Real-time early stage delirium detection and management

The M1 index addresses the inaccuracy of existing EEG-guided anesthetic management systems by providing precise EEG-based monitoring for older patients and ADRD patients, reducing POD risk by 50% through personalized anesthetic management.

WO2025255407A1PCT designated stage Publication Date: 2025-12-11PASCALL SYSTEMS INC
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Patent Information

Application Number
PCT/US2025/032548
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2025-06-05
Filing Date
2025-06-05
Publication Date
2025-12-11

AI Technical Summary

Technical Problem

Existing EEG-guided anesthetic management systems, such as the Bispectral Index (BIS) and Sedline, are inaccurate for older patients and those with Alzheimer's Disease and Related Dementias (ADRD), leading to increased risk and incidence of post-operative delirium (POD), and fail to account for individual patient variability in anesthetic needs.

Method used

A computerized framework utilizing the M1 index for EEG-based monitoring that accurately assesses anesthetic brain state and provides real-time guidance for personalized anesthetic management, reducing the risk of POD by 50% or more.

Benefits of technology

The M1 index achieves 100% accuracy in identifying patients at risk of POD, allowing for precise titration of anesthesia to minimize anesthetic exposure and significantly reduce POD incidence compared to conventional systems.

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Abstract

Disclosed are systems and methods that provide a novel computerized framework for a closed-loop, decision-intelligence (DI)-based computerized framework for automatically and dynamically managing and controlling a medical procedure, inclusive of administered medication and / or anesthesia to a patient and an intraoperative level of consciousness of the patient. The disclosed framework provides an improved electroencephalography (EEG) indices that adapts to specific patient needs, and dynamically adapts to factors of an ongoing procedure to ensure that the proper levels of anesthesia are administered, required and / or maintained. This provides computerized capabilities to maintain safe levels of the patient's consciousness, such that post-operative patient health is preserved and maintained. Thus, the disclosed framework provides an effective anesthesia management framework that can be leveraged to safely manage a patient's health during and after a medical procedure for which anesthesia is used.
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Citation Information

Patent Citations

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