Method for determining an efficacy statement in a decontamination process and corresponding controlled environment

Abstract

A method for determining an efficacy statement in a decontamination process (1) is proposed, wherein in the decontamination process (1) a decontamination agent (2) acts on at least one object (4) in a controlled environment (3), wherein a concentration measurement variable (7) correlating with a concentration of the decontamination agent (2) in the controlled environment (3), a humidity measurement variable (8) correlating with a moisture content in the controlled environment, a temperature measurement variable (9) correlating with a temperature in the controlled environment, and a saturation measurement variable correlating with a saturation are acquired so that that the efficacy statement is determined, preferably in an automated manner, using the acquired measurement variables (7, 8, 9).

Description

[0001] PC 25 2077 C 12 . November 2025

[0002] Methods for determining an efficacy statement in a decontamination process and corresponding controlled environment

[0003] The invention relates to a method for determining an efficacy statement in a decontamination process, wherein in the decontamination process a decontamination agent is introduced into a controlled environment to act on at least one object.

[0004] The invention further relates to a method for evaluating a decontamination process that is carried out in a controlled environment.

[0005] Controlled environments are well-known in the field of pharmaceutical technology and can be characterized, for example, by the fact that state parameters, such as pressure, temperature, air composition, airflow velocity, and / or humidity, and / or substance exchange between the environment and its external environment can be defined in a controlled manner. Examples of controlled environments include containments, particularly isolators and gloveboxes, and restricted access barrier systems (RABS), especially of open or closed type, or biosafety cabinets (BSCs) or laminar flow benches. Controlled environments are used, for example, to reduce or eliminate unwanted interaction with the outside world during a process, preferably an industrial one, such as aseptic manufacturing.One example of an application is the filling or repackaging of a drug, another is the sterile assembly of an applicator for a drug.

[0006] To prepare the controlled environment, a PC 25 2077 C 2 / 23 12 November 2025 is often used.

[0007] A decontamination process is carried out to biologically deactivate viable contaminants. For this purpose, a decontamination agent is applied to the controlled environment. Examples of decontamination agents include life-threatening substances such as hydrogen peroxide, or life-threatening and / or ionizing radiation such as UV and / or gamma radiation and / or high-energy particle radiation.

[0008] The invention is based on the objective of improving the decontamination process in controlled environments.

[0009] To solve the aforementioned problem, the features of claim 1 are provided according to the invention. In particular, it is thus proposed according to the invention to solve the aforementioned problem by recording a concentration measurement that correlates with a concentration of the decontamination agent in the controlled environment and by determining an efficacy statement using the recorded measurement.

[0010] Alternatively or additionally, it may be provided that a moisture measurement correlated with a moisture content in the controlled environment is recorded and an effectiveness statement is determined using the recorded measurement.

[0011] Alternatively or additionally, it can be provided that a temperature measurement correlated with a temperature in the controlled environment is recorded and that the effectiveness statement is determined using the recorded measurement. Advantageously, the effectiveness statement can be determined using the recorded measurements.

[0012] Alternatively or additionally, it may be provided that a saturation measurement correlated with saturation (PC 25 2077 C 3 / 23, November 12, 2025) is recorded and the effectiveness statement is determined from the recorded measurement. Advantageously, the effectiveness statement can be determined using the recorded measurements. A saturation measurement could, for example, be the saturation itself, or the dew point and / or the dew point temperature.

[0013] The measured quantity can be a measured and / or a calculated quantity.

[0014] This can, for example, improve the decontamination process, as the concentration of the decontamination agent, such as hydrogen peroxide (H₂O₂), can be measured for the first time to control the decontamination process. Thus, the supply of the decontamination agent can be controlled based on its concentration in the controlled environment. Preferably, the effectiveness can be determined automatically. This eliminates the need for human intervention, allowing for faster and more cost-effective work. Unnecessarily long decontamination processes can be avoided. A concentration measurement could be, for example, a parts-per-million (ppm) measured quantity of the concentrating agent. A humidity measurement could be, for example, absolute humidity, relative humidity, saturation humidity, and / or dew point.A temperature measurement can be, for example, a temperature measured in degrees Celsius or Kelvin.

