Composition for hair strengthening

Abstract

Described herein is a process using a novel composition for strengthening hair by crosslinking the free thiols naturally present on hair or resulting from the reduction of disulfide bonds in damaged or treated hair. The process involves applying a composition containing an active agent that interacts with free thiols present in hair, forming a covalent carbon-sulphur bond, thereby enhancing the structural integrity of hair. The present invention provides a rinse off or leave-in treatment that effectively reduces breakage and restores strength to weakened or damaged hair and helps in increased longevity of reshaped hair such as straightening or curling.

Description

[0001]“COMPOSITION FOR HAIR STRENGTHENING” Field of Invention: The current invention is in field of strengthening of hair. More particularly, the 5 current invention provides a composition for crosslinking the broken disulfide bonds in treated or damaged hair. Background of Invention: Since ancient times, straightening hair has been known to make hair appear 10 lustrous, streamlined, and sleek. Hair reshaping is traditionally accomplished by a variety of procedures, such as using a flat iron or hot comb, chemical relaxers, Brazilian or Japanese hair straightening techniques, or roller set / blow dryer styling. 15 These techniques can be broadly categorized as “Chemical Methods,” which cause the hair to reshape, and “Non-Chemical Methods,” which result in temporary straightening of the hair. The above-mentioned non-chemical techniques include using a flat iron, hot 20 comb, or roller set / blow dryer styling. With the use of these procedures, hair is briefly heated, denaturing the keratin and giving the illusion of straighter hair. The keratin quickly reverts to its original state when it comes into contact with its surroundings. 25 On the other hand, chemical techniques such as Brazilian treatments, RedOx treatments, and hair relaxing last longer. Using a hot flat iron after applying a cross-linking chemical to the hair such as formaldehyde, glyoxyloyl carbocysteine, or glyoxylic acid is the Brazilian keratin 30 treatment. The cross-linking agent helps the reactive groups in the keratin of hair to connect with one another. The treatment lessens frizz, straightens hair, and improves luster. The result lasts for about half a year, after which there is a slow return to the natural texture of the hair. Redox processes involve the transfer of electrons among the constituents of aqueous, gaseous, and solid phases. The hair goes through a number of steps in 5 the RedOx treatment process in order to achieve structural modification. To effectively reduce the disulphide bonds in cystine into thiols, or convert cystine to cysteines (-RSH), a reducing agent chosen from thioglycolic acid or a salt thereof, thioglycerol, cysteamine, and cysteine or its salt, inorganic sulphites, is applied for 45 minutes to an hour. After that, heat is applied and the hair is stretched to 10 realign the thiols. The last stage involves using H2O2 to oxidize the thiols, which makes it easier for the disulphide bonds (R-S-S-R) to form at the new sites. Due to the instability of the disulphide bonds in the new locations, hair treated in this manner would curl back. The reduction step (step 1) has a pH of approximately 8.5–9.5, while the oxidation step (step 2) is done at a pH of approximately 3. The 15 treatment takes two to three hours to complete. The ionic metals include sodium, lithium, and potassium. These metals are combined with oxygen and hydrogen, forming ionic compounds known as relaxers which include the following active ingredients: sodium hydroxide 20 (NaOH), potassium hydroxide (KOH), and lithium hydroxide (LiOH) in the pH range of 12-14. It is the hydroxide ion, which is the alkaline chemical species common to all the above-listed relaxers. Hair keratin contains a disulphide cystine(R-S-S-R) that is attacked by the hydroxide ion. This results in the formation of dehydroalanine and thiolate, which then combine to form a 25 lanthionine bond (R-S-R), releasing a sulphur atom