Stabilized gum formulations and methods

Abstract

Stabilized compositions, such as those improving viscosity stability in a composition, include karaya gum and caprylhydroxamic acid. Methods of improving viscosity stability in a composition including karaya gum include introducing caprylhydroxamic acid to the composition to produce a stabilized composition. Methods of using a stabilized composition including karaya gum and caprylhydroxamic acid include exposing the stabilized composition to an elevated temperature for a predetermined temperature length of time, wherein viscosity of the stabilized composition after the predetermined temperature length of time is at least 75%, at least 80%, at least 85%, at least 90%, or at least 95% of original viscosity. Other methods of using the stabilized composition include exposing the stabilized composition to UV irradiation at 60 W / m2 with wavelength between 300 nm and 400 nm for a predetermined light length of time.

Description

STABILIZED GUM FORMULATIONS AND METHODSCROSS-REFERENCE TO RELATED APPLICATION

[0001] This application relates to, incorporates by reference for all purposes, and claims priority to United States Application Serial Number 63 / 679,730, filed August 6, 2024 and entitled STABILIZED GUM FORMULATIONS AND METHODS.BACKGROUND

[0002] Karaya gum is known to undergo a permanent loss of viscosity after exposure to elevated temperatures for extended periods of time. Without wishing to be bound by any particular theory, the mechanism by which karaya gum loses viscosity over time at elevated temperatures is not particularly well understood, so the solution is obscured by the lack of knowledge regarding the cause. Similar effects may be observable in other bassorin-containing gums, such as Astragalus gummifer gum. It should be appreciated that finding a solution to a problem where the underlying mechanism is not well understood is a more difficult scientific endeavor and a skilled artisan would consider it to be more inventive (or less obvious) as a result.

[0003] A need exists for compositions and methods having improved stability in general, and more particularly improved stability with respect to exposure to UV light and / or elevated temperatures.SUMMARY

[0004] Disclosed herein is a stabilized composition including: karaya gum and caprylhydroxamic acid.

[0005] Disclosed herein is an example method of improving viscosity stability in a composition including karaya gum, the method including introducing caprylhydroxamic acid to the composition to produce a stabilized composition.

[0006] Disclosed herein is an example method of using a stabilized composition, the stabilized composition including karaya gum and caprylhydroxamic acid, the method including: exposing the stabilized composition to an elevated temperature for a predetermined temperature length of time, wherein the elevated temperature is 45 °C, wherein the predetermined temperature length of time is at least 5 days, at least 10 days, at least 15 days, at least 20 days, atleast 25 days, at least 30 days, at least 35 days, at least 40 days, at least 45 days, at least 50 days, at least 60 days, at least 70 days, at least 75 days, or more, wherein viscosity of the stabilized composition after the predetermined temperature length of time is at least 75%, at least 80%, at least 85%, at least 90%, or at least 95% of original viscosity.

[0007] Disclosed herein is an example method of using a stabilized composition, the stabilized composition including karaya gum and caprylhydroxamic acid, the method including: exposing the stabilized composition to UV irradiation at 60 W / m with wavelength between 300 nm and 400 nm for a predetermined light length of time, wherein the predetermined light length of time is at least 6 hours, at least 12 hours, or more, wherein viscosity of the stabilized composition after the predetermined light length of time is at least 75%, at least 80%, at least 85%, at least 90%, or at least 95% of original viscosity.

[0008] Disclosed herein is a stabilized composition including a bassorin-containing gum and caprylhydroxamic acid.

[0009] Disclosed herein is an example method of improving viscosity stability in a composition including a bassorin-containing gum, the method including: introducing caprylhydroxamic acid to the composition to produce a stabilized composition.

[0010] Disclosed herein is an example method of using a stabilized composition, the stabilized composition including bassorin-containing gum and caprylhydroxamic acid, the method including: exposing the stabilized composition to an elevated temperature for a predetermined temperature length of time, wherein viscosity of the stabilized composition after the predetermined temperature length of time is at least 75%, at least 80%, at least 85%, at least 90%, or at least 95% of original viscosity.

[0011] Disclosed herein is an example method of using a stabilized composition, the stabilized composition including bassorin-containing gum and caprylhydroxamic acid, the method including: exposing the stabilized composition to UV irradiation at 60 W / m with wavelength between 300 nm and 400 nm for a predetermined light length of time, wherein viscosity of the stabilized composition after the predetermined light length of time is at least 75%, at least 80%, at least 85%, at least 90%, or at least 95% of original viscosity.

[0012] Disclosed herein is a stabilized composition including Astragalus gummifer gum, and caprylhydroxamic acid.

[0013] Disclosed herein is an example method of improving viscosity stability in a composition including Astragalus gummifer gum, the method including: introducing caprylhydroxamic acid to the composition to produce a stabilized composition.

[0014] Disclosed herein is an example method of using a stabilized composition, the stabilized composition including Astragalus gummifer gum and caprylhydroxamic acid, the method including: exposing the stabilized composition to an elevated temperature for a predetermined temperature length of time, wherein viscosity of the stabilized composition after the predetermined temperature length of time is at least 75%, at least 80%, at least 85%, at least 90%, or at least 95% of original viscosity.