[0015] In general, an efficacy statement can be characterized, for example, by the fact that it allows a statement about the degree to which decontamination is carried out. An example of an efficacy statement is the kill factor, i.e., the statement by what factor or by what order of magnitude biologically viable material is reduced by decontamination. Determining, and in particular calculating, an efficacy statement has the advantage that the process under consideration becomes comparable to known processes and, in particular, monitorable, i.e., whether it is monitored using established verification methods, such as those employing chemical or biological indicators. The invention has the advantage here that a monitoring result is available immediately and, in particular, without lengthy incubation or other biological propagation.

[0016] Effectiveness can be understood as the extent to which a measure, such as decontamination, a substance, or an action, achieves the desired effect and reaches the intended goals.

[0017] The efficacy statement can thus help a user to quantify how successful the decontamination was in the controlled environment.

[0018] Efficacy statements can be calculated, for example, from an exposure time, a saturation (or a correlating parameter such as a dew point) of H2O2 (or, more generally, a decontamination agent), and / or a concentration of H2O2 (or, more generally, the decontamination agent), or determined (analytically and / or empirically) using computer-aided methods. Instead of saturation, a dew point temperature, for example, can also be used.

[0019] In an advantageous design, it may be possible to additionally process the duration of exposure to the decontamination agent to determine the effectiveness. This can, for example, establish a minimum time period for decontamination. Furthermore, time recording can be used to log the previously described parameters (PC 25 2077 C 5 / 23, November 12, 2025).

[0020] In an advantageous design, it can be provided that a flow velocity in the controlled environment is additionally processed to determine the effectiveness statement. This allows for a particularly accurate and / or meaningful effectiveness statement to be generated.

[0021] In an advantageous embodiment, hydrogen peroxide can be used as the decontamination agent. Hydrogen peroxide can biologically deactivate viable contaminants and thus prevent their growth. Preferably, hydrogen peroxide absorbed in a gas phase can be used. This can, for example, eliminate the need to pre-evaporate the hydrogen peroxide. As a gas phase, the hydrogen peroxide can wet all surfaces to be decontaminated in the controlled environment.

[0022] In an advantageous design, it may be provided that at least two measured variables are recorded at a common measurement point in the controlled environment. This allows, for example, a correlation between the measured variables to be established, which permits conclusions to be drawn about the effectiveness of the decontamination process. In particular, it may be provided that the three measured variables are recorded at a common measurement point in the controlled environment. This allows, for example, a correlation between the three measured variables to be established, which permits conclusions to be drawn about the effectiveness of the decontamination process.

[0023] In an advantageous design, it may be provided that an efficacy indicator is calculated that correlates with the proportion of microorganisms surviving the contamination (PC 25 2077 C 6 / 23 12 November 2025). This allows, for example, a user to quickly and easily understand the effectiveness of the decontamination.

[0024] In an advantageous design, it can be provided that the determination of the efficacy statement is trained and / or validated in a calibration mode using at least one set bioindicator and / or at least one chemical indicator. This allows for good comparability with existing validation methods.

[0025] In an advantageous design, it may be possible to determine a relative saturation and / or a dew point for the decontamination agent. This allows for particularly well-defined conditions for effective decontamination.

[0026] For example, the determination can be achieved by specifying values ​​for a controller and / or measuring values. By specifying values ​​for the controller, process-optimized values ​​can be achieved. Through measurement, a control loop can be established to control stored setpoint values.

[0027] In particular, it may be provided that a relative saturation of at least 80% or at least 95%, and especially at least 100%, is achieved in the controlled environment. Experiments have shown that at such high saturations, the differences in measurement and / or response behavior between different bioindicators disappear or are at least negligible. A saturation greater than 100% may refer to supersaturation, where, in addition to the 100% saturated vapor, PC 25 2077 C 7 / 23 12 November 2025

[0028] Droplets of disinfectant are introduced into the environment.

[0029] Alternatively or additionally, to solve the aforementioned problem, the features of the dependent claim, which relates to a method for evaluating the decontamination process, are provided according to the invention.In particular, it is therefore proposed that in a setup mode at least one reference point and a network of several measuring points are defined in the controlled environment, wherein during a first execution of the decontamination process measured values ​​are recorded at the at least one reference point and at the measuring points, and wherein a functional relationship between the measured values ​​of the at least one reference point and the measured values ​​of the measuring points is determined, and that in an operating mode at least one measured value of the at least one reference point is recorded, and that in the operating mode at least one piece of information relating to at least one measuring point of the network is automatically determined from the at least one recorded measured value with the functional relationship.This makes it possible, for example, to evaluate the decontamination process by drawing conclusions about the entire controlled environment from at least one reference point. This eliminates the need for multiple measurement points in this operating mode, which can save costs. Measurements at critical but difficult-to-access locations can also be easily replaced by measurements at easily accessible locations.

