRAF gene in the colorectal cancer and selecting the subject for treatment if the BRAF gene is a BRAF mutant, wherein the ALK / TRK inhibitor is administered to the subject in combination with a BRAF inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof).

[0015] Data generated by the inventors and described herein suggest that the combination of a BRAF inhibitor and an ALK / TRK inhibitor may provide a synergistic effect against colorectal cancer cells, that is the BRAF inhibitor and the ALK / TRK inhibitor are more potent and promote more cell-death against colorectal cancer cells than the BRAF inhibitor and ALK / TRK inhibitor alone.

[0016] Furthermore, the inventors have identified the combination of a BRAF inhibitor and an ALK / TRK inhibitor as a potent combination in BRAF mutant colorectal cancer cells, the combination sensitising the mutant cells, driving cell apoptosis and enhancing response when compared to BRAF wild-type colorectal cancer cells. In particular, the BRAF mutation in the BRAF mutant colorectal cancer is a cancer driver mutation. Specifically, the BRAF mutation in the BRAF mutant colorectal cancer is a BRAF / W0Emutation.

[0017] Accordingly, in some embodiments the colorectal cancer is BRAF mutant colorectal cancer. In some embodiments, the BRAF mutation in the BRAF mutant colorectal cancer is a cancer driver mutation. In some embodiments, the BRAF mutation in the BRAF mutant colorectal cancer is a BRAF / W0mutation. In some embodiments, the BRAF mutation in the BRAF mutant colorectal cancer is selected from the group consisting of a BRAFJ600Emutation, a BRAPJ600Kmutation, a BRAF6000mutation, a BRAF7600Rmutation, or a BRAFV600Mmutation. In some embodiments, the BRAF mutation in the BRAF mutant colorectal cancer is a BRAF'7600Emutation. In some embodiments, the BRAF mutation in the BRAF mutant colorectal cancer results in increased activity of BRAF protein. For example, in some embodiments, the BRAF mutation in the BRAF mutant colorectal cancer results in increased kinase activity of BRAF, constitutive activation of BRAF, and / or insensitivity to negative feedback. In some embodiments, the method of treatment comprises a step of determining the patient’s BRAF mutational status.

[0018] Suitably, the BRAF inhibitor may be selected from the group consisting of vemurafenib, dabrafenib, regorafenib, sorafenib, encorafenib, CFT-1946, tinlorafenib, ARQ-736, RAF-265, BAL-3833, and XL-281. In some embodiments, the BRAF inhibitor is selected from the group consisting of vemurafenib, dabrafenib, regorafenib, encorafenib, tinlorafenib, and XL-281. In some embodiments, the BRAF inhibitor is selected from the group consisting of vemurafenib and dabrafenib.

[0019] Suitably, the ALK / TRK inhibitor may be selected from the group consisting of ASP-3026, belizatinib, CEP- 37440, TPX-0131 , alectinib, ceritinib, crizotinib, entrectinib, foretinib, merestinib, GW441756, unecritinib, CT-3505, conteltinib, and envonalkib. In some embodiments, the ALK / TRK inhibitor is selected from the group consisting of belizatinib, crizotinib, entrectinib, TPX-0131 , envonalkib, unecritinib, and CT-3505. In some embodiments, the ALK / TRK inhibitor is selected from the group consisting of belizatinib, crizotinib, entrectinib, TPX-0131 , envonalkib, and unecritinib. In some embodiments, the ALK / TRK inhibitor is belizatinib.

[0020] Accordingly, the combination of a BRAF inhibitor and an ALK / TRK inhibitor may be selected from: vemurafenib and belizatinib; vemurafenib and alectinib; vemurafenib and ceritinib; vemurafenib and crizotinib; vemurafenib and entrectinib; vemurafenib and ASP-3026; vemurafenib and CEP-37440; vemurafenib and TPX-0131 ; vemurafenib and conteltinib; vemurafenib and envonalkib; vemurafenib and merestinib; vemurafenib and foretinib; vemurafenib and GW441756; dabrafenib and belizatinib; sorafenib and belizatinib; RAF-265 and belizatinib; CFT-1946 and entrectinib; vemurafenib and unecritinib; and BAL-3833 and entrectinib. In some embodiments, the combination of a BRAF inhibitor and an ALK / TRK inhibitor is selected from: vemurafenib and belizatinib; vemurafenib and entrectinib; vemurafenib and crizotinib; vemurafenib and envonalkib; vemurafenib and TPX-0131 ; vemurafenib and unecritinib; and dabrafenib and belizatinib. In some embodiments, the combination of a BRAF inhibitor and an ALK / TRK inhibitor is selected from: vemurafenib and belizatinib or vemurafenib and entrectinib. In some embodiments, the combination of a BRAF inhibitor and an ALK / TRK inhibitor is vemurafenib and entrectinib.

[0021] It will be understood that the BRAF inhibitor and the ALK / TRK inhibitor may be administered together or separately and may be administered at the same time or at different times. For example, the compounds may be administered on different days as part of a treatment cycle or treatment regimen. Suitably but not necessarily the BRAF inhibitor and the ALK / TRK inhibitor will be formulated separately. For example, each or either compound may be formulated for oral, parenteral, or intravenous administration.

[0022] The combination therapies claimed may be used both curatively and palliatively. They may lead to better patient outcomes and / or quality of life when compared to other treatment regimens and additionally or alternatively may expand the treatment options available to patients.

[0023] The invention includes the combination of the aspects and preferred features described except where such a combination is clearly impermissible or expressly avoided. Summary of the Figures

[0024] Embodiments and experiments illustrating the principles of the invention will now be discussed with reference to the accompanying figures in which:

[0025] Figure 1 : Correlation of BRAF""1* biomarker with synergy in response to Vemurafenib + Belizatinib in colorectal cancer cell lines. Drug-drug screen Iog2 AIC50 (A) and AEmax (B) are plotted against mutation status for BRAF. Each point is the mean response of a single cell line. Box and whisker plots show the median and interquartile range. WT: wild-type; MUT: Cancer driver mutant. See Example 1.

[0026] Figure 2: Correlation of BRAF""1* biomarker with sensitivity to Vemurafenib + Belizatinib in colorectal cancer cell lines. Drug-drug screen Iog2 AI C50 (A), AEmax (B), and Bliss Window (C) are plotted against mutation status for BRAF. Each point is one replicate and represents one cell line. Plots show the median and interquartile range. WT: wild-type; MUT: Cancer driver mutant. See Example 2.

[0027] Figure 3: Correlation of BRAF""1* biomarker with sensitivity to Vemurafenib + Entrectinib in colorectal cancer cell lines. Drug-drug screen Iog2 AI C50 (A), AEmax (B), and Bliss Window (C) are plotted against mutation status for BRAF. Each point is one replicate and represents one cell line. Plots show the median and interquartile range. WT: wild-type; MUT: Cancer driver mutant. See Example 2.

[0028] Figure 4: Correlation of BRAF""1* biomarker with sensitivity to Vemurafenib + Crizotinib in colorectal cancer cell lines. Drug-drug screen Iog2 AI C50 (A), AEmax (B), and Bliss Window (C) are plotted against mutation status for BRAF. Each point is one replicate and represents one cell line. Plots show the median and interquartile range. WT: wild-type; MUT: Cancer driver mutant. See Example 2.

[0029] Figure 5: Correlation of BRAF""1* biomarker with sensitivity to Vemurafenib + Envonalkib in colorectal cancer cell lines. Drug-drug screen Iog2 AI C50 (A), AEmax (B), and Bliss Window (C) are plotted against mutation status for BRAF. Each point is one replicate and represents one cell line. Plots show the median and interquartile range. WT: wild-type; MUT: Cancer driver mutant. See Example 2.

[0030] Figure 6: Correlation of BRAF""1* biomarker with sensitivity to Vemurafenib + TPX-0131 in colorectal cancer cell lines. Drug-drug screen Iog2 AI C50 (A), AEmax (B), and Bliss Window (C) are plotted against mutation status for BRAF. Each point is one replicate and represents one cell line. Plots show the median and interquartile range. WT: wild-type; MUT: Cancer driver mutant. See Example 2.

[0031] Figure 7: Correlation of BRAF""1* biomarker with sensitivity to Vemurafenib + Unecritinib in colorectal cancer cell lines. Drug-drug screen Iog2 AI C50 (A), AEmax (B), and Bliss Window (C) are plotted against mutation status for BRAF. Each point is one replicate and represents one cell line. Plots show the median and interquartile range. WT: wild-type; MUT: Cancer driver mutant. See Example 2.

[0032] Figure 8: Correlation of BRAF""1* biomarker with sensitivity to Dabrafenib + Belizatinib in colorectal cancer cell lines. Drug-drug screen Iog2 AI C50 (A), AEmax (B), and Bliss Window (C) are plotted against mutation status for BRAF. Each point is one replicate and represents one cell line. Plots show the median and interquartile range. WT: wild-type; MUT: Cancer driver mutant. See Example 2. Detailed Description of the Invention

[0033] Aspects and embodiments of the present invention will now be discussed with reference to the accompanying figures. Further aspects and embodiments will be apparent to those skilled in the art. All documents mentioned in this text are incorporated herein by reference.

[0034] It should be noted that “compounds”, “inhibitors”, and “active ingredients” are used interchangeably throughout. References to “compounds”, “inhibitors”, and “active ingredients” also include antibodies.

[0035] BRAF inhibitor

[0036] The BRAF gene, also known as proto-oncogene B-Raf or v-Raf murine sarcoma viral oncogene homolog, is a gene that encodes a protein called BRAF (or B-Raf).

[0037] The BRAF protein is a 766-amino acid, regulated signal transduction serine / threonine-specific protein kinase. It is composed of three conserved domains characteristic of the Raf kinase family: (i) conserved region 1 (CR1), a Ras-GTP-binding self-regulatory domain; (ii) conserved region 2 (CR2), a serine-rich hinge region; and (iii) conserved region 3 (CR3), a catalytic protein kinase domain that phosphorylates a consensus sequence on protein substrates. In its active conformation, the BRAF protein forms dimers via hydrogen-bonding and electrostatic interactions of its kinase domains. It catalyses the phosphorylation of serine and threonine residues in a consensus sequence on target proteins by ATP, yielding ADP and a phosphorylated protein as products. The BRAF protein is a highly regulated signal transduction kinase and must first bind Ras-GTP before becoming active as an enzyme. Once BRAF is activated, a conserved protein kinase catalytic core phosphorylates protein substrates by promoting the nucleophilic attack of the activated substrate serine or threonine hydroxyl oxygen atom on the y-phosphate group of ATP through bimolecular nucleophilic substitution.

[0038] The BRAF protein is involved in sending signals inside cells involved in directing cell growth. Mutations in BRAF gene can cause birth defects and some cancers by excessively signalling cells to grow.

[0039] Inhibitors of BRAF inhibit the BRAF protein in both the inactive and active conformations of the kinase domain, preventing the excessive growth signals. These BRAF inhibitors are thought to be useful in the treatment of cancer, such as colorectal cancer.

[0040] Examples of BRAF inhibitors for use in the combinations described herein are vemurafenib, dabrafenib, regorafenib, sorafenib, encorafenib, tovorafenib, avutometinib potassium, belvarafenib, BGB-3245, CFT- 1946, lifirafenib maleate, LUT-014, naporafenibum, plixorafenib, RX-208, ABM-1310, APL-102, BDTX- 4933, exarafenib, JZP-815, PF-07799933, RG-6344, RXDX-105, tinlorafenib, UB-941 , XP-102, DCC- 3084, ELI-007, INU-152, PV-103, SJP-1601 , SJP-601 , VRN-14, P-4B, AFX-1251 , AR-00457679, ARI- 4175, ARQ-736, CCT-196969, CCT-241161 , CT-207, CT-317, DP-2514, DP-3346, EBI-907, EBI-945, GDC-0879, LYN-204, NMSP-285, NMSP-383, NMSP-730, PLX-4720, RAF-265, REDX-04988, TAK-632, TEW-0201 , TQB-3233, BAL-3833, LY-3009120, PLX-3603, and XL-281. Preferably, the BRAF inhibitors for use in the combinations described herein are selected from the group consisting of vemurafenib, dabrafenib, regorafenib, sorafenib, encorafenib, CFT-1946, tinlorafenib, ARQ- 736, RAF-265, BAL-3833, and XL-281 .

[0041] In some embodiments, the BRAF inhibitors for use in the combinations described herein are selected from the group consisting of vemurafenib, dabrafenib, regorafenib, encorafenib, tinlorafenib, and XL-281 .

[0042] Preferably, the BRAF inhibitors for use in the combinations described herein are selected from the group consisting of vemurafenib and dabrafenib.

[0043] Vemurafenib

[0044] Vemurafenib is also referred to as PLX4032, RG7204, and RO5185426. is a first-in-class, selective, potent inhibitor of BRAF kinase, with IC50 values of 31 and 48 nM for RAFV600Eand c-RAF-1 , respectively.

[0045] Vemurafenib induces cell autophagy. Its structure is:

[0046] In IUPAC nomenclature, it may be referred to as A / -[3-[5-(4-chlorophenyl)-1 / 7-pyrrolo[2,3-b]pyridine-3- carbonyl]-2,4-difluorophenyl]propane-1 -sulfonamide. Its synthesis is known in the art and the compound is commercially available.

[0047] Dabrafenib

[0048] Dabrafenib, also known as GSK2118436A, is an ATP-competitive inhibitor of Raf with IC50 values of 5 nM and 0.6 nM for C-Raf and B-Raf'7600E, respectively. Its structure is:

[0049] In IUPAC nomenclature, it may be referred to as A / -[3-[5-(2-aminopyrimidin-4-yl)-2-te / Y-butyl-1 ,3-thiazol-4- yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide. Its synthesis is known in the art and the compound is commercially available.

[0050] Regorafenib, also referred to as BAY 73-4506, is an orally active and potent multi-targeted receptor tyrosine kinase inhibitor, with IC50 values of 13 / 4.2 / 46 nM for VEGFR1 / 2 / 3, 22 nM for PDGFRp, 7 nM for Kit, 1 .5 nM for RET, and 2.5 nM for Raf-1 , respectively. Regorafenib shows robust anti-tumour and antiangiogenic activity. Its structure is:

[0051] In IUPAC nomenclature, it may be referred to as 4-[4-[[4-chloro-3-

[0052] (trifluoromethyl)phenyl]carbamoylamino]-3-fluorophenoxy]- / V-methylpyridine-2-carboxamide. Its synthesis is known in the art and the compound is commercially available.

[0053] Sorafenib

[0054] Sorafenib, also known as Bay 43-9006, is a potent and orally active Raf inhibitor with IC50 values of 6 nM and 20 nM for Raf-1 and B-Raf, respectively. It is a multikinase inhibitor with IC50 values of 90 nM for VEGFR2, 15 nM for VEGFR3, 20 nM for PDGFRp, 57 nM for FLT3, and 58 nM for c-Kit, respectively. Sorafenib induces autophagy and apoptosis, and has anti-tumour activity. Sorafenib is also a ferroptosis activator. Its structure is:

[0055] In IUPAC nomenclature, it may be referred to as 4-[4-[[4-chloro-3- (trifluoromethyl)phenyl]carbamoylamino]phenoxy]-A / -methylpyridine-2-carboxamide. Its synthesis is known in the art and the compound is commercially available.

[0056] Encorafenib

[0057] Encorafenib, also known as LGX818, is a highly potent BRAF inhibitor with selective anti-proliferative and apoptotic activity in cells expressing BRAFV600E(with an EC50 of 4 nM). Its structure is:

[0058] In IUPAC nomenclature, it may be referred to as methyl A / -[(2S)-1-[[4-[3-[5-chloro-2-fluoro-3- (methanesulfonamido)phenyl]-1-propan-2-ylpyrazol-4-yl]pyrimidin-2-yl]amino]propan-2-yl]carbamate. Its synthesis is known in the art and the compound is commercially available.

[0059] CFT-1946

[0060] CFT-1946 (or CFT1946) is an orally active, CRBN-based and mutant-selective bifunctional degradation activating compound (BiDAC™) degrader of BRAFV600Ewith a DC50 of 14 nM in A375 cells. CFT1946 is capable of degrading BRAF V600E (Class I), G469A (Class II), G466V (Class III) mutations, and the p61- BRAFV600Esplice variant. Its structure is:

[0061] In IUPAC nomenclature, it may be referred to as (3R)-3-[6-[2-cyano-3-[[ethyl(methyl)sulfamoyl]amino]-6- fluorophenoxy]-4-oxoquinazolin-3-yl]-8-[2-[1-[3-(2,4-dioxo-1 ,3-diazinan-1-yl)-5-fluoro-1-methylindazol-6- yl]-4-hydroxypiperidin-4-yl]acetyl]-1-oxa-8-azaspiro[4.5]decane. Its synthesis is known in the art and the compound is commercially available.

[0062] Tinlorafenib

[0063] Tinlorafenib, also known as PF-07284890, is an orally active BRAF kinase inhibitor, with IC50 values of 4.25 and 2.7 nM for BRAFV600Eand BRAFV600K, respectively. Tinlorafenib demonstrates CNS penetration. Its structure is:

[0064] In IUPAC nomenclature, it may be referred to as A / -[2-chloro-3-[(3,5-dimethyl-4-oxoquinazolin-6- yl)amino]-4-fluorophenyl]-3-fluoropropane-1 -sulfonamide. Its synthesis is known in the art and the compound is commercially available.

[0065] ARQ-736

[0066] ARQ-736 is a potent and selective B-RAF inhibitor. It is thought to be useful in the treatment of cancer. Its structure is:

[0067] P-0

[0068] Nad ONa

[0069] In IUPAC nomenclature, it may be referred to as [3-[5-[2-[[(3R)-1-(1-methylpyrazol-3-yl)sulfonylpiperidin- 3-yl]amino]pyrimidin-4-yl]imidazo[2,1-b][1 ,3]oxazol-6-yl]phenoxy]methyl phosphate disodium. Its synthesis is known in the art and the compound is commercially available. RAF-265

[0070] RAF-265 (or RAF265 or CHIR-265) is a potent and orally active RAF / VEGFR2 inhibitor, and exhibits potent inhibition on VEGFR2 phosphorylation with EC5o of 30 nM in cell-free assays. It is also a potent selective inhibitor of C-Raf / B-Raf / B-Raf V600E with IC50 of 3-60 nM. RAF-265 induces cell cycle arrest and apoptosis. Its structure is:

[0071] In IUPAC nomenclature, it may be referred to as 1-methyl-5-[2-[5-(trifluoromethyl)-1 / 7-imidazol-2- yl]pyridin-4-yl]oxy-A / -[4-(trifluoromethyl)phenyl]benzimidazol-2-amine. Its synthesis is known in the art and the compound is commercially available.

[0072] BAL-3833

[0073] BAL-3833 is also known as BAL3833, CCT3833, and TBAP-001. It is an orally available inhibitor of the serine / threonine protein kinase family Raf, including A-Raf, B-Raf and C-Raf, with potential antineoplastic activity. BAL-3833 has an IC50 of 62 nM in a BRAF V600E kinase assay. Upon administration, pan-RAF kinase inhibitor BAL-3833 inhibits Raf-mediated signal transduction pathways, which may inhibit the proliferation of Raf-overexpressing tumour cells. Raf protein kinases play a key role in the RAF / mitogen- activated protein kinase kinase (MEK) / extracellular signal-regulated kinase (ERK) signaling pathway, which is often dysregulated in human cancers and plays a key role in tumour cell proliferation and survival. Its structure is:

[0074] In IUPAC nomenclature, it may be referred to as 1-[5-fe / Y-butyl-2-(3-fluorophenyl)pyrazol-3-yl]-3-[2-fluoro- 4-[(3-oxo-4 / 7-pyrido[2,3-b]pyrazin-8-yl)oxy]phenyl]urea. Its synthesis is known in the art and it is commercially available.

[0075] XL-281

[0076] XL-281 , also known as BMS 908662, is a potent, selective, orally active inhibitor of wild-type and mutant RAF kinases with anti-tumour activity in multiple xenograft models. This anticancer compound potently inhibits the RAS / RAF / MEK / ERK signalling pathway. Its structure is:

[0077] In IUPAC nomenclature, it may be referred to as methyl A / -[6-[2-(5-chloro-2-methylphenyl)-1-hydroxy-3- oxoisoindol-1-yl]-1 / 7-benzimidazol-2-yl]carbamate. Its synthesis is known in the art and the compound is commercially available.

[0078] ALK / TRK inhibitor

[0079] Anaplastic lymphoma kinase (ALK), also known as ALK tyrosine kinase receptor or CD246 (cluster of differentiation 246), is an enzyme that in humans is encoded by the ALK gene. ALK is a receptor tyrosine kinase (RTK), having an extracellular ligand-binding domain, a transmembrane domain, and an intracellular tyrosine kinase domain. The tyrosine kinase domain of human ALK shares a high degree of similarity with that of the insulin receptor, its extracellular domain is unique among the RTK family in containing two MAM domains (meprin, A5 protein and receptor protein tyrosine phosphatase mu), an LDLa domain (low-density lipoprotein receptor class A) and a glycine-rich region. ALK is closely related to the leukocyte receptor tyrosine kinase (LTK) based on overall homology and, together with the insulin receptor, forms a subgroup in the RTK superfamily. The human ALK gene encodes a protein 1 ,620 amino acids long with a molecular weight of 180 kDa.

[0080] The full-length receptor ALK dimerizes, changes conformation, and autoactivates its own kinase domain. This activation phosphorylates other ALK receptors in trans on specific tyrosine amino acid residues. ALK phosphorylated residues serve as binding sites for the recruitment of several adaptor and other cellular proteins, such as GRB2, IRS1 , She, Src, FRS2, PTPN11 / Shp2, PLCy, PI3K, and NF1. Other reported downstream ALK targets include FOXO3a, CDKN1 B / p27kip, cyclin D2, NIPA, RAC1 , CDC42, p130CAS, SHP1 , and PIKFYVE.

[0081] Phosphorylated ALK activates multiple downstream signal transduction pathways, including MAPK-ERK, PI3K-AKT, PLCy, CRKL-C3G, and JAK-STAT. ALK is also though to regulate retinal axon targeting, growth and size, synapse development at the neuromuscular junction, behavioral responses to ethanol, and sleep.

[0082] The ALK gene is thought to be oncogenic in three ways: (i) by forming a fusion gene with any of several other genes, (ii) by gaining additional gene copies, or (iii) with mutations of the actual DNA code for the gene itself.

[0083] ALK inhibitors are anti-cancer drugs that act on tumours with variations of anaplastic lymphoma kinase (ALK) such as an EML4-ALK translocation. They are tyrosine kinase inhibitors, which work by inhibiting proteins involved in the abnormal growth of tumour cells. At present, the approved ALK inhibitors are thought to function by binding to the ATP pocket of the abnormal ALK protein, blocking its access to energy and deactivating it. Inhibitors of ALK are therefore thought to be useful in the treatment of cancer, such as colorectal cancer.

[0084] TRK (or Trk) receptors are a family of tyrosine kinases that regulates synaptic strength and plasticity in the mammalian nervous system. TRK receptors affect neuronal survival and differentiation through several signalling cascades. However, the activation of these receptors also has significant effects on functional properties of neurons.

[0085] The common ligands of TRK receptors are neurotrophins, a family of growth factors critical to the functioning of the nervous system. The binding of these molecules is highly specific. Each type of neurotrophin has different binding affinity toward its corresponding TRK receptor. The activation of TRK receptors by neurotrophin binding may lead to activation of signal cascades resulting in promoting survival and other functional regulation of cells.

[0086] The three most common types of TRK receptors are TRKA, TRKB, and TRKC. Each of these receptor types has different binding affinity to certain types of neurotrophins. The differences in the signalling initiated by these distinct types of receptors are important for generating diverse biological responses.

[0087] TRK receptors dimerize in response to ligand, as do other tyrosine kinase receptors. These dimers phosphorylate each other and enhance catalytic activity of the kinase. TRK receptors affect neuronal growth and differentiation through the activation of different signalling cascades, as mentioned above. The three known pathways are PLC, Ras / MAPK (mitogen-activated protein kinase) and the PI3K (phosphatidylinositol 3-kinase) pathways. These pathways involve the interception of nuclear and mitochondrial cell-death programs. These signalling cascades eventually led to the activation of a transcription factor, CREB (cAMP response element-binding), which in turn activate the target genes. Some studies have suggested that NGF / TRKA coupling causes preferential activation of the Ras / MAPK pathway, whereas NT3 / TRKC coupling causes preferential activation of the PI3 pathway.

[0088] The TRK family is believed to have a role in human cancers because of the identification of NTRK1 (TRKA), NTRK2 (TRKB) and NTRK3 (TRKC) gene fusions and other oncogenic alterations in a number of tumour types. It is thought that differential expression of TRK receptors closely correlates to prognosis and outcome in a number of cancers, such as neuroblastoma. In particular, TRKA is seen as a good prognosis marker, as it can induce terminal differentiation of cells, while it is thought TRKB may be associated with a poor prognosis, due to its correlation with MYCN amplification. As a result, TRK inhibitors have been explored as a potential treatment avenue in the field of precision medicine, particularly in cancer such as colorectal cancer.

[0089] Examples of ALK / TRK inhibitors for use in the combinations described herein are ASP-3026, belizatinib, CEP-37440, TPX-0131 , alectinib, brigatinib, ceritinib, crizotinib, ensartinib hydrochloride, entrectinib, foretinib, iruplinalkib, lorlatinib, merestinib, APG-2449, GW441756, LZ-001 , PLB-1003, NUV-655, ZG- 0418, SAF-189, unecritinib, SIM-0201 , CT-3505, conteltinib, envonalkib, and EBI-215. Preferably, the ALK / TRK inhibitors for use in the combinations described herein are selected from the group consisting of ASP-3026, belizatinib, CEP-37440, TPX-0131 , alectinib, ceritinib, crizotinib, entrectinib, foretinib, merestinib, GW441756, unecritinib, CT-3505, conteltinib, and envonalkib.

[0090] In some embodiments, the ALK / TRK inhibitors for use in the combinations described herein are selected from the group consisting of belizatinib, crizotinib, entrectinib, TPX-0131 , envonalkib, unecritinib, and CT- 3505.

[0091] In some embodiments, the ALK / TRK inhibitors for use in the combinations described herein are selected from the group consisting of belizatinib, crizotinib, entrectinib, TPX-0131 , envonalkib, and unecritinib.

[0092] In some embodiments, the ALK / TRK inhibitor is belizatinib.

[0093] In some embodiments, the ALK / TRK inhibitor is an ALK inhibitor. In some embodiments, the ALK / TRK inhibitor is a TRK inhibitor. When the ALK / TRK inhibitor is a TRK inhibitor, the TRK inhibitor may be a TRKA inhibitor, TRKB inhibitor, or a TRKC inhibitor. In some embodiments, the TRK inhibitor may be a TRKA inhibitor, such that the TRK inhibitor is selective for TRKA. In some embodiments, the TRK inhibitor may be a TRKB inhibitor, such that the TRK inhibitor is selective for TRKB. In some embodiments, the TRK inhibitor may be a TRKC inhibitor, such that the TRK inhibitor is selective for TRKC.

[0094] ASP-3026

[0095] ASP-3026 (or ASP3026) is a potent, selective, and orally active inhibitor of anaplastic lymphoma kinase (ALK). It has an IC50 of 3.5 nM for ALK. ASP-3026 induces apoptosis of tumour cells. Its structure is:

[0096] In IUPAC nomenclature, it may be referred to as 2-A / -[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1- yl]phenyl]-4-A / -(2-propan-2-ylsulfonylphenyl)-1 ,3,5-triazine-2,4-diamine. Its synthesis is known in the art and the compound is commercially available.

[0097] Belizatinib

[0098] Belizatinib, also known as TSR-011 , is an oral, dual, potent inhibitor of ALK and TRKA, TRKB, and TRKC. It has an IC50 of 0.7 nM for wild-type recombinant ALK kinase. Its structure is:

[0099] In IUPAC nomenclature, it may be referred to as 4-fluoro-A / -[6-[[4-(2-hydroxypropan-2-yl)piperidin-1- yl]methyl]-1-[4-(propan-2-ylcarbamoyl)cyclohexyl]benzimidazol-2-yl]benzamide. Its synthesis is known in the art and the compound is commercially available.

[0100] CEP-37440

[0101] CEP-37440 is a potent, orally active dual FAK / ALK inhibitor with IC50 values of 2.3 nM and 3.5 nM for

[0102] FAK and ALK, respectively. CEP-37440 decreases the cell proliferation by blocking the autophosphorylation kinase activity of FAK1 (Tyr 397). Its structure is:

[0103] In IUPAC nomenclature, it may be referred to as 2-[[5-chloro-2-[[(6S)-6-[4-(2-hydroxyethyl)piperazin-1-yl]- 1-methoxy-6,7,8,9-tetrahydro-5 / 7-benzo[7]annulen-2-yl]amino]pyrimidin-4-yl]amino]-A / -methylbenzamide. Its synthesis is known in the art and the compound is commercially available.

[0104] TPX-0131

[0105] TPX-0131 is also known as zotizalkib. It is a potent, selective, CNS-penetrant, and orally active inhibitor of wild-type ALK (IC50 of 1 .4 nM) and ALK-resistant mutations, for example: G1202R (IC50 of 0.3 nM), and L1196M (IC50 of 0.3 nM). TPX-0131 has strong anti-tumour activities. Its structure is:

[0106] In IUPAC nomenclature, it may be referred to as (18S)-18-(difluoromethyl)-13-fluoro-7,7-dimethyl-9,20- dioxa-1 ,2,6,17,23-pentazapentacyclo[19.3.1.0424.010 15.017 22]pentacosa-2,4(24),10(15),11 ,13,21 (25),22- heptaen-5-one. Its synthesis is known in the art and the compound is commercially available. Alectinib

[0107] Alectinib is also known as CH5424802, RO5424802, and RG7853. It is a potent, selective, and orally available ALK inhibitor with an IC50 of 1 .9 nM and a Kd value of 2.4 nM (in an ATP-competitive manner). It also inhibits ALK F1174L and ALK R1275Q with IC50 values of 1 nM and 3.5 nM, respectively. Alectinib demonstrates effective central nervous system (CNS) penetration. Its structure is:

[0108] In IUPAC nomenclature, it may be referred to as 9-ethyl-6,6-dimethyl-8-(4-morpholin-4-ylpiperidin-1-yl)- 11-oxo-5 / 7-benzo[b]carbazole-3-carbonitrile. Its synthesis is known in the art and the compound is commercially available.

[0109] Ceritinib

[0110] Ceritinib, also known as LDK378, is a selective, orally bioavailable, and ATP-competitive ALK tyrosine kinase inhibitor with an IC50 of 200 pM. It also inhibits IGF-1 R, InsR, and STK22D with IC50 values of 8, 7, and 23 nM, respectively. Ceritinib shows great anti-tumour potency. Its structure is:

[0111] In IUPAC nomenclature, it may be referred to as 5-chloro-2-A / -(5-methyl-4-piperidin-4-yl-2-propan-2- yloxyphenyl)-4-A / -(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine. Its synthesis is known in the art and the compound is commercially available.

[0112] Crizotinib

[0113] Crizotinib, also referred to as PF-02341066, is an orally bioavailable, ATP-competitive ALK and c-Met inhibitor with IC50 values of 20 and 8 nM, respectively. It inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC50 values of 24 and 11 nM in cell-based assays, respectively. It is also a ROS1 inhibitor and has effective tumour growth inhibition. Its structure is:

[0114] In IUPAC nomenclature, it may be referred to as 3-[(1 R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1- piperidin-4-ylpyrazol-4-yl)pyridin-2-amine. Its synthesis is known in the art and the compound is commercially available. Entrectinib

[0115] Entrectinib is also known as NMS-E628 or RXDX-101. It is an orally active, BBB-penetrated and centrally active inhibitor of TrkA / B / C1 (IC50 values of 1 , 3, and 5 nM), ROS1 (IC50 value of 12 nM), and ALK (IC50 value of 7 nM). Entrectinib induces apoptosis and cycle arrest in cancer cells, has anti-tumour activity, and attenuates bleomycin-induced lung fibrosis in mice. Its structure is:

[0116] In IUPAC nomenclature, it may be referred to as A / -[5-[(3,5-difluorophenyl)methyl]-1 / 7-indazol-3-yl]-4-(4- methylpiperazin-1-yl)-2-(oxan-4-ylamino)benzamide. Its synthesis is known in the art and the compound is commercially available.

[0117] Foretinib

[0118] Foretinib is also referred to as XL880, GSK1363089, GSK089, or EXEL-2880. It is an ATP-competitive, multi-target tyrosine kinase inhibitor, such as HGFR and VEGFR with IC50 values of 0.4 nM and 0.9 nM for Met and KDR in cell-free assays, respectively. It is less potent against Ron, Flt-1 / 3 / 4, Kit (c-Kit), PDGFRa / p and Tie-2, and little activity to FGFR1 and EGFR. Its structure is:

[0119] In IUPAC nomenclature, it may be referred to as 1-A / '-[3-fluoro-4-[6-methoxy-7-(3-morpholin-4- ylpropoxy)quinolin-4-yl]oxyphenyl]-1-A / -(4-fluorophenyl)cyclopropane-1 ,1-dicarboxamide. Its synthesis is known in the art and the compound is commercially available.

[0120] Merestinib

[0121] Merestinib, also known as LY2801653, is a potent, orally bioavailable c-Met inhibitor (Ki of 2 nM) with anti-tumour activities. It also has potent activity against MST1 R (IC50 of 1 1 nM), FLT3 (IC50 of 7 nM), AXL (IC50 of 2 nM), MERTK (IC50 of 10 nM), TEK (IC50 of 63 nM), ROS1 , DDR1 / 2 (IC50 of 0.1 / 7 nM, repectively) and MKNK1 / 2 (IC50 of 7 nM). Its structure is:

[0122] In IUPAC nomenclature, it may be referred to as A / -[3-fluoro-4-[1-methyl-6-(1 / 7-pyrazol-4-yl)indazol-5- yl]oxyphenyl]-1-(4-fluorophenyl)-6-methyl-2-oxopyridine-3-carboxamide. Its synthesis is known in the art and the compound is commercially available.

[0123] GW441756

[0124] GW441756 (or GW 441756) is a potent and specific nerve growth factor (NGF) receptor tyrosine kinases A (TrkA) inhibitor (IC50 of 2 nM), which eliminates the BmK NSPK-induced neurite outgrowth. It has very little activity to c-Raf1 and CDK2. GW441756 produces a relevant increase of caspase-3 that leads to apoptosis. Its structure is:

[0125] In IUPAC nomenclature, it may be referred to as (3Z)-3-[(1-methylindol-3-yl)methylidene]-1 / 7-pyrrolo[3,2- b]pyridin-2-one. Its synthesis is known in the art and the compound is commercially available.

[0126] Unecritinib

[0127] Unecritinib, also referred to as TQ-B3101 , is a potent EGFR tyrosine kinase inhibitor. Unecritinib shows anticancer activity. Unecritinib inhibits ALK, ROS1 , and MET. Unecritinib has the potential for the research of solid tumour and relapsed or refractory ALK-positive anaplastic large cell lymphoma. Its structure is:

[0128] In IUPAC nomenclature, it may be referred to as A / -[3-[(1 R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1- piperidin-4-ylpyrazol-4-yl)pyridin-2-yl]acetamide. Its synthesis is known in the art and the compound is commercially available. CT-3505

[0129] CT-3505, also known as SY-3505 and ficonalkib, is an ALK inhibitor. Its structure is:

[0130] In IUPAC nomenclature, it may be referred to as 2-A / -[4-[4-(dimethylamino)piperidin-1-yl]-2- methoxyphenyl]-4-A / -(2-propan-2-ylsulfonylphenyl)-6,7-dihydro-5 / 7-pyrrolo[2,3-d]pyrimidine-2,4-diamine.

[0131] Its synthesis is known in the art and the compound is commercially available.

[0132] Conteltinib

[0133] Conteltinib, also known as CT-707, is a multi-kinase inhibitor targeting FAK, ALK, and Pyk2. Conteltinib exerts significant inhibitory effect on FAK with an IC50 of 1 .6 nM. Its structure is:

[0134] In IUPAC nomenclature, it may be referred to as 2-[[2-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin- 1-yl]anilino]-6,7-dihydro-5 / 7-pyrrolo[2,3-d]pyrimidin-4-yl]amino]-A / -propan-2-ylbenzenesulfonamide. Its synthesis is known in the art and the compound is commercially available.

[0135] Envonalkib

[0136] Envonalkib is also referred to as TQ-B3139 or CT-71. It is a potent and orally active inhibitor of ALK, with IC50 values of 1 .96 nM, 35.1 nM, and 61 .3 nM for wild-type and mutated L1196M and G1269S-ALK, respectively. Its structure is:

[0137] In IUPAC nomenclature, it may be referred to as 3-[(1 R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[4- methoxy-6-[(2S)-2-methylpiperazin-1-yl]pyridin-3-yl]pyridin-2-amine. Its synthesis is known in the art and the compound is commercially available. ific inhibitor combinations

[0138] In some cases, the combination of a BRAF inhibitor together with an ALK / TRK inhibitor for use in a method of treatment described herein may be specific inhibitor combinations.

[0139] In some cases, the combination of a BRAF inhibitor together with an ALK / TRK inhibitor for use in a method of treatment described herein may be wherein the BRAF inhibitor is selected from vemurafenib, dabrafenib, regorafenib, sorafenib, encorafenib, CFT-1946, tinlorafenib, ARQ-736, RAF-265, BAL-3833, and XL-281 ; and wherein the ALK / TRK inhibitor is selected from ASP-3026, belizatinib, CEP-37440, TPX- 0131 , alectinib, ceritinib, crizotinib, entrectinib, foretinib, merestinib, GW441756, unecritinib, CT-3505, conteltinib, and envonalkib.

[0140] In some cases, the combination of a BRAF inhibitor together with an ALK / TRK inhibitor for use in a method of treatment described herein may be wherein the BRAF inhibitor is selected from vemurafenib, dabrafenib, regorafenib, encorafenib, tinlorafenib, and XL-281 ; and wherein the ALK / TRK inhibitor is selected from belizatinib, crizotinib, entrectinib, TPX-0131 , envonalkib, unecritinib, and CT-3505.

[0141] In some cases, the combination may be selected from: vemurafenib and ASP-3026; vemurafenib and belizatinib; vemurafenib and CEP-37440; vemurafenib and TPX-0131 ; vemurafenib and alectinib; vemurafenib and ceritinib; vemurafenib and crizotinib; vemurafenib and entrectinib; vemurafenib and foretinib; vemurafenib and merestinib; vemurafenib and GW441756; vemurafenib and unecritinib; vemurafenib and CT-3505; vemurafenib and conteltinib; vemurafenib and envonalkib; dabrafenib and ASP-3026; dabrafenib and belizatinib; dabrafenib and CEP-37440; dabrafenib and TPX- 0131 ; dabrafenib and alectinib; dabrafenib and ceritinib; dabrafenib and crizotinib; dabrafenib and entrectinib; dabrafenib and foretinib; dabrafenib and merestinib; dabrafenib and GW441756; dabrafenib and unecritinib; dabrafenib and CT-3505; dabrafenib and conteltinib; dabrafenib and envonalkib; regorafenib and ASP-3026; regorafenib and belizatinib; regorafenib and CEP-37440; regorafenib and TPX-0131 ; regorafenib and alectinib; regorafenib and ceritinib; regorafenib and crizotinib; regorafenib and entrectinib; regorafenib and foretinib; regorafenib and merestinib; regorafenib and GW441756; regorafenib and unecritinib; regorafenib and CT-3505; regorafenib and conteltinib; regorafenib and envonalkib; sorafenib and ASP-3026; sorafenib and belizatinib; sorafenib and CEP-37440; sorafenib and TPX-0131 ; sorafenib and alectinib; sorafenib and ceritinib; sorafenib and crizotinib; sorafenib and entrectinib; sorafenib and foretinib; sorafenib and merestinib; sorafenib and GW441756; sorafenib and unecritinib; sorafenib and CT-3505; sorafenib and conteltinib; sorafenib and envonalkib; encorafenib and ASP-3026; encorafenib and belizatinib; encorafenib and CEP-37440; encorafenib and TPX-0131 ; encorafenib and alectinib; encorafenib and ceritinib; encorafenib and crizotinib; encorafenib and entrectinib; encorafenib and foretinib; encorafenib and merestinib; encorafenib and GW441756; encorafenib and unecritinib; encorafenib and CT-3505; encorafenib and conteltinib; encorafenib and envonalkib;

[0142] CFT-1946 and ASP-3026; CFT-1946 and belizatinib; CFT-1946 and CEP-37440; CFT-1946 and TPX- 0131 ; CFT-1946 and alectinib; CFT-1946 and ceritinib; CFT-1946 and crizotinib; CFT-1946 and entrectinib; CFT-1946 and foretinib; CFT-1946 and merestinib; CFT-1946 and GW441756; CFT-1946 and unecritinib, CT-3505; CFT-1946 and conteltinib; CFT-1946 and envonalkib; tinlorafenib and ASP-3026; tinlorafenib and belizatinib; tinlorafenib and CEP-37440; tinlorafenib and TPX- 0131 ; tinlorafenib and alectinib; tinlorafenib and ceritinib; tinlorafenib and crizotinib; tinlorafenib and entrectinib; tinlorafenib and foretinib; tinlorafenib and merestinib; tinlorafenib and GW441756; tinlorafenib and unecritinib; tinlorafenib and CT-3505; tinlorafenib and conteltinib; tinlorafenib and envonalkib;

[0143] ARQ-736 and ASP-3026; ARQ-736 and belizatinib; ARQ-736 and CEP-37440; ARQ-736 and TPX-0131 ; ARQ-736 and alectinib; ARQ-736 and ceritinib; ARQ-736 and crizotinib; ARQ-736 and entrectinib; ARQ- 736 and foretinib; ARQ-736 and merestinib; ARQ-736 and GW441756; ARQ-736 and unecritinib; ARQ- 736 and CT-3505; ARQ-736 and conteltinib; ARQ-736 and envonalkib;

[0144] RAF-265 and ASP-3026; RAF-265 and belizatinib; RAF-265 and CEP-37440; RAF-265 and TPX-0131 ; RAF-265 and alectinib; RAF-265 and ceritinib; RAF-265 and crizotinib; RAF-265 and entrectinib; RAF- 265 and foretinib; RAF-265 and merestinib; RAF-265 and GW441756; RAF-265 and unecritinib; RAF-265 and CT-3505; RAF-265 and conteltinib; RAF-265 and envonalkib;

[0145] BAL-3833 and ASP-3026; BAL-3833 and belizatinib; BAL-3833 and CEP-37440; BAL-3833 and TPX- 0131 ; BAL-3833 and alectinib; BAL-3833 and ceritinib; BAL-3833 and crizotinib; BAL-3833 and entrectinib; BAL-3833 and foretinib; BAL-3833 and merestinib; BAL-3833 and GW441756; BAL-3833 and unecritinib; BAL-3833 and CT-3505; BAL-3833 and conteltinib; BAL-3833 and envonalkib;

[0146] XL-281 and ASP-3026; XL-281 and belizatinib; XL-281 and CEP-37440; XL-281 and TPX-0131 ; XL-281 and alectinib; XL-281 and ceritinib; XL-281 and crizotinib; XL-281 and entrectinib; XL-281 and foretinib; XL-281 and merestinib; XL-281 and GW441756; XL-281 and unecritinib; XL-281 and CT-3505; XL-281 and conteltinib, and XL-281 and envonalkib.

[0147] Preferably, the combination may be selected from: vemurafenib and belizatinib; vemurafenib and alectinib; vemurafenib and ceritinib; vemurafenib and crizotinib; vemurafenib and entrectinib; vemurafenib and ASP-3026; vemurafenib and CEP-37440; vemurafenib and TPX-0131 ; vemurafenib and conteltinib; vemurafenib and envonalkib; vemurafenib and merestinib; vemurafenib and foretinib; vemurafenib and GW441756; dabrafenib and belizatinib; sorafenib and belizatinib; RAF-265 and belizatinib; CFT-1946 and entrectinib; vemurafenib and unecritinib; and BAL-3833 and entrectinib.

[0148] Even more preferably, the combination may be selected from: vemurafenib and belizatinib; vemurafenib and entrectinib; vemurafenib and crizotinib; vemurafenib and envonalkib; vemurafenib and TPX-0131 ; vemurafenib and unecritinib; and dabrafenib and belizatinib. In some embodiments, the combination of a BRAF inhibitor and an ALK / TRK inhibitor is selected from: vemurafenib and belizatinib or vemurafenib and entrectinib. In some embodiments, the combination of a BRAF inhibitor and an ALK / TRK inhibitor is vemurafenib and entrectinib.

[0149] As described herein, any compound (for example, a BRAF inhibitor or an ALK / TRK inhibitor) may be provided as a pharmaceutically acceptable salt, hydrate, or solvate. Suitable pharmaceutically acceptable salts are known in the art and are described in, for example, in Berge et al., J Pharm Sci, 1977, 66(1), p1. Accordingly, any BRAF inhibitor or ALK / TRK inhibitor described herein may be provided as a pharmaceutically acceptable salt, such as a dimaleate salt, a mesylate salt, a hydrochloride salt, a ditosylate salt, or a tosylate salt. The pharmaceutically acceptable salts may also be a hydrate or solvate thereof. Any reference to a BRAF inhibitor or an ALK / TRK inhibitor encompasses their pharmaceutically acceptable salts, hydrates, or solvates thereof.

[0150] Administration of active ingredients

[0151] Compounds used in the methods of the invention may be administered by any suitable route, including oral and intravenous routes. It will be understood that oral administration may be preferred. The compounds may be provided in pharmaceutical compositions comprising the compound and one or more pharmaceutically acceptable excipients. Formulation for oral administration may be in the form of a tablet or a capsule comprising a powder or liquid. Typically, small molecules (that is, compounds with a low molecular weight (<1000 daltons) - for example, vemurafenib or entrectinib) may be administered orally.

[0152] Administration is preferably in a “therapeutically effective amount” or an “effective amount” (used interchangeably), this being sufficient to show benefit to the individual. The actual amount administered, and rate and time-course of administration, will depend on the nature and severity of the disease being treated. Prescription of treatment, e.g. decisions on dosage etc, is within the responsibility of general practitioners and other medical doctors, and typically takes account of the disorder to be treated, the condition of the individual patient, the site of delivery, the method of administration and other factors known to practitioners. Examples of the techniques and protocols mentioned above can be found in Remington’s Pharmaceutical Sciences, 20thEdition, 2000, pub. Lippincott, Williams & Wilkins.

[0153] Dosage regimens known in the art for the active ingredients described herein may also be used in the present invention.

[0154] For example, the FDA’s prescribing information for vemurafenib describes the approved dosage form as a 240 mg tablet for oral administration. The recommended dose is 960 mg (4 x 240 mg tablets) every 12 hours, with or without food. Reduced dosing schedules are also indicated in specific circumstances, including 720 mg twice daily, or 480 mg twice daily. Similarly, the FDA’s prescribing information for entrectinib describes approved dosage forms of both 100 mg and 200 mg capsules, in addition to 50 mg pellets. Capsules may be administered orally either swallowed whole or made into an oral suspension for enteral tube administration. Pellets are administrated orally, swallowed with soft food. Recommended doses range from 250 mg / m2(of body surface area) to 600 mg once daily, with increments including 100 mg, 150 mg, 200 mg, 300 mg, and 400 mg once daily, depending on indication, patient age, and incidence of adverse reactions.

[0155] Accordingly, the active ingredients described herein may be administered in dosages of about 1 mg to about 1000 mg, such as about 50 mg to about 800 mg, such as about 100 mg to about 600 mg.

[0156] In some embodiments, the BRAF inhibitor may be administered in a dosage of about 1 mg to about 1000 mg, such as about 240 mg to about 960 mg, such as about 480 mg to about 720 mg.

[0157] In some embodiments, the ALK / TRK inhibitor may be administered in a dosage of about 1 mg to about 1000 mg, such as about 100 mg to about 600 mg.

[0158] In some embodiments, the active ingredients described herein may be administered orally, parenterally, or intravenously. In some embodiments, the active ingredients described herein may be administered orally or parenterally. In some embodiments, the active ingredients described herein may be administered orally. In some embodiments, the active ingredients described herein may be administered parenterally.

[0159] In some embodiments, the active ingredients described herein may be administered intravenously. Each active ingredient may be administered via a different route of administration to the other active ingredient.

[0160] When referring to “a combination” of active ingredients or when the active ingredients are administered “in combination”, the active ingredients described herein may be administered simultaneously, separately or sequentially / consecutively, or at different times within a prescribed dosing cycle. The active ingredients described herein may be administered daily, such as once daily (QD), twice daily (BID), three times daily (TID), or four times daily (QID), or on a less frequent or intermittent schedule.

[0161] Suitably, the patient or subject may be a human patient or subject. “Patient” and “subject” are used interchangeably throughout.

[0162] Colorectal Cancer

[0163] Colon cancer, also known as colorectal cancer or bowel cancer, is a disease in which cells in the colon or rectum grow out of control.

[0164] The bowel is part of the digestive system or gastrointestinal (Gl) system. It is split into 2 parts: the small bowel and the large bowel. The large bowel includes the colon, the rectum and the bowel opening (anus). The colon is the large intestine or large bowel. The rectum is the passageway that connects the colon to the anus.

[0165] Sometimes abnormal growths, called polyps, form in the colon or rectum. Over time, some polyps may turn into cancer. Colorectal cancer affects the large bowel, including the colon and rectum. The treatment of colorectal cancer can sometimes depend on where the cancer starts in your bowel. The invention relates to methods for the treatment of cancer in patients, and in particular the treatment of colon (colorectal) cancer. Preferably, the cancer is colorectal cancer.

[0166] Accordingly, the invention relates to a combination of a BRAF inhibitor and an ALK / TRK inhibitor for use in a method of treatment of colorectal cancer in a patient. The invention also relates to use of a BRAF inhibitor for use in a method of treatment of colorectal cancer in a patient, wherein the BRAF inhibitor is administered to a patient in combination with an ALK / TRK inhibitor. The invention also relates to use of an ALK / TRK inhibitor for use in a method of treatment of colorectal cancer in a patient, wherein the ALK / TRK inhibitor is administered to a patient in combination with a BRAF inhibitor.

[0167] Accordingly, the invention also relates to a method of treatment of colorectal cancer, wherein the method comprises the step of administering a therapeutically effective amount of a combination of a BRAF inhibitor and an ALK / TRK inhibitor to a patient in need thereof. The invention also relates to a method of treatment of colorectal cancer, wherein the method comprises the step of administering a therapeutically effective amount of a BRAF inhibitor to a patient in need thereof, wherein the BRAF inhibitor is administered to the patient in combination with an ALK / TRK inhibitor. The invention also relates to a method of treatment of colorectal cancer, wherein the method comprises the step of administering a therapeutically effective amount of an ALK / TRK inhibitor to a patient in need thereof, wherein the ALK / TRK inhibitor is administered to the patient in combination with a BRAF inhibitor.

[0168] Accordingly, the invention also relates to the use of a combination of a BRAF inhibitor and an ALK / TRK inhibitor for the manufacture of a medicament for the treatment of colorectal cancer in a patient. The invention also relates to the use of a BRAF inhibitor for the manufacture of a medicament for the treatment of colorectal cancer in a patient, wherein the BRAF inhibitor is administered to a patient in combination with an ALK / TRK inhibitor. The invention also relates to the use of an ALK / TRK inhibitor for the manufacture of a medicament for the treatment of colorectal cancer in a patient, wherein the ALK / TRK inhibitor is administered to a patient in combination with a BRAF inhibitor.

[0169] In some embodiments, the colorectal cancer may be a BRAF mutant colorectal cancer.

[0170] BRAF biomarker

[0171] As mentioned above, the BRAF gene, also known as proto-oncogene B-Raf or v-Raf murine sarcoma viral oncogene homolog, is a gene that encodes a protein called BRAF (or B-Raf).

[0172] Mutations in the BRAF gene can cause disease in two ways. First, mutations can be inherited and cause birth defects. Second, mutations can appear later in life and cause cancer, as an oncogene.

[0173] Inherited mutations in this gene cause cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance.

[0174] Mutations in the BRAF gene have been found in cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, papillary thyroid carcinoma, non-small-cell lung carcinoma, adenocarcinoma of the lung, brain tumours including glioblastoma and pleomorphic xanthoastrocytoma as well as inflammatory diseases like Erdheim-Chester disease.

[0175] More than 30 mutations of the BRAF gene associated with human cancers have been identified. The frequency of BRAF mutations varies widely in human cancers, from more than 80% in melanomas and nevi, to as little as 0-18% in other tumours, such as 1-3% in lung cancers and 5% in colorectal cancer.

[0176] In 90% of the cases, thymine is substituted with adenine at nucleotide 1799. This leads to valine (V) being substituted for by glutamate (E) at codon 600 (now referred to as V600E mutation) in the activation segment that has been found in human cancers, resulting in constitutive activation of BRAF. This mutation has been widely observed in papillary thyroid carcinoma, colorectal cancer, melanoma and non- small-cell lung cancer. BRAF-V600E mutation (often written as BRAF'W0E) are present in 57% of Langerhans cell histiocytosis patients. The V600E mutation is a likely driver mutation in 100% of cases of hairy cell leukaemia. High frequency of BRAF V600E mutations have been detected in ameloblastoma, a benign but locally infiltrative odontogenic neoplasm. The V600E mutation may also be linked, as a singledriver mutation (a genetic 'smoking gun') to certain cases of papillary craniopharyngioma development. The V600E mutation of the BRAF gene has also been suggested for use in screening for Lynch syndrome to reduce the number of patients undergoing unnecessary MLH1 sequencing.

[0177] Other mutations which have been found are R461 I, I462S, G463E, G463V, G465A, G465E, G465V, G468A, G468E, G469R, N580S, E585K, D593V, F594L, G595R, L596V, T598I, V599D, V599E, V599K, V599R, V600K, A727V, amongst others, and most of these mutations are clustered to two regions: the glycine-rich P loop of the N lobe and the activation segment and flanking regions. These mutations change the activation segment from inactive state to active state, for example it has been reported that the aliphatic side chain of Val599 interacts with the phenyl ring of Phe467 in the P loop. Replacing the medium-sized hydrophobic Vai side chain with a larger and charged residue as found in human cancer (Glu, Asp, Lys, or Arg) would be expected to destabilize the interactions that maintain the DFG motif in an inactive conformation, so flipping the activation segment into the active position. Depending on the type of mutation the kinase activity towards MEK may also vary. Most of the mutants stimulate enhanced BRAF kinase activity toward MEK. However, a few mutants act through a different mechanism because although their activity toward MEK is reduced, they adopt a conformation that activates wild-type CRAF, which then signals to ERK.

[0178] The BRAF gene is the gene identified by Gene ID: 673 (https: / / www.ncbi.nlm.nih.gov / gene / 673) in the GenBank. The nucleic acid sequence (5 -3') of the wild-type BRAF gene is SEQ ID NO: 1 : GCGCCGCGGCCTCTTCGGCTGCGGACCCTGCCATTCCGGAGGAGGTGAGTGCTGGCGCCACCCTG CCGCCCTCCCGACTCCGGGCTCGGCGGCTGGCTGGTGTTTATTTTGGAAAGAGGCGGCGGTGGGG GCTTGATGCCCTCAGCCACCTTCTCGGGCCAGCTCCGCGGGCTGGGAGGTGGGCATCGCCCCCGT GTCCCTCTCCGTCATGCAGCGCCTTCCTACGTAAACACACACAATGGCCCGGGGGGTTTCCCTGGC

[0179] CCCCACCCCAGATGTGGGGATTGGGGCAGCGGTGGTTGAGCGGGAGGCTATCAATAGGGGGCGAA ACTCAGGGTTGGTCCGAGAAGGTCACGATTGGCTGAAGTATCCAGCTCTGCATCTCTGTGGGGTGG

[0180] GGGCGGCGGCGGCCTCGACGTGGAGGATATAGGTTAGTTGCTGGGGCTGAGACAACAGCCCGAGT TACTGTCGCGTGTAATTCTTACATGGTCGTGGGGATGATGGGGCTCATCATTTCCTCTCTCCTCTCC

[0181] CGGACTGCCCCCCTTCTCAGTCCGCTGCCCTTTTTCACTTTTCTATTTGGGGATTTCTCTTCACCTGT TTTACCCAGCAAATTATTTTGATTTAGTCTTTACTTTTTCAATCCTAAATCGCAGTTTCCGATGCCTTTT CTGGTCTCTGGTCCTCTGTTCCTAATGTTTGTCAGCGCTCTGTCGCTGATTGGTAACCCCCATTCTAT TCCCATCTACCGCCCGCTCATTTTCCAGTTGTCGGACCTGCCTGCCTTCTAACCCCAGCTCCCACTT AAGAGCATTTTTGCACTTCTCTTACCCTGGTCCTCTTGAGGCTCTGTACTTGATCTCACCACTCCCTA

[0182] ACATTGTTGTCTGTTGTTATCTTCACAAATCCTCCTGGACACTTTGGAGCTACTTGTTTTCTGAGCCC AGAAGCTGTCAAGATTCCATCAGGTTTCACTTGGCTCTTTTCGCGCTTGCACTACTGGCACTTTTTGG CTAGTCGTCCATTGTGCATTCACACCTCTTTATTCCTACCCATTTTTATAGGTCTGATTGATTTCTTAG

[0183] TGTTGTCCTCCTTTTTGTCCTATTTTTTTCCTTTTCCTTTTTCCTCTCCAGTCCTTGCTTCTCTCAGCCT GTTTTTGCATTAGTCAGCCTCTTAGCACTGTGTCAAATTATTTACGTTTTTTTATTACATAAAATTTATT

[0184] ACAAATATTTGGTATTTTATTACAGAAAATAATACTTTATTATGCTTTACAAATAAGATATGGTATAATA ATTGTGGTTTACAGTTATTGATTAGGTAATGTGACTTACTCTGTTGACTTTGCTCGAAGTTCTCTTTGC TACTTACTATTAACATCTAATTTCTCAATTCTCATAACATCTCATTCTCTCTGCAATTTTTTTTTTGCATC ATCATCTTTGGAAATTCATCCAATATGCTTGCTTTATTCAGCATCAGCTTGTTTATGATAATGTTTGTTT TCTACTCTTTATATCATCTTTGTTACATGCCCAAAATGTGTTCTGTACCATCATTTGATCTGTTCTAAAA TTTCTCATTTTTAAGTTTCTTAAAATCATTCCACTTTTCAGTATGCATTTTTGCTTAGATCAGTTTCCTC

[0185] TCATATCTGTTCCTTTCCCCCAGCTTCTTGATTTCTAAGGAGAAAGCTCTTCTCTACTTCAATTTCCTA GTTTATTCTGTTTCCCTTGTTTCCAGTTACCATTCATTTTGCCTTGTTTCCTGGCTTTTGGTACTTAACT TTCTGAAGCTTCCTCTTTTCTTCTCCACACCTCCACGTTCCTTCTTATTTATAAACATCTTTGTTTCCTT TGACATGGAAATTTATTTTTAGGATACATTGTTTTTAATGGATAAATACTAGGGGTCACATCTGCTGTC TGTTTTCTCCAGGAATCGGATATGCCTTTGTCTTAACCAGGCACAGGTGCCTCTGGATTTTATTTTAC

[0186] TCTGTAATAGATGTGTAGTTTTGTTGAATTGTATCTTGTTTGAAGACTACTACAGAGTGGAACAATGA GTGAAGTAATAAGTAGGGGTTATGAAATTGTAATTCTCTGATTATAAAATTGTTTATCTTGGGAACTTT

[0187] GCTGCAGAGTTATTAGAACCGTTTGCAATTCTGTAAAGAAGGCTTTTGTGAAGTAAAATCTCTACCCT TCTATTTTATTTGAAAGGGCCAGATTGTTTGGAACTGTACCCCCTGAAGAGTCTGATTTAGTAAGTGA

[0188] GAGCGAGGGCCATGGATTTCTGTATTTGGCACATGTCTTGAGCAGTTCCCATGTACCAATCCTTGAG AACCTCTAGG CTAGCTG AATTTAAGTATAAATTG CCAGTAATTG G AAAG CATATTCATATCTTCTG AAA CTATAAGGATACTCTCATTTTACTTGGTTAAAAAACAAGTGTTTCCTACTGTCCTCTTTACCCAGGTTT TAATGTTTAGTGGTGAACAGTAGTTTTCCCTCTACATTTTTTTCTGAACTGATAATAAATGTATTTGGC

[0189] TGGGAGGGTGACATTGATTAAAAAATGTATCTCTTGAATGTAAATATCAGTATTACAGATGATAAAATA AATTCCTCCAAGAAATAATTTTAAATTTGAAGTTGATATTCAGTGGAAACTGAAATGTGCTGTGGTCTT TTATTTG AAGTCTTCCTTACATTCACTTAAAG GG ATCTTTTACTG CAAATTACATG G AAAG AATG AAAA