[0015] Disclosed herein is an example method of using a stabilized composition, the stabilized composition including Astragalus gummifer gum and caprylhydroxamic acid, the method including: exposing the stabilized composition to UV irradiation at 60 W / m with wavelength between 300 nm and 400 nm for a predetermined light length of time, wherein viscosity of the stabilized composition after the predetermined light length of time is at least 75%, at least 80%, at least 85%, at least 90%, or at least 95% of original viscosity.

[0016] Disclosed herein is a dry particulate composition including powdered karaya gum and powdered caprylhydroxamic acid, wherein a ratio by weight of the karaya gum to the caprylhydroxamic acid is at least 9:1 and at most 24:1.

[0017] These and other systems, methods, objects, features, and advantages of the present disclosure will be apparent to those skilled in the art from the following detailed description of the preferred embodiment and the drawings.

[0018] All documents mentioned herein are hereby incorporated in their entirety by reference. References to items in the singular should be understood to include items in the plural, and vice versa, unless explicitly stated otherwise or clear from the text. Grammatical conjunctions are intended to express any and all disjunctive and conjunctive combinations of conjoined clauses, sentences, words, and the like, unless otherwise stated or clear from the context.BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Non-limiting embodiments of the present invention will be described by way of example with reference to the accompanying figures, which are schematic and are not intended to be drawn to scale. In the figures, each identical or nearly identical component illustrated istypically represented by a single numeral. For purposes of clarity, not every component is labeled in every figure, nor is every component of each embodiment of the invention shown where illustration is not necessary to allow those of ordinary skill in the art to understand the invention.

[0020] Fig. 1 is a plot showing viscosity versus time stored at elevated temperature for inventive and comparative compositions, as described in Example 1.

[0021] Fig. 2 is a plot showing viscosity versus time stored at elevated temperature for inventive and comparative compositions, as described in Example 1.

[0022] Fig. 3 is a plot showing viscosity versus time exposed to UV light for inventive and comparative compositions, as described in Example 2.DETAILED DESCRIPTION

[0023] Before the present disclosure is described in further detail, it is to be understood that the disclosure is not limited to the embodiments described. It is also understood that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting. As used herein, the singular forms "a", "an", and "the" include plural embodiments unless the context clearly dictates otherwise.

[0024] It should be apparent to those skilled in the art that many additional modifications beside those already described are possible without departing from the inventive concepts. In interpreting this disclosure, all terms should be interpreted in the broadest possible manner consistent with the context. Variations of the term "comprising" or "including" should be interpreted as referring to elements, components, or steps in a non-exclusive manner, so the referenced elements, components, or steps may be combined with other elements, components, or steps that are not expressly referenced. When two or more ranges for a particular value are recited, this disclosure contemplates all combinations of the upper and lower bounds of those ranges that are not explicitly recited. For example, recitation of a value of between 1 and 10 or between 2 and 9 also contemplates a value of between 1 and 9 or between 2 and 10. All ranges are inclusive of the upper and lower value.

[0025] As used herein, “karaya gum” refers to a vegetable gum exuded by trees from the genus Sterculia. Karaya gum is referred to by other names, including gum sterculia or Indian gum tragacanth.

[0026] Astragalus gummifer (tragacanth, gum tragacanth milkvetch), is a small woody evergreen shrub, with a typical height and spread of 30 cm at maturity, indigenous to western Asia, specifically Iran, Iraq and Turkey.

[0027] Bassorin is a substance that is a constituent of some gums (as tragacanth) and is insoluble in water but swells to form a gel.

[0028] The present disclosure provides a stabilized composition comprising: karaya gum and / or a bassorin-containing gum and / or Astragalus gummifer gum; and caprylhydroxamic acid. The present disclosure provides a stabilized composition comprising karaya gum and caprylhydroxamic acid. The present disclosure provides a stabilized composition comprising a bassorin-containing gum and caprylhydroxamic acid. The present disclosure provides a stabilized composition comprising Astragalus gummifer gum and caprylhydroxamic acid.

[0029] While caprylhydroxamic acid may be known in the skin care industry to be useful for inhibiting mold and microbial growth in skin care products, the inventors unexpectedly discovered that combining caprylhydroxamic acid with karaya gum can stabilize the viscosity of the composition when compared with karaya gum in the absence of the caprylhydroxamic acid. Caprylhydroxamic acid is unexpectedly good at stabilizing viscosity in compositions including karaya gum, particularly when compared with some alternatives that were attempted throughout the inventive process. Other natural gums, modified starches, amino acids, alcohols, and glycols were all evaluated as possible viscosity stabilizers for karaya gum, and none were capable of stabilizing the viscosity, emphasizing the unexpected nature of the inventive stability.

[0030] The present disclosure provides a method of improving viscosity stability in a composition comprising karaya gum and / or a bassorin-containing gum and / or Astragalus gummifer gum. The method includes introducing caprylhydroxamic acid to the composition to produce a stabilized composition. It should be appreciated that introducing caprylhydroxamic acid to the composition can be accomplished by introducing a powder that including both: i) the karaya gum and / or the bassorin-containing gum and / or the Astragalus gummifer gum; and ii) the caprylhydroxamic acid.

[0031] The present disclosure provides methods of using a stabilized composition. Without wishing to be bound by any particular theory, the methods of using the stabilized compositions disclosed herein may be purposed to show the unexpectedly significant improved stability achieved by the disclosed invention. The inventors unexpectedly discovered that combinations ofone or more of the disclosed gums and caprylhydroxamic acid provides unexpectedly good viscosity stability upon exposure to either UV light or elevated temperatures.