[0030] In an advantageous embodiment, it may be provided that at least one concentration measurement correlated with a concentration of the decontamination agent in the controlled environment, or a humidity measurement correlated with a moisture content in the controlled environment, is recorded at each reference point. This allows, for example, the concentration of the decontamination agent to be related to the moisture content at each reference point. Alternatively or additionally, it may be provided that a temperature measurement correlated with a temperature in the controlled environment is recorded. This allows, for example, the concentration of the decontamination agent and / or the humidity to be related to the temperature at each reference point. Alternatively or additionally, it may be provided that the aforementioned measurements are recorded at each measuring point.This makes it possible, for example, to correlate the concentration of the decontamination agent and / or the humidity with the temperature at each measuring point. Other environmental parameters, such as air velocity and air pressure, can also be recorded.

[0031] In an advantageous embodiment, at least one measuring sensor can be arranged at each reference point during setup mode. This can, for example, enable the measuring sensor at each reference point to record a measured quantity. Alternatively or additionally, at least one measuring sensor can be arranged at each measuring point. This can, for example, enable the measuring sensor at each measuring point to record a measured quantity. In particular, it can be provided that the measuring sensors of the network of measuring points are removed from the controlled environment before the operating mode. This can, for example, enable calibration of the reference points using the measuring points during setup mode, so that the measuring points are not needed in a later operating mode to provide an accurate indication of the concentration of the decontamination agent.The one in PC 25 2077 C 9 / 23 12 . November 2025.

[0032] In setup mode, the measured values ​​at the reference point can be evaluated together with the measured values ​​at the measuring points to enable an assessment of the decontamination process in setup mode. In operating mode, the measuring points can then be omitted, allowing for an assessment of the decontamination process using only the measured values ​​at the reference points.

[0033] In an advantageous design, the measuring sensors at the measuring points can be battery-powered. This allows, for example, the measuring points to operate autonomously without an external power supply, thus enabling them to be positioned flexibly within the controlled environment. Alternatively or additionally, the measuring sensors can be designed for wireless transmission of the measured values. This allows, for example, the wireless transmission of recorded data. This also has the advantage of eliminating the need for additional cable decontamination.

[0034] In an advantageous design, it can be provided that, for the determination of the functional relationship, at least one measuring point is automatically determined where the effectiveness of the applied decontamination agent is lower than at at least one reference point. This can, for example, improve the calibration of the reference points for the operating mode. Points where decontamination occurs particularly slowly, for example because they are difficult to access, can thus be easily replaced by comparative measurements at more easily accessible points.

[0035] In an advantageous design, it may be provided, PC 25 2077 C 10 / 23 12 November 2025, that the measured values ​​correlate with a statement of effectiveness in one or the decontamination process. This allows, for example, conclusions to be drawn about the effectiveness of the decontamination process from the measured values.

[0036] In an advantageous design, it can be provided that more than one physical measurement quantity is recorded at each measuring point. This can, for example, make it possible to use several measurements to evaluate the decontamination process and thus improve the evaluation.

[0037] In an advantageous design, each measuring point can be uniquely assigned a physical quantity. This allows, for example, a single physical quantity to be measured at a single measuring point. Alternatively or additionally, the network can be divided into different types of measuring points. This allows, for example, the network to measure different physical quantities at different measuring points. It can also allow all physical quantities to be measured at each measuring point.

[0038] The aim of the decontamination process can be to introduce enough hydrogen peroxide to achieve a saturation level slightly above 100%. This can also be described as supersaturation. However, tests have shown that a saturation level above 150% does not significantly improve the system. A saturation level slightly above 100%, but well below 150%, is preferable.

[0039] This can be achieved by first introducing hydrogen peroxide and determining the saturation level. Even if 100% saturation is reached in the system, the supply of hydrogen peroxide can continue. PC 25 2077 C 11 / 23 12 November 2025

[0040] This supply can be achieved by introducing hydrogen peroxide droplets, which, for example, have sizes in the submicron or micro range, in particular < 10 pm, for example approximately 5 pm, mean droplet size.