and reshaping (straightening) hair. This process is known as beta elimination analysis. The abovementioned techniques lead to permanent or temporary damaging of hair caused due to breaking of disulphide cystine (R-S-S-R). The stability of the hair 30 style is also known to be reliant on disulfide bonds, which are prone to instability and can readily reduce to sulfhydryl groups in reducing conditions. Many attempts have been made to introduce oxidizing chemicals in an attempt to restore the disulfide bonds. Numerous compounds that enhance the stability of permanent waves rely on this technology. A significant amount of patents and patent applications, including US9095518 and WO2015017768, are also focused on the 5 restoration of disulfide bonds. For instance AU2017266787 relates to a method for strengthening hair and repairing keratin fibers, comprising providing a first crosslinking formula and a second crosslinking formula, wherein the first crosslinking formula contains a 10 Bronsted base with at least double functions, and the second formula contains an organic acid with at least double functions and a cosmetically acceptable carrier. However, said patent describes use of a two components, whereby the first components is a bi-functional Bronsted base and the component is a bi-functional organic acid which leads to strengthening of hair. However, the disclose process is 15 tedious which requires handling of two different components separately. In view of above, it would be prudent to develop such a formulation which is less tedious and give equal effective results at an affordable price which provides the long-lasting efficacy and durability of the treatment, contributing to enhance hair 20 health and manageability. Hence, in view of above, the current invention endeavours to overcome the above cited drawbacks of the prior art by providing a novel composition and method for treating and strengthening damaged hair and / or treated hair. 25 Summary of Invention: In view of above drawbacks of the prior art, in main aspect, the present invention provides a composition for strengthening hair by crosslinking the broken disulfide bonds in chemically (coloring, bleaching, hair reshaping) treated or damaged hair. 30 The process involves applying the active agent composition to the damaged or chemically (coloring, bleaching, hair reshaping) treated hair, wherein the active agent interacts with free thiol groups present in the hair and forms a carbon sulfur covalent bond In another aspect, the present invention provides a formulation for strengthening 5 of hair and the composition which requires a treatment time of approx.5 minutes before being rinsed off and which strengthens the hair. In yet another aspect, the present invention provides a leave-in formulation for strengthening of hair and the composition thereof. 10 The invention will now be described in detail in connection with certain preferred and optional embodiments, so that various aspects thereof may be more fully understood and appreciated. However, any skilled person will appreciate the 15 extent to which such embodiments could be extrapolated in practice. Unless specified otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art, to which this invention belongs. Although any methods and materials similar or 20 equivalent to those described herein can be used in the practice or testing of the present invention, the preferred methods and materials are described. Unless stated to the contrary, any of the words “contains”, “containing”, “including,” “includes,” “comprising,” and “comprises” mean “including without 25 limitation” and shall not be construed to limit any general statement that it follows to the specific or similar items or matters immediately following it. Embodiments of the invention are not mutually exclusive but may be implemented in various combinations. The described embodiments of the invention and the disclosed examples are given for the purpose of illustration rather than limitation of the 30 invention. Further, words like “a”, “an”, “at least” and “the” should be construed to not only