[0190] GGTTTGCTTGTGTGTAATGACACATTTTATTCTGAAGATTTATTTTACCTAACAGTAAAATGTAGGTTT

[0191] TTTTTTTTTAAATAAAAGTTTCCCAGAGGGAAATTTCATCTAAAAAAAAAGTCTGATTTCAAAGGGAAA

[0192] GCAAGTCATTATCAAAAATTAGAAAACTATAAGTACAAAAAGTAAAAAATCATCAGTAATTTTGCCACT

[0193] AAGATATTATTACTATAGACATTTTGGTGTATTCCATCTGTTCTTTTTTAATGCTTTTATAACACTATGT

[0194] AGTTTTGTATTTTAAAAAACTTAAAGCAAAAATTTCTACGTATTATTAGACATACTGTGATTTATTTAAC

[0195] TAATCATTTTTTTGGGGTGTTAGGTTGTTTTTAATTTTTTACTGCCATCAAACATCTTGAACATAGGAT

[0196] GTAGATTTTAGTCTTTAAAATATGTTGGGGAATGAACAAATTTCACATCCTGTATTTGTAGTATTAATA

[0197] CTTTGTAGGTGCTCAAAATAGAATATTCTGGTAAATGATTAGTGCTTATTAAATATTTATCAAATGAAT

[0198] GTACTTGTACTTTTGGCATTAAACATTAACATCTGACCATTTATATTTACCTGATTTTTTTTCTATGGCC

[0199] ATATGGTATGAAATAGTGTATGGTATAAATTAACCATATGGTATAATAAATACATTTTTTTAAGTGTGAT

[0200] ACCAGAGTGATATTTATTAACTGTTCTTCCTGTGCTGTTTCTGTAGAAGGGAGCTTCTCACAATTGCA

[0201] TTAGAATTACAATTTTATTATGTTCTGTTTTCAAGATCTCTGATCGTCAGTCTTAAACTGTTTAATTATA

[0202] ATAATGTATTGACTAGGGAATATTCTGGGATATAATCTCCTTTATAATGAGGTCCACTGTATTAAAATA

[0203] CATCTTTGCAAGCCACACCAGGTTGGATTGCATCATAACCCTGAAAAGTGGTATTCTCATTAATGCAG

[0204] GTGCTTGTGCAGTTTTGGCTATTGCTGTTAATACTTATACAGATATATTCACAGGTGCCCTTGTGGCA

[0205] AAAATCATAAAATAGTTGTTTGTCTTTGGTATTTCTAGTGTTCACTTTCTATATTCTTTTCTCTCTCCTT

[0206] ATTTACTGAACTCCCTTCTTTAGGCATCCACTCACTCCTTTTTCTGTTTAGAATATTATCTGTCAGTCA

[0207] TTTTATATGTTGGCCATTAAAGGAATAAACTGTCAGTAAACAGCTAAGAAAGGAATGTTGGACTGGGT

[0208] GCTTGAATCCTTGAATGTAGTAAATGTGAGTGCAAACTTGATTTAATTGTACATGTATTTGGATAATAG

[0209] GCCAGAAAAATTACATTAGGGTAACAGGCTAGAACAGTCTGACTTTTCTTGTTTTTCTATCCCTTGCTT

[0210] TCTTGATTAGAATGAATAGGAGGTGGGTCTGGATATAGCAGCTGGAAACCTGTGTTCCATGAGTGAT

[0211] GGGGAAGAGAGGGAGGGAATAGGTTCCTCTGATTTTTGGCATTTTCTAAGACCTGATGCCCACCTTG

[0212] TCAGAGAATGCGATGACTACTTTTGTGTTCTTCCTTTTCCCTTTTTCTCCCAATTATAAAATTGTTTTCT

[0213] CTTTCAGAACTGCAGAAGTGCATTTTGTTTCTTTGACACTTTGATGTTGTTAATTTAGCTGAATACCTA

[0214] GTGAACATTTTGTGTCATAATCCCCTTGTTTTATGAAATCCAGTATGGTCTAGTCACCTTACATTTCTG

[0215] CCTCATATTGTCCTTAAGCCTTTTTTTGTCAGTAGCTCTTACTAGATTTTGTCTTCATCAGAAGTTAAA

[0216] GTGTTTTAAGTCCTTTACTCATTCTGTTTCTCTATTTTAACTTACATTGGTTATTCTGTAAAGTCAGATG

[0217] TGGCAGTAGGGCTGGTCGTGGTGGCTCACACCTGTAGTCCCAGCTACTTGGGAAGCTGAGATGGGA

[0218] GCATCACTTGAGCCCTGAAGTTCGAGGCTGCAGTGAGCCATGATCGCACCACTGCACTCTAGCCTG

[0219] GCAACAGAGTGAGACCCTGCCTCAAAACAAACAAACAAACAAACAAAAAAAAAACAAAAAAACTTGCT

[0220] TGTAGAACTTCTGAATTCAAAATAGGTGGGCCTATTTGGGAGCTTTTCTGTTTTTAAGGTGTCAAGTA

[0221] CTGCTTTTTAAAATCATAAGGTTATGGATAACTTCATGTTAGTGTAAGAAGAAAAATATAGCCTCATTT

[0222] GTTCCATTTCTTTCTTAAATTTTTTGTTTTCATTGCCATGTTTTTATTTTTCGATTTCAATTTTTCCAGCC

[0223] TAAATCACTAACATACTTAATTAGCATGGTAATCAGAAGATACTCTTTAATACAGTCTCCACCCTAACA

[0224] TTAAGCAATTATTTTTCCCCCCTACCCTCTGAGATTATTTTTGTGTCCATGTTTTCTCTTGGGCTTAAA

[0225] AAAAAAAACTATTATTCTAATTCCTTCCTGTATCAAGACTATGCATATAGAGGGAACTCAATGCCCAGT

[0226] AACTTCTTTTTCTGGGCCCTGGTGATGTAGAATATAAAAATTGCTTTGAACTCAATTAACTTTATATCT

[0227] TCTGGAAGCTCTGTAACATCGGATAAAGCGTCGTTTTCATTCTTGTAATGTAGCTGCAGTTCCTGACA GCACGTTTGGGACAAATGTACTGTGGGACGGTGGTTTTCAAAGTACGCCAGAGCTCTAGGAGAATTT TTCGAAAACATTCTATCATTGTAAATAATAATTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTCGCTCTG TCTCGCAGACTGGAGTGCAGTGGCGCGATCTCAGCTCACTGCAAGCTCTGCCTCCCGGGTTCACGC CTTTCTGCCTTTCTCCTGCCTCAGCCTCCCCAGTAGCTGGGACTACAGGCGCCTGCCACCACGCCC AGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTGGCCAGGATGGTCTCAATCTCCT GACCTCGTGATCTGCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCACACCT GGCCAGAATAAAAATTCCAAATTGCACTAATGCATATGTGAAACTGTTTTTGTCTGTTTTGTAGTTTTA AAATCTTCATCTATAATAGTACCTGG CAC ATAG GTACTAAAATATTTG GTG AAAG AATTAGTG AATAAA ACCTTACTGGATATGAGGTGATCTGATTTTCTGTAACATTCTATTCTTTTTTTCTGCCGGTCACAAAAT CACCTTATGAAATTGACAGCCAAATTGGCTGCAACAGGCAGTTTGAAAAACACTGTTTTGGGGTTTCA AGGACCTTCTTCAGAGGTTACCCCAGGGCTCTGTTTAGTGCCTCTATACCAGGGGCCCCCAACCCC TGGGCCACAGCCTCGTATCTACCAGTCCGTGACCTGTTAGGAACCTGACTACACCGCAGGAGGTGA GTGGCAGGCAAGTGAGCATTACCGCCAAAGCTCCACCTCCTGTCAGATCAGCGGCAGGAGCGTGAA CCCTATCAGAAACTGTGCATGTGAGGGATCTAGATTGTGTGCTTCTTGTGAGAATCTAATGCCTGAT GATCTGAGGTGGAACAATTTCATCCTGAAACCCCCTCTACCCCTGTCCATGGAAAAATTGTCTTCCAT GAAATTGGTCACTGGTCCCAAAAAGGTTGGGGAGTGCTGCCCTATACCATAACTATTGAAGTTCTTC ATTTATCTGCTTTACATGTTAGTTTCCTTGAAAAAAGGGTTTTATGGCTGTAAAAATTTTAGAGCTACT ATGTATGGAAGAGAGGTTTGTGCTGGCATAAATCTTCTCAGGTATCATCTGTGTAGAAAATTTCAACA ACTTGTGTCTTAAGGCAGAGGTCAGCAATCTTAAGGGTCAGATGGCAAATATTTTAGGCATTGTGGG ACATACAGTTCCTCTCACAATTCCTCAACAATACTGTAGTAGCTCAGAAGTAGCTAATAGACAATATTT AAACAAATGAGTTTGACTCTGTTCCAGTAGTCATTTTCAGGACACTGAAATTTGAATTTCATATCATTT TCATGTGTCATGAAAATCTTCTTTTGATTTTTTTTCTACCACTTAAACATGTAAAAAGTATTCTTAGCTT GTGAGCTATACAAAAGCAGATAGTGGGCCAGTTCATGGGCTGAACTGTTCTGACTCCTGGTCTAAGG GAGACTATATATGTTATATTTGAGGTTCTCAAAGTAAGATGTAGGTTAGAGGTCTATAGAAAGTTCATA ATTGCTTTTGTAAAAACTAGATTGATTTATTTGAGAGGGAGAGAGAGGTGGAGTTTCACTGTATTGCC CAGGCTGGACTTGAACTCTGGGCTCAAGCAATCTTCCAGCCTCAGCCTCCCAAGTAGCTAGGACTA CAGGCATGCACCAAGCCCAGCTCCTAGTTCCTCTTTGCACTCAGTTTCATCTTCTACCCTCAGCCCC TGGCAAACACTGGTCTGATCTCTGTGCCCTTTCCAGAAAGTCATATAAATGGAGTCATATAAAAGTCA TATCAGTGGGGCCGGGCATGGTGGCTCACACCTGTAATTTCAGCACTTTGGGAGGCTGAGGAGGGC AGATCACCTGAGGTCAGGAGTTTGAGACTGGCCTGGCCAACATGGTGAAACCCCCTCTCTACTAAAA ATACAAAAATTAGCCGAGCATGGTGGTGGGCACCTGCAATCCCAGCTACCTGGGAGGCTGAGGCAG GAGAAACACTTGAACCCGGGAGAGGGAGGTTGTAGTGAGCCGAGATCGCGTCATTGCACTCCAGCA ATTGTGAAGCAGTGGTTAAGGTTCATTCATTATTTTACATATGGATGTCCAGTTGTTTCACATTTATCA AATTTCTTTTGAATCACCTTGGCACTTTTATTGAAATCAATTGCTTATGTTTGTGAGTTTTGGATTCTAC TGTTTTATTGATCTGTGTGTGTTTTCTTAGGCTAATACCCCACTACCTTAGTTATGATAGCTTTATAGT

[0228] TAAATTTAAAATCAGGTAGGTCCAGTTGAGAAGATTTTTAGAACTTTGACTTTTTAATTTCTTGTTACCA TACTTTTGGAAGGAGAAGACTCATAATTTTATTCAGGTTTTCAAAGGTGTCTTCTACCCCCAAATACTT AAGACTTCAGTATATAGTTAATATATCTCTGTCTTGAATTATGTGGTGGTGAGGTTCATGAAAAGTGA CAGGTAAAAGTTGCAACCAAAATTAATTTCCTTATAAGAAAGGACATATTTTAGTAGGTTGCACAGAA AAGTCAATCACGTCCTTTTTACCGTGTTGCATTATGAGGTGTAATCAAAATGTGTATAGGGGAAAATG

[0229] AATATGTTAAGATGTTTATTCACCAAAAAAAGTCACCGAAAGTGTCAATTAGGTTGTGAAAGATACTA

[0230] GTTTACAATGTGTTATTCTCCATCTTCATTAGAAGAGTTCTTCCATTTGAAACCTATGTCATGTTCTGT

[0231] GATATTTCAGAGTTAGTATCTTTATGAATCTTAGGGGCATCATTAAATCATTATGTTTCTTCTAAGGAA

[0232] AGGCATATGGTAGTAGTTGGTCATATTTCTACCTTTTTCAGTGGGGCCTATAGGGCCCCTTTACTTTG

[0233] TTTTAAACTGCACTGATAGCTTTTTACTGGTTAGCCCAGGGAATTATCCCTACAGTGTAAAATGATGTT

[0234] TCTCATCATGATTTTCATTTAATAATTTAAAAACAAAATAACAGGAAACACATGTTTCTAGAGAGGAAG

[0235] TGTGGAATACCTGACTAGTAGAGGGTCAGGTGACAATTGCGAAGGTAGAAACTGACTAAGTTTTGAC

[0236] CATGTTGCAAGGAGTATCGTTCCAGTTTTGTTGGGTCACCTTGCAGAGTTTTTAAAAAAAATCCTTGG

[0237] GTTTTTTTTGTTTGTTTGTTTGTTTGTTTTGGTAGAGATGCTGTGTTGCTCAGGCTAGTCTCGAAATCC

[0238] TGGGCTCAAGCAGTCCTTCCCAGAGTGCTGGGATTACAGGCATGAGCCACCGCACCCAGCATCACC

[0239] TTGCCGATTTTGAAACTACACTTCCAGGGAGAGAGTAATACAATATCTTGGCAGACTATTTTTAACTAT

[0240] TGTTCCAAAATTAATCTGTTTTTAAAAAGTAAAGAAGTGTGGATATCTTTAAAAGATACTTTAATTAGG

[0241] CTGGTCACGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCAGGATGGGTGGATCACCTGA

[0242] GGTCAGGAGTTCGAGACCAACCTGACCAACATGGAGACACTCCGTCTCTACTAAAAATGCAAAAAAT

[0243] TAGCCGGGCATGGTGGCGCATGTCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATTGCT

[0244] TGAACCTGGGAGGCGGAGGTTGCAGTGAGCCGATATTGCGCCATTGCACTCCAGCCTGGGCAACAA

[0245] GAGTGAGGGAAACTCCGTGTCAAAAAAAAAAAAAAAGATACTTTAATTATATTTAAGTTGGGGAATAC

[0246] TTTTGTTTTATATTTTTTCTTGCACTAAATATGTAACCTTTAAGTTAATAACACCAGAAAATTTTTACTTT

[0247] ATAGTTTTAGAACTGCTTAATTGAAATAAAATGTTAGGATACTTTGAATTAGTCACTTATTTTGGCATAT

[0248] TTTAAACAGTTTAATGTACTGCTTGGGGTTGTTTCTCAATTGACTTGATATTTTTAAACTGTATTTTTTA

[0249] CCTTGTACCATTTATTTTGCAAAATAAATTTCTATTTTGGCTTATAGATGTATTTTTAATATTAAAGGGG

[0250] ATTATTGGTGTCAGCCATAAAATTGTAATTAAGTCTTAAGTAGGTATGGTTTTTTTTTTTTTTTTTTTTTG

[0251] G AG ACG G AGTCTCG CTCTATCATCCATG CTG G AGTG CAGTG GTGTG ATCTCGG CTCATTGCAACCT

[0252] CCGCCCCCCCCCCCCCCCGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCAGAGTAGCTGGCACTAC

[0253] AGGCGCATGCCACCATGCCCGGCTAATTTTTTTGTATTTTTGGTAGAGATGGGATTTCACCATGTTAG

[0254] CTAGGATGGTCTCGATCTCCTGACCTCATGATCCGTCCGCCTCAGCCTCCCAAAGTGCTGGGATTAC

[0255] AGGCATGAGCCACCGTGCCTGGCTGATTATTTTTATAGAGCTCTTGTTAGCGTAATTTCTGGTAATGT

[0256] TTTATGGAGGTGACTTAATTCCCATCATAAAAATATCCCATCTTTTCTGTGACTAGCAAGCAGTTATTG

[0257] CCTTTATAACTTTTTTTTACCATAAAAAGATAAAGTACTATTGATAATTACTCCTAATTAACTCAGAACT

[0258] TTTTTGTTTTACACACATTAATATATACTTCCATGGGAATAGTGTCAGAGAACATCAAATAGGGAAGAG

[0259] ATTATGATTCAGAGTGGTCTTTATATTCCTATTCTAGAGCCACAGAAAATGTTCATCTCCCTTTAGTTT

[0260] TTGCAGGATTGCCTCTAACACTGATGATATTCCACTCATATTCTTCCTGCACATGCCTTCTCATACTAA

[0261] CAGTAAGTCACACAATCTCAAATAAGTTTCATTATACATGAGAACTCAGTTGAATGCTTGCCTTTCACT

[0262] GGCATCTCTTGATCCTCCTCCCCCTCCTTATGGTATGCACTGAACTTCTAGTAGGCCATATGTGTTAA

[0263] GTAGATCATAGGAGTGCTATGAAAATAAAGTGAAATGATGAATATGTAAAAGCCTTCACAAAATTATA

[0264] GTAGTGTTTTCTGTTGATTTTTAAGACAAAAGATAAATACTATGTATGTAAAAATTTCCTTTCAGAAATC

[0265] TTTGTTCTTTTTTTTGTTTTGAATGTTCAATATGCTTAGCACAGGGCTCTAGTTAACACTTTTGGCAGT

[0266] TCTTAATGTGGGACTGACTGATGATTGTCCTAGAACTGTTTCAGTGTTAACTACATTCTATTAATGTTA CTTTAAAACATTATTTAATTAAAGAAACATGAAGTGGCAACATACTGATTCATGTGTTCAGTAAGCAAT TCATGGGAAAGAGGTAAGCTTTCTTAATAACAGTAGAAAGACTGTTCCATTTATAGGAAAACTGGTAA TTATGACTTGTGTTTTGGTATTTAAAAGCTGTGGTTGGCCGGGCGCAGTGGCTCACGCCTGTAATCC CAGCACTTTGAAAGGCCCTGGCGGGTGGATCATGAGGTCAGGAGATTGAGACCATCCTGGCCAACA TGGTGAAACCCCGTCTCTACTAAATATACAAAAAATTAGCTGGGCCTGGTGGCATGTGCCTGTAATC CCAGCTACTCTGGAGGCTGAGGCAAGAGAATCGCTTCAATCAGGGAGTCGGAGGTTGCAGTGAGCC AAG ATCG CG CCACTG CACTCCAGCCTGG CTACAG AG CG AG ACTCTGTCTCACAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAGCTGTGATTAACATTTGCTTTGTCATTCATCCAAAACTACATTGGTGACTTTTG TATTGAGTCATTTCTTAGGGCAACAGGTATTCATGTATTCAGTAAATATTTGAGTGCCTACTATATGCC AGGTAGTGATCTAGGTGCTTAGTAGTACACTTGAAAACAAAACAAAGGTCTCTACCCTTATGTAGCTG CTGTCCAGTGGAGGGGTGTGTGTGTATTGGGGGATGGGGCTGAGAAACCTTAGACATACAGAAAGG AAATTATGTAGTATGTTCAAAGGTAATAAGTGCTGTGGAGCAATGAAAGTTAAACAGTTTAGGGCTGG GATGGGGGTAGGTAGCAATTTAAATAGGGAGGTCAGGGTAGGCCTCACTTGAGAAGGGGGTATTTG AACAAAAATTTGAGAAAGGAGGAGGAGGCATTTCAGATAAACCAATTAGTTCAAAGATTCTGTGTCG GGAATGTGCCTTGCCTATTTAAGAAACAGCAGGAGGCCAAAGTTGCTGGGGCAAGGTAGAGACTAG GGGATTAGGGAAGGATCTCTTTCAGTTATCTAGGCCATATTGGTGATAGCAGAAATACTGAGAAGTA GTCAGATTTTGGATGTTTTGAAAGTAGATTCATCGGGGCTTGGTGGCTCACGCCTGTAATCCCAGCA CTTTGGGAGGCCGAGGCGGGCAGATCACCCGAGGTGAGGAGTTCGAGACCAGCCTGACCAACATG GTGAAACCCTGTCTCTACTAAAAATACAAAAATTAGGTGAAATATTGAAGGAGATGTTTTGATTGAAG TGATTTTAAGAGAGAAGAGGAGGGGAAGTAAAGATGGTGAGGAATTATCCTGTAAAGGGGAACAGA GAAATGGGGCCAGAGCTAGTGAGGAAAGTGGGGTCAATAAATTTTTAATGATAAGAAAAAGAAGAGC GTATGATGATAGGAATGAGCCATTAGAGAGTAAAACGTTTCAGGAGGGAGAGAGAAGAATTGCTGAA GCACTGTCTTAGAAGAGGTAAGAGGGAAAGGGATTTAGTGTATAAATAGGAAGGATTGGCTTTCTAT AGGAGCATCTATACTTTATGATAATAGGCCATTAAGCAGAGTATGTGGTTAGAAATGCTGCTAGGAAG GTCGACGTGATTGGTGGAGTCTGTACACGTTCTGTTGCAGTTGCTTTGGTTTTTTTCAGTGAAGTAAG ACTTGAGGTTATCAGCCGAGAATGAGGATTGGGGATATGTGAAAGTAGCTCCGCAGCAGTATGGGA GCATAAATGAACTGGAGACAAATAGTAAAATTAATGGGCAATTTTTTTTCCTTTAAGAGATGGGGGTC TCACTCTGCTACCCAGGCTGGGGTGCAGTGGCACAGTCATAGCTCACTGCAGCCTCCAACTCCTGG GCTCAAGTGATTTTCTCACCTCAGCTTCCCGAGTAGCCAGGACTATAGGCTAATGGCAATATTAAGTT ATTTTATGAGTTGTCTAGACAGCATTATGAGTCTCCTAACTTTTTGGTACTGATCTTCAGATCAGAGTT AAATGTAACTTGCCCAGGCAATTTAAACACTCAATATGAGTCATTTTCATTTGGACTCAAACATGGAAT CATTGGGAAATAGAACATGAATTTATTACTCCTTAATGAAGTACCTGCCACTATCCTGCCATGAATGT AGGCTAAATTTGGAGTGGTCTGGTAACTGCTTTTCTTTTAAAAAAATTTTCTTCATCTTTTCTGTATCAA

[0267] ATACTTACTGGTTTTTCTATGTAGAATAACATAATCTCATCATTACTTTCTTTCAAACACTCTCCAAATT TGACTTGTCTTTGCTCATGTTTTTCCTACCACCTGAAATACAGATTTCCTCCCCCATCCCACCCTCCA AACCTTCCAGACTTACCTCACCTACCGTTTATTGTAGGAAGCTTTTCTTAACCTCTTTCCAAGTCCTAG TTTGATGCCTCTGCTTTGTGCTTTTGTAGAATCCCAGAGTTTACCTTGTTTTACTCACTATATCGTATT GTGGGGTTTTTTTGTTAATAGGTATTTCTTTTTCCTCTAGACCTGCACTGTTCAGTCATACTTTCTGTG ATGATGGAAATGTTCAGTGTCGTCTTAATATGGTAGACAGTAGCCGTATCTATGTGGCTACTGTGCAC TTCAAATTTGCATAGCAGGACTGAGGAACTAAATTTTATTTCATTTTAATTAATTTAAAAATAACTAGCC TGATGGCTAGTGGCTGCTTTAATCAGTGCAGTTCTAGACCCCTTCAAAGTCAAGAGTGTGTGGGATT CATACTTATTCTCTCGTTGCTTAACAATAATACTGTCTAATACTTAAATGACTGAATTCTTTTTCGGTAC TCTTAGTCTGCATAGTTATAACTCACCTAGAATATGGCAGTTTTGTTCTCTAGATTTCTGTCTTTAACC ATGGCTTTTCAGTTTGTTTTCAAGATTATGTTGATTTACACAGCACTGAGTTCTTCAGTCCTGCGAAGT TAGCGTTTTGGTTGGATGTGGTGGCTGGCATCTGTAATCCCAGCAATATGGGAGGCTGAGGCGGGA CGACTGCTTGAAGCCAGGACTTTGAGATCAGCCTGGGCAACATAGCGAGCCCCTGTCTCTACAAAA AATTAGCTGAGTGTGGTGGCATCCACATGTAGTCCCAGCTACTTGGGAGGCTGAGGGCGGGAGGAT TGCTTGAACCCAGTTCACGGCTGCAGTGAGCTATGATCACACCACTGCACTCCTGCCTGGGTGACA GAGCAGGAGTCACCCTCTCAAAAAAAAAGTGTATTTTTTCCCCTTTAGGACTGAAAAAATTGGGTGTT ACAAGATTACCTCAAGGACTGGTCTGAGAACTGGGGATGGTAAGGAAGAAACTCAAGTGGCCAGCC TCTGGTTTGTGGGGGTAGGTGGGCAATTTCTGTTTCAACCAAAGCAGTTCTACTTCATAAATTAATAT ATTGGAATTGTGCTTGGGATTTCATTTGGAGGGGAAAAAAGTCTTCTAAACAATAACACTGTTAATTG AAGAGACAAAGCATGCATATGGCAGCACGTGATTAACCACCAAAGTGGATAACAGATCAAGAAGACA TGGGAAGTTGTTATGGGCTAGTGAGGTCTTGATGGAAGTTAAGGTTTAATTTAGGTAGGTAGAAGGA AGACAAAAGGATGTAATAGGCAGTGGGAATAGAATTTGCAAAGAATTGGAGTTGGAAATACATATGTT AGTTTTG GTTAAG AAACAATG AG CTG ATTATAGTTG AG CAAATTGTATG AAATAAAATTTG ACAAAATT AGATGGGACTGGATTGTAGGAAAAAGTGATAGGCTGACAAAAAGTGCACTTTATATTGCATGCAATG

[0268] AGATGAAATACTCGGAGGTATTTTGGTTGTTACAAAGATGGAGGAAGAGGACACTATTAGCATTTAAT GAGAAAGGATCAGGGAAGTCAGCCATCCCACAATGTTCAGGACAGTTTGCACATTTAAGAATTGTTC CAAATCACCACATGACCTAGAATGACTTGCTGGACTTTGATGATGTAGGTTAAAAAAAAAAAGTGATC ATAATGATGTGAGCATAGACAGTAACTCCATTTTGTGTATGAGGCACTTTTTTGTTGTTGTTGTTGTTG TTGTTGTTGTTGTTGTTGTTTTG AG ACG G AGTTTCG CTCTTGTTG CCC AG GCTG AAATG CAGTGG CA CCATCTAGGCTCACTGTAACTGAGGCACCTTTAATATACACTAAGATTTTCAGGAATTCAGTTACCAC AATATTGGAGGAATGTTAAAGTTTTTGTTCAGAACTTTATCAGGAGTACTCCACCCCTTTAGAAAATCA CGTAATTGATGGCAGTGTCACTTGTGCTGTATTGGTGACGCAAATACTCTTCAGTCTGCAGTTGTAAC TGCCACAGTCACAGTGCTTGTTGTATATATGTACAAAGTACCATCAGTGTGTTATTTATTATAGTAATA GCCTAAATATTATAAAATTGCACTAAGGTAGATTATCTCTGAATTACATTTATTTTTTATTTTTATTTTTG TGACGGAGTTTTGCTCTTATTGCCCAGGGTGGAGTACAATGGCGTGCTCACCAAAACCTTCGCCTCC CGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCATGTGCCACCATG CCCGGCTAATTTTGTATTTTTATTAGAGACGGGGGTTTTCCATGTTGGTCAGGCTTGTCTTGAACTCC CGACCTCAGGTGATCTGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAACCACTGTG CCCAGCCTCTGAATTACATTTAAGGGTAGTATAGAGAATGTACAAAATAGTTGTTGTAAAAAGGAGAA ATTGATTTCTGTTTTCAGTATTGGAAGACTGGGTTATTCAGATGAAAACAATTAAAATTCTTGGAAACA GTATTAAAAAAAAAAAAAAAAAAAGAAAACGTAGAGCAGTTGCAGAGCTGAAAAGATAGTGGGGAGC TGCCAGGCCAAATTCTAGGAATAAACAAGAATCCAAATAAATAAGTGGATGAAGTAGCTTTTGCCCTA

[0269] AAGGCAGTTGCCAATCTGTACAAGTTGGGCTTTGGTTTTGGTGGACCATTGGGGTGAAGAGGACAG AAATCAAGTCCTAGAGTTCATCTAAAGTGACAGTCAAAAAGAATAACCTCAGTTTTAGATGGGACCCC AGTGACTCTATCGTTAGGTTAAGGGTGAAACAACTGAACTGTCTACACACTCCCATATCCATGTGATT GCAGGGAAGGTTGAATGGAGCAGGAGGAGGAAAAGGAAATTAAGAAAAATAAACCTTTCAAGTTGTG ACCACAGTTTTAGCCTTCACAGTGATTTGCCTTGAGGGTTTGCTCTGTCTGGGTGGTCCAGGGACCC TCCATGATAAATGACCCTCCAGCCATTTATCATGGTTACTGGTTTCAGACTAGTATTACTTCCATGGC CTGGCAGATGGAAAGGCAAATCACGTGTGGAGAAAGGCCTTTCATTCTAGGGAATTGCTTCCAGTAA TTTTTCAAGGACAATGAACAGTACATTGTCACAAGTAATCAAACATAGTAAAAATAAAAAAATTAGCAA GCAAAATTACCTGAGAGATATATAATATGTAATATATATGTAGAATTCTTTCAGCAATGTAATTAAAATT TGTGTGGGTTTCTTTATGTATATATACCTAAAATTACGTTTTTACAGAGGAAAAATAATAACCAAGCAT GCATCCAATTGGCACTGTGAATAAGAAGAGAGCAGAAACAGATCTATAAAATCTTCAAATGTTGCAAA TATCAGATGGATTTAAAACAATCACTGTTAAATTTAAAGAATTGGAGACAAACTTGAAGAACAAAAGAC TCTTATAAAGTGACTTAGGGCCAGGCACGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCC AAGGCAGGCGGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACTTTGTC TCTACTAAAAATACAAAGATTAGCCACGTGTGGTGAGGTGCACCTGTAATCCCAGCTGCTCAGGAGG CTG AG GTG G G AG AATCACTTG AACCTG GG AG GTG G AG ATTGTAGTG AG CCG AG ATGG CACCACTGC ACTCCAGCCTGGCCTATAAGAGTGAAACTGTGTCTCAAAAAAAAAAAAAAGTTACTTTGGTTCATGCC TGTAATCCCAATACTTTGGGAGACTGAGGTGGGAGGGTCACTTGAGGCCAGGAATTTGGGACCCGC TTGAGCCCAGGAGTTTGAGGCTGCAGTGATGTATGATTGTGCCACACTGCACTCCAGCCTAGGCAA CAGAATGAGAAACTGTCTCAAATAAAGGAAAAAAAATGGCTGGGCACGGTGGCTTATGCCTGTAATC CCAGCACTTTGGGAGGCTGAGGCCGACAGATCACGAGGTCAGGAGATTGAGACCATCCTGGCTAAC ACAGTGAAACCCCACCTCTACTAAAAGTACAAAAAATTAGCTGGGCATGGTGGCAGGCACCTGTAGT CCCAGCTATTCGGGAGGCTGAGGCAGGAGAATGGCGTGAAACTGGGAGGTGGAGCTTGCAGTGAG CTGAGATCGCACCACTGCACTCCAGCCTGGGTGGCAGTGCAAGACTCTGTCTCAAAAAAGAAAAGG GGGGGAAAAACCCAACTTAATAGATTTGCAAAAAACCAAATAGAAATTCCAGAAGTGAACACTTTACC AAATATACCTAAGAGATTATGCCTAGCTGAAGAAAGAGTTCATTGCCTGGGAGACAAGGCAGAAGAA ACTGTTTAGAGTGTAGCACAGAATAAAAAAGAAAATATTGAAGAGAGGTAAAGAGACATGGAAGACA GAATAAGATCTAATTTCTTTAATCAGAGCTCTGGAAAGAGAGGAGAAAGAATGGTACAGAAGTAATAT TTCAAAAGATATTTCTGGCTGAAAATTTTATAGATCCAATGAGAAACCAGTTGATTGATTTAAGAAGGT TAATGAATTTCTAGCAATATAAATAGAAATCTACACCCAGACAAATCATAGGAAAACTGCATAAACCCA GATACAAGGAGAAAAGTCTTGAAAGTAGCCAGAGAGAAAAAAAGATGTTTTTCAAAGAAGCAACTAT

[0270] GGACTGATGGTTGACTTTTCAATAGAAAATTACATATATTCTCAAAATAACTGCCAATCTAGAATTCTG TAATTAGCAAAGAATTATCCCTCTACAATGAGGGTAAAATACTTAGTTGAACAAACTCCATCAGCTCTT TCTAAAGGAAATTATGAAGTATACATTAATACTTAAGGCAGAAAGATTCTAGATAAAAGTCTGAGGTG

[0271] CAAAATGGAATAAAGAGCAAAGAGAGTGGCAAATATGTGGATGTATTAAAAGAAACGTTGACTGTATA AAGTACTAGTAAGACCTTAATTAAAATATGTGACAAGAAGCTGGGCATGGTACTTTGAGAGGCTGAG GCGGGCAGATTGCCTGAGCCCAGGAATTTGAGACCAGCCTGGGCAACATAGTGAAATCCCGTCTCT ACAAATAATATAAAAATTAGCTGGGTGTGGTGGTGCATGCCCATAGCCCCAGCTACTCAGGTGGCTG AGGTGAGAGGATCGCTTGAGCCCAGGAGGTTGAGGCTGCAGTGATCCTTGGTCGTGCCACTGCACA CCAGCCTGGGCAACAGACTGAGACCCTGTCTCAAAAAAAATATATGACAGGCGAAGGCCGGGTTCT AAGACCTTTGTATTGTCAGAGAGAAAGGTAGAAAGTATTAATTGACTTGACCTTGATAAATTATATGTT TTAATTTCTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTCGCTCTGTTGCCCAGGCTGGAGTGCAGT GGCGGGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCC CAAGTAGCTGGGACTACAGGCGCCCGCCACTACGCCCGGCTAATTTTTTGTATTTTTAGTAGAGACG GGGTTTCACCGTTTTAGCCGGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCGCCTCGGCCTC CCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCCGGCCTATGTTTTAATTTCTAAGTTATCTT CTAAAAATGTAGAAACCAGACTTTTAACTTCTCAACCAACAGAAGATAACAAATGATTAATAAAAATTA ATCCTGAAGAAGTGAAGAAAAGAAAGAACCAGTAGGACAAGTAGCACAAAGATGGGTAGATTTAAAT CTAAACATATCACCAGCTACATTAAATACAAAATGGATTAAATTATTCAGTTAAAAGCCAAAGATTGTT ACACTGAATTTCCAAAAAAATTCAGTTATATGGGGTTTATAAGGAACATATCTGAAACCTAAGAATAAA G AAG ATCAAAAGTAATCATCACAATAAG ACATACC ATG CATATTCTAG CAG ACAGTATG GTACAGTTA ATATCAAAGGTGGACAGTAAGGCAGAAAGCATTATTGGCAGAAGAGTCACCTCAAATGATAAAATGA CCAATTCACTGTGAAGATTTAATAGCCTTAGTAATATAGTATAACCTGAAATATAGCTTTAGAATATTT ATAGCAAAAGTTAAACAAAACTACAAGAAATAGACAGATTTCTCAGTCTTAATGGGGTATTTTTAAACA GCTCTTTAAGTAACTGGTATAAGAAGCAGACAGGTTAGTTAGGATATAAAATATTTGTATAACACAAT GAACAAGTTTAACCCAGTGGGTGTATAGAACCCATTCTACCCAACAGTGGCAGGCTACACATTCTTTT CAAGCATGTAGGATTTTGGGGGGAAAATTGACTGAGTAATAATGTTGTAAAACAAGTTTCAACAAATT TCAAAGGATTGAAACCAAAAAAGCATTTTTTTCTGTCCATTTTCATTAAAGATCTCTATCAATAGGGTA ATTTTTAAAGCTTCATGTTAGAAATTGAGCAACTATTAATACTTGGAAATAATCTGGTCAGGCGCAGT GGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGCGGATCACGAGGGCTGGAGTTC GAGACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAATATAAAAATTAGCTGGGCGTGG TGGTGCATGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGACAGAAGAATTGCTTGAACCCAGGAGG CAGAGGTTGCAGTGAGCCGAGATCGTGCCATTGCACTCCAGTCTGAGAGAGCGAGACTCCCTCTAA AAAAAATAATAATCCATGCATCAAAGAAGAAATCACAATGGAAGTTAGAAAATACCTTGAACTAGATG ATTAAAAATTTTTGATTGATCAAATTCCACAACTTGATATATCTTAGACCATTGAAAGTGAGAGAATCA AATGTTATGTCTTTAGATACGAAGTTTCTTGACACCCCTCCCTGCCTCCCCCAAAAAAGAAATACCTA CCACCTATGAAAGATTCTTGATTGGAAAAAAAAAAAATAACTGAGCTGGAGTTTCATTAAACTTCTAGA TCTACTGGGAAATTCACAGTCATTTGATCTTTCAATGAGTCATAATTGTTTTGCTGTGGATGGTCTTGC CTCGATGTTGATGGCTGCTGGTTCATCCCTGGTGGTTACTGAAGGATAGGATGGCTATGCCAGTTTC TTAAGACAACAGTGAGGTTTGCGACATCAGTTGACTTCTTTTCACAAAAGATTTCTCTGTACCAGGCG ATG CTTTCTG GTAG CATTTG AACCAC AGTAG AACTG CTTTTAAAATTAG AGTC AGTCCTCTCAG ATCT GCCAGTGCTTCATCAACTAATTCTATGTAATATTCTAAATCCTTTGCTGTCATTTTAACAGTGTTTGCT CACAGCATCTTCAGCAAGAGTAGAGTTCATGTCAAGAAACCACTTTTTTTACTCATCCATAAGAAGTA ACTTCCCATTTGTTCAAATTTCATCATGATATTGTAGCAATTCAGTCACATCTTTAGGTTCCACTCCTA

[0272] AATGTAGTTCTTCTGCTGCTTCTACTACACCTACAGTTCCTTCCTCCATTGAAGTTTTGAACTCAAAGT CATCCATGAGGGTTAGAATCAACTTCTTCCAAACTCCTGTTAATGTTGCCAGTTTTACCTCCTCCCAT GAATTACAAATGTTCTTTATGGCATCGAGAAAGGTGAATTCTTTGCAGAAGGCTTTCAATTAATGTTG CCCAGATCCATCAGAGTAATAACGATATCTATGGCGGCTATAGCCCAATGAAAGGTACTTCTTAAATA AGGAATGTTGAAAGTCACAATTACTTCTTGATCCATGGGTTGCAAGATTTATGTGTTAGCAGGTGAGA AAACGTTCATCTTCTTGTAGCTCTCCATCAGAGCTCTTGGGTGACCAGGCACATTGTCAATGAGTAGT AATGTGTTAGAAGGAATCTTTTTTTCTGAGCGGTGGGTCTCAACAGTGGGCTTAAAATATTCAGCAAA CTATGTTGTAAAAGAATATGCTGTCATCCAGGCTTCATTGTTCCATTTACAGAGCACAGACAGTAAAT TTTGCAGAATTCCAAAGGCCCTAGGATTTTTGGAATGATAAATGAGCATTGGCTTCAACTTAAAGTCA CCAGCTGCATTAGCCTCTAATAAGAGTCATCGTGTCCTAGGCCAGGCGTGGTGGCTCATGCCTGTAA TCCCAGCACTTTGGGAGGCCGAGGTGGGCGGATCACCTGAGGCCGGGAGTTCAAGACCAGCCTGG CCAACATGGAGAAACCCTGTCTCTACTAAAAAAATACAAAATTAGCCAGGCATGGTGGCACATGCCT GTAATCCCAG GTACTCAG GAG G CTG AG GCAGG AG AATCGCTTG AACCCG G G AGG CAG AG GTTG CG GTGAGCCGAGATCATGCCATTGTACTCCAGCCTAGGCAAAAAGAGCGAAACTCCATCTCAAAAAAAA AAAAAAAAAAAAAGTCATCCTGTCCTTTGAAGCTTTGAAGCCAACCATTGACTTAGGGAAATGTTGTG GCTGGTTTGATCTTCTATCCAGATCACTAAAACTTTCTTTATATCAGCAACTAGGTTGTTTTGCTTGCT TGCTTTTCTTAAACTATTTTTCTTTTAATTCTTAGAGGGTCTCACTGTGTTGGCTAGGCTGGTCTCAAA CTCCTGGCCTCAAGCAATCCTCCCACCTTGGCCTCTGAAAATGCTGGGATTATAGGCATGAGCCGTA GTGCCCGGCCTGTTTTGCTTTCTTATCATTCATGTATTCACTGGAGTAGTGCTTGTAGTTTCCTTCAA AAACTCTGCCTTTGCATTTACAATCTGGCTGTTTGGTACAAGAGGCCTGCCTTTCAACATGCCTTCTT CACTAAGCTTAATCATTTCTAGCTTTTGATTTCAAGAGAGAGACATGTGACTCTTGGTTTCACTTGAAC ACTTAGAAGTCATTGTAGGGTTTTTAATTGGCCTAATTTCAATATTGAAATCTCAGGGAATAGGAGGC CCAAGAAGGGGTTAGGGCAGTAGCTGGTCAGTGGAGCAGTGAGAACACACACAACATTTACTGAAG AAGTTCACTGCCTTATATGGGTGTGGTTCGTGGCACCCCAAAAGAATTACAATAGTAACATCGAAGAT CATAGAACACTAAAATAGACAGCATAATAATGCAGAAGTTTGAAATACTATGAGAATTACTGAAATGT GACAGAGACATGAAGTGAGCATATGCTGTTGGAAAAATGGTGCCAACAGATTTGCTCGATGCTGGGT TGCCACCAACCTTCAGTTTGTAAAAAACAAACAAAAACCATTATCCGCTAAGAGCAGTAAAGCAAAGC ACAATATGATGAAGCATGCCTGTACAGTTTATACTTCACAGTCATTGGTTAAATTTACTCATTCCTTTA AGCATAAAAAATAAATATTTAGCACCTTTGTGCTGAGTTGTATGCTAGGCACTGGGATATAGAAATGA ATGATAGTTTGTCTTCAAGGAGCTTACAGTTAAGTGGTAGAAGTAGATAAATAAAGAATTAAGGACAG TGTACTGTGATGAAAGTGTGCCCCAGATGCAGAAGAATCACAGAAAAGGAGCACAATTCAATATGCT TTTAGGGGATGGAAGACAGATTTCCTAGGAAAGGAGATACTTAAACTGAATTTTAAATACTTCAGATA TACAAAATCTTTATAAAGAAGAGTAATTAAACCTTATTTAGAGACAGACCACCTAAATAAATGGTACAT ACCCTGTACTGAGTGTGGATTGGAAGACTGAGTATGTTAAAAATGTTAGTATTTCTCAAATTGATAGT GGATTTATTGAAATCCAAATGCAAATTCCTGTAGGTTTTTCTATGGAACCTAACAACCTGATTCAACAA TTTCTGTGGAAGCTTTAAAGAGGCAAGAATAGCCAAAATATACTTTAAAAACAATAAGGTAGGAAGAC TTCTTTAATTCCTTTTTCCACTCGGCAAATTTTTAATGCTCTATGGTAGGCACTGCTCATCCTGGTTAT TACCTTTGTGAATGTGAGATCTGGCTCCCACCCAAAGCTCACATTCAGATCCACTTGTAGTGGTATCT AGGGTTTTGAATAGAACACTTCCTGAAATACAGGTTAAGTACTGGGACTACCAACAAACAAACTTACA ACACTAATTTTATTATCTCATATTTGTATTTACAATTTTTCTTGATCATATTTTTTCATACAAACTTTAATT AGTTTCTATTAATTTCTTTTAACATAGGAAGCTTAGAAATAGACACACTTTGCTTATAATAGATCTTTAA TATTATGTCAGTTGGACTATGGCTTTGTTAGAAAAGGAGAGGAGAATCTACTGCTGAGTGCTGTCCA AAGAGCAGTTACCCAACTGAGCAGAGAGGGAGGATGACCTTGAGGGTCTCACAGGCATGGGTTTTT

[0273] AGGCCCAGCCTGTGGAGCGTCTGAGGGACTTATAAAAGGAAAAGGGACCCAGGTGCAGTGGCTCAT GGCTGTAATCTCAGCACTTTGGGAGGCCAAGGCGGTTGGATCACTTGAGGCCAGGAGTTCGAGACC AGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAATACCAAAATTAGCTGGCTGTGATGGTGC ACGCCTGTAATCCCAGGTACTCGGGAGGTTGAGGCCCAAGAATCACTTGAATCCGGGAGGTGAAGG

[0274] TTGTGGTGAGCTGAGATTGTGCCATTGCATTCTAGCCTGGGCAACAGAGCAAGACTCAGTCTTAAAA

[0275] ACAAACAAACAAGCAAACAGAAAACAACAGAAAGAGGAGATGAATAACAAAATGGCAGGTAATACTA

[0276] AATAATATGGATGAATTTTATATTCTTACATATGGGTAGGTGGAGGGACACCTGCTCTTGTGGCAGAT

[0277] TAGTTGGGAAAGGATACACTTGCTGGAACAATGCCTACCATATTAAATAAATGAAGCTAGACTTCCCC

[0278] ATCTGTTATGCATAAAAATCAATTTCTTGTAGGTTAAAGATTCAATACAAAAGGGGAAACCCTGAAAG

[0279] CTTTTAGAAAAATAAAGGGACATTATTTAAGGCAGAGAAGAATTTCTTAAGACTCAAAAAACTAGCCAT

[0280] AAAAAATGGACAAATTTGACTACATTGAAAATAGAAACTTTTTTCATTAAGCCCCATTAAGACACTCAA

[0281] AAGGCAAGGCAAGGAATAGAAGATACTTATAACACACACTATTAGTTATCTATTGTTGTGTAATTACC

[0282] GAAGACTTAGCAGTTTGAAATAACATTTCTCTCACAGTTCTGTGGGTCAGGAAACTGAGAGTGGCTTA

[0283] ATTGGATGTTTCTGGCTTAGGGCCTTGAGGCTGTAATCAGTCAATGGCTGCAGTCATTTGAAGGCTT

[0284] GACTGCTTTGTGCTCCCTCATGTGGATGTAGCAGGCCTCAGAGCTGGCTTTCTAGAAGGGAGTAAG

[0285] AGAAAACACCCAAGATGGAAACCACAGTATTTTAGTCTTGGAAGTGGCACCCCATCACTTCTGCCAT

[0286] ATTCTTTTTGTTAGAAGCAAGGCAATAACTCCAGCTTACATTCAAGGGGAGTTTGTACAAGGCACCAC

[0287] CAGGAGGGTGAGGATCATTGGGAGCCAGTTTAGAGGCTACCTACTACAACATGTAAAGAATGAACTG

[0288] GTATGAAAAATATACATAAAAAATTCCTATAGATTTCTAAGACAAAGACAGAACACCAAATTGGAAAAA

[0289] GGGCAAAAAATCCTGAGCAGGCATTTGAATTAAAAAAAAATTTAAATGATTAATAAACATATGAAATGA

[0290] CCCTTAATCTAGTTAACAATTAGGGAAATAGAAATTAAAACCACAATGAGAGACCATTTCATATAGATT

[0291] GGCAGAAATGAAAAAATCTGACAATATTAAATGTTGGTGAGGCTATGAAGCAGTCTGAACTGTCTTCC

[0292] ACTGATGGATGGGAATGTAAATTGGGGGGAAAAATCCTTTGGAAAATAATAGGATATCCTATAACCA

[0293] GCAATACCACTCACTCTTAGGCGTTTGCCCTAGACTAATGGTTCTTGAGTATGCATCAAAGTCATCTG

[0294] GAGGGCTTGTTAAACCCAGCTGTTGGGGCTACCCTTAGAGTTTCTGATTAAGTAGGAATTGGGTGGA

[0295] GCCTGATAGTTTGCTTTGCATTTTTAACAAGTTCCTGCCGGGAGTGGGCTGAGGGGTGGGGGGGTG

[0296] GGATGTTGGTGCTGCTTGTCCAGGAATCATACTTTGAGAGTCAGCCATTGCTTTAGACATAGAGAAA

[0297] TGTGTGAATATATGAAGTAGGAAGCATATATATAAGATTGCTCATAACAGTATTATTCATATTAACCCC

[0298] AAGATAGAAAAAAAGTTCAAGTATCCTCAGTAGTGCAGTAGATATCATTGTGTGTTTACTTATGGAAC

[0299] AAAAAACTAGTTCAAATAGCTAAGGAAAAAAACCACACTACAAACAGCTCCTGCCTGCATCAATATGT

[0300] ATGAATCTCACAAATACATTAGTCATACCTTAGAACCAAGTCACAAAAGATTAAGTGCAACATGATTCT

[0301] ATTCGTAAACAGTTTAAAAACAAATGCAGTTAACTGTATTGTTTAGGAATACAAATATAGGTACTAGAA

[0302] TTATAAGTAGAGATACTAGAATTATAAGAAAAATCAAGGGAATAATGATGATAAAAGTGAGTGATAGT

[0303] GACTACCTCAGGGAGGAGAGAAAGTGGATGTGATTAAGGACAAATGGGAGACTTTTAAGATAATTGG

[0304] CAATGCTATTTCTTACCTTGGGTTGTGGGGTTTGCTTTACAGTTATGCTTTAATGGAACGATGTTTTG

[0305] CAAACTTCTCTACATAGCTTTATAATAAAGGGAAAATTTATCTCATTTAATTTTCATCTCTGATTACTAG

[0306] TGAGGTTGAGTATGTTTTCATATGTTAGCCTTTGGGTTTTTTCTTAAATTGTTTATAGACATGCCATTT

[0307] GTAGATTATGCTATTTGTTTTTAGAACTTATTTTTAGGTATTCTGTTATGGATAGTCTTCTTTATCCATC

[0308] ATATGTCAAATATTTCCTTCTAGTCCTTTTTTATTTGTATTTTTATTTATTTTTATTTCTTTTTTAAGAGGC

[0309] AGGCCTCCCACTCTATTGAGGCCTAGGCTATGGATAGTCTTCTTTATCCATCATGTCAAATATTTCCT

[0310] TCTAGTCCTTTTTTATTTGTATTTTTATTTATTTATTTTTTTAAGAGGCAAGCCTCCCACTCTTTTGAGA

[0311] CCCAGGCTGGAGTGCAGTAGTGTGATCATAGCTCACTGCAGCCTCCTGGGCTCAAGCAGTCTTCTA GCCTCAGCCTAAGTAACTGGGACAAATGCACACCACTGTGCCCAACTAATTTGAAAAAGAAAAAATTT GTAGAGATGGAGTCTTGCTGTGTTGCCCAGGCTGGTCTCGACTCCTGGCTTCAAGTGATTCTCCCAC CTTGGCCTCCCAAAGTGCTGGGATTACAGACGTGAGACACTGTTCCTGCCCTAGCCTTTCCTTATAA AGACATATGTTGTTGTTACTGTTTATGTGGTCAGATTTAGCAGTCTTTTCATTTATTTATTTATTTTGAT TTTGATTTTGATTTTTTTAAGAAATCTTTCCTGGCTGGGCGCGGTGGCTCACACCTGTCATCCCAGCA CTTTGGGAGGCCAAGGTGAGCAGATCATGAGGTCAAGAGATTGAGACCATCCTGGCATGGATGAAA CATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGGACGTGGTGGTGTGTGCCTGTAGT CCCAGATACTCGATAGCCTGAGGCAGGAGAATTGCTTGAACCCGGGAGGCAGAGGTTGCATGAGCT GAGATTGTGCCACTGCACTCCAGCCTGGCGACAGAGCAAGACTCTGTCTCAAAAAAAAAAAAAAAAA AAAAGAAAAAAGAAATCTTTCCTATCCAGAGTTAAAAGCATATTCTCTATATTGTCTTCTGATAAATTG AAAATTTTAAAAATTTTGTTTAGGTATTTAAGCAGTCTAGTATTTGTTATATGAAGATGTCTTGGGGGA TGTTATTTTCCCAACACCATTTGTACATATGTGCACAGTCTTTTTCTCACTTATTTGTAAAGCAACCTC TCATTTCTACCAGATTCCCATGGACCGATTTCTGGGCTACTTCTTAACCTGTTTGTCTATAACCTGTTT GTCCACATTACTACTTTATATCTTTGGTTTTGGTAATGCCAGTCTCTTCTCTTTGTTTATTTGCGGCAA ACATATGCTCATTCACTCTTCCACGTGACCATTAGAAGAATTAGATTGTCAATGTCCTCTAAGTCTAG GTATTTGGTTAAAAAAAAAAAAAAAGAATTAGGTTGTCAAATTCTGTAAAAAGTACTATTGGGATTTTC ATTGTGATTGCATTAAGTTTATATGTTAATGTAGGGACATATATATTAGAGATTTATTATGATACTGAGT TTTCCAATTCATGAACATGGTTTTTATCTTCATTTGTTTATAGGTCTCTTCCCCCCCCACCCCTTTTTTT TTTTTTTTTTTTGAGATGGAGTCTCGCTCTGTCACCCAGGCTGGAGCACAGTGGCACAATCTTGGCTT ATTGCAGTCTCTGCCTCCCATGTTCAAGCAGTTCTCCTCTCAGCCTTCCGAGTAGCTGGGACTATAG GTGCACACCACCATGCCCGGCTTATTTTTGTATTTTCAGTAGAGACGGAGTTTCACCATATTGGTCAG GCTGGTCTCGAACTCCTGACCTCAGGTGATCCACCTGCCTCGGCCTCCCAAAGTGCTGGGATTACA G ACGTG AG CCACCG CG CCTG GG CCATGTGTTTCTATTTTTAGTAG AG ACAGG ATTTCACC ATGTTG G

[0312] CCAGGCTGGTCTCAAACTCTTGACCTCAGGTGATCCACCCGCCTCAGCCTCCCAACGTGTTGGGAT TACAGGTGTGAGCCACTACTCCCAGCTCTGTTTTTTTTTCCTTAAAAGGTTTATAGTTTTCTACATAAT GTTTTCATCCTTTTGGATGTGGAGGATTGGTATTATTTGCGAGAATCTTTTTGTGCTGTTGTGAATGA GATGTTTAGAAAAAAATATATTTTTTTACTGGATATTCATATACAGAAGAATGAAACTAGACCCCCACC TCTCACCCTATACAAAAATCAACTCAAAATGGATCAAAGACCTACCTGTAAGACCCAAAACTACAAGG TGAAACCACAGTGTGGTATCATCTGGCCCCAGGTAGGATGGCTGCTATAAAACTGTAGAAGACTTGG GAAATGCAAATCAAAACCACAGTGAGGTATTGTCTCATCCCAGTTAGGGTGGCTGTTATAAAAAAGA CAAAAAATTAAAAATGCTGGTGAAGATACAGAGGAAAGAGAACTCTTGGACGCTCTTGGTGGGAATG TAAACTAGTACAGACACTGTATCAGTATGGAGGTTCCTGTGATCTAGCAATCCCACTACTGGCCGTTT ACCCAAAGGAAGGGAAGTCAGTACGTCGAAGAGACATTTGCATCCCCATGTTTACTGCAGCACACTA TTCACAGTAGCCAAGATATGGAATCAGTTCAACAACAGAAGATTGGGTAAAGACAATGTGGTTGTATA GCATCCGATGGAATGCTATTCAGCCGTAAAAAGGAAAAATCCTGTCATTTGCAGCAACATGATTGGA ACTGGAGGACATCACGTTAAGTGAAATAAGCCAGCAAAAGAAAGTTAAACCCTGCATGTTCTCACTC TTATG TG G AAG CTAAAAAG AGTTG ATTTC ATAG AAG TAAAAAG TATAAC AG AG G ATACTCG G G CTG G GAATAGTAGGGGTAGAGTGGAAGCTCTGGGGAGATTTATTCATGGATACAAAATTACAGCTAGATAG GAGGAATAAGTTCTAGTGTTCTGTAGTAGTATAGGGTGACTATAGTTAATAATATATAGTTTCATATAG CTAGGAGGAGGATATTGAATATTCCCAACACAAAGAAATGACGAATGTTTCTCCTGTCTTTAGTGAGA ATGCTTCTGTTATGCTTGGTGACTTACAGACTTTTTATAGATACCCTATATGAAGTTTAAGAATGTTTC TTCCATTTCTAGTTTGCTGACAGTTGGGCATTTTTAAAAATCCTAAATGGTTGTTGAATTTTGTTAGAT TTTTTTCGTACATTTATTGAGGTGATCATGTTTTTTTCCTACATTGATCTATTTAGGTAAGTAATTGTAT TGGTAGACTTCCTAGTTTTGAGTAAGCAACTCTTGTGTCACTGGATACATTTTATTGTATATTCTTTTA ATTGATTGTTGAATTAGGTTTGCCTAATTCAGGTTTTTATTTAGGGATTTTACGACTGTGTTTACAAGT GAGCTCAGTCTATACCTCTCTGAGCTGTTCCATGGTTTTGGTATCAAGAGCTGATTCGTTTTCTAGAG TTTTCTGTGATTTTGGCCAGTTTTTATATCAGACCAAAGAAAATGTTTCTCGAAAGTAAGTTCATTAGG CTTTAAGTAACCACTGGGCCCATTCTTTGACTTTCAACTTTTCTGAGTGAGTTTTAGATGTGGATGTTA TATACAGCATTTGTTCAGGGCTTTGGTTTGTGAGCTGAGTTTCTTTTTTTATTTTTTTAATAGATGAGC TTATCTCATTTATATTTTGTTGATAAGGCAGTTCTTCCACATTATTAATTATATTTTTCTTTGGGGGCTT TGTCTCTTATGGGTATGTGTGTGTTTCCCATCTAATAGTTTTTGATGATTTTTTATAAATCTTATTCTCT TACTACCTTCATAGATTTAATATCTGTAAGCCTCCATTTCTTGATTTGTGAAAATAATCAGGACTATTTT AACTCCTTGCTAATAAAGGTAAGAAAATCAGTACACTTATACCTCCCTTTCCCCAGCTACCATTAAAAA AATTTTTTTCCATCTCTTCATATGAGATATAAACCTTGTCATTGAAAAAAATGCATTTATTTTTTACTTTA TCCTTAAGTCTCAGAGTTACATGTTTGAATGGGATTAATATTCACCTTTAATTCTTTAAAACCATGACT TCTTGATTTCTAATTCTGTTTTATTTATCTTTTCATCAGCTTGATTTTCCTATCAAGTAGTTCTGTTTTTT CTGCCAAGAATGGCTTCCTTTTTTCTTCTTCAGCCATTTCTTTCTGTTTCCACCGTGGCCTTCATTTCT GAAGTGGTCTTTTTATTACCTTCCATTTCTTTCTTGAACCCTGCTAACTCACTTTTCATTTCCTATTTCT TTTTTTTGAGACAGGGTCTGGGTCTCTCACTCAGGCTGGAGTGCAGTGTTGTGATCTTGGCTCACTG

[0313] CAACCTCTG CCTCCTGG G CTCAAG CCATCCTCCC ATCTCG GCCTCTC AATTAG CTG GG ACTACAG AC ATGTGCTACCACACCTGGCTAATTTTTTGCATTTTTTTGTAGAGGCAGGGTTTCATCATGTTGACCAG GCTGGTCTCAAATTCGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGAGTGAGCCACTGCCTCCTG CCTCATCTCCCATTTCATCTGTTCTTCAATTTTGTTTTTTCAGTCATTTTTTTCCCCTAAAATGCATTTG ATAGTGATAGATGGGGATATATCAGAGACTTCTTTTGTTTCCTTGACTAACTTCTGGTGTTTATCTGTC TTTGCCTATTATGTTTCTTCTCTCATCCCCCACTCCCTGTTTTATTGGTGGTGTGGCGGGTGGGGTTG TTAACGTTTCTCCTCATAGACCCTTTGCTGGATTGTTTCTTTTTATTACTCATCCTTGTTGTCTTTGAGT AGAGTACTTCTATTTGAGCCTGCTCTTTGCTTAAGAATGTTATGGGGGGCTGGGCACAGTGGCTCAC ACCTGTAATCACAGCACTTTGGGAGGCCGAGGTGGGCAGATCACGAGGTCAAGAGATCGAGACCAT CCTGGCTAACATGGTGAAACCCCGTCTCCACTGAAAATACAAAAAATTAGCCAGGCATGGTGGCGG GCGCCTGTAGCCCTAGCTACTCAGGAGGCTGAGGCAGGAGAATGGTGTGAACCCTGGGGGCAGAG CTTGCAGTGAGCTGAGATCGCGCCACTGCACTCCAGCCTGGGTGACAGAGCAAGACTCTGTCTCAA AAAAAAAAAAAAAG AATGTTATG G G G AAC AG C AG G G AG AATAAG CCTAAG C AG G C ATAACTTTTTTCT CAGACATCTTGTCTCAGAAAGCTCGTTCACCAAATCTGTTGTGTTCTCTACCCTGGGAATACATCACT CCTCCATTTTTAATGTCTTTTTTCCCCTTCCTGCCATTTTGGGCCAAGCCAATCATTCAGTCAGGATG AAGACTCCATCCAGGCAGGAGATGGGTGAGGCTGATAGTGAAGTTGGACATCAAATAGATTCCTGTT CGATGATTTGATTTTTAATTTGTTCTGCTCAGCTGCCTTTAGCTTTTAACCTTTTATATCTTATGTTCAA TAGTTATTCTCACAAAGGAACTGGTTCCCAACATAAATTTAAAATTAAAAGTGATCAGTTCTCTCCTCT AGCAAACTGTAACTGCTTTTATTTTATGTGACTTGATCTGATGTATTGTTTTGTTCCCTGGATCATTTA GGGGTGGGGAAGTAAAGACAGGGAGGTCTGTGTTTCACTTTAAAAACAAAATCTAAACCAGATAAAA

[0314] ACTCGTAAAATGTCATATTTCAGGTCCTCTGTGATCTTGCCCTTTCCTACCTCTCTACCCCTGCCCAC

[0315] GTCTATCAGCCATCCTTGCTGTGTACTAAATGCTCTAGCACAGTATTTCCTAAAGTTTATATTGTGGAT

[0316] ACTGAATATTCAAAGTGTTCTCCCAAAGATAGGTTCCATAGTTTACAATTTTGGGAAACTTTAAATGTT

[0317] CCTCCTTGTCTAACCTGTTGAGTTTCTAAGCTCAAATGAGGGGGGATACTGTGTTATCTAAATCTTAT

[0318] TTGATTTCTGTATTTTACATATTAAGGGATTCATCTAAAAAGTATCTGAATTGATTTGGCAAGCAGGTG

[0319] ATACCCTGTACTATATTATATAGCTCCCCTTTTGGGATTTCATAATTGGATATTAGCATAGTAATGGTT

[0320] GAGAAGAACTGTAGTAAAGAAGCTTACCTTTGTTGATTTATTTTTTTTTTTTGACACAGATTCTCGCTC

[0321] TCTCACCCAGGCTGGAGTGCAGTGGCACAATCTCGGCTCACTGCAACCTCCACCTCCTGGGCTCAA

[0322] GCAATTCTGTTACCCTTCCAAGTAGTTGGGACTACAGGTGTGTGCCACCACACCTGGCTAATTGTTTT

[0323] TAAATATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAAA

[0324] TGATCCACCTGCCTCGGCCTCCGAAAGTGCTGGGATTACAGCATTAGCCACTGCACCTGGCCTTAC

[0325] CTTTGTCTAAATTAGAATTGTATAAACTTCCTTGACTATGGAACATTGCTTGTGTGTAGTATATGCTAA

[0326] TATTCTTTGAAACATTTTAGGGAAATGCTGTTTAATACCAATCAAATCCTTGCATTTTTTCAGGGTTGT

[0327] TTCCTGTTGTTTCTGGCCCTTTGTCCTAGAATGCTCTCTTCCTTCATTTTCTCCATACCACCCAATTTT

[0328] TTTTTTCAATGGTTTCTGAGGTGATACTTACCCTGCTGGGAGGCATTTGGAAATATTTTGATTGTCAT

[0329] GCCTGGAGGATGCTATTTGGGATTTAATGCCCTCAAATCGAGGAACACAATGCACTAAAAGTCCTAC

[0330] ACAGCAAAGAATTGCCCCACCCAAAATGCCACTTCTACAGTGGCCCTCCATATCTGCAAGTTCTGCA

[0331] TCCTAGGATTCACCCAACTGCAGATCAAAAGTATTAGGAAAACAGTAAAAAGTAATACAATAATACAA

[0332] ATACAAGATAATACAGTATAACAACTATTTATATAACATTTACATTATATTAGTCATTATAAGTAATCTA

[0333] AAGATGATTTAAAGTATATGGAAAGTAAGTTATATGCAAATACCCTCCCTTTTTATATAAGAGACTTCC

[0334] GCATCCAAGGATCATGGTGTTGTAGGGTAGAGTCCTGGAACCAATCCCTTGTGGATATGGAGGAAT

[0335] GACTGTATACTCCTTTGGAGAACACTGAACTCAGCAACTTTTACTCATCCTTTAGAATTTAGTTCTGGT

[0336] TATCTTTTCCAAAAGCTTTCTCTAAGTACTTTTGTTTTCCCCTCTACCCCACACCCTCTCATTTTCTCT

[0337] GCGTGGTACTCTCAGAGTATTTTAGGCACATCTTGATTATTTGAAGTAACCACTTTGTAGTATAGGAG

[0338] CCTATAACTGTATACCTCTACTGTACTGTGAGTTCAAATCTTTGAGGGCAAAGACATTTTGTATCCTTG

[0339] GTATATGATATATAATTAGTCTTTTAAAAAGTGCATGTTACATGAATACATTAATAAATAAGTTGTACTT

[0340] TTACTTTAAATCAGAATTGTGGTATGACTCTTAAACTGTTGCTTAGACTGCATTAATAATCTTGTGCAA

[0341] TTGTG G AAAATAATCTCATTTTACTCTC ATAATAG AAAATTAAAATATG CTTCCTTTTG CTCAG ATATG G

[0342] GTGACAGCTGTTAGAGTAGTGTTTTATTTGGGTTTTGACCTTGCCTGTACATCAGAAGCACCTGGAG

[0343] AACTTCAGAAGGTACAGATGCCTGGGGCCCTGCACCAGAGGTTCTGGTTTTTGAGGGTGAGGCCTT

[0344] GGTATCTGGATTTTTAAAAGCTTCCAAGGTGATTTTTAATCTGAAGTTAAGATTGAAAAGTCATTTAGT

[0345] GAGACACTGATATGTAGCATTTTGGGAAGTCAGTAAACTTAAGAGTGAGAAGTTACTAAATCATTGAA

[0346] GAACAGTGAAAGGAGTAGGGAGTTTTAGCTTAGAAAAAAAAAATCTAGATGGAGTATGTGAGTTCTCT

[0347] GAGGGCTATAGGAATTTGTCCGTCTTGCTCACCACTGTATCCTCAACTCCTAGCATGAGCCTGAGCA

[0348] CATACAGGGATTTGGTAGATATTTATTGGCTGACAGAAGAATATGTATCATTAGGTGTTTAAAAGATA

[0349] GTCATTGTAGAACCACAGAGATTATCCCCAAAAAAGTTTTATAGTAATAATGTGCCACTTAATTTTATG

[0350] ATTAAAAATAATGAACTGGATATTTAATTCATTTATCATTTCAGTTTATTATTTACTTTGTGCCAGTCAC

[0351] TGAGGATTCCATTTGATTCTCTGGTCAAATCTATGAAGTTTGTATCATTCAAATAATAGGGCTGTGTCA AGAAACTGACACTTGGGGGTTAAGTAATTTGCCTAAGGTTACAAAGCTAAGTGACAAGAGCTGGAAT TCTTAAAGTCTGTACTCTTAACTGCTATGCCTTACCATAAGTCTTCACCACAACCCTAAGAGTTAGATA TGGTTTAGAAAGGTTATGCAGCTTGCCTAAGGGCACATTGCTTGAGTGGAAGATTTGGGACTTGGAC CCAGACATTGTGACACTAGAGTCCATGCTGTTAACTGCCATGCTATTGGAACCCCCAACCCCCTCGC TTCCTATTGTATAATGTAC AACCATCTGTTTTC ATG AG ATTATTAACCACAGTG G ACAG CTTGTGTTG C TCTCCTTATACCTTTTGGCATCCTCACTGACTTTTGACTGATGGGTTGAATTTGGATTATTGTCTTGAA TCTCCTTAGTACCCTGGGCTGTGGTAGTCCTAGAAAATAAAACATTTCTTTACTAGGTTCTTTTTCTTC ATTTCTTTTTCCTTTTAGTTAGGATTTTAAATTAGAATTTTAATAAACTTGCTTGCATTAATACACTGATA TCTGTTAGCTTCTGTTATTTTAAGTCGGTAGTCTCCAGACTTAAAAATTTTGTTCTCTATCATAAAAAAA ATTTGAGCACATTACCCCTAGTAGATATCTGTTTTATTTATGCTATATGTGTACTACTGAAGAAAATGG TAATATTTTAAAAAATATGAACTTGTTAGCATGAATTTTTTTAAAGCTAAGCTAAAAATGAAGTGAGTTT AAAATTATGAAGGGTTTTTGCTGATGTTTCAAGTTTAGCTAATGTTTCAAGTTACAACATACCATTAGG CCAAGGTTCGTTATTATAATAGTGTGTACAAATTCATATTTTAAGTAGCCTGGATAATTTTTTTAAAATA GCTAGTTTCTTGTCAGAAATTAAGTAACCTGGATAATTTTTTAAAAGCCAGTTTCTTGTCAGAGATTAT TAGATTAGGGTTTCTCAACATTGGCGCTGTTGATGTTTTGAAATGGATGTAATTCTTGCTTGTAGGGT TATGATCTGCAGTTGAGTGAATCCTACGATGTAGAACTTGCAGATATGGAGGGCCACTGTAAAAGTG GCATTTTGGGTGGGGCAATAATACTATGTATTGTAGGATGTTTAGCAGCTTCCGTGGCCTCTGCTCA CAAGATGCCAGTAGTACCCCCAAGTAGAAACATCAAAAATGCCGGGAGACATTTCCAAATGTCTTGA GGGGCAAAATTGCTTCTGGTTAAGGACCACTAGATTAGAATTTTTTTTTTTTTTAAGACGGAGTTTTGC TTTTGTTGCCCAGGCTATAGTGCAATGGCGCAATCTCGGCCCACTGCAACCTCCACCTCCCAGATTC AAGCGATTCTCTTGCCACAGCCTCCTGAGTAGCTAGGATTACAGGTGCCCGCCACCGCACCCTTCTA ATTTTGTACTTTTAGTAGAGACAGGGTTTCTCCACGTTGGTCAGGCTGGTCTCGAACTCCCAACCTCA GGTGATCTGCCCGCCTCAGCTTCCAGAGTGCTGGTATTACAGGTGTGAGCCACTGCACCCGCGCTA GATCATTGTTTTTATCCTGTATTATGGATGACAAGCAGCTTGTAGTAGAGTAGGGAAAGTGTTAACTT TGATTTTTTCCCCTCTAGCAGCAATAATGTTTTCTTCAGTATGAAGTTTGAGATCTGTTTGTAGGAATT AATTTTAAGTCACTTGTCCATTCTATAAGGTTTAGTTAAAACTTGGTAACATAATCCATACGTTTACTTA AATCAATATATGTGAGTCATAGTATGTCACAATGAGATAAATGCAAGAGGAGAGCCACTGTCAAGTGT TCTGCAGTATGGAATGCCCAGCCTTCAGCAGACCTCTTGACTATATGTGTCACATCTCTGATACTAAC CCTAAGTTAGGGTGCCTGTGTAAATATTAAATGCTGAGGCCAGGCACAGTGGCTTACGCCTGTGATC CCAGCACTTTGGAAGGCCGAGGTAGACGGATCACAAGGTCAGGAGATCAAGACCATCCTGACTAAA CACAGTGAAACCCCGTCTCTATTAAAAACGCAAAAAATTAGCCAGGCATGGTGGCATGTGCCTGTAG TCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCACTTGAACCCAGGAGGTTGCAGTGAGCTGAAA TCATG CC ACTG CACTCTAG CCTG G ATG AC AAAGCG AG ACTCTGTCTC AAAAAAAAAAAAAAAATTAAA CGAGCATGGTGGCATGCATCTGTAGTCCCAGCTACTTGGGTGGCCAAGGTGGGAGGATTGCTTGAA CCCAAAAGTTTGAGCCTGCGGTGAGCTGTGATCACACTACTGCACTCCAGCCTGGGCACAGAGTGA AACCCTACATCTCAAAAAATAAATATTAAATGCTGACTTTTTCTAAGTTTCTAGATGAACACATTAACTA AATAATGTAGCCTACCTATATCCCCAAAAAAGAGTCTTCCTATGGGCCCTCAGGTGTATGTGCATACC TATTTTGTAAACCACTTGTTTGACCATCACATTGTAACTTATTGTTCAATTTGTGTCACTGCAGCCATA