[0032] In one aspect, a method of using a stabilized composition as disclosed herein can include: exposing the stabilized composition to an elevated temperature for a predetermined temperature length of time. The elevated temperature is 45 °C, though it is expected that the disclosed stabilized composition achieves enhanced viscosity stability at other elevated temperatures and the present disclosure expressly contemplates stability at other temperatures. The predetermined temperature length of time can be at least 5 days, at least 10 days, at least 15 days, at least 20 days, at least 25 days, at least 30 days, at least 35 days, at least 40 days, at least 45 days, at least 50 days, at least 60 days, at least 70 days, at least 75 days, or more. The viscosity of the stabilized composition after the predetermined temperature length of time is at least 75%, at least 80%, at least 85%, at least 90%, or at least 95% of original viscosity.

[0033] In one aspect, a method of using a stabilized composition as disclosed herein can include: exposing the stabilized composition to UV irradiation at 60 W / m with wavelength between 300 nm and 400 nm for a predetermined light length of time. The predetermined light length of time can be at least 6 hours, at least 12 hours, or more. The viscosity of the stabilized composition after the predetermined light length of time is at least 75%, at least 80%, at least 85%, at least 90%, or at least 95% of original viscosity.

[0034] In general, a gum component (e.g., karaya gum) can account for between 0.1% and 20.0% by weight of the stabilized composition. In general, the caprylhydroxamic acid can account for between 0.01% and 2.0% by weight of the stabilized composition.

[0035] In some cases, the stabilized composition includes karaya gum in an amount by weight of at least 0.1%, at least 0.2%, at least 0.4%, at least 0.5%, at least 0.75%, at least 0.9%, at least 1.0%, at least 1.5%, at least 2.0%, at least 2.5%, at least 3.0%, at least 4.0%, at least 5.0%, at least 6.0%, at least 7.0%, at least 7.5%, at least 8.0%, at least 9.0%, or at least 10.0%. In some cases, the stabilized composition includes karaya gum in an amount by weight of at most 20.0%, at most 18.0%, at most 17.5%, at most 16.0%, at most 15.0%, at most 13.5%, at most 12.5%, at most 12.0%, at most 11.0%, at most 10.0%, at most 9.0%, at most 8.0%, at most 7.0%, at most 6.0%, or at most 5.0%. In some cases, the stabilized composition includes karaya gum in an amount by weight of between 0.1% and 20.0%. In some cases, the karaya gum is present in the stabilized composition in an amount by weight of between 0.5% and 10.0%. In some cases, thekaraya gum is present in the stabilized composition in an amount by weight of between 10.0% and 20.0%. In some cases, the karaya gum is present in the stabilized composition in an amount by weight of between 1.0% and 5.0%. In some cases, the karaya gum is present in the stabilized composition in an amount by weight of between 2.5% and 12.5%.

[0036] In some cases, the stabilized composition includes bassorin-containing gum in an amount by weight of at least 0.1%, at least 0.2%, at least 0.4%, at least 0.5%, at least 0.75%, at least 0.9%, at least 1.0%, at least 1.5%, at least 2.0%, at least 2.5%, at least 3.0%, at least 4.0%, at least 5.0%, at least 6.0%, at least 7.0%, at least 7.5%, at least 8.0%, at least 9.0%, or at least 10.0%. In some cases, the stabilized composition includes bassorin-containing gum in an amount by weight of at most 20.0%, at most 18.0%, at most 17.5%, at most 16.0%, at most 15.0%, at most 13.5%, at most 12.5%, at most 12.0%, at most 11.0%, at most 10.0%, at most 9.0%, at most 8.0%, at most 7.0%, at most 6.0%, or at most 5.0%. In some cases, the stabilized composition includes bassorin-containing gum in an amount by weight of between 0.1% and 20.0%. In some cases, the bassorin-containing gum is present in the stabilized composition in an amount by weight of between 0.5% and 10.0%. In some cases, the bassorin-containing gum is present in the stabilized composition in an amount by weight of between 10.0% and 20.0%. In some cases, the bassorin-containing gum is present in the stabilized composition in an amount by weight of between 1.0% and 5.0%. In some cases, the bassorin-containing gum is present in the stabilized composition in an amount by weight of between 2.5% and 12.5%.

[0037] In some cases, the stabilized composition includes Astragalus gummifer gum in an amount by weight of at least 0.1%, at least 0.2%, at least 0.4%, at least 0.5%, at least 0.75%, at least 0.9%, at least 1.0%, at least 1.5%, at least 2.0%, at least 2.5%, at least 3.0%, at least 4.0%, at least 5.0%, at least 6.0%, at least 7.0%, at least 7.5%, at least 8.0%, at least 9.0%, or at least 10.0%. In some cases, the stabilized composition includes Astragalus gummifer gum in an amount by weight of at most 20.0%, at most 18.0%, at most 17.5%, at most 16.0%, at most 15.0%, at most 13.5%, at most 12.5%, at most 12.0%, at most 11.0%, at most 10.0%, at most 9.0%, at most 8.0%, at most 7.0%, at most 6.0%, or at most 5.0%. In some cases, the stabilized composition includes Astragalus gummifer gum in an amount by weight of between 0.1% and 20.0%. In some cases, the Astragalus gummifer gum is present in the stabilized composition in an amount by weight of between 0.5% and 10.0%. In some cases, the Astragalus gummifer gum is present in the stabilized composition in an amount by weight of between 10.0% and 20.0%. Insome cases, the Astragalus gummifer gum is present in the stabilized composition in an amount by weight of between 1.0% and 5.0%. In some cases, the Astragalus gummifer gum is present in the stabilized composition in an amount by weight of between 2.5% and 12.5%.