cover singular quantities but also plural quantities of the elements immediately following them. 5 For the purpose of this specification, the terms “multi-functionalised active moiety” or “multi-functionalised active agent” or “active agent” encompasses such active compounds which are capable of reacting with at least two thiols to form covalent bonds, which include but are not limited to the derivatives of Michael acceptors like maleic acid, succinic acid, itaconic acid, fumaric acid, 10 acrylate, methacrylate, or reactive hetero aromatic compounds such as triazole, or electrophilic groups such as isocyanate, isothiocyanate, epoxide, alkene, or alkyne, or electrophilic group attached with charged amino acid, an electrophilic moiety containing a leaving group that has ability to attract electrons such as halogen, triazolyl, imidazole, phosphate, phosphonate, phosphinate, amide, imide, 15 amine, tosylate, hydroxyl, carbonate, carboxylate, urethane, urea, and ammonium. Such compounds are disclosed in co-pending Patent Application No. 202421009327. The terms “multi-functionalised active moiety” or “multi- functionalised active agent” or “active agent” are interchangeably used. 20 In accordance with the invention, the multi-functionalised active agent is an active agent which is disclosed in co-pending Patent Application No. 202421009327 having following general Structure I: ^^^^ − ^^ − ^^^^′(I) 25 wherein, FG, FG’ which are connected with a carbon chain (-R) and having reactive moieties on either end, capable of reacting to form covalent bonds with at least two thiols, which include but are not limited to the derivatives of Michael acceptors like maleic acid, succinic acid, itaconic acid, fumaric acid, acrylate, 30 methacrylate, or reactive hetero aromatic compounds such as triazole, or electrophilic groups such as isocyanate, isothiocyanate, epoxide, alkene, or alkyne, or electrophilic group attached with charged amino acid, an electrophilic moiety containing a leaving group that has ability to attract electrons such as halogen, triazolyl, imidazole, phosphate, phosphonate, phosphinate, amide, imide, amine, tosylate, hydroxyl, carbonate, carboxylate, urethane, urea, and ammonium, 5 and R = a spacer group selected from a straight or branched alkane, alkene, alkyne, or aromatic compound, or functionalised straight or branched alkane, alkene, alkyne :10: or aromatic compound wherein functionalisation could be amide or ester or 10 ether, heterocyclic or homocyclic group or carbon chains containing one or more heteroatoms such as N, S, O. The multi-functionalised active moiety could be triazole-activated dicarboxylic acids, wherein the dicarboxylic acid could be malonic acid, succinic acid, tartaric 15 acid, glutaric acid, adipic acid and combinations thereof. The alkene moiety as a Michael acceptor on the active molecule could be located, other than at the ends of the molecule and on its ends carry thiol groups e.g. dithio maleate whereby the thiol groups interact with thiols on either side of the hair 20 keratin forming disulfide bonds or one thiol on the active molecule can form a disulfide bond with one thiol on one side of hair keratin and the alkene site on the active molecule involves in Michael addition with another thiol on the other side of the hair keratin. 25 The multi-functionalised active agent forms a R1-S-R-S-R2Wherein R1and R2are sulphahydryl groups connected to cysteine moiety and R is spacer group. 30 The current invention describes a composition for hair strengthening which is based on formation of a carbon-sulphur bond between sulfhydryl or thiol group of the cysteine residue of the Keratin Protein and the terminal functional group of the multi-functionalised active agent. In an embodiment, the composition of the invention is a stand-alone composition 5 which is used for hair strengthening after treatments which include hair colouring, hair straightening, Keratin Treatment, Protein Treatment, Detox Treatment and like, whereby the treatment leads to temporary or permanent weakening or breaking of disulphide bonds. 