[0352] TTACCCAAAAGGGAAAAGTAATTTTAGCTCTCTGAACTGACCTCCACCTAACCAACTCATCAGGTTAA CTGATGTTCTCCATTTCAAAAAATATTTGCGGTCAGATTAGGTGTGAATCATATTTAAAGGAAGATTGT TGGTCCTATATCAAAGATTAGAGAATGAATGTTCATTTTACAGTTTTAAGTTAAAATGTTTAAGGACAG TGTTTACCATTGCACATGATTCCCTGATTTAACTGACCTTTTCAGTTAACTAGCCACTAGACATAATTA CATTGACTATAGGGGCTTCTTTTGTGCCACACCAGTGTTGGAATTGTGTTGATTTACTTGTGGAGTTG GAACTACAGTTTCTCTCAGCAGCCTGCTTATCTGGTTGTTTAAACTTGTAGCTGAATTATTATACAAAG TTTTCAAACTTTCTGTTTTG G AATGGTCAGTTACTC AAAACTGTG G CTTCCTCCTTG CTACCTTAC AG G GTAGTTGTGAGAGTATTCCTCAACAATAGTTCAGACTCTCATTACTTCTTGTCTATAATTGTAGCATGC TTTTAATGG G ATTCCCTG CCTCCAGTACCTCTCTG G CTTGTTG GTTAACATAAACATTATTG CCAG AT TAAACATCCTAAAGTATAATGTGTAATCAGATCAAAAGCCATTTATAACAATAAAAACTACATTAAAAA ATTACTTATGTCCTGGGCTTAGATGTGGTCTCTGCAATCAGATGTTCATTAAACAAATTATTTAAAAAA TACATAC ATAC AC ACACACG CAAATTCTG AATTGTG ATATGTG CCAAAAG AAAAAATG GG GG GTG AT GTGAGAGCTCAGTGAGGATCAAATATAGATTGGGAAGAAGGGTGATGAGGAAAGACTTCTTTGAGAA AGTGAGATTTAAACTATCTGAAGAAGCTGTGCTTAGTTTAGAAAAGTGCTAGGCAAAGAGTGTTCCAG GAAGAAGGAATAGCATGTGTGAAGGCTCTGCTCTGCTGCTGAAATTGTGGTTCAGTTTATTGAGTAT GGCATAGAATGAATAGTGCCTGATGAGGCAGGAGGTAGGCTGGGATGAGATCTTTTCAGATCTTGC ACTCTGTACTAGGAAGTTTAGGTTGTATTCTGAGTTACTGGGGAGCCATTAAAGGGTTTAAGGAAGG GGAGTGTTGTGAATCAGTTATGTGTTTTGCAGATTCTACTCTGACTACAGAATGGATGAGAGCAGAAT GGGAGTTAGAGCAAAAGAAATGAGGAAACCAGTTAGAATGCCTTTGTAAGTAGTAGGTCAGAGAGAA AGGATGATAATTTTGACTAGAGTCATGACAGTAAACAAGGTAACACATGAAGTGATTATGTCATAAAC TATTACCATTACCCTGTGAAGGAAGTATGAGCAGAATAAGATTTAGAATAAACTTATTCCAAGCCCAT CTAATAAAGGGTGGTGTGAGGAACTGAAACAATGGGTGTTTCAGGACATTCGGTCCTTGTCTCTAAA ATAAAATCCAAACTCTGTTGAAGATTTTTCAGCCTACTCTTATTATCTTTGTCTTCTCCTAAACTCTTAC TCACCTATGCTATAATCATACCAAACTATTACAGTGAGTATCATGAACATTTCCTGTACCTTGATGCCA CTGATGATTGTTTACTATGGCTGGAATACTCTTACTCCCACATACACTTAACAAAACCCTACTCATTGT TTAGGATCCAGATCAAATATGAATGAAGCCTTCCAAATTTGCCTCCAGATTGATATTGCCCATTTATCT TCTTTTAACCATAGTAGTTCATATTACTATCACATTATAGTATATTATTCAACAGATGTCTATGTAATTG ATTATGTGCCAGGTACTATGTGTAGACATTATGGATATATCCACATACAAAAATAGACACAGTTGCCG CATTTGTGGAAACTACATTGTAACACAGACCTTGAACAAAATCTGGGCACAAATATGTAACTAAATGT TAATAAGAGGTATGAAGGAATACCTGCAGGTTTCTGAAACCCTAATAAGGCCCTTGAGGTCAAAATTA TTTTCATAATCCTACTAAGATACTATTTGCCTTTTCATTCTCGTTCTTGTGAGTATGTAGTAGTTATAGG ATGTATGATATTCCAACAAATTGAATACAGAAGGTGGGAGAATCCAGATATCTTTTGTTAAGGCAGAC ATTAAAGAAATTGGCAAAAAAAAAATTTTTTTTTTTAAAGCCACTTTGGGGCCAGGTGCGGTGGCTCA CACCTGTAATCCCAGCACTCTGGGAGTCTGAGGTGGGCAGATCACTTGAGGTCAGGAGTTCAAGAC CAGCCTGGCCAACATGATGAAACCTCGTCTTTACCAAAAATATGGTAGCTGGGTGTGGTAGCACATG CCTGTAATCCGTCCCTGTAATCGGAAGGCTGAGAGGCGGGAGAATCGCTTGAACCTGGGAGGCCAA GGTTGAAGTGAGCTGAGATCGTGCCATTGCACTCCAGCCTGGGCGACAAGAGCAAGACTGTGTCTC

[0353] AAAATAAATGAATAAATAAACAAACAAATAAATAAATAAATAAAAATGAATAAGACACTTTGCCCTCTC ATTGTTTTTTGTTGTTTTGGAAAATGTGGTTATTTTTTTCATTAAAAAATAGATCACTTTTGTTAATTAGT TTTTTTGTCATTTTAAAATGAATTTTAAACATTTCTTGGTTATAATTTTTAATGTGGTAAATACTGATAGC GATAAACTACATAGATAAAAGCTTTCTAGGGTCCTCCATAATTTTTAAGAGTATAAAGGGGCCAAGTG TGGTGGCTAACACCTGTAATCCCAACACTTTGGGAGGCCAATGCAGGAAGATCCAACATAGCAAGAC CCTATCTCTACAAAAAAATTTAAAAATTAGCCAGACGTGATGGTGTGTGCCTGTAGTCCTAGTTACTT GGGAGGCTGAGGTGAGAGGATCACTTGAGCCCAGAGTTTGAGATTGTGGGGAGCTGTGGTCATGC ACTACATTCCTGCCTGGGCTACAGAGTGAGACCCTATCTCAAAAAAAAAAATTATATTTTTATACACAC ACACACACACACACACACACACACACACACACACACACACATATCTTATATATATATAAGAGATCCTG AAACCAAAATCAGAGTCCCTGTAATGGGGAGCTGATTTAAATTGGGGGCTTCTGGAGAAGTAAAAGA TATCTTATGTCTCTGTTAAACACTTATGTTCTTCTAGAAATTAGGAGTGTGGTTTTCTCCGTATTTCCA AAAACTGCAAGTCTTTTTATATAACGAGTGTGTTGGTTGAATCTAATTTTAAAAAAAATTTTTTTAATTT AAAAATTTTTTAATTTTTAAAAATATGGAGTGCTTCATGAATTTGCATGCCATTCTTAGGCAAGGGCCA TGCCTATCTTCTCTGTATTATTCCAATTTTAGTATATGTGCTGCTGAAGCAAGCACCAAATTTTGTTAT

[0354] CAAAGTCTACTGTAGATGGCCGTTCTTTCTTTGATTTGTGGTTTGGTTGAAACCTTTGTTGGAAATAC CATCTTATTTCTTATTACTGTAGGAAATAGATCTGGATTCAAATTCCTCTTGGTATGAAGCTGGGAAGA TTACTTAACCTGCTAAACCTTACCATTATTTATCTGTAACATGGAATACATATTATCTTACTGTGGTGTA ATGATTTAATGAACTAATGTATGTGACCTGATTCATAAGTGACCAGAACAGAGACAATCCATAAAATG GTAATTCTTTTTATTTTATATACACAGCACATACATACTGGGGTTAGTTTCAGTTAGTGAGCAGAGAG GTCTGTGGATAAATCAGGATATAACAATCATCATTCAAGGATATATTCACCATTCAAACAGTTTATCAG AAGGCAGAAAGCCAGAATGATCTATTGTGTATGGTTATTCATCTTTAGAAAAAGGAACAGAAAGTGTG GGCTTAGAATATTTTAAATAAGTAGCTCTATGTTACAATGTAGATGATTTAGGGATGGGGTAGAGTTT TATGTGTCTGGCACTACAGCAGTGCCTCACATTTACTAAATGTTTGAATAATATTAATTAACTAGAGAT TCTTGAAAACACATTTTTAGAAGCCTTGAAAAAGTTATATACGACAGATTAAAGGCCAAGCCTGAGAA AGCTTACATGGCTAACTGGAAAAATAAATAAAGGTACCATAGAGGAAAAACAAAATTGCCCTGTGGG

[0355] GAGAACATGTGGTGTCATATGGTGTGACTAAATAGGATCCAGTAAGATAAGACAAGGTAGAGCATCT TGGGAGTGATTCCATGTTTCAAGGTTAAAATGTTAACTACATTAAAGGTAGTAAACCAGTGAAAGAAT

[0356] CCTCAAGATCCCAGTGCAGAATGTTTGCCAAGAGATAAGAAGATCAACTGTTTTGGTATTCATAGCAG AAAGCCATAGGAAAATTATCTTTTTGATATTCTTTTTTGAAGAAGATAGGTCCTTTATTTATTTATTTAT TTATTTATTTATTTATTTACTTTATTTTATTTTATTTTTTGAGATGGAGTTTCGCTCTTGTTCCCCAGCTG GAGTGCAGTGGTGCAATCTTGGCTCACTGCAGCCTCCGCCTCCCAGGTTCAAGCAATTCTTCTGCCT CAGCCTCCTGAGTAGCTGGGATTGCAGGCATGCACCACCATGCCCAGTTAATTTTTATTTTTAGTAGA G ACG GG GTTTCTTCTCC ATGTTG GTC AG GTTG GTCTCCAACTCCTG ACCTC AG GTG ATCCACCCG CC TCGGCCTCCCAAAGTGCTGGCATTACAAGCGTGAGTCACCGCGCCCAGCCAAAGATAGGTCCTTTT TTAAGACAGATACTTAGGGCTGGGTGCTGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCG AGGCAGGTAGATCACCTAAGGTCTGGTGTTCAAGACCAGCCTGACCAATATGGTGAAACCCAATCTC TACTAAAAATACAAAAATTAGCTGGGTGTGGTGGCGTGCGCCTGTAGTCCCAGCTACTTGGGTGGCA ATTCAAGGAGAATTGCTTGAACCCCCGGGAGGCAGAGGTTGCAGTGAGCCGAGATCGTGCCTCTGC

[0357] CCTCCAACCTGGGTGACAGAGCAAGACTCCATCTCACAAAAAAAAAAAAAAAAAAAAGATACTTTGAT AAAGAAATAATAGTTATTTCTCATTTTATTTCTCATTTGAGATGAACTCAAAGTTGGCTAAAGTGACAC ACAGTTTTGGACCTATAACTTGCTTACATTTTAAATATTAGGTTGGTGCAAAAGTAATTGTGGTTTTTG CCACCCAATAGAAAGGATTGTAGACATTTTTTTATTTGACAACTGTAAAGCATTGCAGGAATTATATGT GGAATTATAGGCTTACTTTGTTTTATTGTGTTTCATTTTATTGTACTACACAGATAATGTGGTTTTTTTT ACAAATTG AAG GTTG GTG G CAGCCTTAC ATCAAG CAAGTCTGTTAGCG CCATTTTTCCAACAGCACA TGCTCACTTTGTGTCTCTGTGTCACATTTTAGTAATTCTTGCAATATTTCAAACTTTGTCTGTTTTGGT GTTCTGTGATCTTGCATGTTACTATTGTAATTGTTTTGGGGTGCCACAAACCACACCCATAATAAGGC AGTGAACTTAATCAGTAAATATTGTGTGTGATCTAACTGCTCCACTGACTGGCTGTTCCCCCAACTCT TCTCCAGCCTCCGCATGCCCTGAGACACAACAATATTGAAGTTAGGCCAATTAATAACTCTACAATGG CCTCTAAGTATTCAAGTGAAACCAAGAGTCACATGTCTCTTGAAATCAAAAGCTAGAAATGATTAAGC TTAGTGAAGAAGGCATGTCAAAAAGCTATGCCTTTTGTGCCAGACAGCTAGGTTGTGAATGTAAAGG CAAAATTTTGGAAGGAAACTACAAGTGCTACTCCAGTGAATACACGAATGATAAGAAAGCAAAACAG GCTCATGCCTGTAATCCCAGCACTTTTAAGAGGCCAAGGTGGGAGGATCACTTGAGGCTAGGAGTT CGAGACCAGCCTGGCCATCATAGTGAGACGTCGTCTCCATTCATTTTTAAAAAGCAGGCAAGCAAAA CAGCCTAATTGCTGAGATGGAGAAAGTTTTAGTGATCTGGATAGAATATCAAACCAGCCACAACATTT CCTTAAGTCAATGACAGGCTTTAAAGCTTCAAAGGACAGGCTGACTCTTACTAGAGGCTAATGCAGC TGGTGACTTTAAGTTGAAGTCAGTGCTCATTTATCATTCCAAAAATCCTAGGGCCCTTTGGAATTCTG CAAAATTTACTCTGTCTGTGCTCTGTAAATGGAACAATGAAGCCTGGATGACAGCACATTCTTTTACA GCATGGTTTACTGAATATTTTAAGCCCACTGTTGAGACCCCCTGCTCAGAAGAAAAAAAGATCCCTTC CAACATATTACTAATCGTTGATAATATACCTGATCACCCAAGAGCTCTGATGATGTACAAGGAAGATT AATGTTCTCTTCTGTTTTCTATGTGTGTGTGCTTTTTTTGTTTTGAGACAGGGTCTCATTCTTGCCCAG GCTGGTGTGATCATAGCTCTCTGCAGCCTTGAACCCCTGAGCTCAAGCAATCCTCCTGCCTCAGCTG CCTGAGTAGGTGGGACTACAGGCATGCACCACCATGCCCAGCTAATTTTTTTTTTTTTTTTAATAGAG

[0358] ACAGGGTCTATGTTTCCCAGGCTAGTCTCACAAACTCCTGGTCTCAAGTGATCCTCTTGCCTCAGTA ATGTTTTTCTTAACC ACTAACGC AG CATTCATTCTG CAG CCCATG G ATCAAG G AGTAATTTTG ACTTT CAATTCTTCTTATTTAAGAAGTATCTTTTATTAGGCTATAGCTGCCATAGATATTCCTATGATGGATCT GGGCAACATTAATTGAAAACCTTCTGCAAATTATTCACCTTTCTAGATGCCATTAAGAATGTTTGTGAT TCATGAGAGGAGGTCAAAATAGCACCATTAACAGGAGTTTGGAAGAAGTTCATTCTAATGCTTGTGG ATGACTTTGAGGGGTCAAAACTTCAATGGAGGAAGGAATTGCGGGTGTGGTAGAAATAGCAAAATAA CTAGAATTAGAAGTGGATCCTGAAGATGTGACCGAATTGCTACAATGTCATGGTAAAACTTGAAGAAA TGAGAAGTTGCTTCTTATAGATGAGCAAAGAAAGTGATTTTTTGAGATGGGGTTTACTCCTGCTGAAG ATGCTGTGAACACTGATAAAATGACAGCAAAAGATTTAGAATTTTACATAAAATTAGTTGATGAAGCAC TGGCAGATTTGAGAGGACTGACTCCAAGTTTGAAAGTAGTTCTACTGTGGTTCAGATGCTATCAGAC CATATTGCCTGGTTCAGAGAAATCTTTTGTGAAAAAAAGTCAGTCGGCACAGCAGACTTCATTGTTGT CTTGTTTTAAGAAATTGCCGGCCGGGCACGGTAGCTTACACCTGTAATCTCAGCACTTTGGGAGACC AAGGCAGGCAGATCACCTGAGGTCAGGAGATCAAGACCAGCCTGGACAACATGGTGAAACCCCATC TCTACTAAAAATACAAAACTTAGCAAGTCGTGGTGGCACGCACCTGTAATCCCAGCTACTTGGGAGG CTGAGGCAGGAGAATTGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCAAAATCACGCCACTGT ACTCCCACCCTGGGCGACAGAGCAAGACTCCATCTTAAAAAAAAAAAAAAGAAAGAAATTGCCACAG TCACCCTAACCTTTAG CAACCACTG ACTTG ATCCG G CAG CAG CCATC AACACTG AGG CAAG ACCC AC CAACACAAAAATGATGACTCCTTGAAGGCCCAGGTAATTGTTAGTGGTTTTTAACACTATTTTAAAATT AAGATATGTGCTTTTTTTTTTTTTTTTTTTTAGAATAATGCTATTGGACATTACTAGACTACATTATAGCT ACACTTTTTTGTTGTTAATTTAAAAATTGTGGGCCGGGCTCAGTGGCTCACGTCTGTAATCCCAGCAC

[0359] TTTGGGAGGCTGAGGCAGGCAGATCACAAGGTCAAGAGATCGAAACCATCCTGGCCAACATGGTGA

[0360] AACCCCATCTCTACTAAGAATACAAAAATTAGCTGGGCGTGGTGGTGCACGCCTGTAGTCTCAGCTA

[0361] CTCGGGAGGCTGAGGCAGGAGACTCTTTTGAACCCGGGAGGCAGAGGTTGCAGTGAGCAGAGATC

[0362] CCGCCATTGTACTCCAGCCTGGCAACAGAGCAAAACCCTATCTCAAAAATAAAATAAAATAAATTATG

[0363] GCCAGGCGTGGTGGCTCATGCTTGTAATCCTGGCTCTTTGGGAGGCCAAGGCAGGTGGATCACTTG

[0364] AAGTCAGGAGTTCGAGACTAGCCTGACCAACATGGTGAAACCACGTCTCTACTAAAAATACAAAAAA

[0365] AATTAGCTGGGCATGGTGGTGCATGCCTGTAATCCCAACTGCTTGGGAGGCTAAGGCAGGAGAATC

[0366] GCTTAAACCTGGGAGGTGGAGGTTGCAGTGAGCTGAGATTTGCGCCACTGCACTCCAGCCTGGGTG

[0367] ACAGAGCAAGACTCCGTCTCAAAGGAAAAAAAAATGGATACATAATGATTATATATATTTCTGGGGTA

[0368] CGTGTGATATTTTGATATAGGTATACAGTGCGCAATGCTGAAGTCAAGGTGATTGGGATACCCATCA

[0369] CCTTAAACATTTATCTTTGTGCTGGAAACATTACAGTTCTCTTCTAGCTATTTTGAAATATATGATAAAT

[0370] TGTTAACTGTAATTTCCCTACTATACTGTGAAATACTAGAACTTACTGTTTCTGTCCAGTTGTATGTTT

[0371] GTATCCATTAACCAACTTCCCTTTATCCCTTTCTCCCTCCTTTTCTTCCCAGACTCTGATAACCACTAC

[0372] TCTACTGTCTACCTCCATGAGATCCTTTATGTATTCTGGATATAGATCCTAATTAAATTCATGACTTGC

[0373] AGCTATTTTCTTGCATTCTGTAGGTTTTTTTCACTTTCTTGAGAATATTCATTGCACAAAAGGTTTTAAT

[0374] TTTGTTGAAGAATGATTTGTCAGTTTTTTTTTGTTGCTCGTACTTTTGGTGTCATATCTAAGAATCCATT

[0375] GCTAAATCCAAGGTCATTAAGATTTACCCCTATGTTTTCTTCTGAGAGTTTTATTATTTTAGCTCCTATA

[0376] TCATTTATTCATTTTGAGGGTTTTTAAAATATGGTGTGAGGTAGGGGTGGACATTTATTGCTATAAATT

[0377] GTCCTTTGAGCATTGCTTTTGCTGTATGCCATCAGTTTTGGTATGTGTGTTTTTTTTGTTTTCATTTGT

[0378] CTAAAAGTATTTTCTAATTTTTCTTGTGATTTCTTTTTTTGACCTTGTATCTATATTCAAGAGGGATATT

[0379] GGTGTATAATTTTCTTTTTTGTACAGTCTTTTGTATTAGTGTAAAGGTGATGCTGGAATCATAAAGTGA

[0380] GTTGGAAATTACTTACTCCTTTTCTGTTTCATGGAAGGTATTTTGTAGAGGTGGTCTTATGTCTTCTTT

[0381] AAATACCTGATAGAATTTGCTACTAGAGATTTATTTTTAGAAAGGTTTTTAACTATGAGTTTAATTTCCT

[0382] TAATAGTTACAAGAGTGTTCAGATTATCTGTTTTATCTTGTGAATATAAAAGATATCTTCAGATATCTTT

[0383] TATCCTGTGAGAGTTTTGTTTTTCTTTGGTTTTTGAGGAATTGGTTCATTTTTTTCTAACATTTTGAATT

[0384] TATGTAGAGTTTTTCATAGTATTCTTATTAACCTTTAAATGTCTGTGTGTAGGGGAGTCTGTAGTTCAT

[0385] TGTTTTTTTATTACTGATATTGTTAATTTGTGTCTTCCCTTTTTGTCAGTCTTGCTAGAGATTTGTAAAT

[0386] TGTATTGGTCTTTTCAACAAACAAGCTTTTGTTTTCAACATTTTTTTCTGTTTTCAATCTCATGGATTTC

[0387] TGCTTTTTATTATTTTTGTGTTGCTTTCTTTAGGTTTATTTAGTTCTTCAAGTTTCTTAAGATAGATTTGC

[0388] AACTGTTTTTCTTTGCTGATATAATAGTATCAGTTTAAGAGCAGGGCTTGGTGGCACATGCCTGTAAT

[0389] TCCAGCTATTTGGGAGGCTGAGGTGGTAGCATCACTTGAGCCTAGGAGTTTGAAACTAGATTGCGCA

[0390] ACATGCAAGACCCACCCCCCCCCCCATCTCTTAAAAAAACTAAAAAAAAAATAATGGCACAAGCTTAA

[0391] TGATATTAATTCACTGTAGCACTACTGTATTTGCATCCCACAGATTTAGTATGCTGTATTTTCATTCAG

[0392] TTGAATATTGAACTAGCCTTGTGGTCCTGGGATTAACCTTATTGTCATGTTTATTATGCCTTTTACAAT

[0393] TGCTGGATTCTGTATGCTAATATTTTACTAATGATTATGAGGAATATTAGTATGTAATTTGGGGCTTCC

[0394] ATTTGACTCAAAGATTATTTAGAAATGTGCTGTTTAATTTCCAGGTGTTTGGAGATTTTCCTATTAACTT

[0395] TCTATTTCTAGTTTAATTCTATTATGGTCAGAGAACAAACGTTTGTGGTTTTTTTTTAAGCTTGTGAAAG

[0396] TTTGTCTTATGACTCAGAATATGGTCTGTTTTGGTGAGTGTTCCATGTGCATTTGACAAGAACATGTAT TCAGCTGTTAAGTAGAATGTTATATAAATATCAATCAGATCAGGTGGATTGATGATGTTCATTTCTTCC ATATTCTTACTGATTTTCTGTCTACTAGTTCTATTACTGAAAGGAGTGCTGAAGTCATCAAATATAATT AAGAATTTGTTTTCCTATTTGTAATGTTCTGTAAGTTTTTACTTCATGTTCTTTGAAGCTCCATTATTAG GTGCATATATATTAGTTATGCTTTCTATTATGAAAATTATATTTGAAGTGAATTACTCGTAGACTACATA TAGTTGGGTCATTTTAAAAATTCATTCTAACAATCTTGTCTTTTAATTTGTATCTATAGACTATTCACAT TTAATGTAATTTTGGCATGTTTAGATTTAGGTTTACCAGTTTAGTAATTTGTTTTCTGTTAGCTGCTTCT GTTTTCCATTACTCTGTCTTTCCTGCATTCTTTTAGATTGTTTGAACAACTTTTAGCCATTCTGTTTTAA TTTACCTGTTGTGGCTTAAAAATTCTTAACTCTCCATATAGTTTTAGTGATCACTCCAGAGATTACATT ATAAAAACTTAACATTTTCACCACCTGCTTTAAAATAAATTCATTTCTTTAAATGGATTATGGTCCACTT AAAGAAATGTTAAAACTACGTAGGTCTCTTTATCTTCTCTCCACCTTTTCTCTTATTGTTGGCTGTATG TTACGTTTCTATTAATTG AAAG CTTCATTG GG CAATG CTATTGTTTTTACTTTCAACCATTAAAC ATATT TAAGGAAACTAAGAGGAGAGGGTTAATGTATTTTTGTCTGCATGTTTACCATTTTGCTTACTCCTCAA CCTACTCTTCCAGGTTTCCTTCCGGTATTATTTCCCTTCTGTGTGAGGAATTTCTTTTAGCAATTCTTT TAGAACAGGTCTGCTGGTAGCAAATTCTCTTAGTTCCCATTTATCTGAAAATATCTTTGTTTTATGATT GCTCTGAAAGATACTTTAACTGGATATAGAATTCTACCTTTGATAGTTTTTTTCTCTTTCAGCACTTTAA AATGTGTAACTTCCTTCTGGCCTTCATGGTTTCTGCTGAGAAACCTGTTGTCATTTGAAGTGGTGTTC CCCTATATTTTATGGATTGTTTTTCTCTGTTTTCAAGATAATTTTTAGGCTGGGCGCAGTGGCTCCCAC CTGTAATCCCAGCACTTTGGAAGGCCGAGGCGGGTGGATCACCGGAGGTCGGGAGTTCGAGACCA GCCTGGCCAACATAGTGAAACCCTGTCTGTACTAAAAGTACAAAAAACTTAGCCAGGCGTGTTCGCG GGCACCTATAATCCCAGCTTCTAGGAAGGCTGAGGCAGGAAAATCGCTTGAGCCCGGGAGGCGGA GGTTGCATTGAGCTGAGATCACGCCATTGTACTCCAGCCTGGGCGACAGAGCAAGATGCTATCTCA AAAAATAATAGTAATTTTTTGTGTTTCATTTTCAACACTTTATGATGTGTGAGAGTGTGGAATTCTACG TATTTATCCATTTTTGGATTCACCGACCTTTTTGAATCTGTAGTTTTATGTCATTTGTCAGATTTGGGAA GGCTTTTGACATTATTTCTTCAGATATTTTTAATCATCCTATTCTTTGCTTTTAGAAGTTCACTGACACA GATGTTAGATCTTTTTGTTACTGTCCCATAGATCCCTGATGTATTACTCTATTCTTGAATTGCTATAAA G AAATG CCTG AG ACTAG GTAATTTATAAAG AACAG AG ATTCAGTTG GCTCATG GTTCTGCG G ACTGT ACGGGAAACATAGCAGATTCTGCTTCTGGGGAGGCCTCAGGAAACTTAAAATCATGGTGAAAGGTGT AAAGGGGAAGCAGGCATATCTCTCATGGCTGGAGCAGAAGCAAGAGATGGGGAGGGTGCCACATA CTTTTAAATG ACC AG ATCTCATAAAAACTCACTATCACAATG ACAGC ACTAAG G GG G ATG GTGTTAAG CCATGGGAAACCGCTTCCATGATCCAATTTTCTCCCATCAGGCCCCACCTCCAACATTGGGGATTAC

[0397] ATTTGAACATGAGATTTGGGTGGGGACATAGATTCAAACCATATCACCTGGATTCTGTTCATTTTATTT TAATCCCCACAGCTACATCAATTGGAGACCTGGTTCTCTCCCTGCTCTCAGAATGTTGGCTCTTTTGA AGATCCTATTGTTGCCGCTGCCACCATGGGGTTACGTGAGAAAAGTGAGGGGAAAAAACTGAGACA CTATCTTTGAATGTTATTTCTTTGCCTTTTTTTTTTTTTTTTTTTACTTTTTTTCTTTTAAAAAGTAAACTT TTTTTAGGCCAGTCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGCAGA TCACAAGGTCAGGAGATCGAGGCCATCCTGGCCAACGTGATGAAACCCCGTCTCTACTGAAAATACA AAAATTAGCTGGACATGGTGGCGCGTGCCTGTAATCCCAGCTACCCGGGAGGCTGAGGCAGGAGA ATTGCTTGAATCAGGGAGTTGGAGGTTGCAGTGAGTTGAGGTCGCGCCACTGCACTCCAGTCTGGC GACAGTGAGACTCCATTTCAAAAAAAAAAAAAAAAAAGTATGTAAAATGTAAACTCACTGATGGTTTCA TGATGATTCAGATCCTTGTCCTCTATCCCAATCGTCTACTGCTATTTACTTCCAGTGTTGTCGATTAGC TGCTCTATGTGTTCTGTCCAAGTTTTATAGTTGGACTAAATCTTTGAAGTGTGTTCCCACCACCCCCG TAATGTGTGACTACTAATATTTCTGCTCAATTTGTTCTTTTTCCCCTCCTTGTTTTTATTTTTATTCTTG GCTTCCTAGGGGTTGCTCCTGTCTTTCCATAGCTTAATGTCAAGCTAAAGATTTGTCAGAGGTTTTGT TCAAATATTTCAAGGCCAGTAAGGTTTCTATTCTTTCTTTGTGTGTCTATCTGTGTATCAGGGAGTATA TTCAAACTTCAGGCCACCATGTTGCCTGACCTGGCTTTTGCTTTCCTCCGGGCTCCTCTGTGTCTCC TGTGTGCATGAACATGCAGAGGCTCAGTCAGTCAAGGATGTGTGGAGGTGTGGGCCCTGTCCAGAC CCTGTAGCACGTGCTTGCAGTGTCCGTTCAACTAGTGGAGTGTGGAAAGTGTATTAAGCCCCCAACT TGCAGTGGAGGTTATCACTTAAATTCACAGCACTCCAAATCAATTGTCAACACCCTCACACACACACA GTCTCTAGCTGAACACATGCCAACAGAGGGAGAGATTGGTCAGTCATCTGAAGAAGGGATGGCAGC AGCCTCAAGCAAAAATGCCACAGATGGCTGGGCATGGTGGCTCACGCCTCTTATTTCAGCACTTTGG GAGGCCGAGGCAGATGGATCACCTGAGGTCTGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAA CCCTGTCTGTACTAAAGATACAAAAATAGCTAGGCATGGTGGTGCATGCCTGTAATTCCAGCTACCT

[0398] GGAAGGCTAGGACAGGAGAATCGCTTGAATCTGGGAGGCAGAGGTTGCAGTGAGCCGAGATCGTG CCATTGCACTCCAGCCTGGGCGACGAGCAGAACTCTGTCTCAAAAAAAAAAAAAAAAAAAAAAAGCC ACAGACTGTGATGTTCTTACTCAGGTTCAGCCTTTAGCTGAAGTCCAGAGCACTGAAATGGTTGTTTT GACGGTTTTGTCCAGCTTTATAGTTGCTTTTGGGGGAGAGGATTTATCAATGTACTCATTTCATCATG CCAGAAGTAGTAGTATTGATATGATTTTTTATATATATCTTAGAATTTTGAAGATACTGTTTTCTTATTT TCTAGCATACAACAATCTGATTCTTGTTTTTTATTCCTTAGAATTTTATTGGTACTTTCTTATTTCCTTTT GAGTTTAACTTAGCAGGATTTGTTTAATTTTGTATCCCTCCAAGCACCCAGGCTGGAGTGCAGTGGTA CAATCATGGCTCACCACAGCCTCCACCTCATGGGCTCAAGTGATTCTTCCTCTTTGGCCTCCTGAAT AGCTGGAACTACAGACACATGCCACCATACCTGGCTAATTTTTATTTTTTTTTATTTTTGGTAGAGATG AGGTCTCGCTATGTTGCCCAGGTTGGTCTCAAGCTCCTGAGCTCAAGCAGTCCTCCCACCTCAACCT CCCAAAGTGCTGGGCTTACAGGCATAAGCCACCATGCCCAGCTCTTATTCTTTCTTTGTTAAAAAAGG AACTTTGGTTCTGAAGACTCTTATTTGCCTTTTGGCTCAAGGAGAAATTCTTAAATTTTCTTTGTTATTT CTTCTTCTTATTTTAATTCTCATAAAATTTCTCTTAGATGTATGTAGGATAATTTAATCTGTATTCTGGG

[0399] ATATTAACTTTACTCTCATAATTTAAGCTTTCATTTTACTTCATATTTTTTTTTTAACTTTTTGTTAAAGTA CC ATG G ACTTTAG CTTTGTCCATTTTG CTAGTTAACTCCTTTTTTAG GTTTATTTCAACAG ACATTTTAA ATTTCAAGCTTGTTCTGTGCAATTTATTTATTTATTTATTTATTTATTTTGAGATGGAGTTTCACTCTTGT TGCCCAGGCTGGAGTGCAATGGTGCGATCTCGGCTCACTGCAGCCTCCACCTTCCAGATTCAAATG ATTCTCCTGCTTCAGCCTCCCAAGTAGCTGGGACTGCAGGCATGTGACACCACAACCGGCTAATTTT GTACTTTTAGTGGAAACGGGGTTCACCATGTTGGTCAGGCTAGTCTCGAACTCCTGACTTCAAGTGA TCCACCTGCCGCGGCCTCCCAAAGTGCTAGGATTACAGGCATGAGCCACCGTGTCTGGCCTCTGTG CAATTTAGTATTTTTGTTTTCTTTAGTGAGTGCAGCTCCTCCATAATAGCACTATATACAATATAATTTT CTGTGCTATGCAGTATATTAGCCAGTAGCTGCAGTGGCTGGGAATGTGGCCTGTGAGAGTGAGAAA CTAAATTTTATATTTTATTTAATGTTAGTTTATATAAAATTAAATAGCCATACATGTCTAATGATTACTAG ATTGGACAGCACAGCTCTACAATTTAAGAATCCTTATACTTTTTGGCTTCAAAATAATTCTGATGCCTT AGTTCATCTCCTCATTCAATTG CATGTCTGTTTTTTATGCTCTTG GTTTTTTTTAG GTGTCTAAAG GTTA ATAAAGGTTAAAAATATTGGAAGTTAGAGTAGGTTTCCTCAACACTTAAGTGAGTTTCTTCTGGAGAA AGTGAATATTGAATATAAAAATCCATTAATTTCTAGTTCTACTAAGTGAGCTAGGCAGTCCTTGCTTTA

[0400] GAGAATATGGGTACTTCTTCTCAATATGTGTATGTGTGTAGCCTCTGTCCCTGTGGTGGCCAGAATTT

[0401] ACTATAATTCTGTCTCTGGCCATAGTGTCCAGACAGAAATCCCTGTAAGCTGATTACCCTTTTCCACC

[0402] AGGTTTAGATCAGATACAAATATATGGGGGCAAAGACTGAGTTACTCTTTTTTTTTTTTTTTTTTTTTTT

[0403] GAGACGGAGTCTTGCTCTGTCCCCCAGGCTGGAGTAGTGGCGCGATCTCGGCTCACTGCAAGCTCC

[0404] GCCTCCCGGATTCACGCCATTCTCCCGCGTCACCCTCCCGAGTACCTGGTACTACAGGCACGTGTC

[0405] ACCATGCCCAGCCAATTTTTTTTTGTATTTTTTTTTGTATTTTTAGTAGAGACAGGGCTTCACCGTGTT

[0406] AGCCAGGATGGTCTCGATCTCCTGACCTTGTGGTCTGCCCGCCTCAGCCTCCCAAAGTGCTGGGAT

[0407] TACGGGCGTGAGCCACCGCGCCCAGCCAGACTGAGTTACTCTTGAACATGTGATTTGCATCTAAACC

[0408] AAATTTGTTAAAAGTCTTTTTTTTTTTTTTTTTTAAGTAAGAAAAGGCAGTGATTTTGATTTGTAATGTCT

[0409] TTTGTTAGGAGAAGTAAAAGAAAAAAAATTCTTGAAGAAAAGTGAGCCAGAATTACTGCCTAGGGAGT

[0410] GATAGTCATGTAGGTTCACAATGAAGTTTAGAAGTGCTCTTCGTGGTTCCGTTTCCTCTTTTGCTTTA

[0411] GTGTTCAGGAAACTAAAAACTGACAGTAGACTAGTTGGAAGATAGACTAGGTTTTTTTTTTTTTTTTCT

[0412] AGTTAACCTAAGTCAGAAGGGTGATATCACTAGAGACTTGGAAGTAAAAAGAGCTACCTGCAAAGAC

[0413] TTGAAGTACTAAGATTACCTAGAATCTGAATGCCCTGTGTTACTCTGCAGATAGGGCATTTTACTGTT

[0414] ATGAAGAGATAAGATCTATTGTAAATAGTCTAAACTAATAATAACGAGTAAGTATGGAATTGGCGTTTT

[0415] TCCTTTAAAGTTTTAGCATATAATTTTGAAATGTTTTAAGAATATTTTTGAAATGTTTCTATTTTTTAATT

[0416] TCTCTTTTAGAAGTCTTATCTAAAATAAGCATGTATATCTTACATGTAAGGAATTATTAACTTCATTTTT

[0417] TCATAAAAATAATCAGAGTAAGACTTTCAACAGATGTCAGGATAGCTGAAGTTCTCCATCACTGTCAT

[0418] ACGTTTCACTTATGACAGGTTTGTAATTTCTGTTAGGGAATGTCATCTAAGTGCTCTGCATCTGGTATT

[0419] TTCTCCTGCACCCTCATGACAAGAAAAAAGCCTTTGATTATTTCTCTTTTCTCTCTATTTACATGTTCA

[0420] CCACTGCCTTCCATGTTCAGATGTGATCTACATGCAATGATGATTACTCTTTCCTTCCTTTCCCCCTT

[0421] GCCCTCTTTTATCGTCTTTCTTTCTTCCTTTTTTTGGTTGACCCTGTTTAAATGGGATCTATCAAATATA

[0422] CCAAGTTTCAGTGAAAGTTACTTCCTTGTGTTAAAAGTCATGACTTTCTCTTTTATTTATACACTTAATA

[0423] ACTTGATTATATATACTTGAATTTTGTTTTAGTGCAGAATAATTTTATAATCTTTCTGAAGGTATTTTAAA

[0424] GTGGCAGTTAATTCCAACATTTGTAATACCAACAATGCAGATAACTGAGTTGAATGACAACAGCATGA

[0425] ATAGCCTTGATTAAGTTGTACATGTGCAGATAGCTACTGTGTATATCATGCCTGCCATCTGGACAACA

[0426] GTGATTTTTTTTTCTTTTTTTTTTTTTGTTTGAGACAGAGTCTCAGTCTGCTGCCCAGACTGGAGTGCA

[0427] GTGGCGTGATTTCGGCTCACCGCAACCTCTGTCTCCCAGGTTCAAGTGATTCTCATGCCTCAGCCTC

[0428] CTGAGTAGCTGGAATTACGGGTGTCCGCCACCATGCCTGGCTATTTTTTGTATTTTTAGTAGAGACG

[0429] GGGTTTCGCCATGTTGGCCAGGTAGGTCTCGAATTCCTGACCTCAAGTGATCTGCCTACCTTGGCCT

[0430] CCCAAAGTGCTGGGATTGCAGACATGAGTCACTGTGCCTGGTCAGAAAACAGTGATTTTTAAGATGT

[0431] CATCAATTGTATGGTAGAATCTGAATTCAAAGATGTTAAGAAGGGGATGGGGGAAAGGTGTCTCTTA

[0432] GAACATGTAAAAGAACATGTTATTTCTGTCAACTTCCAAACTTTTATCTCCAGCCACATCTCTTACTTG

[0433] ATTTCAGATTTGTATACCCAGCTCCTGTTTTACATCTCCACTCTGGTTAATGTGCCTCCCGGGATATTT

[0434] TAAATATAATTTTTAATTCTGCATCCTATGCCTTGTCCTCCCAACCTCAGTGTTCCTTCTTCATTCTTTT

[0435] TGATTTTTGGCTCTTACATCCTTTGACTTAGGTTATAAACTGTAGAGTCGAGGATGACTCCCTTTTATC

[0436] ATACCTCACATCCAATTTACCAGCAAATCCTATTGACTGTACCTTTATAATATATTTAGCATCTGACAC

[0437] ATCTTATCATCTCTTCCACTATCAGTCTGATAAAAGCCACCATCATCTTTCACTTGGCCATCATTTCCC ATCTGGTTTCTTGGCATTTACACTATAGTTCATTTCCAGTATAGCAGCCAGAGTAATACTTTAAAAATA TAATTGATCATATTGTTTCCTTTTTTTCAAAAGTAACTTCATTGAGTTCACCTACCATACAAATCACTCA TTTAAAGTGTACAGTGCGGAGGTTTTAGTGTATTCAGTGTGCACAACAACCATCACCAAATTTAATTTT AGAATGTTTTCATTAGCCCTAAAAGAAACCCCACACCCTTAGCCATTCTCCCCCAATCCTTATATTCC CCCCATTTCTAGGCAATCTAATTTCTGTCTCTGTGGATTTTTCTATTCTGGACCATTTTATATACGTGG AATCATACACTGTGTGGTTTTTTGTGACTGCTTCTTTTACTTAGTGTAATGTTTCCAAGGTTTGGTCAT GTTATAGAATGTATCAGCATTTTGTTTCTTTTTATTACCAAGTAAAATTCCACTGAATGGATATGCGAC ATTTTATTTATTCATCAGCTGATGAATGTTTGGACTGTTTTAACTTTTTGGCTATTGTGAATAATGCTGT TATGAATATTCACAAGTTTTTGTGTCTCCTCCTGCTGTGGACTACTGTTTCCCTAACAGAACGTATTAA TTTTCTTTTGTACAAAAGCCACTCCAAAGCATAGTGCTTAAAACAACCACTGCTTGGGTCAATGAGCA CACTATATTCTGCACTGCACTAACTTTGGCTGTGCTCATTCATGTCTGTGACCAGTGGTGGTTTTAGG TAGATGGCTAGTCTAGGATGGTCTTGAGTGGACAACTTGGTTCTAGTAAACTAGTCCAGGCATGTTC TCATAGAAAGGCACAGGTGAGAGAGTGAGCAAGTTCAATTGTACAAGAGGACAAGACTTGCATATTT GCATTTTAAGCTTCTCTTTGGGTCATGTTTGCTAATACTACATTACAAGGTATCACAAGAGCAAGGAG AAGCCCAGGGTCAGAATGGAAAGGGGATTGCAGAGTTACGGGTAAAAGATGTGCCTACAGAGAAGC CATTAATTGGGGGTCATTAATGCTATGTCTGTTGCACATACCAATTTTGCTTCTACCTTAATGCTTTTT GCATTTGTTTCCCTTCTGTTTGAACTAGTTTTCTCTTACATACCTGCATGCTGAACTTGTTTCACTTCC TTCCTATCTCTGTTCATGTATCATCTTACCAATGAGACCTTCAAGTTTTACCATACTACAAAATGAATA GCCACCCACCCCGATCCTGCTCACAGTCTCTGTTTTTCTCTATAACTTTTTATGACCATCTGACATTG TCTGTTTTTTTTTTTAGCGTTTATCTTCCCTTAACTAGAATGTATGCTCTATGAGGTCAGGGACTTTAG

[0438] TTTAATTACACTGTCTTCATTGCCTAGAACCCTGGCACTCATTAAATATTTGTTGAATGAAAAATTAAT CTACATTG ATCC ATTTTTACCTAAATTG G AATTATCTTAAAGTTCTAACCTG CCTTCATG CTATG GCAT GTATAAAGTGTCAGTCTTTTGATTAGAATACCTAATGATGGAATATTTCTTCTACTTCTTATAGAGACA TAGACCATGCAATATATGAGTAATTCTACCATTTACTTAGCTGTCTGACTTGGGCCAAGTTTTTTTTAA CCTCCCTGTTTCCTCATCTGTAAAATAGGGGTAATAATAGTCCCAGCCTCATGGAGCCTGGCACAAG GTAGGCACTGTATAAGGTTGGTGCAATGTGTATTGCATAATATTTTTTATCACCTACTTGTTATTGGAG TATATGGCACAGGGAAAATGGAATTGAAAGCTGGAGCAATCTTATATTATGGAGAAGTTGCAAAATCT TTGAAAACTATTTTTTCAAAGGGACAAAGCACATAAAGCAAATGAAATAGGTGATTTTTTTTTCATTGA ATGCATCATAACATTATATCCTTAAAACACTGTCTTACAAAGTGCTCTCTGAAAAATACTGTTCTTTATT TCAGGGTTTACGAAAAAGTACATAAAACTAGTGAGCATACATCTTAACTCTCTGAGAGTCTTATAAGT ACCATCCTAGATGCATGGAGAGAAGATAATTCATTACTTACACTAGGTCATGCCTTAGGTCGTTAAGA CTTAAGTATCTCATGGAACCCCAGTTGAGAAAGAACAAAAATATAACATCTTGACTAAGGTGGCTAGT GCTTCTCTGATCTTAACTATTATTTCTCTAGCCTCAGGTGAGCCTTCTTGAATGTGATTTCATCAGTCT CCTCTAAGCTTACCCAGAATATAGAATTTTTAATATTTTATATAGCCAGCACTTATAAACTACCTGCTT CATGCTAGGTAGTATACTTAGGTGCTAGGAGTAAAACTGATCAAGTGGGGTAAGTTCCAAATTCACA GAGCGCACAGTCCTAACAGGCTGTCATGCCTCAGTTGTTTATTTGTGACAGTGTTTCCCACAGACTTT TAATTTTGGAATGATAGGATGTGGTGCTCTGGAATGGTGTCCCAGGGTTTTGGAGAACTGAGAGTAA CCTGGGAAAGCAGGTTACAGTGAGAGAAAGTTATGACCAGGAGTTGTACCAAAACGCAGGAAACAT GATATGTATATTGTTATGGTGCATAAAAATACTTACAATTAAAAGTCCTGAACCTACACTACATCTATT GTTTCACATATTTTCCTTCAATTTAAATCCTGCTCCAAATACAGCTCCTTTCCGAAAATTCAGTTTTATG

[0439] TGACAGAAATTTGATCTGTTTCACTGAAAACCCATTTGAATAGTAATTGTGAGCAATTGTTGAATTTGT

[0440] AAATGTTACGTAAATTTAGTGGATGACTTTGTGGACAGTTTGACGTTATGGACAGTTATTCTTGATACT

[0441] GTTTCCCCTCCTTTCCCCTGCCATCCCTGAAACTTTAGGGCTTAATCTGCTTTTAATTAGCCAGAAAA

[0442] AAATGTTTGATCCTCTTATTCAGTTTTAGATTATTTTAGATGATTTCTAAGTTAAACTCTAAGTTAGAAT

[0443] AGTTTCTGCTTATTGATTTCATGAATATCACTTCTCTATTTCTACTTCTCACCTTCTGCCAGGCCAAAG

[0444] GAATTGTGGAACTATGATCATCAAACTCCTAAATCATCAGCCTTTTCCTTAAAAGACTTAAAAGGGTTC

[0445] TATCTATGTAGACACTTGTCTGGCTCCTGATTACAGTTTTACCATTCTCAAGTGATACTATTTGTTTCA

[0446] TCACAGTCCACATAATTCAGGGTCAAGATACTATTATGAAATGACTGTAAAAATTACTAATACCTTTGG

[0447] CTCTCTAATTTTTCTCTCTTTTCATCATATGGGCCTGACAAAATGCCCGCTACCTGCCTGCACTTAGG

[0448] CAATTGAATGTAGTGCTTTAAATGTATACCAAAACCCTCAACAGGGCATCAACAATGTCTGGCAGTGC

[0449] AGCTGCTTCTTCACTTTCCCAATTAAAAATGCGTTTGCTGGCTGGGCGCAGTGGCTCATGTGTGTAA

[0450] TCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCACTTGAGGCCAGGAGTTCAAGACCAGGCTGG

[0451] CCAACATGGTGAAACCCCGTTTCTACTAAAAATACAAAAATTAGCTGGGTGTGGTGGCGTGTGCCTG

[0452] TAATCTCAGCTACTTGGGAGGCTGAGGCAGGAGAATCGTTTGAGCCCAGGACGCGGAGTCTGCGGT

[0453] GAACCAACATCGCACTACTGCTCTCTGGCCTGGGCAACAGAATGAGACTCTGTCTCAGAAAAAAAAA

[0454] AAAAAATTCATTTCCTCCACTCATTGCAAACCTCTCACAGCTCCCACTCCTATCTGTGGAATTCACTTC

[0455] AAACTTTACTGAGAAATTAAATGCAGCTCTTGTCATCTTTTCACCACCAATTCTACAAACTTGTCTGCA

[0456] TTGGTCCTCTTGTTCTGTCTTCCTTTCATTTGTTATCGAAGACCATTCCCGACAGTCTGATTTCTCTAC

[0457] TTGTGACTCAGATTTCATCTTTCCTGCATCTCTGTCTTCCATATCATTCTTCTCCCCTCGATTAAATTC

[0458] CCTTTAGCCACAAACATGCTCTATTATCTCCCAGCCCCAATACATCTGCAAATGTATGTAAATAGGAA

[0459] TGACCAAATATGTACAGATATACAATTCCTACCTTTCCTAATGTCTTCTAGCCACTATTATGTGTTCCT

[0460] ATTCTTATCTAATAAATTTTCTTAACTGAATATTTTTTCCTTCTACCTCAGTGTCTGTTTCTTTCTTTTCA

[0461] GCCATTTTTGGTTTCTCTTGTAAATGTTTATGATCCCCAGGGCTGAGCCTTCTTGGCCTATACTCTCT

[0462] TGTAGGTCTGCCTCCCAGTATGCTAGTGACACCCAAATATGTCTTCAGCCTCATCTCTCCTCCAGGG

[0463] TTCTAAACTTGCATAACCAGCTGCCTTCTTGATCATTTAGTAAGCCTCTCCTGTTGGTGACATAATGC

[0464] TTGATTTCTCTCCCTCATGGCATCACTGTCCACCCGTTGCACACATCAGAATTTCAGAATCAGCCTTA

[0465] ATTCTTAGTTTTTTCTCACTCTTCCTCCATGTCTAATCCAGTAGCCCTATCTCCACTGTTTTCACCTTG

[0466] GTCCAAGCAATCATCTCTTGCTTAACACAACCATAGTTTCAACTAGTCTTCCTCCCTGCATTCACTCTT

[0467] GGCCCAAGCAATCATCTCTTGCTTAACTATGGTTGCTTAACACAATCATAGTTTCAACTAGTCTTCCT

[0468] CCCTGCATTCATTCTTGGCGCACCGTAATCCATTCTTCACTAGAGTGATAATTAGAGGTACTATAATA

[0469] TATACTGCTCTAGAGTTATATTGTCTAGAATTTACTAGCTGAGTGGCCTTGAGCAATATACTTAACACT

[0470] TATGCCACAATGTGCTCGTCTATAAAATGGGATGGTATATTTATCTGTTCTCTGATTGCTATAAAGGAA

[0471] TACCTGAGACTGGGTAGTTTATAAAGAAAAGAGGTTTAATTGGCTCACGGTTCTGCAGGCTCTACAG

[0472] AAAGCATGATACTGGCATCTGCTCACCTTCTGGGGAGGCCTCAGGAAACTTACAGTCATGGCAGAA

[0473] GGCAAAGCAGGAGCAGGTGCGTCTTACATGGCAGGAGCAAGGGGTAGGGGGAGGTGCTACACACT

[0474] TGTAAACAATCAGATCTTTTGAGAACTCACTCATCAAAAGGACAGCATCAAGAGGATGGTGCTAAACC

[0475] ATTCATGAAAGATCCACCCCCATGATCTAGTCACCTCCAACCAGGCCCCACCTCCAACATTGGGGAT

[0476] TACAATTTGACATGAGATTGGGTGGGGACACAGATTCAAACCATATCAGAAGTAAATTGTTAGTAAAA TATAAATCAGATTATGTCACACATACCTGTTTTTGAAACTTTAGATTCTCATTGCTCTTAGAATAAAATT

[0477] AAAACTCTACTTACCGTGGCTTTCAGGATCCTTCATAACCTGGCATATTGCCTAATTTTTCTGATACCC

[0478] ATCTTGTTTCTACTCTCCCCTTGCTTACCATATAGCCACAGTCACTATCTTTAACTTTCTAGTTGGAAA

[0479] CATGGCTTTTTGTGGGGTGTATTTCCTTTTACTTTCTATTGTTTTGGGACCAACTTATTTACGTCAGTT

[0480] TTGTGTTTGTTTTGTTATATGTAAAAATAGTGCCTTAAAAAATCAGTTTTTTTTTTTAACCTGGTGAATC

[0481] ATTTGTTTTATCTTTATAAATGCTGGGACGAGAGGCCTACTCCTTTTTTCCAATTTTGTGAGAGATTGG

[0482] TAAAATTCTTAGAAGTGGAATTGCTAGGTCAAAAGATAGAAATGTTTTCAGATGGATGATTCCTATTGA

[0483] AGTAAATTTTTTGAGAACTTAACATGTCCAAAAAGGTTTTCATTTGCCCTCATGCTTGACTGGTAGTTT

[0484] GCCTGGATGTAAAATTCCAGATTCACAGTCATTTTTGCCCAGACAGTGAAAACATTATTCTACTATCTT

[0485] TTAAAAAATAACAGTTTTATTGAGGCATAATTCATATACCATACTATGTGCAATTTAGTGGTTTTTAATA

[0486] TATTCATAGAGTTGTATAGCCATCACCGCAGTACATTGTAGAATATTTTTATCACTCAAAAATGAAACC

[0487] CCTGGATTTATTAGCAGTCATTCTCTGTTCCCACCAATTTGCCCACCCCCCAGCCTTAAGTCAACAAG

[0488] TAATCTACTTTCCGTCTTCATTGTCTTTTAATGTTGCTGATGAAAAGTCTGATGCCAAATTAATTCTAG

[0489] TTATAGGAAGCTTTTAGAGTTTTCCGTTTTGAATTTCTGGAATTTAATTATGTAAACTAGGATTTATGTA

[0490] GATATGAGTCTTTTAATTCATCCGCCTTAGCCTCACTGAGCCCTTTTACTCAGACCATTGGTGTTTTTA

[0491] ACTCCAAATATTTTTAGCATAATCTTTATTTATTCTATTTTCTTCATTTAGAACTCTTACTAAATGTATTT

[0492] TGAACTTCCCAAACATATTCTTTATATCTCTTCAACTTTTTACTTGTATCACCCATTTCTTTCTTTCTTG

[0493] CTCTCTCTTTTTTAACCTCTCTACCTTCTGGGACATTTCTTTGTGTTACATATCACTACTATGATCTTTA

[0494] TCAATACTACTTCTGTTATTTACCCCTTCTCCTCAAGTGTTTTCTTAGTAATAATATTTCAGTTTTCTCC

[0495] TTGCCCATTTATTCTGTTTGTTCATTGTGATCTTTTTCTTTCCTCCCATTGGATATTCATAGTGTCTTGT

[0496] GATTCTTGTTTATTGAATAAGGACTAAATTGACAAAAACTTTGCAGTTACATAGGTCTAGGATTCTTTT

[0497] CTAAATGGGAAATGACTACAAGTGTCATGTATTCATTGACTGGCTTTCCTCCAGGGTGCAGGGATTTT

[0498] AAGAGGCAGGCTTAAGGCCACCCCAGTTACCAAAGTAAGGACAGCTTTACTATGTTTATTCCTGGAA

[0499] GGAGCTAGCTTACTTACTTAGTATCCTCCTCCTTCAGTATCTTCCCTCTTTCCCTCTCGCCCTCCCAC

[0500] TTTTCCTTTCTACTTCAAGTATATAGTAAAGTGTAGGGAATAATATAATAACTATGTACCTATTACTCAG

[0501] TTTTGTTGAATTGTCTTATATATGCTTCAGATTTTTATAAACAAAAAAATTATAGACACAGATATAGCAC

[0502] CTTACAGTCTTACTTTGATACTTTTCTCTGCCCTTTCTGCCTTTTCAGAAGTAACCATTATCCTGAATTT

[0503] ACTGTTTATCATGCCCATGCACATTTCAGATACTTTTGCTGTGGGTGTAGATCCACAAACAATCTAGA

[0504] ACGTTGATTGCATGTTTTTGTGAACCCTGAAAGAACCAACCCTTTAAGGCAGATTCTGAGTGGCTAAC

[0505] AGTCCAAATTCAAAATAGACCCACGCGATCCTTTGCAGACATGTAGAGATCATATGTGTACTCCGCAT

[0506] TCCTGGAAAACCTATACACCCAGTAACTTTAGGACTTTCATAGCTGTCTGTTCCTATTTATGCCACCT

[0507] GAATTAACAGCTACCAGAAAATACCATTTGGCCTTTTGTACCTAACAAACACTCTGTGACCTGCCTCA

[0508] GCCAATCAGAACTGAACAAGTTTGCACCCCTCATTTGTATAGTGGACCAGAGTGGGAACCTGACTGT

[0509] GAACTTTCTCTGTAAATGACAACCCCTTTTCTTTGTTCTCTCAGAAGGCGCCTTTATTTTCTACCAAGG

[0510] TACATCTCCACGGTTTGCAAACTGTTTGCTGGAATAAAGCCTGTTTCTTTTTTAAGAAAGAAAATCTTT

[0511] TTCTGTAGATTGTTGACATTTTAAAAGTTGTATATATCCTGAAACTTGCTTTTTCATCAATATTATGTTT

[0512] TTGAGATGTATTCATGTTGATAAATATAGCGCTAGCTTTTTGTTTTGACTTAATATGTGGTATTTTGTTA

[0513] TACAGATGTACCAGTTTGCCATTTTTTCTCTCTTAGGGAACATTTGAGTTGGTTCTAGTTTTTTGCTAT

[0514] TATAAACATTGCTGCAGTGAAAATGTCTTGTACATATGTGAATATAAGTAGCTACATGATAGGATATG CTCATCCTTAGCTTTACTCTAGATATTGCCAGTTTACTTTCAAATATTTATATTATACCACATGTAGAAT

[0515] ATGATAGTGTTTGTTGCTACATGTACATGATTACCAACTCTTGTATTATTAGGCCCAATTTTTTTGCAG

[0516] TCTCACTGATTTTTCATATGTATGTATGTATTTTTTGAGACAAGGTCTTGCTCTGTTGCCCAGGTGGG

[0517] AGTGCAATAATGCATTCCTGTCTTATTGTAGCCTCAAACTTCTGGGCTCAGGCAATCCTCCCACCTCA

[0518] GCCTCTCAGCCTCTGTTAGCTGGGAGTACAAGTATGTGGTACCGCATCCAACTAATTTTCTTTTTTTT

[0519] CTTTTTTTTTTTTTTTTCTAGAGATGGGGTCTTGCTATGTTGCACAGGTGCTGGGATTACAGGGATGA

[0520] GCCATTGTACCAGGCCTGGTTTTTCATTGCATTTCTTTGATTACTAATGAGGTCATTTATTTTATGTGT

[0521] TTATTAGATATTCGAATTCCCTATAGTGAACTACCTATTCATAAGTCTTTTGCCCATTTTCTTTTGGATT

[0522] AGTTGACCTTTTCCAAAAGGATGGCCACTTACCCTGGAAATATTTATTATATAGTCCGTTCTGTTCCC

[0523] CACTAAATTATAATGCCAATGTGAACCATATGCTGTGTAAATAAATACCTGTGCCTCTGTTTCTGAGC

[0524] CCTCTATTCTGTCTCTTTGGGCTTTCTGTCTCTATGCTAGTATCATTTCTCTGTAAGTCTTGTTTTCCT

[0525] GGTAACACCAGTCTTACCCTCCTTATTATTCAAAATAGCCAAAGGCTACTATTATACAGTGCTTCCATA

[0526] AAAATTTTAGAATCAGGCTGGGCGCAGTGGCTTACGCCTGTAATCCCAGCACTTTGGGAGGCTGAA

[0527] GCGGACGGATCACGAGGTCAAGAGATCAAGACCATCCTGGCCAATATGGTGAAATCCTGTCTCTACT

[0528] AAAAATACAGAAAATTAGCTGGGCATGGTGGTGTGCACCTGTAGTCCCAGCTACTTGGGAGGCTGA

[0529] GGCAGGAGAATCACTTGAACCCAGGAGGCGGAGGTTGCAGTGAGCCGAGATCATGCTACTGCACTC

[0530] GAGCCTGGTGACAAAGTGAGACTCCATCTCAAAAAAAAAAAAAAAAAAAAATTTACAATCAGTTTTTC

[0531] AAGTTCCATGGGGGAAAAATTATTTTTGGAATTTTGTTTATTGCACTACACTGAATTTATTTGTGGAAA

[0532] ATTGACATCATTATAATATTGAATCTTCCCATAAAAGGATATTTATGTAGGTCTTTGTCAAGTGAAGGG

[0533] GAACACATCTGCATGCACACATACATGTCATTTGGTGTAATGTGAAATAAGGTTTAGTGGAGAAAAAT

[0534] AAAGAAGTATTAAGGCACACACAATTCCCTAAGGTCTGTTATCCCCATATAGATGTGTGCACTGGCCA

[0535] GACACATCTAGAACTATGTACTGTGGAAAGGGCTCCTGTGTAATAATTGGAGCTTTGAGGTTGGTGA

[0536] AATGGTCTTACTAGGGAAAGCCATCAGTACTCTGTGGCTGATCAGCCTTTTCTTGCATGAAACAAACT

[0537] CAGACCTCCTGAGCCAACTTTTTGATAAGCTACCAAAACAGGGGTGGAAACCTCTAGAGTCATCTGA

[0538] CTCTGTCTCTCTTCTTAGTAGCCTTTTGTGCACCTGCACATTATTTTGTTGTTTCCGTCACAAAAGTTT

[0539] TGGGAATCTTTTGTTAGACTTTTCTTCTAGATTCTTTATAATGTTACTATCATGAGAAGCATCTTTTTTT

[0540] AATTGGCTCTGGCTAATGTGTTAGAACACCATGTAATTTTATGTCCTTGATTTTATATCCAACAAACCT

[0541] TGCTAAACTCTTCTGTTAGTTTTTATAGTTAATAGGTATTAGCCCTGATGGTTTGTAGATTCTCTTGGG

[0542] TTTTTCTGTAGATAGCATGTTTCCTACAAATAAGTTTTTTGTCTCTATAATTCTAATTCTTATGCCTCTT

[0543] TATATAAATATATATTTATATAAACACTTATATAAACACTACCTATACTACCAAGATTCAATGATTGTTA

[0544] ACATTTTACTGTGTGTATATCTCCTAAGAAAAAGGAAATTATTTCATTTAACCAAAATATCATATGTAG

[0545] GAAGGTTAAAATTCTATCATCTTACATCTGATATGTGTTCAGATTTCCATGGTTGTCCCAAGAATGTCT

[0546] CTTGCAGCTATCTTCCATCCCTAAACTAAGATCCACTCTGCATGCACTGAATTATTTGTTGACTTTTAG

[0547] TAGTAGTTATCTTTTAGTCTTAAACTGACCACCTACTGTTTTGTTCTCCCATGAAATGATTTATTAAAGA

[0548] ATCCAGGACAGTTGTCTTAGAATGTCCCACATTTTGGATTAGTCCAATTGCCAAGGCTTTGACTTTCA

[0549] AAGAGAAGAAAAATGTCTTAGAGAATGTTCCACAATCTATATTTGATTATTTCAGTGTAGCAGTCTTAG

[0550] CGTATTTCTCTATTCCCTGTGTTTCTTCTAAACCAGAAGTTAAGTATGAAGGCTTGATTAGATTCAGTT

[0551] TAAATGTTTTGCATGTATACTTCATGGGTGATGTCTCATGTTGTATCACATCAAGAGGCATATGTTGG

[0552] GTTGTTCCACTATTAATGATTCTAAGCCACTTGAAGGTATGTTTTCCCCTTCATCTTTAATCTGTGGCG AAATACTTTGGCACTATGTAAGTATCCTGTTCTCCATCAGCTTTTCTCCTAATGATTTTTAGCATCATTT GATCCTTTCCTGAACCAATTATTTTATATTAGCTGGCATTCTTTTGTAAAGAAGCATTTCCCCATATCA AGTGGGAATAACTAATTTTTCCTAAAAAGGCGGGATACATGCATAATTTTTTTCATTTAAAGTTCAGTT TTCTAAGGGTGTAATAATCCCCTACAGTGTGAGCAACTGCTCTCCCACCCTTTTAATTTTTATGGAATT TTGAAGGTTTTTTGTTTATTTGTTTGTTTTTGCATACCATCTGTTATAGTCAATTACAGTACTTATTCTTT TTGCTGAAAATCTCCAAATTTGGTCAGTAGGAGTCCCTTCAAGCTGGCCTCTGATGTTGTTCTGATAT CTGGCACAAGATGTTCCTAGATCTCTCTTCTTGAATAATAATAGATAGGTTTGAAATGCTGTAATGCT GGCCCTTTCCCCCATTAATGTAGTCATTGTGTTGTTGTTACTTTGTGTAATCTAATAATGCTTATTTTG TTAAGACCTAATATGCTTATTAATAAACTCATTAGTAAAACCTAAATGCTTATTTAGGTTTACTTTCATG TATATTAGTCTCTAGATTCTCCATCTGTGTTCATTTTCTATGGCTGCAATAATAAATAACAACAAACTT GGTCACTTACAACACCACAAATGTGGTGTACTCTCTTACATTTCTGGAGGTCGGAAATCCAGAATGA GTTTGTTTTACTGGGCAAAAATCAAGGTATCAGCAAGACTTTGCTCTCTCTAGAGACAATAAGGAAAA ATCTG ATTTCTTG CCTTTTCCAG CTCCTAG AGCTG CACTGCTTGTATTTCTTG G CTCATG GCCACCTC CTCCATCTTCAAGGTCAGCAGTGTAGCATCTTCAGATCTTTCTCTGCTGAGTTTTTATATCACCTAATC ATCTATAGTAAAATTCCCTTTTATTTCCCTCTTATAAGTATGCTTGTCGATTACATTTAGGGCTTACCC AGATATCCAGAATAATCTCCCTGTTTCACAATACTTAATCACATCTGCAAAGTTCCTTTTGCCACATAG GATAACATTTACAGGTTCTTCTGGGTCTTGGTATATGTTTAGTTATCTTGGTGGGGGGCCACTATTCA GCCCTCTCATGCCACTCTTTCTTTGATATTACTTCTTGATTCAGTTTCCTTTTTCTAGGTTGTCAGTTAT TTTCTTCTTGCACCTTAACGTCAGTTCATTATCTTCTTGCTTCTTTTACTGATGTTGAGAAGTATGCCA TCAGTCTGACTTGTCTTTACTTTCTGGTTGACTTTAAGAACTGAACTTTTTTATTTTCACCTGTTTTGGA AAATTTATGGCCAGCTTCTGTTCAAATATCTCCCCATTCCCTGTTTACCTCCCAGATTAACTCATTTTG TGCTTCGTGTCTTTCATATTTTCCATTCATTTATCTCTGCCTTTTGGCTAATTTTCTCAGAATCACCTTC TAGTCCTTTAATTCTCTCTTCAGCAGTAATCTGTTTTACGTTACCTGAGGTTTTAATTTGATGACTGTA TGATTCAAAACTCATGTCTTTATAGTTTCCTCATGCTTCTTCTTTATATGTGTTGTCTTTAGGCTTGCTG TTCTTCCAGAGTTATCTCAGTAGAAATTTACTTTTGTGTTTTGGTCTGCAATTTATTAGCTTTGATTTCT TTGTCAAACTGATTATATTCGTTTTCTGTTTTTCAGGAATGTTCTGAATTTTTCCAACTAAGTGGTTGAT GGTCCTGGCCTCCTTGCTTTCAGTACTGTGATTCTTTCAACCATTTTCTTGAAATTTTAAGACCACTTC TGTCTCTCCCTTCCCTCCCTCTGTTCCTCCCCCAACCCCACCTTTCGTAACAATTATTTGTTTCTTGG AATCTCTTAGGCTAGTCCTGTAGTTTTCCCCTTTGACCTATTAAGTATTATGTTACTGGATTCCTAATT AATGATTATTCTTGCTTTTAATATATATATTTATATATACTATTATATATGTTTATATATCATATATATTAA TTTAAGAGTTTGATGCCTTTCTTCACAGTTTGGATTATTTTATGTTTTGTTTGTTTGTTTGTTTAGAGAT AGTCTTGCTCTGTTGCCCAAGCTGGAGTATAGTGGCGTGATCTCAGCTCACTGCACCCTCCATCTCC

[0553] CAAGTTCAAGAGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCACGCACCCACACC TAGCTAATTTTTGTACTTTTAGTAGAGAAAGGGTTTTGCCTTGTTGGCCAGGCTGGTCTCAAACTCCT GGCCTCAGGTTATCCACCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGAATGAGCCATTGTAC GTGGCCTATTTTTTTTTATGTTATCTTTGTTGAGTTTTGACATCTAGGTTTTGCTAGCTTCTTAAAGTAA TTTAGAAGATATATAAGTATATATATGAATATATATATAAAATCACCTGTTACTAATTGATATTTTAATTA CATTTTCTTTAAGGGATGAGGGGAGCCAATGGCTGTAGTTTTTTTTTTGTGCCATAGCTCCCCTTCAT GTCCTTCCATAGCAGTTTGTCTGCATTTATATTTTAACATGGGCATCTTCTAGGATTTTTTAAAAAAAA TTCTCAGTCTTTTTTTTGGAGAAGGAGTTTTGCCATTTGTAAAGTCACTAAAAATGATCAGTTATTTAC TAAGCTTGCTTGGCTGTAATAGCTGTGGTCTACTGAAGAGATTAAAACAGGAGAGGAGATCTTTTAGT AACTTTCTTGAAGTTTTTAGTTTTGTTTTTAATTTTTTCATCTCCCTTTTAGGATTGTGGTAACAGGTTT TTCTTTTTTTTCCAAGAAGATGTTTTAACTATGTACCTACCGTTAGCTTTTCAGTATCTTATTCTACTTT TTAATATATCTCTATTTTATAAGAGTCATCAAAGTTCTTTCTCTGACTCTTCTGGAGATTCTGAAAGACT TTCTCTCCCAAACACATTCTTTAAAATTCCAACAAGGGTCATTGTGACTTTTTTTTATTCTTCGGATATA AAATTACTCTTCTTTGGGGAGATAAAAAACCTGACTTCCAGACACTTATGGTCTGGCCCCACTATACC TAGCCAATATTATCATTTTCTTTTACTTTTTTTTTGAGACGAAGTCTTGCTCTTGTCACCCAGGCTGGA GTGCAGTGGCGCAGTCTCGGCTCACTGCAACCTCCGCCTCCTGGGTTCCAGTGATTCTCCTGCCTC AGCCTCCTGGGTAGCTGGGATTACAGGCACACGCCACCACGCCCGGCTAATTTTTGTATTTTTAGTA GAGACGGGGTTTCACCGTGTTGGCCAGCTGGTCTCGAACTCCTGACCTCAAGTGATCCACCCGCCT CATCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCACTCCCAGCCCAATCTTAACCGTTTTTT ATACCCCAGCAAGAAAATTTTATTCTAATCAGCTCATTCTCTTCATTTCTCATCTCTGATTATTTTCCCC CACTTTCTCTCTCCCATCCTTTGAGAGAAATAGTTCTTTATGCTAACTGCATATGAGTTTTTATGGAAC ATTGAAAAAAAAAAGGGAGTGTGGGTAATATTGTCCTGAATTTACTGGACCTAAGAAAGAATCACTGA ACTAGGATGACCTGTTTTCTTTCCTACCCTATTCTGAAACCAGCTTAAATCTTCAGCTTTAATTGCATA CCTATTATGACTAAGACACCAAAATAAATCATGAGGGGACAAAAAAAGAAAATGTTTCTGATCTTAAA GTAGCTAATAGACATGGAAAACATAATCAACTTTATGTTATCAAATTATGACTTAGAAAACAGTTTTGC CGAGTTGATCAGTGAACACATCATAGAGGGATGCTCTAAGGAAAGATCCATCCTGGACAATGTGGCA AAACCCCATCTCTACTAAAAATACAAAAATTAGCCAGGTGTGCTGCTGCGTGCCTGTAGTCCCAACTA CTTGGGAGTCTGGGGTGGGAGGATTGATGCCAGGGAGGCTGAAGCTGCAGTAAACCAAGATTGTG CCACTGCACTCCAGCCTGGGAGACGGAGACCCTGTTTTAAAAATAAATAAAGTATTCATTTTTTTTTA AACAAATATATGTTTGCTTATTGTATGCTAGGCACTGTTCTAGGCTCTGGGGATAAATCAGAAAAAAT AAGACAAAAACCTATGCCCTCCTGGACTTCATTCTGTTGGGGAGTGGGAAGACACACACCAATAACA AAATGAACACGTAAAATATATATAGTAAGGTGGTCACATATGCTACGGAACAAATAAAATTAACAAAG

[0554] GGCATAGAAGCTGATTCTGTGCCTTTAAGGAATGGGAGGGATAGAGCCTTTCTAAATGAGAAGGTAA G AG AATG CTTCATTG ATAAG GTG ACATTG GG ATAAAG AG ATG AATG AACTTG GTAAG ACAG CAAACT TTATAG AAATCTTAG GGG AAG AG CATTCCAGG CAG AAG G AATAGTAAATTC AC AAGTCCTG CACTG G GAGTATACTTGGCACGTTCAGTTAGGCCAAATGTGATTGGAATGGGATGAGTGACGGGAGAACAATA AGAAATGAAGCTAGACAAATAGCAGAGGGCCAGGTCATGGCTTTGGTGATTTTTAGTGGGGAAGCC AGTGGAGGGTTTTGAGCAAGAGAATGACATGTGATCTGCAGTTATAGTTTTGTTTTTGAGATGGGGTT CACTCTGTTGCCTAGGTTGGGGTGGCGCGATCACAGCTCATTGCAGCCTCAACTTCCCAGGCTCAA GCAATCCTCCCACCTCAGCCTCTGGGACCACAGGCACACACCACCACGTCTGGCTATTTTTTTTTTTT CTTTTTTTTTTGTAGATACAGGGTCCTACTATGTTGCGATCCTCCCGTCTCAGCCTCCCAAAGTGCTG AGATTACAGGCGTGAGCCACCATGCATGGCCTGCAGTTACAGTTTTTGAAGAATAGCTACTGTGCCA TTCTAGGCATGAAATAGGAGAGGCCATTTCAGAAACTCTTGTTAATAAACTAACAGAGAAATGAAGGT GGCTTAGACCAGGGTGGTAAAGTTAGAGAAGGTGACTAATATCTACATATATTTTGATTTGGAGATGG ATTGAAATGGATTGTCAGATGTGAGAAAAGAGTCAAGGATGATGCTGAAGTTTTTGGTTTACTCAAAG AAGGGAGCTTATTTCCTGAGGTAAAGAGACTAGGAAAAACAAGTTTTGTGGGGGTGATGGGGGAGA TCAGAAGTTAGTCTTTGAACATGTTAAGTTTGAAATGCCTATTAGGTATACTAGTAGACATATTCAGCA GGCAGTTAGGAATCTGGTGTTGAGAGGAAAAGGTAGAGTTGGATTTTAAATTTTGGGCTTCATCAGT TCATAGTTGGCATATAAAGATACAAGATTGGATGAGATCACCTAGGGAGTAAGTGTAGCTTGACAAAA GAAGCCATCTGACACTTTTTGGAGATATGAAAAATTAGCAAAGGCATCATGAAAGAAAACATTGAAAT ACCTGACTGGAAAAACAATTTGGAACCTCTATCACTGCTTCTCAGACTTTAATATGCATATGAATCATT TTGTTAAAGTTCAGTAGATCTGAGATGGAGCTTGAGCTTCTGCTGTGTGTTTTGTTTGTTTGTTTGGTT TTTGGTTTTTTTTTTTTTTTGGCAGGTTGTGGGGTGGCGGTAGAAACTGAGTCTCACTATGTTGCCCA GGCCGGAGTGTAGTGGTGCACTCATGGCTCACCGCAGCCTCAACCTCCTGGGCTCAGGTAATCCTC CCACATCAGCCTTCTGAGTACCTGGGACTACAGGCATGCACCACCATGCCCGGCTAATTTTTGTATT TTTTATGGAGATGGGGTTTTGCTATGTTGCCCAGGCTGGTTGTGAACTCCTGGGCTCAAGCAATCCA CCTGCCTCGGCCTCCCAGAGTGTTGGGATTACAGATGTGAGCCACTATGCTAGGCCAGCTTCTGCT GTTCTCACAGTCTTTC AG AAG ATG CTG CTG CTTCTG GTCTGTG G ACCCAC ACTTTG AGTAGCAAG AC TTTATATGACAAGAGTCATGAAAAACAATTGAAAGACCTTAACATTTGTAGAAGAATAAAGATTAATAT CCAGAATAAAGACTATCTATAAATGAATATGGAAAAAACAAACAACTCAATAGAATAAAAGGGAGTGC AGTATAGGGAATTTTCCAAAATCTCAAATGGCCAGTAAGCATAAAAAGTGCTCAACTTTGTAAGAAAT ACAAATTAAAACATGATTGCCTTTTCCCTTTCAGACTGGCAAAAGTTTAGAAGTGTGATTGTGCTGGG TGTTGGTGAGATTGTGGGGAAGAGTGGACTTATACCCTGCAGATAGGGACTTGACTTGATACATTTC TTCTTTTGGAAGACCATTTGGCATATTTATTAAATTTTAAAATAGGTATATCCTTCAATCCTGGAATCCT ATACCTAG ATACCAAAAAATAAAACTTG CACTTTTACTCTG AAAAG CAGTTCAG AACTATTTGTTG GAG TATTGTTTGATGTTGAGGAAATGGAATAATCTAAATGTCCTTTAGTAAGGAAATTATTAAATCAAGAGA TTTGGAACTCTTTTTTTTCATTTATTTCCCAGTACATTTAAAAATTGATATCTGACATTTTTTCATTATAA CTTTGAATAGTTTAAAAGGCCATAATTTCTACTGTGTGTTATATTTATGTTAAATACATTTTTTGGACAA GCCTTAAAGCTGCAGATTTAGATCATTCAACTTAGAAACAGAATCTTCCGTATAACCTAATAGCCAGT TCTCACTATCAAACCAGACAAATTGGACTGTTTTTCTTTTTTATTAAGAAAAAAAACCTGATTACTTATT TATCTTAAAACAGATATACTAATATATGCCTTTTAATAACCACTAAACTTCTGGATTCTAGTCTGGCTG GCTGGTGATGGGTAAGGCTTGGAGCCTTGCCACAAATTTGTTTCATTGATAAAATATGGTCCTGCTCT TAATTTTTCCCCCTTTTCTCTCAAGGAATTTCCCTATTTAATTGTCTATTTGTTAGGTACTTTGGAATTT ATACGTCTCAGAATGGTGCATCTTAGTAGTATTTGAGGTGGAAAAGAACTTTGCCTTTCTTTTATAAA GTGGAAAATAATTATTTTAAAAGAGGAAGTAGACAAGGAGAACCAGTTCTTAAGCAGATCAATCAGG

[0555] GAGCATACAGATAAAACTTGAGGATCTGGAAATTCTCTTAAAATTGTCTATGCCCACCTAACCCCTGG ATACCACTGAAGTTTAGAGACTGTTGAAATAAGCAGTGCAATGCTATGAAATGAATGCTATATAACCA TTAGGGAGTAAAATATATGCATATTGACGTGGAGAGACTTCTGAGACATTACTCCATGAAAAAAGCAA GTGTTAAAAGTATTTTATATATAGTATTTAATTATATGTGTACATTTCATATATGTATGTCTTAATGTTTT TTCCATGAGTAAAAGGGAGACATGGAAGGCTGCTCACCAAACCATAAACAGAACTTAACCTTTTTGAA AGGGGGCCTGGGAATGTGAGGAAGATGAAGAGAGATTTCATGGTTTATTCTGAATATTCATGTATTC TTTGAATCTTTTATAGTTGAGAATACGTTGTATTACTAGTGTAGAAAAAAATTTAAAGATGTTTCATAAT AAAAGAGAAAAACCACTGTACTAAATGATCTCTAAGCTCAAAATTTGAGGAACACTGGCAGTTACTGT GATGTAGTTGTCTATGTTAAAATATTTCTAATTCATATACTAAGTGATTTTTATTTAAATTCTTTTGAAAT ATTTTTTAGGTGTGGAATATCAAACAAATGATTAAGTTGACACAGGAACATATAGAGGCCCTATTGGA CAAATTTGGTGGGGAGCATAATCCACCATCAATATATCTGGAGGTAAGCTTTTGAGTATCATATCTAG

[0556] TAATTTTGAAAAGAAAAAAAATGAACTTATAAAAACATTTGTACTGATAATCTTGATTATTTTAGGAGGT

[0557] GGGATTAGGAATAGATTTGGGAAGAGAGAATTAGCTTTGCCTGTATTATACTTCTTAATCTTGTTTTGT

[0558] GTCACTTGTTAAAATAAACATGTATTTTATAATTTAGAAAACATCAGAACTAAGGGGGAAGTGATATAA

[0559] ATTTCAAGGTATTACTCTGAATTAAATTTTTATTTTTATTTTTATTTTATTTATTTATTTTTTTTTGAGACG

[0560] GAGTCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGACACAATCTCAGCTCACTACAACCTCCGCCT

[0561] CCCAGCTTCAGACGATTGTCCTGCCTCAGCCTCCTGAGCAGCTGGGACTACAGGCGCACATTACCA

[0562] CGTCCACCTAATTTTTTCTATTTTTAGTAGAGATGGGGTTTCACCATATTGGCCAGGCTGGTCTCGAA

[0563] CTGACTTTGTGATCCACCCACTTGGCCTCCCAAAGTGCTAGGATTACAGGTGTGAGCCACTGTGCCT

[0564] AGCCAATTTTTTTTTTTTTTTTTTAAAGAGAAAGCACACAGTTTTGGAGCTCAGCAAACCAGTTACCAT

[0565] ATTGGAAAATGGGGTAATTTTTTAAAATATTTTTTCCAGAATGAGTTTCCCCAAAATTGGTTTCTGCTT

[0566] CCTTATAGGTAAAATTTGTAATTTTTAAATAGCTCAACATTGTTTAGCTTTACTGTTTAATAATGCCTTG

[0567] AGGTTTGTGTCAAGCCTTGAGCATAATTGTAAATTTATATTCATTAATCCTATGAGTTAGTAGGTGCTG

[0568] TTATAATCACAGATGAGCTTTCTTAGCATTAGTTTTCTTAAGTAGTCAGTCAGACTCCACAGCCAACAA

[0569] GGTGTTACAGAATCTAGGTGGTAAGGCTCTACAGCCCACACTGCTCACTACTACCCTACACACCCTT

[0570] TCTTTATAAAAGCTGGCTCAGCTGTCATCACTAGTGAGGCAAGGAGATGGAGAACTCTAAATTAGAA

[0571] ATGATCAGGTTGCCATTTGGCTCCAAATACCAGAGATTTTTAAGCACAGATTGAAAGACTTCTGAACT

[0572] AAATTTGTAACTTAGTAATTTAATTACTTTTTGAAGGGCCAGTTAAGTCTTAAGGATTTTATGAGAAAG

[0573] TTAAGTTTATATTTCTGAAGTAAACTTGGAAGTTTGGAAATAACAGCTAATATGCTGTTTTCTTTCTCCT

[0574] CTTCTTCATGTGGCTCATCCCAGATCACACTCCTAGTTAATATCAAAGCTAGGACTAGAATTCTTATTT

[0575] CTCATTACTAGTTAGTGTACTTCCTAATAGCCTGTGCTATCTTCTATACATATATTATTAGGAGGCTGA

[0576] TCAAAGGTGTCATAAGGAAGCAAGTACTGCTAATGAGAATGGCAATTTTTTATTAATCAGAATTAGAC

[0577] AATATAACCAGCAGTTTTTCTTCCAACCATTTCTATGTCTTGGAGACTTTGAACCCATGCTGAGATGTA

[0578] ATTCATTTGCATCAATAGCTATGTCCCCACTATAGCAGTGATTCACTGCCCCCTCCTCACATAACTCT

[0579] TCAGGCTTTTTACTATTTGAAGACTGATCACTAACAACAAACCTTAGAGCTTCTTATTCTGTGCCCAGT

[0580] ACTGTGTTAAATGTATTTTATTGCTTAACTCATTTCTTATAGTTACTTTGAGCAAGATACTAGGTACTG

[0581] GATATTTTTGTTATTCCCATTTTACAAGTGAAAAAACAGAGAGGTTAAGTAACTTAACTAAGGTGACAC

[0582] TGCTAGTTAGGAAAGAAGGCAGATATCTAAGTCAGAAATCTGTGTTCTTGATCTCTATCTTATTCTAC

[0583] CTTTATCATGACATTGTCTCGCTCTTTCCCCACCCTCACCCCCCAGACAGCTTTTCTTATTTGGGCTA

[0584] AATATTTCTATTCCCTTCAGCCATTCTTAGTAACATAATTTATGGACCTTTTATTAGATACAGTCTTTTT

[0585] GGTTGGTTCTTTTAGAATTAGACACACAAAATTGAACTACTTATTAAAATTAAATCTGAGTAGGACAGC

[0586] ATACATCAGACCATAACTCACAGGTTATATTATTAGCTTGTGGTAAAACAGATTCTTATCTTGGGGACT

[0587] TGTGGTATACAATGTGTGTGTATTATGTGTATGTAGTATGCAAAGGTATGCATATACACATGTACATA

[0588] CACACACACTGAAGGCAGCAGTATAATATAATAATTACGATGAGCCATGGAGTCATACAGACTCCAT

[0589] GTTTGAATCCCAACTCTGGCTTAGTTTCTGTACTCAAGATATCCAGCCTTCTTATACCCCACCTCATTA

[0590] GTAAAGTGGAAATAATATCACATCTTGGGTAAGTTAAGGATTAATTGAGTTTATAATTATGAAATAACA

[0591] TAGTTCCTGATTCAAATATTAAGAATTCTATAAATAGTTGATTTATCTTGTACTGCTCTAGGCCTTGGG

[0592] GAATAGCAATTGTCTGTCTTTTTTTTTTTCCTCCTGAGATGGAATCTTGCTGTCTCCCGGGCTGGAGT

[0593] GCAGTGGCACGATCTTGGCTCACTGCAACCTCCACCTCCCAGGTTCAAGCAATTTTCCTACCTCAGC CTCCCAAGTAGCTGGGATTACAGGCATGCACCACCATACCCAGCTAATTTTTGTGTTTTTAGTAGAGA CAGGGTTTCAGCATGTTGGCCAGTCTGGTCTCAAACTCCTGACCTCAGGTGATCTGCCCCCCTTGG CCTCTCACAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCTGGCCGGGAATAGCAATTTTTTAAAA AATGGCCAACAATCTCCGCCTTTTTAAGCTTATATTTTAATGAGGGGATGGATATATAGACAATGAAC ATATAAATGAGTTTTAGAACATTGCACTTATCACCATTTTATTTTTTTATTTTTTGTTGAGATGGAGTCT CGCTCTGTTGCCCAGTCTGGCATGCAGTAGCACGATCTCAGCTCACTGCAGCCTCCTCTCCTGGGT TCAAGTGATTCTCCTGCGTCAGCCTCTCAAGTAGCTGGGATTACAGGTGTGCGTTATGACTCCCGAC TAATTTTTGTATTTTTAGTGGAGACAGGTTTCACCATGTTGGCCAGGCTTGTCTCAAACTCCTGACCT GAAGTCATCCACCTGCCTCGGCCTCCCTAAGTGCTAGGATTATAGGCGTGAGCCACCGTGCCTGGC CATCACCATTTTATATACTATGAATGGACTCTAACCAGCCCAAGAGAAAAGACCTGTACATACTGATA TTTAAAGGCCCATCAGTGAAGAGCTAGATCTACTGATTACTCACTGAGACCCACCGTTCTGCAGGTT TCTCATCTGCCATTTAAGATTCCTTTACACTTTTTTTTTTTATTGGGGTAAAATATGCCTAACAAAATTT ACCATTTTAACCATTTTTAAGTATATGGTTCTGTGGCATTAAGTCCATTCATGTTTTTGTGTATCCTTCA CCACCATCCATTTCTAGAAATTTTATCATCCAAAACTGAAACTCTCTAGCCTTTAAACACTAAATCTCT ATTTCCTTCTTTCTCTAGTTCGTAGCAACCACCATTCTACTTTCTATCTCTATGATCTATGAATTGGAC

[0594] TACTCTAGGAACTTCATGTTAATGGAATCATATAATATTTGTCCTTTTGTGACTGGCTTATTTCATTTAG CTTAATGTCTTTGAGGTTTATCCATGTTGCAACAAGGATAATGCATATATCAAAATTTTTTTCCTTTTTA AGGCTGAATAATAATCCATTCATTGTATGTATTTACCATATTTTGATTATCCATTCATCCATCAGTGGA CACTTGGGTTGCTTCTACGTTTTGGCTATTATCAATAATGCTGTGAACATGGGTGTACGAGTATCTGA GTTCCTTTTACTTCTTTGGGGTATATACCAGGAGTAGAATTGCAGGATCACATGGTGATTTTATGATT ATTTTTTCTG G AGTTG CCACACCTTTTTCTGTAG CACCTG CCCTGTTTTATATTCCTACTG GCATCG CA TGGGGTTCTAATTTTTTACATCCTTACCAACACTTATTATTTTCGGTTGATTAAAAAAACCATAGCCTA GGCTGAGCGCGGTGGCTCACACCTGTAATGCCAGCACTTTGGGAGGCTAAGGTGGGCGGATCACG AGGTCAGGAGTTTGAGACCAGCCTGACTAACATGATGAAATCCTGTCTCTACTAAAAAATACAAAAAT TTCAGGTGTGTGTAGTGGTGCGCACCTGTAATCCCAGCAATTCAGGAGGCTGAGGCAGGAGAATCG CTTGAATCCAGGAGAAGAGGTTGCAGTGAGCCGAGATCATGCCACTGCACTCCAACCTGGGGGACA G AATAAG ACTCCGTCTCAAAC AAAAC AAAACAAG G CAAAACAAAAAAAACATAG CCTCATGTG CGTG AAGTGATACCTTATTATGGTGCTGATTTGCATTTTCCTGATGACTAACAATGTTGAGCCTTTTATTATG TGCTTATTGGCCATTTGTATATCTTTTTTGAGAAATGTCTGATTTAAGTTCTTGGTCCATTTTTTAATTG

[0595] GATTGTTTGTTTTGTTCTTGTTATTGAGCGTAGTTCTTTATATAGTCTAGATATCAGTTCTTATTGGATA TTTAATTTGCAAATATTTTTCCCATTGTGTGGGTTCCCTTTTTACTCTGCTTATAGTTTTTTAGTCCAAA TTATCTATTTTTCTTTTTGTTGCTCTTGCCTTTGATATCATATCCAAGAAATCATCACCAAATCCAATGC CATGACATTCTTCTCCCAAATGCTCTTGCATTTGGGTCTTTGATCCATTTTGAGTTAATTTTTATATGAT GTAAGGTAAGGGTCCAACTTCGTTCTTTTGCATATGGATACCCAGTTTTCTCAGCATCATTTGTGGAA AAGACTGAATGGCCTTGGCACCCTTGTCGAAAACCATTTGACTATATATGCAAGAGTTTATTTCTGGG CTTTCTATTCCATTGGTCTATATGTCTGTCTTTATGCTGTCATCATACTGTTTTGATTACACTAGCTTTG TGTAGTAAGTTTTGAAATCAGGAAATGTGAGTTCTCCAACTTTGTTCTTTTTCAAAATTGTTTTGGCTA TTCAGGATCCCTTGAGATTCCTTTTTTTTTTTTGAGATGGAGTCTCACTTTGTCACCCAGGCTGGAGT GCAGTGGTGTGATCTTGGCTCACTGCAGCCCACCTCCCAGGTTCAAGTGATTCTCGTGCCTCAGCC TCCTG AGTAG CTG GG ATTACAGG CACCTG CC ACCATG CCTACCTTTTGTATTTTTAGTGG AG ACG G A

[0596] GTTTCACCATGTTGACCAGGCCAATCTCGAACTCCTGACCTCAAGTGATCCACCTGCCTTGGCTTCC

[0597] CAAAGTGGTGGGATTACAGGTGCAAGCCACTGTGCTCAGCCTCCATGTGAATTTTATAAAGGATGTT

[0598] TCTCTTTCTACAAGTAGGTCATCAGGATTTTGATAGGGATTGGATTGAATCTGTAGATTGCTTTGGTT

[0599] AATACTGATATCTTAAGAATTCTTAACTCTGAAATATGAGTGGACAGTTAAGAATAACCAGATATTTAA

[0600] AGAAAGCTGTCAACAGGAAAGACAGCAGCAGAAATGGTCAACAGAAACTCAGAAACAGTGCAGAAA

[0601] ACAGAATAAAACTTAAAAATAACTATAATTAGCATCAGAGATAAGATCTATTAGTCCTGTCTTGCTTTG

[0602] TAGCAATACTAAAGAAGCAAAAGTAACAGAGAACAAGAAAGACCTCTTGGAAATTAAAAATACAATAG

[0603] CCAGAAATTTATTTTTATTTTTATTTTTTTTTAATTTTCTTTTTAATTCTCAGCAAGGCAAGTTACGTCTA

[0604] TAGAAGGGTGCGCCCTTACAGATGGAGCAATGGTGAGCGCACACTTGGACAAGGGAGGGGAAGGG

[0605] GTTCTTATCCCATATGCATGTGGCTCTTGCTGCTGTGTCATTCCCCTGTTGGCTAGGGTTAGACTGC

[0606] ACAGGCTAAACTAATTCCGATTAATAACTAGAATTTTTTAATTTTTATTATTATTTTTCTTTTTTTGAGAT

[0607] GGAGTCTTGCTCTGTCACCCAGGCGGGAGTGCAGTGGTGCGATCTCGGCTCACTTCAAGCTCCACC

[0608] TCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCGCCCGCCACC

[0609] ACGCCCATCTAATTTTGTTTTTGTATTTTTAGTAGAGACTGGGTTTCACCGTGTTAGCCAAGATGGTC

[0610] TCGATCTCCTGACCTCGTGATCCGCCCGCCTCAGCCTCCCAAAGTGCTGGGATTATAGGCATGAGC

[0611] CACTGTGCCCAGCCCAGAAATTTTTAAAAATATATGTATATACAGACATATAGGTATGTACATGTGTAT

[0612] ATATGTATGTGTTGTATATATATAAATAAATGTTGAAAAATAAATATTGGAAGATAAATGTTCTAGAAAG

[0613] CAGAGTAAAAGCAGAGAGATGGGAAATTTTAGAGGAAACATGAGAAAAATTAAGGAATAAATCCCAA

[0614] TCCATAAAAATTATAAATGCGTTTAACTGCAAGAAACAGAACCCTTCAAGAATAAGTTTCTGGAACAAA

[0615] TAGGGATTTTCATTTCCTTTCACATAGCAAGAAGCGTAGAGGTAAATTATTGTAAGACTAGTTCTACA

[0616] CAGGTCAGTTGTCAGATACTTGGTTGAATCGCTATAGTCCCTTTAGCTTTTCTGTCAAGACCACAGCA

[0617] GATTTTTAAGATCTTTCCCTCATACAACTCCTCAAAGCAGAAAGCAGAGAACAGAGAAGTTCTCTTGT

[0618] ATACTAAGCTCTTGCTAGGAAGAAAATCTTTCTCAAAAATCCTCTATAACTCTTCCTTTTATATCTCATT

[0619] GACTAGAATGAGGTCACATATCACCCCTATACTAGTGACTATGCTTACATTTCCTGAAGTAAGAGTCT

[0620] AATAAGTCAAAAATTTCCAGTGTTCAGTTTTTCTTCAGATTAGTTTGTATGCTGTCAAGTAGAAGTTGT

[0621] GCTATGATTATTTTATTCTATAACATTTCAACAGAAACCCCTTTTAAGTTTCTATAGGAAGATAAATCTT

[0622] CAACTACTTATTCTTGCTTCTTCTCTTCATTGTAGCAAAACAGAGAAATTGGTTACACCACCATCAGAA

[0623] ATCCTCTTGATTTTCTTTTTCCCACGTACTAATTTATTTAAAAGCCATCTTTTCAGTTCTAGATGTTCTC

[0624] CTACTGGCAGATAACAGTTAACATTCTATTGATTCCCTTGATGATAACTACAGTGAAATATGAGATACA

[0625] GTACTCTAAAGAATTTCAAATTTGTCTTCTCAGTTGATCTTTGGTTCCCTTTTTTCTACCATCATCCAAA

[0626] GGAAGAAAAGATAAATTTACTCTGAAAAGTTGTTCCCCAGAGTTTCTTCATTTCCTCTCAGTGTTTCCA

[0627] TATTCATTTATCCAACAAATTATTGGAATGCCTTCTATGTGTAAGATATAATGCTAGATGCTTTTCTAGT

[0628] AGTAGATTCTTCTTTCTGTACTTGATTTATTGGAGCCCAGAGATGAAGGGATACTGTCTCTGTAATCA

[0629] CCCTACAGCTGAGTCCTAACTACTTCAGAATTTATGGTTGAATCCTACAGTCCCCTGTAGACTGATGA

[0630] AGACAGTAACAGCTCCTGACATTTACTGAGTATTTACTATGTATCAGGTACTAATCATATATTAGTTCA

[0631] TTTAATCTTCAGCCTACCCTTTGAGTTACACTTAACTATTCTCATTTTCATTTTATAAATGAAGCAATTC

[0632] AGGCACAGAGGGATTTAATAATATGGCCAAGGTTACACAACTTGTAATTGGTAGCCAAGGTTTGAAT

[0633] CCCAGACATTCTGAATTTACAGCCCATGCGTTTAATCACCGTATCATTCTTACACTTGGCAGCCTTTC TGATTTTTAGTCTATATAGAACCTAGAATAATACAGAGGCATTGTGTCAAACCCTTCAATGAAATTAAT

[0634] ACTGGAAGCTGGATGCTTCCTGTGGAATGCAGAACAGTCCATTATATATCATTTATGGGCAGTTTGTA

[0635] AGATTTCATTGTATCTTGTGAGAGTAAGAATAATTAGACTAAATTTAATTAACTAAATGATAAAAAATAA

[0636] AATTTTTATTTCGCTGCTTTTTCTCATTACATTGAAATTAAATAGATCCTTAGATTTTTTTCCCTTCTGTT

[0637] TTAATTGAGAAATAATTCACATACTATACGATTAACTTTTTAAAACTGTGTAATTCAGTGGTTTTTACTA

[0638] TATTCACCACTATCTTATTCCAAAACATTTTTATCACTCCCCAAAAGAAACCCTTTATGCATTAGTAGT

[0639] CATTCCCTGCAGCCCCTGACAACCACTGATCTACTTTTTGCCTTTATGGATTTGCTGGTTGAAATATT

[0640] TCATATAAATAGAATTATATTATGTGGCCTTTTGTGACTGGCTGCTTTTACTTAATGTAATGTTTCCAAA

[0641] GTTTGTTTATGTAGTAGTATGTATCAGTACTTCATTTCTTGTTATGGCTGAATATTTCATCATACACATA

[0642] TATCATGTTTTGTTTATCCATTCATCAACTGATGAACATTTGGGCTACTTATATGTTTTTGCCATTATGA

[0643] ATAATGCCACCATGAACATTCACGTGCAAGTTTTTGTGTAGATATATTTTCATTTTTCCTGGCTGTATG

[0644] CCTAGGAATAGAATTGCTGGGTCTTGTGGTAACTCTGTTTTACACTTTGAGGAACTAACTGCCAGACA

[0645] GTTTTTCAAAGTTGCTGCACTATTTTGTATTCCTAACAGCAATGTATGAGGGTTACAGTTTCTCTCCAT

[0646] CCTCATCAACCCTTGTTATTATCTATTTGTTTTTTTAATTAAAGCCATCTTAGTAGGTGTGAATTGGTAT

[0647] TTCATTTGGTTTTGATTTGCAGTTTCCTAATGACTAATAATATAGAACATCTTTTCATGTTCTTGTTAGC

[0648] CATTTGTATATCTTCTTTGGAGAAATGTCTATTCAAATCCTTTGCCCACTTAAAAAAACTGGGTTTGTC

[0649] CTTTTATTACTGAGTTGTAAGAGTTCTTTAGGCCAGGCATGGTGGCTCACACCTGTAATCCCAGCACT

[0650] TTGGGAGGCTGAGGTGGATGGATCACTTGAGTCCAGGAGTTCGAGATCAGCCTAGGCAACATGGCG

[0651] AAACCCCGTCTCTACAAAAAATACAAAAATTATCCAGGCGTGGTGGTGCATGCCTGTAGTCCCACCT

[0652] GCCCGGGAGGCTGAGATGGGAGGATCGCTTGAGCCTGGGAGGCGGAAGTTGCAGTGAGCCAAGAT

[0653] GGCAGAGTCACCCAGGCTGGAATGCAGGGGCACCATCTCGACTGACTGCAACCTCTACCTCCTAGG

[0654] CTCAAGCCATCCTCCCACCTCAGCCTCCCGGGCAGCTGGGACTACAGGCATGCGTCACTGTGCCTG

[0655] GATAATTTTTGTATTTTTTGTAGAGATGGGGATTTGCCATGTTGCCCAGGCTGGTCTCGAACACCTGG

[0656] ACTCAAGCAATCCTCCCGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGTATGAGCCACCGCACCT

[0657] GGCCAGGAGTTCTTTATATATTCTAGATAGTAGATCCATGACTTGCAAATATTTTCTCCCATTCTGTGG

[0658] TATTTTTTCCCACTCTTTCAATTTTGTCTTTTGAAGTACAAAAGTTTAAATGTGGATGGAATTCCAATTT

[0659] ATCTATTTTAAAGTTTAAATGTGGATGGAATTCCAATTTATCTATTTTCTGTGGTTGCTGTGCTTTTGGT

[0660] GTATCATACATGAGAGACCATTGCCTAATCAAAGGTCAGGATGATTTACTCCTGTGTTTTTTTCCTAA

[0661] GAGTTTTATAGTATTAGTTATATAGCCAAAACAGGTTTAGTTGCTTGCTGCCTGCAGAGTCCAATTAG

[0662] TAAGAGCAAAGTCTAGTATAAAGTGACTTTTTTATTCCAAAGTTAGCTTAAAGGAAGAAGACGTACAG

[0663] GCTTCCTGCCTTAAGGGTACTGCTTCCCTGTTGGAGCAGAAAGTGGGTGCTTTTAAAGAAGGTGCCT

[0664] ACACGGGGGCAGAAATGAGCGGGTGGAAGATCTGCATATTCCCTTCGGTGCCTTCTTTCTCAGGCA

[0665] GTCAAGTTGGTGGCTTCATGGGCAAAAATACCTCAGAGGTGGCTGAAAACTCTAGCAGTCTTACTTT

[0666] TGGTTGTAGATCAACTATTACCTCTTGAGGCAACTTCCTGACGGGTGAGAGTTCCACTCAGGATTGT

[0667] CTAAGCACATAATTAGATCAACTTGCCTTGTAGGGAATGTCTGGTGAAAAGGAGATAAAAGGCCATA

[0668] ATTGCATTTCTTTTATTCTTTTATCTTTTTCTTTTTGAAACAGAATCTCATTCTGTCACTCAGGTTGGAG

[0669] TGTAGTGGCATGATCTCGGCTCATTGCAGCCTCTACCTCCTGGGCTCAGGCGATCCTCCCGCTTCA

[0670] GCCTCCTGGGTTGCTGGGACTATATGTGCATGCCACCATGCCCAGCCAAGTTTCATATTTTTTTTAGA

[0671] GATGGGGTTTCACCATGTTTCCCAGGCTAGCCTCAAACTCCTGGGCTCAAGTGATCTGCCTGCCTTG GCCTCCCAAAGTACTGGGATTACTGGTGTGAGCCACCACCCCTGGCATATAATTGCATTTCTAAAGA GCTAAGTAGGAAGTGGGGAGGAGGAGGAAAGAAAAAAATAATTAAACTTTTTCTTAGAAAAATGAGG GTGCTCAATTATATAATAGATATGTGACCCATTTTGTTTTGTTTTTAATTTTTGTAAAGATGGAGTCTAT GTTGCCCAGTCAGGTCTTGAACTCCTGGCCTCGAGTGATCCTCCAGCGTTGACCTCCCAAAGAGCT GGGATTGCAGGCGTGAGCCAACATGCCTGGCCTATTTCGAGTTAGTTTTTGGATATGTTGTGAGGTA GTAGCCCAACTTCATTCTTCTGTGTGTGGATATTCAGTTGTACCAGCGCCAGTTGTTGAAGAGACCAT TCTTTCTG CATTG AATTGTCTTG CTG GCTTTGTAAAAAAAAAAAATCAATTG ACTGTAAATGTAAG GTT TTATTTCTTGTTCTATTGAGAAATAATTCACATACTATATTATTCACTTTTTTAAAGTGTGTAATTCAGT GGTTCTTAGTGTATTTACACAATGGACAACTGTCACCACTATCTGATTCTAAAATATTTTTATCATTCC CACAAAGAAACCCTTCATGCATTGGAAGTCATTCCCTCCAGCCCCTGACAACCACTGATCTACTTTTT GCCTTTATGGATTTACTAGTTGTACCTTGTTCTATTCTGTTCTATATGTGTGTTCTTATTCCAAAATTAT TGCGCTGTCTTGATTACTATAGTTTTATAGTTAAGTTTTGGAATCAGGAAGTATAAGTCCTCCAACTTC TTTTTTCTTTTATAAGATTGTTTTGATAATTTCAAGTCCGTTGTATTTCCATATGAATTTTAAGATCAGC TTGTCAGTTTCTACAAAAAAAAATTGAGATTTTGAGAAGGATTGCATTGAATCTGTAGATCAACTTGG GAAGCGTTGTCATTTTAATGATATTAAGTCTTCTTAGATTCTTTTTTCTTTTTTGAGATGGAGTCTTGCT CTCGTTGCCAGGCTGGAGTGCAGTGGCGTGATCTCAACTCACTGCAACCTCCGCCTCCCAGGTTAT CAATTATTACTAATACAAATATTTATTGGATTTTTGCTATGTGGTAGTCTCTACAATAATTTGTTTTACT TGTGTTATCTCATTTAATCCTCACAAAATTATTTTGAAGTTGAGAAAAATTTGCCATATAAAGAAGAGT ATGATAAAATATTCTAAAGGAGATAAAGAGAAAGGATACCTCTTCTGGATTTTGACAAAGAGAGCTTA GAATTAGACTTTTTGAAAAATATTTAGAGTTTTGATGAGAAGGAATAGGGTTTTTGAACAACTGTCTCC TGAAGAAGTGGTATCTGGTATCTGCAGCATCTTGAATAACCAAAAGAAATGGTGGTGGTGGTTGTGG TTGAGGTTTGCACATATGTTGGAGTGGCTTGCTCATATTAGTAGAGTGAGAAAACAGAGGAAAAGGG AAAAGTAGATGATATGAGAGAAAACTGAGGGAATGGTAGACTAAGGCCCTAAACACCCAATATTAGC ACTGAAGTGAGAGTAGAAGAAGAATGGGGAAAGATGTGGAGAATTTTGTAGATAAAGAAGTAGAGTA AACTTTTCATTTGATGACTTTGATCTTCAGAGTGGATTTGAAGGTAATGTTATTTTCAGAGTGAATTAA AAGTTGAAGGATGAAGTTAAGATCCAGAGAAGAATTAGGAAGATTGGAATAACTGTTTTGACTGTAAT ATGATGTTAAAAACAAGCATGATTTTCAGGCAGTAGTGTGAAGGACCAGGCAAATCTAAGTTCCATAA ATTGATCATAGAACTAATTAGACCAGTTTTATTATTTTCTCCAACAGTGTGTGGTAACCTGACAGGAAA AAATAG AAC AATTG AATG GTCAG ACTTACCC AAAATTTGTATCTG G CAAG CTAGTTG ATAAAATAACA AGAATTAGCCTGAAAATCTTAAGATATCACCAATGGCATTGTTGTAGTTGTGAGCCGCAAAGTATGTG AAGGAAGACAACAATGGCCAAATCTTAGCAACTGTTTGAGAGATTAATGTTGACCTTGAACAGATTAA TGTAATGAGATAGACATTTAAGAAGTTGGGATAAGTATGTGTGCCCCAGGGGTGCGTGAGGTTCTAA ATCGAGATCATTTCATCATTTTTATTGCTTTTGTAAAGACTGTGATGCTTCTCCGGGTCTTAAAGGTAG AATGGAAATAAATGCTTTTAGAGGTGAGAGGTTTAGAGAAATCTATGGCAGTGTTAAAAGAGTAATTG

[0672] AAGTTCATATTGAATGCAGCAAGGGCAGTAGGTAAAATGAGCCAGGGGCCTTGGTAGATTGCAGCTT TGAGGATAGGGACAGATGGAATAAGTAGATGTTTTGTACTTAACAAAAGGAAAAGCTATTGATAGATG TGGTGAAGTGATAGTTTATAATCTGTCATGGAGGGATCAGTATACTTTCAAAAATTAAAGCTAACATTT TGGTAAGGAAATATGTTTGGAAAATTGTTCTTTTCATTACTTTTCCTAAGGTTTATTTTGTCTAGTAACT GTACTTGCTCAGGTGACAGTAAATAAGAATATTTTATCCATGCAGGAGGAACCTTTGTGTTCCAGACT GCATTTATGTGATCTTCAAAGAGTAGGAATTGTGTTTGTCTTATGTGTGGTTGTAGTCTGAGCCCTAA CAGTGCCAAGCACATGTATCAGTATATATTTACTGAGTGATTGAAGGCTCAATAAATAAATTTTATTGA GAGAAGTATGCTTAAGTAATTAGGCCTTGGTACTGAAAGCTAAACCAAATTGTAGCTCAGAAAATTTG GAATCTATCTGTTTATAATGCCCTCATCTACTATGAAACAGGGTCTGGGTAGGGCAACTAGCAGGCT GTAAACAAAGAAGACCTTTTGATGAAGTTTAAATCTCTTCCTCAGTAGCTCTTGTTACTATTCCCCGC CCCCCTTATTTGTTCGAAAGTATGTGGTAAGATGCAGCATAGCAGGGTCCTGTGGCCCTTATTGAAA TGAAATTTCTCTTTCATTCTCCTCTACATTTTATAATTCTCCCTTCCTCCCTTACATTCAGACTTGATAG CATGGCGTATATACTCTCTACAATCTATTCCCTTTCACCTTTTCAGCCTTATTGTTTCTTTACCTATTTT TCATTTAAATTTCTTTCTTTCCTTTTTAAG AAAAC AG G G ATG CTG CTAAAG CTTCATTTAAATTTCACAA ACATATATTGATCTTTTGCTATGTCCCAGGTATTGTATGACATTGAGCTATACCTATCTATAGTTTTTC ATGTGTCTTAAACTTTCTCGCCTTTGTTACAGAAAAAACAAACTCTTTGTTACAGAATTTTTCCCATATA GAGGATTCCTTCCTCCCTACTTTCTTCATCCATCTAAATGCCAACCTTTCAAGGCTGTCCTCCTTCCT CATTATTACTTTGTGTCAAGAATATTGTTTATTTCTCATGTACATCAGTTACACAAATAAAAATACACCC ATCCTACTCCACTGCCCAACAGTAAACTCCTTGAGAGACGGGAAAGGCCATTTTAAAATATTTGCTTC TCTCTTTCATAAATGTTTGTAGTATTGCATCTATTTGAGATGGTAGGTAGAAATAGTAGAGCATGGTGT GAGTGAGGGGATTACCAATGCCAAAAAGAACTATGGACTTGTATATTCCAATTCGTTCAATGTCATTC TGTTCTTTTAAAATTTGATATCTTGTATGGTTGCTTGACTTTATAGCCTTCATCAAATGAAACTTCTAGG AAGATACTCTGATGGATAGTAGCCCCATAATTTCTTGGCTGTAGGGTATAAGCCACATTTTCAAATAC AATTCTG TTTTTTTTTTTTCTTTTTTCAC AAG G CTTAC AG CTTTG C ATACTAGTTCC AATCTCTAAG C AG CATTAGGTGGGGAAAGAAGTCATCAAACAGCCATACTGAGAAGAGTAAAGTATTTTAACTGATAACTA TTCCAGAAAGAATGTGGCAGTTACACATCTTCTAAACCCTATTAAGGAGGTTTTGGTACTAACAGTGA GATCTGGTACTGTGTCCTAAATTTTGGGGTTTTTTTGGACAAATCCTTAATACCTCATGTCCTTTTCAA CTTCTTTTTCTGTTG AG AG AG AG AG AG AACG AATG G AATTCATATG CCTACAACTTTTCCG GG ACAAA ATAATTCTTTTAATGGGAGGAACACTTTTCCTTGATACAGTGTTTTATCTTACGTTAGACATGATTTGG AAGGTAAATATAAGTGGACCAGAAAATTGGAAATACTGTGCTTTTTTATTATTCATGGACCATCTAGAT ATCACATATGTATAGGTCAAATTTATCAGGTGTAATATAGTGTAGTGTCTAATAACAAAGAATTTATCA ATTTAAAGGTGAAAGTATTCATTTATAGTATTTCTGGCACTTATTTTGTAATTTGAAACTTAAAACCCTA TCAACTGGTGAAAAGATTATAATCAAAGGCTAAAATTTTATATTCTCTTTTGTTAATGTCAGGACAAAG TCCGGATTGAATATAAGTCTGCTTTATTTTATAGGCCTATGAAGAATACACCAGCAAGCTAGATGCAC TCCAACAAAGAGAACAACAGTTATTGGAATCTCTGGGGAACGGAACTGATTTTTCTGTTTCTAGCTCT GCATCAATGGATACCGTTACATCTTCTTCCTCTTCTAGCCTTTCAGTGCTACCTTCATCTCTTTCAGTT TTTCAAAATCCCACAGATGTGGCACGGAGCAACCCCAAGTCACCACAAAAACCTATCGTTAGAGTCT TCCTGCCCAACAAACAGAGGACAGTGGTGAGTCAGTTTTAATATCACCATTTTGCTGTTTCTTTGTAT TTTTCAGACAGATCAGTTGTTGAAAATTAATATATTATTACTTCATACTCAGAGGTCATGCAAATAGAG

[0673] GCATCCATGTC ATACAG G AATG AAAAATATGTAATTATTTG GTG G CAAAGTCTATATTCCTTAACTG AA ATAAATGGTATTGTCTCTAGTGTTGGATTTGACATTTAAACCTGTCTGCCAAACTTGAACCACAGTCAT GTCTAAGCACTAGTTTAAAATAAATCAGGATTTTAAGACTTGAGCTTGTTCATTATCTAATGTGTGTCA GGTAAGACTCATTCTTCACCCTTGAGAAATCTCCTTTCTGAGTTATATTATCAGATGTTGAACGTTCAG TGTGATTGATATGTTTCCCCTCATCTACTTCATTTTTGGTTGTTGAATATTAGTATTAACCATTGGAAC AGCGTACCCTGTAAGTAACATTTGAAGCATTTAAAGAGAAATCTGTGGAATTATTGTGGGTGGTCTAT AATCCTTAAGTGCAACGAATATTGTTAGTAGACTTAATAAGTAACCCATCTGTATACATCACTACTTTT TAAATGTCTGTGGTTACTTTTGACAATAAAAATTCCAAATACAACTGAAGTCAAAATTTTTCATTTTTTT TCTCTGACAACAGAAATCAAAAGTGCAATTGGTCATTGTTTAATGTTCCAAAAATTCCTTTCTGACTTG AAAAAAAAATGTTATTATAGAGGCATTTTACTTTCAGAAGTTAAGAATTCCTGCATATGAGTTTAGAAA ACTAATGGAGTTACGAGTTACCAGCCTGTAAGTTTTTATCTTAGGAAATATGGCTTTCTAAAGGCATC ATTTATTGTCAGGGAATAAAAAGTAATAAAATAAAAAGTCATACTTTTTCTGCCCTTTTTCCATGTACA GACAAAAGTTGGTTGTAAAAAATAGACTCTAATTTTTCATTGTACAGAATTACAAATCAATTTGTAAAA CAAATCCAGTTCTACCCTTTCTCTTTATTCTGTTGGGTAGAATAAAATTAAAATTATTTTTCCCACATTA AGATGGGGAATTACTAAGCATATCTTTCCAGGGATGCCCCACTTAAAAGGGGAATATCAACATATGA ATTATCTGTAAATAGATAATCTTCGAAGCAGCCTAACAAAACTGGCAAACATCCCATCCCCAGTAGAT CTTAAATTAATTCTTTATTGTCTGTATTCATGAGCAGAAAGTAGGAAATGTGTTCTTCAGTCCCAGGC GTTTCCCTTCTCTTCATCACGGTATTGTTCCTTCCAGGTTCCACTCAACTTAGTAATTTTGTGAGTTTC TGTATACAAATGTAAAATTGGGGTTGTTGGAGCCTTTCAAATTTCTCAACCTAATGATTAAGTTTAACT AGCCTCCGGCCGGGCACAGTGGCTCGTGCCTGTAATCCCAGCACTTTGGAAGGCTGAGGCGGGCA G ATCACG AG GTCAG G AG GTCAG G AG ATCG AG ACAGTCCTGG CTAAC ACACG GTG AAACCTTG GCTC TACTAAAAATACAAAAAGATTAGCGGGGCGTGGTGGTGGGTGCCTGTAGTCCCAGCTAATTTGGAG GCTGAGGCAGGATAGTGCTGTGAACCCGGGAGGCGGAGCTTGCAGTGAGCCGAGATCGCGCCACT GCACTCCAGCCTGGGCAACAGAGCGAGACTCCATCTCAAAAAAAAAAAAAAAAGGTTTAACTAGCCT CCTCATATTTATGAGAGAGGCCAAGAGAAATTTACAGGTATCACTAAAGCTTATAATTTCCCTTTTAAA AAGAAATAAAAACAACTGAGACTCTTCAAAGATGTAAAATGATAAATGAATAACTATTAGGCAATTGAC TAGGCTTACCTTAATTATCCTGGCTAGGCTTAGATTAAATAAGTAACTTGTTCTTGTCCGTCATACTCC CAGTTTAACAATTCGTATTCAATACTCAGAAAAACTGTATATCGTGAACTTAAAAGGCCTTATGAATCA TCAGTAAATGGGTTTGTGGTATTAAACTCTTTCAAGAACGTTATTTTGCCATTCTCTCTTTTATCTGAA TCTGTTAACCCTTTTCTTAACTACCTCTTTTCCTCTCCTTTTCTTCTCTCAATTCTTATTAACATTAACA

[0674] GTTACTATTTGAGCATTTGCCATGCTGTGTTCCAAGTTCTGTGCTAAGGACTTTACATACATCTTCTCA GCCAGGATAATTCACATTCTAAGTAAAATTGTTTGTGGTAGTGAATGACAGTTCCTCTATCAAAATACA TGTTTCTGTTTGTCCTGAACACTCAGGAACAAAGGGCAGTAGAACCTACTAGCAGCAAATGAAATCA AGTACCAAGAATGAGATTATGTTTTTTAAAGTGGACTTAGATTTGTAGTCCAAGATAGCACGCTAAAC ACTTGCCTTTATATCTTTGTTCCTTTCCAGAAATTTCATTGAAATGATAGTAAAGATATGTAAAAAGAAT AATAAAACAGGATAGGATTCTGTCAGAGAACTAGAAATTTTTAAGAATTCCTGGAAGATGGAAAATAT ATG AATG GTTACGTAAATAAG CC AAAATAG AAAACCAAAC AAAATACTAG GAG CTAG ATTCTTACATG AAGGG AG CC ATTCTTAG CAAAATCCTG ATG AAG CAG ATAG CATAGTCAG CAG ATTACAAAG AAGTG G ATTTGCCTCTTGGGTAGTCGTCAGAGTAATTAGTCGAAGGTCTTGCTCTGGCAGGAAGACAAAGTCA TGTGTCTTCATAAATCGAGCTGGTGATATAAATATGAATATTTTGAAGGTGTGTGTTAGTTGTGAGTC CTGTGGAGAACCAAAACAAACCTCAACTAAAAACATTGAAATTCTGAATTCAAAAAAAATTTTTTAAAG GTCATGGCCTGATATTTTTAGACATCTGATAATGGGTTGCTGAGTCCTGAGTCCCCAGTATAGCCTTA CATTGCACATGTCCATAGAGATGTGAATGTTGCCTCCTGGAGTTGTACAACAAGGGGATCCTGTTAG TTCCTCTTCTGTATATATGGAACAAATAATTTGTAGCATTTATTCCATGAAAAAGCTCTAAAAGTCGTT TTCTAAACAAAATTTCTGCCTGGAGAGTTCTATGTGACTGCTGTGTGTGTTTAAATGGTGGAACTGAA CATCAGATGTCCCTGAACCTCAGAGAAATCCAGTGGGGTAAAAAGTAAACGTTAATCTACCGAGGAG TAAAATAATACTCTGCTTCCATCTGGAATATACCAGACTTCTTCTCACGTCTGTACCCATTAGTAATCT GTTTGGAAAACAAACTGCTTTCCCCTACTATACTGTCAACACAACAAATTTTTGTGACTAGATGTGTG GGGGTGTTTTTCCCCACCAAGCAATCTCCAGTTCTCTGTAGATAATCAACTGGGTTCTCCACCCAATT GTCTGCAATTGTTGTTAAGTTGCCTTCAATTTAACTCAATTCTGACACTATCTACCCAGGTATAGCATA GACCCCACAGGTTAAGAGCTCAGTCCCACAAGACTGTCCCCCTCTTGAGATGCTAGTCCCAAGTTCC AGGTTGTGACTTACACTTCTGACCAGCTGGCTATAAATCAAGGATTCCCACATCTTCTAATCTTTGAT CATTTGCTAGAATAGCTCACAGAACTTCAAGAAACACTTAACATTTACTGGTTTGCTATAAAGGATGTT ACAAGAGGTAAAAGACGAACAGCCAGATGGAAGAAATGCATAGGGAAAGGTATGTGGGAAGGGATG CAGAGCTTCTGTGCTCTCTTTAGGAGCATCACCTTCCACTACCTCCAAATGTTCAGCACCCTGGAAG CTCTAG G AAC ATTG C ATTTCAG TG ATTTTTATG G AAG CTTC ATC ATATAG GTGTG ATATTTACTAG G TC AATCTCCACGACCTCCCCACTTCTCAGAGGTTGGTGGATGGGGCTGAAAGTTCACATTATGGCTTGG TCTTTCTTTTGACCACCTTCCATTCAGGAACCCACCAAAACTCACCTTGTTGGAACAAAAGATGCTCC TACCACCTAGGAAATTCCAAGGGAATCAGAGCTCTGTGTCAGGAACCAAGGTCAAAGACAAATATGA GAACAAAAGATGCACCTGGCACCCTGATCACTCAGGAAATTACAAGAGTTTTAGGAGCTCTGTGCCT AG AACTG GG GTTG G AGG CCAAAGG GTTG AAG ACC AAAATATATATTATTATAAACCACAATATCAG A GTTTGTCAACATAATAAACCACTTGCCATTTGTTGGACCTATACAACTGTACAGGAGTAAGTCCACAC CAAATCAACCTAATTTTTATTTATAAATATGACTAGAACACCAACAGCAACAGAGAAAACTCAAGAAAA GAAAGCAACTAGAAGATGTAAAAATATTATAGCTCAGGATGTACTTCATTCTTGAAGCCAAATCAGTT TGATATAAAAATTGAGTCATTCAGAGGACCACAGAGTTTGTGCAAATTGAAAGTATGATTGTTGACTT TTGTTAAACAGAAAGGCCAAACATTAGGATAGCTAGAGTTAATAAGTATTTTGGAAAGTAAAGCTAAA GACATACCTTTTAAGATATGAGATAAAGTGGGCAAATATGAGAAAAAAGATAAGAGACATGGAGAGA GCAAAAGTTCCAACTTCTGTTTAATAAAGAAGCAAACAAAAATAGAGGGAAGATGTATTCACAGACAT AATACAGGAAAATTTTCCTGTGTTAAACAAAAACCAGCCTTCAGATAGATAGGGGCAACTGACTGTCA ACAGGAAAACAAAAACAGAGATTGACCTGGATACTTGCTGTATAATTCGAAAGTTGAAAGAGAACCTT TTCAGAAAGATAAACTGGTAATCTGCGGGAGAATGAAAACTGGATCGTTTTCTCATTGGCAAACTGA GGGCTAGAAGGCAGTGGATCAGGGCCATTAAAGATCTGATGGAAGTTAATAGCCAAGCTAATATTAA AAGTAAGACACTTTGGGTATCTAGGGACTGAAAATTATTTCAGTGGAATATAATAGGTATCTAGAAAT AGATCCCAGAATTTCAGAAAATGTAATATGAAAAAAATGGTTCAATCAGTAAGAAGAAGGTGAATTAT TTAATTTTTGGTGCTGGCATATGTAGAAGAAAATAAAATTGGGCCCACATCTTAGACTGCTTACAAAA GTAAATTCTATCAGAATCAAGAGATTAAATACCAAAAAAAAAAAAAAATGTAAATCTTTCAAGAAAAAT CTAGTAGGCTGCATGTAAAATCTAGGAGTTGAGGTCACTATCTTAATCAAAACTTAATTAGCTCAAAA

[0675] GCTGTAGGAGACAGATGGATTAAATACAATTTTGAAATTATGTATGCCCCCCCCCACAAAAAAAAAAC CTTAACAGAGTCAATAGTCTGTATAAATTTGGAAACAGCATTGGTGCCCAGATACCAAGAAGTAAATA GTCTTCTGAATATACAAAGAACACTTCAAAATTGGCAAGAAAAAGACAAAACCCAGCAGAAAAATAGG GAAAAGATATAAATAGGCAGTTCGTATAAGATGAAATCCAAATGAACAGTAAAGCATGTGAACACTGT TCAGATGCAGTCAGTCAGTTGTGAGTGTACAAATTAAAACTATGAGATCATTTCATCTGTCTGGCAAA ATATAAATTATTATTGGCAGGGGTGTAGTGAGAAAACTGCTCCCTTAGTTAAGGATAGAAATGTGAAG TATCACAGCTTATTGGAAAGCACTTTGATAATATCTGTCAAAATTTACAAGAACTGTATCTTCCAAGCC AGTACTCCATCTATTGGGAATTTAGCACATAAAAGCACCAATATTTATACAAGGATATTTGTTAAATCA TCGTAATAAGAAAAAAATATAGAATGTCATCAGTAGAGAAATGGTTGTATAAATCATGGTACAGCCAC ACCATGTAGTACAATGCAGCCTGTGAAAAGACTTGTACTTGAAGGTTTTTCTGAGAGGTATTATAATT GAGAAAAGGAAAGCTGTTGGAAACTCTGATATTACTTACTTATTCTTTATGTATATCACATTGCAATAT TCTAGTAGGTCTAGAAATATCTCTCTCAACTAGAAATGCTGAATAAAATATGTTTATTTAAATGTATAG CTGAGCTCAATAGAAAAACCTATAGAGGGTGAAAACAAAGACGGAGTTGAAAAAACCAGAAAAGCAT AGGAGCTGATATGTTAAGGTATCGCTGAACTATAACCCTCAACAAATCTAACCCACCATCTATTTTTG TATGGCCTGCGAACTAAGAATGGATTTTACATTTTTAAATGCTTGAAAAAAGTTAAAGGAATAATAGTA TTTCATAATCTATGAAAATCACACGAAATACAAATTTTGGCCAGGTACGGTAGCTCATGCCTGTAATC TCAGCATGGGAGGCTGAGGGGAGTGGATCACCTGAGGTCAGGAGTTCTAGACCAGCCTGGCCAAC ATGGTGAAACCCACATCTCTACTATAAATACAAAATTGGCCGGGTGTGGTGCCGCATGCCTGTAACC CAGCTATTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACCTGGGAGGTGGAGGTTGCGGTGAGCC GAGATTGCGCCGTTGCACTCCAGCCGGGGCAACAAGAGCAAAACTCCATCTCAAAAAAAAATAAATA AATAAAATTTCAGTGTCCATCAGTAAAATGTTATTGGAACACAACAATGCTAATCTGTTTATATGTTGT CTGTGGCTGGTTTCATGCTTTAGCAGTGGTGTTGAGCAGTTGTACATCACAGTGTAATCTACAGAAC