[0038] In some cases, the stabilized composition includes the caprylhydroxamic acid in an amount by weight of at least 0.01%, at least 0.05%, at least 0.1%, at least 0.2%, at least 0.3%, at least 0.4%, or at least 0.5%. In some cases, the stabilized composition includes the caprylhydroxamic acid in an amount by weight of at most 2.0%, at most 1.9%, at most 1.75%, at most 1.6%, at most 1.5%, at most 1.4%, at most 1.3%, at most 1.25%, at most 1.1%, at most 1.0%, at most 0.9%, at most 0.8%, at most 0.75%, at most 0.7%, at most 0.6%, or at most 0.5%.

[0039] Without wishing to be bound by any particular theory, it is believed that a ratio by weight of the karaya gum (or the bassorin-containing gum or the Astragalus gummifer gum) to the caprylhydroxamic acid can be relevant to the enhanced viscosity stability. In some cases, the ratio by weight of the karaya gum or the bassorin-containing gum or the Astragalus gummifer gum to the caprylhydroxamic acid is at least 1:1 and at most 100:1. In some cases, the ratio by weight of the karaya gum or the bassorin-containing gum or the Astragalus gummifer gum to the caprylhydroxamic acid is at least 1:1, at least 2:1, at least 3:1, at least 4:1, at least 5:1, at least 6:1, at least 7:1, at least 8:1, at least 9:1, or at least 10:1. In some cases, the ratio by weight of the karaya gum or the bassorin-containing gum or the Astragalus gummifer gum to the caprylhydroxamic acid is at most 100:1, at most 90:1, at most 80:1, at most 70:1, at most 60:1, or at most 50:1. In some cases, the ratio by weight of the karaya gum or the bassorin-containing gum or the Astragalus gummifer gum to the caprylhydroxamic acid is at least 9:1 and at most 24:1.

[0040] The stabilized composition can include a polyol material. Without wishing to be bound by any particular theory, it is believed that the polyol material may enhance the material properties of the stabilized composition. However, as evidenced by the Examples below, the polyol material itself is not responsible of the unexpectedly improved viscosity stability shown by the disclosed stabilized composition. The polyol material can be or can include propanediol. The polyol material can be present in the stabilized composition in an amount by weight of at least 0.1%, at least 0.2%, at least 0.5%, at least 1.0%, or at least 2.0%. The polyol material can be present in the stabilized composition in an amount by weight of at most 10.0%, at most 9.0%, at most 7.5%, at most 5.0%, or at most 3.0%. In some cases, the polyol material is present in thestabilized composition in an amount by weight of between 0.1% and 10.0%. In some cases, the polyol material is present in the stabilized composition in an amount by weight of between 1.0% and 5.0%.

[0041] Consistent with the above-referenced methods of using the stabilized composition and the Examples outlined below, the stabilized composition has unexpectedly stable viscosity when exposed to elevated temperatures or UV light. In some cases, the stabilized composition maintains at least 75%, at least 80%, at least 85%, at least 90%, or at least 95% of original viscosity following storage at an elevated temperature of 45 °C for a predetermined temperature length of time of at least 5 days, at least 10 days, at least 15 days, at least 20 days, at least 25 days, at least 30 days, at least 35 days, at least 40 days, at least 45 days, at least 50 days, at least 60 days, at least 70 days, at least 75 days, or more. In some cases, the stabilized composition maintains at least 75%, at least 80%, at least 85%, at least 90%, or at least 95% of original viscosity following UV irradiation at 60 W / m with wavelength between 300 nm and 400 nm for a predetermined light length of time of at least 6 hours, at least 12 hours, or more.

[0042] The stabilized composition includes water. The water can be present in an amount that produces a desired viscosity.