10 Accordingly, the composition of the invention comprises of a multi-functionalised active agent which reforms the broken or weakened disulphide bonds thereby repairing damage and enhances strength of hair. The multi-functionalised active agent comprises of a spacer group which aids in enhancing the strength of hair. 15 In accordance to one of the embodiment, the hair strengthening composition can be formulated as a rinse-off composition or a leave-in composition. In an embodiment, the composition of the invention is a rinse-off composition. The said rinse-off composition is applied for short duration of time approx.5 min. 20 The rinse-off composition comprises of a multi-functionalised active agent, one or more surfactants. Further, the composition comprises one or more cosmetically acceptable excipients containing emulsifiers, thickeners, polyols, humectants, pH adjusting agent, conditioning agent, silicones, emollients, oils, water, preservatives and fragrance. 25 In subsequent embodiment, the invention provides a process for strengthening of hair, by using the rinse-off composition, comprises following steps: a. applying the composition containing the active agent of Structure 1, on wet hair; 30 b. leaving the product of step (a) for approx.5 mins, and c. rinsing the hair. The rinse-off formulation comprises of: a. an active agent; b. a thickening agent; c. a surfactant, or emulsifier 5 The composition may additionally contain emollient and conditioning agent. Accordingly, the active agent is a multi-functionalised active agent which is disclosed in co-pending Patent Application No.202421009327 having following 10 general Structure I: ^^^^ − ^^ − ^^^^′(I) wherein, FG, FG’ which are connected with a carbon chain (-R) and having reactive 15 moieties on either end, capable of reacting to form covalent bonds with at least two thiols, which include but are not limited to the derivatives of Michael acceptors like maleic acid, succinic acid, itaconic acid, fumaric acid, acrylate, methacrylate, or reactive hetero aromatic compounds such as triazole, or electrophilic groups such as isocyanate, isothiocyanate, epoxide, alkene, or 20 alkyne, or electrophilic group attached with charged amino acid, an electrophilic moiety containing a leaving group that has ability to attract electrons such as halogen, triazolyl, imidazole, phosphate, phosphonate, phosphinate, amide, imide, amine, tosylate, hydroxyl, carbonate, carboxylate, urethane, urea, and ammonium, and 25 R = a spacer group selected from a straight or branched alkane, alkene, alkyne, or aromatic compound, or functionalised straight or branched alkane, alkene, alkyne :10: or aromatic compound wherein functionalisation could be amide or ester or ether, heterocyclic or homocyclic group or carbon chains containing one or more 30 heteroatoms such as N, S, O. The active agent concentration is preferably 0.1 wt.% to 30 wt.%, more preferably 1 wt.% to 20 wt.%, and most preferably 0.2 wt.% to 10 wt.%. The thickening agent is selected from, but not limited to synthetic polymers such 5 as polyethylene glycol, acrylic acid based, poloxamer, semi-synthetic polymer such as hydroxyethyl cellulose, natural polymers such as xanthan gum, carrageenan, PEG-150 distearate, and salt such as sodium chloride and combination thereof. 10 The thickening agent concentration is preferably 0.1 wt.% to 10wt.%, more preferably 0.2 wt.% to 8wt.%, and most preferably 0.2 wt.% to 5wt.%. The conditioning agent is selected from, but not limited to dimethicone, dimethiconol, amodimethicone, bis-aminopropyl dimethicone, Dipropylene 15 glycol, polysilicone-29, hydrolysed wheat protein, behentrimonium chloride, stearamidopropyl dimethylamine, and combinations thereof. The conditioning agent is included in an amount ranging preferably from 0.1 wt.% to 15 wt.%, more preferably 0.5 wt.% to 10 wt.%, most preferably 1 wt.% to 5 20 wt.%. The emollient is selected from, but not limited to polyols such as glycerin, propylene glycol hexylene glycol, caprylyl glycol, triglyceride such as caprylic / capric triglyceride, fatty acid ester such as cetyl palmitate. More than one 25 emollient may be included in the formulation. The emollient concentration is preferably 0.5 wt.