[0676] CTCTGGTTCTTTATGGAAGAAGTTTGCTGACCTCTGCGGTCGTGGCCTCAGGTGGGCCAGTTTGTCA CTCTGGAACAAAGGATGTGAATATCAATGTGTGGGAATACAACACTGGGCCTTCAGCCTGTGTCACA AAGGTAGTTGGAACCCAGATTCTCACATAAAGCTGACCCTTTGAAGGACATTACCTTCAGTGAAAGG CTGAAATCTATTACCAGAATACATAAAGATAACAATAAACTTGACTGTCTTTGACAGTACTCTAAATAA AGTTTCCCCTGTGATTTTTTAACTATGGACCTATTCTCATCATTGTGTGGGATTCAAATTTATACTGCC TGCATTGTCCAGGAACCCTCAAGCCATGAAGTGGACATAACGACTGGTCTTGGAGTGGTAATAGCAC TCAGGCACTGCACAGAAGCAATGGAAACCCTCCCTCAGCCCGTCTAGGTCTCATAGAATTCACAGAA ATAATG CTTTACTG ACTATCTCAAG ATCTC AAGTTGTAAG ACATG CAAG G AAACAGTCTACAATCAGT GAGTTAGCAGACTTAAAACAGCAGGGTTAGACTCCTAAGAAAGAACCAAGTAGAACTTTTAGGTAGT CTTGATTTAAACCTCATCATCTATGAAGTATTCTTGCTTGGATTGGGACCTTCTATTTTATAAGAAACA CAGGGGATAGAGGAAAAAGGTAAGCACCATGAGGAAACAATTAGACAATTCAGAATGTTGACTTCCT GTAAGACAATAGCCCTAGACTCCTTGATAAGTTAATGTCTTGGACAATAAAAAGGTTGGGGATTATTC CACACTGTACAAGACCAAGTGCACATAACAACCAAATGCAGTGTGTAATCCTGAGGGGGGAAGAATC ATTCTTGGGACTTGGGAAATTTTTAACATTGATTGAATACTACATATTGTTATGGAATTAACGTTCTTA AATGTGAGGATGGTAACGTAATTATATAGGAGAATGTCCTTGTTCTTAGGAATTACATGTATAAGTATT TAGGAGTAAAGTGTTAGGATGACTGCAACTTCCCCCGCAAACCCACGCTTTTTTGAGATGGAACTTA

[0677] TACACAGTAGAGGGTACAAATCTGAAGTATATCGCTCAGAGTTTTTACATGTGTAACTACCATGTAGA TTAAGATGTAGGACATTTCCTGATGCTTTAGAGGGTTCTCCTGTGCCCCTCCCAATTCACTAAAAATA ACCACTATTTCATTTCTATCTCTGTCAGTTACTTGGAAACTTAACTTCAAATGGTGTGATGGAAATCAA CATGCAGAGAAAGAGAAAAGCAAATACGAAAAGATAATCTTAGAATCTAAGAAAATTTCGATGTTAAT TGTACCATTTGTTCAGATTTTCTGTCTGAAATTTTTTGTAATAGAGTTGGAAAAATTGAAAACATAGAA AAAAAGAAATGTAGAAAGTTCAAAAGAAACAGTTATCTCTAGGAAAAAAGAGTGAACATACTGATACT CATTTGAGGATGTAGCAAGATAACACTTTAAGTAAAATTTCAGTATGTCAAGTTAGTTACAGCAAATTA CATAGGAAATGTTTAAATGTCACATAGAAATTCAAATATTTATTTAAAAAACTCAGTGAATAAGGTAAA GCTAGATTAAACCCAGCCAAAGAATGAATTAGTGAACTCTGGAAAGTGAAGAAAGAGAGTTATAGAA AATATAAAAGAGAGGTTAAGCAGTATGAAAAATGGAATGAGCATTATATGCCTCAAAGAGTTCCAAAA GGTAAGAATAGAAATAAATGAGTAGAGAAAAATTCAAATAAATTAGGGCTAACATTTACAAATGACATA AATCTAACGATTTGGGAAGCACAATCTCTGAGTTGGACAAACAATTTGAATCCAGGATAGACATAATA AAACCAAAGAATATTGTTTTAAAAGCACTCAGGGAAAAAATTATATAGAAAATAATTAAAATTAGACTA GGAAAATTTGTTATGGCAGTTGTAGAAATCAGAAAACAATAGAATAATATACTCAGAGTACTGAGAGG TACCTG TAAATCTCTC AG CTAAG TTAAG CTATAAATTTG ATTAG GTTG ACTTG G G C AAATG C AC C ATA AAGTCCTTTCCAGAGAAGGAGTTCACTTTTCATAGGTTCTACTTGAAGGAATTGTCCAAGAAGGTTTA CTGTATAAAG G AAATTG AACAC AG AAG G AATG AAAAGTAAAAATTAAACCTAAAATTTG CAG AAG AAA ACACTACAGAAAATTTTTGTGACCTGGGGTTTGGCAAAGATTTCTTAAATATGACACCAGAAGCACAG TCTATAATGAACGTATTAGTTTATTGGGTTAATCAAAATGTAAAACTTCTGCTCTTCAAAAGACAGTAT TAAGAGAATAAAAAGAGAAACCACAGATTGATAATCTTTGTAAGCCATGTATCTGATCAAGGACATGT AGAATATATAAAGAACTCTGAAAGCTCAATAGTAAGAAAACAAATGGCTGGGTGCGGAGGCTCATGC CTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGTGGATCATGAGGTCGGGAGTTCAAGACCAGCC TGGCCAAGATGGTGAAACCCCATCTTTACTAAAAATGCAAAAATTAGCTGGGCGTGGTGGCAGGCG CCTGTAACCCCAGCTGCTCGGGAGGCTGAGGCAGAAAATTGCTTGAGCTCGGGAGGCAGAGGTTG CAGTGAGCCGAGATTGCGCCACTGCACTCCAGCCTGGGCAACAGAGTGAGACTCCATCTCAAAAAA AAAAAAAAAGAAAAAACAACCCAATTAAAAACGGACAAAGGATTTGAACAGTTTCATCAAAGATATAT GGATGGTAATAAACGCATGAGAAGACGCTCAACATTAGTCATTAGGAAAATGCAAATTAAATAGGCA CGCGATACCCTTACATGCCTCCTAGAATGGCTGAAATTAGAGTGACCATACCAAGTATTAGTGGGGA TGTGAAAGAACTAGAATTTCCGTACACTGCTGATAGGAGTGTTTAATTGGTACAACCACTTTGGAATA AAATTTGGCAGTTTATTTAATGAAACCTTTTCAAAATCCCAACGGGCTTTTTTTTTTTTTCCTCAGAAAT AGAAAGTCCGTCCTAAAATTCATACCGTATCTCAAGGAATCCCGTATAGCCAAAGCAGTCAAAAAAAG TACAGAGTTGGGGGCATCATGCTTCCTGATCTCAAAACTTACTACAAAGTTAGAGTAATCAAAACTAA GTGGTACTGGCATGCAGACAGATGAGAGTCCTGAACTAAATCTTCACATTTATGGTCAAATGATCTTT GACAAGGGTACCAGGACCACTCCATGAAGTAAAGAGAATCTGTTCAGCAAATGATGCTGGCAACTGA ATATCCACATGCAAAAGAATGAAGTGGTACCCTTCCCTTATACCATGTACAAAGAATAACCCAAAATG GATCAAAGACTTGAACATAACAGTTAAAGCCATAAAACTTTTACTACAAGAAAACATAGGAGAAAAGC ATCATAACTTTGG ATTTGTCAATG ATTTCTTG G CCGTG ATG CCAAAAGCCC AG G G AAC ACAAG AAAAA ATGGAAAAATTGTACTATTATCAGAATTTAAAACTTCTGATCATCAAAGGATATAATCAACAGAGTGAA AAGCCAACCTGGAATGGGAAAAATATTTGCAAATCTTGTATCTGATAAGGGGTTAATATCCAGAATAT AAAGAACTCCTGTAATAGCATACAACCTTGTTAAAAAATGGGCAGAGGACTTGAACAGACATTTCTTT

[0678] AATGAAGATATCCAGATGGCCACGAGCATATGAAAAGATGCCCAACATTGCTAATTATTAGGAACATG CAAATCAAAACCACAAGGAGATACCACCTCACACCCATTAGGATGTCGGCTATCAGACAAAAAAGAA GATAACAAGAGTTGGCAAGGGTGTGGAGAAATTGGACCCCTGTTGCACTGTTGGTGGAAATGTAAAA TGGAGCAACTGCTATGGAAAACAGTATAGAGGTTCCTCAAAAAACTAAAAATAGAATTACCATATAAT CCATCAATTCTCCTTCTGTGTATATACCCAAAATAATTGAAAGCAGGATCTCAAAGAGATATTTGTACA CTCATGTTCATAGCAGCATTATTCACTATAGTAGCCAAAGGCAGAAGCAACCCAGATTTCTGTTGATA GAGGAGTGGATGAACAAAATATGGTATGTATATACATTGGAATATTATTCAGCCTTAGGACATTCTAA CACATACTACAACATGAGTAAATCTCAAGGACATTATGTTAAGTGAAATGAGCCAGTCATAAAACGAC AAATACTGTATGATTCCACTTATTGAAGTACCTAGAGTGTTCAGACTCACAGAGACACAGAGTAGAAT GGTGCTTGCCAGGGGCTGGGGGAAGGGGTGCTGGGGAGTTGTTTAATGGTTATAGAGTTTTAGTTT TGCAGGATGAAAAGAGTTCAGGAGATTGGTTGCACAACATTGTGAATGTACTTAACACTACTGAATTG TACACTTAAAAATGGTTGAAATGTTAAGCTTTATGTTAGATATATTTTACCATAATTTTGTGAAATAATA GTATGGTAGTTATGTAAAACGTTAGGCTGGACACGGTGGCTCACACCTGTAATCTCAGTGCTTTGGG AAGTCAAGGCGAGAGAATCACTTGAGACCAGGAGTTCCATACCAGCCAGGGCAACATAGTGAGACC CCATGTCTACAAAAAAAATTTTTAATTAGCCAGGAGTGGTGGTGTACATCTGTAGTCCTAGCTACCTG AGAGGCTGAAGCAGGAGGATCACTTGTGCCCAGGAGTTAAAAGCTACATTGTGCTATGTGCACCATT GCACTCCAGCCTGGGTGAAAGAGCAAGACCCTGTCCACCCCCACAAAAAGTCAGATGTACACTTAG CATATCACACAGCCCTTCTACTCCTCGGTATTTACCCAAGAGAAAAGGGAGCATATGTTCGTAGAAA GATTTGTATACGAATGTTCTTAGTTGCTTTGTCATAGCCCCAAACTGGAAATAACCCAAATGTCCATA AACAGGTGAATGGTTGGATTGTGGTGTATCTATAAAAGGGAATACTACTCAGTAGAAAGGAATGAAC TGCTAATGCACACAACATAGATGAATCTCAAAGTAATTATGCTGAGTGAAAGAAGTCAGACAAAAAAT GATTACACGTTTTAAAATTCAGTTTACATAAAATTCTAGAAAATGCAAACTCTTCTATAGTGACAACAG ATTTGTATTTGCCTGGGCACAGGACTATGGCAGGATGGAAGATTTACATAGGAGCACAAGGAACCTT TCAGAAAGTGATGGGTATGTTCATTATCTTGAATGTGATGATGGTTGCATGGGTATATACGTAATCTC AAAATGTATCAAATTGTGTACTCTAAATCATTGCAGTTTATTGTATGTCAGTTGTACCTAGATAAATCT GTTTGTTTGTTTTTTAATAGCCTTTAAGAAAGCTGATAGTACTGTGGAAATATTATATGAAATAGACTTT

[0679] GGG AG AAAG AATTATTATTAAAATTTTTTTTTCAACTTTTATTTTAG ATTC AG G AG GTACATG CACAG C TTTGTTATCTGGGTATATTGCATGATGCTGAGGTTTGATGTACAAATGATCCCATCATCCAAGTACTG AGCATAGTAGCCAATAGTTTTTCAACCTTTGCCCTCCCCGCTCTAGTAGCCTCCGGTTTCTGTTATTG CTGTCTTTATGTCCATGAGTACCCAAAGTTTAGCTCCTACTTAGAAATGAGAACATTTGATATTTGGTT TTCTCTTCCTGTGTTAATTTGCTTAGGATAATGGCTTCCAGCTGCATCCAGGTTGCTGCAAAGGACAT GATTTCATTCATTTTTGTGGCTGCATAGTATTCCATGGTGCATATGCCTTTGCTATTGTGAATAGTGCT GTGTTAAATATGTGGTTTTTTCGTAGAATGATTCATTTTCTTTTGGATGTATATATACCGAGCAATGAG ACTGCTGGGTCGAATGGTAGTTCTATTTTAAGTTCTTTGAGAAATTTCCAAACTGCTTTCCACAGTGC CTAACCAATTTACATTCCCACCAACAGTGTACAAGCCTTCCCTTTTCTCTGCAGCTTTGCCAGCATCT GTTGTTTTTTGCCAGCACTTTGGGAGGTTGAGGCGGGAGGATCACTTGAGGTCAGGAGTTCGAGAC CAGCCTGGCCAACATGGTGAAACCTCATCTCTACTAAAAATACAAAAAAAAAAATTAGCCAGCCATGG TGGTGCACACCTGTAATCCCAGTTACTTGGAGCTGAGGCAGGAGAATTGCTTGACCCTGGGAGGCA CAGGTTGCAATGAGCTGAGATCCCACCACTGCACTCCAGCCTGGGTGACAGAGCGAGACTCTGTCT CAAAAAAAAAAAAAAAAAAAAAAATGTAATTCAGACGCTGGGTGTAGTGGCTTGCGCCTGTAATCCCA ACACTTTGGGAGGCCAAGGCAGAAGGATTGCTTGAGCCCAGGAGTTCAAGACCAGCCTGGGCAATG TAACCAGACCCTGTCTCTACAAAAAATTAGCCAGGTGTGCTAGCATGAGTTTGTAGCCCCAGCTACT TGGGAGACTGAGGCGGGATAATCCAGGATTTTGAGGCTTCAGTAAGGTATGATTGTGCTGCTGCACT CCAGCCTGAGCAACTGAGTGAGTCCCTGTCTTAAAAAAAGACTTTCTAGATCCTGGAGTATGTGCAA TAACTAAAAAGAATAAGCATATATGTTCCTTGAGATTTTTATTTTTAATTTTATTTTTTGAGAGTGAGTC TTGCCCAGAATGGAGTGCAGTGGTATAATCACAGCTAACTGCAGCCTTGACTTCTCAGGCTCAGGTG

[0680] ATCCTCCCATCTCACCCTCCAAGTAGCTGAGACCACAGGCGTGTGCCATGCCTAATTTTTAAATTTTT

[0681] TTGTAGAGGTAGGGCCTTGCTATGTTGCCCAGGCTGGTCTCAAACTCTTGGGCTCAAGCAATCCTCC

[0682] CTCTGTGGCCTCCCATAGTGCTGGGATTATAGGCATGAACCACTGCACCTGGCCCTGAGATATATTT

[0683] GAATAATTGTAAAAATCTGTTAATTGGGGTTATTGGAGGGATGGGGATATTCCCTGGGACAAGAAAA

[0684] AGGGACTGACCTTTTACTTTTATACTTGATACCCTTATTTCACATAATGCCAAGGTGTCTGTTTTTTAT

[0685] GATTGTTCAGGGTGATTATATATTTATTCATGTATTGTTTAGAGTAGTTGTATCTCATTTAGCTATTTCT

[0686] TTCTTGATGGATAATTAGGTAATGTTGCAGTATATATTTAAGTACATATATCCTGAAACACTGTGGGAA

[0687] TACTTTTATTGGGGAAGATAAATACCTTGAAATAATTATTGGGTCATAGAATATACACACTGAAAACTT

[0688] TGCGATAACTTAATATCAGAAAAGATTTTGATTCTCAACAAGTGTATGAAACTTCCTTTTCCCACAAGA

[0689] TCCTG G CCAACATG G AATGTTAACAG ATTTTTAAAAGTATTACCAATCTAATAAAATTTAAAGTATATTT

[0690] GACTTGAATCCTGTGTGTATTGTTTGTCTGTATGACAGTTGTTTGTATTATATGACAAAAAATTAACCA

[0691] AAAAATATTAGACTCACCTGATTACCCCAAAAGATGGCTTGTGTTCTAAGCCTGTTTAGGCTTATAAG

[0692] TCAAAAGAAAATTTCTTTAAAAAAATTTTATTTGATGGTTTATTGAGATATAATTCAAAAGCCATACAAT

[0693] TTACCCATTTAAAGTATAAAATGATTTTTGTATATTCACAAAGTTCTGTGGCCGTGATAATTCATTTAAA

[0694] AATATTTTTTCATCCCAAAAATAAACACTGTACCCGTTAGCAGTCACTTCCCATTCCTCCCATCCCTAT

[0695] GTAACCACCCATTTGCTCCCTATCTCTATAGATTTGCCTATTCTCTGGCATTTCATATAAATGAAATCA

[0696] TACAATATGTGTTTGTGACTGACTTCTTTTACTTAGCATAATGTTTTCAAAGTCCATCCACATTGTACC

[0697] CTGTGTCAGTCCTTCATGCCTTCTTATGGCTCAGTAATATTCCATTGGCTGTATATACCACATTTTGTT

[0698] TACACATTTATCAGCTGATGGACATCTGTGTCGTTTCTACTTTTTAGCTGTTATGAGCAATGCTGCTGT

[0699] GAACATTCGTATTCAAGGTTTTGTGTGGACATATGATTTCATTTGTGCCTCTAGTAACCTTTTAAGAGA

[0700] CTGGCAGAATGTTTTTCAAAATGGCTACACCATTTTACTTTCCCTTGAGCATGAGGGTTCTGTTTTTTT

[0701] CACATCACTGCCAAACTTGTTTATTATTTGTCTTTTTTATTATAGCCATCCTAATGGGTATGAAATGGT

[0702] ATCTCATTTTGGGTTTTATTTGCATTTCCCTTATGACTAGTAATGTGAAGCATCTTTTTGTGTGATTGTT

[0703] GGCTTTTATATATCTTTGTGGAGAAAGGATTTGCTTTTATATAGATAGTTTTACATGCAATTCATAGAT

[0704] AAATACCAATGACCTGAGACGAGAAGAATTACAAAGGTTTTTGAACAATGCTCTAATAATAGAAATCG

[0705] GACAGAAAAGAGAAAGTAGCCAAGATTATTTCCTCTAGAGATGGGAAAATGTACAAGTTCTCCAAGG

[0706] ATCTATGACACAACAAGAGAAAGAAGTGGAGATAACAAGAATAAAACTGAATGCTCTAGAGACACAA

[0707] AAGGGAAATACTGAAGATAGGTAAGCTCTCTTCAGTATCTTCTTTGTTTTTAAGTTTATTCCTAGGTAA

[0708] GCTATCTTCAGTGTAAGGTAGACTACGTAAGATAGGTAAGCTGTCTTCAGTATAAGGTAGACTAGATA

[0709] AGCTATCTTCAAAATAAGGTAGACTAAGTCAAAGGATTGTAATATCAAGAAATGTGATAGACCCTGGA

[0710] TGTGGTCTTTTACATCACTAAATGAAAACCATACTTAATAAGTTGTATATAGTATTGTAAAGATAATTG

[0711] CCTGTTTTAGGTATTTCAAAATTGGTGACTTTGGTTTAGCATTTAGAAAATATTGTTCATAAGGTTTTTT

[0712] AACTTTTTATTTAGAAAATTTAAAACACTTGGCCGGTGCTGGCGTGTTGGCTCATGCCTGTAATCCTA

[0713] GCACTTTGGGAGGCCAAGGCGGGCGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAAC

[0714] ATGATGAAATCCTGTTTCTATTAAAAGTATAAAAATTAGCCAGGCATTGTGGCGCACACCTGTAATCC

[0715] CAGCTACTCGGGAGGCTGAGGCGGGAGAATTGCTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCC

[0716] AATATCGTGCCACTGCACTCCAGGCTGGGCAACAGAGCAAGACTCCATCTCAAAAAAAAAAAAAAAA

[0717] TTAAAATACTTGTATGGAAAAATATAAAGGACAATATATTAAACAGCTGTTTAGTCACCTACAATGAAC AAATACTAATTTTTTGTTATATTTGCTTCATATTATACATAGAAGTACAAATTTAGGTTCCACTACCAGT CCCATTCCTCTGCTGGACACCCATCGTCCCATCTTGTCCCCAAAAAGACAGTCACTATGATAAATGT GAGGTACCTTCAATCATATTTTTGTATTTTATTATATATATGTGTAGCCATAAGCCAATGTTTTTGTTTT

[0718] TTTTTTAATTTGTAAGGTGATACGATACTATATGTATGTAATGGTCAGCATCTTGTCCTTTTTATTCAAA ATTATGATTTCAAGGTGTATGTATTTATATGTTAACACATACAGATCTATTTCATTCAATGCTATTATCA AGTATTCTAGCTTCTTAATATACCACAGTTTATCTTTTTCTCCATTGATGAGCATTTAGGTTATATTTGG ATTTTTTTGTTATGACAAACAGTGCTGTAATAAGAACATTCTTGTGCTTGTCTCCTTGTACACATATAA CAAGGTGTCACAAACCTGAAAGTGGAATTCCTGGGACAGGGAGTATCATTTGAAGAGACTGTCCTTT CCCCAGTGTATGTTCTTGGCACCTTTGTCAAAAATGAGTTCACTGTAGATGTATGGAATTATTTCATT

[0719] GTTCTCTATTCTGTTCCATTGGTCTATATGTCTGTTTTTATGCCAGTACCATGCTGTTTTGGTTACTAT AGCTTTGTAGTATAATTTGAAGTGAGGTAATGTGATTCTTCCAGTTTTGTTCTTTTTGCTTTGGCTATT

[0720] CTGGGCCTTTGGTAGTTCCATATAAATTTTAGGATTATTTTTCTATTTCTGTGAAGAATGTCTTTGGTG TTTTCATAGGGATTACATTGAATCTGTAGATTACTTTGGGTAGTATGGACACTTTAGCAATATTGATTC

[0721] TTCCAGTCCATGAACATGGCCGGTCTTTCCATTTTTTCATGTGTTCTCTCCAGTTTCTTGCATCAGTGT TTTATAGTTTTCATTGTAGAAATCTTTCACTTCTTTGTTTTTAAGTTTATTCCTAGGTATTTTATTTGTAG CTATTGTAAATGGAGTTACTTTCTTGATTTTTGTTTCGGATTGTTTGCTGTTGGCATGTAGAAATGCTG CTGACTTTTGTATGTTAATTTTGTATCCTGCAACTTTACTGAATTTGTCAGTTATAATTGTTTTTTTGGT GGAGTCTTTAGGTTTTTCCAAATATAAGATCATATTATCCACAAACAAGGATAATTTGACTTATTCTTT CCAATTTGGATACCCTTTTTTTTTTCTCTTATCCAATTGCTCTAGCTAGGACTTCCAATAGTGTGTCGA

[0722] ATAACAGTGGTGAAAGTGGGCATCCTTGTCTTGTTCCAGGTCTTAGAAGAATACTTTCAGGTTTTTTT CATTAATTATGATTCTAGCTGTGGGTCTGTTGTCTGATGAAAAGTCTGAAACGGTACCTAAAACTACT

[0723] AAATTAATTTTAACATCTTTGAGTTGTTTTTAGTTCTGTGAGAAGAGCATATCTATTTTGGTTTACTCAG TGAGTAGAGTAGTGTCTAATACTGAGTAAATGTACTGTAAGTATTTTTGAAAGAATGAGTCTTTGGGT TTACATACCCTGGGGTTTGTAAACAAATATCTGTTGATTGGCATTAATCCTGATGGTATCCAAGGTAC

[0724] AGGAATGGCAAAGGGAAAAGATAGGGCAATACTGACTGATGCTTCAAAATCATGCCCTAGTTATGCT ATAATCAAGCAGGAAATGTTTATGGAATGGAAAGATTAAGGAAAAGGTATGTTCTTATTTTAGCAATAA

[0725] AACGAATACCAGAAGCTTTAACATTCACCAGTACAAATAAATAGTTTCAATGGAATAGGTCGAAAGTA AAGGGACATCACTAGAGTAAATGCTAGACCTTCCCTCTCCTTTTATTTTTAGCAACAGCAAAGCAGAA

[0726] ACTAAGATCTACAAGTGATCAAAGAGGGTGATCCATTCAGTTTCTGTGTAGACAGGAATAATAATAAT ACCTTTTACATATTGGTACAGTTTGTAAAAACACTTTCACTTACTCATTTAATCTTCATAGCAACTTGAT GAGGTAGAATACTATAGGAAGCAGTATTAGCTCAGGTTGGTACGTAAATTACTGTGTTTAAATTTCAA

[0727] TAAAACAGCTATGGAATCCAAGACATTCTTGGCGCCTAATAAACTGTATTCTTTGCCAACAGTGAAAG TGCTTCTCTGTTGCTTGGTAAGTTTTTTCCCCTTAGAATACTAATAAAGTAATTGATTAACTTTCATTTT

[0728] TATTTTGATTTGATTGGGACAGCAATTTAGCAGTAAAAAATGTCACCTTTATAAATCCTGTGGTTTCTG GTTCTTGG CCAGTTAAATTCAACCTG ACCAGG AG G CACG CTTAATTCTAAAATTG CTTTTACCTTCTG AAGTTTTTGTGGTATAGACATCCTCCTTTTTCTACTTTAATGAAAGCATGTTATAAGCAGATCATAACA ATTTTTTTTTCTTTAAAACAATATTGTAATTAGGCCAGTTGCAGTGGCTCACACCTGTAATCCCAGCAC

[0729] TTTGGGAGGCTGAGGCAGGCGGGTCACTTGAGGTAAGGAGTTCGAGACCAGCCTGAGGAACATACT AAAACCCCGTCTTTACTAACAATACAAAAAAATTAGCCGGGCTTGCTGGCACATGCCTGTAATCCCA GCTGCTCTGGAAGCTGAGGCATGAGAATCCCTTGAACCTGTGAAGTGGAGTTTGCAGTGATTCTAG GTCGCACCATTGCACAAGCCTGGGTGGCAGAGCAAGACCCTGTCTCAAAAAAAAAAAAAAAAAAAAA TGGCTCACACCTGTAATCCTAGCACTTTGGGAGGCTGAGGCGGGCGAATCATGAGGTCAGGAGATC GAGACCATCTTGGCTAACAAGGAGAAACCCCGTCTCTACTAAAAATACAAAAAAAAACAAAATTAGCC AGGCGTGGTGGCAGACACCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATGGCGTGAG CCCGGGAGGTGGAGCTTGCAGTGAGCTGAGATCACGCCACTGCACTGCAGCCTGGGCGACAGAGC GAGACTCTGTCTCAAAAAAAAAAAAAAAATGTAATTGATGTAATAGTCCCAAAAAAGAACTTGGCATTA AGTTAAATTATAAAATCAGAAAGCTATGTAATTTAAATTTGTATTCAAAATCTGTATATTGGCATGTATA TTCTGTGCCAGTTTATTTAAGATGTTACTGTATCATGAAGCTTACTTAAGGCATATAATCGTCTGCACT GTAAAACAAACTACCAAATTAATGTACTATCTCAAAGAATTAAACATATAACAATTTTGATGACCACCT AAATTTTAGAACAACTGTTTTTTTAAAAAACTTTTTACTATGGAAACTTTTATATATATAATATATATAAA TTATATATGTTATATATAATATATATATGTTATATATAATATATATGTTATATATAATATATATGTTATATA TTGTATATAAATTATGTTATATATAAATTATATACATTATATATAAAGTATAAATTATATGAATTTTATATA TATATATTTTTTGAGATGGAGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTGGCACAGTCTTGGCT CACTACAACCTCCGCCTCCTAAGTTCAAGTGATTCTCCTGCCTCAGCCTCCCTAGTAGCCAGGATGA CAGGAGCCTGCCACCATGCCTGGCTAATTTTTGTGTTTTTAATAGAGATGGGGTTTCACCATGTTGG CCAGGCTGGTCTTGAACTCCAGACCTCAGGTGATCTGCCTGCCTTGGCCTCCCAAAATGCTGGGAT TACAGGCATGAGCCACCATGTCTGGCCAACTATGGAAAATTTTAAACATACATAAAAGTAGAGTAGTA TATGAATCATTGTGAGCTCATTAACAAAAGATAATTTCAGTTCACTTTAAAAATTGACGTGTGAAAGTT TGGACTCATACATTTTGTTTTGGTCTAAAGTTTCCTTGGCAAATATTCACATGGTTCCATTGACTCTGG

[0730] CTCCTTTTTAAG ATAG G ATGCTTTTTTATTTTTTTAAG AG AAAAATTATTG CTCTG ACAAG CTAATC AAA GATATTTAATTTTGGAATTTGGAGGAAAGGCATAAACCTAGTTTATTACAAAAATACCTCTTTTTAGTTT TCCTAGCCTTAAAGTAGGAGACAACCTCCCTCCCTTTACACAGGTTATACTTTCATATGGTATTTGCA TAAAGAAATCTTGTTTTCACCCTGGCCTAAATATACATCCAATTTTCTCTGCACCTTTTAGGTAACTCT TTTTTAAGGAGGGTGTGTGTGTGTGTGTGTGTGTGTGTATGTATGCGTCCGCATGCATGTGCATGTG TGTACACGCATGTATGGATTTTCATGGTTTTTAAAATATAGACATAAGTACAAATACATTTATTTCCCC ACTCTTCATACATAAGATACATAATACTGTATATATCATTCTGTATTTTGTTTTTAACGTTTATGTAGGC CATTCTGGAAATTTTGTTTCATACATAATTTTTTATATATATACAACTACAGTTCCATTGTATAGATGTA CTATAGTGTATTTAACCAGTGATGTGTGTATGGTCATTCAGGTTCTTTCTAGACTTTTGATATACAGTC AGTACTGTAGTGAATAATGTTGCACATACATTATTCTTATGTATTGCAGGCATATCTGTGAGATAGATT CCCAGAAGTATGCTTGACTAGGTCAAAGAGAAATTTGCATTTGTGACTTTGATAGATACAAATTTCGC TTCATGGATCTTGCTTAATTATGAGATGTCTGTTTATAGCTTCATACCAGTAGAATATGTTATCAATTTT TTTTTGGATTTTTGCCAATCTGATAAATGAAAAATAACTTCACTAGTTTGGGTTTGCTTTCCTCTGAGT GAGACTGAACATGTTTTCATATGTGTGAAGGCCATTTCTACTTCTGTTTCTGGGACCTGTCTCTCATA TATTTTTCCCTTTTTCTCTTGGGTTATTGGTCTTCATCTCAATTTTTCAGGAGCTCTTTGTGTATCAGG AAGCTAACACATCTGCTAAATGAGTTGCAAATATATTTTTCACCATTTGTACTGTCTTTTTACTTCACTT TTAATGTGTTTGTTTTGCCATCCAAAAGTTTTTTTTTAGCTTTATGTAGGTGAATATAATATTTTTTTCCT TTATGACTTGTAGATTTTGCATCAGAGTTATAAAAGCCTTTTTCATTTGAAGATTTGAAGGTGCCATGC TTTCTTCTAGTTCTTTTATGGTTTGTTTCACTCTCCTTCCCTTTCTTCCTTCCAGCATTTAAATATTTGA TCCATTTGTAGTTTATTCTGGTATACAATATGAAGTATGGATGAACCTTTTTTTCTAGATTAGTTCCAG

[0731] TTGTCCCAGCATCAGTTATTTAAAAGTTCATCTTTACCCCATTTCAGATGTTGCCTTTATCTTATTCGC

[0732] ACTTTCTTTATGTGTTAGGGTCTATTTTGGTCTTTCTGTTTTGTTCCATTGATTTCTTCATCTGTTGTAC

[0733] AGGTACTATCATGAAAGAACAAATAGTATAAAAATTCAGCCTACAAAAGTGGAATTAAGAAGGACTGA

[0734] TAGATGGCTTGCCTTGGTAATAGAGCAGAAAACCAAATTTTTGCCTGTTGATGAAATATATATGCAAC

[0735] TTAGGATCAGCATATGTAGAGAAGCATGAGGGAGCATAGCCATATTTGAAGTGCATTACTGGAGTGC

[0736] CTAAGGGAAATTACCAAAGAGGCTGAAGGATAGATAGCTCCAAGTCATTGGTGGCCTTTTATGACAC

[0737] ATTATGGAATTGGAATTTTATCTTACAAATAATGGGAAAATTTTAAGCAAACTAGTGAAATTTAAGATTA

[0738] TATATTAGAATGGGTTAAATGCTGAGTTCAGTGAACTCAGCGTGGGCTTCAGATTCCACAAACCCTAT

[0739] GAAATTTTGTTTCAGAGAGCACATTTGAGGCTTTCATTAGATTCTCAGAAGTCTTTCTCTCTCTCCCCC

[0740] TCCCACCCTCACACACACACACACACACACACACACACACACAGGTGTGCATGCACATGCATGCCCA

[0741] AAAGTTAAGAATACCTTCTTAAAAGTAAAAAATTAAAAACAAAGATAAAAAAGAAAAAAAGAATGCCTT

[0742] CTTTAGAAAGATTTCTATGGTAACATAGGATAGGATACATTGGATGTGGTTTAAAACTAAAGATCGGT

[0743] CACCAGTCAGGAAATTTTGGCATTAGTATAGGCGGAAGACGAATGGCACAGGGAAAAGTGAGCTTTC

[0744] ACTTAAGTTTATTATTTCTGAAAGGTTACAACCAGTTCTCATTGTTCGTAGTAGTTATGGTCTATAAATT

[0745] CACTACAAACAATTAGTGAACACTGAACCTTGCTCCTAGGGGAAGTACAAGGATTATTATTATTTAAA

[0746] TGAGCCAAAAAACCCCTCTGTATATTGGCCTCTAGGTTGTTTCTTCCATTACAACAGGTTGAGACCTA

[0747] TTGGCTTAAAAGTGTGCTTGCACCAAACTAAATTTTTTGTACATCTAATTGTTTTAAATATAATCCTGAT

[0748] AAGCAGATTTTTAGCCACTGAGAGCCTGCCTACTTTGCAGTCCCCACAAAACTGCTTTGTACTCAACA

[0749] TCTATTAGGTATAAATAAG ATCAAATCCCAAG GCTATAAAG ATTCCAAG CTG CTGTTG CCCTTTG GAG

[0750] CTCTTTGATACATAGACTCCCTGCTGGGTTGTCTAACATTGTCAGCTAGACATATAAGCTCCCTCTCC

[0751] TACTCCCCTCTCCCCTGAGAGTCCCCTAGCCCTCCTCTTCTGGGTGATAGCCACTCCACCTCAGCTT

[0752] CTGGCCAGTCCTGTTTGGGTAGTGGCCACTCTGCCTTAGCCTCTGGACAGTATGCTTTAAGGACATC

[0753] CTCTGCCTGCAGATCTGTCAATGTCACCCAATAAAGCTATGCATGCTACTGCCACCTCGTGGTCATA

[0754] TCTTTTTCCTTGATCAGACCCCAGATCCTTCACATTTAAAATACAGTTAGGTTCCTACCAGCCTCTAGT

[0755] CACATTTTCATCAGTCAGTCGATACGTAACCTTGTTTTGTGTGTGTTTCTGTTTAAAGACATATTGTTG

[0756] ATTCATTAACATTGAACTCACGGCTGACATTACTATAACTCATGCCTGAAGGAAGCTGGCCTAACACA

[0757] TGTACTTACTCTGCCAGGGACATTATAGCCTTCTTATGCTTACCAGCCCTAAACAGCACGTGAGCACT

[0758] ATGCTTAGGGATTATTTTAAACAGAAGAATCATCAACAAGAAGCACAAAAGTGAGAAAAAAGTGGCAC

[0759] CAAATAGGCTCTGCCCAGGATACTTGTTTATAGTATGAAAATTGAAACAAGAAGGCAAGAGAAAGCTT

[0760] CACTGTTCAACCTCAGTTGGAGAGGTGCATGCATTAGGCGACTCAAATATCTCATTGCTCTGCGCAT

[0761] GTCTATGAAAGCACTAAGAGTATTGACTTTAGAGTTACAAATAAATTTTAGCAAGTAGAGAGATTTCAA

[0762] GTATGGACTCCACAAGTAATGAGGATCAACTGTACCATCCAGTCTCTTTAATACTTCCAGTGATGAGC

[0763] CCAGTCTCTCATGACAAACTTTTACCTTGCTGGGTAGGTAAAAGTTCAGGGTTTTTCTTTGTTTGTTTG

[0764] TGACAGTATCTCGCTCTGTCACCCAGGCTGGAATGCAGTGGTACGATTTTGGCTTGCCGCAACCTCT

[0765] GCCTTCTGGGTTCAAGTGATTATCGTGCCTCAGCCACCTGAGTAGCTGGGATTATAGGCGCCCGCC

[0766] GCTCTGCCCGGCTACTTTTTGTGTTTTTTAGTAGAGATGGGGTTTCACCATGTTGGCTAAGCTGGTCT

[0767] CGAACTCCTGACCTCAAATGATCCACCCACCTTGGCCTCCCAAAGTGTTGGGATTACAGGTGTTAGC

[0768] CACTGCACCCAACCTGGATAGTTTTAATGGTTATATTGCACTACCCTCTGCGTCCTGTTATTTCTGGT CATAGATCCTAATTAGGCTTTCTGGACTCTTTCCCCCTTCAATATATTATTTGAATTCAGCTGTCTTAT

[0769] ATTTACCTTTACCCCCTTTTTTTCCCCTCTAGCATAAATATTCCCAATTTCTTTGGAAACTTTTGGTTTG

[0770] CTAAGCACCTCAATTTAAATGAATGGAACTTATTGTTACAAACTAACATTTCCCCTTCTTCTTACACCT

[0771] CCCAATAAAAACTGTGTCCTCTGTATTCACACTGCCTCACTGTAGTCTACACCTTCAGTTCCAAGTAA

[0772] CTCAGATTTGCCTGTGGGGGATGAGGCAAGGAAAAGGCTAAAGATAGATAACTTTAAATATACAGAG

[0773] AGATTACTTTTTTTTTCCCTTTCCCTTTCCCTCCTTCTCTGTCTCTCTCTTCCCATGTCATCTTTGCTGC

[0774] TTCGTATGTTAGCTTCATTCTATAACAGATTTTCTCAGTGTGGTGGAGAATATGGCCATTGAGGGCTC

[0775] CAGATTTGTATCTTCTGCAAATCTACAGAACTACAGTAGAAACAAGGACTTTTCTCTGTCAGTGTCCA

[0776] TGTGTCAATTTAGGGAAGAACTCAGGTACTGTTTGGGTCATATATATAGCCCTGGACCAGTTGCTCTT

[0777] GCCGGGGGTATGGGAAACTGATTAGCCAGCTTCTGTCATCTGTAGTGACATAAAAGTAGTGACCCTT

[0778] GATAGCTTTTCTAGTACCATGTGGATTTCTAGAGAAGGGAATATTCCCAGAGGAAACAGGGGCACCA

[0779] AACAACAAATATCAAGTATACATGTTAAGACAGGTTTTTTTCTTCCCGCTATGTTTAGGGCCAGTAAG

[0780] AGGTCTCTTAAGGACAGTCAGTGTGATTGAAGGGTTATACAGTTTTCAGCTTTGAACAGTATTGGATC

[0781] AAAATTGATTTTGCTTTTAATATTGACATCTATTATTGCTCAGTGATGGATATACTGCGTTGGTGGGTA

[0782] TATTGTAGCAGATACTGTTACTTCTTCTTTTTATATGTTTAAAGTATTTCATAATTTTAATAAAATAGAAA

[0783] ATTAACTTTGCTTTGATTTAAGTTGGTGAATAATAACAAATATTTGGGTTATAATTTCCCTTTAGTATTA

[0784] AGTTAGCTGTAGAAATGGTGTTGTATCTGACCTAGTAACCCATTTGACTTTTTAAAGATGAATTACTAA

[0785] ATTTTTTTAATGATATGAAAAAATGTAATTTGCTCCCTTTACCTCTTATCAATATATTTATGATACCATA

[0786] GGTACCTGCAAGGTGTGGAGTTACAGTCCGAGACAGTCTAAAGAAAGCACTGATGATGAGAGGTCT

[0787] AATCCCAGAGTGCTGTGCTGTTTACAGAATTCAGGATGGGTATGGTTTGTATGTGACGTGAAATTTTG

[0788] TTTAAAAAGAAAATCACACATTAAACTTTGAAGTTTTCTTAGGATCTTTACCAAAACCTAGGGAATTGA

[0789] AAGTGTACTTTAGGAAAAAGTATTAAAATAATACTAAGTTAGCCTGAAGAAATACTGTAGGCCATATG

[0790] AGGAGTTAAATAATTGTATATGACTGTAGGGTTTGTTACTTTGATCAAATGATTTTATTTGGAATTTGA

[0791] GATTCTTACAATTTTTGAACCATTCAGAGTGTGATTTATTTGGATAATAGACTCTTACCCCCCTCCCAT

[0792] TTTTAATACAAACTCATAGTTTCACAAAAGGTATATCAAAATTAACATTTTATATTGACCTACTTTTCTTT

[0793] CAGAAAGTGTCTAACATTGTTCCAAGACCCTCACATTTTGAATCCTCTTTAAAAAAAAAAAAATTATTT

[0794] TGGGGGCATGTTGTCCCTGTCCCTTGAGTACTCTTTTTCCTTGAATGGATAGATAAGTCCGTACCTGT

[0795] GATTTTTTTTTTTTTTTTTTTTTTTTTTGGACCCCAGGAACAATCCATTTTCTGCTGTTGTAGGTCTTTTC

[0796] TGGAGCTGACTTGAAGAAAAGAGTACATCTCTTTACCCTGCTGTTTGTCCAAGAGTGATACATTTATT

[0797] TGGGGTAAACTTAAAATTAATTTATTGCCATTTAAATTTCTAACGATGGAATATTAGGGAGCCAAACCT

[0798] CCCTCACTGTTACTAGCCCCTCGATAACCAATTTTCATATCTTCAGCATGAGGTATATGAATATTTTTA

[0799] GGTGTAATAACCAAGAAAGGCTTGTGTCTACATTTTTCAGAGAGAAGAAACCAATTGGTTGGGACAC

[0800] TGATATTTCCTGGCTTACTGGAGAAGAATTGCATGTGGAAGTGTTGGAGAATGTTCCACTTACAACAC

[0801] ACAACTTTGTATGTATCTTTACATTTTTTTTTGAAATGTCAAAAATGTTTAGATTTTAATGAATGAATTTT

[0802] TATTTAGGGAATGTGAAATATGGATGAGTAATTTTGGAACTGACATTTTACCTGAGTTGAAATCAGTT

[0803] GTTTTCTTTAAAAACTTGTATTTAAACAAGAGTTTAATTTTAATCTTTATACTTTCTTTTTAATTTAAAAA

[0804] AGTAAAATGTATGCATTGTTAAAAGATAATTTTGAATAGTGCAGAAGTATGTCAAGTAAAAAAAGTGAA

[0805] AATACCCTCCTAGAGGCCAACATTTGTTTAGATTAACAGATTATTGTTCTGTCTTCCAAACTTTTTTCT

[0806] GTGTACACAAACGTGTGCTTGTACCTGTAAGCCTAAAGTTTTTTCCTTTCTTTTTTTCTCTCTTTCCTT CATTACTTTCTTTTCTTTTCCCTTTCTTAAATCAAAGTAGAGCCATGCTATGTGATATTCTTTGCCTTAT

[0807] TTTTTTTTAATTCAACAGGATGTCACGGACATCTTTTCATGTCAGTATACCTGGCTTTATTTTAGTATG

[0808] ACTATGTAATAATTCGTAAGAATAGGAATTCATTATATTTAACCATTTCTCTATTGATAGACATTTAAGT

[0809] TTTTGTATTATAAAAAATCTGTTACATACAGGGCTAAACAAGGTCTTTCTGCATATATCTTGACACACT

[0810] TGTACACACCCTTGTGTTTCTGAAGGATAGGTTAATGGAAATAGAATGGCTGGATATTAAACTCTCCA

[0811] TGAGGCTTTTTTCTTTGTCTGGTTTTTGCATTTGCTAGAACCTAGCATAAGCCTAAGGGTCACCAGCA

[0812] TAAGGCCCGGAATGTGGGACCTTTCCACCTTAGAGATGAGGATCTACATAGAACTTGAGAACTTATC

[0813] CCCTAAAATGGCAGGCAGAAGCCAAAAGTTGTCTCTGAATCAGGAATACATTTCTTACTTTTCTCTAT

[0814] GTATGGAATTTTGGCCAGAGTTTTTTCTAGGTGGATAATTACTGCTACCCTTTAGGCGTCAAGTGTTT

[0815] TCCCATGTGTCTTGGTGATTAATCCAGCTGGGCTCTTAAAGCAGATGATTGATTAGATTATTTCCTTT

[0816] GGGGTTTATGCTTTCAAGCCTCCATTAGTAGTGAATAATGAAATCATGTTTGTGTTTCTGTAAGGCAT

[0817] TTTTTGGGAGAAGTGTAAGATACACCTAATGTCAATCAAATTTTACTGTGCAGCAAATAATTTTTTAAC

[0818] ATGTTGAATTTTAAGTGGATAAATCTTAACATTTTTATTTAAGTTCTTAAGAATACAAATACAGTTGAGC

[0819] ATACATTTCATAGTGATTACTACTCTGTTTCTTAATAATTCTTCTTAGCTAGAAATTGAATATGAGGAGA

[0820] TAAAAGAAAGACCTAAGTTGCTAAGTGTGAGAAAATAGTATTAAAATGATGCCTCAGGAAGGTCCTTG

[0821] CCACAGAAGGATTGTGAAAGCAAACTGCAGATTGATTCCAGAGTATGGAAATTGTCACCACTCAGTT

[0822] GGATACCTGCCAGTAAATTTTTATTGAGAACTTTCCATTTGCCAATACCATATCTTACCTAGGGATATG

[0823] ACAAATGAATAAGACAGTGTCACTGCCATAGAGTAGAGAGAAGATTTAATAAATTTTCATAAACATTCA

[0824] TAATTACTATATATGTATAAAGTTCTATAGATGCACAGAGATTCCTAACCTGGCTTTTGAGGAGTTAGG

[0825] AAGGTTTCTCAGAGACAGAAATATCTAAGCTTAGGCCTGATGGATGAGGAAGTAAGTATCAAGTAAA

[0826] GAGTACCCTAAACAGAGGGAAGAGCAAGAAAGCATGTTACCTTTCAAAGTTTTGAAAGAAGTTCAGA

[0827] ATGGATGATACAAGGTTGAAGAGTAGGTTGTTAACAGTATTGTGGGTAGAATAAGAGTTGTGGGTAG

[0828] AATAAGCAGAGTCCAGCTCATGAAAATCCTTGTTAGCCATATTAAAGATTTGGATTTTTCTGTAAAATA

[0829] ATTAGAAATGTAATAGTTGTAAGCTTGGGGAGAAATGTGATTAGATTTGTGTGTTAGAATGATTGCTC

[0830] TGAGTGCCATATAGAGGCAAGATCAAAAACCTATGTTCTGCTTAGAAAGGAAAAGTGTTCTTGGCTGT

[0831] CTTGGGTTTTGCTTGGCTATTCAAGGAGGGCTGCTTATGCCTCATGGTTTCATATTATAAAAGCAATC

[0832] CCTTCAGTATTTCTCTATATCCCAAGAGTCCTTGGGAACTGGGAAGTGGGAAAACAAGATTTGAAACT

[0833] TTTATATCCAAACCTTCTCCTTTTTCTGCAGACACTCAGTGTCTTCCTTCACACAGCCCCACACCTTAC

[0834] AAATTAATGCATGCAAATTACCTTGACTGTGCCTCTCACTAATTTGCCATACATATTTATGTATACTCA

[0835] GATACTAGATTAAGTGTAAGCTGTGACCCAAAAGAAAGATATATCTTCCTGTGCTCATCTTTATTGAC

[0836] AAAGGTATACTTACAGATACAGGCATATATTGCTTAAAATTTATGATCAAATGCATATCCACATGTTTT

[0837] CTTTCCTTCAGCTGTTTTGGTCACCTACCTACTTGGTTTGGTGAATAATGGCCACATAAAAAATTTTAA

[0838] AGATTTTAAAATTTCTTGTATATCCAGAGACAAATGGAAAAAGAACACAATTAGAAATAGACATTTACC

[0839] TGTTTTATATCCCCTAGAAAGTGATACATAGGAAAAAAGGTGAAGAAAATAAGAGTCACTTTTAAAACT

[0840] AAATGTCCTCAAAAAGCCAGAATGTATTATATATCAGGATGTAATTTTCTTGAAATATTTTCAATAACTT

[0841] TCTATTCTTAATGGAACAGAATGTGTAAATAAATGTGTATTGAAAATGGACTTTTGGCTGGGCACAGT

[0842] GGCTCATGCCTCTAATCCCTTGAGAGGCCGAGGCAGGCAGATCACTTGAGCCCAAGAGTTCAAGAC

[0843] CAGCCTGGGTAACATGACAAAACCTCATCTCTCCAAAAAAATACAAAAAGTAGGTGGGCATGGTGGT

[0844] GTGCACCAATAGCCTTGGCTATTCAGCCTGAGGTGGGAGGATAACTTGAGCCTGGGAGGCAGACTT TGCAGTGAGTCATGATTGTGCCACCATACTCCAGCCTGGGCAACAGAGCAAGACCCTATCAAAAAAA

[0845] AAAGAAAAGAAAAAGAAAAGTAGACTTTTGATGTTGAAATCTATTTAATGTATCATAAAAAAATTTACAT

[0846] GTAGCAGAATAGATTAGGAAGTTCTAATTCATGTTGTATATAGTCAGGGTAAGTAGTGTTGTATGAAT

[0847] ACAGTTATATATGGAGTCATAATGTAAAATATCATTATTTGTGATTAAAACTCTGAAAAACTGGGCACA

[0848] GTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTAAGGTGGGCAGCTCACGAGGTCAGGAGTT

[0849] CAAGACCAGCCTGGCCAGCCTGGTAAAATCCTGTCTCATTTGAAAATCTTGTGAGTTGTAACTGGTTT

[0850] TATACAAAATATTGAAGAGTGGAAATTGTATAATTACAATCATGTAATTAAAAGTATTAACCACCCCCC

[0851] CCAAAAAAAAAACCTGTCTCTACTAAAAATACAAAAATTAGCCAGGTGTGATGGTGTGCGCCTATAGT

[0852] CCTAGCTGCTCGGGAGGCTGAGGCAGGAAAATCGCTTGAATCCAGGAGGTGGAGGTTGTAGTGAG

[0853] CCGAGATCGTGCCACTGCACTCCGGCCTGGGTGACAGTGAGACTCTGTCTCAAAAAAAAAATCTCTG

[0854] AAAAACTGAAATGAATTAAGAATATAGAGGCCGAGTGTGGTGGCTCATGTCTGTAACACTCTGGGAA

[0855] GACGAGGCAGGCGGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACTCC

[0856] ATCTCCACCAAAAAATACAAACGTTAGCTAGGCATGGTGGTGCATGCCTGTAGTCCCCAGCTACTTG

[0857] GGAGGCTGAGGCAGGAGAATCACTTGAAACCAGGAGGCAGAGGTTGCAGTGGGCCGAGATCCTGC

[0858] CACTGTACTCCAACCTGGGCGACAGAGCGAGACTCCATCTCAAGAATACAGAGCAAAGAACAAATAA

[0859] TGAAATAGAAGTCACCCATGCTCTCGCCACTCTGAAGTAGCCACTCACATTTTGATATTTATTCTTATA

[0860] TTTTCTTATTATTATATACACTAAATAAATATATTTTAAGCAATTTCTGGCTTTAGTGGGATAGATTCTT

[0861] CCTAGTGCAGTTCTGTTACGTGACTCATGTTCTACATCATTTGCCTTTGACATGGAATTCTTAACATGT

[0862] TGCCTTCTAAGTTTCACCTAGAGAAGTGTTCACAAATAAGTTTATGTGGCCCAAACATTCTAATCCTCT

[0863] AAGAAATTGATCATTTGTTAGAAAAAATAGATCTTATTGTCTTTTAGGTGATTTTTCTGTTTCTTATTTTT

[0864] TTTAGTAAGATTAGGAAGAGCTGTTTCAATTTTCATATGATTACTTACTAGTTTTATAAATAATTGTTTT

[0865] TACATTTTTATCCAAAGTTAACCATTATGTTTTTGGACCATAGATCAGGGGTTCTGATTCTGTCAGCTA

[0866] TTTTGTTTTTGTTTTTGTTTTAGCTATTATGTAGATTGTATTTATAGTCTCTCTCCCTCCCACCCCCAAT

[0867] TCCACTCTGGAGGAATTCACTGTTAATTTTTAATGGTTTCTGTTTTAAGCTCTTTTGGTGATTATTTTCA

[0868] TCTTACTAAATACAGTTACACATTGCCTGATGACTGGGATATGTTCTGAGAAATGCATCAATGGTGAT

[0869] TTTGTTATGTGCTTACACAAGCCTACATGGTATAGCCTAACTATACAACTAGGCTATATGGTAGAGCC

[0870] TATTGCTTCTAAGCTAATAACCTGCACGGAATGTTACTGAACTGAATGCTGTAGGTAACCTTAACACA

[0871] GTGGCAAGTTTGTGTATCTAAACGTAGAAAAGGTACAGTAAAAATACAGTATAAAAGATCAAAAATGG

[0872] TCTACCTGTGTAGGATACCTAATATGAACAGAGCTTTTAGGACTGGAAATTGCTCTGGTGAGTGAGT

[0873] GGTGAGTGAATGTGAAGGCGTAGGACATTACTATTTGTTACTGTAGACTTTTATGATAAACATTGTAC

[0874] ACTTAGGCTACAGTACAGTTTTAAAATTTTTCTTTTTAAAAAGTTTATAAAGTAAAAAATTTACATTAAA

[0875] CTAAGGTTTAATTTTTTTTAACTTTTTGACTCTTGAAATAACAGTTTCAAAAGTTTAAAAACATTATATA

[0876] GCTATACAAAAATATTTTATGTGCTTATTCTATAAACTTCTATTTTAAAAATTTTTAATTTTTCTTTTTTAC

[0877] TTTTTAAACTTTTCTGTTAAAAATGAAGACACAAGCTGCACACGGTGGCTCATGTTTGTAATCCCAGC

[0878] ACTTGAGGAGGCCTAGGCAGACGCATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGTCAACATG

[0879] GTGAAACCCTTCCTCTAATAAAAAATAGGAAAATTAGCCAGGCCTAGTGGCATGTGCCTGTGGTCCC

[0880] AGCTGCTCGGGAGGCTGAAGCAGGAGAATCACTTGAACCAGGAGGTGGAGGTTGCAGTGAGCCGA

[0881] GATCGTGCCACAGCACTCCAGCCTGGGCGACAGAGCCAGACTCTGTCTCAAAAAAAAAAAAAAAAAA

[0882] AAAAAGACACAAACATACACATTAGCCTAGGTCTACACAAGGTCAGGATCTTCAAGGTATCACTAGG CAATAGGAATTATTCAACTCCTTTATAATCTTATGGGACCACTGTGGTATGAAGTCCATGATTAACTGA

[0883] AGTGTCATTATGTGACACATGACTGCAATTATCTTTTAGCCACAATTTCTTGCTTTATTAACTTTAGATA

[0884] TCATATACTGATTACTGATTGTATAAGGAATTAGCTCATTTATAGTTCTTCCTCTCCCTCCTCTCCCCC

[0885] AATATTTTTATTAGTAGTTTTTTGGTTCTTCTATTGGGTGCCTTTGTAACTTTAATATATGCCTTTCTTG

[0886] TTCCGTCAACACCAGTCGGCATTTCTTAACCTCCCTTCTTTGTATGATAATTAAAGTATAGGCTTCTTC

[0887] CTTTCACCTCTGTTTCCTCCTCCTTTTCATGTCTACTTTTACTTTTATGTTGTCAAGCTTGAAATCAGTT

[0888] GCCAGCCTTTTACTCATTTCTCATTTTTTAACTTCTGGGTTTTTAAGTTAGATAGTGGGGTGGGAAATA

[0889] AATATGTGTAGTCCATCTATTATCTTGAACCCCCGGTTTTCATTTTATAATAGTACTTTAGTATGTGAG

[0890] TTTCATGATATAAATATATTACAACTTTGTTATTTTAAACAAGAGAGTAGATACGTCAGTTTCTAGAAAG

[0891] TTTTCTTGTGAGTTTTTGAAATCTCTGTGATTTTTTACTTTGCAGGTACGAAAAACGTTTTTCACCTTAG

[0892] CATTTTGTGACTTTTGTCGAAAGCTGCTTTTCCAGGGTTTCCGCTGTCAAACATGTGGTTATAAATTTC

[0893] ACCAGCGTTGTAGTACAGAAGTTCCACTGATGTGTGTTAATTATGACCAACTTGAGTAAGTAATCCAA

[0894] AAATATCTCTTTTCTACCTACCATTTTACACTTAAATTTTCTTAATGTGAAGCTACGATGTCTAAAAGTC

[0895] TGTGAGGGTTTTTCTTCCATACGATTGTTATAGAGAATTTTTTTTAAGTGTAGTTAGAGAATAATATGT

[0896] GGAATGGACAGTATTTCTCTCCCAAATTGTAATGCTGGTTCAGCTATACAGTTAATTTATATTTTATAT

[0897] TATCGTTTAATTAATCAAGACCCCTAACCCATAGAAACCATTTTTGGATAGTTTCTAGGAGGAGAGGG

[0898] AGAGTTGTTTCAATTAAATTAAGCATTATGATTTTGTACCACAGATCAGGTAGTCTGATTCTGTTAGCT

[0899] ATTTTGTAAATTACGTTTATATTCTTCCTCTCTCTCCTTCATCCCCATTCAGCTCCCTTCCCCCAATTTA

[0900] TTTGAGTAAGATGTAAAATTTTTGTATCCAGTATATATCTCTTTCTAAAATTTCTCTTTGCTGTATGCCA

[0901] GTTTTTCTAATAGATTAGACTGAGTCTATTATCTCTTTTTGTGTCATTGGTGCTGCTGCTGTTAAAGTC

[0902] TTACTTTTCTTGATCACCTGAGCAAATAAAACTTAACTCTGTACTTTAAGTAAATTATAATGTCACCTAA

[0903] TTTACAGTAGATACTTTTTATTCTCATTCTTTAACCATAAAGCATGATTTTCATCTTGTAGTATGTAGAA

[0904] ATTTGCTGAACTGAATGATTAGTTTTAAGTTATAAGCATGCCTTTGAAAGTGCAATACAATTTTTTTTAA

[0905] AATAAGCCTTTAGACAAAAATACAACTAATTGAATTTTAACAGTTGTTTCTGAGAATGGAATTTGATCT

[0906] CAGTTTTTTTGGTTAACTATGTATTTTGGTATATGAAGCTTCTGGGTTTTGCACAAGTTAGGTTTGTTT

[0907] TGTTTTGCCTCACAGTTTGCTGTTTGTCTCCAAGTTCTTTGAACACCACCCAATACCACAGGAAGAGG

[0908] CGTCCTTAGCAGAGACTGCCCTAACATCTGGATCATCCCCTTCCGCACCCGCCTCGGACTCTATTGG

[0909] GTATGGTTTGACTTCTGCTCTTGGGCGACATGCTACTTGAACCGCTTTCTTTTGGATCTCCTGGTTAA

[0910] TTAGAAACCTTTCCAATGTTTAAATTGTTAAATTAAGGACTTTTTCCCCAAATAACTTATCATACCACTC

[0911] AGATATTTACATGCATTTGATACAAATAAATGGGATTAAAGCTGACATAGACTATTTCAGAATCAGTCC

[0912] TGAAAAAATCAATATTGGGTATGATTTGACTTCTGCTCTTCAGTGACATGCTTCTTGAACTGCTTTCTT

[0913] TTGGATCTCCTGGTTAATTAGAAACATTTCCAACATTTAAATGCTTAAATTAAGGATCTTTTCCCCAAA

[0914] TAACTTATTTTATCACACCAGTCAGATATTTACTTGCATTTGGTACAAATAAGTGGGATTAAAGCTGAC

[0915] ATAGACTATTTCAGAACCAGTCCTGAAAAAATCATGCAACAGATCATTTTGAGTCTACACCTTGAGTT

[0916] CATCTTTTATTAGGTATAGAAGTATATGACTTCCACTTATGAAGAAGCATTGATATGTGAGACAATGG

[0917] CAAACAATGTAAAAATAGTATATAATTATAATCTACAATTTATGATGGAGTATATTGAAGTATGTGATG

[0918] AGGACATAAATGTATTCATGTTTACAGAAGGAAGAATAGTGAGGAAAAAGAGAGTGCTCAGGAAAAC

[0919] TTAATGAAGAAGGTGGTATTTGAACTAGACTTTAAAGAATTACTACAATCTGAACGGGCCTAGGGAAT

[0920] AGAAGCATGGTGAAAGGGGAATGGAGAAACAACAGATATAAAGGGAATAAACAGATATAAAGGGAAT GAAGATGTTAGGTTTAGAAGCTAGTGAAGAAAGGTTTATCTAACTTAAGAACTACCATGTGTAAAACC AGATTATGGAGAGTCTTGGAATTGAGGCCAGAATTTAGACTTAAAGGTCTTTAAGCAGATTACTAACT TGATGAAAATGGCTTTAAAGAAAAAATCAATTAGCAGTGAAATACAGATGGATTGACAGAAAATTTAG GGTGAAGAAGGCCAACCTAGGATGTTGTTGGTAGTGAAAACTGAGAGAGGCAGTGAAGACAAGTTC AAGTGCTAGAAGTATGGAAAAGGGATAGATATTCATAAAGCGTAAAAGAAAAAAATGAACAGTATTAT TAATCAGTTGAGGATAAAGCTGAGAAGTGACTTTAAAAATAATGCAAAGGCAGCCGGGTGCGGTGGT TCACGCATGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGCAGATCACGAGGTCAGGAGTTCGAGA CCAGCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAGATACAAAAAAAAAAAAATTAGCTGGGC ATGATGGCACACACCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCTGG G AG GTGG AG GTTG CAGTG AGCTG AG ATCG CACCATTG CACTCCAG CCTGG GTG ACAG GTG AG ATTC TGTCTCAAAAAAATAAAAATAATGCAAAGGCGTCATTTAAGCTTCATAGTAGGAAATAAAAAGGAAGA CACAATAAAGATGAGTTAAGTGGGTATCAGTTTACTTTGGAACATTTCTCGAACTCCTGGCCTCAGGT GATCTTCCTGCCTCAGCCTCCCAAACTGCTAGAATTACAGGCGTGAGACACTGCACCTAATTAGCTT TGGAACATTTCTGACACAGGTCTGTGTACTCTTTCACATTGAATTTGGGGCAGCGTTATTTAGGCTGC GTCTGGAAGCACATGCTTTAAAAAAAAAAAAAAAAAAAAAGGCCGGGCGCGGTGGCTCACTCCTGTA ATCCCAGCACTTTGGGAGGCCGAGGCAGGCGGATCACGAGGTCGGGAGATCATGACCATCCTGGC TAACACAGTGAAACCCCGTCTCTACTAAAAATACAAAAACAAAATTAGCCGGGCGTGGTGGCGGGTG CCTGTAGTCCCAGCTACTCAGGAGTCAGGAGGATGGCGTGAACCCAGGAGGTGGAGCTTGTAGCG GGCCGAGATCACGTCACTGCATTCCAGCCTGGGTGACAGAGCAAGACTCCGTCTCAAAAAAAAGAA AAAAAAAGTCCCCATACAGCATTCTGTCCTAGAATATTCCTGAGATGTTAAGATTAGAAATATTTATTG TCAGTTTTAACCCTACTTCCTCCCACTCTTCACAGTGTAATGCCATTTCTTCAGATTTCTACCTAGAGA AATCTTTTCAAAATCAGTTGACATTTTCAGTACAACTTTGTAATTTTTACAAAGCCAACCTTTCTGGTG ATCTCATGG GTTAGAAAATTTTG CAAAAGAATTTTGTCTTAAG CAGTG AGTATACTTACCTATTTG GAA CACTGGAAAATGCAGCCGTTGTGTTCTCTTGTCAGGTTGTAGCAGTTATCTCTTCTAGTGGAGTCATT TTATTCCCGTTGGCTCTATCACTACTTGTGTGCAGCTGTGTTTTTTTTAGATGGTCAAATCAAAATGTT ATTATTTGGTTGGTTTTTAATTAATCTTTTGGTTATAATATTTTCTCCTGACAGATTCTGTAGACCATGA TGCCTTTCTAATGGCAGGTCCCAGTTCTGTGAGCAGTTATAAAACACCCTAATGAAATTAGCTTGGCC TCTCTGAAGGTTTATAATGGTAATGATCCAGGACATTTGCCTTCCAGTGAAGGAATGCTATCTTAAAA TTAAGAAACCATTTGCCTGTGCCATGAATATTTTATTGGTAACTGAACTGAAATATATTCTGATCTTGA GCAAATGATAAGATGTTCAAACTTGTCTGTAAGTCATTTTCCTGATGTTTTTATGACATAACTCCATAT GGTTGTCTCTGTAAAGATAGAAGCCAATCTTGTTCAGTATCAAAACTCTTTTGCAGTTTGTTACTAGTC CTGATAACAATAATAATGGTCATGAAACAAGTGTAATAATGGATGTAATCAAGAAATATTGGAGAAGC