[0043] The stabilized composition can include active ingredients, for example niacinamide, retinol, ascorbic acid derivatives, tocopherol derivatives, Alpha & Beta Hydroxy Acid (AHA & BHA) hyaluronic acid, resveratrol, bisabolol, bakuchiol, ceramides, kojic acid, ferulic acid, ethyl ferulate, glycolic acid or peptides. The stabilized composition can include humectants and emollients, such as for example glycerin, propylene glycol, butylene glycol, pentylene glycol, propanediol, butyrospermum arkii butter, canola oil, theobroma cacao butter, and other vegetable butters, cocos nucifera oil, helianthus annuus seed oil, brassica campestris seed oil, Gossypium Herbaceum seed oil, and other vegetable oils, hydrogenated vegetable oil, hydrogenated coco- glycerides, but also silicones (Cyclopentasiloxane or dimethicone), or esters (Caprylic / Capric Triglyceride, isopropyl palmitate, isopropyl myristate, diisopropyl adipate, Cl 2- 15 alkyl benzoate). The stabilized composition can include dyes & pigments, such as for example CI 77891, CI 77947, CI 19140, CI 15985, CI 17200, CI 14700, CI 16035, CI 60730, CI 42090, CI 75300, CI 75810, CI 40800, CI 75120, CI 77491, CI 77492, CI 77499, CI 77007, CI 77019). The stabilized composition can include fragrance. The stabilized composition can include UV filters, such as for example 4-amino-benzoic acid (PABA), benzalkonium camphor methosulfate,homosalate, 2-hydroxy-4-methoxybenzophenone (benzophenone-3), phenylbenzimidazole sulfonic acid, terephthalylidene dicamphersulfonic acid, butyl methoxydibenzoylmethane, benzylidene camphorsulfonic acid, octocrylene, polyacrylamidomethyl benzylidene camphor, ethylhexyl methoxycinnamate, PEG-25 4-aminobenzoic acid, isoamyl p-methoxycinnamate, ethylhexyl triazone, trisiloxane drometzol, diethylhexyl-butamido-triazone, 4-methylbenzylidene camphor, 3-benzylidene camphor, ethylhexyl salicylate, ethylhexyl dimethyl PABA, 5-Benzoyl- 4-hydroxy-2-methoxybenzenesulfonic acid (Benzophenone-4), the sodium salt of 2-hydroxy-4- methoxybenzophenone-5 -sulfonic acid (Benzophenone-5), bis-benzotriazolyl tetramethylb methylene utylphenol, phenyl-dibenzimidazole disodium tetrasulfonate, bis-ethylhexyloxyphenol methoxyphenyl triazine, polysilicone-15 or diethylamino-hydroxybenzoyl-hex yl benzoate. The stabilized composition can include surfactants, such as for example PEG-40 hydrogenated castor oil, PPG-26 buteth-26, decyl glucoside, coco glucoside, caprylyl / capryl glucoside, sucrose laurate, sucrose stearate, polyglyceryl-4 caprate, polyglyceryl-4 oleate, poly glyceryl- 10 oleate, polyglyceryl-4 laurate, sodium laureth sulfate, sodium lauryl sulfate, sodium cocoyl glutamate, ammonium lauryl sulfate, odium oleth sulfate, cocamidopropyl betaine, coco-betaine, sodium coco sulfate, odium lauroyl sarcosinate, disodium lauryl sulfosuccinate, disodium laureth sulfosuccinate, disodium cocoamphodiacetate, sodium lauryl sulfoacetate, glyceryl caprylate, glyceryl oleate, glyceryl caprate, polyglyceryl-3 diisostearate, or potassium cetyl phosphate. The stabilized composition can include other additives known to be useful in formulating compositions that are known to usefully incorporate karaya gum (See International Cosmetic Ingredient Dictionary and Handbook, which is incorporated by reference in its entirety for all purposes).

[0044] The present disclosure provides a product including the compositions disclosed herein. The product can be a cosmetic product, an industrial product, a food product, a pharmaceutical product, or a combination thereof. The product can be a cosmetic product, such as a personal care product, a fragrance product, a skin care product, a body care product, a hair color product, a hair care product, a fragrance product, a make-up product, a sun care product (e.g., sunscreen, after sun, self-tanning), a rinse off product (e.g., shower gel, soaps, scrubs, shampoo, conditioner, hair color), make-up (e.g., lipstick, gloss, eyeshadow, blush, mascara, eyeliner, foundation, compact powder, primer), a hygiene product (e.g., oral care, mouthwash, deodorant, shaving), a fragrance product (e.g., solid fragrance, liquid fragrance, jellified eau de toilette, perfume), or acombination thereof. The product can be an industrial product, such as a home care product, an air care product, a cleanser product, a dishwasher product, a fabric care product, a surface care product, a toiler care product, or a combination thereof. The product can take the form of a serum, a gel, a lotion, a toner, a cream, a balm, a dermocosmetic, or the like. When formulated in product form, a skilled artisan will recognize that a wide variety of possible end formulations are contemplated (See Handbook of Cosmetic Science and Technology, which is incorporated by reference in its entirety for all purposes).

[0045] The present disclosure provides a dry particulate composition comprising powdered karaya gum (and / or powdered bassorin-containing gum and / or powdered Astragalus gummifer gum) and powdered caprylhydroxamic acid. The dry particulate composition can be hydrated by way of addition to water or an aqueous formulation such as the products described above. The dry particulate composition can include the powdered karaya gum and powdered caprylhydroxamic acid in the ratios articulated above.

[0046] All methods described herein can be performed in any suitable order unless otherwise indicated herein or otherwise clearly contradicted by context. The use of any and all examples, or exemplary language (e.g., “such as”) provided herein, is intended merely to better illuminate the invention and does not pose a limitation on the scope of the invention unless otherwise claimed. No language in the specification should be construed as indicating any non-claimed element as essential to the practice of the invention.

[0047] All references, including publications, patent applications, and patents, cited herein are hereby incorporated by reference to the same extent as if each reference were individually and specifically indicated to be incorporated by reference and were set forth in its entirety herein.