[0041] These droplets can be introduced with dry air, where "dry" means, for example, that the moisture content of the introduced air is below the humidity level that is achieved or targeted in the indoor air to prepare the insulator. Typically, in practice, the humidity will be very low, around a dew point of -20°C, i.e., 1% relative humidity. However, higher values ​​are also conceivable.

[0042] In the decontamination process, these droplets can be introduced relatively quickly and / or turbulently through nozzles. Generally speaking, these velocities are significantly higher than the velocity of the unidirectional flow, which is established as the preferred direction of airflow during normal operation.

[0043] The applied velocity, which causes turbulence and suspension of the droplets, is approximately ten times higher than the usual flow velocity during normal operation. Even higher velocities are conceivable.

[0044] The droplets can act as a suspended reservoir for the decontamination agent, since the decontamination agent has the disadvantage of degrading, decomposing, or depositing itself on surfaces quickly, not only when removing reproductive material but also generally without further action. Therefore, the invention achieves improved robustness through the provision and aerosolization of the droplets (PC 25 2077 C 12 / 23, November 12, 2025).

[0045] The invention will now be described in more detail with reference to exemplary embodiments, but is not limited to these. Further exemplary embodiments result from combining the features of one or more claims with each other and / or with one or more features of the exemplary embodiments.

[0046] They show

[0047] Fig. 1 shows a controlled environment in which a decontamination agent acts on objects.

[0048] Fig. 2 shows a controlled environment with a network of measuring points and reference points.

[0049] Fig. 3 shows a representation of vapor molecules,

[0050] Fig. 4 shows a representation of a supersaturated system with

[0051] vapor molecules and droplets and

[0052] Fig. 5 shows a diagram with different states of a system.

[0053] Fig. 1 shows a method for determining a

[0054] Efficacy statement in a decontamination process 1. In decontamination process 1, a decontamination agent 2 is introduced into a controlled environment 3 to act on objects 4. However, decontamination process 1 not only acts on objects in the controlled environment 3, but also on the air present in the interior 5, as well as the interior walls 6 of the controlled environment 3. During the process, a concentration measurement 7, which correlates with the concentration of the decontamination agent 2 in the controlled environment 3, is recorded. A humidity measurement 8, which correlates with the moisture content in the controlled environment 3, and a temperature measurement 9, which correlates with the temperature in the controlled environment 3, are also recorded. The effectiveness statement is automatically determined using the recorded measurements 7, 8, 9.In further exemplary embodiments, the measured quantity can also be a saturation measurement quantity that correlates with saturation, in particular a dew point or a dew point temperature.

[0055] The measured quantity does not have to be measured directly; it can also be provided that the measured quantity is calculated from measured values.

[0056] To determine the efficacy statement, the duration of exposure to the decontamination agent 2 is also processed. Thus, the exposure time of the decontamination agent 2 can be related to the measured variables 7, 8, and 9.

[0057] Gaseous hydrogen peroxide 10 is used as the decontamination agent 2.

[0058] The three measured variables 7, 8, 9 are recorded in the controlled environment 3 at a common measuring point 18.

[0059] A key figure is calculated as an indicator of effectiveness based on the proportion of microorganisms that survive the decontamination process 1; this figure correlates with the proportion.

[0060] The functional relationship can be described in a device-specific manner.

[0061] Calibration mode by comparison with the (according to PC 25 2077 C 14 / 23 12 November 2025)

[0062] The system can be trained on values ​​of a bioindicator and / or a (bio)chemical / enzymatic indicator obtained during incubation. For example, this can be done with a neural network using measurement data.

[0063] During operation and / or calibration mode, a relative saturation and / or dew point for the decontamination agent is determined. For this purpose, values ​​are measured and compared with target values ​​to specify desired values ​​close to, at, or above 100% saturation. Fig. 3 schematically shows hydrogen peroxide vapor molecules 21. Fig. 4 schematically shows a supersaturated vapor 23 as defined in the application. Here, hydrogen peroxide vapor 21 is present. This gas has a saturation of 100%. Additionally, droplets of liquid hydrogen peroxide 22 are present. The system is thus supersaturated, since the gas phase contains more hydrogen peroxide molecules than would be possible at 100% saturation.