[0921] AATACATTGCCCAGTTTTGAATACAAAGTGAGAGATACCTCCTTTTCTACTTTTTAAAAATGCTGTAGA ATGTATAAATTTGTGAGAGGTCAACATTTAAAATGTACGTATCACCAGACCAAAGTTTTCAAAACTTTT AAATATTCTAGATTAAGAATGAGATCTAAACTAACTGGTAATTTGCTGAAGGGTATTATAATTAAAATT CCTTTTGTCTTTAATTTGGTACTGCTTTAAAGAGGTTTACTGCAAGATAGGTACAGGTATCATTGGGA GAAAGCCAGTTTGCCGACTGCCAAGATACTTCATAGGGTATAAGTTACCTTGGTTAGTGGAAAAATTT CCCAGTATGGTAATGTAATTTTATCGATTCCCAGAAATGATGAGATTGGGAGTTATACTGGTTTGTAT TAACTGAAATCAGAAAAAAAATTGAATCAGGATACCAGGTAATATTTTTCAGTGAAAAATATACCTGTT ATGTAAATTAGACTTCTTGTGTTGTGTGCGCCACCACTCACTCTTCTTTTGTAAGAGATTTATGGGAA ATCAAATTATAATCAGAAGACTGTTTTCGTTAAGCATAGAATTAGGACATGGCTGAGATATTCAATGA CATCAGATTATGATCACTTCAAGTGTTCCCTTGTACTTGCCCTGAAAGCTAGAGAAGTTGACTTGGTG GACCAAGACACAACTATTAGATACCAACTACCAAATTGAGTTTCTCTGATTTTGTATAATACGCAGATA TCATCATTTTCTAATATATACATTCTTTAGATATGATAGTGAAGTGTCTTAGATTAAATCTGGTTTTTGT TTTTCTTCTGGACCAATGTCTTTTGCATACTTAACTCTGATTTGTTATCTACTACATGTTTCTGTCATAT TCCTAACTTGGTGAGTTTCAGAAGTGACTTACTGCCATCTCTGCCTATCCCAGATCAATTATTACAGT AGACTATCTTATGCAATTCTAGTTATTCATACTTTTTCCAATTTTAAGCCTTTTTTTTTTTTTTTTAAGAT GGAGTCTCACTTTGTCACCCAGGCGAGTGCAGAGACGTGATCTTGGCTCACTGCAGTCTCTGCCTC CCTGGTTCAAGTGATTCTCCTGCCTCAGCCCCCTGAGTAGCTGGGATTACAGGCCCTTAACACCACA CCCAGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTTACTATGTTGGCCAGGCTGGTCTTGAACTC CTGACCTCAGGTGATCCACCTGCTTTGGCCTCCAAAAGTGCTGGGATTACAGGCATGAGCCACTGC

[0922] ACCTGGCCTGCCTTGAGACTTTAAATCAGCCTGTAAATGGTTGTCAGTCAGTCAGTGCCCTTTCTAAA ACTTTATTGACTAATGTCATTTTTGCATTCTTTTTCCTGCTCCTAAAATTTTCTAGCTATAGACATATAT TTGGCTACCTAAAGCAAAAATAAAGACAGCTCTGTCAGAAACCAAAAGTTTCTCAATAATCAGAAAAA ATAAAAAGGACCTAGATGGAACATGCTAATTTTCCTAAAGGCTTGTTTCTTACCTATAATTCTCATTGA GCCGATACCAATTTTTTTTTAGTACATAATATTTTATTATTTGCATATCAATTCTAAGTGGATTCATTTC ATTAATATAAACACATGAAGTCAAAACTTCTTTCCTTATCTTTAATAATATGCTTCAAAGAAGTAAAATT GTGAACTGGTGTGGTTCAGATTCTGACATGTTTTATTCAGAGACTGACTTTCACTGTTAGGCTTCCTT GGCTCTTCAAACCTTTATTCATTCCTTTCCTACTATATTTTTTTCCCATTCCTCACGTCTCACAAAAGT GTCTTTTTATTCCCTCAACATTGTCTTTCTAGCTGTGTCTTAGTAACCACTAATAATTAGTTTGCATAAA ATAGGGTGGAATGATAACCAATATGTGAAGAGAGCTTATTGGCACTTAGCCATTCATTGGTCCTGAT GGAGTTAAGTGAGACAGCTTACCTCATCTATCAAGTGACACTCATTTCCCCACTCCTAGGATACCCTT TCTGAGGGGCTACATCCTTCCAAGTGTTTACAATCTAGTCTCAAAACTTTAGTGTTCTCTGTGAGTGC

[0923] CAGGTTCATTTTAGGGTGAGATATCATAGACTATGTTATTTAGCTACCATACCGAAATAGGTATGTAA CATATTTTGGTGATTTTCCAAATAGCATACAAATGTAACATTTTGGTGGTTTTCCAAATAGCAGTTTTC AAAAATATTTGCTTTAGTGGTTAATATATGATTCTCTTGTGTCTCTGTTATCAATAATGGGCATGATAA

[0924] AAAATCCAGAATATGAGAGATATTGGCACTCTGAGGATCATCTTCTGAATTTGAAAAGGATTTTTCAAT ATTGTTCTG G ATTTTCATTCAACTCCTGTAAAG G AACAAGTACATC ATTCAG GTCCTG AAATATG CATT TGTATTCTCAAAATATTTATAATTTCTTAATATGTAAAATTTTCATTTTAGTAAATTCAGATGTCAAGACA ATGTTAGAAAAAAATGGCAAATTATATTCAGTCATTCTCAGAGCATTTTTATATAACTTCAAAGGTTGA ACTTCTTCAGTTGATGGCCACAGGTAATTTCTAGCCATAAGTAAATTTCCCTAGTGTTTTCCAGGTAA GAATCAGTGGTCTTATCATTGATAGTTCCTGGAGGGCCTACTTGAGCAAAGCAGCTTTGGCAGTATT GGATTTTTAAATTAATACTTTTAAAAGTCATTACTGCTAGGTTTTTAATGCTTTAATGATTTTGAGAATA TAAAAACAAGAAAATCCTTTTATCTTCCTTTTTAAATATTATTACCTTTATATCGTTACTCTGAATCTTAT CTTCCAATGACTTCATTTTTCCAGGCCCCAAATTCTCACCAGTCCGTCTCCTTCAAAATCCATTCCAAT TCCACAGCCCTTCCGACCAGCAGATGAAGATCATCGAAATCAATTTGGGCAACGAGACCGATCCTCA TCAGCTCCCAATGTGCATATAAACACAATAGAACCTGTCAATATTGATGTAAGTATCCAGCATTGCTA GAACTAAAAAAAAACCAAGTATGTATCTTTATTTTTCTGCTATAATTATAACTTAGATCAGAAATAAGTG CCATTTTTCATTTATCACAGTTATTTTAAGTGATAAGCTTCTTGTGAATCACAAATCAGAAAAGCTTCT

[0925] GGTTTCTCTCTGATGACATTAAATATTTCACTGACTCCAGGTTATACAGTCACTCTGATTTTTTTCCCT

[0926] TATG ATACCATCTCTATAAAAGTCATCTTC AAATG AAAATG GTTTAAATATC AAAG G ACTG ATAG AAG C CCTTGACAGAATTAAGTTCTTTAAAACTTTTATAAAAATGATTATGATTGTGCTATAAGAGGTGGATAT GAAATTAAGAATTTCAGGCCAGGCATAGTGGCTCATGCCTGTAATCCCAACACTTTGGGAGGCCAAG

[0927] ATGGGTGGAACGCTTGACCCAGAAGTTAGAGACCAGCCTAGGCAACATAGTGAGACCCCATCTCTA

[0928] CCAAAAGTAAAACAAATTAGCCATGCATGGTGAGGCATGCCTGTAGTCCCAGCTACTCTGGAGGGTG

[0929] AGGTGGGAGGATTGCTTGAGCCCAGGAGGTCAAGGCTGCAGTGAGCTATGTTTGCACCACTGCACT

[0930] CCAGCCTGAGCAACAGAGTGAGACCCTGTCTCAAAAGAAAAGAATTTCAATTTGTGCTATCATAAGCT

[0931] TGGCATTATGACCAACAAAAACTTGATTTTTTCTGTGTTTATTTTAAAATTAGCATATAATTGAAACTAT

[0932] AAATTTTATTAAATATTAATATAAAAGAAAAACTTATAAATTTTAATTTTGTAATTTTAGGTAAATTTGCA

[0933] AATCAGACTTTCTTCCCACTTTTTACTAAGAAATTTTCTCTATTTTTATTGGGTTCATTTTAAGTGACTT

[0934] TTTTCTAGTACTAGTTTTCCTTAACTAGCAAGGTTCACCTCTATCTAGCAAGACCTAAAAACAAAGGAA

[0935] GAAAGGGGAAAAGGAGAATGTGATATAAGAAATCAAACCATATGTCCAGGTTAGGGTTGTTCTCAGT

[0936] CTGTCCAAAATTGCAACCTTCATCTTTACTTTGAAAACTATCATCCTTTTAGACTATTCCCTTTTTCTCT

[0937] GATTGTTACCACTGTTCCCTGGTATGTTGGGCTTCATTTAGAGTGTCATCTTTGTATCTTGCCTTTTCA

[0938] TCCTCTCTCGTAACCAGTCACAGGGTATCACCTTTTCATGTGCATCTCAAACTGGTTTTTACTTATTAC

[0939] CGCTGCCATTTGGGCCCATATTTTTTCACTTGAATTATATACTACATTAATCTCCTAAATAGATTTTCT

[0940] GCCATTGATTTCTCTCTATCTATTTCCATTCCTTCTGCAACTGTCAGAATTTTTTTACACTTCTAGCATC

[0941] ATCTGTTCTCTTGTTCCAAAACTTTTAGTGACTTACTGTTGATTACAAGGTAAAGTGCAAACTCTTTAG

[0942] CATTTTTATTCATGTTCAAGCACTTATGATTCCATTAAAAAGATTTACTAATAACTGTGGGCTATGCATT

[0943] GTGTTAGGCAATTGGGAATTATTTATGAATTAGCACATGGCCTTTGCCCTCAAGGAAGTCACAGTCTA

[0944] ATAGGTGAATCAAACATTTAAATAGATAATTACAAAATATATAATGGTAGTTTAGAGAAGGGGGTAATA

[0945] AACTCCATCTGGTTGGATCTAGGAACATTGAGCAGAGAAGGGACAACCTTTAAGCCAGATTATGGTG

[0946] AATAAGTAGGAGTACACTACATAAGGGGGTTAGGAAAGTCATTTGTTAAGGAAATGAAAGGCATAGA

[0947] AGTGCCTTTACATGGAATGTAATTAATAGTTGATATTGAAGTTTAGGGTCCAGGAGAAGGCTTGGGG

[0948] AATGGTGGAAGGTGAAACTAGGCAGGTAATATCTACAGTGAAAGGCTTTGTGTATTACTCTGAAATCT

[0949] AAAGCAGTGCTAGGGAATCTGAAGAATTTTGATTGGGAGAGGAAGTCATCAGCTCTATATTTTAGAAA

[0950] AATCTTTGATGGTAGAGTGGAGGATAGATGAAATGGGAAACACATAGAGGCAGGACTGTCAATAATG

[0951] TGGTTTTTACAGTATTTCAGACAAGAAATGATATTTAAACTCAAGTAATAGCATTGGTGCTGAGAAAGA

[0952] GTGTGTTTTGGGGAGGGAGACTATGAATTAGTGAATTAGTGGTAAGAGTCTTAGGAATCATGTTGAA

[0953] AATGACTACTATTTATGAATACTTATTACATACAGGTACTATGCTAAGTGCTTTACGTAGACTTTCTTAT

[0954] TTCATCCTCATAAAAACTCATAGGTTATGTACTATGATTATCTTTATTTTACTGTTAAGAAAATTAGATT

[0955] TACAGAGGTTAAGAAACATACCCAGATTACACTGCTGATAAATTACTGAAGTGGGTTCAAACCTGGC

[0956] CTTTCTCTCTTACACTTAACCACTATACTGTTTTGTAGTAGAGGAGAGGAGTGAAAAATATGAGAAGT

[0957] AGAGGATAATGCCAGGTTTCTGGCTTATAGATACTTAGCTTATAGACCGAGTTTCTGGTAAATAGCAC

[0958] AGTTTGTTAAATACCAAAGGAAAACAAGGTTTGCAGAAGCAGCAATTTTAGCTTTTTGGGGGCATATA TTGACTTTAAGATGCCTGTGGGACTTTCAGGTTTAGAAATCCAGTAGCAGTTGGATATAAGGACCTTG AGTAGAGATACAGATTTAGGAGTAATTAGCATATTTATGTCAGTTAAAGCCATGGATGTAAATTGCTC AAAGAGCATATGTAAATTGAAAAGGGGAGAAAATGTAACCCTGATAAACATTAACATTGGAGGTGCA

[0959] GGCAGAGACTCTCTGTCTCCTTTATGGGCTGGCTCTTCCTAAGTCTAGCCCCAGATAACTAAGAACA

[0960] AGTGTTGCAGAAGCCAAAGGAAGAAAAGGGGTTTCAAGAATACCAAAGTAGTTGGTGTCAGTTGCCA

[0961] TTACGATTCAAATGAGATAAAGACTGAAAGGACTATCAATTTTGGCAATTGAAATGTCATCTTTACTTC

[0962] ATTGAGAGCTGTTTTAGAGGGCCAGTAAGAGGAGAAGGCAGCAGGTGAGGAAGTAGGATTAAGTGT

[0963] TAATTTTGAGAAGCTTGGCTGTGAAGGAATGACAAAAGAGGATAGCTTGATTCAGGGTTGAGGGACA

[0964] ATTTTTTTTGGTTTTTCGGGTTTTGTTTTTGTTTTGTTTTGTTTTTTGAGATGGAGTCTTGCTCTGTCAC

[0965] CCAGGCTGGAGTGCAGTGGTGTGATCGCTGCTCACTGCAGCCTCCACCTCCCGGGTTCAAGCAATT

[0966] CTCCTGCCTCAGCCTCTCGAGTAGCTGCGATTACAGGCTCCCGCCATCATGCCCAGCTAATTTTTGT

[0967] ATTTTTAGTAGGGTTTTGCCATGTTGGCCAAGCTGGTCCTGAACTCCTGACCTCAAGTGATCCGCCC

[0968] ACCTCCGCCTCCCAGAGTGTTGGGATTACAGGCGTGAGCCACTGCACCCAGCCAAGGGACAATTGT

[0969] TTTTAATGTAAGAGACATTAGTATATTTGTAACTGGAGAGGAAGAAGGCAGTGAAGAGAAATTGAAGA

[0970] TAACAAGAGAGGAAATGATTGATGTAGTAAAATTCCTTGAGCTTGGAAATTATGTCTCTCAGAGACTG

[0971] TGAAGAATTAAAGATGGACATAGCCAGCTCTGTAACTCTTTACAGACTGTGTGATGTTGGGCAAATTA

[0972] TTTAATCCTGGGGCTAGTAGTGTTTGCCTTCCATAGTGGTTTGAATTGCTTATTATGCCTGGTACATA

[0973] ATAAGAATTCAGAAATTATAGCTAATATTAATATGCAAATAGTTATAGATATTAGAGCAGAAAAGTTGT

[0974] TTGATGGCTTTTGTTTTCTCTATTATGATGAAGGGAAGGGATGTAAGTAAGAGAAGGAACTACAAAAG

[0975] AGTGGGAAAAAAGTTGAAATATCCAGTTTTCAAATGCTAGAAGAACCTTTGTAACCTAGAATGAGTAG

[0976] AAAAGATTGTCAAGGAGCTTTAAGAACACATTCGGAATTTAAAAATCTAAGTTTATGTTGTTACTAGCA

[0977] GTAACTTGTAAGAGTGGAGAAAGCAAAATTTGGTTAATCCATAGTTGTGGAGAGTTTCAGAGCTGAT

[0978] GCAACAGAAAAGAAAGGGATATGGCCTTTGTCTTGTAGTTCCTTCCACCTGAAAGACTCTTTGCTTTT

[0979] CTACATGCCTATCTCTGAAACCCCAACTCAGAGTAATTCCTTGACTGCTTTATCAGTGACCAAGTCCT

[0980] ATAGTTATCATACACAGCACTAAAAATCTTATCGGCTGGGTGCAGTGGCTCACACCTGTAATCCCAG

[0981] CACTTTGGGAGGCCAAGGCAGGCGGATCGCCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACA

[0982] TGATGAAACCCCATCTCTACCAAAAATAAAAAATTAGCCGGGCATGGTGGCAGGCGCCTGTAATCCT

[0983] AGCTACTCGGGAGGCCGAGGCAGGAGAATCGCTGGAACCCAGGAGGCGAAGGTTGCAGTGAGCTA

[0984] AGATCGTGCCATTGCACTCCAGCCTGGGTGACAAGAGCAAGACTTCATCTCAAAATCTTATCACCTG

[0985] TATCACTTAGTTGGCAATCAATTGAGCAGCAAACTTTGGCATCTCTTTTATTATATTCTTATGCAATTAT

[0986] TCTTAAATTATTTGATTTTCACTTACTTCCAATGTGTGCATCTTACTTCCCATGAGATTGTAAGCTCTCA

[0987] AGAATGGAAAGTTAATGACATCACTAGGATTTTTATATTTGTTAGTAGCCATATAACTCCTGTCACCTT

[0988] CTTTTCAGGTACGTATTTGATTTTTCTGTAGAAAATGTTGAAGACTTTATATGATACATTAAACATGATA

[0989] GAAATACATCTTTAAAGAATTTACTTTGTTTTAGCCTGTAAACAAAAAGTTGTCTATTTGCAGAGACTA

[0990] TTCAGAGATATTTGGGGCCATTCAATCCCTCATATTTAAGTTAAACTAAATAAACAGACTAATGCAAGT

[0991] TCTACCCATCAAGGCCCAAATTGCATTACCAGTAGCGACTGTCCCCACTACCATCGTTGTTATAAAGA

[0992] GCTAAATATATATATAGTTTTTTTTTTGTTTTTTTTCTGTGATGGAGTCTCACTCTGTCACCCAGGCTG

[0993] GAGTGCAGTGGTGCAATCTCAGCTCACTGCAACCTCCGCCTCACAGGTTCAAGCAATTCTCCTGCCT

[0994] CAGCCTCCTGAGTATCTAGGATTACAGTCGCGTGCCACCATGCCTGTCTAATTTTTGTATTTTTAGTA

[0995] GAGATGGTGTTTCACCATGTTGACCAGGCTGGTCTCAAACTCCTAACCTCGTGATCCACCAGCCTCA

[0996] GCCTCCCAAAGTGCTGGTATTACAGGCTTGAGCCACCGCACCCGGCGCATAAAGAGCTATATTTTAA TAATAAAGACAAATTTTAGTGGCCGGTTGCGGCGGCTTATGCATGTAATCCCAGCACTTTGGGAGGC

[0997] TGAGGTGGACGGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCGT

[0998] CTCTACTAAAAATACAAAAATTAGCCAGGCATGGTGGTGCGTGCTTGTAGTCCCAGGTATTCAGGAG

[0999] GCTGAGGCAGGAGGATCACTTGAACCCAAGAGGCAGAGGTTGCAATAAGCCAAGATCACGCCACTG

[1000] CACTCCAGCCTGGGCGACAGAGCAACTGAGTCTCAAAAAAAAGGACAAATTTTAACAAAACCTTTCT

[1001] ATGAGCCACTTTGTTTCTTTCCTCTTCTAGTGTGCCCTTATCCATCCATATTTTTATGATTGTAACCAG

[1002] TGTACTTTTAATTTTATATTTTTAAATTATACTATAAACATGTTTCATGATTCAAGCTTCATAATTATTTT

[1003] GGTAGCTGCATAATACTTCATTAAATTGATACACCATAATTTTCTTAACCAAAATATGTCAAAATGCCT

[1004] ATAATAGAGAAATAATTATTTATAACTTTTTAGTATGATGGATAATGTTGCACTAAACATCTTTGTGCAT

[1005] ATCACTTTTTCTTCTGAATTATTTCCTTAAGAAAAGTTCCCAGAAGTAGAATTACAGAATCAAAGGATA

[1006] TGAACATTTTTATCTCTCTTAATGTGCACCAGTATAATTTTTTTTAAGGATTGATGAAGCCATTTTTTAA

[1007] AAATTTATTTATTTCCAAAGTTCAGGGGTACATGTGCAGGATGTGCAGGGTTGTTACGTAGGTCAACA

[1008] TGTGCCACAGCGGTTTGCCACACAGATTATCCCATTACCTCGGTATGAAGCACAGCATCCATTAGTT

[1009] ATTCTTTCTGTTGCTCTTCCTCCTTTTACCATCCACCCTCCAACAGGCCCCAGTATGTGTTGTTTCCC

[1010] CCATGTGTCCACTTGTTCTTATCATTCAGCTCCCACTTATAAGTGAGAAAACACAGTATTTGGTTTTCT

[1011] GCTCCTGCATTAGATTGTTGAGGATAATGGAAGCCATTGGTTTTGAATGGCCTGAAATGGACATCAA

[1012] CATTTGATTAGGACTAATAATTGTTTCATTATAGGTTTACATTGGCAAGTGCTTCAAAATTTAGATTGT

[1013] ATTATGTTCACTAGATAATTCCAAATTGTTTTGTGTAATAGTTATAAGATGTATTGTTTTAATTAATAAA

[1014] ATAATTCTTTTAACGTTAGTGGAAAATTCAGTGTTATCGCTACTCTCTGATTATATGCTTGCTTGGAAT

[1015] AAATATACATTACTATTTATTTGTAGGACTTGATTAGAGACCAAGGATTTCGTGGTGATGGAGGTAAG

[1016] TAGTGATTTCAGGTTTTTTTAAAAACTCAAGGAAACTGCAATTGCTTTGCTGCTTATTTCCTTTATACTT

[1017] GCCTCTTTCAAGTAACAGACACAGAGAAAAATGTGTAGAGAAACCCAAAATTTTTTTGTTTTTCTGTAG

[1018] TGTTTGTCATTTACCTCTAATAAAATGTTAACTAGTTTATAACATGAGTAGAAAAGATGACTGGACATA

[1019] AAAGGAAGTCTTTTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGTTGGAGT

[1020] GCAGTGGCGCGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAG

[1021] CCTCCCGAGTAGCTGGGACTACAGGCGCCTGCTACCACGCCCGGCTAATTTTTTGTATTTTTAGTAG

[1022] AGACGGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCGCCTCG

[1023] GCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCCGGCCAAAAGGAAGTCTTAAAATG

[1024] TATTATCTACAGTTTTAAAATTTCTTCCAGGATCAGACAAGATCGGACACGTTCAGGATGGTATGGCC

[1025] GTAGACTACAGTTTTAAAATATCTTACCAAGGAAAGATCCTTAATTTTTATACCCGCTTTATTAATTTCT

[1026] AACCATCTTGAAAGCTATTGTTGATAAATTTCCTTTGTGGGGCTCCACTGATACTTAAAGATTGACCTT

[1027] AGAATCAGATAAAACTTAACTTTGCTAAATCATTCTGAAGAGGGGGTTTGTCAGACATTATCAACCAC

[1028] TTCCTTCAACTTTCTGGAAGTGTTTTAAATGTACATTTTATAGAACAGACCCATAATGGCAAAGCCCAT

[1029] TTGTCCTCTTCTTAGGTCAGTAAATACACAAATGAGAAACTGAATTGAGATTTCCAACTGAATTTTCAT

[1030] CTAGTATTCACTCTAGCACATAAGACAACATTGCTTAAGAAAATACTTTTTGTAAGCATTACCCTATAT

[1031] AATGTTTTATAAGAGGTGATATTTGAGACTGTCTTGAAGTGTTCTTCCAGGAGGTCCTTTACACTTAC

[1032] CTTCCCTGTTGTCTTCTGCCTAGTAAGGAAGACCTGTAATAACTGCTTATCATGCTTAGAGTTGACCT

[1033] CTTCACTGTGACCTTCTTTATCTTCAAAATATCTAAGCCCAGACTCAACAATATTTTACATTGAGTAAA

[1034] CATTGTTATAAACCTTCTTTTGTTATGTTTCTGTATACCCATGAAGCAACCAAAATAATAATAAGCCTG CATTCTATACTCTGGACTTGGTATTGATGTTAGCACATAGTTACACAAGCTTTTTTTTTCCTGTTTGTT

[1035] ATTTCATGAACCTGCCAATTAATGTTGCTGCCAGTTTGACTTTCGTATGTCTTAATAGCTGTGGCTTTT

[1036] GATAATTTTGCCTAATACATCCAGCATTTAAATGTTGCCATCATGTTAGCATCACAAAATTAACTTAGT

[1037] CATAAACACAGCCTGCTTAGTACCTAAAAGCAAGTGGCATTTCTTGTCCTTTTCATGAGTCACTTTTTA

[1038] AAAAATCATTGGGATTTTATGAAAATAAGCAGATTTTTGGTCCAGAATTATTTTATGAAACAGGCTTCA

[1039] ATTCATCTTGTTTATTCCCCATGACTTCTTTCATTTCTTCTGTGTGTCTGTCTTCCTGTGTTTGCCTGC

[1040] CCCTCTCTTTCTCTTCTAACAGCCCCTTTGAACCAGCTGATGCGCTGTCTTCGGAAATACCAATCCCG

[1041] GACTCCCAGTCCCCTCCTACATTCTGTCCCCAGTGAAATAGTGTTTGATTTTGAGCCTGGCCCAGTG

[1042] TTCAGAGGTAGTTGGGCTCTTCTTTCTTGTTTTCACCCAAAGCAAACTAAATATAAAACTACAGATGCT

[1043] GTTTGTGCCTCACCCTCACAGCGTGTGTTTGTAAGTGTGAAAGTTTTCAGTACTAAATTTCTGTTTGG

[1044] CCTGGCTGGAATGCTTTGAATGTACGTCTCACACGTACTCACTGCCACAAGCTTTCTGTATGCTGTCT

[1045] GTCATAAATTTTTAAAAGCAAGAAAATCCTGACCTGAGATTTCCATCTTGTTTTTTCGTTATTTTATTAC

[1046] TTCTTGGTCTTGATAATTTCTTAAACTTAGTGGGTGGGAATAAATAAGGTGGGTGGGGAAGAGCTTAC

[1047] TGGATTCCTTTGATTTTAATGCATTTAAGTGATTATTCTTGATGACTTAATATTTGTTAATTTTGTGGTT

[1048] TTTAAG AAAATTAAAGTGTCAATG G AAACTTCTATTATG AG ATTTTATTAG GCTTTTG G CCTTTTTTCAG

[1049] ATTCTGTAATACTAGCAGTGTTTTTTGGGTTTTTCTTTCCCCCAATATGGGATGTGTATATTTTTGTCA

[1050] AAGGTAGGGAGCTGTTAAAAAAGACAAAAAAAAGATTTATAACATATTTTAGATATTTCAGTGTACTTC

[1051] AGAAATTTGAGAATTTATCCTTTTAATTATGTCCTAATAGAAGAAAGTTTACAGTATAATTTCATTCTCC

[1052] CATTTCATCTTGCCATGTTTTATTTAGTAGTTAAACTGATTTGTAAAAACTTAAGTCGGGCCAGGCGC

[1053] GGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGATGGATCACCTGAGGTCAGG

[1054] AGTTTGAGACCAGCCTGGTCAATGTGGTGAAACCCCGTCTCTACAAAAATACAAAAAAAATTAGCTAG

[1055] GCATGATGGCGGATGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCTGGAGAATCGCTTGAACCC

[1056] AGGAGGCGGAGGTTGCAGTGAGCCGAGATCACACCATTGTACTCCAGCCTGGGTGACAGAGCAAG

[1057] ACTCCATCTCAAAAAAAAAAAAGTAAAAATTGGGACAGATGTCTTTCTCTAAATATTTTTAAAGATTTAT

[1058] ATTTACTGACTCTTGCTAGTTAGTATCTGTTATATATTCTGAATGTAGTAATGGTGCTTTAGATTTTTGC

[1059] TCTCTCAGCCCTGCTGTTTCTCAGAAAATCCATAGAATGGGATGGAAGTCATACAGTAGTGAGTAATA

[1060] CAACTAAATTAAGTGATACAATAAAACTACTTAGTAGATCATAACCGTGAAGCCTGGTCAAGCAGTCG

[1061] AGGCTTTATAATGTTGAAAATTATCAATGGAAGGTAGAAAATGGATTGTGCTCTACTTAATAGACATTG

[1062] TGGATACCATTTTATTTTAGAAAATTGCATATGAGATAATGAAAATTCTACATGGTGATATAATATGAT

[1063] GTAATAATGGTAAACATTTTCTACAGATTAAACATTTAAATGTGGTTATTGGTATCCTTGTTATCTGAAA

[1064] GATAGTGGCTCTTTTTTTCCTTAAGAGTAGCAGTCATTTTTTAAAAAGAATCTATTTTCTTGAGGTCAT

[1065] TTTGTTGTTCTGTATATAGAACTATTGCCTGGACATCTGAGTTCTACTCAGCTGTATTCAGGCCCCAG

[1066] TAAGATTCACTGCCCTGAACTCTTCTGAACCAGGTGCTACTGTACCTTAACTCAGGATGTTTGCCATG

[1067] AGAAAGGTATGCAACCCTGCCAACAGAGATCACTTCCAAAGAGTATACTCCTCAGGCTCACTTGACC

[1068] TATAG AATATTTGTATTTATAGTAACTTG G CTG AG AG GCCATAG CG CTTACTTAACAAAG CTCTCACTT

[1069] ACAAAGGCAGAGATTTTTCAGAAAGTCTTGAGAAATATGCCCGGCTTTATTTACATTAACTTTGTTTTG

[1070] TAGGTAACAAATAATCTTTGTTTAATAATGTAAGCCTCCAGGAACCAATGATACTGACCAATATCTCTT

[1071] AAATAGTAGAGCATGTAGTTTAGGATTATATTTGAGTTTAGTGATTAATATGAATAAGTCAGATATTTT

[1072] CAACATTATGGCCATTATTAGAAAATGTTTCCATCTGGGGATTTCCTTTTTTTTAATATTGATTGGCTG TTGAGGTAATATTAAATAATTAATTAAAAATGTATTTGTTATATAGGCTTTTACATTTATTTTGCTTTTTG

[1073] ATTTTTTTCATCAAAGAAACAGAAACTTGGGAGTATTTTTAGTATTTCTGTCTTGTTTTAGAGAGATTGT

[1074] TTTTCTCCTAGATTTTGCACCAGTAAATAAAGTATGTGTCTATGTCTATCATCAGATATCTTAAAGGTC

[1075] ATTAAATTGGCCAGAAAACTAAAAGAAATTATAGTTGTAATCACCAAATGAGGCCCCTTTTTGGCCCA

[1076] TCCTTTCCAAAAGGTCTATATTTAAACATGCACTACATTTTAAAATTAAGTCTAAATATCCCCCAACCTT

[1077] CTACCCCTGATAAATTAACATACTTGCTCCTCCTTAATGTATACATTTTTCTTTTCACTAATTTAGGATC

[1078] AACCACAGGTTTGTCTGCTACCCCCCCTGCCTCATTACCTGGCTCACTAACTAACGTGAAAGCCTTA

[1079] CAGAAATCTCCAGGACCTCAGCGAGAAAGGAAGTCATCTTCATCCTCAGAAGACAGGAATCGAATGG

[1080] TAAGAGTATATGATATCTTTTTTTCTCTGAATTCTTTCTTCTTAGAAGTCACAGCCAAATGTAATATTAT

[1081] CCTTTAGATATATTATGTCCATATGTGACACAGAATTCCCATAATTAAATAAATTTAAGAACTGATAGTT

[1082] TTTTGCTTAAAGCATATTTCTACGGCACTGCTTTTTGCTGTCATCTATAATATAATTTAGTAAAAGGCA

[1083] GTTTTGGAAGAGTAACAGTATTCTGTTCTAAAGTAAGGAAAAAGAGAGAAAGCTAATATTAGAAGGCA

[1084] CGAAAAGGCTGGTCCAGAATTCAGATATTTCAGATATCTACTGAAGGACATTCTTCCCTATTTAAAAA

[1085] ATCAACTTTCTTCTGCAAAATGAATCCACCATGGCACATGTATACGTATGTAACAAACCTGCACATTC

[1086] TGCACATGTATCCCAGAACTTAAAGTAAAATTTAAAAATAAAAAACGAATACTGTTTAGCCGTAGTATT

[1087] GCTACTAATTGTTGAATAAGAGGATCTTTTACCCTACCAAAGTAATTTTATATGTTGATTTTTTTTTTTT

[1088] TTTTGGAAAGACCGAATTAGATAAGATACATGAAGAAATTTAGCACTGATTGAAAAAGACTACCTAGA

[1089] TGAATTGTCAGTAGTTACCACAGGTTAACTTAAAATTTTTTGTGATTTAGAGCCAAAACTATTCACAAA

[1090] TATAGCAGCACTTATCTTGCTCCTTAAAGTCTTCCAGATGATAAAAACATTTTACTTATTTCAGTAATAT

[1091] ACATTCCTGCTCATACCCCATAAATAATTTATATTTTTTAATAAATTGTTTCCATCCTAACCATCCTTCT

[1092] GAGCAAAGTATCACAAGGACAGAAAACCAAACACCACATGTTCTCACTCATAGGTGGGAATTGAACA

[1093] GTGAGAACACTTGGACACAGGGCAGGGAACATCACACACTGGGACCTGTCATGGGGTAGGGGGAG

[1094] GGGAGAGGGACAGCATTAAGAGAAATACCTAATGTAAATGACAAGTTAATGGGTGCAGCACACCAAC

[1095] ATGGCACATGTATACATAAGTAACAAACCTGCAAGTTGTGCACATGTACCCTAGAACTTAAAGTATAA

[1096] TAAAATAAAAAATAAAAATAAATTTTTTCCATCCTAATATTGACTTCAGTCTTAAATTTAAGTTTTGTATT

[1097] TTAAGAGTCATACTTTTAACTACTATTCTTCCAGAGAATTTTTCTTAAGGGGATCTCTTCCTGTATCCC

[1098] TCTCAGGCATAAGGTAATGTACTTAGGGTGAAACATAAGGTTTTCTTTTTCTGTTTGGCTTGACTTGA

[1099] CTTTTTTACTGTTTTTATCAAGAAAACACTTGGTAGACGGGACTCGAGTGATGATTGGGAGATTCCTG

[1100] ATGGGCAGATTACAGTGGGACAAAGAATTGGATCTGGATCATTTGGAACAGTCTACAAGGGAAAGTG

[1101] GCATGGTAAGTATGTAATGTGGTGACATTGTGACAAGTCATAATAGGATATGTTTAACAACTTTTATTT

[1102] TGTAAAAAATATCATCAAAGGAAATATTCACTGTTCGCATCAATAAACTATTTTGATTAGTTTCAGGAC

[1103] TCCTCCAAAAGTTTCTAACAAAAATTATGGGAAATAAAAACTGTTCACAGCAGTCGGGACTCCTACCA

[1104] TTTTATTACAGTAATAATTTTTAAAGGGGAATTCCTCCAGGTTAACTAGTCCTCAAAAGGATTTTATTTT

[1105] CTTTTAGAGTCTTTCAGCTGATAATTTTATTTGTATTATAAGTCACAAGTAAACATATTAAAAATGTACT

[1106] TAATGGCTGGGCGCAGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAAGCTGAGGCTGGCTGATC

[1107] ACGAGGTCAGGAGATCAAGACCATACTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAA

[1108] AATTAGCTGGGTGTGGAAGCACGTGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATC

[1109] ACTGGAACCCAGGAGGCGGAGGTTGCAGTGAGCTGAGATTACGCCACTGCACTCCACCCTGGTGA

[1110] CAGTGAGACTCCGTCTCAAAAAAAAAAAATTAACAAAGAAATATAAGTGGCCAGTAAACATATACAAA ATGTTCAGCCTTACTAGTTATCAAAGAATTGCAAATTCAAAAAATAGACATCATTATTTGCCTCTTAGT

[1111] TGGACAAAATCTTTTTAAATTGGATTATATTAAGAGTAGTGGATGTATTTTCATCAAAGGTTTAATATCA

[1112] ATGAAAAGTGAAAGTGAACATGTATCCAACTAATAGAGAATTGGATAAATTTATACCATCATATGTGAT

[1113] TATATAGGAGTTAAAATGGCATGGTAGAGGTACATTTATTGATGTAGAAAGGTGTCTTTGGTATATGA

[1114] AATTTTTCAAAGCAGTATGTGTAAGATACCATATTATGGAGCTCATAGAAATATATAACATAATTTTTTA

[1115] TATGACAGTATTTTAGGCCAGGCACAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAG

[1116] GCAGGTGGATCACCCAAGGTCAGGAGTTCGAGACCAGCTTGGCCAACATAGTGAAACCTCATCTCT

[1117] ACTAAAAATACAAAAAATTAGCCAGGCTTGGTGGTGGGCGCCTGTAATCTCAGCTACTCAGGAGGCT

[1118] GAGGCAGGAGAATTGCTTGAACCTAGGAGGTGGAGGTTGCAGTGAGCCGAGATCCCGCCATTGCA

[1119] CTCCAACCTGGATAACAGCGAGACTGTCTTAAAAAAAAAAAAAAAAAAGACTGTGTTTTAGTTTTTATC

[1120] TCCTTAATCTATCTTTTCACAGGTGTTCATAAATATTCACACTAAATTCATGTAAAAGCCTAATAACATA

[1121] TAATGTCACTTTTGAGTGACATAATTAAGGGAATTTTTTTATACCTTCAAAATGTCTTTAAACTTTTCTT

[1122] AAGTGCTGTACAGTATTTTATGATACAAACAGTAGAATAAGCACTGTATTACTTTGATAATTGAGGAAA

[1123] ATCAATGTTGATTTAACTTATTAAAATATACATACAGGTTGAGTATCTTTATTTATTTATTTTTGTTTGTT

[1124] TTGTTTTGTTTTGAGACAAGGTCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCACAATCTCAACT

[1125] CACTACAACCTCTGCCTCCCAGATTCAAGCAGTTCTCCTACCTCAGCCTCCTGAGTAGCTAGGATTA

[1126] TAGGCGCGTACCACCACCCCTGGCTAATTTTTGTATTTTGAGTAGAGACGAGTTTTGCCATGTTGGC

[1127] CAGGCTGTTCTCAAACTCCTGACCTCAGGTGAGCCACCCACCTTGGCCTTCCAAAGTGCTGGGATTA

[1128] CAGGTGTGAGGCAGCACACCTGGCCAGGTTGGGTATCTTTAATCCAAAATCCCAAACCCGAAATGCT

[1129] CCAAAATCCAAAACTTTCTGAGTGCTGACATGATGCTCAAAGGAAATGCTTATTGGAGGATTTCATAT

[1130] GTTTGGATTAGGGATGTTAAACTGGTAAGTATAATCAAAATATTCCAAAATCAGAAAAAATTTGAAATT

[1131] TGAGACACTTCTGGTCCCAGGCATTTTGGATAAGGGATACTCAGCCTGTGTATAAAAGTGCACATAA

[1132] ATTAGCCAGGCATGGTGGCATGTGCCTGTACTCCCAGCTATTGAGGAGGCTGAGGTGGGAGAATGG

[1133] CTTGAGCCCAGGAGTTCAAGGCTGCAGTGAGCCATGATCACACCACTGCACTCCATCCAGCCTAGG

[1134] TGACAGAGCAAGACTCTGTCTCTAAAAAAATTAAATAAACAGAACATTACTAGCACTCTAGAAACACC

[1135] CTCCCATGTCCTCTTCTAGCCAATCACCTCTCTCCCAAGGGTAACCACCACTGTGATTACAACAGGA

[1136] AGTGCATAGTGTGTACTCTTTTGTGTCGGCCCTTTTCACTCAACATTGTTTATAAGATTCATCTATATT

[1137] GTTGTGTGAAGTTGGAGGTCATTCATTCTCTTTACAGTATTTCATTGTGTGACTATAACATGATTTCTT

[1138] CTTTCATCTGTTGCAATTGGATCGTTTCCAGTTTGGGGCTTTGATTGATGCTGGTGCTGTAAACATTT

[1139] TTAGTGTATGTCTTTTGGTGAACATGTAACCATTGATGGGTATATATACCTAGGACAGAATTGTGAGA

[1140] CCACAGGGTATGCATATGTCCAGTTTTAGTAATGCTGCCAACAATGTTACAAAGTAGTTGTACCAATT

[1141] TAAACACCTACTGGCAGTGTTGACGTTACAGCTGTTTCACATAAAGTTTTTTTTTTTTGATGATTTTAAT

[1142] AAAATATCATTTTCTTTTTTTATTATTATTATACTTTTAAGTTTTAGGGTACATGTGCAAAGTGTGCAGG

[1143] TTAGTTACATATATATACATGTGCCATGCTGGTGTGCTGCACCCATTAACTCACATGAAGTTTTTTTTA

[1144] AATTTTAGTGACAGTTTTAGTCATTTTCCTAATTGAAAGTATCATAAGTAATCCATAAATTTGAAAAAAA

[1145] TGTTAACTACTCTGATAAAAAAGTTTTATAGTTTCCTACTTTTAAGCAAAATTCCATAGGGCCTGGTAA

[1146] TTGTAGTTTCAACATTACTTGCAGTTTCAGTTAGTAAATAAATATTAAGCCTAGTAAGTATAATTTAATA

[1147] TTGTCAAATAATTTGGAAAATACCATGGGTACTTAATTGATTTTACCAAATTTCCATGGAACAAACAAG

[1148] GTTGGCTATTTTTTGGATTGATATTTTGAAATACTAGTACAGGAATATCATTGTTAGTTGAATTTTTAGC CTTAGAAAACAAATGGAGTTTAGATAGCTAAAGTATAATTTATTTGTGATTTAATAATGGTATGGAGTT AGGGCTATGATAATTAGTGAAAACACCCAAGAATGTTTTATACTTTTAAATTTTAAAAATTGAAATGAC ACTTGGAGTAACAATTGCCTTTTAGGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCACCTACAC CTCAGCAGTTACAAGCCTTCAAAAATGAAGTAGGAGTACTCAGGTGAGCTTGTGTGAATTACTCTTTT CCAGAGAAAGAAGTTATTTTTATTAGCTCCTGGTTCCCAGTGGTAGCAACTATTAGCTTTACAGATTT ACTCAAAATGAATAAATTTGTAGAAACAGAGTATGTCTGAGTATATTTTTGTCTTTAACCACATTCTTTT AAGTAGTATGCAATGTTATATGGTATGGCTGATAGAATACTTAGTCCTAGACTGAATTAATGGAAGTA TAGTATTCTGATAATATAAAGTAATAGTTCTACTTATGAAAAGAATACTCTCCAGTTTTAAGCTTATCAG AATACATTTAGAGGTGGTATTTAGTCCTGGGCTCTGGAATTTTAGAAACATTGACAAACTAGGATATG CCTAGTGAGGACCACCTAAATAGGGAAGATTCTAGAGGTGTAACGGGGGAAAATAATCAACAGAACT GAGGATATTTAGTTCACAGAAGGCTGTTATGTTCAAGAGAGTGCACAGTTATTCCAGAGTGCGGAAA AAAAAGTTATTCCAGAGAGCAGACCAGGGAAGCAAGCCAGAGGTGAAAGTTGTAAGAAAATGATTTT GTCTCAACACTTGGAAACTTTATAATACCAGAACCACTTAAATAAAGATATGAGAGTCAGCTACAACT GAGTGATGAACTTCCCATAGTTGAAGGTATTTAAGCAACCTCTAGTTGCCTGTCAGATATATTTAAAA AGATATCTCTGCATAAAGTAGGAGGTTAGACTTGGCAATTGCCAGTCTCTTCTAAATGTATCCTTTTG TTGCCTTTTTTAAAAAAAAAAAAGCTTTTTCTGACAACATTTTACCGACAGACTACTTTGGTTCTCTTTT GTAAGAATTGCTAAAGTTTGTCGACATTTAATGTTTACTGTCACATTTCTTTGTACAGGAAAACACGAC ATGTGAATATCCTACTCTTCATGGGCTATTCCACAAAGCCACAACTGGCTATTGTTACCCAGTGGTGT GAGGGCTCCAGCTTGTATCACCATCTCCATATCATTGAGACCAAATTTGAGATGATCAAACTTATAGA TATTGCACGACAGACTGCACAGGGCATGGAGTAAGTTCCATTCGTTAAATGTCTTGTAAATTATTTTT GAAGACCATTGAGGATGTTTTAAAGGTTTTGGCTGCTATTCTTTTGGATTGCATTTTAAATTACTGTCC AGGAACATAAGGATGCTAACTAATGGCTGGTAAATAATATGATACTAAAAAATAAATGTCTCTGTCTA GTG CAG CCTTCAG AACATATATCAAGTATTTG ATAATAAATACATG ACTG CAAACTTAG GCTTAGCAC TCAGTGATTGAGCTAAGCAAGAGAGGTTCAGAAGATAGAAACAGCAAAAACCTGCTAAAAAGTTGTT AGCAGTTGTGCAAGTAAACAGAATGGTTGTTAGTTACTTTTTCAAATCAGTTTCTCTGAGTGCCCGTA TTTTTGGTTGCAAAATGGTCAGTTAATAAAGTTAAAGTGAAAAATCTGCATTCTGACCCTTTTTGAGGA TTTCAGAGTGAGTTCCTATCTGTTGAATTTTGCTATGCAATTTAAGGAGTTATTTTATAAAGTTTACCAT AAGCTAATATG GG G AACTG ACTTTG AAG G ATAAATTTTAAATTTTG CAACTCTTAAGTG CAAATG AATA GGTAAATTAAAAGGTAAAATTAAACAAATTTTGAAAGCACTTAGGTGAAAATTATAAACTCAGTAAAAT ATGAATTTGAAAGCTCTGTGAGAAGTTTAAAAATAGATATGATCTGAATTTTGTTTTTTACAAATTGCTT TCACTTACATAGATTATTATGTCATTTAATCTTTATAATGTTATGAAGGAGATCTTTTTTCTTTTTACAG ATAAGGAAATTGAGGCTTTTAAGTTCCTTGTCTAAGGGCACACATTTAATAAGTGGCACCAAAGGTGT TTAACTCAGGATTTCTGACTCCCAATCCAGTATTCTTTCCCCATAACCACTATGCTACTTTTACATTAC AAAATTAGAATAAAAGAGTAAAAGGGTATATATGTACTAACACCTACAACTCTAACTGAGTATTGCTCC TAGCAAGTAAGTATAGAGCCAAGACTCTAAACCAGATCTGGCTCTTAGATCTTCCAACTATACCACCT TCTCTTTCTCAAAACTAGGCAATATATCTATAATTTAGATTGTTTACAAGCCTATATTCGGCCAAAATA CTTATTACAGCAAATTATTACCTTATTCAGTAACACCCCCACTTACCCCTAGACTTGAAACAATCTCAA CGTTTCAGATAAGTTAGAATCTCTGAATCTGTTCGAATCTAAAGGCTTTTAAAGAATTAAAATCTTGGC CAGGCACAGTGGCTCACACTTGTAATCCCAGAACTATGGGAGGCCGAGGCAGGCGGATCACCTGA GGTCGGGAGTTCAAGACTAGCCTGACCAACATGGAGAAACCCCGTCTCTACTAAAAATACAAAATGA GCCAGGCACAAGCCTGTAATCCCAGCTACTTGGGAGGCTAAGGCAGAAGAATCACTTGAACCCGGG AGGCAGAGGTTGCAGTGGGCCAAGATCACACCATTGCACTCCAGCCTGGGCAACAAGAGCAAAATT CCGTCTCAAAAAAAAAAAAAAAGAATTAAAATCTTGTGAAGAGTAAACCATGGCAAAGATTGTGAACA TTCAGTG AG AAACAAAG G CTTATTCTCTTCCC ACACCACTGGTCTCTTTG CAATTTCTTCAG CAGG CC AAGCGTGTTCCTTCTTTAGGACCTTTATGTTTGTTATATTCTCTTTAGGATACACATGCCACAAATATC CTTGTGTCTCGGTTCATATGTCCCCTTTTAATAGAAATCCTTGCTCACCTTATATAACTAACATGTCCC CACGTCACTCTGTCACTCTCTATACCCATAGGCTTGATTTTCTTTATAACGCATAGCTCCATCTGACTT GTTTCTTGTCTTTTATCCCCACTAGAATGCAGGCTGTATGAGAGCAGGGGCTTTTTTTCATTATTTTAT GCCTAATGCCTAGAATGGGACCTGGCATACTCAGTACATAACTGTTAAATGAAAATGATTACACACAA CTGCATATTATTGATAGATTTACCTTTCAGAAGAAAGAGATGCCAAATCCTTCTCACATCACAGCTGA GAAATGTGGCTGGGCATGTTGGCTCACACCTGTAATCCCAGCACTTTGGAAGGCCAAGGTGGGAGG ATTGCTTGAGCCTAAGAGTTCAAGACCAGCCAGGAAACATAGGGAGACCCTCGTCTCTGTAAAAAAT AAAAAATTTAGCAAGGTGTGGTGGCACTTGCCTGTAGTCCTAGCTACTCACTAGGCTGAGTTGGGAG GATCACTTGAGCCCAGGAGTGTGAGGATGCAAGGAGTCGTGATTGTGCCACTGCATCCAGCCTGGG TAACAGAGCGAGACCCTGTCCCAAAACAAACAGGCTGGGTGTAGTGGCTCATGCCTGTAAACCCAA CACTTTAGGAGGCCGAGGTGGGTGGATTAAGACAAGAAGTAACAGTAAAGAAGAACATTATCAAATT GGAATAGTGCTGCAGTCTGAAGAACAGTCAGTGAAGAGGTGATATATTTTCAAAATATCACTTTACAG TTTGGGATTATCAGTGTAAACTTTAGTCATCTACTCTGAAACACTTTGGTTGTGTTTTTAAATAGATCT TACCATTTAACATGATGCAATGAGTGTACGATAGTATGAACATAGATCATTCCATTCAGTTTATCCTAG ATTTTAGTAACTGAAAAAGTATTAATTCCAAGTTTTAAGCCCTCCAGCAGAGTATACTTTTTAGTACCA GTTTAAAATTAACCAAGGAGGATATAGTTTCTTTTCTCTTTTTGTTTTGTCTTGTAAGATCATAACATAC AACTGGTTAAATGTACCGACACATCTTCAGTTTCTGAAGGATTTGGCAGGTTGAAACTCCTCTTATTA ACAGGGCTATGAGTTTCAGATTAAGGTGACAGATTTTTGCTCCTTCCTGGAACTCCACTAAAACTGTA ATAAAG G AATTTTTTTTAAAGC ATGG AC ACATAAG G ATG GG G ATAAC AG AG AG G AATG AG ACAATATC AGCAACATTTTGAAAGCTGGAGAGCAGGTGGAAAAGTGATCATAGACTTAGACCCCAAAAGGCTAAA TGATCAGTCAGCAGTGGGGAAATGAAAGCCAACCTGGTTTATACCGTAGAATCCTCAATTCTCAGGA ATTGGCAATATCAGCTATCTCAGGGGATGAAAGGGTTAAAATGAAAGGCCTGTTTGAAAAGCTGTTAT TTCTCTAAATCTGTTCTCTTACTCACCAGGTAACTGCTCCATCCCTATCCTAGCAGTAGACTGGAAGT TTCTTCTCTAGAGAGGGGAAAATAAATATCTCTGGACTGGGAGACCCTAATCTATGTCTAGGACATGT ATATCTTTCCCAAAACATGGGGATTTGATGACTGTGTGCTTACTAAATGATGAAGGGAGATTTCCCCA GCCCTCTCTTTTTATTTGATTCCTGACATGCTAGCAGCCAAACCCTACTCTTCCGAAATGCAGAAGAT TCGAAGAGTCTTGGGTGAATTTTACCAGCTCAAGAGGAAAGACCCAAAGAAAGTGACATCAGGGATT CCACCTAGATTACTGTATAGTTCAAAAATAGCAAGCCCATCTGTATGCTTAAAGCCTCCAGGCAGCTT GTAAGTCCCTCACTTAGTCTAAGTAAGAGTATCGCTGGATAACTAGATATTGGTGGGGAAGTCTTATG CAAATAAGAGAGACTGTAAAACACATAGAGAAAAATAGGCATTGGGAGAAACACATACAATGCAAGA

[1149] TTATCTCTCCCCTGCCTCACCCCACCTCCAAAAAACCTATCAGTTTTCTCAGAGGGAGAAAAGATAAC TTTATGTCCACTAAACAGGAACAGAGGTTTTCTAAGGAACATTCATGTAACAGCAGCAACAAAATGCT AAAATGTTGATATTTACAGTACACTGGAAATTATGTCCTTTGCAATTATTTAAATGTAACTTTTAAATGT TAATTTAAAAGGAGTTAACGTAGTTTCTCAGAATTCTTTTAAGGGGTGTTCAGCAAAAAAAGTTTTAAA ACTATTATGTTAAACACTATATGGTTTAATATTAAATTCCTATATTATGCAACATAATTCGGAAGGGAC ACTTAGATAAATTTTTTACAAACCAAGTTACATAAAATATGTATAATTAATTGGAACACATAACCAGATT GCATCAGTGAGTCTTGAAGTGGATATTCCTGTTTTCTTCTCTAGTGTCAATGACTAAAGCACACTATTT TCACTACTTTTTTTAAATTTTGAGACAGAGTCTCACTCCTCTGTCACCCAGGCTGGACAGGCTGGAGC GCAG CG ACACTCTCTCAGCTCG CTG CAACCTCTG CCTCAAGTG ATCCTCCC ACCTCAGTCTCCCTAG TAGCTGGGACTACAAGGGCGCACCATCACACCTGGCTCATGTTTTTGTATTTTTTGTAGAGACAGAG TTTCGCCATGTCACCCAGGCTGGTCTCAAACTCCTGGGCTCAAGCGAGCCACTGCCTCCGCCTCCC ACAGTGCTGGGACTACAGATGTAAGCCACCAGGCCCGGCCTATTTTCAGTACATTTGATTGAACTTT GTTGTTGTTGTTGTTGTTGTTGTTGTTGTTGTTGTTGTTGTAGTTAAACAATCTGTTTTAATCAGGCTG ACAG ATGTTAG AAC AAAC AGG ATG GTCCTAG G GGTCATG AACTG GTTCTTCAAATCCTAACTGTTG C TGCTGATTTTGTAACAGATTTTAACATATCTTTTGACTTCTGGTCACTCATTTCAGCCTCATGTTTGGT TCTCTGTTTTAATTTCCCCCTATCTATTCCCATGGATCAAATGGCACAGATGGAATTCCTTACATACCT AATTTTTCCTCCCTATTTCCAATACTGTTCATCTTGAATGCCAACCATAGTTTCATCTTGAGGGCTTTG TTTTGGAATTATCTCCAGAAGCTATTCCCAGTTAGAAGCCTGCTTGGATAATTAATATTGCTTCTTAGC TCCCTCCAGCTCTCTTTCCTTCTGTCCCCTGGCTCTACCCTGAGCACAAATGATAATTCTCTGTGACC ATCACAGCCACCATCTTACTGTGCCTCCTTTCAACTCTTCATGTCTATATCCTCTTCCCTGACCAGCA TCATCTCACAAAGGACTGACCAAGCCAGATATAGTCTATAGCTAGACAATAAGGCTATAGGGTATTTA AATAGCCTCTTAATATGTACTTTTGCAAAGCCTTTATTTCAGAATAGCCTGCCCTATGTTGAAAGTGAT CTTTTCTGACTGCTCACCAAAATTCATTCTAAAGTCTCTGGATATAAGCAGAATAGGAACAAACGGAT TCATTTTATAAAGTGCTAAGGTTGCAGTTAACTCATAAGATAAAACCTTTAATAATTAGAAAAGTTAGT CTGGACACGGTGGCTCACACCTGTAATCCCAGCACTTTGTGAGGCCAAGGCAGGAGTATTGCCCGA GCCAAGGAGTTCAAGACCAGCCTGGGCAACGGCAAAACCCCGTCTCTACAAAAAATACAAAAATTAG CTGGATGTGATGGTGTGCACCTGTGTTCTCACCTACTTGGGAGGCTGAGGTGGGAGGATCACTTGA GCCCAGGAAGTCGAGGCTGCAGTGAGCCATGATCGTGCCACTACACTCCGCCCTGGATGACAGAG CAAGACCCTGTCTCAAAAATAAATAAGAATAATTAGAAAAGTTGAATCATTAGGACTTTCAAATGTGTC ACCTTTATTGGATTACAGAATATAAGCAAAAAATGGATAGGTAACATTTTTCCTGTGTGGTTATATCTT CCATTTGTACCTCAGTGAAAAACTATTTCTGATTCCTAGGTTTACTTGAAAAGGAGCAGAGCTGTTCT AATGGTAGATAATTATAAACTCACTCTGAGGAATCAGGGTTGGTAAAGTATGTTTTATCATCTTCTTTT TTGGTTTTTTTTTTTTTTTTTTGAGATGGAATCTCACTGTCACCCAGGCTGGAGTACAGTGGCACGAC CTTG G CTCACTG AAACCTCCG CCTCTCAG GTTCAAGCG ATTCTCCTG CCTC AG CCTCCTG AGTAACT GGGATTACAGGCACCCACCACCACACCTGGCTAATTTTGTATTTTTAGTAAACGGGTTTTCACCATGA TGGCCAGGCTGGTCTTGAACTCCTGACCTCAAGTGATCTGCCCGCCTCGGCCTCCCAAAGTGCTGG GATTACAGGCGTGAGTCACTGCACCTGGCCTGTTTTATCATCTTTTCACCTGCCAGTCATTGATTCAT CCCAAGGACCCAGATATCTTAAGAATACTGTTACTAAAGAAATTCCAGGAATGGTCAGTACATTGTGC CTTTTTTTTTTTTTTTTTTTGGCAGGCCTTATAATTTCAGTATAATATTTATGGTATGATTTTGAATTTAA

[1150] CTTTATCAAAAAATTAAATCACAGAGGCACATAGAAAAAGTTACAGCCTATCGATATATTTACAGAAGC ATTATATTCTCAAAATAAGATGATTAAAAATAATTTGGAGATAAATCCTTACAATTTACTTTGTTTTAAA CAATGATGAGCATGCCTCTTTTACTCATAAGTGAACCCAGTTGAAGATAGAAGGACTAATTAAAGCTG AAAAAATGGTGAACATGTATTAGTGATTGATAATAATTCTAAGTGGCCGAAGAATATTTAATTATAGTG AACATAATTTTCTGGTCGGTAAAAATAATAATAGGGTGCTGATAATAATAATAATCAGAAAATGCAAGG TAAAACAAAAAGGTACCACTTTCCACCCACTGGAATTGGCAAAATGCCTGAGTTCTGATAAGATCAAA TGTTCATAGGATTAGAGGAATTGCTTCCTGGGTCATTTCTGATGCAACCAGCCACCTTAACAGCATTC TGGAAGTAGCTGTTAAAATAGGAAAATGCTTATTCTAACCCCAAGAAACATTAGCTTTTGTTCCAAGT CGTGTATACAGAAAGAGATGTATTATAGGAAACAATATAATAGTGAAAAATTGGTCTGGATGCAGTGG CTCATGCCTCTAATCCCAGCACTTTGGAAGACTAGGGTAATAGGATCACTTGAGGCCGGGAGTTTGA GACCAGCCTGGATGACACTGTGCGACCCTGACTCTATGTAAAACTTAAAACATTAAGGACATTTTTTT AAAAAAAGAAAAACTTATTGAAAAATTGGAAACATGTTCATCAGGAGAAGACTTGATAAATAACATATT GGCACTTACATACAGTAGAATCGTATATAGTAGTTAAAAGTGGATTATATATGTATCAACATAAAGCTT TAAAATATTAATGTTAAGTG AG AAAAG CAAG CTG CAGCATG AG ACCACTTAAAAATTTTTAAG CAG AA CATTTTTTACATTTGGGCTTTAAAAAGTGGTGTGTATGTATATATGTAAAAGTACTGAAATAAGGATTA GAAAGCAAAGATCAAGTAACATAGTGATTATCTCCAGGAATCAAGTACAAACTTTGAAAAAAGACTGG AGGTGGCCAAGCACGGTGGCTCATGCCTGTAATTCCAGCACCTTGGAAGGCCAAGGCAGGTGGATC ACTTGAGGACAGGAGTTCGAGACTAGCCTGGCCAACATGGTGAAACACCATATCTACTAAAAATACA AAAAATCAGCTGGGCATGGTGGCCGGTGCCTGTAATCCCAATTACTTGGGAGGCTGAGGCAACAGA ATCG CTTG AACCC AG G AG ACGG AG GTTG CAGTG AG CCAAG ATG G CACC ACTG CACTCCAGCCTAG G TGACAGAGCGAGATTCTGTCTCAAAAAAAAAAAAGACTGGAGGTGTTTTAGTCCATTTTCTTTACTAT AACAGAATACCTGAGGCTGGGTAATTTGTTGTTTTCTGCAAAAAGAAACTTATTTCTCATAGTTCTAGA GGCTGGGAAGTCCAAGGGCATTGGTGCTAACATCTGCTGGGCTTCTGGTGAGGGCTTTCCTACTGC ATGGTAACATGGTGGAGAAGCAGAAGAGGGAGTGGGCACACACAAAAGGGGCAGAACACAAGGGA CAGCCTCACTCTATAGCAACCCCCTTTCACAGTAACTGTAGAAGTCACTCCTGGCCAGGTGTGGTGG CTCATGCCTGTACTACTAGCATATTGGCAGGCTGAGGAGGGAGGATTGCTTGAGCCCAGGAGTTTG AGACCAGCCTGGACAACATAGTAAGACCTCATCTCTACAAAAAAATTTTTTTTAATTAGCCAAGCATG GTAGCACACTCCTGTAGCCCCAGATACTCTGGAGGCTGAGGCAGGAGGATCACTTGAGCCCAGAAG TTTGAGGCTACAGTGAGGCATGATTGAGTCCACTGCACTCCAGCCTGGGTGACAAAGTGAGACCCT GACTCAAAGAAAAAAAGAAGTCAGTGACTCCTGCTTTCATGAGGGCATTCCTCATGACCCAGACCCA AATGCCTCTTAAAGGTCCCACCAACTCTCAACACCATTACACTGGGGCCAAGCCTCCACATGAGTTT TGTGGGGACAAGCCATATTCAAACTGTAGCAGGAGGCAAATGTATAAAAGTTTTAATGGGTCTGATTA TGGTAAGAATATGAGTGACATTATCCTTTGCTACTGCAGTTTTTTTAAAATTTCAAAATCATGTTACGA

[1151] GGAAATATGTAATCATTATAGGAAATTCAGAAAATGTAAACATAAATAAAAAGCACCAGTAATCCACCA TCAAGAGATAACTGTCATTAATATTTTGATGTGTATTGTGTATCCTTTCAGAATGATGTGTTTTAATACT ATACACAATGGTTTCTTGCTGTTGTTTTAAATCATACTGGGTTTTCCTTTTTACTCTTAAATATCTCTAC TGGTCAATAAATATCTGATACCAGCTCTGCTACATACTGTTAACTCACTGTCTCCCCTTTTTCTTTATG CCAACTATGTTCTGTGGGGTTTCTTAAAATATACTGTAATGTATTTAGCAATGATATGCACTTACTATG TGTCAGACATTCTGTGTACTTTATATACATTACCTCATTTACTCCTCAACAACCCTGTGAGGTTGCAG CTTTTATTATATCCTTGTTTTATGGATGAAGAAACCTGGTTATGGAAGGGGCAAGTAACTTGCCCCAG GTACTTCAGCTCCAGGGTGTATTCCTTTAACCATTAAAGCATGTTGCTTCCCCAACTTATTCAGTCCC TTCGAAAACTTCAAGTAGACCCTTAATGTTATAGGGCAGTTACACTTTCAGTTTCCTAGTTCATTCACT GTCCTCTTTTAGACACTGTCATACCGCCTCAAAACCTCATATCCTTAAGCCTCTAAAACCTCTTCTTCA