[0048] Preferred aspects of this invention are described herein, including the best mode known to the inventors for carrying out the invention. Variations of those preferred aspects may become apparent to those of ordinary skill in the art upon reading the foregoing description. The inventors expect a person having ordinary skill in the art to employ such variations as appropriate, and the inventors intend for the invention to be practiced otherwise than as specifically described herein. Accordingly, this invention includes all modifications and equivalents of the subject matter recited in the claims appended hereto as permitted by applicable law. Moreover, any combination of the above-described elements in all possible variationsthereof is encompassed by the invention unless otherwise indicated herein or otherwise clearly contradicted by context.

[0049] While the invention has been illustrated and described in detail in the foregoing drawings and description, the same is to be considered as illustrative and not restrictive in character, it being understood that only illustrative embodiments thereof have been shown and described and that all changes and modifications that come within the spirit of the invention are desired to be protected. For example, any of the features or functions of any of the embodiments disclosed herein may be incorporated into any of the other embodiments disclosed herein.

[0050] The following examples illustrate some embodiments and aspects of the invention. It will be apparent to those skilled in the relevant art that various modifications, additions, substitutions, and the like can be performed without altering the spirit or scope of the invention, and such modifications and variations are encompassed within the scope of the invention as defined in the claims which follow. The following examples do not in any way limit the invention.EXAMPLES

[0051] Example 1: Temperature Stability

[0052] Method of preparation: Karaya gum and caprylyhydroxamic acid are first premixed in a glycol, such as for example propanediol. The premix is then introduced into water while stirring at a speed of between 200-300 rpm for 15 minutes. The speed is then increased up to 1000 rpm and maintained for 30-60 min. The resulting compositions include: 3% karaya / 20% ethanol; 3% karaya / 3% glycerol; 3% karaya / 3% propylene glycol; 3% karaya / 3% pentylene glycol; 3% karaya / 3% butylene glycol; 3% karaya / 3% propanediol; 3% karaya / 3% Zeastat® (i.e., 0.3% caprylhydroxamic acid and 2.7% propanediol).

[0053] Referring to Fig. 1, the viscosity of the inventive composition (Karaya / Zeastat®) and comparative examples are plotted against the length of time in days that the compositions were stored at 45 °C.

[0054] Given that the inventive composition contains both caprylhydroxamic acid and propanediol, the inventors prepared compositions with a constant 3% of karaya gum and 3% of propanediol, while varying the caprylhydroxamic acid content (0%, 0.1%, 0.2%, and 0.3%). The resulting compositions include: 3% karaya / 3% propanediol; 3% karaya / 0.1% caprylhydroxamicacid / 3% propanediol; 3% karaya / 0.2% caprylhydroxamic acid / 3% propanediol; and 3% karaya / 0.3% caprylhydroxamic acid / 3% propanediol. Referring to Fig. 2, the viscosity of these compositions are plotted against the length of time in days that the compositions were stored at 45 °C.

[0055] By way of comparison, a composition including only 3% karaya gum without any caprylhydroxamic acid (or other component) shows significant viscosity degradation following storage at 45 °C as reported in Table 1.Table 1

[0056] Example 2: Light Stability

[0057] Artificial UV exposure was performed on the following formulations described above: 3% karaya / 3% propanediol; 3% karaya / 0.1% caprylhydroxamic acid / 3% propanediol; 3% karaya / 0.2% caprylhydroxamic acid / 3% propanediol; and 3% karaya / 0.3% caprylhydroxamic acid / 3% propanediol.

[0058] Referring to Fig. 3, the viscosity of the compositions before and after a 6 hour exposure to 300-400 nm light having an intensity of 60 W / cm . These results illustrate the stabilization capability of the combination of karaya gum and caprylhydroxamic acid and show that the caprylhydroxamic acid and not the propanediol is responsible for the unexpected stability.

[0059] While the disclosure has been disclosed in connection with the preferred embodiments shown and described in detail, various modifications and improvements thereon will become readily apparent to those skilled in the art. Accordingly, the spirit and scope of the present disclosure is not to be limited by the foregoing examples, but is to be understood in the broadest sense allowable by law.

Claims

CLAIMSWe claim:

1. A stabilized composition comprising: karaya gum; and caprylhydroxamic acid.

2. A method of improving viscosity stability in a composition comprising karaya gum, the method comprising: introducing caprylhydroxamic acid to the composition to produce a stabilized composition.

3. A method of using a stabilized composition, the stabilized composition comprising karaya gum and caprylhydroxamic acid, the method comprising: exposing the stabilized composition to an elevated temperature for a predetermined temperature length of time, wherein the elevated temperature is 45 °C, wherein the predetermined temperature length of time is at least 5 days, at least 10 days, at least 15 days, at least 20 days, at least 25 days, at least 30 days, at least 35 days, at least 40 days, at least 45 days, at least 50 days, at least 60 days, at least 70 days, at least 75 days, or more, wherein viscosity of the stabilized composition after the predetermined temperature length of time is at least 75%, at least 80%, at least 85%, at least 90%, or at least 95% of original viscosity.

4. A method of using a stabilized composition, the stabilized composition comprising karaya gum and caprylhydroxamic acid, the method comprising: exposing the stabilized composition to UV irradiation at 60 W / m with wavelength between 300 nm and 400 nm for a predetermined light length of time, wherein the predetermined light length of time is at least 6 hours, at least 12 hours, or more, wherein viscosity of the stabilized composition after the predetermined light length of time is at least 75%, at least 80%, at least 85%, at least 90%, or at least 95% of original viscosity.