% to 20 wt.%, more preferably 1 wt.% to 15 wt.%, most preferably 2wt.% to 10wt.%. 30 The surfactant is selected from but not limited to sodium lauryl sulfate, alkyl aryl sulfonates, isethionate, benzalkonium chloride, polyoxyethylene alkyl ethers, alkyl polyglucoside, polysorbates, polyoxyethylene monolaurate, cocoamidopropyl Betaine, lauryl betaine or combinations thereof. The active surfactant content is preferably 0.1 wt.% to 40wt.%, more preferably 5 2wt.% to 30 wt.%, most preferably 5wt.% to 25 wt.%. The emulsifier is selected from but not limited to cetearyl alcohol, ceteareth-20, glycol stearate, polysorbate-60, polysorbate-80, or combinations thereof. The emulsifier concentration is preferably 0.1 wt.% to 30wt.%, more preferably 10 1wt.% to 25wt.%, most preferably 2 wt.% to 15 wt.%. In an embodiment, the invention provides a leave-in hair strengthening composition. 15 In subsequent embodiment the invention provides a single step, leave-in process for strengthening of hair, comprises following steps; a. applying the composition with the active agent on wet / dry hair; and b. leaving the product of step (a) as such. 20 The leave-in formulation comprises of: a. an active agent; b. a thickening agent; c. an emulsifier. The composition may additionally contain an emollient, conditioning agent. 25 Accordingly, the active agent is a multi-functionalised active agent which is disclosed in co-pending Patent Application No.202421009327 having following general Structure I: ^^^^ − ^^ − ^^^^′30 (I) wherein, FG, FG’ which are connected with a carbon chain (-R) and having reactive moieties on either end, capable of reacting to form covalent bonds with at least two thiols, which include but are not limited to the derivatives of Michael acceptors like maleic acid, succinic acid, itaconic acid, fumaric acid, acrylate, 5 methacrylate, or reactive hetero aromatic compounds such as triazole, or electrophilic groups such as isocyanate, isothiocyanate, epoxide, alkene, or alkyne, or electrophilic group attached with charged amino acid, an electrophilic moiety containing a leaving group that has ability to attract electrons such as halogen, triazolyl, imidazole, phosphate, phosphonate, phosphinate, amide, imide, 10 amine, tosylate, hydroxyl, carbonate, carboxylate, urethane, urea, and ammonium, and R = a spacer group selected from a straight or branched alkane, alkene, alkyne, or aromatic compound, or functionalised straight or branched alkane, alkene, alkyne 15 or aromatic compound wherein functionalisation could be amide or ester or ether, heterocyclic or homocyclic group or carbon chains containing one or more heteroatoms such as N, S, O. The active agent concentration is preferably 0.1 wt.% to 30 wt.%, more preferably 20 1 wt.% to 20 wt.%, and most preferably 0.2 wt.% to 10 wt.%. The thickening agent is selected from, but not limited to synthetic polymers such as polyethylene glycol, acrylic acid based, poloxamer, semi-synthetic polymer such as hydroxyethyl cellulose, natural polymers such as xanthan gum, carrageenan, PEG-150 distearate, and combination thereof. 25 The thickening agent concentration is preferably 0.1 wt.% to 10wt.%, more preferably 0.2 wt.% to 8wt.%, and most preferably 0.2 wt.% to 5wt.%. The conditioning agent is selected from, but not limited to dimethicone, 30 dimethiconol, amodimethicone, bis-aminopropyl dimethicone, Dipropylene glycol, polysilicone-29, hydrolysed wheat protein, behentrimonium chloride, stearamidopropyl dimethylamine, and combinations thereof. The conditioning agent is included in an amount ranging preferably from 0.1 wt.% 5 to 15 wt.%, more preferably 0.5 wt.% to 10 wt.%, most preferably 1 wt.% to 5wt.%. The emollient is selected from, but not limited to polyols such as glycerin, propylene glycol hexylene glycol, caprylyl glycol, triglyceride such as 10 caprylic / capric triglyceride, fatty acid ester such as cetyl palmitate or combinations thereof. The emollient concentration is preferably 0.5 wt.% to 20 wt.%, more preferably 1 wt.% to 15 wt.%, most preferably 2wt.