[1152] AGAAATCAGCGATGACATTGCTTGCCATCTCTTTAAGACAGTTGGAAGTAACCATTATGACATCTACC

[1153] CACCTGCCTGCATTCATACCAGGTTCTTCTGCCTTATCACTAGTAAAAGCCAATCCCTCCATTTGTAC

[1154] ACTAGATTCCATCCCCTTACCCCTACCCAGAGACATCTTTTGAGTAAATCTCCCATCTTGTTTATCATC

[1155] AGTTTTTCCTTTCCTACTGAATTTTCTCCTATTTTAAAACATCTTTTGGCTGGGCACGGTGGTTCATGC

[1156] CTGTAATCCCAACACTTCGGGAAGCTGAGGCGGGTGGATTGCTTGAGCTCAGGAGTTCAAGATCAG

[1157] ACTGAGCAACATAGTGGAACCCATCTCTACCAAAAAATACAAAAATTAGCCAGGCGTGGTGGTCTGT

[1158] GCCTGTGGTCCCAGCTACTTGGGAAGCTGAGACAAGTGGATCTCTAGAGCCTGGGAAGATGAGGCT

[1159] GCAGAGAGTCAAGATCGCGCCACTGCATTCCAGCCTGGGTGACAGAGCAAGACTCTGTCTCAAAAA

[1160] TAAGTAAATAAATAAAACATCTTTCACTGAGTGCAGTGGTTCACACCTGTAATCCCAGCCCTTTGGGA

[1161] AGCTAACGTGGGAAGATCACTTGAGCTCAGGAGTTGGAGACCAGCTTGGGTAACAGAGTGAGTCCT

[1162] TGTCTCAGAAAACTAAAGTAAAATTTAAAAGTAGGGCAGGTGTGGTGGCTCACACTTGTAATCCAAG

[1163] CACTTTAGGAGGCTGAGGCTGGTGGATCACTTGAGCCCAGGAGTTTGAGACCACCCTAGGCAACAT

[1164] GGCAAAACCCGTCTCTACAAAAAATACAAAAATTATCCAGATGTGGTGGTGTATGTCTGTGGTCCCA

[1165] GCTACTCGGGAGGCTGAGGTTGCAGTGAGTGGAGATTGCACCACTGCACTCCAGCCAGGGCGACA

[1166] GAGTGAAACCCTGTCTCAAAAAAAAAATTAAGAAGTAACAGTAATAATGAAACATCTTTCTTATGCACA

[1167] TTTGGCAGAATGTTGACATTTGTGGAATCTATGTGGAAGGTGTGTGGGTATTCTTTCCATTTTTCTGT

[1168] ATGTTTATTTTCTTTTTTGTTGTTGTTTTGTTTTTTTTATTATTATACTTTCAGTTTTAGGGTACATGTGC

[1169] ACAATGTGCAGGTTAGTAACATATGTATACATGTGCCATGCTTGTGTGCTGCACCCATTAACTCGTCA

[1170] TTTAGCATTAGGTATATCTTCTAATGCTATCCCTCCCCCCTGCCCCACCCCACAATAGTCCCCAGAGT

[1171] GTGATGTTCCCCTTCCTGTGTCCATGTGTTCTCATTGTTCAATTCCCATCTATGAGTGAGAACATGCG

[1172] GTGTTTGGTTTTTTGTCCTTGCGATAGTTTACTGAGAATGATGATTTCCAATTTCATCCATGTCCCTAC

[1173] AAAGGACATGAACTCATCATTTTTTATGGCTGCATGGTGTATATGTGCCACATTTTCTTAATCCAGTCT

[1174] ATCATTGTTGGACATTTGGGTTGGTTCCAAGTCTTTGCTATTGTGAATAGTGCCGCAATAAACATACG

[1175] TGTGCATGTGTCTTTATAGCAGCATGATTTATAATCCTTTGGGTGTATACCCAGTAATGGGATGGCTG

[1176] GGTCAAATGGTATTTCTAGTTCTAGATCCCTGAGGAATCGCCACACTGACTTCCACAAAGGTTGAACT

[1177] AGTTTACAGTCCCACCAACAGTGTAAAAGTGTTCCTATTTCTCCATATCCTCTCCAGCACCTGTTGTT

[1178] TCCTGACTTTTTAATGATTGCCATTCTAATTGGTGTGAGATGGTATCTCATTATGGTTTTGATTTGCAT

[1179] TTCTCTGATGGCCAGTGATGATGAGCATTTTTTCATGTGTCTTTTGGCTGCATAAATGTCTTCTTTTGA

[1180] GAAGTGTCTGTTCATGTCCTTTGCCCACTTTTTGATAGGGTTGTTTGTTTTTTTCTTGTAAATTTGTTT

[1181] GAGTTCTTTGTAGATTCTGGATATTAGCCCTTTGTCAGATGAGTAGGTTGCGAAAATTTTCTCCCATTT

[1182] TGTAGGTTGCCTGTTCACTCTGATGGTAGTTTCTTTTGCTGTGCAGAAGCTCTTTAGTTTAGTTAGAT

[1183] CCCATTTGTCCATTTTGGCTTTTGTTGCCATTGCTTTTGGTGTTTTAGACATGAAGTCCTTGCCCATG

[1184] CCTATGTCCTG AATG GTAATG CCTAG GTTTTCTTCTAG GGTTTTTATG GTTTTAG GTCTAACGTTTAAG

[1185] TCTTTAATCCATCTTGAATTAATTTTTGTATAAGGTGTAAGGAAGGGATCCAGTTTCAGCTTTCTACAT

[1186] ATGGCTAGCCAGTTTTCCCAGCACCGTTTATTAAGTAGGGAATCCTTTCCCCATTGCTTGTTTTTCTC

[1187] AGGTTTGTCAAAGATCAGATAGTTGTAGATATGTGGCGTTATTTCTGAGGGCTCTGTTCTGTTCCATT

[1188] GATCTATATCTCTGTTTTGGTACCAGTACCATGCTGTTTTGGTTACTGTAGCCTTGTAGTATAGTTTGC

[1189] AGTCAGGTAGTGTGATGCCTCCAGCTTTGTGCTTTTGGCTTAGGATTGCCTTGGTGATGCGGGCTCT TTTTTGGTTCCATATGAACTTTAAAGTAGTTTTTTCCAGTTCTGTGAAGAAAGTCATTGGTAGCTTGAT GGGGATGGCATTGAATCTGTAAATTACCTTGGGCAATATGGCCATTTTCATGATAACTGATTCTTCTA CCCATGAGCATGGAATGTTCTTCCATTTGTTTGTATCCTCTTTTATTTCATTGAGCAGTGGTTTGTAGT TCTCCTTGAAGAGGTCCTTCACATCCCTTGTAAGTTGGGTTCCTAAGTATTTTATTCTCTTTGAAGCAA TTGTGAATGGAAGTTCACTCATGATTTGGCTCTCTGTTTGTCTGTTATTGGTGTATAAGAATGCTTGT GGTTTTTGTACATTGATTTTGTATCCCAAGACTTTGCTGAAGTTGCTTATCAGCTTAAGGAGATTTTGG GCTGAGACAGTGGGGTTTTCTAGATATACAATCATGTCGTCTGCAAACAGGGACAATTTGACTTCCT CTTTTCCTAATTGAATACCCTTTATTTCCTTCTCCTGCCTGATTGCCCTGGCCAGAACTTCCAACACTA TGTTGAATAGGAGTGGTGAGAGAGGGCATCCCTGTCTTGTGCCAGTTTTCAAAGGGAATGCTTCCAG TTTTTGCCCATTCAGTATGATATTGGCTGTGGGTTTGTCATAGATAGCTCTTAATATTTTGAGATACGT CCCATCAATACCTAATTTATTGAGAGTTTTTAGCATGAAGGGTTGTTGAATTTTGTCAAAGGCCTTTTC TGCATCTATTGAGATAATCATGTGGTTTTTGTCTTTGGTTCTGTTTATATGCTGGATTACATTTATTGAT TTG CGTATGTTG AACC AGCCTTG CATCCCAGG G ATG AAG CCCACTTG ATC ATG GTG AATAAG CTTTT TGATGTGCTGCTGGATTCGGTTTGCCAGTACTTTATTGAGGATTTTTGCATCAATGTTCATCAAGGAT ATCG GTCTAAAATTCTCTTTTTTGGTTGTGTCTCTGCCTG G CTTTG GTATCAG G ATG ATTCTGG CCTC ATAAAATGAGTTAGGGAGGATTCCCTCTTTTTCTATTGATTGGAATAGTTTCAGAAGGAATGGTACCA GTTCCTCCTTGTATCTCTG GTAG AATTCAGCTTTG AATCCGTCTG GTCCTG G ACTCTTTTTG GTTG GT AAGCTATTGATTACTGCCACAATTTGAGATCCTGTTATTGGTCTATTCAGAGATTCAACTTCTTCCTGG TTTAGTCTTGGGAGAGTGTATGTGTCGAGGAATTTATCCATTTCTTCTAGATTTTCTAGTTTATTTGCA TAGAGGTGTTTGTAGTATTCTCTGATGGTAGTTTGTATTTCTGTGGGATTGGTGGTGATATCCCCTTT ATCATTTTTTTATTGCATCTATTTGATTCTTCTCTCTTTTCTTCTTTATTAGTCTTGCTAGTGGTCTATCA ATTTTGTTGATCCTTTCAAAAAACCAGCTCCTGGGCCAGCCGCCCCGTCCGGGAAGGAGGTGGGGG GGTCAGCCCCCCGCCCAGCCAGCTGCCTCGTCCGGGAGGTGAGGGGCGCCTCTGCCCGGCCGCC CCTACTGGGAAGTGAGGAGCCCCTCTGCCCAGCCAGCTGCCCCGTCCGGGAGGGAGGTGGGGGG GTCAGCCCCCTGCCCGGCCAGCCGCCCTGTCCAGGAGGGAGGTGGGGGGGGTCAGCCCCCCGCC CGGCCAGCCACCCCGTCCGGGAGGGAGGTTGGGGGGTCAGCCCCCCGCCCGGCCAGCCGCCTCG TCCGGGAGGTGAGGGGCGCCTCTCCCCGGCCGCCCCTACTGGGAAGTGAGGAGCCCCTCTGCCC GGCCACCACCCCGTCTGGGAGGTGTACCCAACAGCTCATTGAGAACGGGCCATGATGACAATGGC

[1190] GGTTTTGTGGAATAGAAGGAGGGGAAAAGCGGGGAAAAGATTGAGAAATCGGATGGTTGCCGTGTC TGTGTAGAAAGAGGTAGACATGGGAGACTTTTCATTTTGTTCTGTACTAAGAAAAATTCTTCTGCCTT GTGATCCTGTTGATCTGTGACCTTACCCCCAACCCTGTGCCCTCTGAAACATGTGCTGTGTCCACTC AGGGTTAAATGGATTAAGGGCGGTGCAAGATGTGCTTTGTTAAACAGATGCTTGAAGGCAGCATGCT CCTTAAGAGTCATCACCACTCCCTAATCTCAAGTACCCAGGAACACAAACACTGCGGAAGGCCGCAG GGTCCTCTGCCTAGGAAAACCAGAGACCTTTGTTCACTTGTTTATCTGCTGACCTTCCCTCCACTATT GTCCTATGACCCTGCCAAATACCCCTCTGCGAGAAACACCCAAGAATGATCAATTAAAAAAAAAAAAA AAAAAAAAACAGCTCCTGGATTCATTAATTTTTTGAAGGGTTTTTTTGTCTCTATTTCCTTCAGTTCTG CTCTGATTTCAGTTAATTCTTGCCTTCTGCTAGCTTTTGAATGTGTTTGCTCTTGCTTTTCTAGTTCTTT TAATTGTGATGTTAGGGTGGCAATTTTGGATCTTTCCTGCTTTCTCTTGTGGGCATTTAGTGCTATAA GTGTCCCTCTACACACTGCTTTGAATGTGTCCCAGAGATTCTGGTATGTTGTGTCTTTGTTCTCATTG GTTTCAAAG AACATCTTTATTTCTG CCTTCATTTCG TTATGTACCC AGTAGTCATTCAGG AG CAG CTTG

[1191] TTCAGTTTCCATGTAGTTGAGTGGTTTTGAGTGAGTTTCTTAATCCTGAGTTCTAGTTAGATTGCACTG

[1192] TGGTCTGAGACACAGTTTGTTATAATTTCTGTTCTTTTACATTTGCTGAGGAGAGCTTTACTTCCAAGT

[1193] ATGTGGTCAGTTTTGGAATAGGTGTGGTGTGGTGCTGAAAAAAATGTATATTCTGTTGATTTGGGGTG

[1194] GAGAGTTCTGTAGATGTCTATTAGGTCCCCTTGGTGCAGAGCTGAGTTCAATTCCTGGGTGTCCTTA

[1195] TTAACTTTCTGTCGCGTTGATCTGTCTAATGTTGACAGTGGGATGTTAAAGTCTCCCATTATTATTGTG

[1196] TGGGAGTCTAAGTCTCTTTGTAGGTCACTAAGGACTTGCTTTATGAATCTGGGTGCTCCTGTATTGG

[1197] GTGCATATATATTTAGGATAGTTAGCTCTTCTTGTTGAATTGGTCCCTTTACCATTATGTAATGGCCTT

[1198] CTTGGTCTCTTTTGATCTTTGTTGGTTTAAAGTCTGTTTTATCAGAGACTAGGATTGCAACCCCTGCCT

[1199] TTTTTTGTTTTCCACTTGCTTGGTAGATCTTCCTCCATCCTTTTATTTTGAGCCTATGTGTGTCTCTGC

[1200] ATGTGAGATGGGTTTCCTGTATGCAGCACACTGATGGGTCTTGACTCTTTATCCAGTTTGCCAGTCT

[1201] GTGTCTTTTAATTGGAGCATTCAGTCCATTTACGTTTAAAGTTAATATTGTTATGTGTGAATTTGATCC

[1202] TGTCATTATGATATTAGCTGGTTATTTTGCTCGTTAGTTGATGCAGTTTCTTCCTAGTCTCGATGGTCT

[1203] TTACATTTTGGCATGATTTTGCAGTGGCTGGTACCACTTGTTCCTTTCCATGTTTAGTGCTTCCTTCAG

[1204] GAGTTCTTTTAGGGCAGGCCTGGGGGTGGCAAAATCTCTCAGCATTTGCTTGTCTGTAAAGTATTTTA

[1205] TTTCTCCTTCACTTATGAAGCTTAGTTTGGCTGGATATGAAATTCTGGGTTGAAAATTGTTTTCTTTAA

[1206] GAATGTTGAATATTGGCCCCCACTCTCTTCTGGCTTGTAGAGTTTCTGCTGAGAGATCCGCTGTTAGT

[1207] CTGATGGGCTTCCCTTTGTGGGTAACCCGACCTTTCTGTCTGGCTGCCCTTAACATTTTTTCCTTCTT

[1208] TCAACTTTGGTGAATCTGACAGTTATGTGTCTTGGAGTTGCTCTTCTCAAGGAGTATCTTTGTGGCGT

[1209] TCTCTGTATTTCGTGAATCTGAACATTGGCCTGCCTTGCTAGATTGGGGAAGTTCTCCTGGATAATAT

[1210] CCTGCAGAGTGTTTTCCAACTTGGTTCCATTCTCCCCGTCACTTTCAGGTACACTAATCAGACGTAGA

[1211] TTTGGTCTTTTCACATAGTCCCATATTTCTTGGAGGCTTTGTTCGTTTCTTTTTATTCTTTTTTCTCTAA

[1212] ACTTCCCTTCTCGCTTCATTTCATTCATTTCATCTTCCATCACTGATACCCTTTCTTCCAGTTGATCGC

[1213] ATCGGCTCCTGAGGCTTCTGCATTCTTCACATAGTTCTCGAGCCTTGGCTTTCAGCCCCATCAGCTC

[1214] CTTTAAGCACTTCTCTACACTGGTTATTCTAGTTATACATTCGTCTAAATTTTTTATTATTTTCATTAAAA

[1215] AAAACTTTTGGGGTCCCTCCCTTAATCCTGCTTCTCTCTTCAGTTATTACCTCATTCCTCTTCTTCCTT

[1216] CGACAGTAAAACTTCTCAAAAGACTTGTTGGTATTCACTGTCCAGTTGCTCTCCTTCCTTTTTATCTTG

[1217] GACCCCACTCAAACCAGGCTTTTGCCCCTGCTGCTCCAGAAAACATCTTTTTTTTTTTTTTTTTTCTCT

[1218] CTCTCAAGGAAGAGTCTCACTCTGTCCCTCAGGCTGGAGTACAATGGCATGATCTCAGCTCACTACA

[1219] ACCTCTGTCTCCAGGGTTCAAGTGATTCTCCTGCCTTAGTCTCCCAAGTAGCTGGGATTACAGGTGC

[1220] ACACCACCACACCCAGCTAATTTTTGTATGTTTAGTAGAGACAGGGTTTCACTATGTTGGCCAGGCT

[1221] GGTCTGGAACTCCTGACCTCAAGTGGTCTGCCCATCTCGGCATCCCAAAGTGCTGGAATTACAGGC

[1222] ATGATCCACTGTGCCTAGCCAGGAAACAGCGTCTTAATATGATAGTTACTGGTGGCCTCCATGTTGC

[1223] TAGATCCAGCAGTAAAATTCTCAGTCCACAGTTTATTTGACCTGTCAGAAACATCTGATACAGTTGAT

[1224] CACACACTTCTTCATGAAACAGGTTCTTAATCCCTTGTTTAATTGTGTTCTTAGTTTCTTGCTGCTCAG

[1225] AATGTGGTCTGAGTAGCATCTGTACCACCTGGGAGCCTTTTAGAAATGCTAAGTTTTAGATACCACCC

[1226] CAGACCTGAATCAAAGACTGCATTTTAACAAGATCCCCAAATGATTCGTGTCCATATTAAAGTGTGAG

[1227] AAACACTGCTTTCAGGCATATTCTCCTGATTACCCTTCTACTCACTGTCTACTCCTCAGCTGGTTCCT

[1228] CCTCTCCTTCTTTGGTGTTTCGTGGTTGGACAAGTCATTTAAAATACCTGTAATCAGGGCCGGGTGT GGTGGCTCACGCCTCTAATCCCAGCAGTTTGGGAGGCCAAGGCAGATGGATCACTTGAGGTCGGGA GTTCAAGACCAGCTTGACCAAAATGGTGAAACCCCATCTCTACTAAAAATACAAAATTAGCTGGACGT GGTGGTACTTGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCGGGAGAATCACTTGAACCCGGGA GGCAGAGGTTGCAGTGAGCCAAAATCGTGCCATTGCACTCCAGCCTGGGTGACAAGGGCAAAACTC CATCTTAAATAAATAAATAACCTATAATCAGAACCAGCAATACAAAGTATTATCAAGGATAAAGAACAA CTGGAACTCTCATACATTGCTGGTAAAGATTTTAAATGATACAGCCATTTTAGGGATCAGGTTGGCAG TTTCTTTTAAAGTTAAATTTACCATTTGTGCAATTCTAATCCTACCTAATTACCCAAAATAAATGAAACC ATCAGTCAACAACAAAG ACTTGTATATG AATAC AG CATCTTCTTCATATTTG CCACAAACTAG G AAC AA CACAGTGTCCAATAAGTAAATAGATAAGTTGTGATATACCCATACCCCGTAACACTGCATGCAGCCA

[1229] GTGCGTGAATCTCACAATTGTTTTGCTGCGCAAAAGAAGCCAGGTGATTCTGTTTATATGAAATTTGA GAAAAGGCAAAATTAATCTGTAGTGACAGAAGTCATTATCAATGGTTTCCCAAGCCTAAAGGGGGTG TTACTAATCGCAAAAATGTATGAAGAAACTTTCTGGGGTGACGGATATTCTTTATATTGATTGTGACTG GTCATTACACAAGTGTATGTGTGTGTTGAAACTTTTAAAACTGTCCATGTAAAATGGGTGCATCTTGT GTGTAAACTGTACCTCAGTAAATTTCAGTTTTTAAAAGTGAAAAATACCTGATGGCTTACACCTATAAT TCTAGCACTTCGGGAGGCCGAGGTGGGAGGATGGCTTGAGCCCAGGAGTTCAAGACCAGCCTGGG

[1230] CAACATAGTGAGACCCATCTATACAAAGCAGTTTTTTAATTATCCAGGCATGGTGGCGCCCACCTGTA GTCCCAGCTACACAAGATGCTGAGTTGGGTGGATCTCTTGAGCCCAGGAGGTTGAGGCTGCAGTGA GCTGTGATCATGCCACTGTACTCCAGCCTGGGCAAGAGAGCAACACCCTGTCTCCAAAAAAAAAAGT GAAGGAAACTAAAAAATCAAGGCAAAAATAGAATTTAGGCCACTATGGAGCATAACTTTAAAATATGT GAACTTTACCTATTCGATATTTTAATTATTTTTAAAGTGATAAATGATTACTGACTACAGAGAAGTAACA GAATGCCATTCTCGTTAATCTTACTTTCCAGGGTTGTAATAAGGGAGCAGAGGGCATCAAAGTATAA GGAAGGCTGTAATTTGGCACTGTCACCACTATCATACCTACCAGTCCAGGTGGTCACCCAAGGAGA GACTCATCTTGCTGCCTAAAGTCTGATGAACCTTTGTAAAATTGTGCAGTATTAGGTGAAAGAGGGCT GACATGCAAATGTCTAAGTAGGTCAGTTCTGTGTTTTACCAAGAGTTTAAAATACTTGAAAATGGCAG

[1231] CAGACTTAAGTGAGAGATGCTAGTGGCTTTTACAAATAAGCTAAGTTGATAAATTAGCCAAATGGCAT AGCAATATTATCAATAGGCATTTTAATGATAATCTCTCATTGTTTTCTTAAGGATAAGATCAAGTGATG

[1232] TAACATGAATGACAGGATTTAACTGGGTTCATACTGGATGAATGATCATACCTGAAGACAGCAAACTA TAATGAGATTCCTATCCTCAGTCCTCTCTTGAATATAATTACGTATTTAGAAGTAACTTATGTGAGGAA TTATTAGCATGCCGATCTTTAAAAATCTCCTTTTTTCAGCTCTCACGTAAGACTCTTGAAACAAGAAAA TAAAAATAACCTATGTTTTATTAAAGAAAAATGAAGCAGGCAAGAAAAAACCGACTTTTTTAGTGAAAG CTAAAGTTTTAATCTGAAATTATAGACCATGTCTACAAAATTTAAAATCCTAAGGCTGGGCGTGGTGG CTCACG CCTGTAATCCC AG CACTTTGG AAG GCTG AGG CAG GCAG ATCACG AG GTCAAG AG ACTG AG CCCATCCTAGCCAACATGGTGAAACCCCATCTCTACTAAAAACACAAAAATTAGCTGGGCATGGTGG CGCGCGCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCTAGGAGGTG GAGGTTGCAGTGAGCCGATATCGCACCACCGCACTCCAGGCTGGTGACAGAGTGAGACTCTGTCTC

[1233] AAAAAAAAAATCCTAGTCAAGTCCAAAAAAAGAGAAATATACAAGTATAAGATGGGGAAAATGTTTTAT AGGAGCAATTCAAGAATAATTATTCTAGGATTGTAATTGAATATAATCCTTTTTGTGCCCTTTTTTAAAA ATTCTATTTATTGTCATAAATTTTGACCCAGCAGCAGGAAGCATGTAATTAAATATAATTTTAATTGGA CTCAGTAGCATGACTTTGGCTGCCATAACAATCACAATAATGTCTGATTTAATGTTGTATGCCCACCA TGTGGGAGATGAAGATGAGGATCTCACCATAGTTTGTGTTGGTTAGATCCGATCTGAAGTATTGCTTT TAATTTGGGGCACCACATTATGCTCTGTAAGAATGTGGAAAAGCTGAATCTTGGATAAGAGCTTGAA GTAGTGTGAGAAGAAATTTTACCAGATGATTTTGTAGCTCTAAGATTAAATGGTTCTATAGGTGGACA CTTTTTCTTCAAGGAATGAGACTGTTAAGAGAAACCTATCAAGAGAATGTGTTGTTCCTTTGGTTGAT AGCATATTTGTTCTTTCCTAGTACTTCTGTAAAACTGTAATGCTCTCCTTAACATCTTACCAAGGAAAG AGGGAGGTCCAATCTAATTATCCTAATTAATGGATTGACTTCTGTGTCATATATGGCAAAGTAAAGTT GATATATTCTTGTTCCCTTCCCTACTCCCAAACAGTTATGTGAGTTATTTGTTTTCTGTTATTTTTGTTT GGGTTTTTTTTTTGGCATTTTCCATTGTAACTGGGTGGTGCTTAGGAAATTACGTTTTAGTGTCCCCC TATATAGAATTATTTAGGGTAGTGATTACTGTGAAACATTATCTTATGTAGGGATTCGGTTGTGTCTCA TCCCATTTCTCTAG CTG GG GG ATTAG ACCCCCTTTTCCTTCCAG CCTTTC ATTCTACAG ACCTG G ACT TCTACTCTTTG CTG CTTTTGTTACAG AAG G ATTACAG AAAG AG AATTATTCAATG AG ATAAAAATTAAC AAAGCAGTTTGTAAGTAATAAAGGATTACACAGGTATAAAGTGTTGTTTCAGGTTGTATTTTTATGCAA CTCGGCCTATAACAAATTTATGCTATATAACTTCTATGCTGGGTATATCACTGGTTCCCCAATTACATT TATATCTTGTTAATTATCTAGTGCTTTCCTGGTCAGAAAATTTCTCTCCCCACTCTCCCCAGTTACATT TCTGTCTACTCTATTCTTGCTATATTCCTCTGCATCAAATTTGTTGAAAGGATTAACACCATCCCATGG AGAACACCTTTATCTTCCCCTCTTTTATCTTCAGCATGCCTCTGTATTTTGATATGGTTGAAGCCCATT TGTTTTTGTTTTTAAGTCTTGCAGGAAAAAGAACCTCCTTTCAAAGACCAACACCTTGGCTGTATACTA GATCCCAGGTCTCTCTGAGTGCAGGACCTAGCTCCACCAACCAACACCATCATCATTTATCCCCCTT TCTTTCTAATGGAGACAAGATCTCACCATCTTAAAGCTTTGATTGGGGCCCATTTATTTCCACCAGTTT TTAACTTTGTATGTCACTGCAGAACTTTGTAAGCAGTGAGACCTATAACCGAAATAACATTTTCTTTCA GTGAAAGAGTGACAATATGATGTAGAACACTGAGCCTAAAGTCATGACAAGATAATTTTCAATTGTAG TAAATGCTATGAAGAACATAAACTGTGATATGAATAGTAATTGGAGAAGGGATTACTTTAGATAAATA GTAATTTGAAATGAAAATTTTATCTAGAAAATACTTTAAAATTTTTGATATTGGGAAGAATGAGGACGT TTAAATGAAGATGAGACAGCATGAATAATCTTGGTTATTTGCAAATCTTCCACTTTTAACAGTGTTTAT TGCATGATTTTGATTATACCATTTGGATTTTAAATTCTCATTTTAAGGTAAAACTGTCTAATGATCATTG TCAGATTTCAGAAGTGTCATATAGCTATTCTCTCCGGTATTCAATTAAGAAAAATAACCTTGACTAGCA CATTATATGCATCTTATTGTAGTTGATTCAGTAGACATGTATTGAATACTTACCACACATACCAAGCAC TGTTCTCGGCACTGGGTATACAAAGAAATAAACAAGACACAGCCCTTTTGAGACAGGAGGATCTCTT GAGCCCAGGAGGTGGAGGTTGCAGTGAGCCAAGGTCGTGCCACTACACTCCAGCCTGGGTGATAG AGTAAGACTTTGTCTCCCCAAAAACAACAACAACAATGCTGCCTTTTACTTCAATGAATGTAGCTAAA GCAGTTTTTAGGGGTAACATAGATGATTTTAAAGTTATCGTTGACTTTAAAATAGACCTACTATGGCCA

[1234] TTTTAGAGAAAGTTTTCTCCTCACTAGTTTTAAGAAAATATTTTAAGAATATATGACAACTACCTTTAAA AATAGTTTTAATTACCAAACTGCATGTTCTAGTAGTTTACATTCCAAATAGAAGTGAACATAGGCACGT TGAAAAAACACATGAATCAAGCCATTATTATGATAATTACTACATAAGTTGAGCAGTGAAAGAGCACT TTCAGTTCGGTTAGTCATGGGAAAGCTTCACTCAGGAGTTAGAATTTGTATTCAGTTTTAAAGGATGG ATATGAATAGGTGGAAAATAGAACGAAAGCTAACTTGGAGGGTTGGGTGTAGGAGGGGAGCATTGA ACACAGTGGTGGGATTAAATATCAAGGTATATTTAAGGGACATGGATAAATAGGCTTGACTGGAGTG AAAGGTTTGTATTGGTAACTAGTAAAAGATAAAGCAAAGTCTTTTAATAGAAAACAAGATTTTGACTGT ACCATTATAGTGATATGTTCCTATAATCTTAAATTCATTTACAGTCTATTTTAATATTCTGTGAAGGGTT TATTACAATGTACTATTTTCAGTTGTATCATGATTCTAAATAAGTCTTTACACCCCCAAGTATGTTCTGT AGATTTCGAGGCCAGAGTCCTTTAGCCCTACTCAGGTTAAAATGATGTTTTGTTTTTCAGTTACTTACA CGCCAAGTCAATCATCCACAGAGACCTCAAGAGTAATAGTATCCTTCCTGAAATTTGTCTGCGAAGTT TGAAAACATCCTGACTTTTTCTTCTGCATTTTGTCTTCACATTATGTAAAAACAGTTTTCATGCTAAGTT CGATATACTGTAAAGAGAATTAATAAAGGATTGTGCATGCATGTATAGGAGAGCAGGATACCACAGC CTGCTTTTGGTTTCTCGACAACTGAACATTACAAGAAAATCTATCAGAAGTCTTTACAATAGTAGGAG TTTTTGATTGCTTGCTTACATTTTATCAGCACTATAAAACTGATAGTTTTGTAGCTATCTATTAGTCCCT TTCAGACCTCTGACCTTGCTCAGTGGTAGTTGAGATATAACTGAAGACTCTAAATTATATAACAATGA GGTGAGAAAAACATAATATTTCTCTTCCCTAAGTGCAGACTAAGATACTATCTGCAGCATCTTCATTC CAATGAAGAGCCTTTACTGCTCGCCCAGGAGTGCCAAGAGAATATCTGGGCCTACATTGCTAAAATC TAATGGGAAAGTTTTAGGTTCTCCTATAAACTTAGGAAAGCATCTCACCTCATCCTAACACATTTCAA GCCCCAAAAATCTTAAAAGCAGGTTATATAGGCTAAATAGAACTAATCATTGTTTTAGACATACTTATT GACTCTAAGAGGAAAGATGAAGTACTATGTTTTAAAGAATATTATATTACAGAATTATAGAAATTAGAT

[1235] CTCTTACCTAAACTCTTCATAATGCTTGCTCTGATAGGAAAATGAGATCTACTGTTTTCCTTTACTTAC TACACCTCAGATATATTTCTTCATGAAGACCTCACAGTAAAAATAGGTGATTTTGGTCTAGCTACAGT GAAATCTCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGTCTGGATCCATTTTGTGGATGGTAAGA ATTGAGGCTATTTTTCCACTGATTAAATTTTTGGCCCTGAGATGCTGCTGAGTTACTAGAAAGTCATT GAAGGTCTCAACTATAGTATTTTCATAGTTCCCAGTATTCACAAAAATCAGTGTTCTTATTTTTTATGTA AATAGATTTTTTAACTTTTTTCTTTACCCTTAAAACGAATATTTTGAAACCAGTTTCAGTGTATTTCAAA CAAAAATATATGTCTTATAAACAGTGTTTCATATTTTATTCTTAAATAAATATGAACCCTTAAAACGAAT ATTTTGAAACCAGTTTCAGTGTATTTCAAACAAAAATATATGTCTTATAAACAGTGTTTCATATTTTATT CTAAATTGTTTAAAGTATTTTGTGTTCAAAATGTTCTGTGTACCCTGTTGAAAAAAAAAACAGGTATGC AATTTAAGGCAGGTGTGATCCACAGCCATTATTATGGTTTTGCTAAGAGAACTACTCCTTTTAACAGA GAAGCTGTTTCGCAATCTTATTTAAGCCTAAATTGGAAAGTTACTTCCTTTAGACTAGAAAGTATCTCA TAATTATGGGGCAGCTGGAAGAGGAAAGACAAAAAAAAATGAGAGGTAGATTAACAGCCTTGTGCTG TCTTGCATAGCTCTTTCTTTCTTCTTGTTTTTTGCTTTGTGGAAAAGAAGAAAGAGAAGTTCTAAAAGA

[1236] AGGGAACAAAAACTTGTGTGCATTGCAGCAAGCTGTGGAAAGCTCAGTCATATGAATCATTCCCTAA AACAG CATTCTTAAAAGG GTCCCTCAC ACCGTTTTAG AG G GTCC AC AAG ATCTTCCCTTTGTG AG AC AAGATTTTCTTTATATCCTTCAACCAAAACAACACATTGCAACAGACTGAGTGCAAAAGCAAATATGA GAATCCAGCTGGCTGCTGTTAAGCCAGACATTGAGGAGAATCACAGGCCACTCATGGTGGCTGGAG TCCATAGTTCCAGCTACCTGGGAGGCTAGGGCAGGAGGATCACTTGATCCCAGGAGTTGACTGGCC TGCTCAACATAGTGAGACCCCATCTCTAAACCATAAAAGGAGGATAATTGTAGTACTATTCTTCTTAC TAAACTTTTTTTTGATAATAGTTATTTTTCATTAAAAATGAATGATCTGTGTTAACATCTACTTGTTATTA TTTTAGTAGTTAAATGAATTACTAGTTTAATTTCTCCATTAAATTTTAATGGTAAACATCCACAGATATA ATCTACCTAAACAAAAGTTCTTTATCATCCTCAATAATTTTTAAGAGTGAAAAAGAGTCCTGAGACCAA AAAGTTTGAAAAACACAGCTCTAAGCTGAATACAGCCTTTCCAAAAGTCTTAGTGCAATTCTAAGCTT TAAATAACTTAATCTGCACTAAGACTTTCGGGCACCCTGCTGGAAACAGAAAAGTTGTAAGGGCTTTC AAAGCCACAAACTTTATGTAGCAGTCTCCAGAAAGGGAAGTCCAAGATAGGACTCCCAAGTTTGTCA AAATAAACCTAGAGTTAAATTGAGCTGTGATTTCTTATGACAGTAAGTGGAATTAGGGCAGGTGGCAA GGTGGAAGAGGGGACATTGGACTTAGAAGATCTGTATTCTGGTACCCTATTTGGCCATTAACCTGCA AGTTTCTTAACCTCCTCTAAGTCTACATCTGAAATGTTGAGTTGGACTAGTAGATTTCCAATGCCCCTT TTTTCTAAGATTCGGTGACTGGAGTTAGCTAGATTTTTTCCATTATTTAACATATGTTTAACTTTTAATT AATAATTATAAGTGATAGAAAAATTAATAACTATAATCTGATGTCAGGCACCTTTATTAAGGCATACAC ACCTTGTGAAAAAGATGGCAGTGTATCCTAAAAAGATGAGGGAAAACAGATTTTAAGTGCTGAAATTG CAAAACCTAAAATTATAAACAATTGTCACGTGCTTTTAAAGTATGTTAATTTTTGACTATGTGGGAGAG TTAGGCTCAATCAAGTCTCCAGTTTTGTCCTTACTTTTTCAAAAACCTTAGTTTATACAGTTTGTAGATT ATTATACATAAAGTTTTATATTTTCTTACAATTAATTTTTTGTTGATACCTGTGTAAATGGGTTTCTCCTT TATTCTTTCATGCTGAGTTTTAAGACGAGAGAATAATAGCCAACAGTACCCTTTATTGTTAAACCAATC CTGGGTTGATACTGCCCTCAGAAACAAATATGGAACATCCGTATCATAGGAGAGAAGAGTTTGGTCA TAACTAAGGCTGTGTGGTCCTTTGAATTATATACAATGTTCTTCTCAACTTTGTTTTATTTGTATCTTAG GAGAGAAAGAAACCTTTGTGAGAGTTTTTACAAATTAAATCACTAAATTGAAGATTCGTCATGCATTTC TTAAAATAGGTGACATGCAACTTTTCATCAAACTGTCTACCAACAACAGTGTGAGATAAAACTAAATTA AAAAAAAAAAGTTCATCTG ATTTCTACTCC ATCTCTCAC AAAAATTG GTCAG G CTTTG AACATTATACC TTTGCCATACCAGCCTCTCAGTATTCTGGCTTGCTTATTACATCACAGTTATATGTGGTTTATTTTGTA CTGTATTACTAAAAGCAACTATGAACAAAATGTATGACAAAGCGAAGTAGATACAACCTTCTCCTTCA CTTCCATCCTCTCACGCTCTTCAGGACATCCCACAGATCTTCCATCAGTGGTTCTCAACTTTGGTTGG ACACTAGAATCATCTGTGGAGCTTTAAAGACTAATTAATGTTTGGGTCCCACCCCCAGACTCTGTTAC GTTGTGTGATTGGACTGGAGTGTAGTCTGGACGTTGAGGGGTTTAAGGCTCCGCGGGTCATTCTCA TTTACAGCTGTTGCTCAGTGCCATTATTGCCTCTCCTTGTGAGATGCCTGCCTTACCCAGAGCAATAA CCAGGAATCTTGTCCCAGGTCTTTCAGTCATTTTTGCAGAGTTAGTACCACTTTTGCTGTCAAATTGA CATTGTCACAAACTTTTCATTAATATACTGCCATTTCGATTCCTTCCAAATGAAACAATACAGAAGACG CAAGGTGAAAGAATAACTCTTTTAAGCTAATAATTAACCAACTGTTTATTGTATTTCATGTAAATAAGA AACCTAATTGTGCAATACAATGACTGAAATGTGTAAAAATGTAGCAAATATGATTGTTTCATTGCCCAA GAAGCAGCAGCCAGAAGATTCTTTATACCATCTTTTACTAAATCTACCTGCTGTCTTGCTTTTGTTAAT AAAGCATCCATGGCATGTTTATACCATATGCTTATTCCATAGTTTGAAAGGGGATTTGAGTTTATCAGT CCTGAAATTCTACCATTATTTTCTAAGGTGTCCTCAGATGAGAAAAGTTGTTTGTACCAATGGGAAAA

[1237] CTTAAATTGTAAGACAGTTACTACAGTAGTTGTGCTGCTCCTAAGCATCTTATAACCACAAGTCTAGT ATTTCTTTGCTGAATCAGGAATGGGAAGTGGGAACTGATTCTAATAGGGTAAGTCATGGGAAGAATT CATCTGGCAATGATGGTATTTTCTGCAGAAAGATTGCCTAAATAATTACTAAATTATAAAATCTTAGTA ATACAATACAAAATCTCTGCTAATACTGTCTCTTTCTGAGTATGTAGAGGTTTTTTTCTTCAGCTTAAT CAGTTTTATTTCTTTGACTATTAAGAGAATTGATTACATATTAGACAGGTGTTTTAATGGTAAAAGCATT GCTCTAGGAATTATAGTAGGTTGTTTTTCAGTCTTTATTCAATTGAAGTGAAGAATATTTTTCTTTGTAT GTTCTAACAGGCACCAGAAGTCATCAGAATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATGTAT ATGCATTTGGAATTGTTCTGTATGAATTGATGACTGGACAGTTACCTTATTCAAACATCAACAACAGG GACCAGGTAAATATTTACCACGTCTTGGTGTTTATTTTACCGTCTATATACAAGGCTCCAGTTGTAGA AAATAAGTGTTAACTCCTGGGTAAGCGTGAAGGATAGATTTCTTGATTTTTTGTTACCAGTTTTAGAAA TCGTTTGTATACTTTTGGCAGTAATAGCAACACGTTAAGTCCTTTCCTCAGAATATCAGTCATGAATGT TACAATGGAATAAAATTCCTGATTTTCTGACTAGAAACTACAGTTACAAGAATGGATATTTCTTGACCA TCGCACAATTAGAAGAATGAGCTCTGCTACTATAGCATCTGGGCATTATACTTTTCACTGTATCACAG ATTGTGCTGTCAGAACAGGTACTCAGCTATGAGATCTTTATATTAAATTCTTTTAAAATTACTAAGGTT TCTTG AAATCTTTAATTTTTAAAACTAG GTAAATG G AAG AAATCATG CTTTG ATTTTTCTATAATG AG AA TGCTAGTAGGAGGGTAATTTTTTACTTCTTTTCCTTCCTAAGCAACTATTCCCTGTCCCTTACCTTCCA AAAGGTACTAACATAGCCTCATGGAGCTCTTAGCCTTTTCTATCTCTGCCTCAGTAGGCTCGCTTAGA CTTTTAAAATTGGCCAAGAAAAGTGAATTATCTTTACTAAAATTACCTTGGATAACTACATTTTAAAAGA TTTGTGATTGTGTGTGTAGAGAGATTACAACAGTTACACTGTTAATATATTAGAAAACACTAGTTGACC ACATAAACTCTGATTAAAGAATATTTCGACTTTATGCTGTGATTTGCCTCAGAATCACCTGGAAATTTT GCTTAAAAATGGAGAAACTGGAGCAGATTGTAATTAAATGGGGAGGGTCCAATCACCTGCATTTTTTT CTGTTTCCCAGGTGATTCTAATACAGACCAAAGTTGAGAATCACCAATCTAAAGATTTTTTTTAAAAAC AGTGCAGGCTTTTTAGGTATTTCATAACTTCCCAACCTAATGAAATGGTAGTTTTTGTATATAAATGTT ACTGCTTCATTTAAGTGATTTGTCTGTTTTGTCAAGAGCTCAGCTCTATCTTTTTGGTGCTAGCTCTGA GTAGCTTTCTCACTTCACCTATTGTGATATCGGAGAAATAATCTCTTAAGTTACCATGTACTTTGTGTG TGTACTTACTGAATCACCATATGCCCCTTACACAACAGTGGTCTTGACTGTGTTTGATGGTTTTTAAAA ATGGCTACATTTCTACCCAGTTCATTATAAAACTAAATTTTAGTTGGTGTTGGCCTTTCTAACTACTTC ATAGCTTTAGAATGTTGAGTCTTAGCTTTGAGTGTGTAACAACATGACTTTGGATCTGATGTTTTAAGC CTGCAGGAAACTTAGATTCAGGATGGACTGAAATTTCAGCTAAAGAACATAATTGAAACATTGTACTT ACTGTACTTGTGATAGATCTAGATCACTGAAATGATTGATTTGACAATGGCAGTTGGGGTAGCAAAAT GGTCTCTAATTTACAAGCTTCATGTCCTCTGTCTTTTACAGTCTTATTTATTCAATCATACAGCATAAC AGCCTGTACCATGTTCACTTTTCCTGTATATAATATTTTTCTGGAGGAATTATGGATTTTTAGTTTAGTT TCAGTTGATTTATCATATAGACTACAAATTAATAAAAATTTATGAACCTAAGATCTGGATGAAATTCATT TGTCAGTGAATACGTTTATCTTAGTACAATAATAAAATTATAATATAGAAACAAGTATTATCTCCAAAAT ACAGATAAAAGCATCCCAGAGTTCTTCTCTCATCCACTTCTTGGCATTTTAGGTGCTTTGTCCTCCAT GGGAGTATAATAAATGATGTGGCAAGGGCTTACTCTCCATGAGAGGAATGTGTGACCAACAGAAGG GTAAGGCCTTTACTAGTTAATTCTTTCTAATAGTATAGTTAGAACCTTCTGGAATTTGCTAGTCTGAAA CCAAGTTAAGTATTTAATGGAGAAGAAGGAGGTAAAAGAATGATGTCCTCTTACAACTACCCCCATTC TGCTTCATTACCCCCTAGTCTACTTACGTCAAATAGTACTTTCTATGAAACTCCACATTTTGAAGGGTT AACTCTGGCCATCCTCAGTGAAGCTGCCCCAGGTATTGCTCCATTCATCCTTTGATTTTTCTTTTGCT ATCTATAATACTTGGATCTCCATAGCTCTCAGATTAGACTTCTGTTTAAGAATCCAGGAATATTCTTTA CTATGCAATGTGAATACCATTCCCCTAGACTCTCATACCCATAGTCTGAGGTGGCAGATTTTGCCTGT AAATTCAGAGCACAGCTGGTAAAGCAGTGTGATGTAATGGCAGGCCTTGGACTCAGGTAGGTAGAC TAGGTCTACCTACCTCTCTGGGTATCTTTTTTTTTTCTTTTTTCTTTTTTTTTTTTTCCAAGACGGAGTC TTGCTGTGTCGCCCAGGCTGGAATGCAGTGGCCTGATCTCAGCTCACTGCAACCTCTGCCTCCCAT GTTAGCGATTCTTCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCACGCAGCACTACACCCAG CTAATTTTTTTGTATTTTTGGTAGAGACAGGGGTTTCACCATGTTGGTCAGGCTGGGCTCAAACTCCT AACCTGATGATCTGCCCGCCTCAGCCTGCCAAAGTGCTGGGATTACAGGCGTGAACCACTGCACCT GGCCTTTTTTCTTTTTTCAATTACCTGCAAAATAAGGGAATTCGGCTAAGAATTTCTTCCAGCTTCAAA AATCAGATTCTTTTCTAAAATAGTTCTCTTAGCTCTTTGCAAAGTAGTGTGCCTTTTTACCTTTATTCAC CCTAG CACTAAAGTCTG G G AAATCACTTTGTCATCCCCCCACTCTCTTTATC ATTCTAAC ATTTTTCTC TCTAATCACCCTGTTCTTCCCTCCTTCAGTGCATTTTCTCTTGTAAATTGGGATTAATAATGTGCTCAC TTAAGTATATTGACTATACCTTTATGGCTTTCGTTCCTTGGAGTAGAAGTGCCGTGTCTTCTTTGAAGA ATAGATAGCATATATCTGTTATTTCAAGTGTATTATTCCAGTTATAATTGCTGCATAACAAACCACCCA GAATGTAGTAGCTTAAAATATGAATCTGTAGGTTGGGCTTTTCTCTGTGAGGAAGATTCTTACCTGTT TCACACCGTATTGACTAGAGTAGATTTACGGGGTGTTAAAAGGATCTACTCAGAAGTGGCTCATTCAT GTACCTGG CAAGTTGGTG CTAG CTAG AAG CTAG AAG CTCAGTTATTCTCCACATG AG CTTTTCCTTGT GGACCTCTTCGCAGGTCTTCAAGGACCTCTTCATTGGTCTTTCTCACAGCGTGGTTGCTAGGTTCTA AGCACAAGATCTGAAGAAACAGGAAGTAAGTACTAGTCTCTTATCAGTAGGCAAATTATTTTAATAGA AAATGTTTTCAATACCAACTATATGCAAAGCACTATGGAATATAGAAGGATTCAAAATGAATAAAACAA AACCCAGGCTCTGCTCTCAATGGCATGTGCAGTTCTGTTGAGGCCGTGCTGGGGGTGATACTGAAA ATGAGCAGACATGAGCTCCAGTAATACCATGGAGTGAATTGACAGGGTCGAGACACCAGGAGTACT GAGTGTGTATTGAAAGTATGAAAAATCAGTCCCAGAATTTGAAGCTGGGGTATTGGTTTCGTTGTGTA TGTGCCACATGAATCTTCTGTCCATGAATAACATCCAGGAAAAACTTCCCTTTTTTCTTCTTTCTGTTT CTTCATCAGTC AG CCTCTG CACCCC ACCCCAG CAG ATACTG AAAGTTTCCTG CTTTCTG CTCTGCAC TAACTAAATTCTGTGGGATGTATAAAAACATGAGAGTTGTCTTTGATTTTTTTTCTCACATTCCTCCTG AAAGACTCTTGAAAAACTATGTATCTCCTTGTATATTTTTTAAGTTGGCATCTAAAAGTTTTTATCTTAA GTTTAAATAATTGCAAAGAATGTAATTTCCAGTATATTCTATTAACATTTTAAAATAAGACTACTATATT AGATACATATATATCCCTCTTTTTGAAATATATACATCAAAATCTAAAAACCATACCGATTTTATGCCTA TTAAAAAATACTGAAGCTCTTCATTAATTTCTGGAAGTTTTACATGGTTCCTTTTTTCTCTTCAAACTAT TTGTATTGTTTCTGTCACAGAACTTCATCCTAATGTAACATATTTGTATGTTTTAAAGCCTTTTATTGAT TACCTAAGTTACATCTCTGCAATAAAAGTATGTATATAAATTTAAATTTAGAATTTTACAAAATTGTGAC TTCAAGCTCTGATTATTAATTTTTTAATTCTGAATTATGTTTTTGTTGCAAGTAATATATAACTGATGAA AGTAGCATATAAGTTTTGATATATGGAAACATAGAATGTAAAATTATATTGGAAATATGTATCTTAATG AATGACATGGGGCTTTTCTTTTCCCTTCAATTAATGTATGTATCTGTGGATAAATACAACTTTTTTGTTA GGACACTAGATACTAAGACTTAGTATTGATTCTTTCCATATTTCATTTTTAAAGAGGTAAATACTGAGA AATTTTATCTAAATTATAAGAAGATGACAAAGGCAGGAGTTTTGTTATAATCACATGCAGAGTTTAGTA GTCCCCAAGACCAGCTTCAGGTTTGTTAAAAGGACTTGCTGAAAACTCACTGAAAGCTGCTCAAGAC TCACTGACAACTGTTACATTCACAGTTACAGTTTATTACAATGAAAGAATACAGATCAAAATTAACAAG GGAAGAGACTCATAGGACAGAATTCAGAAGCGTTCTTGTTGGAGCTTCCTGTCACCCTCTCCCAATG GAGTTGTGGACAGAGCTTCCAGTAGCAATGTGTGACAACACACATGGATTATTGCCAACCAGGGAAG CTCACCTGAGCCTTGGAGTCTAGAGTTTTTATTGGGGTTCAGTCATATGATTAACCACCTGCGGGGC TGACCTTAGTTTCCAGCTCCTGCAGAGGTCAAGCTGATGCCACATGACCCAGAGCCCTCTATAAATC ACATTGTTAGCACAGTCTGTCTGGCATGGCCCATGGCCCCCAGATAAACAGACACTCTGATCAGGCA GGACATTTCAAGGACTTAGTGATTACCTCCCAGGAGCCAAGAGCAAAGGCTAGCTCTCTCTTTGGGC AAGGTTAATTCTTTACCACATACTATATATCACTCAATCATCTGAGCTCATTCCTATAATGTACCAAAA

[1238] TTTACATAGTAACTTGTCATTAAAAATGTTTTAAAAGCTCAGCTGACATTTCAATTAATATTTTTGAAAG TAAAGAATTGGAAACCAACAGACTCGTTACCCATTCGTTGGAGCCCAGTTTGACACCAGTATTTAGAA ATGTCTCTTTGTTGCCCCAGAGGTTTTTACACCCTGGGACAATGTATACTATAGTTAGGTTACATATG GGTAAAAGGTGTGCCTTTTTTTTTTTAATTAAAGTTTTAGGGTACATGTACACAATGTGCAGGTTAGTT ACATATGTATACATGTGCCATGCTGGTGTGCTGCACCCATTAACTCATCATTTAGCATTAGGTATATC TCCTAATGCTATCCCTCCCCACTCCACCCACCCCACAACAGTCCCCAGAGTGTGATGTTCCCCTTCC TGTGTCCACGTGTTCTCATTGTTCAATTCCCACCTATGAGTGAGAATATGCGGTGTTTGGTTTTTTGT TCTTGAGATAGTTTACCAAGAATGATGATTTCCAGTTTCATCCATGTCCCTACAAAGGACATGAACTC ATCATTTTTTATGGCTGCATAGTATTCCATGGTGTATATGTGCCACATTTTCTTAATCCAGTCTATCAT TGATGGACATTTGGGTTGGTTCCAAGTCTTTGCTATTGTGAATAGTGCCGCTATAAACATACGTGTGC ATGTGTCTTTATAGCAGCATGATTTATAGTCCTTTGGGTATATACCCAGTAATGGGATGGCTGGGTCA AATGGTATTTCTAGTTCTAGATCCCTGAGGAATCGCCACACTGACTTCCACAAAGGTTGAACTAGTTT ACAGTCCCACCAACAGTGTAAAAGTGTTCCTATTTCTCCACATCCTCTCCAGCACCTGTTGTTTCCTG ACTTTTTAATGATTGTGATTCTAACTGGTGTGAGATGATATGTCGTTATGGTTTTGATTTGCATTTCTC TGATGGCCAGTGATGGTGAGCATTTTTTCATGTGTTTTTTGGCTGCATAAATGTCTTCTTTTGAGAAG TGTCTGTTCATGTCCTTTGCCCACTTTTTGATGGGGTTGTTTGTTTTTTTCTTGTAAATTTGTTTGAGTT CATTGTAG ATTCTG G ATATTAG CCCTTTGTCAG ATG AGTAG GTTG CAAAAATTTTCTCCCATTTTGTAG GTTGCCTGTTCACTCTGATGGTAGTTTCTTTTGCTATGCAGAAGCTCTTTAGTTTAGTTAGATCCCATT TGTCAATTTTGGCTTTTGTTGCCATTGCTTTTGGTGTTTTAGACATGAAGTCCTAAAGGTGTGCCTTTT GTAAAGTGGTAGAAGGGCAGTTATAACAGGGAAAATGGGAAAGCAAGATAAGTGTTACACTTCCACT TGAGTGGTTCTCTGGCAAATCAGTTTTTTCAAAGGGGATACCAGTAAGTTGATAGTTGTAGAAATTAA TTCCCTTAAAACCACCATGTTGGCTGGGCGTGGTGGTTCACACCTGTAACCCCAGCACTTTGGGAG GCTGAGGCGGGTGGATCACTTGAGGTCTGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCC CATCTCTACTAAAAAAATGGAAACATTAGCCAGGCATGGTGGTGTGCACCTGTAATCCCAGCTACTT GGGAGGCTGAGGCAGTAGAATCTCTTGAACCCAGGAAGGGGAGGTTGCAGTGAGCCGAGATCACA CCACTACACTCTAGCCTGGGCAACAGAGCAAGACTGTCTCAAATTAAAAAACAAAAACAAAAAAAACC CCACCATGTCTATACACCTCTGGCAAAGTCTTCCTGTAACCCCAGGGATACTTGACTCTAATTTAAAG ACTATAGACCTATGACATGGCTGATCAACTAGCAAAAAGTTATCACTCACCTTAATGAACAGTTAACT TAAACATTGAAAACCTCTTGTGTCCACAAGGTTATGTTAAATACTGGAGGTAGTGGTGTTATAGATAT TTTTTAAGAATTTTTTTTTTTTTGAGACAGTCTCGCTCTGTTGGCCAGTCTGGAGTATAGTGTGGCATG ATCTTGGCTCACTGCAACCTCTGCCTCCTGGGTTCAATCAATTCCTTGCCTCAGCCTCCCACGTAGC TGGGACTACAGGCACATACCGCCACACCCAGCTAATTTTTATATTTTTAGTAGAGACGGGGTTTCATC ATCTTGGCCAGGCTGGTCTTGAACTCCTAGACCTCATGATCCACCCTCCTCAGCCTCCCAAAGTGCT GGGATTACAGGCGTGAGTCACCACGCCTGGCTTCTTTAAGAATTTTTTTAAAATATGTATGTATGAGT

[1239] CACAATCTCTCTGCCTGAGCACCCATAGTCTCATTGGAGAACTTAGATAAGATACATATCACAAAAAG ATTAATAACCATACAAGGCAGTAAATGATCATCACAGCTAGTGGTGGGAAGAAGGACCATTATTACTT CTAGGTGTGTAAAGAAAGGTATGATAAGCATGGTTACCTTTCAGTTAGGCCTGATCATCTGGGTTTCA GGTAGCTAGAGAAGGGTGAGGGAGGGCATTATAAGCAGAGTAGGAGCAGCGGCAATAAAAAAGTTA AAAGTAGCTTTGTATTGGGATAGTCTTCTCTACAAATCCTGTTACTTACTTAACTGTATTATCTCGGGC AAGTTACTTAATTTATTTGAGCATTGGATTCCTTATCTGTAAAACAGAGTCAACACCAACCTTGTAGAA TTCTTTTTTGAGTATTAGATGATATCTAGAATCCAAGTGTCCCAACGTTTTTTGGCCTTTCAGGGCCAC CTTTTCC ACTG ATAG CCAAGTAAG AATACCTG AATTG CTGTCCATAATATATG ACTATAG G AACTCC A GATCCTTTCTCTCAACTTTGAAGACCCCTGTTTGAAGTGCTTTACATTCTCCTGGCTGTTGCTTGTCA CTTGTTGCTCCAACATATTATTCCAGGTTGCTCCCAAAATTCTAAGACTGCTGTCTTCCATTAAAATGA TGATGTTATGATGGTGTAGCTTCAGTAGGGGGCATTGTGAAAGAAAACTGTAATCCCCTCAATTCAGT AACTCTTTCCAAGGTTCATCCTTTAACCTCTACTACATAGAGGCCACATTGCAATCAAAGCTTTACTAA TGCCTGGCAGTTAAACAAGGGTCATTACAGCACCAAACAGGAAATAACACAATGTATCAAGCTTGGC GGTTTCTAAAATTCATCAGCTCTGCCCTGTAGCAGGGATCTTTTATGGGCTTTCTCCACTTTAGCCTC TACTCTCCCCCTGTTGCACCTATTCCCTCTAAGACCAAAAGCCCTTCTCTCAGGCTGTCCTCCCTGA GTCCCAAGACTCCTAACATCTATCCCTGCCTGCCCTCAAAAGAGGCAAAATATTAGGAAATTAAGAAA TTAGAAAAAATTATAAATCTCTGAATCCAGGGAAGACAAGCCTTTTTATTTCGTTAAACAGATTTTAGC TCCTAATGGCTTCCCCTTCTCTCCTCTGGCGGAGGCTCTGGTTTGTATAACCAAGTGGCCCATTAGC GTTTCCACAATAAAAGGGCTTAAGATGCAGATGCCAAAACGACTGCTAAAATGTTAACCTTTTTGGTT TTCCCTACACATATATAGAGGACTTAACACAACGTCCAACAACAAGAAGTGCTGAATAAATTTTTTTTT TTTTTAAAGTAAAGAAGAGGCACTGTCAGATCTGTTTTAGATGGTTACCCTGTGAGTGGGAAAATGGA CTGGATAAAGAGAGACCAAAAGCAGGGGAGCAATTAGAGAACCTTTGCCACAGTCCAAGGATCATG AAGATTTGAGCTTGCACTCCTTTTGTGGGTTTCCCACCATCTATGATGTGGCATTGGTTTTTTAAAACT TTTTATTGAGGTGTAATACATACATCGTAAGCTGTAAATGTACAGCTTATTGTGTTTTCAATGAGTGTG AAGTATATTTTTCAACTTATCTACAAGGTTGAATTATTTCCCTTTTTTTTCTCTCTCCAGATAATTTTTAT GGTGGGACGAGGATACCTGTCTCCAGATCTCAGTAAGGTACGGAGTAACTGTCCAAAAGCCATGAA

[1240] GAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGAGACCACTCTTTCCCCAAGTAAGTAAA AGCTTCATGCTATCCAAAAGAACAGACTAACATTCATAGACAGATTTCTGAGCACTTTTTTGGGCACA CAGTGTGTATTTCATGAGTTTGGATTCTATGTGCAGACTCCAGACAAGAAAACACATTAAGATGGCTT CATGAGGGTTGAGCAGTGGCACACCTAGAAATTTTGGGTCCTAATACAAAATATTCAGAAAGACTTTG CATTTGTCCATCAGTTCTCAGACTTCTCAGTCTTTGAACTCTTTTACACATTTAAAAATTATCGAAGAC CCCCCCCCCCACAAAGAGCTTTTGTTTATATAAGTTTTAATTCCTTATTAGAAATTAAAACTATTTTTTA AAATATTAATGAATTAAACATAGTAAACCAATATGTTAAATAATATTTAGAAAAAAACAGTTCTATTATC TAAGAGAAAAAAATTAGTGAGGAGTTGTATTGTTTTACTTTTTTTGCAAATCCCTTTGCAAAAAGAAGA CAGCTG G ATTCTCCG CTTTTG CACTCAC ATTG CAATATCTCAC ATCATGTCACCCCTAAAAACTCTAC TTAACGCTTGTAAAATAATGACAGTAAAAAAGGCAAATGATATCTTATTGTTATTACAAAAATAGTTTT GACCTCGTGGATCCCCTGGTGGTCCACGGACCACATTTTGTGAACCACTGCTTTATTTCTTCTTGGT GGTAAACAGATTCAAGCTTTCCTTTAATACTGGGTCTTTTTGAGGGGCATTTCTGCCTGATGCAGAAA AAGGAAAAGGCAGTAAGGCATTTGTCAGCTCAGCCTGCCTTTACCTAATTCTTGATAACTCACTGCTT TTTTTTTTTTTTTTCCATATTGGAAGGATAAAGCCTTAAGTTAACAAATTTCAAAAAGAACTGTAACTAA

[1241] GGCCAGGTGTCGTGGCTTACAAATCTCAACACTTTGGGAGGCCAAGGCAGGCAGATCAGTTGAGGT CAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAAACCGTCTCTACTAAAAATACAAAAATTAGCT

[1242] GGGCATAGTGGCAGGAGCCTGTAATCCCAGCCACTCAGGAGGCTGAGACATGAGAATCGCTTGAAC CCAGGAGGTGGAGATTGTAATGAGCTGAGATGACACCACTGCATTCCAGCCAGGGCAACAGAATGA GACTCTGTTTAAAACAAAACAAAACAAAAATATCTAAATACCTCAACTAGCTTACAGAGTTTAGCTGTA GTAGATATTATAATATAAATGCAATGTTTTCTGATACTTAGGGAGCTCCTGATAGCACTGGATAAATAT GCCTTGATGAATCAGTACAGTTTCAAGTGGGAAGTGCTATTTCCCATAGTAACCCTGCTACCATAATT ACTGGAGTGTTCATGTATGAACTCTTAGGCCTTTGAATGCCCAGTCCTAGCTGAGTAACTCAGACAG AAGTCAATGTTACAGGAATTAGATTCACTCATCCTTTATTTTTAAATCTAAAAAATGTTATTCTTCTCTA AAGAATGAAAGAAGATAAAATTGATGGTTTTAACAAGTCTGTCAGGGTGTTGCCTAAGAAAAGAAAGG GAAAGCTAAGTGGTTGGCTGGGTAGATATAAGTTTCATTTATCAGGTTTCAAAGTTACTGTTCCTTTG AGGAAGAGTTTTTATTTTTTCTTTTTATTTTTTTATTTGTTTCTCTAAGTCAGGAAACCTCTGGGTTGAG ACTGTCCTG GTG AG AG ACAAGTG CTG CTG AG CAG CTTCAG CATG ACCCTGTCCCATGTTCTCTTTTC ACGTCATGGTGCTCGGGTTCTTACTTAGAATGTTTATTGACATTAATAATGCAAAGTACATCCTTAGG CCCACTTTTTAAATGATATTAAAAGGGGCAAAATGCTTAGCTCCATACTTCTAAATATAACATTTCATT AATTACATGGTTTCAAAAACTGAAGTGCATATGTGAACTTTCCAGATTATTGGAGGCTATCCCTTTAAA GTGTTATTTTGAAATTTTTGTTACAGGATATCTTTTCACACCATACTGTTATATGCCACATAAATTTTAG ATGGCTGAAGATCTATATGTTTTATAAAATATGAAATCATTTTTATAGTTTTGAGGTAGGAAAGGCTTT CTTAATAGACAAAATTCAGAAGGAAAAAATTAGCAGATGTGAGTACATTAAAAATTTTTAAACTTCTAT ATAGAAAAATAACATTGAAAGATAAAAAGAATAATTGTAGCATATATAACAAAAAGTAAATGTTTATAAT ATACAAAGGACTCCTCCAAATCAATAAGTAACAAACAATAGAAAATGGGCAAAGGGAATATGAACAG GTGATTCACATAATAAATACAAATGGTGAATGAACTTAGGAAAAGGTGTAAATATTTCCATGGCAGTC AGTAAAATGCAAAGACACAACAGTGAAATATATTTTAATTTCGCCTCTCAGGTTGGTAATATCCAGCA CTGGGAACAATGTTGGGAAGTGAGGAGGAGCATTCTATGTAAAATTTTAAAGGTTTGGTGGAAGGCA GCATTTTGGAAGACCTTGGTAGAATCCATAAATTCAAAATACTTCTAAAAATCTGTGCTATGTAACCTA TTTCATAAGTATTCAGATATATATAAGAATGTTTACTATAATAAGAAAAAGACATTAAGATTAAGTTAGT TTTGTATTGATGACATGGATATTGGTGAGAGAAAAAGAAAACAAGACAGAAAACAAAATGTAGTATGA TACCTCATTTTTTTTTTTTATAGGCTGGGCCTGTTCTGTTGCCCAGGCTGGAGTGCAGTAATATGATC ATAGCCCACTG CAGCCTCAAACTCCTG GG CTC AAG CG ATCCTCTCACCTCAG CCTCCTAAGTAG CTG GGATTGCAGGTGCCTATCACCACACCCAGCTAATTTCTTGTGGTGGTGGTGGTGGTGGTTGTAGAG ATAGATTCTCACTATGTTGCCCTGGCTGGTCTTGAACTCCTGGCCTCAAGCGATCCTCTCGCCTCAG CCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCCCAGTGCCCAGCCTGATAACCACTTTAAAAGGT TAAACAGAGGCCAGGCACGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGC GGATCACCTGAGGTTGGGAGTTCGAAACCAGCCTGACCAACATGGAGAAACTCTGACTCTACTAAGA ATACAAAATTAGCCAGGCGTGGTGGCACATGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGG AAAATCATTTGAACCCAGGAGGCGGAGGTTGCGGTGAGCCGAGATCGCACCATTGCACTCCAGCCT GGGCAACAAGAGTGAAATTCCATCTCCAAAAAAAAAAAGTGGTGTTCAGGTGGGCCTTGTTTTCATG TATGTATTTTTATACATAAAAAAAGGTACTGAAGAGGCCAGGCGCAGTGACTCACACCTGTAATCCCA GCACTTTGGGAGGCCAAGGTGGGTGGATCAGTTGAGGTTAGGAGTTCGAGACCAGCCTGGGCAAA ATGGTGATACCCGTCTCTACTAAAAATACAAAATTATCCGGGCGTGGTGGCACACGCCTGTGATCCC AGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCTGGGAGGCGGAGGTTGCAGTGAGCTG AG ATCG CG CC ACTG CACTCCAG CCTG G ACAATAG AGTG AG ACTCCATCTCAAAAAAAAAAAAAAAAG GTACAGAAGAAAGTATAGACTCTAACAGTGGTTATCCCTGGAGAGCAGGATTTGAGAGCCTTATACT

[1243] CTTTATACATTTCTATAGTATTTTAATTTTTATTTGCATGTTATACTTGGAATTTACAATTTTTTGCAACT GCTTACTTCTTTGTCTTATACTAATCATCATAAAGATTACTTTTTAAAAAAAATTTAACTTTTAAAAACAA TTTTCAGCCAGGCATGGTGGCTCATGTCTGTAATCCCAGCCCTTTGGGAGGCCGAGGCAGGCAGAT CACCTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACGTGGTGAAACCCTGTCTCTGCTAAAAATA CAAAAATTTAGCTGGGCATGGTGGTGCGCTCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGA

[1244] GAATCGCTTGAACCCAGGAGGGGGAGGTTGCAGTGAGCTGAGATTGTGCCACTGCACTCCAGCCTG

[1245] GTTGACAACAGCGAGACTCCGTTTCAAAAAAAAAAAAAAATTGGTATCTCAGGACAATAACAAAAGTA

[1246] ATAATAATAGCTGCTAAGGTTTTATTGAGTGCTTATTATAGGCCAGGCATTATGCCAAGCCCTTTAAA

[1247] CATGTTTCATGATTATGAACATGCATTATCATGCTGTATGCCTTCAAGGATTATAACCTGTTTCTTTGT

[1248] GCCTTAAAATTGTGAATTTCTGCATTTTATATATTGGGGTCTATTTGTCGAGTTCTCCTATCTTTGCTC

[1249] TTGGGTTGTCCCCTGTCACTTCTCATGTGCTACTAGCACTCTGGGTCTGTGAGGTTCTGCTTTCAATT

[1250] AGGTGTATGTAAAACATTTCCCATGGCTAGGTTTCTTTAAAGGGCAAGTAGCTGTGATAATTCTGTTT

[1251] AGAGATAGTCATAAAGTGCTTTACTTATTTATACTCCATCTTCTTCCCAAAAGAGACTTGTGGTCTATA

[1252] ACAAAAAGGTATAAAATTGGTTTTAAATTTCTATTATTTACTGTTTCAAGACTAACAAATGATCTAAAAT

[1253] ATAAATAAAAGCTGACTAAGAATTACTCTCCCCATTTAATTTACAGAGAGAGTTTCTTCTTAAGAAAAA

[1254] ATACCAATTATTTACAAATATTTTCCCAAGCATTTATGACAATGCTGAAAACAATGTAAGATTTCAGGT

[1255] GCTTTCTTGTAAAGTGTGATGGGACTCTTAAAGATTTATACCACCCAGATTTTCATTCTTCTTTCTGTT

[1256] TTTTCTTTTTCTTTCTTTCTTTTTTTTTCTTTTTTCTTTTTTTTTCTTTTTTTTTTCTTTTTTTTTTTGTAGAT

[1257] TCTCGCCTCTATTGAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAGAACCCTCC

[1258] TTGAATCGGGCTGGTTTCCAAACAGAGGATTTTAGTCTATATGCTTGTGCTTCTCCAAAAACACCCAT

[1259] CCAGGCAGGGGGATATGGTGCGTTTCCTGTCCACTGAAACAAATGAGTGAGAGAGTTCAGGAGAGT

[1260] AGCAACAAAAGGAAAATAAATGAACATATGTTTGCTTATATGTTAAATTGAATAAAATACTCTCTTTTTT

[1261] TTTAAGGTGAACCAAAGAACACTTGTGTGGTTAAAGACTAGATATAATTTTTCCCCAAACTAAAATTTA

[1262] TACTTAACATTGGATTTTTAACATCCAAGGGTTAAAATACATAGACATTGCTAAAAATTGGCAGAGCCT

[1263] CTTCTAGAGGCTTTACTTTCTGTTCCGGGTTTGTATCATTCACTTGGTTATTTTAAGTAGTAAACTTCA

[1264] GTTTCTCATGCAACTTTTGTTGCCAGCTATCACATGTCCACTAGGGACTCCAGAAGAAGACCCTACCT

[1265] ATGCCTGTGTTTGCAGGTGAGAAGTTGGCAGTCGGTTAGCCTGGGTTAGATAAGGCAAACTGAACA

[1266] GATCTAATTTAGGAAGTCAGTAGAATTTAATAATTCTATTATTATTCTTAATAATTTTTCTATAACTATTT

[1267] CTTTTTATAACAATTTGGAAAATGTGGATGTCTTTTATTTCCTTGAAGCAATAAACTAAGTTTCTTTTTA

[1268] TAAATTTTGAGTGCAGGTGACCAAAAATATTGCTGAGGAGTGGCACGTTTGACATGAGTAAAATGTCT

[1269] TAACTTCGGATTTTTAGCGGGAAAATGTTATAAATTGGAGTTTCTTTTAAATAGCTTTTTTTAAAATACA

[1270] TTAAGGATGTCTCGCTCATGTAGAAGTCAAATTTTGTTGCAAACGCATTGCTCCCTTCACACCCAATC

[1271] TCTCCCCTGCAAAAAATCTTCACAGAATTCTGTGAGAACTTTTAGGTGTGTTTTTCTTTGAGATACCTC

[1272] TGGTTGCCAAACACCAGGTAATAGATTTTTTAAAGTTGTTATTAGATTATTCTTACCTCTCATGATGCA

[1273] TATTTTAGCAATCACCTTATCATTGTGTCTCATGTTCTGTCCTCCTTATATTCTTTGCCCAGCAAGATT

[1274] CTACTTATGATGAATGAATGCTCTTCTCCTTTTTTCATTCAATGGTATGAAGTATTTGTTAGGGTTCTTT

[1275] AGTACTTACACTTTGTTGTGTAGAAAATGACTGTAATGTGGTGGTCAGTGTATTCTTACTGTGATTCA

[1276] GAGGGAATCAAAAGTAGAAAGCAACAGCACGTGGTCCTATCAAAGATTTGGCCATCTCTGCTTCACT

[1277] GTCAGCCTCTTAACTATATCTTCACTTACTCAATTTGGTTTTGTCATGATTTTTAAATGTAGCCAATAG

[1278] ATCAAGGTTCTTCCAGTAAACACATATCTGCATAAATGCCTCCTTGAAGTCAATAAAGAAGGAAATTG

[1279] AGAAGACTTTAAATTAATGATAATTTAGTTTTTAAGTACCCACAAATAAATTTTTGAAACATTTTCTTTAT

[1280] TTGAATACTTAGATGTCATCCAGGAAAATCACTCAATAATAATTACGGCAAATCTTTAACCCCTCATTT

[1281] GGGTAGCTTAAGATAAGTAATGCCATTATGAATCAGAATTGATTCATGACTTTAGTTAAGAAAATGAAA AGGAACATTTCACGTATTTTTAAAAATGATACTAAGGAATAAAGAAGTACAACTATTGGAAAATATCTA AGTATATGATTTTTAAATCCTCCAGTGGCATTAAATATATGATTATTAGTAATTGTTAGATAGGGTTTTA TTCATTCACAAATAGAAGACTAGCAAGCATGTAACTAACAAAGTTTTTACAAAATTGACTTTGTGGAAT

[1282] GCTCCAAATGTTTGGCCATTTTGAGGCACAAGGTCAGGGGTCTCTTTATTGATAGAGCTCCTTCTATA

[1283] ATTTCCCAGCATACCTGCCTCACAGTTATCTTCCTTTCATTGTTCACTCTCTTTTTCTTCTCAATGCCA

[1284] TCCTGCCTAGGCTCCCATCATCTGCATCTGACACCTTTCCTTTCTTTCTTTACTAGTCTCCTTTGCGAT

[1285] GGGTGTGGCTAAGCTCTGTAGAGCCACTCAGAAACTCATTGTTCCATTCTGTAGCCAGTAAAACATG

[1286] CCTCCAAAGTGTCACAGAGTAATTCTACTCTCTCTTTTAAATTAGGTCCACCGGAAATGTTAGTGAAA

[1287] GGACATTAAAAATGTGACAGGTGACATGTTTAGCTAACATGGATCTGGAGAAATAGGAAGCAGTAGA

[1288] ATTAAATGTTTCCCTTTCAGGTTTAATTGTATTTGTTCTTGGGTTTTGTTTTATACTGAGTTTTAAATAT

[1289] ATTCTCCAAATAAAAACATTATTTTTTCTAACCATATGTAGAGTTAATCTCTTTGACTAAGTAATTGAAA

[1290] CAAAAGAACATTTGTTCTTTTGTGACTGCTTTTTTCCTAAAACCTGAGCCCTCTTTTTTTTTTTTGAAAT

[1291] TAAAGTTGATTTCCTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCGCTC

[1292] TGTCGCCCAGGCTGGAGTGCAGTGGCGGGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCA CGCCATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCGCCCGCCACTACGCCCGGCTA

[1293] ATTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTTTTAGCCGGGATGGTCTCGATCTCCTGACCT

[1294] CGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCCGGCC

[1295] TTAAAAGTTGATTTCCTTCTTCAGTAAGGAAACCTTTTTATAAATTTGTTTTGCATTTTAAAAGTTTTAC

[1296] TAATC AATG ATG AG G AAAAAG ATTTGTCTTCTTG ATTTTAAATAGTTTCAG G ATCACAG G ATGTAATCA

[1297] GATGCTTCCAGTTTATTTATTTTCAGGTATTACACTAGCCATTTAATCTTTTTTATTTATTTATTTTCTTC

[1298] CTGCCCCTCGGATGGCATATACCAGCCATTTAGATACTAAACTCTAATAGTTAAACCAATAGTTAAAA

[1299] TTGTCCTCTCTAAAACATTGGCTATTTAATATACCAGCTTAAATGGCCTTTCTCTCAAGTGAGTCACTC

[1300] TTAGTTTAAGAAAATTATGTGCCTTTTTAAAAAATATTATGAAATGGTACTTCATGACAGAAACATTTTA

[1301] TCAGTTATAGTCTTATTTGATTGAAAATTGTTGAGCATTTCTGTAAAACTTTTTACTTTACTAAATATTT

[1302] CATCTTTCCTGTGACTGTTTTCTCAAAGAATTTAAAAGACTCGATGTGTCTATGCCAGAATGTTTCTCA

[1303] TCCTTTTGAAACTGCCTGGGCCAGGCGTAGTGGCTCACGCTGTAATCCCAGCACTTTTGGAGGCCA

[1304] AGGTGGGCAGATCGCGTGAGCCCAGGAGTTTGAGACCAGCCTGGACAACATGGCGAAACGGTGTC

[1305] TCTACAGAAAAATTTAAAAATTAGCCAAGCATAGTGGTGCACAACTGTAGCCCCAGCCACTCGGGAG

[1306] GCTGACGTGGGAGGATCCCTTGAACCTGGGGGCGGAGGCTGCTGTGAGCCTTCATCATGCCACTG

[1307] CACTCCAGCCTGGGCAACAAAGCAAAACCCTGTCTCAAAAAAAGAAAAGAAAAAAAGAAACTGCTTG

[1308] AAAGTCATGACGAAGAATGTCAGGAGGGGACTTATTCTGGCTGCAGTTGACTTTCTCCTTAAATGTC

[1309] AAGTAGTGATTGATTTGGATAAGAAGTAAACTGTTACTTTTCATAACATACTTTAAGGAATTTATCAAA

[1310] TTCTATGTATAATGCCCATTAAAATATACTCCATTCTGGAGTAAAGGGTAAGAGTAATATTTTTAAACT

[1311] AGTTAATAAAGTCTTTAGCTTTCACATAAACCATGATATTTGAGGTGTCTAAAATCACAGGGTCTTTTT

[1312] TTTTTTTTTCAGTCTTCCCAGTTGTTCTCTGCTCTATTCCTAAATAAAGTTAACTTGAAAATGCATGGC CGGTTGTGGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGTGGATTACTTGAG

[1313] GCCAGTTCGAGACCAGCCTGGCCAACATGGCAAAACCCTGTCTCTACTAAAAATACAAAAATTAGCT GGGCATGGTGGTGTGCACCTGTAGTCCAGCTACTTGGGAGGCTGAGGCACAAGAATTGCTTGAACC

[1314] CGGGAGGCAGAGGTTGCAGTGAGCCAAGACTGCACCACTGCACTCCAGCCTGGGTAGTAGAGCAA GACTCTTTCAAAAAAAGAAACAGAAGATGCAGCTTAAATTATCCTCAACCTGAAAGAAGGGGAAAGAA AATATTTCAATTTGGCCTCAAATTGATTTTTTTTTATTAATTAATATACCAAGATTTTTTTTAAGACATAG AGTATCTAGGTATTTCACTTCAAATAACTTCACACAAGCAGAGTTGGCTCTTCAAATAGAAGACGGGT AGGAAGTAGAATAGTAGAGATTTCCAGATGGGCAAGAAGGAATCATTAAGAAAAGATACTTTTTGTGA AAGCAGATTCATCACCTGTTACTCCCATGTTTTCCTTAAATTCTCCATGTTTTAGGGACATTTTAAGAG TCTTATTTTATTGATTCCTGAACTATGGATTCTTTTATTTTTTTCCCCTCAACACCAAGTATGACTATAA AAAG G ACTG C ATTCTGTTAG AAG CACTAG ACTTTTG ATAG AGTG ATAGTGTTTG CTTTGTATTTG ATTT GGAGTTTGTTGGTAAAAATTTGTTCTTTGTGCGGTTGTTTGGTTTTAAATTTTTTTGGAGACAGAGTCT TGCTCTGTCATTCAGTCTGGAATGCAGTGGTGCAGTACCACCACACCCTGGTAATTTTTTTGTTTTTG AGACAGAGTCTCATTCTGTTGCCCAGGCTGGAGTGCAGTGGTGTGAGCTCAGCTAACTGCAGCCTC TGCCTCCCGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGAATTACAGGTATGTGGC ACCACACGTAATTTTTTTTTTTTCCCAGTAGAAACAGTTTCACCATGTTGGCCAGGCTGGTCTCGAAC TGCTGAGCTCAGGTGATCTGCTCACCTCAGCCTCCCAAAGTGCTGGGATTACAGGCTTGAGCCACT GCACCTGGCCCTAATTTTTGTATTTTTAGTAGAGAGAGAGTTTCGCCATGTTGGCCAGGCTGGTCTT GAACTCCTGGCCTCAGATGATCCACCCTCCTCCGCCTCCCAAAGTGCTGGGATTACAGGCATGAGC CACCTCGCCGGCCTGGTTTTTATTTTTAAGACTAATATTTAAGTTTGTGGAGTATGACACTTCAACAAA ATGAAATTTCTAATCATTATAATGAACAGGAAACATCTGAAGTTGTGTGCGTGTGTGTGTGTATTTTGT TTTGTTTTCGAGACAGGGTTTCGTTACTCAGGCTGGAGTGCAGTGGTACAATCCTGGCTCACTGCAG CCTCAACCTGCTGGTCTCAAGTGATCCTCCCACTTCAGCCTCCTCTAGGTAGCTAGGACTACATGCA TGTGCCACCACATCCAACTGATTTTTTTTTTTTTTTTTTTTTGGAGAGACAGCGTCTCACTATGTTGCC CTACCTGGTCTCAAACTCCTGGGCTCAAGCAGTCCTCCTGCCTCGGCCTCCTGAAGTGCTGGGATT ATAGGCGTGAACCACTGTGCCCAACCTTAGCTGAAGATTTTTTTAAGTATTTTTTAATGTAGTATATTA ACATTTGGCTTAGATATTAGCATTTTCTGATTTTTTTATTTAATAGATTAATTCTAGGCATTTTCATAAA GATTTCTTTTCTATAAATCTTATTTTTACATTGACTTCCTTTAATGAGATTTGATTTGGCTAGATACATG ATTACTCATAAGAATGTTGCAAGTCATTTTAAAGAAACATTAAAACACTAAAAATAGCAACCTTAAAAT TATAAGTACTCAAACTGTAAGCAACAATAGTAAGAATGTTTGTATATTTCTGGAGTGTGTTACCATAAT AGCCTCCTATGATTATACTCCAAATGTTTTACTCTAAGGTCTTAGTAATTTAATTTAGCCTTTTTTTTTT TTTAAATCAGTGCTAGATTCCCCAATCCTCTTAACTTTAAATATGAGGCAATAATTCTTTTACCCTTTCT TGATCTTTGGACTCACAATACCTTAGTTAATTGCTTGTTAAAAGGAATTCATGCATAGAAAGAGATAAT AGACTATCTGCAGTTCATTAGTAGTTGTATTCAGATTGGGAAAACAAAGTGTTAATTGTTGAAAGTTGT TTAGGGACTGCTGGGTCTTGGAGTCAGCACCTGGGTTTGCATTCCTTCTCTGCAATTTTCTGTATATG ATCTCAGGCAAGTTACTTGACCACTCTAAACCCTGGCTTCCTCATCTATATAATATAGATGATAGCAT CTGCCTCATAGGGTTATCATGAGAATTGGATGCAGATGTGTACAAACTGTTCCGTGAGGCATCAGGC ACTCAGTCAGTCACTAATACTATCAGCTTACAAAGCTGAGGATTCAATCATCCAGTCATTAGCAATCT GTTGTTGGGATGTGCCAGTGTTATCTAGCAACCAGTTGGAATCTGATAGCAATCAGAAATTAGATAG

[1315] GTTATTCCTG G ATTAAACAGTATATTCATATAAGTG ATTG CTTGG ATCCTCATC AG AAG CTG CTATTG A AAAATAGTGATATGGCTGGCCGGGCATGGTGGCTCATGCGTGTAATCCCAGCACTTTGGGAGGCCA AGGCGGGCGGATCATGAGGTCAGGAGATAGAGACCATCCTAACTAACACAGTGAAACCCTGTCTCT ACTAAAAATACAAAAAAATTAGCCGGGCGTGGCTTCATGTGCCTGTAGTCCCAGCTGCTGGGGAGG ATGAGGCAGGAGAATGGCATGAGCCCAGGAGGCAGGGCTTGCAGTGAGCCGAGATCGCACCACTG CACTCCAGCCTGGGTAACAGAGCAAGACTCCGTCTCAAAAAAAAAAGAAAAATAGTGGTATGGCTGA CTAAATTTTGTTAATTGTCAGTTATTAACTAATCCCCAGAAATTAACTATGGTGTGTATAACAGGAATT GGCCTTTAGTTACAAGTAGAAACTATGGACAAAATGGTAGATGAAAAATAATGGCGGCCGGGTGCAG TGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGCAGATTACCTGAGGTCAGGAGT TTGAGACCAGTCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCAGGCCT GGTGGCGGATGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCACTTGAACCCAGGA GGTAGAGGTTGCAGTGAACCGAGATTGCACCATTGCACTCCAGCCTGGGCAACAAAAGCAAAATTC CATCTCAAAAAAAAAAAAAAAGAAAAAAATAATGGCATGAAGCCCCCAAATTCATTAAGCTAAAGGAG CATGATATCACAAAGGTACTTTGTGGTTTAAAGAATTCTTTATGCTGATAATTATGTTCAGTGATGTGC CTATATTTAATTTTTTGTTAGATTGAAGGTGAAATTAACTAGAAAATAGGCAGTCTGGATTTTCTTTCTC TGTCAAACGTGTGGTGTGAACAAATCAGTTGACCTCTTAATTGTATCTTTAGCAAAATGAGGATAACT ACTGCCTCTCTCTTCCTAATAGTGGCATTATAATAATATGATAGGTGAAAATGAGTTGATAATTCAGAG GTGGAAGTATTCTACAAATTGACATTACTACTTTACATTCAGTTTCTGAGAAATTTTGTTCATTGGAAC TGTTTTCAGCTTGATCAGAACCATGATACATAAAACCCAACTGGAAAATTCTGCAGACTTGCTATTTAA TTGATAGAGCTGAACCATATTCTGTATACTATATATGTTGTGTTCTTCCATGGGTTTCAGCCGTTTTTG CTTTTAAATTAGCAATGCTGTTGCTAGACTTGAAATATATAACTAGTTACTTTTCAGTGAAGCTCAAAT GAGGCTTTTCTGTGTCTCTAGGTTATTTGAGATGACTTTTTTAAAATTAGCTCTTGTCCTCCCTCTACA GGAGAATTTGCAGCCTTCAAGTAGCCACCATCATGGCAGCATCTGCTCTTATTTCTTAAGTCTTGTGT TCGTACAATTTGTTAACATCAAAACACAGTTCTGTTCCTCAAATCTTTTTTTAAAGATACAAAATTTCCA ATG CATAAG CTG ATGTG G AACAG AATG G AATTTCCCATCC AACAAAAG AG G AAAG AATGTTTTAG GA ACCAGAATTCTCTGCTGCCAGTGTTTCTTCAACAAAAATACCACGAGCATACAAGTCTGCCCAGTCC CAGGAAGAAAGAGGAGAGACCCTGAATTCTGACCTTTTGATGGTCAGGCATGATGGAAAGAAACTG CTGCTACAGCTTGGGAGATTTGCTATGGAAAGTCTGCCAGTCAACTTTGCCCTTCTAACCACCAGAT

[1316] CAATTTGTGGCTGATCATCTGATGGGGCAGTTTCAATCACCAAGCATCGTTCTCTTTCCTGTTCTGGA ATTTTGTTTTGGAGCTCTTTCCCCTAGTGACCACCAGTTAGTTTCTGAGGGATGGAACAAAAATGCAG CTTGCCCTTTCTATGTGGTGCGTGTTCAGGCCTTGACAGATTTTATCAAAAGGAAACTATTTTATTTAA ATGGAGGCTGAGTGGTGAGTAGATGTGTCTTGGTATGGAGGAAAAGGGCATGCTGCATCTTCTTCCT GACCTCCGGGGTCTCTGGCCTTTTGTTTCCTTGCTCACTGAGGGGTCTGTCTAACCAAGCAGGCTAG ATAGTGCTGGCACACATTGCCTTCTTTCTCATTGGGTCCAGCAATGAAGATAAGTGTTTGGGTTTTTT TTTTTTCCTCCACAATGTAGCAAATTCTCAGGAAATACAGTTTATATCTTCCTCCTATGCTCTTCCAGT CACCAACTACTTATGCGGCTACTTTGTCCAGGGCACAAAATGCCGTGGCAGTATCTAACTAAACCCC CACAAAACTGCTTAATAACAGTTTTGAATGTGAGAAATTTAGATAATTTAAATATAAGGTACAGGTTTT AATTTCTGAGTTTCTTCTTTTCTATTTTTATTAAAAAGAAAATAATTTTCAGATTTAATTGAATTGGAAAA AAACAATACTTCCCACCAGAATTATATATCCTGAAAATTGTATTTTTGTTATATAAACAACTTTTAAGAA AGATCATTATCCTTTTCTCTACCTAAATATGAGGAGTCTTAGCATAATGACAAATATTTATAATTTTTCA ATTAATGGTACTTGCTGGATCCACACTAACATCTTTGCTAATAATCTCATTGTTTCTTCCAACTGATTC CTAACACTATATCCCACATCTTCTTTCTAGTCTTTTATCTAGAATATGCAACCTAAAATAAAAATGGTG GCGTCTCCATTCATTCTCCTTCTTCCTTTTTTCCCAAG CCTG GTCTTCAAAAG GTTG GG CAATTTG GC AGCTGAATTCCCAGACAGAGAATAGAGCAATTTTAGGGATATTAGGACTGAGGGAGGGTGTGGGAA AGCTGTCATCAGTTGTTTTTATAGAAAGAACTGGCATTCATTAAGAACCTAAATCTTATCTTTGCACAA ATGGAAAATATAACCTAGTTATAGCTTCCTTTGGCCTTTATTAAAGGGTAATATCAATCACAGTCATAG CAAAG AAAG CG G ATGTATTAATG G CAAATTAATGG AAAACCTCCCTTATCAG G AATCTAG ACTCAG AA TTTAGGAACACAAATCAAATCAGACCAACCAAGCTATAGCCAAGGACTTGAAAGAAATTAAACAAGAC CCAGAATAAATCAAGGAATTAGAAATTGTTATTTAAAAATTTCAGATTGTAACTCCAGGCCCTGCTGTC TATATTG CAG CCACTAAAAG CTCACTACCATTAG ATTTTTG CTAACATAC ATGTATTCAG AAG AAAGCC TATTGAAATTTTCATTGTCTTGTAAAAGGTTGTCCTAGTAAAATGGAAAAGATCCTTAAGTTATTAATC AGTTTGAAAAGCAAATTTGTTTTTAAGTTTTACATCAGCAGGGCAGTGTCTTACAAAATTCAGAAATTG CAAAGGTGGAAATAATTCACGCTGATTTGAAGAACATCTTCTGTGCAATAATACTGCCTCTCTTGAAA AGCATTGGCTGTTTTTTCTTTTTAAATATATCTCTAGATGCTTTTAAATGTGGCTGTGTTCCCTTTACCA AG ATTGG CTTCAAGTTTCCG CAG GTAG AG AG ACCTGG GCTTG AACAAG AG G ATGTGTTTCATGTCCT GCTGAGGAGGTAGAACATGTGCAGCCTGGGTCCGGGACTGCCTCCGTGGGGCAGGGGCAGGGGC GGTACCATTAGGGAGGAAGCTTAGCATTTCAGTTTCTTAAACAATATTCAGGGTGATACACTTTTTCT TCCCTTGCATTTTAGAATAGGCTGGTATCTCATTTGAACGGGGGAGCAGACTTGATCTCAAATGAAG CTGTG CCCAG G AGCC AG G CTTAG CATATTG AG ATTTTTATAG ATACCTTAAAAAATAAAATATTTAAAC CTCTCTTTTCTTCCTTTTTCTATGAAATAGGTTTTTTCTCTAGTTTACAAATGACATGAAAATAGGTTTT ATTTGTGTTTTATCTGCTTTATTTTTTGATGCTTAGACAACAGTTAGACTTACTGAGCTCCTAAAAAAA CGAGGAAGAAGTCCTTATTTGTGAAAAGCACTTTATGAGTAATTGTATAGACAGTATGTGGCTGCGTC ACTGATCATCTTGTAAGGGTGTAACAGTCTTGTCTGTAAAGTGGCTGCAGTGCCTTCTGTAGTGTGTT TTATTTTTGGTAGGGAGAGGTGAAGCCTTCTGAAAAATTTGAGAGCAACTACAGAGGATTGTTTGTAA CTGTGTAGTATTCCTGATGGACTTTTTTCATCGTTAGAGTCAAGGACCTAGACTTTTGCCACTGAAAT AATATTGACCAAAAAAATAGTTTATAAAAGGGATTTGTGAATAGAAAATTCAGTGTGATCATTTGTTGT TAATGTGCACCTTAAAAGAAGATTCTGTCTAGCTGTCAAATTCTGGTTCCCGAATATCTCACCCCTGA TTGTATTTGAGATCTAGTAGGGCATACTGGGGCATTTTAGAAGATAAAATCCCATACAAATGATATAT GCTATATTTATGTTGGTGTTGGAGAAGAAAGAGCAGTATATAAAGAAATAATTCAAGACTGCAGCACT GTCAACCTGAAACTTTGTAAATATTTCCTAGCTTCTGGTTTGGTGCGGTGACAGCACTTTCATCACAG GATGTTACCTTGTATTCACCAGGCGGAGTGCGAGCTGCTGCACATCCTCCTCAGATCTCACCTGTCC CCACTGTACATCCACCCGCCAGCTGCTTGCAAACCTCATCTCTAGCTTTAGTTCGAAACCACATTGC AGGGTTCAGGTGACCTCTACAAAAAACTACCTCTTCAGAATGAGGTAATGAATAGTTATTTATTTTAAA ATATGAAAAGTCAGGAGCTCTAGAACATGACGATGATTTAAGATTTTAACTTTTTTGTGTACTTGTATT TGAGCACTCTCATTTTGTCCTAAAGGGCATTATACATTTAAGCAGTAATACTGTAAAAAAATGTGTTGC TCGGAATATCTGAATGTTGTTGAAAGTGGTGCCAGAACCGGTTTAGGGGTACGTTTCAGAATCTTAA CCTTGAGTCAATTGCATGAAATTAAATAGCTGTGGTATCACTTCACTAACAGTGATGTAATTTTAATTT TCAGTAGGCTTGGCATGACAGTACATCCTCATAATGAGTTTGCTGCAGCTTTGTCACATGCACAGGC ATTCATAGAAAGACCACCCAGCTAAGAGGGTAGAATGATTACTCTTTTTGCAAGATTCTCTTCTTTGT CCAAGTTGGCATTGTTAGTGCTAGGAATACCAGCACCTTGAGACGAGCAGATTCCAACCATTAGGCT

[1317] ATAAACACCATAGCCAGAGATGGAAGGTTTACTGTGAGTATGAACAGCAAATAGCTTACAGGTCATG AGTTG AAATG GTGTAG GTG AGG CTCTAG AAAAATACCTTG ACAATTTG CCAAATG ATCTTACTGTG CC TTCATGATGCAATAAAAAAGCTAACATTTTAGCAGAAATCAGTGATTTGTGAAGAGAGCAGCCACTCT GGTTTAACTCAGCTGTGTTAATAATTTTTAGAGTGCAATTTAGACTGCATAGGTAAATGCACTAAAGA GTTTATAGCCAAAATCACATTTAACAATGAGAAAACACACAGGTAAATTTTCAGTGAACAAAATTATTT TTTTAAAGCACATAATCCCTAGTATAGTCAGATATATTTATCACATAGAGCAACTAGGTTGCAAATATA GTTCAGTGACATTTCTAGAGAAACTTTTTCTACTCCCATAGGCTCTTCAAAGCATGGAACTTTTATACA ACAGAAATGTTGACAGAAATTGCTGTAGTTTAGGGTTGAAGTACTGTATGATGGGCAGCAATCATGTA TTAACTTAGAAGGGGAAATTGAAATATAGGACCGAATTTGGTTTTATCAGTTTCCAGAGTACTGCTGC CAACCTAGACACTGATTTTTCAGAGTTTGAAATGTAAATTTCTTCCCGGGACTTGATTGCACATGAAG CTGGACTGCGTTAGTCATCCTGTCCCAAAGCGCTGTGGGGGCCAGGGTGGAGGTCTCAAGGCATC CTTTATGACCTGGCCATTGGATGTAAAAGAAAACATATTCCATGCTGTGGTTCTTGTATCTTGTTTCAT TCCTCACCATTGAAAGAGAAAGTCCATGTATTGTCTCCAGCACATCCTTGAAATGTTATACTGGGATG GATTACTGATGCCCATCGGTAGTTGAGCCCCAGAAGAGGGTAGTAGCATCTCTGCCTCAGGTGATG ATTTGTAGCTTGGCCAGAGGAGAGCGGAGTCACCAGTATATCTGTGGTCCATGTTGCTAGCTCTGGT AAAATTAAAAATACTGGTAAGATGTTTGTTTTATTAGTACACTAGACAGTAAGCTCTGTTTTGTTGTTTT CAAATAACCTATTTTCACTTTTGTTTGGGCAAAGACATTTAAATTGAAATTCAATTCTAATTTTTGTTAA TTGTGGAAAGGGTAATTAACAGTTCCTATCAGGTATTTTTAATGTGGAAAAGGACAGAAACCCAACTC CTAAAATCTTAAATTAAG G TAAC AGTG CTTTAAAAAAAAAAAATG C ATG G G G C AATTAGTCG G CAACT CAATGAGTGACTAAAGTACTTTTATTTAACATCCACAACTTCAACTGTTAAGTTTTATTAATTACTAAAT CAGCTTTATTAAAATGTTGACATTTATTTAGCTATTTTGAATAATTATAGTGACTTGACGAGTGTGTAT GAGGACACAGCCAATGTAAGCCAGTGTATCCATTTTTTAGAGGTGCATTTTTTTTTAAAGAATTCTGTA GATAGAAGTGCTCTGAAAACAACTAAAATATGTTTATTCATGGTAGTATCAAAAAATGTTTGTACAAAC CATCTGCTTCTCCCGGCCAGCCGAGTTCATTCTCCAGCACCGTGACCGCTGGTTCTCATGTACAGCA CATATGCGGGAGAGTTGGCAGAAAATTTGTGAAGAGATGCCGCAAAGGAAGGGTCTGTTGACGGGT GGGATTGGGGGTTTTGATGAAGTTGCTTAGTCCTGGTTTTGTTTTGAAAATTACTGCGTTGCATTTTT

[1318] GTGTTAAGTTTTTGAACCCACGTGTGTTTTGGTGGAGTATGAGTTGGAAGTCACTGCAAACTAGCATA AACAACAAAGCTCACAGAGTAGGCACAGATGTAGAGAACAGAGACCAAAATGGGGTGAGGTGGCAG TAAATCTAGGATAGGGAAAAATTAATGTGAGGGTGGGAAATAAACTGTAATTACCTGAAATCAAATGT AAGAGTGCAATAAGTATGCTTTTTATTCTAAGCTGTGAACGGTTTTTTTAAGAATCATTCCTTCCTAAT ACATTTGTGTATGTTCCATAGCTGATTAAAACCAGCTATATCAACATATAATGCCTTTTTATTCATGTTA ATGACCAACGTAAGTGGCTAGCCTTTATGTCTTATTTATCTTCATGTTATGTTAGTTTACATACAGGGG TGTATGTCTCTGTGCTGTCCCCTTCTCCTGCCTTCATTTTAAAATGCATCCATGGGTCCTCCGTGTTT CCTTTGGCCATGCCACATATATAGACTCAGTTTGGCCTTCATGATATCGCCTGATTTTTGAGGACTGT ATCACAGTGATATGTATTTGTGGTAATCTCATTTGTTGGTTGTACATCTGATCCTTTCCTCAACATGGC AATTG CTG CCTTTCCTAAG ATAG G ATC ATACAACTG ATCAG GG G ATTG AATTTG ATCATTCATCAACA TGTGTCTCTGAATTTTATTCAGTAGTTGTCATTGCTCTTTGGTTTAGACCAAGAAAAAGGAAATCCCC CCTTTTCATGTATTCCTTGGTTTGAGGACATGACTCCTGTAAGGGAGAGGAAAGGGAGATGCTTCCT GTTTGAACTGCAGTGAATTCACGGTTCCTGTTTCACCACTCCAAACCTTATGGCGACTCACACACACA TTCCTCTTTTCTGTTACTGCCAAAGGTTCGGGTTTAGTACACTTCAGTTCCACTCAAGCATTGAAAAG GTTCTCGTGGAGTCTGGGGCGTGCCCAGTGAAAAGATGGGGACTTTTTAATTGTCCACAGACCTCTC TATACCTGCTTTGCAAAAATTACAATGGAGTAACTATTTTTAAAGCTTATTTTTCAATTCATAAAAAAGA CATTTATTTTCAGTCAAATGGATGATGTCTCCCTCTTTTCCCCTATTCTCAATGTTTGCTTGAATCTTTT ATTATTTTTTTTAATTCTCCCCCATACCCACTTCCTGATACTTTGGTTCTCTTTCCTGCTCAGGTCCCT TCATTTGTACTTTGGAGTTTTTCTCATGTAAATTTGTATAACAGAAAATATTGTTCAGTTTGGATAGAAA GCATGGAGAATAAAAAAAGATAGCTGAAATTCAGATTGAAGAAATTTATTTCTGTGTAAAGTTATTTAA AAACTGTATTATATAAAAGGCAAAAAAAGTTCTATGTACTTGATGTGAATATGCGAATACTGCTATAAT AAAGATTGACTGCATGGAGAAGTCTTCATCAAGACTATTTTTCTAACACGATTACATTCAGTAACAAAA GTAGTCAGCAGTTTTAACAGTTTTTCTAGACAATGGAGAGACTGAGAAATGTACATTTTGTTTCATACA TAATGTTGGTTACTGCTTAGTGGGTAGAAGTTCAAGTAAGTTGTCAAGTTTCATGCATGGTAGGTTAT ACGTGCTATACAACTTGCAGTGGCAACAGTCGTTTGTCAGGTGTTGGTGATGACCCTTAAATATTTGA GATGTTGTGACCTGATGTATCTTTAGTTTCAAACCACTGCTTTCCTCCATGTGGTTCAGTTGGAGTAT GTGCTCTACTTTAGTCATGTTTAAAGTTTATCTGCAGAAACTCACCTTAGAATTGTATTTTTTCAAACTT TTGACAGCTTACATTTTCTATAGCAACACAGCACACGCACGCTAACATTTACTTGAAACTATGCACTC ATGTTTTCTACTTCATTTTTTTTTATGCTGGTTACCTCAGTGAGTTGATTTTCTGCATTTGATTTCATGA CCCTTCCCCAAATAAAATTCACTGAAGTCTGAAAAACTCCTAGAGTATCTTCAGACAAAATATATCAAA TTACTGGGCAGAGTTTCCAGAAAGGAAGTAAACCGTTTTAAAACTCATCTGCAGCCAGGTGCAGTGG

[1319] CTCACGCCTGTAATCCCAGCAATTTGGGAGGCCGAGGCGGGTGGATCACCTGAGGTCAGGAGTGG AGACTAGCCTGACCAACATGGTGAAACTGTCTCTACTAAAAAATACAAAAATTAGGCCAGGTGTGGT GGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGCAGATCACCTGAGGTTAGGAGTT CGAGACCAGCCTGACCAACATGGAGAAACCCCCTCTCTCCTAAAAATACAAAATTATCCGGCTGTGG TGGCGCATGCCTGTAATTCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGGAGT G AG CCG ACCG AG ATTGTG CCATTG CACTCCAGCCTG GG CAACAAG AGCAAAACTCCATCTCAG AAA GAAATAAAAAAAAGCTGGGCATGGTGGCCAGCACCTGTAATCCCAGCTACTCGGGAGGCTGAGGCA GGAGAATCGCTTGAACCTGGGAGGCGGAGGTTGCAGTGAGCTGAGATCACGCCATTGCACTCTAGC CTGGGCAACAGAGCGAGACTCTGTCTCAAAAAAAACACTTCACCTGTTTATCCTTATGTCTGAGAATA ATATG AAG G AACAG AAAAG CCTAAAAAGGG CTTGTG CCTG AG G AATCTG GTTTCACCCCTCCTCCC A AACAATAAAATGTTATCAAGACTTAAAAGGCTAAGGCAGGAGGATTGCTTGAGCCCAGGAGTTTGAG

[1320] GCAAGCCAGGGCAATATAGCAAGACACCCACGCTAAAAATAAAAATAAATGTCAAGACTTAATTTCCT ATGAACTGCAGTTTTTCTCTTCTGAAAATGGTAATTCTATAATATAAACATCATAGAAATTCATTTTCTA AACCTTCATGTGTGATTACAACAGAGTAGATGTGGCTTTAAGAACATACTATACCATATATGTGAGGT TTTCCTTAAAATTTAGCCCAGAACTATGGACACTTTGGTTATTATAAAGTTGTATTATAAAGAACTCTA CCACACTAGCTCTTCTGAAATTTTATCAGGGGCTGTGACACTTGGACCTACTGTCTTTTGAGTTATAT AGTTCTCCTAGACTCAAAATGTTAGGGCAAAAAGTGTTCTTAACACTGAGTTGGGCTCAATGGCTCAC GCCTAAATCCCAGCACTTTGGGAGGCTAAAGTGGGAGGATCACTTGAAGCCAGGAGTTCCAGACCA GCCTGGCCAAAAAAAAAATTTAATTAGCTGGGCATGGTGTCACGCACCTGTGATCCCAGCTGAGGTC GGGGGAGACTGCTTGAGCCTGGGAGGTCAAGGCTGCAGTGAGCTGTGATTGCACCACTGCACTGC AGCCTGGGCGGCAGAGCAAGACCCTGTTTCAGAGAAAAAAAAAAACTGGTCCAACTCCTCTCCTATC AGTTGCTGAATATGCAGCCCCAAAGGATATGACTCGCTAGGCTTATGTAGCCAGGACCCAAGATCTG TAACATGCATTTTACATAGGTATATATTACAGATATATAATTTTGTCACGATGGCTGTAACGAGATTTG GATAGAAATGGGTATTGACTCCATGACAGTGAGTTCATAGCCAGAAATGGTTGTTGTGTTAGGCATG

[1321] CTCCACTTGTCCCTACTGTTGTCATCACCAATCTGGGAAGACACTGCTAGTGTAAACAAAAGGCACC

[1322] TGCTGAGGCAGGTCCACACGCCACCTCAGGGAGCTCCCATTTCCCTGACACTGCACGTTGGTGTTT

[1323] CCCACCATTGCTCCTGGTGAAATGGTTGCAGCAGGCGACAGGGTCAACCTCTTCTATAAAATAGTTC

[1324] TAGGGGCAATTGGAACCAAGATGACTTCTGTATCTTCCTATAACATGCATATAACAGCTGTTCTTCTG

[1325] CAACACCTCTCATCTCAAACTTTATTAGACAACTAATTGTGGTATTTACATTAAGGTTCCCTAGGAAAC

[1326] TAACAAAGTTACAAACGTGTGTGCTAAAATTTAACACTGGACCTCTGTTGCCATTTGAGGCCATACCC

[1327] TAAAACTTAACTTTGAATGTACTTGTAGCTGCTCATCAGGAAGAGAGGAACAGATACTGTAAATGTGT

[1328] TTTTTTGCTTTGGCATATTTTTGACGGGAGGGGTGGCACTGCGTCTGCTGGAATATGTTTACAATCTG

[1329] GTCTATCTGGAAGTTTTTCTATAAAAATCAAACTGGGATCCCAGGGTCACTACACTTAGCTTAGGTCC

[1330] AATGGTCTAGAAATAACAACTGATTCAATTTAGAGAGTATTTCATTCAGGCCAGGCCTAGTTCTAAGA

[1331] GCTTTACCTAACTAACTCATTTAACCTTTTTAATCCATTCTACAAATTAGGACATTAAGGTACAGATCA

[1332] AAGTTATTTGCCCAAACTCATAGCAAGCAAATGGTAGAGCTCCTAGTCAGATCCAGCAAGTCTGACT

[1333] CCAACAGCCTGAGTTCTGGAAGCATTACACCAGCTTTTCAAATGTCAGATTGAGACAACTTAGTAGG

[1334] CTGTAAAATCAGTTTAGGAGGTCTCAACTGGCCATTCTTCTTTAGTATGTAGAATAAAATGAAAATAGT

[1335] GTGCATCATGGTAAATACTGTTTTGTGAACTTTTGGTTTGATATATGTGTACACAAGTATATTTATATG

[1336] CTAGGTAATATGAAATTCTTAAACTGTGATCAAAAAGGCTGACACCAAGCTGTGTTGACTCAGATCAT

[1337] CTGACTCCGCCTAGAACAAGACAGCAGGATCTGAATCTCAGGTATGAGCTTGGCAAAGCACCTAACC

[1338] CATCTATAGCTCAACTTCTTCACCTATAAAGTGGAAATAATAATGTGAAGATTTGATAAATTTACACAT

[1339] TAAGTGCTAACAACAGTGCCTGGCCCATAGTAAGTTTTCATTATTATTTCCTGTAACTATATATTGCCA

[1340] TCATCAATCAAATGTTGTACTTAAAATCCTTTTGGGACTCCTCCCACGTTAAGTATTTTCCCATATGCT

[1341] ATACAGCGGGTGGAGGTCCATTCCTTTGAGAAGGCTTGGAACAATTCCCTCCATGGCCCACATGTG

[1342] GAAAAGAGGATTCCAATATGGCCTCCTTATTCTTTAAACAAAAGAATGCTCTTTTTAAAGTTATCTTTT

[1343] AAATCAAGCAACTGATTTCTAAGGAATGGGGCTAATGAGATTATCCTGAGTTCACTGTTGTAGATTGT

[1344] ATTCTTTCCAAAAAAACTTTTATTGATATTGGGGAGTGGGCGGTCATGAGGGATGGGGTGGGGGTGA

[1345] GTGGAAGACAAGGAAAAATGAAACCTAAAAAGTACAAAGAGATCTGATGGTTTTAAAAGTAAAGACCT

[1346] TAAACATCACTTCATCAGCTCAGGCAGCTCACACACAGGTGAGTAAACACAAAACCGGAGAAGTGTC

[1347] CCCAGCACCCCTTGCAAGAGGGACAGGACTGCTGAAGCTGTCAGCAGGGGAGGGTGCAACTGTTC

[1348] CACTTGCTTCAGCTTTTCCTGCCATGGTGCCTGCTCTGTGACATCCAAAGAGAACCAAAGTGGGACT

[1349] GGAAACCCAGTTACTAGGAAAGCCTATCATACCATACCCCAGCTTAAAGCCTGCCAGAGGCTGCTCG

[1350] CTGCATTCAACCCAGAATCTAAACCTGTGGCCCTGGTCTGCTTATGAGATCTAGTCCCACCCTCTCC

[1351] TCACCAGTGGGAGATGCCCTGGACTTTCTGTTCCTTAAACACGGGAGTGACTGTGGTCCCATGCGA

[1352] GACCTTGATTCCTGCTGTTCCTTACTCCCAGAACACTCTTCACCCTCGCACAACTGGCTCCTCCTACT

[1353] TGTTCCGCTTTCAGCTCAAATGCCCTCCCTGACCAGTCAAAAGTTCAATTTGCTTTTCTCGCCCATCT

[1354] CTAGCACCTCACCCAGTGCCATTTCCTCCACAGCACTTAGTAAATCTCACTTGGTTAGTGACTGTCTA

[1355] CCCTTTCTAATAAGTTCTCTGAGAACAGAACCTTATCTTCTTTAGTACCAGATTCTCAACGCCTGAGT

[1356] GATCAAAAACCTAAGTAGAAAAAAAGGGAGTCCACGCACGGTGGCTCACACCTGTAATCTCAGCACT

[1357] TTGGGAAGCCAAGGCAGGAAGATCACTTGAGGCCTCGACTTCAAGACCAGCTTGGGCAACACAGAC

[1358] TCTCTGTCAACACACACACACATTAGCCAAGTGTGGTGGCACACACTTGTAGTCCCAGCTACTGGGG

[1359] The corresponding BRAF protein encoded by the wild-type BRAF gene is identified by UniProt ID P15056 (https: / / www.uniprot.org / uniprotkb / P15056 / entry). The amino acid sequence of the wild-type BRAF protein is SEQ ID NO: 2: The inventors have observed that mutations in BRAF in colorectal cancer cell lines sensitises the cancer cells to the combination of a BRAF inhibitor and an ALK / TRK inhibitor as compared to BRAF wild-type colorectal cancer cells. That is, the colorectal cancer is preferably a BRAF mutant colorectal cancer. The inventors observed that the preferred BRAF mutation is V600 including V600E, V600K, V600D, V600R, and V600M. The most prevalent BRAF mutation is V600E. Accordingly, in some cases, the BRAF mutation in the BRAF mutant colorectal cancer is a BRAF7600mutation. In some cases, the BRAF mutation in the BRAF mutant colorectal cancer is selected from the group consisting of a BRAFJW0Emutation, a BRA F7600Kmutation, a BRAF76000mutation, a BRA F7600Rmutation, and a BRAF760™ mutation. In some cases, the BRAF mutation in the BRAF mutant colorectal cancer is a BRA F7600Emutation.

[1360] Preferably, the BRAF mutant colorectal cancer is a cancer driver mutation. A cancer driver mutation is a mutation that provides a selective growth advantage, and thus promotes cancer development. Cancer driver mutations can be: (i) proto-oncogenes, which requires a gain-of-function mutation to become tumorigenic; or (ii) tumour suppressor genes, which require inactivation of both alleles to become tumorigenic.

[1361] The cancer driver mutations may overlap the genomic coordinates of a mutation with the same effect in the library of mutations. For example, the mutation may be: missense (a mutation that changes the coded amino acid), nonsense (a mutation that causes a shift in the reading frame or the formation of a premature stop codon which forms a truncated protein upon translation), inframe (a mutation occurring within the protein-coding region of a gene which results in a retention of the reading frame such that the protein production machinery can continue to read the DNA sequence after the mutation), or silent (a mutation that has no effect on the coded amino acid sequence). Alternatively, the cancer driver mutation may be in a LoF (loss-of-fu notion) or an ambiguous gene (that is, a gene with evidence of both activating and loss-of-function events), and the mutation has a loss of function effect. For example, the mutation may be: frameshift (an insertion or deletion of nucleotide bases in numbers that are not multiples of three), nonsense (a mutation that causes a protein to terminate or end its translation earlier than expected), ess_splice (exonic splicing silencer), start ost (a mutation that affects the initiation codon), or stopjost (a mutation that affects the final codon). The skilled person would understand that the cancer driver mutation does not need to result in the total loss of the production of the coded protein, such as the BRAF protein. The skilled person would also understand the cancer driver mutation can instead result in an overexpression and / or increased activity of the production of the coded protein, such as the BRAF protein.

[1362] Accordingly, in some embodiments, the BRAF mutation in the BRAF mutant colorectal cancer is a cancer driver mutation. In some embodiments, the BRAF mutation in the BRAF mutant colorectal cancer comprises a nonsense, frameshift, or truncating mutation. In some embodiments, the BRAF mutation in the BRAF mutant colorectal cancer results in increased activity of BRAF protein. For example, in some embodiments, the BRAF mutation in the BRAF mutant colorectal cancer results in increased kinase activity of BRAF, constitutive activation of BRAF, and / or insensitivity to negative feedback. In some embodiments, the method of treatment comprises a step of determining the patient’s BRAF mutational status.

[1363] Unbiased analysis of mutant and wild-type reads found at the loci of the base substitutions and indels (insertions / deletions) are assessed across the related samples using “vafCorrect” (https: / / github.com / cancerit / vafCorrect; see also Yates et al., Cancer Cell, 2017, 32(2), p169-184), which assigns a VAF (Variant Allele Frequency) to each sample within each variant. Only VCF (Variant Call Format) records with PASS in the FILTER column and with a VAF >= 0.15 were considered for flagging as drivers.

[1364] The inventors used CellModelPassports (https: / / cellmodelpassports.sanger.ac.uk / ; see also Van der Meer etal., Nucleic Acids Research, 2019, Volume 47, Issue D1 , pD923-D929) to identify and determine the mutation status of cancer cell lines. CellModelPassports uses the OncodriveFML methodology (Mularoni etal., Genome Biol, 2016, 17, 128, https: / / doi.org / 10.1186 / s13059-016-0994-0) to identify the mutational status of various cancer cell lines described in the database. The skilled person would appreciate that the OncodriveFML methodology can be used to identify the mutational status of other cancer cell lines, such as identifying the BRAF mutational status of such cancer cell lines.

[1365] For a patient to be eligible for treatment with a combination of a BRAF inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof) and an ALK / TRK inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof), a patient would first need to receive a clinical diagnosis of colorectal cancer. A patient would also need to undergo diagnostic testing to determine the mutational status of BRAF in a suitable tumour sample, which may include a tissue biopsy, liquid biopsy or other suitable biological sample. The mutational status of BRAF may be confirmed via any approved companion diagnostic test that is able to analyse variations in the sequence, structure, or expression of human nucleic acids. Examples of such nucleic-acid-based tests include but are not limited to: Foundation Medicine’s FoundationOne® CDx and FoundationOneOLiquid CDx, Guardant Health’s Guardant360® TissueNext and Guardant360® CDx, and Illumina’s TruSight Oncology Comprehensive.

[1366] Accordingly, provided herein is a method of selecting a subject having or determined to have BRAF mutant colorectal cancer for treatment with a combination of a BRAF inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof) and an ALK / TRK inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof), the method comprising determining the mutational status of BRAF gene in the colorectal cancer and selecting the subject for treatment if the BRAF gene is a BRAF mutant. In some embodiments, the method comprises the step of selecting a subject having or determined to have BRAF mutant colorectal cancer for treatment with a BRAF inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof), the method comprising determining the mutational status of BRAF gene in the colorectal cancer and selecting the subject for treatment if the BRAF gene is a BRAF mutant, wherein the BRAF inhibitor is administered to the subject in combination with an ALK / TRK inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof). In some embodiments, the method comprises the step of selecting a subject having or determined to have BRAF mutant colorectal cancer for treatment with an ALK / TRK inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof), the method comprising determining the mutational status of BRAF gene in the colorectal cancer and selecting the subject for treatment if the BRAF gene is a BRAF mutant, wherein the ALK / TRK inhibitor is administered to the subject in combination with a BRAF inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof).

[1367] Also provided herein is a method of predicting whether a subject having colorectal cancer is likely to respond to treatment with a combination of a BRAF inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof) and an ALK / TRK inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof), the method comprising determining the mutational status of BRAF gene in the colorectal cancer and selecting the subject for treatment if the BRAF gene is a BRAF mutant. Provided herein is a method of predicting whether a subject having colorectal cancer is likely to respond to treatment with a BRAF inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof), the method comprising the step of determining the mutational status of BRAF gene in the colorectal cancer and selecting the subject for treatment if the BRAF gene is a BRAF mutant, wherein the BRAF inhibitor is administered to the subject in combination with an ALK / TRK inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof). Provided herein is a method of predicting whether a subject having colorectal cancer is likely to respond to treatment with an ALK / TRK inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof), the method comprising determining the mutational status of BRAF gene in the colorectal cancer and selecting the subject for treatment if the BRAF gene is a BRAF mutant, wherein the ALK / TRK inhibitor is administered to the subject in combination with a BRAF inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof).

[1368] Also described herein is a method for identifying a subject with BRAF mutant colorectal cancer who is likely to respond to treatment with a combination of a BRAF inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof) and an ALK / TRK inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof), the method comprising obtaining a biopsy sample from the subject and determining the mutational status of BRAF gene in the colorectal cancer in said biopsy sample, wherein the subject is likely to respond to treatment with a combination of a BRAF inhibitor and an ALK / TRK inhibitor if the BRAF gene is a BRAF mutant. Also described herein is a method for identifying a subject with BRAF mutant colorectal cancer who is likely to respond to treatment with a BRAF inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof), the method comprising obtaining a biopsy sample from the subject and determining the mutational status of BRAF gene in the colorectal cancer in said biopsy sample, wherein the subject is likely to respond to treatment with the BRAF inhibitor, wherein the BRAF inhibitor is administered to the subject in combination with an ALK / TRK inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof). Also described herein is a method for identifying a subject with BRAF mutant colorectal cancer who is likely to respond to treatment an ALK / TRK inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof), the method comprising obtaining a biopsy sample from the subject and determining the mutational status of BRAF gene in the colorectal cancer in said biopsy sample, wherein the subject is likely to respond to treatment with the ALK / TRK inhibitor, wherein the ALK / TRK inhibitor is administered to the subject in combination with a BRAF inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof). Also provided herein is a method of treating or preventing colorectal cancer in a subject in whom the colorectal cancer is BRAF mutant colorectal cancer, wherein the method comprises administering a combination of a BRAF inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof) and an ALK / TRK inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof) to the subject. Also provided herein is a method of treating or preventing colorectal cancer in a subject in whom the colorectal cancer is BRAF mutant colorectal cancer, wherein the method comprises administering a BRAF inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof) to the subject, wherein the BRAF inhibitor is administered to the subject in combination with an ALK / TRK inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof). Also provided herein is a method of treating or preventing colorectal cancer in a subject in whom the colorectal cancer is BRAF mutant colorectal cancer, wherein the method comprises administering an ALK / TRK inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof) to the subject, wherein the ALK / TRK inhibitor is administered to the subject in combination with a BRAF inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof).

[1369] Also provided herein is a method of treating or preventing BRAF mutant colorectal cancer in a subject, wherein the method comprises: determining the mutational status of BRAF gene in the colorectal cancer and administering a combination of a BRAF inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof) and an ALK / TRK inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof) to a subject having or determined to have BRAF mutant colorectal cancer. Also provided herein is a method of treating or preventing BRAF mutant colorectal cancer in a subject, wherein the method comprises: determining the mutational status of BRAF gene in the colorectal cancer and administering a BRAF inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof) to a subject having or determined to have BRAF mutant colorectal cancer, wherein the BRAF inhibitor is administered to the subject in combination with an ALK / TRK inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof). Also provided herein is a method of treating or preventing BRAF mutant colorectal cancer in a subject, wherein the method comprises: determining the mutational status of BRAF gene in the colorectal cancer and administering an ALK / TRK inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof) to a subject having or determined to have BRAF mutant colorectal cancer, wherein the ALK / TRK inhibitor is administered to the subject in combination with a BRAF inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof).

[1370] Also provided herein is a method of treating or preventing colorectal cancer in a subject, the method comprising administering a combination of a BRAF inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof) and an ALK / TRK inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof) to the subject, wherein the subject has been selected for treatment with a combination of a BRAF inhibitor and an ALK / TRK inhibitor on the basis of whether the colorectal cancer is BRAF mutant colorectal cancer. Also provided herein is a method of treating or preventing colorectal cancer in a subject, the method comprising administering a BRAF inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof) to the subject, wherein the subject has been selected for treatment with a BRAF inhibitor on the basis of whether the colorectal cancer is BRAF mutant colorectal cancer, wherein the BRAF inhibitor is administered to the subject in combination with an ALK / TRK inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof). Provided herein is a method of treating or preventing colorectal cancer in a subject, the method comprising administering an ALK / TRK inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof) to the subject, wherein the subject has been selected for treatment with an ALK / TRK inhibitor on the basis of whether the colorectal cancer is BRAF mutant colorectal cancer, wherein the ALK / TRK inhibitor is administered to the subject in combination with a BRAF inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof).

[1371] Also described herein is a method of identifying and treating a subject suitable for treatment of BRAF mutant colorectal cancer, the method comprising: a) obtaining a biopsy sample from the subject; b) determining the mutational status of BRAF gene in the colorectal cancer in said biopsy sample; c) identifying the subject as being suitable for treatment of BRAF mutant colorectal cancer when the BRAF gene is a BRAF mutant; and d) administering an effective amount of a combination of a BRAF inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof) and an ALK / TRK inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof) to the subject.

[1372] Also described herein is a method of identifying and treating a subject suitable for treatment of BRAF mutant colorectal cancer, the method comprising: a) obtaining a biopsy sample from the subject; b) determining the mutational status of BRAF gene in the colorectal cancer in said biopsy sample; c) identifying the subject as being suitable for treatment of BRAF mutant colorectal cancer when the BRAF gene is a BRAF mutant; and d) administering an effective amount of a BRAF inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof) to the subject, wherein the BRAF inhibitor is administered to the subject in combination with an ALK / TRK inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof).

[1373] Also described herein is a method of identifying and treating a subject suitable for treatment of BRAF mutant colorectal cancer, the method comprising: a) obtaining a biopsy sample from the subject; b) determining the mutational status of BRAF gene in the colorectal cancer in said biopsy sample; c) identifying the subject as being suitable for treatment of BRAF mutant colorectal cancer when the BRAF gene is a BRAF mutant; and d) administering an effective amount of an ALK / TRK inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof) to the subject, wherein the ALK / TRK inhibitor is administered to the subject in combination with a BRAF inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof).

[1374] Also described herein is a combination of a BRAF inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof) and an ALK / TRK inhibitor (or a pharmaceutically acceptable salt, hydrate, or solvate thereof) for use in a method of treating or preventing colorectal cancer i...

Claims

Claims1 . A combination of a BRAF inhibitor or a pharmaceutically acceptable salt, hydrate, or solvate thereof, and an ALK / TRK inhibitor or a pharmaceutically acceptable salt, hydrate, or solvate thereof, for use in a method of treatment of colorectal cancer in a patient.

2. A BRAF inhibitor or a pharmaceutically acceptable salt, hydrate, or solvate thereof, for use in a method of treatment of colorectal cancer in a patient, wherein the BRAF inhibitor is administered to a patient in combination with an ALK / TRK inhibitor or a pharmaceutically acceptable salt, hydrate, or solvate thereof.

3. An ALK / TRK inhibitor or a pharmaceutically acceptable salt, hydrate, or solvate thereof, for use in a method of treatment of colorectal cancer in a patient, wherein the ALK / TRK inhibitor is administered to a patient in combination with an BRAF inhibitor or a pharmaceutically acceptable salt, hydrate, or solvate thereof.

4. A method of treatment of colorectal cancer, wherein the method comprises administering a therapeutically effective amount of a combination of a BRAF inhibitor or a pharmaceutically acceptable salt, hydrate, or solvate thereof, and an ALK / TRK inhibitor or a pharmaceutically acceptable salt, hydrate, or solvate thereof, to a patient in need thereof.

5. A method of treatment of colorectal cancer, wherein the method comprises administering a therapeutically effective amount of a BRAF inhibitor or a pharmaceutically acceptable salt, hydrate, or solvate thereof, to a patient in need thereof, wherein the BRAF inhibitor is administered to the patient in combination with an ALK / TRK inhibitor or a pharmaceutically acceptable salt, hydrate, or solvate thereof.

6. A method of treatment of colorectal cancer, wherein the method comprises administering a therapeutically effective amount of an ALK / TRK inhibitor or a pharmaceutically acceptable salt, hydrate, or solvate thereof, to a patient in need thereof, wherein the ALK / TRK inhibitor is administered to the patient in combination with a BRAF inhibitor or a pharmaceutically acceptable salt, hydrate, or solvate thereof.

7. A method of predicting whether a subject having colorectal cancer is likely to respond to treatment with a combination of a BRAF inhibitor or a pharmaceutically acceptable salt, hydrate, or solvate thereof, and an ALK / TRK inhibitor or a pharmaceutically acceptable salt, hydrate, or solvate thereof, the method comprising determining the mutational status of BRAF gene in the colorectal cancer and selecting the subject for treatment if the BRAF gene is a BRAF mutant.

8. A method of predicting whether a subject having colorectal cancer is likely to respond to treatment with a BRAF inhibitor or a pharmaceutically acceptable salt, hydrate, or solvate thereof, the method comprising the step of determining the mutational status of BRAF gene in the colorectal cancer and selecting the subject for treatment if the BRAF gene is a BRAF mutant, wherein the BRAF inhibitor isadministered to the subject in combination with an ALK / TRK inhibitor or a pharmaceutically acceptable salt, hydrate, or solvate thereof.

9. A method of predicting whether a subject having colorectal cancer is likely to respond to treatment with an ALK / TRK inhibitor or a pharmaceutically acceptable salt, hydrate, or solvate thereof, the method comprising determining the mutational status of BRAF gene in the colorectal cancer and selecting the subject for treatment if the BRAF gene is a BRAF mutant, wherein the ALK / TRK inhibitor is administered to the subject in combination with a BRAF inhibitor or a pharmaceutically acceptable salt, hydrate, or solvate thereof.

10. The combination for use according to claim 1 , the BRAF inhibitor for use according to claim 2, the ALK / TRK inhibitor for use according to claim 3, or the method according to any one of claims 4-9, wherein the colorectal cancer is BRAF mutant colorectal cancer.11 . The combination, the BRAF inhibitor, or the ALK / TRK inhibitor for use, or the method according to claim 10, wherein the BRAF mutation in the BRAF mutant colorectal cancer is a cancer driver mutation.

12. The combination, the BRAF inhibitor, or the ALK / TRK inhibitor for use, or the method according to claim 10 or 11 , wherein the BRAF mutation in the BRAF mutant colorectal cancer is a BRAF7600mutation, optionally wherein the BRAF mutation is selected from the group consisting of a BRAF'W0Emutation, a BRA F7600Kmutation, a BRAF76000mutation, a BRA F7600Rmutation, and a BRAF760™ mutation.

13. The combination, the BRAF inhibitor, or the ALK / TRK inhibitor for use, or the method according to any one of claims 10 to 12, wherein the BRAF mutation is selected from the group consisting of a BRA F7600Emutation, a BRA F7600Kmutation, a BRAF76000mutation, a BRAF'7600Rmutation, and a BRAF760071mutation.

14. The combination, the BRAF inhibitor, or the ALK / TRK inhibitor for use, or the method according to any one of claims 10 to 13, wherein the BRAF mutation in the BRAF mutant colorectal cancer is a BRA F7600Emutation.

15. The combination, the BRAF inhibitor, or the ALK / TRK inhibitor for use, or the method according to any one of claims 10 to 14, wherein the BRAF mutation in the BRAF mutant colorectal cancer results in increased activity of BRAF protein, optionally wherein the BRAF mutation in the BRAF mutant colorectal cancer results in increased kinase activity of BRAF, constitutive activation of BRAF, and / or insensitivity to negative feedback.

16. The combination, the BRAF inhibitor, or the ALK / TRK inhibitor for use, or the method according to any one of claims 10 to 15, wherein the method of treatment comprises a step of determining the patient’s BRAF mutational status.

17. The combination, the BRAF inhibitor, or the ALK / TRK inhibitor for use, or the method according to any one of the preceding claims, wherein the BRAF inhibitor is selected from the group consisting ofvemurafenib, dabrafenib, regorafenib, sorafenib, encorafenib, CFT-1946, tinlorafenib, ARQ-736, RAF- 265, BAL-3833, and XL-281.

18. The combination, the BRAF inhibitor, or the ALK / TRK inhibitor for use, or the method according to claim 17, wherein the BRAF inhibitor is selected from the group consisting of vemurafenib, dabrafenib, regorafenib, encorafenib, tinlorafenib, and XL-281.

19. The combination, the BRAF inhibitor, or the ALK / TRK inhibitor for use, or the method according to claim 17 or 18, wherein the BRAF inhibitor is selected from the group consisting of vemurafenib and dabrafenib.

20. The combination, the BRAF inhibitor, or the ALK / TRK inhibitor for use, or the method according to any one of the preceding claims, wherein the ALK / TRK inhibitor is selected from the group consisting of ASP-3026, belizatinib, CEP-37440, TPX-0131 , alectinib, ceritinib, crizotinib, entrectinib, foretinib, merestinib, GW441756, unecritinib, CT-3505, conteltinib, and envonalkib.21 . The combination, the BRAF inhibitor, or the ALK / TRK inhibitor for use, or the method according to claim 20, wherein the ALK / TRK inhibitor is selected from the group consisting of belizatinib, crizotinib, entrectinib, TPX-0131 , envonalkib, unecritinib, and CT-3505.

22. The combination, the BRAF inhibitor, or the ALK / TRK inhibitor for use, or the method according to claim 20 or 21 , wherein the ALK / TRK inhibitor is selected from the group consisting of belizatinib, crizotinib, entrectinib, TPX-0131 , envonalkib, and unecritinib.

23. The combination, the BRAF inhibitor, or the ALK / TRK inhibitor for use, or the method according to any one of the preceding claims, wherein the combination of a BRAF inhibitor and an ALK / TRK inhibitor is selected from: vemurafenib and belizatinib; vemurafenib and alectinib; vemurafenib and ceritinib; vemurafenib and crizotinib; vemurafenib and entrectinib; vemurafenib and ASP-3026; vemurafenib and CEP-37440; vemurafenib and TPX-0131 ; vemurafenib and conteltinib; vemurafenib and envonalkib; vemurafenib and merestinib; vemurafenib and foretinib; vemurafenib and GW441756; dabrafenib and belizatinib; sorafenib and belizatinib; RAF-265 and belizatinib; CFT-1946 and entrectinib; vemurafenib and unecritinib; and BAL-3833 and entrectinib.

24. The combination, the BRAF inhibitor, or the ALK / TRK inhibitor for use, or the method according to any one of the preceding claims, wherein the combination of a BRAF inhibitor and an ALK / TRK inhibitor is selected from: vemurafenib and belizatinib; vemurafenib and entrectinib; vemurafenib and crizotinib; vemurafenib and envonalkib; vemurafenib and TPX-0131 ; vemurafenib and unecritinib; and dabrafenib and belizatinib.

25. The combination, the BRAF inhibitor, or the ALK / TRK inhibitor for use, or the method according to any one of the preceding claims, wherein the BRAF inhibitor and the ALK / TRK inhibitor are administered separately.

Images