5. The stabilized composition or method of any one of the preceding claims, wherein the karaya gum is present in the stabilized composition in an amount by weight of between 0.1% and 20.0%.

6. The stabilized composition or method of any one of claims 1 to 4, wherein the karaya gum is present in the stabilized composition in an amount by weight of between 0.5% and 10.0%.

7. The stabilized composition or method of any one of claims 1 to 4, wherein the karaya gum is present in the stabilized composition in an amount by weight of between 10.0% and20.0%.

8. The stabilized composition or method of any one of claims 1 to 4, wherein the karaya gum is present in the stabilized composition in an amount by weight of between 1.0% and 5.0%.

9. The stabilized composition or method of any one of claims 1 to 4, wherein the karaya gum is present in the stabilized composition in an amount by weight of between 2.5% and 12.5%.

10. The stabilized composition or method of any one of claims 1 to 4, wherein the karaya gum is present in the stabilized composition in an amount by weight of at least 0.1%, at least 0.2%, at least 0.4%, at least 0.5%, at least 0.75%, at least 0.9%, at least 1.0%, at least 1.5%, at least 2.0%, at least 2.5%, at least 3.0%, at least 4.0%, at least 5.0%, at least 6.0%, at least 7.0%, at least 7.5%, at least 8.0%, at least 9.0%, or at least 10.0% and at most 20.0%, at most 18.0%, at most 17.5%, at most 16.0%, at most 15.0%, at most 13.5%, at most 12.5%, at most 12.0%, at most 11.0%, at most 10.0%, at most 9.0%, at most 8.0%, at most 7.0%, at most 6.0%, or at most 5.0%.

11. A stabilized composition comprising: a bassorin-containing gum; and caprylhydroxamic acid.

12. A method of improving viscosity stability in a composition comprising a bassorin- containing gum, the method comprising: introducing caprylhydroxamic acid to the composition to produce a stabilized composition.

13. A method of using a stabilized composition, the stabilized composition comprising bassorin-containing gum and caprylhydroxamic acid, the method comprising: exposing the stabilized composition to an elevated temperature for a predetermined temperature length of time, wherein viscosity of the stabilized composition after the predetermined temperature length of time is at least 75%, at least 80%, at least 85%, at least 90%, or at least 95% of original viscosity.

14. A method of using a stabilized composition, the stabilized composition comprising bassorin-containing gum and caprylhydroxamic acid, the method comprising: exposing thestabilized composition to UV irradiation at 60 W / m with wavelength between 300 nm and 400 nm for a predetermined light length of time, wherein viscosity of the stabilized composition after the predetermined light length of time is at least 75%, at least 80%, at least 85%, at least 90%, or at least 95% of original viscosity.

15. The stabilized composition or method of any one of claims 11 to 14, wherein the bassorin-containing gum is present in the stabilized composition in an amount by weight of between 0.1% and 20.0%.

16. The stabilized composition or method of any one of claims 11 to 14, wherein the bassorin-containing gum is present in the stabilized composition in an amount by weight of between 0.5% and 10.0%.

17. The stabilized composition or method of any one of claims 11 to 14, wherein the bassorin-containing gum is present in the stabilized composition in an amount by weight of between 10.0% and 20.0%.

18. The stabilized composition or method of any one of claims 11 to 14, wherein the bassorin-containing gum is present in the stabilized composition in an amount by weight of between 1.0% and 5.0%.

19. The stabilized composition or method of any one of claims 11 to 14, wherein the bassorin-containing gum is present in the stabilized composition in an amount by weight of between 2.5% and 12.5%.

20. The stabilized composition or method of any one of claims 11 to 14, wherein the bassorin-containing gum is present in the stabilized composition in an amount by weight of at least 0.1%, at least 0.2%, at least 0.4%, at least 0.5%, at least 0.75%, at least 0.9%, at least 1.0%, at least 1.5%, at least 2.0%, at least 2.5%, at least 3.0%, at least 4.0%, at least 5.0%, at least 6.0%, at least 7.0%, at least 7.5%, at least 8.0%, at least 9.0%, or at least 10.0% and at most 20.0%, at most 18.0%, at most 17.5%, at most 16.0%, at most 15.0%, at most 13.5%, at most 12.5%, at most 12.0%, at most 11.0%, at most 10.0%, at most 9.0%, at most 8.0%, at most 7.0%, at most 6.0%, or at most 5.0%.

21. A stabilized composition comprising: Astragalus gummifer gum; and caprylhydroxamic acid.16l. A method of improving viscosity stability in a composition comprising Astragalus gummifer gum, the method comprising: introducing caprylhydroxamic acid to the composition to produce a stabilized composition.

23. A method of using a stabilized composition, the stabilized composition comprising Astragalus gummifer gum and caprylhydroxamic acid, the method comprising: exposing the stabilized composition to an elevated temperature for a predetermined temperature length of time, wherein viscosity of the stabilized composition after the predetermined temperature length of time is at least 75%, at least 80%, at least 85%, at least 90%, or at least 95% of original viscosity.

24. A method of using a stabilized composition, the stabilized composition comprising Astragalus gummifer gum and caprylhydroxamic acid, the method comprising: exposing the stabilized composition to UV irradiation at 60 W / m with wavelength between 300 nm and 400 nm for a predetermined light length of time, wherein viscosity of the stabilized composition after the predetermined light length of time is at least 75%, at least 80%, at least 85%, at least 90%, or at least 95% of original viscosity.