% to 10wt.%. 15 The emulsifier is selected from but not limited to cetearyl alcohol, ceteareth-20, glycol stearate, polysorbate-60, polysorbate-80, or combinations thereof. The emulsifier concentration is preferably 0.1 wt.% to 30wt.%, more preferably 20 1wt.% to 25wt.%, most preferably 2 wt.% to 15wt.%. In accordance with the above embodiment, the active agent formulation may be in any suitable form. Suitable forms include, but are not limited to, low to moderate viscosity liquids, lotions, milks, mousses, sprays, gels, creams, shampoos, 25 conditioners, and the like. The active agent will be present in a suitable container, which depends on the form of the formulation. In accordance with above embodiment, the pH of the composition is acidic to basic with pH varying from 3 to 10. 30 Advantages of Invention: The invention provides a composition for crosslinking the broken disulfide bonds in treated and / or damaged hair. The formation of carbon-sulfur covalent bond in the treated and / or damaged hair enhances its strength and integrity. The active 5 agent composition by crosslinking with thiols effectively prevents the reduction of disulfide bonds to free thiols present on hair for at least one week, three weeks, one month, or two months, or longer, after application of the composition. Thus, ensuring long-lasting efficacy of shaping of hair (curling or straightening) and durability of the treatment, contributing to enhanced hair health and 10 manageability. EXAMPLES Example 1: Table 1 Composition for crosslinking the broken disulfide bonds Leave-In Conditioner Composition S.No. Phase Ingredients % Method Of Manufacturing Demineralised Water (DM Weigh water, start stirring and A 1 Water) 73.5 add all the phase A ingredients 2 A Xiameter™ OFX 0193 Fluid 1.0 in MV. Start heating the MV at 3 A Disodium EDTA 0.1 75-80 degree C 4 B Ethyleneglycol Dimaleate 4.0 Premix phase B and heat the solution till it get solubilised and 5 B Propylene Glycol 2.0 transfer it to MV. 6 C Arlamol HD (Isohexadecane) 2.0 In SV, weigh all the phase B Xiameter PMX 200 Silicone ingredients and heat it to 75-80 C Fluid 100CST DC 200 degree Celsius. Ensure all the 7 100CST 1.0 ingredients are melted. Add it to 8 C Cetostearyl Alcohol 8.0 MV and start homogenisation. 9 C Ceteareth-20 1.0 Stearamidopropyl C 10 Dimethylamine 1.0 Xiameter (R) PMX 245 D 11 Cyclopentasiloxane 3.0 Add phase d ingredients one by 12 D Xiameter PMX 1501 / DC 1501 2.0 one to MV and keep on stirring Dowsil™ 556 Cosmetic Grade D 13 Fluid 1.0 14 E Microcare ITO 0.1 Add phase E to MV 15 F Fragrance 0.3 Add fragrance and stir at the end adjust the batch with F 16 pH adjuster q.s pH adjuster Total 100.0 Example 2: Table 2: Composition for crosslinking the broken disulfide bonds Leave-In Serum Composition Phase Ingredients % Method Of Manufacturing A Demineralised Water (DM 85.7 Weigh DM water in MV. Water) B Polyquaternium-37 0.3 add to MV and mix till get clear gel. C Ethylene Glycol Dimaleate 5 Premix C to get clear solution C Propylene Glycol 5 and then add to MV. D PEG-12 Dimethicone 3 Add to MV and mix uniformly E Phenoxyethanol, 0.8 add preservative and fragrance to Ethylhexylglycerin MV nad mix E Fragrance 0.2 F pH adjuster Q.S add to adjust the pH Total 100 Example 3: Table 3: Composition for crosslinking the broken disulfide bonds Shampoo Composition S.N Method Of Phase Ingredients % o Manufacturing Demineralised Water 1 A 49.2 Weigh water in MV and (DM Water) heat it to 45 degrees. Add HYDROXYETHYL 0.20 other phase A ingredients 2 A CELLULOSE slowly to the MV with POLYQUATERNIUM- 0.80 proper stirring. Heat the 3 A 10 MV to 70-75 degree. 4 B Ethyleneglycol Dimaleate 5.00 Premix phase B and heat Propylene Glycol 2.00 the solution till it get solubilised and transfer it to 5 B MV. 6 C COCAMIDE MEA 1.50 7 C GLYCOL STEARATE 2.00 Add phase C ingredients COCAMIDOPROPYL 6.00 one by one to the MV with 8 C BETAINE proper stirring. Ensure 9 C Sodium laureth sulfate 32.00 complete mixing. PERFUM 0.60 10 D (FRAGRANCE) At 40 degrees add perfume 11 D Preservative 0.80 and preservative 12 E pH adjuster q.s. Total 100.1