[0064] Figure 5 shows, in a graph where relative saturation is plotted on the x-axis and hydrogen peroxide concentration on the y-axis, an interaction of hydrogen peroxide vapor molecules 21, water molecules, and hydrogen peroxide droplets 22. The maximum decontamination effect is achieved at maximum hydrogen peroxide concentration and 100% relative saturation. This maximum decontamination effect is stabilized or even improved when hydrogen peroxide droplets 22 are added to the system.

[0065] Fig. 2 shows a method for evaluating a decontamination process 2 carried out in a controlled environment 3. In a (network-specific) setup mode 11, a reference point 12 and a network of measurement points 13 are defined. During a first PC 25 2077 C 15 / 23 12 November 2025

[0066] During decontamination process 2, measurements 16 and 17 are recorded at reference point 12 and at measuring points 13. A functional relationship is determined between the measurements 16 at reference point 12 and the measurements 17 at measuring points 13.

[0067] In an operating mode 14, which is shown by way of example in Fig. 1, measured values ​​16 are recorded at the reference point 12, wherein in the operating mode 14 information relating to a measuring point 13 is also automatically determined from the measured values ​​16 with the functional relationship.

[0068] At each reference point 12 and measuring point 13, a concentration measurement 7, correlating with the concentration of the decontamination agent 2 in the controlled environment 3, as well as a humidity measurement 8, correlating with the moisture content in the controlled environment 3, and a temperature measurement 9, correlating with the temperature in the controlled environment 3, are recorded. In a further embodiment, air velocity and air pressure are also recorded.

[0069] In setup mode 11, a measuring sensor 15 is positioned at each reference point 12 and measuring point 13. Before switching to operating mode 14, the measuring sensors 15 of the network of measuring points 13 are removed from the controlled environment 3.

[0070] In another embodiment, the measuring sensors 15 at the measuring points 13 are battery-operated and designed for wireless transmission of the measured values ​​17.

[0071] Fig. 2 shows how the measuring points 13 are connected with cables 20. The cables 20 shown in Fig. 1 lead from the measuring sensors 15 out of the controlled environment 3 to be evaluated outside, for example on a PC / laptop / tablet (not shown in Fig. 25 2077 C 16 / 23 12 November 2025).

[0072] To determine the functional relationship, a measuring point 13 is automatically determined at which the effectiveness of the introduced decontamination agent 2 is lower than at the reference point 12.

[0073] The measured values ​​16 , 17 each correlate with an efficacy statement in the decontamination process 1 .

[0074] At each measuring point 13, more than one physical measurement quantity 7 , 8 , 9 is recorded.

[0075] Each measuring point 13 is uniquely assigned a physical measured quantity 7, 8, 9. In a further embodiment, the network is divided into different types of measuring points 13.

[0076] The dispensing point 19, shown schematically in Figs. 1 and 2, serves to distribute and dispense the decontamination agent 2 into the controlled environment 3. This can, for example, be a nozzle.

[0077] A method for determining an efficacy statement in a decontamination process 1 is proposed, wherein in the decontamination process 1 a decontamination agent 2 acts on at least one object 4 in a controlled environment 3, wherein a concentration measurement 7 correlated with a concentration of the decontamination agent 2 in the controlled environment 3, a humidity measurement 8 correlated with a moisture content in the controlled environment and a temperature measurement 9 correlated with a temperature in the controlled environment are recorded, such that the efficacy statement, PC 25 2077 C 17 / 23 12 November 2025, is preferably determined automatically using the recorded measurements 7, 8, 9.