25. The stabilized composition or method of any one of the preceding claims, wherein the Astragalus gummifer gum is present in the stabilized composition in an amount by weight of between 0.1% and 20.0%.

26. The stabilized composition or method of any one of claims 21 to 24, wherein the Astragalus gummifer gum is present in the stabilized composition in an amount by weight of between 0.5% and 10.0%.

27. The stabilized composition or method of any one of claims 21 to 24, wherein the Astragalus gummifer gum is present in the stabilized composition in an amount by weight of between 10.0% and 20.0%.

28. The stabilized composition or method of any one of claims 21 to 24, wherein the Astragalus gummifer gum is present in the stabilized composition in an amount by weight of between 1.0% and 5.0%.

29. The stabilized composition or method of any one of claims 21 to 24, wherein the Astragalus gummifer gum is present in the stabilized composition in an amount by weight of between 2.5% and 12.5%.Y130. The stabilized composition or method of any one of claims 21 to 24, wherein the Astragalus gummifer gum is present in the stabilized composition in an amount by weight of at least 0.1%, at least 0.2%, at least 0.4%, at least 0.5%, at least 0.75%, at least 0.9%, at least 1.0%, at least 1.5%, at least 2.0%, at least 2.5%, at least 3.0%, at least 4.0%, at least 5.0%, at least 6.0%, at least 7.0%, at least 7.5%, at least 8.0%, at least 9.0%, or at least 10.0% and at most 20.0%, at most 18.0%, at most 17.5%, at most 16.0%, at most 15.0%, at most 13.5%, at most 12.5%, at most 12.0%, at most 11.0%, at most 10.0%, at most 9.0%, at most 8.0%, at most 7.0%, at most 6.0%, or at most 5.0%.

31. The stabilized composition or method of any one of the preceding claims, the stabilized composition further comprising a polyol material.

32. The stabilized composition or method of claim 31 , wherein the polyol material is or comprises propanediol.

33. The stabilized composition or method of claim 31 or 32, wherein the polyol material is present in the stabilized composition in an amount by weight of between 0.1% and 10.0%, including but not limited to an amount by weight of at least 0.1%, at least 0.2%, at least 0.5%, at least 1.0%, or at least 2.0% and at most 10.0%, at most 9.0%, at most 7.5%, at most 5.0%, or at most 3.0%.

34. The stabilized composition or method of claim 31 or 32, wherein the polyol material is present in the stabilized composition in an amount by weight of between 1.0% and 5.0%.

35. The stabilized composition or method of any one of the preceding claims, wherein the caprylhydroxamic acid is present in the stabilized composition in an amount by weight of between 0.01% and 2.0%, including but not limited to, at least 0.01%, at least 0.05%, at least 0.1%, at least 0.2%, at least 0.3%, at least 0.4%, or at least 0.5% and at most 2.0%, at most 1.9%, at most 1.75%, at most 1.6%, at most 1.5%, at most 1.4%, at most 1.3%, at most 1.25%, at most 1.1%, at most 1.0%, at most 0.9%, at most 0.8%, at most 0.75%, at most 0.7%, at most 0.6%, or at most 0.5%.

36. The stabilized composition or method of any one of the preceding claims, wherein the caprylhydroxamic acid is present in the stabilized composition in an amount by weight of between 0.05% and 0.25%.1837. The stabilized composition or method of any one of the preceding claims, wherein a ratio by weight of the karaya gum or the bassorin-containing gum or the Astragalus gummifer gum to the caprylhydroxamic acid is at least 1:1 and at most 100:1, including but not limited to, at least 1:1, at least 2:1, at least 3:1, at least 4:1, at least 5:1, at least 6:1, at least 7:1, at least 8:1, at least 9:1, or at least 10:1 and at most 100:1, at most 90:1, at most 80:1, at most 70:1, at most 60:1, or at most 50:1.

38. The stabilized composition or method of any one of the preceding claims, wherein a ratio by weight of the karaya gum or the bassorin-containing gum or the Astragalus gummifer gum to the caprylhydroxamic acid is at least 9:1 and at most 24:1.

39. The stabilized composition or method of any one of the preceding claims, wherein the stabilized composition maintains at least 75%, at least 80%, at least 85%, at least 90%, or at least 95% of original viscosity following storage at an elevated temperature of 45 °C for a predetermined temperature length of time of at least 5 days, at least 10 days, at least 15 days, at least 20 days, at least 25 days, at least 30 days, at least 35 days, at least 40 days, at least 45 days, at least 50 days, at least 60 days, at least 70 days, at least 75 days, or more.

40. The stabilized composition or method of any one of the preceding claims, wherein the stabilized composition maintains at least 75%, at least 80%, at least 85%, at least 90%, or at least 95% of original viscosity following UV irradiation at 60 W / m with wavelength between 300 nm and 400 nm for a predetermined light length of time of at least 6 hours, at least 12 hours, or more.

41. A cosmetic product comprising the stabilized composition of or made by the method of any one of the preceding claims.

42. A dry particulate composition comprising powdered karaya gum and powdered caprylhydroxamic acid, wherein a ratio by weight of the karaya gum to the caprylhydroxamic acid is at least 9: 1 and at most 24: 1.19

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