Claims

We claim, 1. A hair strengthening composition comprising a. an active agent, and b. cosmetically acceptable excipients.

2. The hair strengthening composition as claimed in claim 1 wherein the active agent is of general Formula 1; FG- R-FG' (I) wherein FG and FG' are reactive moieties on either end, capable of reacting to form covalent bonds with at least two thiols and R is a spacer group.

3. The hair strengthening composition as claimed in claim 1, wherein the composition is formulated as a rinse-off composition.

4. The hair strengthening composition as claimed in claim 3, wherein the rinse- off formulation comprises of: a. an active agent; b. a thickening agent; and c. a surfactant, or an emulsifier.

5. The hair strengthening composition as claimed in claim 4, wherein the active agent concentration is preferably 0.1 wt.% to 30 wt.%, more preferably 1 wt.% to 20 wt.%, and most preferably 0.2 wt.% to 10 wt.%.

6. The hair strengthening composition as claimed in claim 4, wherein the thickening agent is selected from, but not limited to synthetic polymers such as polyethylene glycol, acrylic acid based, poloxamer, semi-synthetic polymer such as hydroxyethyl cellulose, natural polymers such as xanthan gum,carrageenan, PEG-150 distearate, and salt such as sodium chloride and combination thereof.

7. The hair strengthening composition as claimed in claim 4, wherein the thickening agent concentration is preferably 0.1 wt.% to 10wt.%, more preferably 0.2 wt.% to 8wt.%, and most preferably 0.2 wt.% to 5wt.% 8. The hair strengthening composition as claimed in claim 4 can additionally contain a conditioning agent.

9. The hair strengthening composition as claimed in claim 8, wherein the conditioning agent is selected from, but not limited to, dimethicone, dimethiconol, amodimethicone, bis-aminopropyl dimethicone, Dipropylene glycol, polysilicone-29, hydrolysed wheat protein, behentrimonium chloride, stearamidopropyl dimethylamine, and combinations thereof.

10. The hair strengthening composition as claimed in claim 8, wherein the conditioning agent is preferably 0.1 wt.% to 15 wt.%, more preferably 0.5 wt.% to 10 wt.%, most preferably 1 wt.% to 5wt.%.

11. The hair strengthening composition as claimed in claim 4 can additionally contain an emollient.

12. The hair strengthening composition as claimed in claim 11, wherein the emollient is selected from, but not limited to polyols such as glycerin, propylene glycol hexylene glycol, caprylyl glycol, triglyceride such as caprylic / capric triglyceride, fatty acid ester such as cetyl palmitate. More than one emollient may be included in the formulation.

13. The hair strengthening composition as claimed in claim 11, wherein the emollient is preferably 0.5 wt.% to 20 wt.%, more preferably 1 wt.% to 15 wt.%, most preferably 2wt.% to 10wt.%.

14. The hair strengthening composition as claimed in claim 4 is in a shampoo format, wherein the surfactant is selected from, but not limited to sodium lauryl sulfate, alkyl aryl sulfonates, isethionate, benzalkonium chloride, polyoxyethylene alkyl ethers, alkyl polyglucoside, polysorbates, polyoxyethylene monolaurate, cocoamidopropyl Betaine, lauryl betaine, or combinations thereof.

15. The hair strengthening composition as claimed in claim 4, wherein the active surfactant content is preferably 0.1 wt.% to 40wt.%, more preferably 2wt.% to 30 wt.%, most preferably 5wt.% to 25 wt.%.

16. The hair strengthening composition as claimed in claim 4 is in a rinse off conditioner format, wherein the emulsifier is selected from, but not limited to cetearyl alcohol, ceteareth-20, glycol stearate, polysorbate-60, polysorbate-80, or combinations thereof.

17. The hair strengthening composition as claimed in claim 4, wherein the emulsifier is preferably 0.1 wt.% to 30wt.%, more preferably 1wt.% to 25wt.%, most preferably 2 wt.% to 15wt.%.

18. The hair strengthening composition as claimed in claim 4, wherein the rinse- off composition optionally further comprises pH adjusting agent, preservatives, chelating agent and fragrance.

19. The pH of composition in claim 4 is in the range of 3 to 10.

20. The hair strengthening composition as claimed in claim 4, wherein the treatment time for rinse-off composition is preferably 1-10 minutes, more preferably 2-8 minutes, most preferably 3-5 minutes.