[0078] PC 25 2077 C 18 / 23 12 . November 2025

[0079] Reference symbol list

[0080] 1 Decontamination process

[0081] 2 decontamination agents

[0082] 3 controlled environment

[0083] 4 Objects

[0084] 5 Interior

[0085] 6 Interior wall

[0086] 7 Concentration measurement

[0087] 8 Humidity measurement large

[0088] 9 Temperature measurement

[0089] 10 Hydrogen peroxide

[0090] 11 Setup mode

[0091] 12 Reference point

[0092] 13 measuring point

[0093] 14 Operating mode

[0094] 15 measuring sensor

[0095] 16 Measurement of the reference point

[0096] 17 Measured value of the measuring point

[0097] 18 Measurement location

[0098] 19 Delivery point

[0099] 20 cables

[0100] 21 Water to f peroxide id- Steam

[0101] 22 Water to f fperox id- Drops chen

[0102] 23 Supersaturated steam

Claims

PC 25 2077 C 19 / 23 November 12, 2025 Claims 1. Method for determining an efficacy statement in a decontamination process (1) , wherein in the decontamination process (1) a decontamination agent (2) is introduced into a controlled environment (3) to act on at least one object (4), characterized in that a concentration measurement (7) correlating with a concentration of the decontamination agent (2) in the controlled environment (3), and / or a humidity measurement (8) correlating with a moisture content in the controlled environment, and / or a temperature measurement (9) correlating with a temperature in the controlled environment (3), and / or a saturation measurement (9) correlating with a saturation are recorded, and that the efficacy statement is determined, preferably automatically, using the recorded measurements (7, 8, 9).

2. Method according to claim 1, characterized in that, for the determination of the effectiveness statement, a duration of exposure of the decontamination agent (2) in the controlled environment (3) is additionally processed, in particular wherein the flow velocity is taken into account.

3. Method according to one of the preceding claims, characterized in that hydrogen peroxide (10) is used as a decontamination agent (2), preferably in a gas phase.

4. Method according to one of the preceding claims, characterized in that at least two, in particular the three measured quantities (7, 8, 9) are recorded at a common measuring point (18) in the controlled environment (3).

5. Method according to any of the preceding claims, wherein PC 25 2077 C 20 / 23 12 November 2025 indicates that the efficacy statement is calculated as a key figure that correlates with a proportion of the microorganisms that survive the decontamination process (1).

6. Method according to one of the preceding claims, characterized in that the determination of the efficacy statement is trained and / or validated in a calibration mode using at least one bioindicator and / or at least one (bio) chemical / enzymatic indicator.

7. Method according to one of the preceding claims, characterized in that a relative saturation and / or a dew point for the decontamination agent is determined, in particular specified and / or measured, in particular wherein a relative saturation of at least 80% or at least 95%, in particular at least 100%, is achieved in the controlled environment.

8. Procedure for evaluating a decontamination process (1) , which is carried out in a controlled environment (3), in particular using a method according to one of the preceding claims, characterized in that in a setup mode (11) at least one reference point (12) and a network of several measuring points (13) are defined in the controlled environment (3), wherein during a first execution of the decontamination process (1) measured values ​​(16, 17) are recorded at the at least one reference point (12) and at the measuring points (13) and wherein a functional relationship between the measured values ​​(16) of the at least one reference point (12) and the measured values ​​(17) of the measuring points (13) is determined, and that in an operating mode (14) at least one measured value (16) of the at least one reference point (12) is recorded and PC 25 2077 C 21 / 23 12 November 2025 that in the operating mode (14) at least one recorded measurement value (16) with the functional relationship at least one piece of information relating to at least one measuring point (13) of the network is automatically determined.

9. Method according to the preceding claim, characterized in that at each reference point (12) and / or measuring point (13) at least one concentration measurement (7) correlated with a concentration of the decontamination agent (2) in the controlled environment (3), one humidity measurement (8) correlated with a moisture content in the controlled environment (3) and / or one temperature measurement (9) correlated with a temperature in the controlled environment (3) is / are detected.

10. Method according to one of claims 8 or 9, characterized in that in the setup mode (11) at least one measuring sensor (15) is arranged at each reference point (12) and / or measuring point (13), in particular wherein the measuring sensors (15) of the network of measuring points (13) are removed from the controlled environment (4) before the operating mode (14).

11. Method according to one of claims 8 to 10, characterized in that the measuring sensors (15) at the measuring points (13) are battery-operated and / or designed for wireless transmission of the measured values ​​(17).

12. Method according to one of claims 8 to 11, characterized in that for the determination of the functional relationship at least one measuring point (13) at which the effectiveness of the introduced decontamination agent (2) is lower than at the at least one reference point (12) is automatically determined.

13. Method according to any one of claims 8 to 12, wherein PC 25 2077 C 22 / 23 12 November 2025 indicated that the measured values ​​(16, 17) each correlate with an efficacy statement in one or the decontamination process (1).

14. Method according to one of claims 8 to 13, characterized in that more than one physical measurement quantity (7, 8, 9) is detected at each measuring point (13).

15. Method according to one of claims 8 to 14, characterized in that each measuring point (13) is uniquely assigned a physical measured quantity (7, 8, 9) and / or that the network is divided into different types of measuring points (13) is subdivided.

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