21. The process for strengthening of hair, by using rinse-off composition as claimed in claim 4, wherein the process comprises following steps; a. applying the composition containing the active agent of Structure 1, on wet hair; FG- R-FG' (I) b. leaving the product of step (a) for approx.5 minutes, and c. rinsing the hair.

22. The hair strengthening composition as claimed in claim 1, wherein the composition is formulated as a leave-in composition.

23. The hair strengthening composition as claimed in claim 22, wherein the leave-in formulation comprises of: a. an active agent; b. a thickening agent; c. an emulsifier.

24. The hair strengthening composition as claimed in claim 23, wherein the active agent concentration is preferably 0.1 wt.% to 30 wt.%, more preferably 1 wt.% to 20 wt.%, and most preferably 0.2 wt.% to 10 wt.%.

25. The hair strengthening composition as claimed in claim 23, wherein the thickening agent is selected from, but not limited to Cellulose, Glycol Stearate and Isohexadecane synthetic polymers such as polyethylene glycol, acrylic acid based, poloxamer, semi-synthetic polymer such as hydroxyethylcellulose, natural polymers such as xanthan gum, carrageenan, PEG-150 distearate, and salt such as sodium chloride and combination thereof.

26. The hair strengthening composition as claimed in claim 23, wherein the thickening agent. concentration is preferably 0.1 wt.% to 10wt.%, more preferably 0.2 wt.% to 8wt.%, and most preferably 0.2 wt.% to 5wt.%.

27. The hair strengthening composition as claimed in claim 23 can additionally contain a conditioning agent.

28. The hair strengthening composition as claimed in claim 27, wherein the conditioning agent is selected from, but not limited to dimethicone, dimethiconol, amodimethicone, bis-aminopropyl dimethicone, Dipropylene glycol, polysilicone-29, hydrolysed wheat protein, behentrimonium chloride, stearamidopropyl dimethylamine, and combinations thereof.

29. The hair strengthening composition as claimed in claim 27, wherein the conditioning agent is preferably 0.1 wt.% to 15 wt.%, more preferably 0.5 wt.% to 10 wt.%, most preferably 1 wt.% to 5wt.%.

30. The hair strengthening composition as claimed in claim 23 can additionally contain an emollient.

31. The hair strengthening composition as claimed in claim 30, wherein the emollient is selected from, but are not limited to polyols such as glycerin, propylene glycol hexylene glycol, caprylyl glycol, triglyceride such as caprylic / capric triglyceride, fatty acid ester such as cetyl palmitate or combinations thereof.

32. The hair strengthening composition as claimed in claim 30, wherein the emollient concentration is preferably 0.5 wt.% to 20 wt.%, more preferably 1 wt.% to 15 wt.%, most preferably 2wt.% to 10wt.%.

33. The hair strengthening composition as claimed in claim 23, wherein the emulsifier is selected from but not limited to cetearyl alcohol, ceteareth-20, glycol stearate, polysorbate-60, polysorbate-80, or combinations thereof. More than one emulsifier may be included.

34. The hair strengthening composition as claimed in claim 23, wherein the emulsifier is preferably 0.1 wt.% to 30wt.%, more preferably 1wt.% to 25wt.%, most preferably 2 wt.% to 15wt.%.

35. The hair strengthening composition as claimed in claim 23, wherein the leave- in composition optionally further comprises pH adjusting agent, preservatives, chelating agent and fragrance.

36. The pH of composition in claim 23 is in the range of 3 to 8.

37. The hair strengthening composition as claimed in claim 22, wherein the leave- in composition is an aqueous serum composition comprises an active agent, a silicone, a thickener, a preservative, chelating agent and a fragrance.

38. A process for hair strengthening composition by using leave–in composition as claimed in claim 23 and 37, wherein the process comprises following steps a. applying the composition with the active agent on wet / dry hair; and b. leaving the product of step (a) as such.

Images